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[PMID]:29390258
[Au] Autor:Di HX; Liu FY; Yang SD; Wang H; Yang DL; Ding WY
[Ad] Endereço:Department of Spinal Surgery, The Third Hospital of Hebei Medical University.
[Ti] Título:Short-segment fixation with a cement-augmented pedicle screw for Kummell disease: Case report.
[So] Source:Medicine (Baltimore);96(50):e8617, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Kummell disease is described as avascular necrosis of a vertebral body that occurred in a delayed fashion after a minor trauma. Anterior, posterior, and anterior-posterior approaches have been reported. Nevertheless, there is no standard treatment for patients with Kummell disease. PATIENT CONCERNS: We reported a successful cement-augmented pedicle screw placement in a patient with Kummell disease. A 63-year-old woman with serious osteoporosis complained persistent back pain with progressive lower extremities weakness for almost 2 years. DIAGNOSES: The diagnosis of Kummell disease was mainly depended on clinical symptoms and imaging examinations. INTERVENTIONS: The application of a cement-augmented pedicle screw was designed to treat this illness. OUTCOMES: The operation was successful without any complications. The patient stated that symptoms were obviously improved in 1 week after operation. LESSONS: The application of a cement-augmented pedicle screw is an effective treatment option for Kummell disease.
[Mh] Termos MeSH primário: Cimentos para Ossos
Fixação Interna de Fraturas/instrumentação
Osteonecrose/cirurgia
Parafusos Pediculares
[Mh] Termos MeSH secundário: Dor nas Costas/etiologia
Dor nas Costas/cirurgia
Feminino
Fixação Interna de Fraturas/métodos
Fraturas por Compressão/complicações
Fraturas por Compressão/diagnóstico por imagem
Fraturas por Compressão/cirurgia
Seres Humanos
Vértebras Lombares/diagnóstico por imagem
Vértebras Lombares/lesões
Vértebras Lombares/patologia
Vértebras Lombares/cirurgia
Meia-Idade
Osteonecrose/diagnóstico por imagem
Osteonecrose/etiologia
Fraturas por Osteoporose/complicações
Fraturas por Osteoporose/diagnóstico por imagem
Fraturas por Osteoporose/cirurgia
Fraturas da Coluna Vertebral/complicações
Fraturas da Coluna Vertebral/diagnóstico por imagem
Fraturas da Coluna Vertebral/cirurgia
Vértebras Torácicas/diagnóstico por imagem
Vértebras Torácicas/lesões
Vértebras Torácicas/patologia
Vértebras Torácicas/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Cements)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008617


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[PMID]:29252744
[Au] Autor:Zimmerman RM; Allen EA; Higgins JP
[Ad] Endereço:The Curtis National Hand Center, MedStar Union Memorial Hospital, Baltimore, Maryland.
[Ti] Título:Chondrocyte Viability 3.5 Years Following a Vascularized Medial Femoral Trochlea Osteocartilaginous Free Flap.
[So] Source:JBJS Case Connect;6(4):e90, 2016 Oct-Dec.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: A 30-year-old woman underwent arthroscopy for wrist pain 3.5 years following a medial femoral trochlea (MFT) osteocartilaginous free flap for Kienböck disease, which provided the opportunity to examine the transferred cartilage in vivo. Arthroscopy revealed no evidence of chondrolysis, and histologic examination revealed uniformly viable chondrocytes within a matrix consistent with fibrocartilage. CONCLUSION: To the best of our knowledge, the long-term viability of chondrocytes following an MFT free flap has not been previously documented. This case provides early evidence that free tissue transfer based on the descending genicular artery can provide a durable solution for osteocartilaginous defects.
[Mh] Termos MeSH primário: Cartilagem/fisiologia
Condrócitos/fisiologia
Osso Semilunar/transplante
Osteonecrose/cirurgia
[Mh] Termos MeSH secundário: Adulto
Artroscopia
Transplante Ósseo
Sobrevivência Celular
Feminino
Retalhos de Tecido Biológico
Seres Humanos
Articulação do Punho/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00023


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[PMID]:29315006
[Au] Autor:Pountos I; Giannoudis PV
[Ad] Endereço:a Academic Department of Trauma & Orthopaedics, School of Medicine , University of Leeds , Leeds , United Kingdom.
[Ti] Título:The role of Iloprost on bone edema and osteonecrosis: Safety and clinical results.
[So] Source:Expert Opin Drug Saf;17(3):225-233, 2018 Mar.
[Is] ISSN:1744-764X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Iloprost is a commercially available prostaglandin I (PGI ) analogue that is shown to have antithrombotic, vasodilatative and antiproliferative effects. A number of clinical studies have shown that Iloprost can be effective in the management of bone marrow oedema and the treatment of avascular necrosis. The aim of this manuscript is to present our current understanding on the effect of Iloprost on the treatment of these conditions. Areas covered: The authors offer a comprehensive review of the existing literature on the experimental and clinical studies analysing the effect of Iloprost on bone, bone marrow oedema and avascular necrosis. Expert opinion: The available data from the clinical studies suggest that Iloprost has limited effect in advanced stages of avascular necrosis. However, literature suggests that Iloprost administration can be a viable option in the management of bone marrow oedema and early stages of osteonecrosis. Despite these promising results its effect on bone homeostasis needs further elucidation. Moreover, further data on its safety, dosage and efficiency through randomized multicenter studies are desirable in order to reach final conclusions.
[Mh] Termos MeSH primário: Doenças da Medula Óssea/tratamento farmacológico
Edema/tratamento farmacológico
Iloprosta/uso terapêutico
Osteonecrose/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Doenças da Medula Óssea/patologia
Edema/patologia
Seres Humanos
Iloprosta/efeitos adversos
Osteonecrose/patologia
Vasodilatadores/efeitos adversos
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Vasodilator Agents); JED5K35YGL (Iloprost)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1080/14740338.2018.1424828


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[PMID]:29390489
[Au] Autor:Li HK; Hao DJ; Yang JS; Huang DG; Yu CC; Zhang JN; Gao L; Li H; Qian B
[Ad] Endereço:Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
[Ti] Título:Percutaneous kyphoplasty versus posterior spinal fixation with vertebroplasty for treatment of Kümmell disease: A case-control study with minimal 2-year follow-up.
[So] Source:Medicine (Baltimore);96(51):e9287, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This is a retrospective case-control study.The aim of this study was to compare the surgical results of percutaneous kyphoplasty (KP) and posterior spinal fixation with vertebroplasty (PSF+VP) for treatment of Kümmell disease (KD).KD is rare form of post-traumatic delayed avascular necrosis of the vertebral body. It is reported that KP is an effect measure for treatment of KD. Some studies have recommended posterior spinal fixation with vertebroplasty for KD.A total of 100 patients with KD who underwent spinal surgery at our hospital were enrolled from January 2008 to December 2013. The inclusion criteria were monosegment lesion without neurological deficit; the segments are restricted to T11-L2; conservative treatment is invalid. The exclusion criteria were metastatic spinal tumors, infection, primary bone tumor, and multiple myeloma; bisegments and multi-segments; patients with neurological symptoms; the defect of posterior wall of vertebral body; the occupying of vertebral canal. The symptomatic vertebrae were restricted to T11-L2. Patients who were followed-up for less than 2 years after surgery were excluded. Finally, there are 25 patients in the KP group and 21 in the PSF+VP group. There were no significant differences in patient age, disease duration, or the length of follow-up between the 2 groups.Operative time (43.2 ±â€Š21.8 vs 230.6 ±â€Š87.1 minutes) was significantly longer and bleeding volume (5.3 ±â€Š3.1 vs 215.0 ±â€Š170.2 mL) significantly greater in the PSF+VP group. No significant difference between the 2 groups was observed in Visual analog scale score (VAS) (1.3 ±â€Š0.9 vs 1.2 ±â€Š0.9), Oswestry disability index score (ODI) (27.2 ±â€Š9.0 vs 26.0 ±â€Š6.3), and Cobb angle (17.0 ±â€Š7.2 vs 16.5 ±â€Š2.8). KP resulted in a shorter operation time, less bleeding volume, and fewer postoperative complications than PSF+VP.This study shows that both treatments KP and PSF+VP for KD can be safe and effective for the patients with monosegment lesion and without neurological deficit. However, KP show the advantages in a shorter surgical duration, less blood loss, and fewer postoperative complications.
[Mh] Termos MeSH primário: Cifoplastia/métodos
Osteonecrose/diagnóstico por imagem
Osteonecrose/cirurgia
Doenças da Coluna Vertebral/diagnóstico por imagem
Doenças da Coluna Vertebral/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Perda Sanguínea Cirúrgica
Estudos de Casos e Controles
Distribuição de Qui-Quadrado
Bases de Dados Factuais
Feminino
Seguimentos
Seres Humanos
Cifoplastia/efeitos adversos
Masculino
Meia-Idade
Duração da Cirurgia
Osteonecrose/fisiopatologia
Medição da Dor
Complicações Pós-Operatórias/epidemiologia
Complicações Pós-Operatórias/fisiopatologia
Estudos Retrospectivos
Índice de Gravidade de Doença
Doenças da Coluna Vertebral/fisiopatologia
Fatores de Tempo
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Vertebroplastia/efeitos adversos
Vertebroplastia/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009287


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[PMID]:29310416
[Au] Autor:Tomori Y; Sawaizumi T; Mitsuhiko N; Takai S
[Ti] Título:Medium-term outcome of closed radial wedge osteotomy of the distal radius for Preiser disease with concomitant Kienböck disease: Two case reports and a literature review.
[So] Source:Medicine (Baltimore);96(48):e9002, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Idiopathic avascular necrosis of the scaphoid or lunate bone are known as Preiser disease and Kienböck disease, respectively. Although there are reports of avascular necrosis involving more than one carpal bone, concurrent idiopathic avascular necrosis of the scaphoid and lunate bones is rare, with only five cases reported in the English literature (including the two herein). Although the optimum treatment for Preiser disease with concomitant Kienböck disease has not been established, our cases underwent closed radial wedge osteotomy based on the evidence of satisfactory outcomes for treating Kienböck disease. We report the medium-term results of closed radial wedge osteotomy of the distal radius in two cases of Preiser disease with concomitant Kienböck disease. PATIENT CONCERNS: We presented two patients with concomitant Preiser and Kienböck diseases. Although both smoked cigarettes, neither had any other risk factors; there was no history of trauma, although both women had jobs that required relatively heavy or repetitive manual labor. DIAGNOSES: Two patients were diagnosed by radiographs and magnetic resonance imaging of the wrists. INTERVENTIONS: A non-surgical strategy of splint immobilization and analgesia was not effective, and surgery was ultimately required. OUTCOMES: Satisfactory medium-term results were achieved with closed radial wedge osteotomy of the distal radius in both cases. Although there was imaging evidence of progression of dorsal intercalated segmental instability deformity, neither of the patients was symptomatic and both declined salvage surgery. LESSONS: We compare our cases and treatment strategy with others reported in the literature. Our cases suggest that closed radial wedge osteotomy of the distal radius is a safe and relatively straightforward means of treating patients with this rare combination of wrist disorders, and appears to obviate the need for more extensive salvage procedures.
[Mh] Termos MeSH primário: Osteonecrose/cirurgia
Osteotomia
Rádio (Anatomia)/cirurgia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Osteonecrose/diagnóstico por imagem
Osteonecrose/tratamento farmacológico
Rádio (Anatomia)/diagnóstico por imagem
Contenções
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009002


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[PMID]:28801039
[Au] Autor:Alhamdani M; Kelly C
[Ad] Endereço:Department of Emergency Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital, 506 6th Street, Brooklyn, NY 11215, United States. Electronic address: Dr.mazin_alhamdani@hotmail.com.
[Ti] Título:Kohler's disease presenting as acute foot injury.
[So] Source:Am J Emerg Med;35(11):1787.e5-1787.e6, 2017 Nov.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Kohler's disease is rare cause of foot pain and limping in the pediatric population. The exact etiology of Kohler's disease is unknown. It usually presents as sudden and unexplained foot pain and limping. We report a case of a 5-year-old male who presented to the Pediatric Emergency Department with foot pain and inability to bear weight for two days after overactivity and acute foot injury. The patient was eventually diagnosed with Kohler's disease (avascular necrosis of the navicular bone). Although Kohler's disease is not very common, it should be considered in the differential diagnosis of foot pain in the pediatric population, as it may prevent unnecessary tests and treatments.
[Mh] Termos MeSH primário: Osteocondrose/diagnóstico por imagem
Osteonecrose/diagnóstico por imagem
Ossos do Tarso/diagnóstico por imagem
[Mh] Termos MeSH secundário: Pré-Escolar
Diagnóstico Diferencial
Traumatismos do Pé/diagnóstico
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


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[PMID]:28774452
[Au] Autor:Rupasov A; Cain U; Montoya S; Blickman JG
[Ad] Endereço:Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 648, Rochester, NY 14642-0636, USA.
[Ti] Título:Imaging of Posttraumatic Arthritis, Avascular Necrosis, Septic Arthritis, Complex Regional Pain Syndrome, and Cancer Mimicking Arthritis.
[So] Source:Radiol Clin North Am;55(5):1111-1130, 2017 Sep.
[Is] ISSN:1557-8275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This article focuses on the imaging of 5 discrete entities with a common end result of disability: posttraumatic arthritis, a common form of secondary osteoarthritis that results from a prior insult to the joint; avascular necrosis, a disease of impaired osseous blood flow, leading to cellular death and subsequent osseous collapse; septic arthritis, an infectious process leading to destructive changes within the joint; complex regional pain syndrome, a chronic limb-confined painful condition arising after injury; and cases of cancer mimicking arthritis, in which the initial findings seem to represent arthritis, despite a more insidious cause.
[Mh] Termos MeSH primário: Artrite/diagnóstico por imagem
Síndromes da Dor Regional Complexa/diagnóstico por imagem
Diagnóstico por Imagem/métodos
Articulações/lesões
Osteonecrose/diagnóstico por imagem
[Mh] Termos MeSH secundário: Artrite Infecciosa/diagnóstico por imagem
Diagnóstico Diferencial
Seres Humanos
Articulações/diagnóstico por imagem
Neoplasias
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28759822
[Au] Autor:Strojan P; Hutcheson KA; Eisbruch A; Beitler JJ; Langendijk JA; Lee AWM; Corry J; Mendenhall WM; Smee R; Rinaldo A; Ferlito A
[Ad] Endereço:Department of Radiation Oncology, Institute of Oncology, Ljubljana, Slovenia. Electronic address: pstrojan@onko-i.si.
[Ti] Título:Treatment of late sequelae after radiotherapy for head and neck cancer.
[So] Source:Cancer Treat Rev;59:79-92, 2017 Sep.
[Is] ISSN:1532-1967
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Radiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head and neck. Despite enormous advances in RT planning and delivery, a significant number of patients will experience radiation-associated toxicities, especially those treated with concurrent systemic agents. Many effective management options are available for acute RT-associated toxicities, but treatment options are much more limited and of variable benefit among patients who develop late sequelae after RT. The adverse impact of developing late tissue damage in irradiated patients may range from bothersome symptoms that negatively affect their quality of life to severe life-threatening complications. In the region of the head and neck, among the most problematic late effects are impaired function of the salivary glands and swallowing apparatus. Other tissues and structures in the region may be at risk, depending mainly on the location of the irradiated tumor relative to the mandible and hearing apparatus. Here, we review the available evidence on the use of different therapeutic strategies to alleviate common late sequelae of RT in head and neck cancer patients, with a focus on the critical assessment of the treatment options for xerostomia, dysphagia, mandibular osteoradionecrosis, trismus, and hearing loss.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/mortalidade
Neoplasias de Cabeça e Pescoço/radioterapia
Lesões por Radiação/fisiopatologia
Radioterapia/efeitos adversos
[Mh] Termos MeSH secundário: Transtornos de Deglutição/epidemiologia
Transtornos de Deglutição/etiologia
Transtornos de Deglutição/fisiopatologia
Intervalo Livre de Doença
Relação Dose-Resposta à Radiação
Feminino
Neoplasias de Cabeça e Pescoço/patologia
Perda Auditiva/epidemiologia
Perda Auditiva/etiologia
Perda Auditiva/fisiopatologia
Seres Humanos
Masculino
Mandíbula/patologia
Mandíbula/efeitos da radiação
Osteonecrose/epidemiologia
Osteonecrose/etiologia
Osteonecrose/fisiopatologia
Prognóstico
Lesões por Radiação/epidemiologia
Tolerância a Radiação
Radioterapia/métodos
Dosagem Radioterapêutica
Medição de Risco
Análise de Sobrevida
Trismo/epidemiologia
Trismo/etiologia
Trismo/fisiopatologia
Xerostomia/epidemiologia
Xerostomia/etiologia
Xerostomia/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE


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[PMID]:28715432
[Au] Autor:Huang ZG; Gao BX; Chen H; Yang MX; Chen XL; Yan R; Lu X; Shi KN; Chan Q; Wang GC
[Ad] Endereço:Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
[Ti] Título:An efficacy analysis of whole-body magnetic resonance imaging in the diagnosis and follow-up of polymyositis and dermatomyositis.
[So] Source:PLoS One;12(7):e0181069, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To evaluate the value of whole-body magnetic resonance imaging (WBMRI) in diagnosing muscular and extra muscular lesions in patients with polymyositis (PM) and dermatomyositis (DM). METHODS: A retrospective analysis of WBMRI data from PM/DM patients who met the Bohan and Peter diagnostic criteria was performed. X2 test was used to compare the rate of positive diagnosis of newly diagnosed patients using WBMRI, serum creatine kinase test, and EMG. McNemar test was used to compare the performance of WBMRI and chest CT in detecting interstitial lung disease (ILD). RESULTS: The study included 129 patients (30 PM cases and 99 DM cases). Of them, 81.4% (105/129) showed a visible inflammatory muscular edema on their WBMRI; 29.5% (38/129) had varying degrees of fatty infiltration (9 cases with clear muscular atrophy). Of the 66 newly diagnosed patients, the positive rates of WBMRI, muscle biopsy, serum creatine kinase test and EMG were 86.4% (57/66), 92.4% (61/66), 71.2% (47/66) and 71.1% (32/45), respectively. There was no significant difference in the positive rates between WBMRI and muscle biopsy (X2 = 1.28, P = 0.258). The WBMRI had a higher positive rate than both serum creatine kinase test (X2 = 4.53, P = 0.033) and EMG (X2 = 3.92, P = 0.047). In addition to muscular changes, WBMRI also detected interstitial lung disease (ILD) in 38 cases (29.5%), osteonecrosis in 15 cases (11.6%), and neoplastic lesions (5 malignant; 7 benign) in 12 cases (9.3%). Of the 61 patients who underwent routine chest CT examinations, the WBMRI and CT revealed ILD in 29 cases and 35 cases respectively. There was no significant difference in the sensitivity between WBMRI and CT (p = 0.146). CONCLUSIONS: WBMRI is a sensitive, non-invasive and efficient imaging method. It comprehensively displays the extent of muscular involvement in PM/DM patients, and it has the ability to diagnose other associated extra muscular diseases, such as ILD and systemic malignancy. WBMRI can also help screen steroid-induced osteonecrosis.
[Mh] Termos MeSH primário: Dermatomiosite/diagnóstico por imagem
Imagem por Ressonância Magnética
Polimiosite/diagnóstico por imagem
Imagem Corporal Total
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Creatina Quinase/sangue
Dermatomiosite/complicações
Feminino
Seguimentos
Seres Humanos
Doenças Pulmonares Intersticiais/complicações
Doenças Pulmonares Intersticiais/diagnóstico
Masculino
Meia-Idade
Músculos/patologia
Neoplasias Nasofaríngeas/diagnóstico
Neoplasias Nasofaríngeas/diagnóstico por imagem
Osteonecrose/complicações
Osteonecrose/diagnóstico
Osteonecrose/diagnóstico por imagem
Polimiosite/complicações
Estudos Retrospectivos
Tórax/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.3.2 (Creatine Kinase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181069


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[PMID]:28685531
[Au] Autor:Lechner J; Huesker K; Von Baehr V
[Ad] Endereço:Clinic for Integrative Dentistry, Munich, Germany.
[Ti] Título:Impact of Rantes from jawbone on Chronic Fatigue Syndrome.
[So] Source:J Biol Regul Homeost Agents;31(2):321-327, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:This study elucidates the question of whether chronic inflammation in the jawbone contributes to the development of Chronic Fatigue Syndrome (CFS). Fatty degenerative osteonecrosis in jawbone (FDOJ) may contribute to CFS by induction of inflammatory mediators. We examined seven cytokines by multiplex analysis in jawbone samples from two groups of patients. In order to clarify neurological interrelations, specimens from 21 CFS patients were analyzed from areas of previous surgery in the retromolar wisdom tooth area. Each of the retromolar jawbone samples showed clinically fatty degenerated and osteonecrotic medullary changes. As control, healthy jawbone specimens from 19 healthy patients were analyzed. All fatty necrotic and osteolytic jawbone (FDOJ) samples showed high expression of RANTES and fibroblast growth factor (FGF)-2. FDOJ cohorts showed a 30-fold mean overexpression of RANTES and a 20-fold overexpressed level of FGF-2 when compared to healthy controls. As RANTES is discussed in the literature as a possible contributor to inflammatory diseases, we hypothesize that FDOJ in areas of improper and incomplete wound healing in the jawbone may hyperactivate signaling pathways. Constituting a hidden source of “silent inflammation” FDOJ may represent a hitherto unknown cause for the development of CFS.
[Mh] Termos MeSH primário: Quimiocina CCL5/biossíntese
Síndrome de Fadiga Crônica/metabolismo
Doenças Maxilomandibulares/metabolismo
Arcada Osseodentária/metabolismo
Osteonecrose/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Síndrome de Fadiga Crônica/patologia
Feminino
Fator 2 de Crescimento de Fibroblastos/biossíntese
Seres Humanos
Arcada Osseodentária/patologia
Doenças Maxilomandibulares/patologia
Masculino
Meia-Idade
Osteonecrose/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (CCL5 protein, human); 0 (Chemokine CCL5); 103107-01-3 (Fibroblast Growth Factor 2)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE



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