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[PMID]:28328825
[Au] Autor:Park JH; Hong JY; Han K; Suh SW; Park SY; Yang JH; Han SW
[Ad] Endereço:aDepartment of Orthopedics, Korea University Ansan Hospital, Ansan bDepartment of Biostatistics, College of Medicine, Catholic University cDepartment of Orthopedics, Korea University Guro Hospital dDepartment of Orthopedics, Korea University Anam Hospital, Seoul, South Korea.
[Ti] Título:Prevalence of symptomatic hip, knee, and spine osteoarthritis nationwide health survey analysis of an elderly Korean population.
[So] Source:Medicine (Baltimore);96(12):e6372, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Osteoarthritis is prominent among the elderly, with symptoms originating from multiple parts of the body. A cross-sectional study of a nationwide survey was performed to describe the prevalence of and identify factors related to symptomatic hip, knee, and spine osteoarthritis.This cross-sectional study collected data from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V-5; 2010-2012). After excluding ineligible subjects, there were 8976 subjects in this study (3830 males and 5146 females). All subjects reported symptoms and disabilities related to osteoarthritis. Plain radiographs of the spine, hip, and knee were taken in all subjects.Overall, 9.3% of male participants and 28.5% of female participants were diagnosed with symptomatic osteoarthritis according to survey criteria. Women showed a significantly higher prevalence in all age groups (P < 0.05). Multiple-joint osteoarthritis was diagnosed in 10.8% of male patients and 22.8% of female patients with osteoarthritis. Several demographic and lifestyle variables were related to osteoarthritis morbidity. Anthropometric and laboratory measurements were also related to osteoarthritis morbidity. In addition, mental distress and quality of life were significantly compromised in osteoarthritis. There were more significant relationships for these factors among women with a higher prevalence of multijoint osteoarthritis.A significant proportion of the elderly with single- or multiple-joint osteoarthritis had a variety of pain origins that were closely related. Osteoarthritis was also significantly related to several factors, including mental distress and quality of life.
[Mh] Termos MeSH primário: Osteoartrite do Quadril/epidemiologia
Osteoartrite do Joelho/epidemiologia
Osteoartrite da Coluna Vertebral/epidemiologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Antropometria
Estudos Transversais
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Coreia (Geográfico)/epidemiologia
Estilo de Vida
Masculino
Meia-Idade
Osteoartrite do Quadril/diagnóstico por imagem
Osteoartrite do Quadril/psicologia
Osteoartrite do Joelho/diagnóstico por imagem
Osteoartrite do Joelho/psicologia
Osteoartrite da Coluna Vertebral/diagnóstico por imagem
Osteoartrite da Coluna Vertebral/psicologia
Prevalência
Qualidade de Vida
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170412
[Lr] Data última revisão:
170412
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006372


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[PMID]:27848263
[Au] Autor:Russo VM; Duits A; Dhawan RT; Casey AT
[Ad] Endereço:a Department of Neurosurgery , The National Hospital for Neurology and Neurosurgery , London , UK.
[Ti] Título:Joint arthropathy at the cranio-vertebral junction. Scintigraphic patterns on bone SPECT/CT.
[So] Source:Br J Neurosurg;31(1):45-49, 2017 Feb.
[Is] ISSN:1360-046X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Osteoarthritic degeneration at the cranio-vertebral junction (CVJ) is an underrecognized source of suboccipital and neck pain, limited range of motion and cervicogenic headaches. Correlation of radiographic findings with clinical symptoms is often difficult. Limited evidence currently exists to support the use of bone single-photon emission computed tomography/computed tomography (SPECT/CT) in this subgroup of patients. The aim of this study was to describe the scintigraphic patterns of joint arthropathy at the CVJ on bone SPECT/CT in patients with suboccipital/neck pain and cervicogenic headache. Patients with more than 3 months of suboccipital/neck pain/cervicogenic headache and abnormal SPECT/CT findings at the CVJ were included. Patients with known/suspected malignancy, trauma, infectious processes and previous surgery at the CVJ were excluded. Neck disability index (NDI), visual analogue scale (VAS) and treatment were recorded for each patient. Patterns of osteoblastic activity at the CVJ on bone SPECT/CT were described and correlated with arthritic changes on conventional scans. Eighteen patients were included (10 females, mean age 68). Mean NDI score was 22. Mean VAS was 7.5. On bone SPECT/CT, it was found that 13 patients had high osteoblastic activity unilaterally at the atlanto-axial joint (AAJ); two patients at the atlanto-dental joint (ADJ), one at the occipito-atlantal joint (OAJ), one at both OAJ and ADJ and one at the level of C2 pars/pedicle unilaterally. Metabolic activity on SPECT/CT was associated with severe degenerative changes on CT scans. The ability of hybrid bone SPECT/CT to precisely localize osteoblastic activity at the CVJ may provide significant improvement in the diagnosis and treatment of patients with suboccipital/neck pain and joint arthropathy at the CVJ. Further clinical studies are needed to establish the real clinical impact of bone SPECT/CT in the treatment of patients with suboccipital neck pain.
[Mh] Termos MeSH primário: Articulação Atlantoaxial/diagnóstico por imagem
Articulação Atlantoccipital/diagnóstico por imagem
Osteoartrite da Coluna Vertebral/diagnóstico por imagem
Tomografia Computadorizada de Emissão de Fóton Único/métodos
[Mh] Termos MeSH secundário: Idoso
Difosfonatos
Avaliação da Deficiência
Feminino
Cefaleia/diagnóstico por imagem
Cefaleia/etiologia
Seres Humanos
Masculino
Cervicalgia/diagnóstico por imagem
Cervicalgia/etiologia
Compostos de Organotecnécio
Osteoartrite da Coluna Vertebral/complicações
Medição da Dor
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diphosphonates); 0 (Organotechnetium Compounds); 0 (Radiopharmaceuticals); 0 (technetium Tc 99m hydroxydiphosphonate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE
[do] DOI:10.1080/02688697.2016.1226254


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[PMID]:26825659
[Au] Autor:Pariente E; Olmos JM; Landeras R; Nan D; González-Macías J; Hernández JL
[Ad] Endereço:"Camargo-Interior" Primary Care Center, Servicio Cántabro de Salud, OSPC, Muriedas, Cantabria, Spain.
[Ti] Título:Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study.
[So] Source:J Bone Miner Metab;35(1):114-121, 2017 Jan.
[Is] ISSN:1435-5604
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Spinal osteoarthritis has been suggested as a risk factor for vertebral fractures. However, results are conflicting: most of the data are focused on the lumbar region, and referred to postmenopausal women, whereas data for men are scarce. The aim of this study is to assess the relationship between spinal osteoarthritis and vertebral fractures in men over 50 years of age. We conducted a cross-sectional study, nested in a prospective population-based cohort, including 507 community-dwelling men, 93 of them with at least one vertebral fracture. Vertebral fractures, osteophytosis, and disc space narrowing (DSN) were assessed by lateral thoracic and lumbar radiographs. Anthropometric, clinical, and densitometric variables were also analyzed. A multiple logistic regression model was performed. Eighty-five percent of vertebral fractures were located at the thoracic spine. Osteophytosis and DSN showed a bimodal distribution, with major frequency peaks at mid- and distal lumbar spine. The three distributions overlapped around the T9 vertebra. We did not find any relationship between lumbar osteoarthritis and vertebral fractures. Nevertheless, thoracic osteophytosis (OR, 1.84; 95 % CI, 1.05-3.17; p = 0.03) and DSN (OR, 2.52; 95 % CI, 1.43-4.46; p = 0.001) were found to be independently associated with prevalent vertebral fractures, after adjusting for confounders. Our results suggest a positive relationship between radiologic osteoarthritic changes at the thoracic spine and prevalent vertebral fractures in men more than 50 years of age. Osteoarthritis may act as a local risk factor, in addition to other mechanical factors, resulting in a greater propensity to fracture, especially at the mid-thoracic region.
[Mh] Termos MeSH primário: Vértebras Lombares
Osteoartrite da Coluna Vertebral
Fraturas da Coluna Vertebral
Osteofitose Vertebral
Vértebras Torácicas
[Mh] Termos MeSH secundário: Idoso
Estudos Transversais
Feminino
Seres Humanos
Vértebras Lombares/diagnóstico por imagem
Vértebras Lombares/metabolismo
Masculino
Meia-Idade
Osteoartrite da Coluna Vertebral/complicações
Osteoartrite da Coluna Vertebral/diagnóstico por imagem
Osteoartrite da Coluna Vertebral/epidemiologia
Osteoartrite da Coluna Vertebral/metabolismo
Estudos Prospectivos
Fraturas da Coluna Vertebral/diagnóstico por imagem
Fraturas da Coluna Vertebral/epidemiologia
Fraturas da Coluna Vertebral/etiologia
Fraturas da Coluna Vertebral/metabolismo
Osteofitose Vertebral/diagnóstico por imagem
Osteofitose Vertebral/epidemiologia
Osteofitose Vertebral/etiologia
Osteofitose Vertebral/metabolismo
Vértebras Torácicas/diagnóstico por imagem
Vértebras Torácicas/metabolismo
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160131
[St] Status:MEDLINE
[do] DOI:10.1007/s00774-016-0735-1


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[PMID]:27744005
[Au] Autor:Toosizadeh N; Harati H; Yen TC; Fastje C; Mohler J; Najafi B; Dohm M
[Ad] Endereço:Arizona Center on Aging, Department of Medicine, University of Arizona, Tucson, AZ, USA; Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA.
[Ti] Título:Paravertebral spinal injection for the treatment of patients with degenerative facet osteoarthropathy: Evidence of motor performance improvements based on objective assessments.
[So] Source:Clin Biomech (Bristol, Avon);39:100-108, 2016 Nov.
[Is] ISSN:1879-1271
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study examined short- and long-term improvements in motor performance, quantified using wearable sensors, in response to facet spine injection in degenerative facet osteoarthropathy patients. METHODS: Adults with confirmed degenerative facet osteoarthropathy were recruited and were treated with medial or intermediate branch block injection. Self-report pain, health condition, and disability (Oswestry), as well as objective motor performance measures (gait, balance, and timed-up-and-go) were obtained in five sessions: pre-surgery (baseline), immediately after the injection, one-month, three-month, and 12-month follow-ups. Baseline motor performance parameters were compared with 10 healthy controls. FINDINGS: Thirty patients (age=50 (14) years) and 10 controls (age=46 (15) years) were recruited. All motor performance parameters were significantly different between groups. Results showed that average pain and Oswestry scores improved by 51% and 24%, respectively among patients, only one month after injection. Similarly, improvement in motor performance was most noticeable in one-month post-injection measurements; most improvements were observed in gait speed (14% normal walking, P<0.02), hip sway within balance tests (63% eyes-open P<0.01), and turning velocity within the timed-up-and-go test (28%, P<0.02). Better baseline motor performance led to better outcomes in terms of pain relief; baseline turning velocity was 18% faster among the responsive compared to the non-responsive patients. INTERPRETATIONS: Spinal injection can temporarily (one to three months) improve motor performance in degenerative facet osteoarthropathy patients. Successful pain relief in response to treatment is independent of demographic characteristics and initial pain but dependent on baseline motor performance. Immediate self-reported pain relief is unrelated to magnitude of gradual improvement in motor performance.
[Mh] Termos MeSH primário: Anestésicos Locais/administração & dosagem
Glucocorticoides/administração & dosagem
Dor Lombar/tratamento farmacológico
Atividade Motora/fisiologia
Osteoartrite da Coluna Vertebral/tratamento farmacológico
Osteoartrite da Coluna Vertebral/fisiopatologia
[Mh] Termos MeSH secundário: Bupivacaína/administração & dosagem
Feminino
Marcha/fisiologia
Seres Humanos
Injeções Espinhais
Lidocaína/administração & dosagem
Dor Lombar/etiologia
Masculino
Meia-Idade
Equilíbrio Postural/fisiologia
Resultado do Tratamento
Triancinolona/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Glucocorticoids); 1ZK20VI6TY (Triamcinolone); 98PI200987 (Lidocaine); Y8335394RO (Bupivacaine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161017
[St] Status:MEDLINE


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[PMID]:27333727
[Au] Autor:Jelec V; Turner R; Franic M; Korusic A; Rotim K
[Ti] Título:FACET ORIENTATION AND TROPISM: ASSOCIATION WITH ACCELERATED DEGENERATION OF STABILIZING STRUCTURES IN LOWER LUMBAR SPINE.
[So] Source:Acta Clin Croat;55(1):117-24, 2016 Mar.
[Is] ISSN:0353-9466
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:The influence of facet orientation and tropism on the process of spinal degeneration has been extensively studied during the last few decades, but there are still many controversies and conflicting results in this field of research. The biomechanical cause of accelerated degeneration of stabilizing structures in lower lumbar spine lies within the combination of several factors, but two most important ones are compressive load and more coronal facet orientation that offers less resistance against torsional loading. Axial rotation of lower lumbar spine is undoubtedly associated with higher strain in disc annulus, and enhanced range of secondary rotational movements may be even more significant for the progression of annular degeneration. Accordingly, more pronounced facet tropism could be having part in faster progression of disc degeneration in lower lumbar spine, as indicated by a number of recent studies. More sagittal facet orientation in patients with a higher facet osteoarthritis score at lower lumbar segments is very likely related to arthritic remodeling commonly seen in other synovial joints. There is also a possibility that it could be associated with the adaptation to partial loss of lumbar lordosis, as both coincide with advanced age.
[Mh] Termos MeSH primário: Degeneração do Disco Intervertebral/patologia
Disco Intervertebral/patologia
Vértebras Lombares/patologia
Osteoartrite da Coluna Vertebral/patologia
Articulação Zigapofisária/patologia
[Mh] Termos MeSH secundário: Fenômenos Biomecânicos
Seres Humanos
Disco Intervertebral/fisiopatologia
Degeneração do Disco Intervertebral/fisiopatologia
Vértebras Lombares/fisiopatologia
Imagem por Ressonância Magnética
Osteoartrite da Coluna Vertebral/fisiopatologia
Tropismo
Suporte de Carga
Articulação Zigapofisária/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160623
[Lr] Data última revisão:
160623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE


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[PMID]:27333712
[Au] Autor:Mustapic M; Viskovic K; Boric I; Marjan D; Zadravec D; Begovac J
[Ti] Título:VERTEBRAL OSTEOMYELITIS IN ADULT PATIENTS--CHARACTERISTICS AND OUTCOME.
[So] Source:Acta Clin Croat;55(1):9-15, 2016 Mar.
[Is] ISSN:0353-9466
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to assess disease characteristics and outcome in patients with vertebral osteomyelitis (VO). A two medical centre retrospective cohort study was performed by chart review after discharge of 110 patients with confirmed VO treated during a 5-year period. Patients were divided in two groups: patients with uncomplicated VO and patients with complicated VO. All patients underwent clinical and biological examinations and magnetic resonance imaging (MRI) according to the same protocol. Patients with complicated VO were significantly older (p = 0.038). They were longer treated with antibiotics parenterally (p = 0.047) and more often surgically (p < 0.001). In these patients, high Charlson comorbidity index (CCI) score was more often observed (p = 0.024), as well as liver cirrhosis (p = 0.013) and degenerative spine disease (p = 0.007) as comorbidities. Patients with advanced MRI changes of VO had a modified CCI score of 2 or more (p = 0.006). They more often experienced neurological deficit (p = 0.021). Staphylococcus aureus was the most frequently isolated bacterium from blood and tissue samples. Advanced MRI changes and complicated VO were more often observed in patients with high CCI score due to impaired immune system caused by chronic comorbid disease(s) or modulation of immunity with medications. High CCI scores were more frequently associated with positive blood cultures due to bacteremia because of impaired immunity. Patients with complicated VO were longer treated with antibiotics parenterally and more often surgically treated for phlegmon and abscess formation. Liver cirrhosis and degenerative spine disease, which were more often found in patients with complicated VO, obviously impacted the course of the disease.
[Mh] Termos MeSH primário: Osteomielite/diagnóstico
Doenças da Coluna Vertebral/diagnóstico
Infecções Estafilocócicas/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Antibacterianos/uso terapêutico
Estudos de Coortes
Comorbidade
Feminino
Seres Humanos
Degeneração do Disco Intervertebral/epidemiologia
Cirrose Hepática/epidemiologia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Osteoartrite da Coluna Vertebral/epidemiologia
Osteomielite/tratamento farmacológico
Osteomielite/epidemiologia
Osteomielite/microbiologia
Prognóstico
Estudos Retrospectivos
Doenças da Coluna Vertebral/tratamento farmacológico
Doenças da Coluna Vertebral/epidemiologia
Doenças da Coluna Vertebral/microbiologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/epidemiologia
Staphylococcus aureus
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160623
[Lr] Data última revisão:
160623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE


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[PMID]:27268310
[Au] Autor:Urakov TM; Casabella AM; Levene HB
[Ad] Endereço:Department of Neurological Surgery, University of Miami, Miller School of Medicine, Miami, Florida, USA. Electronic address: timur.urakov@jhsmiami.org.
[Ti] Título:Percutaneous Drainage of Chronic Destructive Lumbar Osteomyelitis Abscess Via the Use of Bilateral Transpedicular Trocar Access.
[So] Source:World Neurosurg;92:583.e1-5, 2016 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pyogenic spondylodiskitis is an infection of intervertebral disks and spinal vertebral bodies. Various minimally invasive approaches to the infected disk spaces/abscesses have been described for management of early stages of the infection. Patients with chronic occurrence present with extensive infection, neurologic deficits, and bone destruction. Such patients commonly have substantial medical comorbidities. Despite the increased risks of complications, they often are treated with open surgical approaches without minimally invasive options. We describe a bilateral transpedicular approach to vertebral body abscess in a chronically infected patient with intraoperative contiguous irrigation. CASE DESCRIPTION: We present 2 cases, a 58-year-old man and a 61-year-old man, both with a diagnosis of vertebral osteomyelitis. Images of lumbar spine showed epidural abscess and adjacent vertebral body destruction. Because of their poor clinical condition and chronicity of disease, these patients underwent percutaneous bilateral transpedicular approach. CONCLUSION: Patients in poor health and with chronic vertebral osteomyelitis may benefit from minimally invasive percutaneous transpedicular drainage and irrigation of the abscess, representing a minimally invasive and effective treatment alternative for these patients.
[Mh] Termos MeSH primário: Drenagem/instrumentação
Drenagem/métodos
Osteoartrite da Coluna Vertebral/reabilitação
Osteoartrite da Coluna Vertebral/cirurgia
Instrumentos Cirúrgicos
Irrigação Terapêutica/métodos
[Mh] Termos MeSH secundário: Fluoroscopia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Osteoartrite da Coluna Vertebral/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:27147479
[Au] Autor:Netzer C; Urech K; Hügle T; Benz RM; Geurts J; Schären S
[Ad] Endereço:Spine Surgery, University Hospital Basel, Spitalstrasse 21, Basel 4031, Switzerland.
[Ti] Título:Characterization of subchondral bone histopathology of facet joint osteoarthritis in lumbar spinal stenosis.
[So] Source:J Orthop Res;34(8):1475-80, 2016 Aug.
[Is] ISSN:1554-527X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Facet joint osteoarthritis may be a cause of low back pain in degenerative spine diseases including lumbar spinal stenosis. Subchondral bone is regarded as a potential therapeutic target for osteoarthritis treatment. The goal of this study was to characterize subchondral bone histopathology in osteoarthritic facet joints from lumbar spinal stenosis patients. Fifteen patients with degenerative spinal stenosis scheduled for transforaminal lumbar interbody fusion surgery were recruited for this study. Osteoarthritis severity was graded on T1- and T2-weighted MRI images using Weishaupt scoring system. Dissected osteoarthritic facet joints were subjected to histological and immunohistochemistry analyses to study relative abundance of osteoblast, osteoclasts, and macrophages using van Gieson's, tartrate-resistant acid phosphatase and CD68-antibody staining, respectively. Presence of nerve fibers was evaluated by PGP9.5-antibody staining. Differential bone histopathology, independent from radiological osteoarthritis grade, was observed in facet joints. Extensive de novo bone formation was found in subchondral bone tissues of eight of fifteen specimens. Regions of bone formation showed high abundance of blood vessels and CD68-positive macrophages, but were devoid of multinucleated osteoclasts. Additional pathological changes in subchondral marrow spaces, including inflammatory infiltration and enhanced osteoclast activity, were characterized by macrophage-rich tissues. PGP9.5-positive nerve fibers were detected near arterioles, but not in regions displaying bone pathology. Individual histopathological parameters did not associate with clinical features or radiological osteoarthritis severity. Subchondral bone histopathology of facet joint osteoarthritis in lumbar spinal stenosis is characterized by marrow infiltration by macrophage-rich tissues and enhanced de novo bone formation. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1475-1480, 2016.
[Mh] Termos MeSH primário: Vértebras Lombares/patologia
Osteoartrite da Coluna Vertebral/patologia
Estenose Espinal/complicações
Articulação Zigapofisária/patologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Colágeno/metabolismo
Feminino
Seres Humanos
Vértebras Lombares/irrigação sanguínea
Vértebras Lombares/inervação
Vértebras Lombares/metabolismo
Macrófagos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Osteoartrite da Coluna Vertebral/complicações
Osteoartrite da Coluna Vertebral/diagnóstico por imagem
Osteoartrite da Coluna Vertebral/metabolismo
Osteoblastos
Osteoclastos
Estudos Retrospectivos
Estenose Espinal/diagnóstico por imagem
Articulação Zigapofisária/irrigação sanguínea
Articulação Zigapofisária/inervação
Articulação Zigapofisária/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9007-34-5 (Collagen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1002/jor.23281


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[PMID]:27111225
[Au] Autor:Bleil J; Maier R; Hempfing A; Sieper J; Appel H; Syrbe U
[Ad] Endereço:Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
[Ti] Título:Granulation Tissue Eroding the Subchondral Bone Also Promotes New Bone Formation in Ankylosing Spondylitis.
[So] Source:Arthritis Rheumatol;68(10):2456-65, 2016 Oct.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We previously suggested that fibroblast-rich granulation tissue eroding the subchondral bone is instrumental in the joint remodeling that occurs in ankylosing spondylitis (AS). The purpose of this study was to determine if this granulation tissue also carries bone-forming capabilities, which we approached by searching for bone-forming cells (hypertrophic chondrocytes, osteoblasts) in its vicinity. We also assessed adipogenic tissue transformation, which has been suggested to be an intermediate feature in AS bone formation based on imaging studies. METHODS: The facet joints of AS patients, osteoarthritis (OA) patients, and autopsy subjects (controls) were screened for subchondral granulation tissue. We searched for hypertrophic chondrocytes by assessing RUNX-2, type X collagen, and matrix metalloproteinase 13 (MMP-13) expression, for osteoblasts by analyzing RUNX-2, CD56, and type I collagen expression, as well as for signs of new bone formation. Adipocytes and lipid accumulation were assessed in Safranin O-stained sections. RESULTS: In the joints of AS and OA patients, RUNX-2-positive cells were found to be lining the granulation tissue. These cells coexpressed type I collagen but lacked type X collagen and MMP-13 expression, confirming their osteoblastic nature. In 91% of AS joints and in 20% of OA joints (P < 0.05), we observed foci of new bone formation at contact zones between the granulation tissue and the cartilage. Joints containing bony spots showed greater replacement of the adjacent bone marrow by granulation tissue than did joints without bone formation (P < 0.05). The granulation tissue often contained adipocytes and lipid accumulations. Replacement of the subchondral bone marrow by fat tissue was also frequently found but was not associated with new bone formation. CONCLUSION: The subchondral granulation tissue carries osteoblasts, which promote new bone formation, leading to intraarticular ankylosis of the facet joints in AS.
[Mh] Termos MeSH primário: Condrócitos/patologia
Tecido de Granulação/patologia
Osteoartrite da Coluna Vertebral/patologia
Osteoblastos/patologia
Osteogênese
Coluna Vertebral/patologia
Espondilite Anquilosante/patologia
Articulação Zigapofisária/patologia
[Mh] Termos MeSH secundário: Adipócitos/metabolismo
Adipócitos/patologia
Adipogenia
Adulto
Idoso
Idoso de 80 Anos ou mais
Antígeno CD56/metabolismo
Estudos de Casos e Controles
Condrócitos/metabolismo
Colágeno Tipo I/metabolismo
Colágeno Tipo X/metabolismo
Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo
Feminino
Tecido de Granulação/metabolismo
Seres Humanos
Masculino
Metaloproteinase 13 da Matriz/metabolismo
Meia-Idade
Osteoartrite da Coluna Vertebral/metabolismo
Osteoblastos/metabolismo
Coluna Vertebral/metabolismo
Espondilite Anquilosante/metabolismo
Articulação Zigapofisária/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD56 Antigen); 0 (Collagen Type I); 0 (Collagen Type X); 0 (Core Binding Factor Alpha 1 Subunit); 0 (NCAM1 protein, human); 0 (RUNX2 protein, human); EC 3.4.24.- (MMP13 protein, human); EC 3.4.24.- (Matrix Metalloproteinase 13)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE
[do] DOI:10.1002/art.39715


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[PMID]:26991429
[Au] Autor:Hong JY; Han K; Shin DH; Chun EM
[Ad] Endereço:Department of Orthopedics, Korea University Ansan Hospital, Ansan, South Korea.
[Ti] Título:Quality of Life Analysis and Smoking Correlation in Symptomatic Spine Osteoarthritis: A Nationwide Health Survey Analysis of an Elderly Population with EQ-5D.
[So] Source:PLoS One;11(3):e0151315, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To analyze quality of life in people with symptomatic spine osteoarthritis (OA) using the results of a cross-sectional, nationwide survey. MATERIALS AND METHODS: This study used data from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V-5; 2010-2012). After excluding ineligible subjects, the total number of subjects in the study was 8,963, including 4,091 males and 4,872 females. All participants reported disabilities related to spine OA. Plain radiographs of the spine were taken for all participants. RESULTS: Age, sex, smoking, drinking, education, and income level were significantly related to spine OA morbidity (P<0.05). OA morbidity was significantly higher in female ex-smokers (OR; 2.94, P<0.05). Quality of life (EQ-5D: L1~5) was significantly compromised in the group with spine OA compared to the group without spine OA (P<0.05). Overall, LQ 1, 2, 3, 4, and 5 domain scores were significantly higher in the group with spine OA (P<0.05). In the group with spine OA, quality of life was reduced on more than three questions for 34.3% of the group (EQ-5D: grade≥2); on two questions, for 18.5% of the group; and on one question, for 11.1% of the group. Mental stress, melancholy, and suicidal thinking were also more common in the group with spine OA (P<0.05). The group with radiographic spine OA but without symptoms did not have compromised EQ-5D scores, whereas the group with radiographic OA and symptoms showed a significantly reduced quality of life. CONCLUSIONS: Quality of life was significantly reduced in the group with symptomatic spine OA in a large cross-sectional analysis. Physicians should consider quality of life in the treatment of patients with spine OA.
[Mh] Termos MeSH primário: Osteoartrite da Coluna Vertebral/etiologia
Qualidade de Vida
Fumar
[Mh] Termos MeSH secundário: Atividades Cotidianas
Idoso
Estudos de Casos e Controles
Estudos Transversais
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Osteoartrite da Coluna Vertebral/diagnóstico por imagem
Osteoartrite da Coluna Vertebral/epidemiologia
Radiografia
República da Coreia
Autocuidado/estatística & dados numéricos
Fumar/epidemiologia
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0151315



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