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[PMID]:28453761
[Au] Autor:Karreman MC; Luime JJ; Hazes JMW; Weel AEAM
[Ad] Endereço:Erasmus University Medical Center, Wytemaweg 80, Rotterdam, The Netherlands.
[Ti] Título:The Prevalence and Incidence of Axial and Peripheral Spondyloarthritis in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.
[So] Source:J Crohns Colitis;11(5):631-642, 2017 May 01.
[Is] ISSN:1876-4479
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and Aims: Inflammatory bowel disease [IBD] is a chronic disease which affects up to 0.5% of the population. Various extraintestinal manifestations occur, among which are rheumatic manifestations, grouped together under the name spondyloarthritis. The objective of this systematic review and meta-analysis was to give a systematic overview of the prevalence and incidence of spondyloarthritis in patients with inflammatory bowel disease. Methods: We systematically searched Embase, Pubmed, OvidSP, Scopus, and Web-of-Science databases from inception to August 2016. All articles that addressed the prevalence or incidence of the different features of spondyloarthritis in adult inflammatory bowel disease patients were included. Methodological quality was assessed using a modified quality assessment tool developed for prevalence studies. Results: A total of 71 studies were included, reporting on the prevalence of sacroiliitis, ankylosing spondylitis, arthritis, enthesitis, and dactylitis. Pooled prevalences were calculated for sacroiliitis (10%; 95% confidence interval [CI] 8-12%), ankylosing spondylitis [3%; 95% CI 2-4%], and arthritis [13%; 95% CI 12-15%]. Geographical area, setting and use of different criteria contribute to the large heterogeneity. Few estimates were available for enthesitis [prevalence range from 1% to 54%] and dactylitis [prevalence range from 0% to 6%]. Only three incidence studies were identified, which report cumulative incidences from 5 to 30 years. Conclusions: Spondyloarthritis occurs in up to 13% of patients with IBD. Ankylosing spondylitis is the least common [3%] followed by sacroiliitis [10%] and peripheral arthritis [13%].
[Mh] Termos MeSH primário: Doenças Inflamatórias Intestinais/complicações
Espondilartrite/complicações
[Mh] Termos MeSH secundário: Artrite/complicações
Artrite/epidemiologia
Seres Humanos
Incidência
Prevalência
Sacroileíte/complicações
Sacroileíte/epidemiologia
Espondilartrite/epidemiologia
Espondilite Anquilosante/complicações
Espondilite Anquilosante/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/ecco-jcc/jjw199


  2 / 12166 MEDLINE  
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[PMID]:29465556
[Au] Autor:Ni Y; Jiang C
[Ad] Endereço:Department of Spine Surgery.
[Ti] Título:Identification of potential target genes for ankylosing spondylitis treatment.
[So] Source:Medicine (Baltimore);97(8):e9760, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to identify the potential target genes for the treatment of ankylosing spondylitis (AS).Dataset GSE25101 was downloaded from Gene Expression Omnibus, including 16 AS and 16 normal control blood samples. Differentially expressed genes (DEGs) were identified using unmatched t-test in limma package with adjusted P < .05. Gene ontology-biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted using multifaceted analysis tool for human transcriptome. Protein-protein interaction (PPI) network was constructed using STRING and Cytoscape, and module analysis was performed using MCODE plug-in. Webgestal was utilized to predict transcriptional factor (TF)-microRNA-target network and Comparative Toxicogenomics Database (CTD) was applied to predict chemical-target network.A total of 334 DEGs were identified, including 136 upregulated genes and 198 downregulated genes. According to STRING, a PPI network was constructed and 1 significant clustered module was screen out with score = 6.33. MAPK7 (degree = 11) and NDUFS4 (degree = 10) were 2 important nodes in PPI network, and both of them were significantly enriched in cAMP mediated signaling pathway (P = 2.02E-02). MAPK7 could be regulated by NFY. Both MAPK7 and NDUFS4 were 2 potential targets for Indomethacin.MAPK7 and NDUFS4 played important roles in the pathogenesis of AS via cAMP mediated signaling pathway. Both of them could be targeted by Indomethacin.
[Mh] Termos MeSH primário: Proteína Quinase 7 Ativada por Mitógeno/sangue
NADH Desidrogenase/sangue
Mapeamento de Interação de Proteínas/métodos
Mapas de Interação de Proteínas/genética
Espondilite Anquilosante/genética
[Mh] Termos MeSH secundário: Anti-Inflamatórios não Esteroides/farmacologia
Estudos de Casos e Controles
Análise por Conglomerados
Biologia Computacional
Redes Reguladoras de Genes
Seres Humanos
Indometacina/farmacologia
Transdução de Sinais/genética
Espondilite Anquilosante/sangue
Espondilite Anquilosante/tratamento farmacológico
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); EC 1.6.5.3 (NDUFS4 protein, human); EC 1.6.99.3 (NADH Dehydrogenase); EC 2.7.11.24 (MAPK7 protein, human); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 7); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009760


  3 / 12166 MEDLINE  
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[PMID]:29390254
[Au] Autor:Zhang M; Li XM; Wang GS; Tao JH; Chen Z; Ma Y; Li XP
[Ad] Endereço:Department of Rheumatology and Immunology, Anhui Provincial Hospital, Anhui Medical University, Hefei, PR China.
[Ti] Título:The association between ankylosing spondylitis and the risk of any, hip, or vertebral fracture: A meta-analysis.
[So] Source:Medicine (Baltimore);96(50):e8458, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ankylosing spondylitis (AS) is an inflammatory rheumatic disease and strongly associated with an increased risk of fractures. A great proportion of patients with AS are suffering from sustaining fractures and the aim of this study is to evaluate and quantify the association between the site of the fracture and AS by performing a meta-analysis. METHODS: A systematic literature search was performed on Medline database from 1966 to August 15, 2016 and Embase database from 1980 to August 15, 2016. Studies were evaluated by 2 independent reviewers and quantitative estimates regarding the association between ankylosing spondylitis and the risk of any, hip, or vertebral fracture were presented. After the heterogeneity of selected studies was assessed by using Cochran I statistics, the random effect model was used to combine effect size. Publication bias was measured by Egger and Begg's regression tests. RESULTS: A total of 6 articles were involved in our study. The results of meta-analysis revealed that AS was strongly associated with the risk of vertebral fracture (odds ratio [OR] = 4.25, 95% confidence interval [CI] = 1.07-7.42) and was not significantly associated with the risk of any fracture (OR=2.00, 95%CI = 0.94-3.06) or hip fracture (OR=1.28, 95%CI =0.16-2.40). CONCLUSION: In the present study, a general knowledge of the association between AS and the risk of 3 kinds of fractures were presented, which could improve the ways of prevention of fracture in the patients with AS.
[Mh] Termos MeSH primário: Fraturas Ósseas/etiologia
Fraturas do Quadril/etiologia
Fraturas da Coluna Vertebral/etiologia
Espondilite Anquilosante/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008458


  4 / 12166 MEDLINE  
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[PMID]:29278768
[Au] Autor:Tang Y; Yang P; Wang F; Xu H; Zong SY
[Ad] Endereço:Department of Clinical Laboratory, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu 215600, China.
[Ti] Título:Association of polymorphisms in ERAP1 and risk of ankylosing spondylitis in a Chinese population.
[So] Source:Gene;646:8-11, 2018 Mar 10.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To explore the association between five polymorphisms in endoplasmic reticulum associated aminopeptidase 1 (ERAP1) gene and risk of ankylosing spondylitis (AS) in a Chinese population. A case-control study enrolled 250 AS patients and 250 healthy controls was carried out. The genotypes of involved polymorphisms (rs27037, rs27038, rs469876, rs27044 and rs27980) in ERAP1 were detected by Sequenom Mass-Array platform. There were significant differences of the level of WBC (white blood cell), Platelets, CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) between AS patients and controls (P <0.05). There was statistically association between ERAP1 rs27044 polymorphism and risk of AS, and the carriers with rs27044 CG genotype have an increased the risk for AS (CG versus GG, OR=1.70, 95% CI=1.10-2.62, P=0.015). However, we found no evidence for the association of rs27037, rs469876, and rs27980 polymorphisms in ERAP1 with AS risk. Our findings indicated that ERAP1 rs27044 polymorphism was associated with the susceptibility of AS.
[Mh] Termos MeSH primário: Aminopeptidases/genética
Grupo com Ancestrais do Continente Asiático/genética
Antígenos de Histocompatibilidade Menor/genética
Polimorfismo de Nucleotídeo Único
Espondilite Anquilosante/genética
[Mh] Termos MeSH secundário: Adulto
Grupo com Ancestrais do Continente Asiático/etnologia
Estudos de Casos e Controles
China/etnologia
Feminino
Estudos de Associação Genética
Predisposição Genética para Doença
Seres Humanos
Masculino
Meia-Idade
Análise de Sequência de DNA
Espondilite Anquilosante/etnologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minor Histocompatibility Antigens); EC 3.4.11.- (Aminopeptidases); EC 3.4.11.- (ERAP1 protein, human)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE


  5 / 12166 MEDLINE  
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[PMID]:28462791
[Au] Autor:Chon H; Park JH
[Ad] Endereço:Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
[Ti] Título:Cervical vertebral body fracture with ankylosing spondylitis treated with cervical pedicle screw: A fracture body overlapping reduction technique.
[So] Source:J Clin Neurosci;41:150-153, 2017 Jul.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:We describe a patient with ankylosing spondylitis (AS) with cervical spinal fracture treated with cervical pedicle screw placement (CPS) through a single posterior approach. A 43-year-old male patient with AS visited our emergency centre due to paralysis following a trauma. Coronal reconstructed cervical spine computed tomography (CT) scan showed a C5 oblique fracture, and the bilateral pedicles were separated superiorly and inferiorly. The sagittal reconstructed CT image revealed bamboo spine and C5 vertebrae body fracture. Hyperextension between the fractured segments of the C5 body was noted because the fracture gap was anteriorly open. Magnetic resonance imaging (MRI) showed cord compression and injury at the C4-5 level. CPS was performed at the C3-6 levels. Because the left and right pedicles were displaced superiorly and inferiorly, dual compressions between the left C5 and left C6 pedicle screws and between the right C5 and right C4 pedicle screws were performed. Decompression at the C4 and C5 levels was performed after identifying good alignment. This posterior fusion surgery was performed for two hours. After surgery, the radiograph showed complete reduction and fracture gap apposition. The patient was rehabilitated, and his muscle strength improved. Postoperative CT and X-rays revealed complete fracture site fusion and correct CPS position. Considering increased morbidity of long-level or -duration surgery, our fracture body overlapping technique using CPS and posterior only approach seems to be a possible and good surgical method in traumatic cervical fracture with AS.
[Mh] Termos MeSH primário: Vértebras Cervicais/cirurgia
Fixação de Fratura/métodos
Parafusos Pediculares/efeitos adversos
Fraturas da Coluna Vertebral/cirurgia
Fusão Vertebral/métodos
Espondilite Anquilosante/cirurgia
[Mh] Termos MeSH secundário: Adulto
Fixação de Fratura/efeitos adversos
Fixação de Fratura/instrumentação
Seres Humanos
Masculino
Fusão Vertebral/efeitos adversos
Fusão Vertebral/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  6 / 12166 MEDLINE  
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[PMID]:29202535
[Au] Autor:Ma H; Sun F; Zhang YM; Zhang H; Zhu J; Deng XH; Zhang JL; Huang F
[Ad] Endereço:Department of Rheumatology, Chinese PLA General Hospital, Beijing 100853, China.
[Ti] Título:[The safety and efficacy of golimumab in treatment of 25 patients with active ankylosing spondylitis].
[So] Source:Zhonghua Nei Ke Za Zhi;56(12):935-939, 2017 Dec 01.
[Is] ISSN:0578-1426
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To evaluate the efficacy and safety of golimumab in patients with active ankylosing spondylitis (AS). This was a randomized, double-blind, placebo-controlled trial. The subjects were randomized to receive either golimumab 50mg subcutaneously or placebo every 4 weeks. Patients in both groups received golimumab 50mg from week 24 to week 48. The primary endpoint was the proportion of at least 20% improvement in the Assessment of Spondyloarthritis International Society (ASAS20) at week 14. The secondary endpoints included at least 40% improvement in the Assessment of Spondyloarthritis International Society (ASAS40), ASAS partial-remission, Bath AS functional index, Bath AS disease activity index, Bath AS metrology index, enthesitis index and Jenkins sleep evaluation questionnaire. A total of 25 subjects were included in this study, 13 with golimumab and 12 with placebo. At Week 14, 6(46.2%) subjects achieved ASAS20 in golimumab group and 2(16.7%) in placebo group. Significant improvements of other efficacy endpoints were also found in golimumab group. Golimumab was safe and well to lerated. Most of the adverse events were slightly impaired liver function, where as elevated aspartate aminotransferase and/or alanine aminotransferase returned to normal without drug with drawal. Golimumab improves AS activity, clinical symptoms and sleep disturbance in patients with active AS with good safety and tolerability.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/uso terapêutico
Antirreumáticos/uso terapêutico
Espondilite Anquilosante/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Anticorpos Monoclonais/administração & dosagem
Anticorpos Monoclonais/efeitos adversos
Antirreumáticos/administração & dosagem
Antirreumáticos/efeitos adversos
Método Duplo-Cego
Feminino
Seres Humanos
Injeções Subcutâneas
Masculino
Sono/fisiologia
Transtornos do Sono-Vigília
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Antirheumatic Agents); 91X1KLU43E (golimumab)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1426.2017.12.009


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[PMID]:29240803
[Au] Autor:Wang D; Hou Z; Gong Y; Chen S; Lin L; Xiao Z
[Ad] Endereço:Department of Rheumatology, the first Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China.
[Ti] Título:Bone edema on magnetic resonance imaging is highly associated with low bone mineral density in patients with ankylosing spondylitis.
[So] Source:PLoS One;12(12):e0189569, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study aimed to assess the relationship between bone marrow edema (BME) on magnetic resonance imaging (MRI) and bone mineral density (BMD) in patients with ankylosing spondylitis (AS). METHODS: The study included 333 patients with AS who underwent BMD measurements and axial MRI. Additionally, 106 normal controls were included. The modified New York criteria were used as the classification criteria of AS. Clinical, laboratory, and imaging data were collected and analyzed. Lumbar spine and proximal femur BMD were assessed using dual-energy X-ray absorptiometry. Low BMD was defined by a Z-score ≤-2. The Spondyloarthritis Research Consortium of Canada (SPARCC) MRI index was used to assess inflammation at the sacroiliac joint (SIJ) and spine. RESULTS: Among the 333 patients, the male:female ratio was 4.6:1, mean patient age was 28.5±10.6 years, and mean disease duration was 7.3±6.8 years. The prevalences of low BMD, osteopenia, and osteoporosis were significantly higher among AS patients than among controls (19.8%, 62.8%, and 5.7% vs. 4.7%, 33.0%, and 0%, respectively, P = 0.000). The BMD values were significantly lower and prevalences of low BMD at both the spine and femur were significantly higher among patients with BME on MRI than among those without BME. Multivariate logistic regression analysis showed that male sex (OR 3.87, 95% CI 1.21-7.36, P = 0.023), high ASDAS-CRP score (OR 2.83, 95% CI 1.36-4.76, P = 0.015), the presence of BME on sacroiliac MRI (OR 2.83, 95% CI 1.77-6.23, P = 0.000) and spinal MRI (OR 4.06, 95% CI 1.96-8.46, P = 0.000), and high grade of sacroiliitis (OR 2.93, 95% CI 1.82-4.45, P = 0.002) were risk factors for low BMD (any site). The SPARCC scores of the SIJ were negatively correlated with femoral BMD (r = -0.22, 95% CI -0.33 to -0.10, P = 0.000). Additionally, the SPARCC scores of the spine were negatively correlated with BMD values (r = -0.23, 95% CI -0.36 to -0.09, P = 0.003) and Z-scores (r = -0.24, 95% CI -0.36 to -0.12, P = 0.001) at the spine. CONCLUSION: Low BMD is common in AS patients. BME on MRI is highly associated with low BMD at both the spine and femur.
[Mh] Termos MeSH primário: Densidade Óssea
Doenças da Medula Óssea/complicações
Edema/complicações
Imagem por Ressonância Magnética/métodos
Espondilite Anquilosante/diagnóstico por imagem
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adolescente
Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Fatores de Risco
Coluna Vertebral/diagnóstico por imagem
Espondilite Anquilosante/complicações
Espondilite Anquilosante/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189569


  8 / 12166 MEDLINE  
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[PMID]:29095296
[Au] Autor:Zhu R; Song W; Hu W; Jiang Z; Yuan J; Cui Z; Wan J; Liu Y; Feng S; Zhang X
[Ad] Endereço:aDepartment of Spine Surgery, Tianjin Union Medicine Centre bDepartment of Orthopedics, Tianjin Medical University General Hospital, Tianjin, PR China.
[Ti] Título:The treatment strategies for spine fractures in patients with ankylosing spondylitis: A case report.
[So] Source:Medicine (Baltimore);96(44):e8462, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The aim of the study was to explore surgical strategies for effectively treating spine fractures in patients with ankylosing spondylitis (AS) and investigate the postoperative outcomes. METHODS: We retrospectively analyzed 9 patients with AS that was complicated by spine fractures, who underwent surgery at our spine and spinal cord clinic between 2005 and 2012. The surgical methods included posterior instrumentation and bone grafting, with or without decompression. Fracture healing and neurological function recovery were observed postoperatively. The average follow-up period was 45.1 months (range: 24-60). RESULTS: The 9 patients included 7 men and 2 women. Eight patients were treated with long posterior fixation. One patient underwent combined long posterior fixation and anterior bone grafting. The neurological function of these patients improved significantly to varying degrees after surgery, and fracture union and segmental instability of the lumbar vertebrae were radiologically confirmed at the 1-month and 2-year follow-up intervals. Severe surgery-related complications were not observed. CONCLUSIONS: Posterior instrumentation with bone grafting was a satisfying method for treating spine fractures in patients with AS.
[Mh] Termos MeSH primário: Transplante Ósseo/métodos
Fixação de Fratura/métodos
Vértebras Lombares/cirurgia
Fraturas da Coluna Vertebral/cirurgia
Espondilite Anquilosante/complicações
[Mh] Termos MeSH secundário: Adulto
Terapia Combinada
Descompressão Cirúrgica/métodos
Feminino
Seres Humanos
Vértebras Lombares/lesões
Masculino
Meia-Idade
Estudos Retrospectivos
Fraturas da Coluna Vertebral/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008462


  9 / 12166 MEDLINE  
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[PMID]:29068987
[Au] Autor:Chen R; Li F; Xie Q; Xue J; Lai L; Liu S; Zhang L; Hao C
[Ad] Endereço:aDivision of Nephrology, Huashan Hospital bDepartment of Pathology, Shanghai Medical College, Fudan University, Shanghai, China.
[Ti] Título:Membranous nephropathy in a patient with ankylosing spondylitis: A case report.
[So] Source:Medicine (Baltimore);96(43):e8201, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis in this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case of coexistence of AS and MN, to provide the exact relationship of these 2 entities and recognized some causes of renal involvement in AS. PATIENT CONCERNS: A 44-year-old female presented with pain of the left leg for 4 years and pedal edema for 2 weeks. DIAGNOSES: AS was diagnosed according to the patient's clinical manifestation and sacroiliitis observed on computed tomography (CT) scan. Nephrotic syndrome was found and MN was diagnosed according to kidney biopsy in which thickened capillary loops were observed with light microscopy, granular deposits of IgG along the capillary wall were observed using immunofluorescence staining, and subepithelial electron-dense deposits were observed with electron microscopy. No other secondary causes of MN were found on extensive investigations. INTERVENTION: Given the diagnoses, the patient received nonimmunosuppressive therapy for MN and adalimumab for AS. OUTCOMES: The patient got pain relief, as well as urinary protein reduction. LESSONS: This case suggested a secondary MN in association with AS and the relationship between these 2 diseases needed more concern and further illumination.
[Mh] Termos MeSH primário: Glomerulonefrite Membranosa/complicações
Espondilite Anquilosante/complicações
[Mh] Termos MeSH secundário: Adalimumab/uso terapêutico
Adulto
Celecoxib/uso terapêutico
Inibidores de Ciclo-Oxigenase 2/uso terapêutico
Feminino
Glomerulonefrite Membranosa/tratamento farmacológico
Glomerulonefrite Membranosa/etiologia
Glomerulonefrite Membranosa/patologia
Seres Humanos
Espondilite Anquilosante/tratamento farmacológico
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclooxygenase 2 Inhibitors); 0 (Tumor Necrosis Factor-alpha); FYS6T7F842 (Adalimumab); JCX84Q7J1L (Celecoxib)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008201


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[PMID]:29049176
[Au] Autor:Xu H; Qu Y
[Ad] Endereço:Department of Orthopedics, The Yongchuan Hospital of Chongqing Medical University, Chongqing, P.R. China.
[Ti] Título:Correlation of PON1 polymorphisms with ankylosing spondylitis susceptibility: A case-control study in Chinese Han population.
[So] Source:Medicine (Baltimore);96(42):e7416, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Paraoxonase 1 (PON1) modulates the oxidative stress and inflammatory response, thus, it might relate to the risk of ankylosing spondylitis (AS). The aim of present study was to discover the correlation of PON1 polymorphisms (rs662 and rs854560) with PON1 activity and AS risk.Around 128 AS patients and 146 healthy controls were recruited in this case-control study. PON1 polymorphisms were genotyped by direct sequencing. Serum PON1 activity was detected and compared by nonparametric test in different genotypes of PON1 polymorphisms. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to present the relative risk for AS.GG genotype and G allele of rs662 polymorphism were closely correlated with enhanced AS risk (P = .034, OR = 2.318, 95%CI = 1.051-5.113; P = .032, OR = 1.485, 95%CI = 1.033-2.135). PON1 activity was obviously higher in controls than that in AS patients. Significant difference of PON1 activity has been discovered in the different rs662 genotypes (P < .01). rs662 GG genotype carriers had the lowest PON1 activity, followed by AG carriers and the AA carriers. Besides, no significant relationship existed between rs854560 genotypes and AS risk.PON1 rs662 polymorphism is significantly correlated with increased AS risk via inhibiting PON1 activity.
[Mh] Termos MeSH primário: Arildialquilfosfatase/sangue
Grupo com Ancestrais do Continente Asiático/genética
Predisposição Genética para Doença/genética
Polimorfismo de Nucleotídeo Único
Espondilite Anquilosante/genética
[Mh] Termos MeSH secundário: Alelos
Arildialquilfosfatase/genética
Estudos de Casos e Controles
China/etnologia
Feminino
Genótipo
Seres Humanos
Masculino
Razão de Chances
Risco
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.1.8.1 (Aryldialkylphosphatase); EC 3.1.8.1 (PON1 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007416



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