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[PMID]:28745972
[Au] Autor:Ogura T; Mosier BA; Bryant T; Minas T
[Ad] Endereço:Cartilage Repair Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:A 20-Year Follow-up After First-Generation Autologous Chondrocyte Implantation.
[So] Source:Am J Sports Med;45(12):2751-2761, 2017 Oct.
[Is] ISSN:1552-3365
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Treating articular cartilage defects is a demanding problem. Although several studies have reported durable and improved clinical outcomes after autologous chondrocyte implantation (ACI) over a long-term period, there is no report with over 20 years' follow-up. PURPOSE: To evaluate clinical outcomes after first-generation ACI for the treatment of knees with disabling, large single and multiple cartilage defects for which patients wished to avoid prosthetic arthroplasty, with a minimum of 20 years' follow-up. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: The authors reviewed prospectively collected data from 23 patients (24 knees; mean age, 35.4 years [range, 13-52 years]) undergoing ACI for the treatment of symptomatic, full-thickness articular cartilage lesions. A mean of 2.1 lesions per knee were treated over a mean total surface area of 11.8 cm (range, 2.4-30.5 cm ) per knee. Kaplan-Meier survival analysis and functional outcome scores, including the modified Cincinnati Knee Rating System, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Short Form-36 (SF-36), were used. Patients also self-reported an improvement in pain with a visual analog scale and a satisfaction survey. RESULTS: The 20-year survival rate was 63% (95% CI, 40%-78%). The evaluation of the 15 knees with retained grafts demonstrated that all clinical scores except the WOMAC subscore for stiffness and SF-36 mental component summary score improved significantly and were sustained to 20 years postoperatively. Ninety-three percent of these patients rated knee-specific outcomes as good or excellent. The outcomes for 9 of 24 knees were considered failures, including 5 undergoing revision ACI and 4 being converted to arthroplasty at a mean of 1.7 and 5.9 years, respectively. Only 1 of 5 knees that underwent revision ACI was converted to arthroplasty at 1.9 years after the index surgery, and the other 4 patients were able to maintain their biological knee. Overall, 20 years later, 79% of patients maintained their native knee, for which they initially sought treatment, and were satisfied when evaluated. CONCLUSION: First-generation ACI provided satisfactory survival rates and significant clinical improvements over a 20-year follow-up, which offers an important standard for comparison with newer-generation ACI technologies of the future.
[Mh] Termos MeSH primário: Doenças das Cartilagens/cirurgia
Cartilagem Articular/cirurgia
Condrócitos/transplante
[Mh] Termos MeSH secundário: Adolescente
Adulto
Cartilagem Articular/lesões
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
Inquéritos e Questionários
Transplante Autólogo
Resultado do Tratamento
Escala Visual Analógica
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1177/0363546517716631


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[PMID]:28976425
[Au] Autor:Wang D; Jones KJ; Eliasberg CD; Pais MD; Rodeo SA; Williams RJ
[Ad] Endereço:1Sports Medicine and Shoulder Service, Hospital for Special Surgery, New York, NY 2Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California.
[Ti] Título:Condyle-Specific Matching Does Not Improve Midterm Clinical Outcomes of Osteochondral Allograft Transplantation in the Knee.
[So] Source:J Bone Joint Surg Am;99(19):1614-1620, 2017 Oct 04.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Condyle-specific matching for osteochondral allograft transplantation (OCA) pairs donor and recipient condyles in an attempt to minimize articular incongruity. While the majority of cartilage defects are located on the medial femoral condyle, lateral femoral condyles are more commonly available as a graft source. The purpose of this study was to compare the clinical outcomes of patients treated with non-orthotopic (lateral-to-medial condyle or medial-to-lateral condyle) OCA with those treated with traditional orthotopic (medial-to-medial condyle or lateral-to-lateral condyle) OCA. We hypothesized that clinical outcomes would be similar between groups at midterm follow-up. METHODS: A retrospective review of prospectively collected data on patients treated with OCA from 2000 to 2014 was conducted. Seventy-seven patients with a full-thickness cartilage defect of a femoral condyle were treated with either orthotopic (n = 50) or non-orthotopic (n = 27) OCA. A minimum follow-up of 2 years was required for analysis. Patients in each group were matched according to sex, age, and total chondral defect size. Reoperations and patient responses to validated outcome measures were reviewed. Failure was defined as any revision cartilage procedure or conversion to knee arthroplasty. RESULTS: The mean duration of follow-up was 4.0 years (range, 2 to 16 years). The orthotopic and non-orthotopic OCA groups were comparable in terms of demographics, the mean number of prior ipsilateral knee operations, and the percentage of concomitant procedures at baseline. Reoperation (p = 0.427) and failure (p = 0.917) rates did not differ significantly between groups. Both groups demonstrated significant increases in the Short Form-36 (SF-36) physical functioning and pain, International Knee Documentation Committee (IKDC), and Knee Outcome Survey-Activities of Daily Living (KOS-ADL) scores compared with baseline (p < 0.004). Outcome scores (baseline and postoperative) and change scores did not differ significantly between groups. CONCLUSIONS: Clinical outcomes do not differ between patients treated with orthotopic OCA and those treated with non-orthotopic OCA, suggesting that condyle-specific matching may not be necessary. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
[Mh] Termos MeSH primário: Artroplastia do Joelho
Doenças das Cartilagens/cirurgia
Cartilagem Articular/cirurgia
Articulação do Joelho/patologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Reoperação
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.16.01542


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[PMID]:28784693
[Au] Autor:Mari L; Behr S; Shea A; Dominguez E; Johnson PJ; Ekiri A; De Risio L
[Ad] Endereço:Department of Neurology/Neurosurgery, Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk, UK.
[Ti] Título:Outcome comparison in dogs with a presumptive diagnosis of thoracolumbar fibrocartilaginous embolic myelopathy and acute non-compressive nucleus pulposus extrusion.
[So] Source:Vet Rec;181(11):293, 2017 Sep 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dogs with fibrocartilaginous embolic myelopathy (FCEM) or acute non-compressive nucleus pulposus extrusion (ANNPE) are reported to have a fair prognosis; however, persistent motor/autonomic deficits are possible. Specific MRI patterns have been suggested to differentiate these diseases although never been validated with histopathology in large studies. The aim of this retrospective study was to evaluate if these MRI patterns are associated with different clinical outcomes in dogs with peracute non-progressive T3-L3 myelopathy. Two hundred and one dogs were included. Outcome data were obtained via medical records and telephone questionnaires. MRIs were blindly reviewed by three board-certified observers, obtaining substantial to almost perfect interobserver agreement on diagnoses (κ=0.635-0.828). Presumptive ANNPE and FCEM were diagnosed in 157 and 44 dogs , respectively. Ambulatory function was regained in 99 per cent of cases, with persistent motor deficits in 83.6 per cent and 92.5 per cent of dogs with presumptive ANNPE and FCEM, respectively. The presumptive diagnosis was not associated with motor function recovery, recovery times or urinary continence. Faecal incontinence was five times more likely in dogs with presumptive ANNPE (23 per cent) compared with presumptive FCEM (7.5 per cent).Distinguishing between MRI patterns of presumptive ANNPE or FCEM in dogs with peracute non-progressive T3-L3 myelopathy may help predict the risk of developing faecal incontinence.
[Mh] Termos MeSH primário: Doenças das Cartilagens/veterinária
Doenças do Cão/diagnóstico
Embolia/veterinária
Degeneração do Disco Intervertebral/veterinária
Imagem por Ressonância Magnética/veterinária
Núcleo Pulposo/patologia
Doenças da Medula Espinal/veterinária
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Doenças das Cartilagens/diagnóstico
Diagnóstico Diferencial
Cães
Embolia/diagnóstico
Degeneração do Disco Intervertebral/diagnóstico
Vértebras Lombares
Prognóstico
Reprodutibilidade dos Testes
Estudos Retrospectivos
Doenças da Medula Espinal/diagnóstico
Vértebras Torácicas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170809
[St] Status:MEDLINE
[do] DOI:10.1136/vr.104090


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[PMID]:28647370
[Au] Autor:Kang X; Yang Z; Sheng J; Liu JB; Xie QY; Zheng W; Chen K
[Ad] Endereço:Department of Orthopedics, Chengdu Military General Hospital, 270 Rongdu Avenue, Jinniu District, Chengdu, Sichuan 610083, China. Electronic address: kxpaper@sina.com.
[Ti] Título:Oleanolic acid prevents cartilage degeneration in diabetic mice via PPARγ associated mitochondrial stabilization.
[So] Source:Biochem Biophys Res Commun;490(3):834-840, 2017 Aug 26.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hyperglycemia-induced cartilage degeneration induces osteoarthritis (OA). Since oleanolic acid (OLA) have several pharmacological effects such as anti-inflammatory, anti-oxidant, we hypothesized it possesses protection against high glucose injured cartilage. We now report that OLA decreased type X collagen and reversed the cartilage degeneration in growth plate from db/db mice. OLA increased type â…¡ collagen expression in a concentration-dependent manner (10-50 µΜ) in high glucose-treated chondrocytes. OLA prevented the high glucose induced cell injury and decreased the level of MMP-13, PGE2 and IL-6 due to decreasing mitochondrial membrane potential and stimulated the ATP production. Moreover, OLA treatment inhibited apoptosis. And the reversed SOD2 expression and activity may be ascribed to decreased SOD2 protein degradation by OLA treatment, via PPPAγ. In conclusion, OLA protected against the high-glucose-induced cartilage injury via PPARγ/SOD2 pathway.
[Mh] Termos MeSH primário: Doenças das Cartilagens/prevenção & controle
Complicações do Diabetes/prevenção & controle
Diabetes Mellitus Experimental/complicações
Hiperglicemia/complicações
Ácido Oleanólico/uso terapêutico
PPAR gama/metabolismo
Substâncias Protetoras/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Cartilagem/efeitos dos fármacos
Cartilagem/metabolismo
Cartilagem/patologia
Doenças das Cartilagens/etiologia
Doenças das Cartilagens/metabolismo
Doenças das Cartilagens/patologia
Células Cultivadas
Complicações do Diabetes/etiologia
Complicações do Diabetes/metabolismo
Complicações do Diabetes/patologia
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/patologia
Hiperglicemia/metabolismo
Hiperglicemia/patologia
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos Endogâmicos C57BL
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Mitocôndrias/patologia
Ácido Oleanólico/farmacologia
Substâncias Protetoras/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PPAR gamma); 0 (Protective Agents); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170626
[St] Status:MEDLINE


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[PMID]:28632586
[Au] Autor:Flanigan DC; Carey JL; Brophy RH; Graham WC; DiBartola AC; Hamilton D; Nagaraja HN; Lattermann C
[Ad] Endereço:1Division of Sports Medicine Cartilage Repair Center, Department of Orthopaedics (D.C.F., W.C.G., and A.C.D.), Division of Biostatistics, College of Public Health (H.N.N.), and Wexner Medical Center (D.C.F. and A.C.D.), The Ohio State University, Columbus, Ohio 2Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 3Department of Orthopaedic Surgery, Washington University, St. Louis, Missouri 4OrthoCarolina, Pineville, North Carolina 5University of Kentucky, Lexington, Kentucky.
[Ti] Título:Interrater and Intrarater Reliability of Arthroscopic Measurements of Articular Cartilage Defects in the Knee.
[So] Source:J Bone Joint Surg Am;99(12):979-988, 2017 Jun 21.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cartilage lesions of the knee are difficult to treat. Lesion size is a critical factor in treatment algorithms, and the accurate, reproducible sizing of lesions is important. In this study, we evaluated the interrater and intrarater reliability of, and correlations in relation to, various arthroscopic sizing techniques. METHODS: Five lesions were created in each of 10 cadaveric knees (International Cartilage Repair Society grade 3C). Three orthopaedic surgeons used 4 techniques (visualization and use of a 3-mm probe, a simple metal ruler, and a sliding metallic ruler tool) to estimate lesion size. Repeated-measures data were analyzed using a mixed-effect linear model. The differences between observed and gold-standard (plastic mold) values were used as the response. Intraclass and interclass correlation coefficient (ICC) values for intrarater and interrater reliability were computed, as were overall correlation coefficients between measurements and gold standards. RESULTS: The mean lesion size was 2.37 cm (range, 0.36 to 6.02 cm). Rater, lesion location and size, and measurement method all affected the cartilage defect measurements. Surgeons underestimated lesion size, and measurements of larger lesions had a higher percentage of error compared with those of smaller lesions. When compared with plastic molds of lesions, 60.5% of surgeon measurements underestimated lesion size. Overall, the correlation between measurements and gold standards was strongest for the simple metal ruler method and weakest for the visualization method. CONCLUSIONS: Several factors may influence arthroscopic estimation of cartilage lesion size: the lesion location, measurement tool, surgeon, and defect size itself. The intrarater and interrater reliability was moderate to good using a 3-mm probe, sliding metallic ruler tool, or simple metal ruler and was fair to moderate using visualization only. CLINICAL RELEVANCE: There is a need for more accurate methods of determining the size of articular cartilage lesions.
[Mh] Termos MeSH primário: Doenças das Cartilagens/patologia
Cartilagem Articular/patologia
[Mh] Termos MeSH secundário: Artroscopia/métodos
Cadáver
Competência Clínica/normas
Seres Humanos
Articulação do Joelho
Variações Dependentes do Observador
Cirugiões Ortopédicos/normas
Medicina Esportiva/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.16.01132


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[PMID]:28577777
[Au] Autor:Zeineddine HA; Frush TJ; Saleh ZM; El-Othmani MM; Saleh KJ
[Ad] Endereço:Department of Surgery, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
[Ti] Título:Applications of Tissue Engineering in Joint Arthroplasty: Current Concepts Update.
[So] Source:Orthop Clin North Am;48(3):275-288, 2017 Jul.
[Is] ISSN:1558-1373
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Research in tissue engineering has undoubtedly achieved significant milestones in recent years. Although it is being applied in several disciplines, tissue engineering's application is particularly advanced in orthopedic surgery and in degenerative joint diseases. The literature is full of remarkable findings and trials using tissue engineering in articular cartilage disease. With the vast and expanding knowledge, and with the variety of techniques available at hand, the authors aimed to review the current concepts and advances in the use of cell sources in articular cartilage tissue engineering.
[Mh] Termos MeSH primário: Artroplastia
Doenças das Cartilagens/cirurgia
Engenharia Tecidual
[Mh] Termos MeSH secundário: Artroplastia/instrumentação
Artroplastia/métodos
Artroplastia/tendências
Seres Humanos
Ortopedia/tendências
Engenharia Tecidual/métodos
Engenharia Tecidual/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28577776
[Au] Autor:Frank RM; Della Valle CJ; Plummer DR; Chalmers PN; Cole BJ
[Ad] Endereço:Department of Orthopaedic Surgery, Rush University Medical Center, 1611 West Harrison, Suite 300, Chicago, IL 60612, USA. Electronic address: rmfrank3@gmail.com.
[Ti] Título:Does Prior Cartilage Restoration Impact Outcomes Following Knee Arthroplasty?
[So] Source:Orthop Clin North Am;48(3):265-273, 2017 Jul.
[Is] ISSN:1558-1373
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study compared patients who failed a cartilage restoration procedure and underwent ipsilateral knee arthroplasty with matched control subjects undergoing knee arthroplasty without prior cartilage restoration. Although patients with a failed cartilage procedure derived benefit from knee arthroplasty, their magnitude of improvement and final outcomes scores were lower than the matched control subjects. In this cohort, the cartilage patients also experienced little to no benefit from cartilage restoration, suggesting that unmeasured shared patient characteristics may play a role. This information can be used to counsel this difficult patient population on expected outcomes following arthroplasty procedures. Further research identifying characteristics of responders to treatment remains critical to refine clinical decision-making for this difficult patient group.
[Mh] Termos MeSH primário: Artroplastia do Joelho
Doenças das Cartilagens
Cartilagem Articular
Osteoartrite do Joelho
Dor Pós-Operatória
[Mh] Termos MeSH secundário: Adulto
Artroplastia do Joelho/efeitos adversos
Artroplastia do Joelho/métodos
Doenças das Cartilagens/diagnóstico
Doenças das Cartilagens/etiologia
Doenças das Cartilagens/fisiopatologia
Doenças das Cartilagens/prevenção & controle
Cartilagem Articular/lesões
Cartilagem Articular/fisiopatologia
Cartilagem Articular/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteoartrite do Joelho/patologia
Osteoartrite do Joelho/fisiopatologia
Osteoartrite do Joelho/cirurgia
Dor Pós-Operatória/diagnóstico
Dor Pós-Operatória/etiologia
Dor Pós-Operatória/fisiopatologia
Dor Pós-Operatória/prevenção & controle
Reoperação/efeitos adversos
Reoperação/métodos
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28577712
[Au] Autor:Saltzman BM; Leroux T; Cole BJ
[Ad] Endereço:Department of Orthopedic Surgery, Rush University Medical Center, 1611 West Harrison Street, Suite 300, Chicago, IL 60612, USA.
[Ti] Título:Management and Surgical Options for Articular Defects in the Shoulder.
[So] Source:Clin Sports Med;36(3):549-572, 2017 Jul.
[Is] ISSN:1556-228X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Isolated, full-thickness chondral lesions of the glenohumeral joint are a significant pathology encountered by laborers, athletes, and the elderly. A thorough history should be obtained in any patient presenting to the office with shoulder pain and concern for the etiology being an articular cartilage defect. The first-line imaging should include plain radiographs of the glenohumeral joint; MRI and CT can be ordered as necessary to provide greater detail. Typically, the initial treatment of glenohumeral chondral disease is nonsurgical; however, many surgical treatment options have been refined to provide pain relief, create reparative tissue, or restore the articular surface.
[Mh] Termos MeSH primário: Doenças das Cartilagens/terapia
Cartilagem Articular/lesões
Cartilagem Articular/cirurgia
Lesões do Ombro/terapia
Ombro/cirurgia
[Mh] Termos MeSH secundário: Artroplastia
Artroscopia
Doenças das Cartilagens/diagnóstico
Doenças das Cartilagens/cirurgia
Condrócitos/transplante
Seres Humanos
Plasma Rico em Plaquetas
Ombro/anatomia & histologia
Lesões do Ombro/diagnóstico
Lesões do Ombro/cirurgia
Transplante Autólogo
Transplante Homólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28577713
[Au] Autor:Makhni EC; Stone AV; Ukwuani GC; Zuke W; Garabekyan T; Mei-Dan O; Nho SJ
[Ad] Endereço:Division of Sports Medicine, Department of Orthopedic Surgery, Henry Ford Health System, 6777 West Maple Road, 3rd Floor East, West Bloomfield, MI 48322, USA.
[Ti] Título:A Critical Review: Management and Surgical Options for Articular Defects in the Hip.
[So] Source:Clin Sports Med;36(3):573-586, 2017 Jul.
[Is] ISSN:1556-228X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients with articular cartilage lesions of the hip may present with pain and symptoms that may be vague in nature and onset. Therefore, a thorough history and physical examination should be performed for every patient presenting with hip pain and/or disability. The management may be operative or nonoperative. Nonoperative management includes a trial of rest and/or activity modification, along with anti-inflammatory medications, physical therapy, and biologic injections. Operative treatment in the form of arthroscopic techniques continues to decrease morbidity and offer innovative solutions and new applications for microfracture, ACT, and AMIC.
[Mh] Termos MeSH primário: Doenças das Cartilagens/terapia
Cartilagem Articular/lesões
Cartilagem Articular/cirurgia
Lesões do Quadril/terapia
Quadril/cirurgia
[Mh] Termos MeSH secundário: Artroplastia/métodos
Artroscopia/métodos
Doenças das Cartilagens/diagnóstico
Condrócitos/transplante
Lesões do Quadril/diagnóstico
Lesões do Quadril/cirurgia
Seres Humanos
Transplante Autólogo
Viscossuplementos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Viscosupplements)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28577711
[Au] Autor:Hinckel BB; Gomoll AH
[Ad] Endereço:Missouri Orthopaedic Institute, University of Missouri, Virginia Avenue, Columbia, MO, USA.
[Ti] Título:Autologous Chondrocytes and Next-Generation Matrix-Based Autologous Chondrocyte Implantation.
[So] Source:Clin Sports Med;36(3):525-548, 2017 Jul.
[Is] ISSN:1556-228X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Focal chondral defects of the knee are common and can significantly impair quality of life. The autologous chondrocyte implantation technique has evolved over the past 20 years; the newest third-generation technique is matrix-induced autologous chondrocyte implantation. Physical examination is important to characterize location and source of pain and identify associated injuries. Imaging studies allow characterization of the lesions, identification of associated lesions, and alignment. Conservative measures should be exhausted before proceeding with surgical treatment. Steps of surgical treatment are diagnostic arthroscopy and biopsy, chondrocyte culture, and chondrocyte implantation. The techniques and their outcomes are discussed in this article.
[Mh] Termos MeSH primário: Doenças das Cartilagens/cirurgia
Cartilagem Articular/lesões
Cartilagem Articular/cirurgia
Condrócitos/transplante
Traumatismos do Joelho/cirurgia
[Mh] Termos MeSH secundário: Doenças das Cartilagens/diagnóstico
Cartilagem Articular/diagnóstico por imagem
Seres Humanos
Traumatismos do Joelho/diagnóstico
Transplante Autólogo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE



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