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[PMID]: 28460477 [Au] Autor: Park E; Kim D; Lee SM; Jun HS [Ad] Endereço: Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea. [Ti] Título: Inhibition of lysophosphatidic acid receptor ameliorates Sjögren's syndrome in NOD mice. [So] Source: Oncotarget;8(16):27240-27251, 2017 Apr 18. [Is] ISSN: 1949-2553 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Lysophosphatidic acid (LPA), a bioactive lysophospholipid, is involved in the pathogenesis of chronic inflammatory and autoimmune diseases. In this study, we investigated the role of LPA/LPA receptor (LPAR) signaling in the pathogenesis of Sjögren's syndrome (SS). We found that autotaxin, an LPA producing enzyme, and LPAR1 and LPAR3 mRNA, and IL-17 mRNA were highly expressed in the exocrine glands of 20-week-old nonobese diabetic (NOD) mice, which show SS symptoms at this age, as compared with non-symptomatic 8-week-old NOD mice. In an adoptive transfer model using NOD lymphocytes, treatment with Ki16425, an LPAR1/3 antagonist, restored tear and saliva secretion and decreased symptoms of SS compared with the vehicle-treated group. IL-17 levels in serum and lacrimal glands were also significantly reduced by Ki16425 in recipient mice. In addition, Ki16425 treatment of 20-week-old NOD mice, which spontaneously developed SS, restored saliva volume. Treatment of NOD splenocytes with LPA induced the expression of IL-17 in a dose-dependent manner, and Ki16425 inhibited this increase. LPA stimulated the activation of ROCK2 and p38 MAPK; and inhibition of ROCK2 or p38 MAPK suppressed LPA-induced IL-17 expression. Our data suggest that LPAR signaling stimulates SS development by induction of IL-17 production via ROCK and p38 MAPK pathways. Thus, LPAR inhibition could be a possible therapeutic strategy for SS. [Mh] Termos MeSH primário: Receptores de Ácidos Lisofosfatídicos/antagonistas & inibidores Receptores de Ácidos Lisofosfatídicos/metabolismo Síndrome de Sjogren/metabolismo [Mh] Termos MeSH secundário: Animais Autoanticorpos/sangue Autoanticorpos/imunologia Citocinas/genética Citocinas/metabolismo Modelos Animais de Doenças Feminino Expressão Gênica Imunoterapia Adotiva Mediadores da Inflamação/metabolismo Interleucina-17/sangue Interleucina-17/metabolismo Isoxazóis/farmacologia Aparelho Lacrimal/imunologia Aparelho Lacrimal/metabolismo Aparelho Lacrimal/patologia Masculino Camundongos Camundongos Endogâmicos NOD Diester Fosfórico Hidrolases/genética Diester Fosfórico Hidrolases/metabolismo Propionatos/farmacologia Receptores de Ácidos Lisofosfatídicos/genética Saliva/metabolismo Transdução de Sinais/efeitos dos fármacos Síndrome de Sjogren/genética Síndrome de Sjogren/imunologia Síndrome de Sjogren/terapia Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo Quinases Associadas a rho/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid); 0 (Autoantibodies); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Interleukin-17); 0 (Isoxazoles); 0 (Propionates); 0 (Receptors, Lysophosphatidic Acid); EC 2.7.11.1 (Rock2 protein, mouse); EC 2.7.11.1 (rho-Associated Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.1.4.- (Phosphoric Diester Hydrolases); EC 3.1.4.39 (alkylglycerophosphoethanolamine phosphodiesterase) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170503 [St] Status: MEDLINE [do] DOI: 10.18632/oncotarget.15916

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[PMID]: 29465536 [Au] Autor: Yan X; Jin J [Ad] Endereço: Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China. [Ti] Título: Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and Sjögren syndrome: A case report. [So] Source: Medicine (Baltimore);97(8):e0004, 2018 Feb. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Primary cutaneous amyloidosis (PCA) is a localized skin disorder characterized by the abnormal deposition of amyloid in the extracellular matrix of the dermis. The association between PCA and other diseases, although rare, has been documented for various autoimmune diseases. PCA associated with autoimmune hepatitis-primary biliary cirrhosis (AIH-PBC) overlap syndrome and Sjögren syndrome (SS) has not been previously reported in the literature. PATIENT CONCERNS: A 50-year-old woman presented with progressive abnormal liver enzyme levels and was referred to our department. DIAGNOSES: Due to the patient's symptoms, laboratory test results, radiographic findings, and pathologic results, she was diagnosed with PCA associated with AIH-PBC overlap syndrome and SS. INTERVENTIONS: She was subsequently treated with a combination of ursodeoxycholic acid (UDCA), prednisone, and azathioprine. OUTCOMES: While this treatment can achieve therapeutic success, it cannot prevent complications from cirrhosis. This patient remains alive but experienced an emergent gastrointestinal hemorrhage. LESSONS: While we acknowledge that this is a single case, these findings extend our knowledge of immunological diseases associated with PCA and suggest a common, immune-mediated pathogenic pathway between PCA, AIH-PBC overlap syndrome, and SS. After 12 years of follow up, clinical manifestations have developed, and these autoimmune diseases have progressed. The combination of UDCA, prednisone, and azathioprine can achieve therapeutic success but cannot prevent disease progression. Routine follow up for this patient is necessary to document disease progression. [Mh] Termos MeSH primário: Amiloidose Familiar/imunologia Hepatite Autoimune/complicações Cirrose Hepática Biliar/complicações Síndrome de Sjogren/complicações Dermatopatias Genéticas/imunologia Doenças do Tecido Conjuntivo Indiferenciado/complicações [Mh] Termos MeSH secundário: Amiloidose Familiar/tratamento farmacológico Anti-Inflamatórios/administração & dosagem Azatioprina/administração & dosagem Colagogos e Coleréticos/administração & dosagem Quimioterapia Combinada Feminino Hepatite Autoimune/tratamento farmacológico Hepatite Autoimune/imunologia Seres Humanos Imunossupressores/administração & dosagem Cirrose Hepática Biliar/tratamento farmacológico Cirrose Hepática Biliar/imunologia Meia-Idade Prednisona/administração & dosagem Síndrome de Sjogren/tratamento farmacológico Síndrome de Sjogren/imunologia Dermatopatias Genéticas/tratamento farmacológico Resultado do Tratamento Doenças do Tecido Conjuntivo Indiferenciado/tratamento farmacológico Doenças do Tecido Conjuntivo Indiferenciado/imunologia Ácido Ursodesoxicólico/administração & dosagem [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Cholagogues and Choleretics); 0 (Immunosuppressive Agents); 724L30Y2QR (Ursodeoxycholic Acid); MRK240IY2L (Azathioprine); VB0R961HZT (Prednisone) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180302 [Lr] Data última revisão: 180302 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180222 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000010004

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[PMID]: 29231165 [Au] Autor: Cuny C; Vaerst B; Gabrielpillai J; Tahtali A; Balster S; Lissner R; Woodcock BG [Ti] Título: Polyvalent immunoglobulins with vitamin D3 and vitamin B12 in the treatment of Sjogren's syndrome in a vegetarian with stomatitis, glossodynia, xerostomia, and elevated antinuclear antibodies: Case report
. [So] Source: Int J Clin Pharmacol Ther;56(1):24-27, 2018 Jan. [Is] ISSN: 0946-1965 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: BACKGROUND: Sjogren's syndrome, involving sicca symptoms with xerostomia, stomatitis, and considerable pain is a difficult-to-treat autoimmune disease where the treatment options are limited and, as in the case of methotrexate, have a low therapeutic index. CASE REPORT: This case report concerns a male patient, aged 75 years and vegetarian, with Sjogren's syndrome subsequently confirmed by salivary gland biopsy. Serum antinuclear antibodies (ANA) were elevated (1 : 320). Low serum vitamin B12 and iron levels could be improved after 20 days using vitamin B12 and iron oral supplements. Despite symptomatic treatment, xerostomia, glossitis, and glossodynia were still present, at times marked, after 12 months when the ANA titer was unchanged. Following treatment with an anti-inflammatory polyvalent immunoglobulin formulation (Lactobin®N, 7 g daily), a bovine colostrum concentrate given orally in combination with oral vitamin D3 (2,000 IU daily), sicca symptoms and xerostomia progressively decreased and at day 750 were confined to occasional and minor glossitis of the upper lip. CONCLUSION: This case report demonstrates the satisfactory control of Sjogren's syndrome using oral polyvalent immunoglobulins with vitamin D3. In contrast to treatment options involving antimalarial drugs and methotrexate, there are no safety issues in patients tolerant to milk products.
. [Mh] Termos MeSH primário: Colecalciferol/administração & dosagem Imunoglobulinas/uso terapêutico Síndrome de Sjogren/tratamento farmacológico Estomatite/tratamento farmacológico Vitamina B 12/administração & dosagem [Mh] Termos MeSH secundário: Idoso Anticorpos Antinucleares/sangue Seres Humanos Masculino Síndrome de Sjogren/imunologia Estomatite/imunologia Vegetarianos [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antibodies, Antinuclear); 0 (Immunoglobulins); 1C6V77QF41 (Cholecalciferol); P6YC3EG204 (Vitamin B 12) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE [do] DOI: 10.5414/CP203143

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[PMID]: 29390349 [Au] Autor: Fujimoto S; Kawabata H; Kurose N; Kawanami-Iwao H; Sakai T; Kawanami T; Fujita Y; Fukushima T; Masaki Y [Ad] Endereço: Department of Hematology and Immunology, Kanazawa Medical University. [Ti] Título: Sjögren's syndrome manifesting as clinicopathological features of TAFRO syndrome: A case report. [So] Source: Medicine (Baltimore);96(50):e9220, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: TAFRO syndrome is a newly proposed disorder that manifests as thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. In this report, we describe the development of severe TAFRO syndrome-like systemic symptoms during the clinical course of juvenile-onset Sjögren's syndrome in a 32-year-old woman. PATIENT CONCERNS: The patient was admitted due to dyspnea, fever, polyarthralgia, and generalized edema. She had been diagnosed with Sjögren's syndrome at the age of 14 years, based on histopathological examination of a biopsy of the minor salivary glands and the development of Raynaud's phenomenon, with no follow-up treatment required. On admission, she presented with anemia, elevated C-reactive protein levels, anasarca, and hepato-splenomegaly. A bone marrow examination revealed increased megakaryocytes with reticulin fibrosis, and the histopathology of an axillary lymph node was consistent with mixed-type Castleman disease. Eventually, she developed thrombocytopenia. INTERVENTIONS: Her symptoms fulfilled all of the major and minor categories of the diagnostic criteria for TAFRO syndrome. However, considering her prior diagnosis, we assumed that the clinical presentation was consistent with an acute exacerbation of Sjögren's syndrome. Unlike typical cases of TAFRO syndrome, the administration of relatively low-dose prednisolone relieved her symptoms. LESSONS: Differentiation between TAFRO syndrome and exacerbation of an autoimmune disease is clinically important, although this can be challenging. Identification of specific biomarkers for TAFRO syndrome would be clinically beneficial. [Mh] Termos MeSH primário: Doença de Castleman/diagnóstico Síndrome de Sjogren/diagnóstico [Mh] Termos MeSH secundário: Adulto Doença de Castleman/tratamento farmacológico Diagnóstico Diferencial Feminino Glucocorticoides/uso terapêutico Seres Humanos Prednisolona/uso terapêutico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Glucocorticoids); 9PHQ9Y1OLM (Prednisolone) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009220

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[PMID]: 29390343 [Au] Autor: Liu Z; Dong Z; Liang X; Liu J; Xuan L; Wang J; Zhang G; Hao W [Ad] Endereço: Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Science. [Ti] Título: Health-related quality of life and psychological status of women with primary Sjögren's syndrome: A cross-sectional study of 304 Chinese patients. [So] Source: Medicine (Baltimore);96(50):e9208, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Patients with primary Sjögren syndrome (pSS) always suffer from dryness, pain, and fatigue caused by the involvement of multiple different systems or organs. The uncomfortable disease symptoms, the consequent disability, and the side effects of therapeutic drugs decrease the quality of life and lead to emotional problems. We investigated the health-related quality of life and psychological status of a large cohort of women patients with pSS and associated factors.A total of 304 women with pSS referred to Peking Union Medical College Hospital during 2011 and 2014 were included. The internationally recognized Short Form (36) Health Survey (SF-36) was used to assess patients' quality of life; a higher score indicated a better quality of life. Patients' psychological status was assessed by the Hospital Anxiety and Depression Scale (HADS), and higher scores predicted more anxiety or depression.Patients with pSS had remarkably lower SF-36 scores. The Hospital Anxiety Scale (HAS) and Hospital Depression Scale (HDS) scores of the pSS patients (7 [4,10] and 6 [3,10], respectively) were significantly higher than that of patients with other internal diseases (3.37 ± 2.81 and 3.83 ±â€Š3.14; both P < .001). Negative predictors of quality of life were: pain (physical condition, ß = -0.225; P < .001); fatigue (physical condition, ß = -0.298; P < .001; and mental condition, ß = -0.319; P < .001). Risk factors for anxiety were: young age (ß = -0.059; P = .035); pain (ß = 0.025; P = .028); or fatigue (ß = 0.029; P = .004). Risk factors for depression were: xeroderma (ß = 0.030; P = .003); pain (ß = 0.022; P = .047); or fatigue (ß = 0.033; P = .001).Patients with pSS have a low quality of life with anxiety and depression. Pain and fatigue are primary factors for lower quality of life, which cause more anxiety and depression. [Mh] Termos MeSH primário: Qualidade de Vida Síndrome de Sjogren/psicologia [Mh] Termos MeSH secundário: Adulto Ansiedade/psicologia China Estudos Transversais Depressão/psicologia Feminino Seres Humanos Meia-Idade Escalas de Graduação Psiquiátrica [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009208

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[PMID]: 29390329 [Au] Autor: Zhou Z; Jiang W; Wang M; Liu Y; Zhang W; Huang M; Liang D [Ti] Título: Primary Sjögren syndrome that initially presented with repeated hypergammaglobulinemic purpura after prolonged sitting: A case report. [So] Source: Medicine (Baltimore);96(50):e9187, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Purpura is a common dermatologic manifestation in Sjögren syndrome (SS). When a patient presents with sicca symptoms, the diagnosis of SS is not difficult. PATIENT CONCERNS: Here, we reported a case of a 52-year-old Chinese woman who initially presented with nonpalpable purpura on both lower extremities, and these lesions had developed soon after prolonged sitting. In the past 2 years, she had repeated cutaneous nonpalpable purpura 4 times. She had no sicca symptoms, dry eyes, or dry mouth. DIAGNOSES: Combining the laboratory findings, Schirmer test, and labial gland biopsy, primary SS was confirmed. INTERVENTIONS: The patient was placed on a trial of hydroxychloroquine (200 mg once daily). OUTCOMES: The purpura on both lower extremities had faded at the sixth day after onset and at the third day after hydroxychloroquine treatment. LESSONS: These case was not easy to diagnosis primary SS because she had no sicca symptoms. A patient with primary SS who initially presented with recurrent purpura associated with prolonged sitting. Prolonged sitting had been a possible aggravating factor for the cutaneous purpura of this patient with primary SS. [Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico Hidroxicloroquina/uso terapêutico Hipergamaglobulinemia/diagnóstico Hipergamaglobulinemia/tratamento farmacológico Púrpura/diagnóstico Púrpura/tratamento farmacológico Síndrome de Sjogren/diagnóstico Síndrome de Sjogren/tratamento farmacológico [Mh] Termos MeSH secundário: Feminino Seres Humanos Extremidade Inferior Meia-Idade Postura [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antirheumatic Agents); 4QWG6N8QKH (Hydroxychloroquine) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009187

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[PMID]: 29390256 [Au] Autor: Yu W; Qu W; Wang Z; Xin C; Jing R; Shang Y; Zou H; Wang H; Feng S [Ad] Endereço: Hematology Department, Yantai Affiliated Hospital, Binzhou Medical University, Yantai. [Ti] Título: Sjogren's syndrome complicating pancytopenia, cerebral hemorrhage, and damage in nervous system: A case report and literature review. [So] Source: Medicine (Baltimore);96(50):e8542, 2017 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Sjogren's syndrome(SS) is a chronic autoimmune disease, which damages exocrine glands especially salivary and lacrimal glands, with xerostomia and xerophthalmia as common symptoms. PATIENT CONCERNS: We report a case of a 49-year-old woman presented with pancytopenia. Her laboratory examinations lead us diagnose her as Sjogren's syndrome complicating pancytopenia. She had neurological symptoms during her treatment, which represent only 4.5% of Sjogren's syndrome complicating damage in nervous system. DIAGNOSES: Sjogren's syndrome complicating pancytopenia. INTERVENTIONS: Dexamethasone (40mg QD for 4 days) and immunoglobulin (25g QD for 2 days) were administered for intensive treatment followed by oral methylprednisolone 40mg QD as maintenance treatment. Total glucosides of paeony 0.6g TID and danazol 0.2g BID per os were given. We also gave her Piperacillin-tazobactam and moxifloxacin for anti-infection and Fluconazole for anti-fungal therapy, as well as other supportive treatments. OUTCOMES: Follow-up of the patient observed the normalization of peripheral blood cell count, immunity indices and neurological examinations 6 months after discharge. LESSONS: For patients presented with blood system abnormalities unilineage or multiple-lineage cytopenia in particular, history investigations and relevant examinations should be considered to exclude the existence of autoimmune diseases like Sjogren's syndrome. [Mh] Termos MeSH primário: Hemorragia Cerebral/etiologia Pancitopenia/etiologia Síndrome de Sjogren/complicações [Mh] Termos MeSH secundário: Dexametasona/uso terapêutico Equimose/etiologia Feminino Glucocorticoides/uso terapêutico Cefaleia/etiologia Seres Humanos Imunoglobulinas Intravenosas/uso terapêutico Metilprednisolona/uso terapêutico Meia-Idade Convulsões/etiologia Síndrome de Sjogren/tratamento farmacológico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Glucocorticoids); 0 (Immunoglobulins, Intravenous); 7S5I7G3JQL (Dexamethasone); X4W7ZR7023 (Methylprednisolone) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180301 [Lr] Data última revisão: 180301 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008542

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[PMID]: 29390975 [Au] Autor: Yao W; Le Q [Ad] Endereço: Department of Ophthalmology, Eye & ENT Hospital of Fudan University, No.83 Fenyang Road, Shanghai, 200031, China. [Ti] Título: Social-economic analysis of patients with Sjogren's syndrome dry eye in East China: a cross-sectional study. [So] Source: BMC Ophthalmol;18(1):23, 2018 Feb 02. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Sjogren's syndrome is the leading cause for aqueous tear-deficiency dry eye. Little is known regarding the relationship between Sjogren's syndrome dry eye (SSDE) and patients' medical expenditure, clinical severity and psychological status changes. METHODS: Thirty-four SSDE patients and thirty non-Sjogren's syndrome dry eye (non-SSDE) subjects were enrolled. They were required to complete three self-report questionnaires: Ocular Surface Disease Index, Zung Self Rating Anxiety Scales, and a questionnaire designed by the researchers to study the patients' treatment, medical expenditure and income. The correlations between expenditures and these parameters were analyzed. RESULTS: The annual total expenditure on the treatment of SSDE was Chinese Yuan 7637.2 (approximately US$1173.8) on average, and the expense paid by SSDE patients themselves was Chinese Yuan 2627.8 (approximately US$403.9), which were 5.5 and 4.5 times higher than non-SSDE patients (both P < 0.001). The annual total expense on Chinese medicine and western medicine were 35.6 times and 78.4% higher in SSDE group than in non-SSDE group (both P < 0.001). Moreover, indirect costs associated with the treatment were 70.0% higher in SSDE group. In SSDE group, the score of Zung Self Rating Anxiety Scales had significantly positive correlation with total medical expenditure and the expense on Chinese medicine (ρ = 0.399 and ρ = 0.400,both P = 0.019). Nevertheless, total medical expenditure paid by the patients in non-SSDE group positively correlated with the score of Ocular Surface Disease Index (ρ = 0.386, P = 0.035). CONCLUSIONS: Medication expenditures and associated costs is an unignorable economic burden to the patients with SSDE. The medical expense had a significantly correlation with clinical severity of SSDE and the patients' psychological status. [Mh] Termos MeSH primário: Gastos em Saúde Acesso aos Serviços de Saúde/economia Síndrome de Sjogren/economia Fatores Socioeconômicos [Mh] Termos MeSH secundário: Atividades Cotidianas Adulto Idoso Grupo com Ancestrais do Continente Asiático/etnologia China/epidemiologia Estudos Transversais Síndromes do Olho Seco/tratamento farmacológico Síndromes do Olho Seco/economia Síndromes do Olho Seco/psicologia Feminino Seres Humanos Renda Masculino Meia-Idade Síndrome de Sjogren/tratamento farmacológico Síndrome de Sjogren/psicologia Inquéritos e Questionários [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180203 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0694-5

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[PMID]: 29309109 [Au] Autor: Bozic K; Glisic B; Radic-Tasic O; Knezevic B [Ti] Título: Case report of Mikulicz's disease: A modern concept of an old entity. [So] Source: Vojnosanit Pregl;73(4):393-6, 2016 Apr. [Is] ISSN: 0042-8450 [Cp] País de publicação: Serbia [La] Idioma: eng [Ab] Resumo: Introduction: Modern knowlegde defines Mikulicz´s disease as a part of immunoglobulin G4-related disease. The main feature is the presence of lymphoplasmacytic infiltrates, immunoglobulin G4 plasma cells positivity, distinctive storiform fibrosis and moderate eosinophilia. Case Report: A 59-years old male presented with a mild keratoconjuctivitis sicca and enlarged lacrimal and salivary glands during the last two years. Althought clinical presentation of the patient was typical, earlier testing did not pinpoint Mikulicz ´s disease. By typical clinical presentation, elevated serum immunoglobulin G4 level and histopathological finding of lacrimal glands tissue we diagnosed Mikulicz´s disease successfully treated with corticosteroid therapy. Conclusion: We reported the first case of IgG4-related Mikulicz´s disease in Serbia. Our report highlights IgG4-related Mikulicz` s disease as an important differential diagnosis with Sjögren`s syndrome and lymphoproliferative disease in rheumatological practice. [Mh] Termos MeSH primário: Doença de Mikulicz/diagnóstico [Mh] Termos MeSH secundário: Diagnóstico Diferencial Seres Humanos Imunoglobulina G/sangue Imunoglobulina G/metabolismo Imuno-Histoquímica Aparelho Lacrimal/imunologia Transtornos Linfoproliferativos/diagnóstico Masculino Meia-Idade Doença de Mikulicz/imunologia Plasmócitos/imunologia Sérvia Síndrome de Sjogren/diagnóstico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Immunoglobulin G) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180109 [St] Status: MEDLINE [do] DOI: 10.2298/VSP150118120B

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[PMID]: 29304089 [Au] Autor: Lin TM; Chen WS; Sheu JJ; Chen YH; Chen JH; Chang CC [Ad] Endereço: Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan. [Ti] Título: Autoimmune rheumatic diseases increase dementia risk in middle-aged patients: A nationwide cohort study. [So] Source: PLoS One;13(1):e0186475, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Dementia is a common neurological disease that substantially affects public health. A previous study revealed that dementia occurs when the body's immune system attacks the cells of the brain, indicating that dementia may be similar to autoimmune rheumatic diseases (ARDs). In the current retrospective cohort study, we focused on middle-aged ARD patients (45 years or older) to investigate the association between ARDs in middle-aged people and dementia by using a nationwide population-based database in Taiwan. METHOD: Our study analyzed the medical data of the Taiwanese population from 2001 to 2012, with a follow-up period extending until the end of 2011. We identified middle-aged patients with ARDs by using the Taiwan National Health Insurance Research Database. We selected a comparison cohort from the general population that was randomly frequency-matched by age (in 5-year increments), sex, and index year and further analyzed the dementia risk by using a Cox regression model that considers sex, age, and comorbidities. RESULTS: The study enrolled 34,660 middle-aged ARD patients (77% female, mean age = 59.8 years) and 138,640 controls. The risk of developing dementia was 1.18 times higher for middle-aged patients with ARDs compared with patients without ARDs after adjustment for age, sex, and comorbidities. Among the patients with ARDs, the subgroups with rheumatoid arthritis, systemic lupus erythematosus, and Sjögren syndrome (SS) were associated with a significantly higher dementia risk (adjusted hazard ratio [HR] 1.14, 95% confidence index [CI] 1.06-1.32; adjusted HR 1.07, 95% CI 0.86-1.34; adjusted HR 1.46, 95% CI 1.32-1.63, respectively). Furthermore, primary SS and secondary SS patients had the highest risks of dementia among all the ADR subgroups (adjusted HR 1.35, 95% CI 1.18-1.54; adjusted HR 1.67, 95% CI 1.43-1.95 respectively). CONCLUSION: This nationwide retrospective cohort study demonstrated that dementia risk is significantly higher in middle-aged patients with ARDs compared with the general population. [Mh] Termos MeSH primário: Doenças Autoimunes/epidemiologia Demência/epidemiologia Doenças Reumáticas/epidemiologia [Mh] Termos MeSH secundário: Idoso Idoso de 80 Anos ou mais Artrite Reumatoide/epidemiologia Estudos de Coortes Comorbidade Feminino Seres Humanos Incidência Lúpus Eritematoso Sistêmico/epidemiologia Masculino Meia-Idade Estudos Retrospectivos Fatores de Risco Síndrome de Sjogren/epidemiologia Taiwan/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180210 [Lr] Data última revisão: 180210 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180106 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0186475

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