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  1 / 1803 MEDLINE  
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[PMID]:29252740
[Au] Autor:Krochak R; Culbertson MD; Vigorita V; Goodman H
[Ad] Endereço:Departments of Orthopaedic Surgery (R.K., M.D.C., and H.G.) and Pathology (V.V.), Maimonides Medical Center, Brooklyn, New York.
[Ti] Título:Atypical Tumoral Presentation of Calcium Pyrophosphate Deposition Disease: A Case Report.
[So] Source:JBJS Case Connect;6(4):e86, 2016 Oct-Dec.
[Is] ISSN:2160-3251
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE: A 55-year-old man presented with a history of forefoot pain and swelling. Radiographs revealed a mass with internal calcifications and osseous erosion of the fifth metatarsophalangeal bone. The mass was isointense to muscle on T1-weighted magnetic resonance imaging (MRI) and hyperintense on T2-weighted MRI. A biopsy was performed, and intraoperatively, the lesion appeared as chalky white material, which under polarized light microscopy was composed of weakly positively birefringent rhomboid crystals, leading to a diagnosis of tophaceous pseudogout. CONCLUSION: Tophaceus pseudogout should be included in the differential diagnosis of neoplastic-appearing lesions in the foot, and polarized light microscopy should be used when examining biopsy specimens.
[Mh] Termos MeSH primário: Condrocalcinose/diagnóstico
Antepé Humano/diagnóstico por imagem
[Mh] Termos MeSH secundário: Condrocalcinose/patologia
Condrocalcinose/cirurgia
Diagnóstico Diferencial
Antepé Humano/cirurgia
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.CC.16.00050


  2 / 1803 MEDLINE  
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[PMID]:28524751
[Au] Autor:Bridges KJ; Bullis CL; Wanchu A; Than KD
[Ad] Endereço:Department of Neurological Surgery, and.
[Ti] Título:Pseudogout of the cervical and thoracic spine mimicking infection after lumbar fusion: case report.
[So] Source:J Neurosurg Spine;27(2):145-149, 2017 Aug.
[Is] ISSN:1547-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pseudogout is a form of acute calcium pyrophosphate deposition (CPPD) disease that typically afflicts the elderly. CPPD commonly involves larger joints, such as the knees, wrists, shoulders, and hips, and has been known to involve the spine. The authors report the case of a 66-year-old woman with a recent history of lumbar laminectomy and fusion who presented 5 weeks postprocedure with a clinical and radiographic picture consistent with multilevel skip lesions involving the cervical and thoracic spine, thoracic discitis, and epidural abscess. Serial blood cultures and repeat biopsy samples were sterile. Subsequent wrist and ankle erythema, pain, and swelling led to synovial fluid analysis, and pseudogout was diagnosed. She was treated with an interleukin-1 inhibitor with immediate symptom relief. To the authors' knowledge, this is only the second report of spinal pseudogout presenting with a clinical and radiographic picture consistent with discitis and epidural abscess. This report is the first to report skip lesions of pseudogout occurring throughout the spine that are uniquely remote from a recent lumbar surgery.
[Mh] Termos MeSH primário: Condrocalcinose/diagnóstico
Vértebras Lombares/cirurgia
Complicações Pós-Operatórias/diagnóstico
Doenças da Coluna Vertebral/diagnóstico
Fusão Vertebral
[Mh] Termos MeSH secundário: Idoso
Vértebras Cervicais/diagnóstico por imagem
Vértebras Cervicais/patologia
Condrocalcinose/tratamento farmacológico
Condrocalcinose/etiologia
Condrocalcinose/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Laminectomia
Vértebras Lombares/diagnóstico por imagem
Vértebras Lombares/patologia
Complicações Pós-Operatórias/tratamento farmacológico
Complicações Pós-Operatórias/patologia
Doenças da Coluna Vertebral/tratamento farmacológico
Doenças da Coluna Vertebral/etiologia
Doenças da Coluna Vertebral/patologia
Vértebras Torácicas/diagnóstico por imagem
Vértebras Torácicas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170520
[St] Status:MEDLINE
[do] DOI:10.3171/2016.12.SPINE16979


  3 / 1803 MEDLINE  
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[PMID]:28372716
[Au] Autor:Singh N; Vogelgesang SA
[Ad] Endereço:Division of Immunology: Rheumatology and Allergy, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C 42 GH, Iowa City, IA 52242, USA; Division of Immunology: Rheumatology and Allergy, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C 42 GH, Iowa City, IA 52242, USA.
[Ti] Título:Monoarticular Arthritis.
[So] Source:Med Clin North Am;101(3):607-613, 2017 May.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Monoarticular arthritis is inflammation characterized by joint pain, swelling, and sometimes periarticular erythema. Although chronic causes are seen, the onset is often acute. An infected joint can quickly lead to permanent damage, making it a medical emergency. However, acute gout presenting as monoarticular arthritis is often so uncomfortable it requires urgent attention. Monoarticular crystalline arthritis is common and a septic joint is a medical emergency so it is no surprise that these diagnoses come to mind with complaint of inflammation in 1 joint. However, there are many causes of monoarticular arthritis that clinicians must consider.
[Mh] Termos MeSH primário: Artrite/diagnóstico
Artrite/fisiopatologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Artrite/tratamento farmacológico
Artrite Infecciosa/diagnóstico
Artrite Infecciosa/fisiopatologia
Artrocentese/métodos
Condrocalcinose/diagnóstico
Condrocalcinose/fisiopatologia
Diagnóstico Diferencial
Gota/diagnóstico
Gota/fisiopatologia
Injeções Intra-Articulares
Sinovite/diagnóstico
Sinovite/fisiopatologia
Uricosúricos/uso terapêutico
Xantina Oxidase/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Uricosuric Agents); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


  4 / 1803 MEDLINE  
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[PMID]:28339356
[Au] Autor:Di Matteo A; Filippucci E; Salaffi F; Carotti M; Carboni D; Di Donato E; Grassi W
[Ad] Endereço:Clinica Reumatologica, "C. Urbani" Hospital, Università Politecnica delle Marche, Jesi, Ancona, Italy. andrea.dimatteo@hotmail.com.
[Ti] Título:Diagnostic accuracy of musculoskeletal ultrasound and conventional radiography in the assessment of the wrist triangular fibrocartilage complex in patients with definite diagnosis of calcium pyrophosphate dihydrate deposition disease.
[So] Source:Clin Exp Rheumatol;35(4):647-652, 2017 Jul-Aug.
[Is] ISSN:0392-856X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To compare the diagnostic accuracy of musculoskeletal ultrasound (MSUS) and x-ray in evaluating wrist triangular fibrocartilage complex (TFCC) in patients with calcium pyrophosphate dihydrate deposition disease (CPPD) and to investigate the agreement between the extent of the calcium pyrophosphate dihydrate (CPP) crystal deposits assessed by MSUS and the radiographic findings. METHODS: We enrolled 84 patients: 36 patients with "definite" CPPD and 48 controls. The Ryan and McCarty diagnostic criteria were used. A rheumatologist performed bilateral MSUS examinations of the TFCC in all patients, assessing both the presence and absence of CCP crystals deposits and their extent (0-3; 0: absent; 1: 1-2 spots; 2: more than two spots covering <50% of the volume of the structure; 3: deposits covering >50% of the volume of the structure). A radiologist evaluated the presence/absence of x-ray calcifications at TFCC level in both groups. RESULTS: MSUS and x-ray sensitivity was 77.8% and 76.4%, respectively, whereas MSUS and x-ray specificity was 90.6% and 96.9%, respectively. Total agreement between MSUS and radiographic findings indicative of calcifications at TFCC level was 88.7%. CONCLUSIONS: This study supports the diagnostic accuracy of MSUS and x-ray in evaluating TFCC crystal deposits in patients with CPPD. Sensitivity and specificity of MSUS and x-ray resulted comparable. The highest MSUS score of the extent of the deposits correlated better with x-ray findings.
[Mh] Termos MeSH primário: Condrocalcinose/diagnóstico por imagem
Fibrocartilagem Triangular/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Radiografia
Sensibilidade e Especificidade
Ultrassonografia
Articulação do Punho/diagnóstico por imagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


  5 / 1803 MEDLINE  
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[PMID]:28328803
[Au] Autor:Roddy E; Muller S; Paskins Z; Hider SL; Blagojevic-Bucknall M; Mallen CD
[Ad] Endereço:Research Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire, UK.
[Ti] Título:Incident acute pseudogout and prior bisphosphonate use: Matched case-control study in the UK-Clinical Practice Research Datalink.
[So] Source:Medicine (Baltimore);96(12):e6177, 2017 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oral bisphosphonates are the most commonly used drugs to treat postmenopausal osteoporosis. Acute pseudogout is anecdotally reported to occur following bisphosphonate initiation but empirical data are lacking. We investigated whether treatment with oral bisphosphonates is a risk factor for incident acute pseudogout.A matched case-control study was undertaken using data from the UK-Clinical Practice Research Datalink. Adults who consulted for incident acute pseudogout between 1987 and 2012 were each matched for gender, age at pseudogout diagnosis, and general practice to up to 4 control subjects without pseudogout. The exposure of interest was a prescription for an oral bisphosphonate issued within the 60-day period prior to the date of incident acute pseudogout. Associations between incident acute pseudogout and prior bisphosphonate prescription were examined using conditional logistic regression, adjusting for hyperparathyroidism, osteoarthritis, rheumatoid arthritis, hemochromatosis, hypophosphatasia, and prescriptions for diuretics and oral corticosteroids.Two thousand eleven acute pseudogout cases were compared with 8013 matched controls without acute pseudogout (mean age [standard deviation] 72 years [14]; 52% male). One hundred twenty-three cases (6.1%) had received an oral bisphosphonate prescription in the 60-day exposure period compared with 305 controls (3.8%) (adjusted incidence rate ratio [IRR] 1.33; 95% confidence interval [CI] 1.05-1.69). This association was stronger in females (adjusted IRR 1.49; 95% CI 1.15-1.94) and was nonsignificant in males (0.83; 0.48-1.44).Incident acute pseudogout was associated with prescription of an oral bisphosphonate in the preceding 60 days. Prescribers should be aware of acute pseudogout as a possible side effect of bisphosphonate treatment. Further research is needed to explore the risks conferred by different bisphosphonates and the mechanism underlying this association.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/efeitos adversos
Condrocalcinose/induzido quimicamente
Difosfonatos/efeitos adversos
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Feminino
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Bone Density Conservation Agents); 0 (Diphosphonates)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000006177


  6 / 1803 MEDLINE  
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[PMID]:28129488
[Au] Autor:Han BK; Kim W; Niu J; Basnyat S; Barshay V; Gaughan JP; Williams C; Kolasinski SL; Felson DT
[Ad] Endereço:University of Washington School of Medicine, Seattle.
[Ti] Título:Association of Chondrocalcinosis in Knee Joints With Pain and Synovitis: Data From the Osteoarthritis Initiative.
[So] Source:Arthritis Care Res (Hoboken);69(11):1651-1658, 2017 Nov.
[Is] ISSN:2151-4658
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the relationship between chondrocalcinosis and pain or synovitis in knee joints by examining data from the Osteoarthritis Initiative (OAI). METHODS: Data were obtained from the OAI public-use data sets. The relationship between chondrocalcinosis on baseline knee radiograph and pain at baseline and at 4 years was examined. Analyses were adjusted for age, sex, body mass index, and Kellgren-Lawrence (K/L) grade and the correlation between 2 knees in a subject was controlled using generalized estimating equations. The relationship between chondrocalcinosis and synovitis on magnetic resonance imaging (MRI) was examined by comparing knees with chondrocalcinosis at baseline and age, sex, and K/L grade-matched knees with no chondrocalcinosis. We read MRIs of a subset of knees for synovitis using the MRI Osteoarthritis Knee Score (MOAKS) on baseline and 4-year MRI. RESULTS: Knees with chondrocalcinosis (n = 162) more often had pain compared to knees without chondrocalcinosis (n = 2,030) at baseline and had higher Western Ontario and McMaster Universities Osteoarthritis Index pain scores, both at baseline (mean 2.4 [95% confidence interval (95% CI) 1.9, 2.9]) versus mean 1.8 [95% CI 1.7, 1.9]) and at 4 years (mean 2.5 [95% CI 1.9, 3.1] versus mean 1.6 [95% CI 1.5, 1.8]), as well as higher Intermittent and Constant Osteoarthritis Pain intermittent pain scores at 4 years. There was no difference in MOAKS synovitis scores at baseline and at 4 years between the chondrocalcinosis group (n = 102) and the control group (n = 99). CONCLUSION: Knees with chondrocalcinosis had increased pain and did not have higher synovitis scores on MRI compared to knees without chondrocalcinosis. The mechanisms by which chondrocalcinosis is associated with increased pain remain to be determined.
[Mh] Termos MeSH primário: Artralgia/diagnóstico por imagem
Condrocalcinose/diagnóstico por imagem
Bases de Dados Factuais
Articulação do Joelho/diagnóstico por imagem
Sinovite/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Artralgia/epidemiologia
Condrocalcinose/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Osteoartrite do Joelho
Medição da Dor/métodos
Estudos Prospectivos
Sinovite/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1002/acr.23208


  7 / 1803 MEDLINE  
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[PMID]:28003083
[Au] Autor:Blanchard A; Bockenhauer D; Bolignano D; Calò LA; Cosyns E; Devuyst O; Ellison DH; Karet Frankl FE; Knoers NV; Konrad M; Lin SH; Vargas-Poussou R
[Ad] Endereço:Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Centre d'Investigation Clinique, Paris, France; Centre d'Investigation Clinique 1418, Institut National de la Santé et de la Recherche Médica
[Ti] Título:Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
[So] Source:Kidney Int;91(1):24-33, 2017 Jan.
[Is] ISSN:1523-1755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Gitelman syndrome (GS) is a rare, salt-losing tubulopathy characterized by hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria. The disease is recessively inherited, caused by inactivating mutations in the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter (NCC). GS is usually detected during adolescence or adulthood, either fortuitously or in association with mild or nonspecific symptoms or both. The disease is characterized by high phenotypic variability and a significant reduction in the quality of life, and it may be associated with severe manifestations. GS is usually managed by a liberal salt intake together with oral magnesium and potassium supplements. A general problem in rare diseases is the lack of high quality evidence to inform diagnosis, prognosis, and management. We report here on the current state of knowledge related to the diagnostic evaluation, follow-up, management, and treatment of GS; identify knowledge gaps; and propose a research agenda to substantiate a number of issues related to GS. This expert consensus statement aims to establish an initial framework to enable clinical auditing and thus improve quality control of care.
[Mh] Termos MeSH primário: Síndrome de Bartter/diagnóstico
Condrocalcinose/etiologia
Suplementos Nutricionais
Síndrome de Gitelman/diagnóstico
Síndrome de Gitelman/tratamento farmacológico
[Mh] Termos MeSH secundário: Antagonistas de Receptores de Angiotensina/uso terapêutico
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Síndrome de Bartter/sangue
Síndrome de Bartter/genética
Síndrome de Bartter/urina
Cálcio/urina
Canais de Cloreto/genética
Condrocalcinose/prevenção & controle
Conferências de Consenso como Assunto
Diagnóstico Diferencial
Testes Genéticos
Síndrome de Gitelman/complicações
Síndrome de Gitelman/genética
Seres Humanos
Hipopotassemia/sangue
Hipopotassemia/genética
Magnésio/administração & dosagem
Magnésio/sangue
Magnésio/uso terapêutico
Mutação
Fenótipo
Potássio/administração & dosagem
Potássio/sangue
Potássio/uso terapêutico
Guias de Prática Clínica como Assunto
Qualidade de Vida
Doenças Raras/genética
Cloreto de Sódio na Dieta/uso terapêutico
Membro 3 da Família 12 de Carreador de Soluto/genética
Ultrassonografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiotensin Receptor Antagonists); 0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (CLCNKB protein, human); 0 (Chloride Channels); 0 (SLC12A3 protein, human); 0 (Sodium Chloride, Dietary); 0 (Solute Carrier Family 12, Member 3); I38ZP9992A (Magnesium); RWP5GA015D (Potassium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE


  8 / 1803 MEDLINE  
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[PMID]:27941391
[Au] Autor:Carlson AK; McCutchen CN; June RK
[Ad] Endereço:aDepartment of Cell Biology & Neuroscience bDepartment of Mechanical & Industrial Engineering, Montana State University, Bozeman, Montana, USA.
[Ti] Título:Mechanobiological implications of articular cartilage crystals.
[So] Source:Curr Opin Rheumatol;29(2):157-162, 2017 Mar.
[Is] ISSN:1531-6963
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Calcium crystals exist in both pathological and normal articular cartilage. The prevalence of these crystals dramatically increases with age, and crystals are typically found in osteoarthritic cartilage and synovial fluid. Relatively few studies have examined the effects of crystals on cartilage biomechanics or chondrocyte mechanotransduction. The purpose of this review is to describe how crystals could influence cartilage biomechanics and mechanotransduction in osteoarthritis. RECENT FINDINGS: Crystals are found in both loaded and unloaded regions of articular cartilage. Exogenous crystals, in combination with joint motion, result in substantial joint inflammation. Articular cartilage vesicles promote crystal formation, and these vesicles are found near the periphery of chondrocytes. Crystallographic studies report monoclinic symmetry for synthetic crystals, suggesting that crystals will have a large stiffness compared with the cartilage extracellular matrix, the pericellular matrix, or the chondrocyte. This stiffness imbalance may cause crystal-induced dysregulation of chondrocyte mechanotransduction promoting both aging and osteoarthritis chondrocyte phenotypes. SUMMARY: Because of their high stiffness compared with cartilage matrix, crystals likely alter chondrocyte mechanotransduction, and high concentrations of crystals within cartilage may alter macroscale biomechanics. Future studies should focus on understanding the mechanical properties of joint crystals and developing methods to understand how crystals affect chondrocyte mechanotransduction.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/metabolismo
Pirofosfato de Cálcio/metabolismo
Cartilagem Articular/metabolismo
Condrocalcinose/metabolismo
Condrócitos/metabolismo
Matriz Extracelular/metabolismo
Osteoartrite/metabolismo
[Mh] Termos MeSH secundário: Cartilagem Articular/citologia
Cartilagem Articular/fisiopatologia
Condrocalcinose/fisiopatologia
Condrócitos/citologia
Seres Humanos
Mecanotransdução Celular/fisiologia
Osteoartrite/fisiopatologia
Estresse Mecânico
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Phosphates); 97Z1WI3NDX (calcium phosphate); X69NU20D19 (Calcium Pyrophosphate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE
[do] DOI:10.1097/BOR.0000000000000368


  9 / 1803 MEDLINE  
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[PMID]:27898996
[Au] Autor:Kleiber Balderrama C; Rosenthal AK; Lans D; Singh JA; Bartels CM
[Ad] Endereço:Medical College of Wisconsin and the Clement J. Zablocki VA Medical Center, Milwaukee, Wisconsin.
[Ti] Título:Calcium Pyrophosphate Deposition Disease and Associated Medical Comorbidities: A National Cross-Sectional Study of US Veterans.
[So] Source:Arthritis Care Res (Hoboken);69(9):1400-1406, 2017 Sep.
[Is] ISSN:2151-4658
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Calcium pyrophosphate deposition disease (CPDD) is a common cause of acute and chronic arthritis, yet there are few large epidemiologic studies of CPDD. We sought to characterize CPDD in the national Veterans Affairs (VA) population. METHODS: Using data from the Department of VA Corporate Data Warehouse, patients with International Classification of Diseases, Ninth Revision, codes for CPDD seen at any VA medical center from 2010 through 2014 were matched by age and sex with control patients without CPDD. We used multivariate analysis to compare the prevalence and odds ratios (ORs) of various comorbidities, substance use, medication exposures, and arthroplasties among patients with and without CPDD. RESULTS: We identified 25,157 patients with CPDD, yielding a point prevalence of 5.2 per 1,000. The mean ± SD age was 68.1 ± 12.3 years, and 95% were male. The strongest positive associations with CPDD were hyperparathyroidism (OR 3.35 [95% confidence interval (95% CI) 2.96-3.79]), gout (OR 2.82 [95% CI 2.69-2.95]), osteoarthritis (OR 2.26 [95% CI 2.15-2.37]), rheumatoid arthritis (OR 1.88 [95% CI 1.74-2.03]), and hemochromatosis (OR 1.87 [95% CI 1.57-2.24]). Positive associations were also seen with higher odds for osteoporosis (OR 1.26 [95% CI 1.16-1.36]), hypomagnesemia (OR 1.23 [95% CI 1.16-1.30]), chronic kidney disease (OR 1.12 [95% CI 1.07-1.18]), and calcium supplementation (OR 1.15 [95% CI 1.06-1.24). Negative associations were seen with proton-pump inhibitors (OR 0.58 [95% CI 0.55-0.60]) and loop diuretics (OR 0.80 [95% CI 0.76-0.84]). CONCLUSION: Using a large national data set, we confirmed known associations with CPDD, provided support for positive associations with rheumatoid arthritis, hypomagnesemia, and osteoporosis, and suggested potential novel negative associations with commonly used medications.
[Mh] Termos MeSH primário: Condrocalcinose/epidemiologia
Veteranos/estatística & dados numéricos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Artrite Reumatoide/epidemiologia
Estudos de Casos e Controles
Comorbidade
Estudos Transversais
Feminino
Gota/epidemiologia
Hemocromatose/epidemiologia
Seres Humanos
Hiperparatireoidismo/epidemiologia
Deficiência de Magnésio/epidemiologia
Masculino
Meia-Idade
Razão de Chances
Osteoartrite/epidemiologia
Osteoporose/epidemiologia
Insuficiência Renal Crônica/epidemiologia
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171001
[Lr] Data última revisão:
171001
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1002/acr.23160


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[PMID]:25786825
[Au] Autor:Kumar V; Pandit HG; Liddle AD; Borror W; Jenkins C; Mellon SJ; Hamilton TW; Athanasou N; Dodd CA; Murray DW
[Ad] Endereço:Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3 7LD, UK.
[Ti] Título:Comparison of outcomes after UKA in patients with and without chondrocalcinosis: a matched cohort study.
[So] Source:Knee Surg Sports Traumatol Arthrosc;25(1):319-324, 2017 Jan.
[Is] ISSN:1433-7347
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Chondrocalcinosis can be associated with an inflammatory arthritis and aggressive joint destruction. There is uncertainty as to whether chondrocalcinosis represents a contraindication to unicompartmental knee arthroplasty (UKA). This study reports the outcome of a consecutive series of patients with chondrocalcinosis and medial compartment osteoarthritis treated with UKA matched to controls. METHODS: Between 1998 and 2008, 88 patients with radiological chondrocalcinosis (R-CCK) and 67 patients with histological chondrocalcinosis (H-CCK) were treated for end-stage medial compartment arthritis with Oxford UKA. One-to-two matching was performed to controls, treated with UKA, but without evidence of chondrocalcinosis. Functional outcome and implant survival were assessed in each group. RESULTS: The mean follow-up was 10 years. The mean Oxford Knee Score (OKS) at final follow-up was 43, 41 and 41 in H-CCK, R-CCK and control groups (change from baseline OKS was 21, 18 and 15, respectively). The change was significantly higher in H-CCK than in control but was not significantly different in R-CCK. Ten-year survival was 96 % in R-CCK, 86 % in H-CCK and 98 % in controls. Although the survival in H-CCK was significantly worse than in control, only one failure was due to disease progression. CONCLUSION: The presence of R-CCK does not influence functional outcome or survival following UKA. Pre-operative radiological evidence of CCK should not be considered to be a contraindication to UKA. H-CCK is associated with significantly improved clinical outcomes but also a higher revision rate compared with controls. LEVEL OF EVIDENCE: Case control study, Level III.
[Mh] Termos MeSH primário: Artroplastia do Joelho
Condrocalcinose/complicações
Osteoartrite do Joelho/cirurgia
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Condrocalcinose/diagnóstico por imagem
Condrocalcinose/patologia
Estudos de Coortes
Progressão da Doença
Feminino
Seres Humanos
Estimativa de Kaplan-Meier
Prótese do Joelho
Masculino
Meia-Idade
Osteoartrite do Joelho/complicações
Modelos de Riscos Proporcionais
Radiografia
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150320
[St] Status:MEDLINE
[do] DOI:10.1007/s00167-015-3578-8



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