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[PMID]:28538571
[Au] Autor:Taylor GI; Sparks DS; Gascoigne AC; Corlett RJ; Ashton MW
[Ad] Endereço:Melbourne, Victoria, Australia From the Taylor Lab, Department of Anatomy and Neuroscience, University of Melbourne; and the PA-Southside Clinical School, School of Medicine, University of Queensland, Brisbane.
[Ti] Título:Angiosome-Based Allografts: Vascularized Composite Allotransplantation for Tailored Subunit Reconstruction with Volkmann Ischemic Contracture as a Case in Point.
[So] Source:Plast Reconstr Surg;139(6):1291e-1304e, 2017 Jun.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: As we enter an age with new approaches to tissue reconstruction, the emphasis on the adage "like for like" has become even more relevant. This study illustrates the potential for several tailored vascularized composite allotransplantation reconstructive techniques and, in particular, for the management of Volkmann contracture. METHODS: Twenty fresh cadaver dissections and 30 archival lead oxide radiographic studies were examined to (1) identify potential upper limb vascularized composite allotransplantation donor sites (i.e., elbow, forearm, and flexor tendon complex) and (2) demonstrate a "mock transplant" of the vascularized volar forearm allograft for a severe Volkmann ischemia defect. They were designed without skin to reduce antigenicity. RESULTS: The elbow joint was supplied within the brachial angiosome and the flexor tendon complex of the flexor digitorum superficialis and flexor digitorum profundus by the superficial palmar arch of the ulnar angiosome. The forearm allograft of flexor muscles, median, ulnar, and anterior interosseous nerves, when harvested on the brachial vessels, was supplied within the radial, ulnar, and anterior interosseous angiosomes but could be based on the ulnar artery alone because of intramuscular connections with the other territories. A mock transplant was performed with a distal-to-proximal dissection of the allograft, facilitating the best and fastest technique. CONCLUSIONS: This application of the angiosome concept highlights the anatomical feasibility of the volar forearm vascularized composite allotransplantation donor site focusing on a complex subunit problem in the upper limb-severe Volkmann ischemic contracture. It demonstrates the potential use and immunologic advantage of subdivided and modified nonskin variations of vascularized composite allotransplantation in reconstructive transplantation surgery. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.
[Mh] Termos MeSH primário: Contratura Isquêmica/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Alotransplante de Tecidos Compostos Vascularizados/métodos
[Mh] Termos MeSH secundário: Idoso
Cadáver
Estudos de Viabilidade
Feminino
Antebraço/irrigação sanguínea
Antebraço/cirurgia
Seres Humanos
Masculino
Meia-Idade
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170525
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003360


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[PMID]:28072735
[Au] Autor:Kaji Y; Nakamura O; Yamaguchi K; Tobiume S; Yamamoto T
[Ad] Endereço:Department of Orthopaedic Surgery, Kagawa University Faculty of Medicine, Kagawa, Japan.
[Ti] Título:Localized type Volkmann's contracture treated with tendon transfer and tension-reduced early mobilization: A case report.
[So] Source:Medicine (Baltimore);96(1):e5807, 2017 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: For localized type Volkmann's contracture, in which degeneration of the flexor digitorum profundus (FDP) muscle to one or two fingers and restriction of finger extension occur, dissection or excision of the affected muscle is usually recommended. However, these surgical procedures need relatively wide exposure of the muscle, because the FDP muscle is in the deep portion of the forearm. PATIENT CONCERNS: In this report, the case of a 35-year-old woman with localized type Volkmann's contracture is presented. Her left forearm had been compressed with an industrial roller 4 months earlier, and severe flexion contracture of the long finger and mild flexion contracture of the ring finger developed gradually. DIAGNOSES:: localized type Volkmann's contracture. INTERVENTION: Five months after the injury, transection of the FDP tendon to the long finger and transfer of the transected tendon to the FDP tendon to the index finger was performed after adjusting the tonus of these two tendons using a small skin incision. This procedure was followed by a tension-reduced early mobilization technique in which a tension-reduced position of the tendon suture site was maintained by taping the long finger to the volar side of the index finger, and then immediate active range of motion (ROM) exercise was started. OUTCOMES: Within 9 weeks after surgery, full ROM had been regained. LESSONS: Using the treatment procedure presented in this case report, a good clinical result was obtained in a minimally invasive manner.
[Mh] Termos MeSH primário: Dedos
Contratura Isquêmica
Transferência Tendinosa/métodos
Tendões
[Mh] Termos MeSH secundário: Adulto
Deambulação Precoce/métodos
Feminino
Dedos/fisiopatologia
Dedos/cirurgia
Seres Humanos
Contratura Isquêmica/diagnóstico
Contratura Isquêmica/etiologia
Contratura Isquêmica/fisiopatologia
Contratura Isquêmica/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Recuperação de Função Fisiológica
Tendões/fisiopatologia
Tendões/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000005807


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[PMID]:27329788
[Au] Autor:Jaryal A; Vikrant S; Thakur P
[Ad] Endereço:Department of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, 171001 India.
[Ti] Título:Volkmann's ischemic contracture: An unusual complication of arterio-venous fistula.
[So] Source:Hemodial Int;21(1):E1-E3, 2017 Jan.
[Is] ISSN:1542-4758
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Native arterio-venous fistulae (AVF) are vascular access of first choice for chronic hemodialysis. However, AVF are also associated with many adverse events like: primary or secondary failure, infection, lymphedema, stenosis, thrombosis, and ischemia of distal extremities. The most common ischemia related complications of AVF are: ischemic neuropathy and steal syndrome with its consequences like pain and peripheral necrosis. Ischemic muscle contracture is a rare complication of AVF. Herein, we are reporting a case of Volkmann's ischemic contracture developing after creation of brachiocephalic AVF.
[Mh] Termos MeSH primário: Fístula Arteriovenosa/complicações
Contratura Isquêmica/etiologia
Diálise Renal/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.1111/hdi.12444


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[PMID]:27094895
[Au] Autor:Krauss EM; Tung TH; Moore AM
[Ad] Endereço:Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, Saint Louis, MO 63110, USA.
[Ti] Título:Free Functional Muscle Transfers to Restore Upper Extremity Function.
[So] Source:Hand Clin;32(2):243-56, 2016 May.
[Is] ISSN:1558-1969
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Free functional muscle transfer provides an option for functional restoration when nerve reconstruction and tendon transfers are not feasible. To ensure a successful outcome, many factors need to be optimized, including proper patient selection, timing of intervention, donor muscle and motor nerve selection, optimal microneurovascular technique and tension setting, proper postoperative management, and appropriate rehabilitation. Functional outcomes of various applications to the upper extremity and the authors' algorithm for the use of free functional muscle transfer are also included in this article.
[Mh] Termos MeSH primário: Traumatismos do Braço/cirurgia
Músculo Esquelético/transplante
Traumatismos dos Nervos Periféricos/cirurgia
Extremidade Superior/cirurgia
[Mh] Termos MeSH secundário: Traumatismos do Braço/diagnóstico
Traumatismos do Braço/reabilitação
Neuropatias do Plexo Braquial/diagnóstico
Neuropatias do Plexo Braquial/cirurgia
Seres Humanos
Contratura Isquêmica/diagnóstico
Contratura Isquêmica/cirurgia
Músculo Esquelético/cirurgia
Traumatismos dos Nervos Periféricos/diagnóstico
Procedimentos Cirúrgicos Reconstrutivos
Recuperação de Função Fisiológica
Transferência Tendinosa
Doadores de Tecidos
Resultado do Tratamento
Extremidade Superior/lesões
Extremidade Superior/inervação
Extremidade Superior/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160421
[St] Status:MEDLINE


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[PMID]:27041248
[Au] Autor:Lee BK; Kim MJ; Jeung KW; Choi SS; Park SW; Yun SW; Lee SM; Lee DH; Min YI
[Ad] Endereço:Department of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
[Ti] Título:2,3-Butanedione monoxime facilitates successful resuscitation in a dose-dependent fashion in a pig model of cardiac arrest.
[So] Source:Am J Emerg Med;34(6):1053-8, 2016 Jun.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Ischemic contracture compromises the hemodynamic effectiveness of cardiopulmonary resuscitation (CPR) and resuscitability from cardiac arrest. In a pig model of cardiac arrest, 2,3-butanedione monoxime (BDM) attenuated ischemic contracture. We investigated the effects of different doses of BDM to determine whether increasing the dose of BDM could improve the hemodynamic effectiveness of CPR further, thus ultimately improving resuscitability. METHODS: After 16minutes of untreated ventricular fibrillation and 8minutes of basic life support, 36 pigs were divided randomly into 3 groups that received 50mg/kg (low-dose group) of BDM, 100mg/kg (high-dose group) of BDM, or an equivalent volume of saline (control group) during advanced cardiovascular life support. RESULTS: During advanced cardiovascular life support, the control group showed an increase in left ventricular (LV) wall thickness and a decrease in LV chamber area. In contrast, the BDM-treated groups showed a decrease in the LV wall thickness and an increase in the LV chamber area in a dose-dependent fashion. Mixed-model analyses of the LV wall thickness and LV chamber area revealed significant group effects and group-time interactions. Central venous oxygen saturation at 3minutes after the drug administration was 21.6% (18.4-31.9), 39.2% (28.8-53.7), and 54.0% (47.5-69.4) in the control, low-dose, and high-dose groups, respectively (P<.001). Sustained restoration of spontaneous circulation was attained in 7 (58.3%), 10 (83.3%), and 12 animals (100%) in the control, low-dose, and high-dose groups, respectively (P=.046). CONCLUSION: 2,3-Butanedione monoxime administered during CPR attenuated ischemic contracture and improved the resuscitability in a dose-dependent fashion.
[Mh] Termos MeSH primário: Reanimação Cardiopulmonar
Diacetil/análogos & derivados
Inibidores Enzimáticos/uso terapêutico
Parada Cardíaca/terapia
Contratura Isquêmica/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Diacetil/uso terapêutico
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Parada Cardíaca/etiologia
Contratura Isquêmica/etiologia
Suínos
Fibrilação Ventricular/complicações
Função Ventricular Esquerda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 19SQ93LM6H (diacetylmonoxime); K324J5K4HM (Diacetyl)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE


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[PMID]:26495537
[Au] Autor:Hindemith J; Uphoff R
[Ti] Título:[Compartment syndrome and Volkmann contracture].
[Ti] Título:Kompartmentsyndrom und Volkmann'sche Kontraktur..
[So] Source:Kinderkrankenschwester;34(8):301-3, 2015 Aug.
[Is] ISSN:0723-2276
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Moldes Cirúrgicos
Síndromes Compartimentais/enfermagem
Fixação Interna de Fraturas/enfermagem
Fraturas do Úmero/enfermagem
Contratura Isquêmica/enfermagem
Complicações Pós-Operatórias/enfermagem
[Mh] Termos MeSH secundário: Criança
Síndromes Compartimentais/diagnóstico
Síndromes Compartimentais/cirurgia
Diagnóstico Tardio
Diagnóstico Diferencial
Prova Pericial/legislação & jurisprudência
Seres Humanos
Fraturas do Úmero/diagnóstico
Fraturas do Úmero/cirurgia
Contratura Isquêmica/diagnóstico
Contratura Isquêmica/cirurgia
Masculino
Imperícia/legislação & jurisprudência
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/cirurgia
Reoperação
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE


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[PMID]:25606703
[Au] Autor:Thind GS; Agrawal PR; Hirsh B; Saravolatz L; Chen-Scarabelli C; Narula J; Scarabelli TM
[Ad] Endereço:SDM College of Medical Sciences & Hospital, Dharwad, Karnataka, India.
[Ti] Título:Mechanisms of myocardial ischemia-reperfusion injury and the cytoprotective role of minocycline: scope and limitations.
[So] Source:Future Cardiol;11(1):61-76, 2015.
[Is] ISSN:1744-8298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Deep insight into the complex mechanisms of myocardial ischemia-reperfusion injury has been attained in the past years. Minocycline is a second-generation tetracycline with US FDA approval for clinical use in various infections. Lately, several noninfectious cytoprotective activities of minocycline have been discovered as well. There now exists encouraging evidence of its protective role in cardiovascular pathology and its activity against myocardial ischemia-reperfusion injury. In this article, an overview of the major mechanisms involved in myocardial ischemia-reperfusion injury is presented. This is followed by an analysis of the mechanisms by which minocycline exerts its cytoprotective role and of studies that have been conducted in order to analyze minocycline, along with a review of the scope and limitations of its role as a cytoprotective agent.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Minociclina/farmacologia
Traumatismo por Reperfusão Miocárdica/tratamento farmacológico
[Mh] Termos MeSH secundário: Apoptose
Cálcio/metabolismo
Citoproteção/efeitos dos fármacos
Proteína HMGB1/efeitos dos fármacos
Proteína HMGB1/metabolismo
Seres Humanos
Concentração de Íons de Hidrogênio
Inflamação/tratamento farmacológico
Inflamação/fisiopatologia
Contratura Isquêmica/fisiopatologia
Metaloproteinases da Matriz/efeitos dos fármacos
Metaloproteinases da Matriz/metabolismo
Proteínas de Transporte da Membrana Mitocondrial/fisiologia
Traumatismo por Reperfusão Miocárdica/fisiopatologia
Miocárdio/patologia
Necrose
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (HMGB1 Protein); 0 (HMGB1 protein, human); 0 (Mitochondrial Membrane Transport Proteins); 0 (Reactive Oxygen Species); 0 (mitochondrial permeability transition pore); EC 3.4.24.- (Matrix Metalloproteinases); FYY3R43WGO (Minocycline); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150122
[Lr] Data última revisão:
150122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150122
[St] Status:MEDLINE
[do] DOI:10.2217/fca.14.76


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[PMID]:25450568
[Au] Autor:Lee BK; Jeung KW; Choi SS; Park SW; Yun SW; Lee SM; Kim NY; Heo T; Min YI
[Ad] Endereço:Department of Emergency Medicine, Chonnam National University Hospital, 42, Jebong-ro, Donggu, Gwangju, Republic of Korea. Electronic address: bbukkuk@hanmail.net.
[Ti] Título:Effects of the administration of 2,3-butanedione monoxime during conventional cardiopulmonary resuscitation on ischaemic contracture and resuscitability in a pig model of out-of-hospital cardiac arrest.
[So] Source:Resuscitation;87:26-32, 2015 Feb.
[Is] ISSN:1873-1570
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:AIM OF THE STUDY: Ischaemic contracture compromises the haemodynamic effectiveness of cardiopulmonary resuscitation and resuscitability. 2,3-Butanedione monoxime (BDM) reduced ischaemic contracture by inhibiting actin-myosin crossbridge formation in an isolated heart model. We investigated the effects of BDM on ischaemic contracture and resuscitation outcomes in a pig model of out-of-hospital cardiac arrest (OHCA). METHODS: After 15min of untreated ventricular fibrillation, followed by 8min of basic life support, 16 pigs were randomised to receive either 2mlkg(-1) of BDM solution (25gl(-1)) or 2mlkg(-1) of saline during advanced cardiac life support (ACLS). RESULTS: During the ACLS, the control group showed an increase in left ventricular (LV) wall thickness from 10.0mm (10.0-10.8) to 13.0mm (13.0-13.0) and a decrease in LV chamber area from 8.13cm(2) (7.59-9.29) to 7.47cm(2) (5.84-8.43). In contrast, the BDM group showed a decrease in the LV wall thickness from 10mm (9.0-10.8) to 8.5mm (7.0-9.8) and an increase in the LV chamber area from 9.86cm(2) (7.22-12.39) to 12.15 cm(2) (8.02-14.40). Mixed model analyses of the LV wall thickness and LV chamber area revealed significant group effects and group-time interactions. Spontaneous circulation was restored in four (50%) animals in the control group and in eight (100%) animals in the BDM group (p=0.077). All the resuscitated animals survived during an intensive care period of 4h. CONCLUSION: BDM administered during cardiopulmonary resuscitation reversed ischaemic contracture in a pig model of OHCA.
[Mh] Termos MeSH primário: Suporte Vital Cardíaco Avançado/métodos
Diacetil/análogos & derivados
Contratura Isquêmica
Parada Cardíaca Extra-Hospitalar
[Mh] Termos MeSH secundário: Animais
Diacetil/farmacologia
Modelos Animais de Doenças
Monitoramento de Medicamentos
Inibidores Enzimáticos/farmacologia
Ventrículos do Coração/efeitos dos fármacos
Ventrículos do Coração/patologia
Contratura Isquêmica/etiologia
Contratura Isquêmica/patologia
Contratura Isquêmica/prevenção & controle
Parada Cardíaca Extra-Hospitalar/complicações
Parada Cardíaca Extra-Hospitalar/terapia
Suínos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 19SQ93LM6H (diacetylmonoxime); K324J5K4HM (Diacetyl)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150113
[Lr] Data última revisão:
150113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141203
[St] Status:MEDLINE


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[PMID]:25361847
[Au] Autor:Alton TB; Werner SE; Gee AO
[Ad] Endereço:Department of Orthopaedics and Sports Medicine, University of Washington, 7201 6th Avenue, NE, #102, Seattle, WA, 98115, USA, altont@uw.edu.
[Ti] Título:Classifications in brief: the Gartland classification of supracondylar humerus fractures.
[So] Source:Clin Orthop Relat Res;473(2):738-41, 2015 Feb.
[Is] ISSN:1528-1132
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Fraturas do Úmero/classificação
[Mh] Termos MeSH secundário: Vasos Sanguíneos/lesões
Seres Humanos
Fraturas do Úmero/complicações
Fraturas do Úmero/terapia
Contratura Isquêmica/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1503
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:141102
[St] Status:MEDLINE
[do] DOI:10.1007/s11999-014-4033-8


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[PMID]:24664161
[Au] Autor:Rubin G; Palti R; Gurevitz S; Yaffe B
[Ad] Endereço:Hand Surgery Department, Sheba Medical Center, Tel Hashomer, Israel Faculty of Medicine, Technion, Haifa, Israel guytalr@bezeqint.net.
[Ti] Título:Free myocutaneous flap transfer to treat congenital Volkmann's contracture of the forearm.
[So] Source:J Hand Surg Eur Vol;40(6):614-9, 2015 Jul.
[Is] ISSN:2043-6289
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this study is to report our experience with free functional muscle transfer procedures for the late sequelae of the rare condition of congenital Volkmann's ischaemic contracture of the forearm. Four children, with an average age of 9.5 years (range 1.5-17), were treated and were followed for a mean of 6 years (range 1-14). Two patients had dorsal forearm contractures, and two had both flexor and extensor forearm contractures. We carried out free functional muscle transfers to replace the flexor or extensor muscles. The functional result was assessed according to the classification system of Hovius and Ultee. All patients had wrist contractures and skeletal involvement with limb length discrepancy that influenced the outcome. All five transferred muscles survived and improved the function of the hand in three of the four patients. LEVEL OF EVIDENCE 4.
[Mh] Termos MeSH primário: Antebraço
Contratura Isquêmica/congênito
Contratura Isquêmica/cirurgia
Retalho Miocutâneo
Procedimentos Cirúrgicos Reconstrutivos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Seres Humanos
Lactente
Contratura Isquêmica/fisiopatologia
Masculino
Amplitude de Movimento Articular
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150623
[Lr] Data última revisão:
150623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140326
[St] Status:MEDLINE
[do] DOI:10.1177/1753193414528850



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