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[PMID]:29465582
[Au] Autor:Wang T; Zhao G; Rui YJ; Mi JY
[Ad] Endereço:Department of Hand Surgery, Wuxi NO.9 People's Hospital Affiliated to Soochow University, Wuxi, China.
[Ti] Título:Successfully treating hand primary tuberculous synovitis by synovectomy combined antituberculous therapy: A case report.
[So] Source:Medicine (Baltimore);97(8):e9938, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Primary tuberculous infection in hand and wrist is a rare disease. Few articles reported on hand primary tuberculous synovitis. PATIENT CONCERNS: A 68-year-old Chinese male, without history of tuberculosis (TB), had complained of pain and swelling in right palm and little finger for 3 months. Patient came to our hospital on 9th Oct 2016. X-ray just showed soft tissue swelling in little finger. Magnetic resonance imaging (MRI) showed synovitis around flexor tendon of little finger, volar palm, and carpal tunnel. Notably, it also implied nodular images in little finger sizing 5 mm × 11 mm. Laboratory tests revealed C-reactive protein (CRP): 22 mg/L, erythrocyte sedimentation rate (ESR): 49 mm/h, and white blood cells (WBC): 11.8 × 10/L. DIAGNOSES: He was diagnosed with primary hand tuberculous synovitis. INTERVENTIONS: The patient received aspiration biopsy in right palm guided by ultrasound on 13rd Oct and pathological examination indicated Mycobacterium tuberculosis (MTB) infection. We performed radical synovetomy and collected abnormal tissue for pathological examination on 18th Oct. Finally, result showed MTB infection, which was the same with the result of first pathological examination. Then, this patient received antituberculous treatment. OUTCOMES: One year after operation, pain and swelling relieve and no recurrence of the clinical symptoms happened. LESSONS: Primary tuberculous synovitis of hand and wrist is rare, MTB infection should be considered as an infectious agent, especially in developing countries. Radical synovectomy and antituberculous treatment regain a satisfactory outcome.
[Mh] Termos MeSH primário: Antituberculosos/uso terapêutico
Articulação da Mão
Mycobacterium tuberculosis
Sinovectomia/métodos
Sinovite/terapia
Tuberculose Osteoarticular/terapia
Punho
[Mh] Termos MeSH secundário: Idoso
Terapia Combinada
Seres Humanos
Masculino
Sinovite/microbiologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009938


  2 / 6519 MEDLINE  
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[PMID]:29221600
[Au] Autor:Nam JL; D'Agostino MA
[Ad] Endereço:Leeds Teaching Hospitals NHS Trust and NIHR Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds LS7 4SA, UK. Electronic address: j.nam@leeds.ac.uk.
[Ti] Título:Role of ultrasound imaging in individuals at risk of RA.
[So] Source:Best Pract Res Clin Rheumatol;31(1):71-79, 2017 02.
[Is] ISSN:1532-1770
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Early diagnosis and treatment improves outcomes for patients with rheumatoid arthritis (RA). Studies have shown that musculoskeletal ultrasound is more sensitive than clinical examination in identifying synovitis. This review aims to address the role of ultrasound in identifying (1) patients with early inflammatory arthritis (IA) at risk of progression to RA and (2) those without clinical synovitis at risk of progression to early IA and therefore early RA.
[Mh] Termos MeSH primário: Artrite Reumatoide/diagnóstico por imagem
Ultrassonografia/métodos
[Mh] Termos MeSH secundário: Progressão da Doença
Diagnóstico Precoce
Seres Humanos
Sinovite/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


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[PMID]:29221756
[Au] Autor:Lesniak A; Aarnio M; Diwakarla S; Norberg T; Nyberg F; Gordh T
[Ad] Endereço:Uppsala University, Department of Pharmaceutical Biosciences, SE 751 24 Uppsala, Sweden; Medical University of Warsaw, Department of Pharmacodynamics, Centre for Preclinical Research and Technology, 02-097 Warsaw, Poland. Electronic address: anna.lesniak@wum.edu.pl.
[Ti] Título:Characterization of the binding site for d-deprenyl in human inflamed synovial membrane.
[So] Source:Life Sci;194:26-33, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: d-Deprenyl when used as a positron emission tomography tracer visualizes peripheral inflammation. The major aim of the current study was to identify and investigate the properties of the binding target for d-deprenyl in synovial membrane explants from arthritic patients. MAIN METHODS: Thirty patients diagnosed with arthritis or osteoarthritis were enrolled into the study. Homologous and competitive radioligand binding assays utilizing [ H]d-deprenyl were performed to investigate the biochemical characteristics of the binding site and assess differences in the binding profile in synovial membranes exhibiting varying levels of inflammation. KEY FINDINGS: The [ H]d-deprenyl binding assay confirmed the existence of a single, saturable population of membrane-bound protein binding sites in synovial membrane homogenates. The macroscopically determined level of inflammation correlated with an increase in [ H]d-deprenyl binding affinity, without significant alterations in binding site density. Selective monoamine oxidase B inhibitor, selegiline competed for the same site as [ H]d-deprenyl, but failed to differentiate the samples with regard to their inflammation grade. A monoamine oxidase A inhibitor, pirlindole mesylate showed only weak displacement of [ H]d-deprenyl binding. No significant alterations in monoamine oxidase B expression was detected, thus it was not confirmed whether it could serve as a marker for ongoing inflammation. SIGNIFICANCE: Our study was the first to show the biochemical characteristics of the [ H]d-deprenyl binding site in inflamed human synovium. We confirmed that d-deprenyl could differentiate between patients with varying severity of synovitis in the knee joint by binding to a protein target distinct from monoamine oxidase B.
[Mh] Termos MeSH primário: Artrite/diagnóstico
Inibidores da Monoaminoxidase/metabolismo
Monoaminoxidase/análise
Selegilina/metabolismo
Membrana Sinovial/patologia
Sinovite/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Artrite/metabolismo
Sítios de Ligação
Feminino
Seres Humanos
Masculino
Meia-Idade
Monoaminoxidase/metabolismo
Tomografia por Emissão de Pósitrons
Ensaio Radioligante
Membrana Sinovial/metabolismo
Sinovite/metabolismo
Trítio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoamine Oxidase Inhibitors); 10028-17-8 (Tritium); 2K1V7GP655 (Selegiline); EC 1.4.3.4 (Monoamine Oxidase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171210
[St] Status:MEDLINE


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[PMID]:29237438
[Au] Autor:Khansai M; Phitak T; Klangjorhor J; Udomrak S; Fanhchaksai K; Pothacharoen P; Kongtawelert P
[Ad] Endereço:Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Título:Effects of sesamin on primary human synovial fibroblasts and SW982 cell line induced by tumor necrosis factor-alpha as a synovitis-like model.
[So] Source:BMC Complement Altern Med;17(1):532, 2017 Dec 13.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic synovitis, cartilage degradation and bone deformities. Synovitis is the term for inflammation of the synovial membrane, an early stage of RA. The pathogenesis of the disease occurs through cytokine induction. The major cytokine that increases the severity of RA is TNF-α. Thus, inhibition of the TNF-α cascade is an effective way to diminish the progression of the disease. We are interested in investigating the difference between primary human synovial fibroblast (hSF) cells and SW982 as synovitis models induced by TNF-α and in monitoring their responses to sesamin as an anti-inflammatory phytochemical. METHOD: The designed experiments were performed in hSF cells or the SW982 cell line treated with 10 ng/ml TNF-α with or without 0.25, 0.5 or 1 µM sesamin. Subsequently, pro-inflammatory cytokine genes and proteins were measured in parallel with a study of associated signalling transduction involved in inflammatory processes, including NF-κB and MAPK pathways. RESULTS: The results demonstrated that although hSF and SW982 cells responded to TNF-α induction in the same fashion, they reacted at different levels. TNF-α could induce IL-6, IL-8 and IL-1ß in both cell types, but the levels in SW982 cells were much higher than in hSF cells. This characteristic was due to the different induction of MAPKs in each cell type. Both cell types reacted to sesamin in almost the same fashion. However, hSF cells were more sensitive to sesamin than SW982 cells in terms of the anti-RA effect. CONCLUSIONS: The responses of TNF-α-induced hSF and SW982 were different at the signal transduction level. However, the two cell types showed almost the same reaction to sesamin treatment in terms of the end point of the response.
[Mh] Termos MeSH primário: Dioxóis/farmacologia
Fibroblastos/efeitos dos fármacos
Lignanas/farmacologia
Membrana Sinovial/citologia
Sinovite/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Mh] Termos MeSH secundário: Artrite Reumatoide
Linhagem Celular
Citocinas/metabolismo
Seres Humanos
Modelos Biológicos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Dioxoles); 0 (Lignans); 0 (Tumor Necrosis Factor-alpha); S7946O4P76 (sesamin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2035-2


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[PMID]:28747638
[Au] Autor:Hong SS; Marotte H; Courbon G; Firestein GS; Boulanger P; Miossec P
[Ad] Endereço:University of Lyon, Lyon, 69007, France. saw-see.hong@univ-lyon1.fr.
[Ti] Título:PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints.
[So] Source:Nat Commun;8(1):146, 2017 07 27.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In rheumatoid arthritis (RA), the proliferation of fibroblast-like synoviocytes (FLS) is the cause of chronic inflammation in joints and of joint damage. Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficiency is hampered by low transduction, as FLS do not express HAdV5 receptors on the cell surface. Here we show that efficient transduction of PUMA in FLS can be achieved by conjugating HAdV5 to a baculovirus, which binds to the cell surface via the envelope glycoprotein Gp64. Intra-articular injection in an adjuvant-induced rat model of RA induces apoptosis of FLS, leading to significant decrease in joint inflammation, joint damage, and bone loss with improvement in joint function and mobility. Our results demonstrate the therapeutic potential of PUMA gene therapy as a local treatment in various forms of arthritis in which abnormal FLS proliferation is implicated.Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.
[Mh] Termos MeSH primário: Proteínas Reguladoras de Apoptose/genética
Artrite Reumatoide/genética
Proteínas Proto-Oncogênicas/genética
Sinoviócitos/metabolismo
Sinovite/genética
[Mh] Termos MeSH secundário: Adenovírus Humanos/genética
Animais
Apoptose/genética
Proteínas Reguladoras de Apoptose/metabolismo
Artrite Experimental/genética
Artrite Experimental/metabolismo
Artrite Experimental/terapia
Artrite Reumatoide/terapia
Baculoviridae/genética
Proliferação Celular/genética
Células Cultivadas
Feminino
Técnicas de Transferência de Genes
Terapia Genética/métodos
Vetores Genéticos/genética
Células HEK293
Seres Humanos
Proteínas Proto-Oncogênicas/metabolismo
Ratos Endogâmicos Lew
Sinovite/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Apoptosis Regulatory Proteins); 0 (BBC3 protein, human); 0 (Proto-Oncogene Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-00142-1


  6 / 6519 MEDLINE  
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[PMID]:28954874
[Au] Autor:Merlin E; Breton S; Fraitag S; Stéphan JL; Wouters C; Bodemer C; Bader-Meunier B
[Ad] Endereço:Inserm CIC 1405, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France.
[Ti] Título:Fibrous Arthropathy Associated With Morphea: A New Cause of Diffuse Acquired Joint Contractures.
[So] Source:Pediatrics;140(4), 2017 Oct.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Etiologies for childhood-onset diffuse joint contractures encompass a large group of inherited disorders and acquired diseases, in particular a subtype of juvenile idiopathic arthritis called "dry polyarthritis," dermatomyositis, and systemic sclerosis. We report on 2 boys, aged 5 and 8 years, who developed acquired symmetric painless joint contractures preceding the development of superficial plaques of morphea by 7 to 13 months. There was no other clinical involvement, biological inflammation, or autoantibodies. No urinary mucopolysaccharidosis was seen. In both patients, wrist MRI showed no joint effusion, no bone erosion, and no or mild synovial thickening with slight enhancement after gadolinium infusion. One patient underwent a synovial biopsy, which showed dense fibrosis with a sparse inflammatory infiltrate, similar to the pathologic pattern observed in the skin biopsy. With methotrexate and systemic steroids, joint contractures slowly improved in the first patient and remained stable in the second. These 2 cases suggest that fibrous synovitis should be considered in children with acquired diffuse, symmetric, painless contractures and without elevation of acute-phase reactants, even in the absence of cutaneous manifestations. Articular MRI with gadolinium and careful cutaneous examination at onset and during follow-up should provide clues for diagnosing this entity.
[Mh] Termos MeSH primário: Artrite Juvenil/diagnóstico
Contratura/etiologia
Esclerodermia Localizada/diagnóstico
Sinovite/diagnóstico
[Mh] Termos MeSH secundário: Artrite Juvenil/complicações
Artrite Juvenil/patologia
Biópsia
Criança
Pré-Escolar
Fibrose
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Esclerodermia Localizada/complicações
Esclerodermia Localizada/patologia
Sinovite/complicações
Sinovite/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE


  7 / 6519 MEDLINE  
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[PMID]:28793332
[Au] Autor:Choi IY; Karpus ON; Turner JD; Hardie D; Marshall JL; de Hair MJH; Maijer KI; Tak PP; Raza K; Hamann J; Buckley CD; Gerlag DM; Filer A
[Ad] Endereço:Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
[Ti] Título:Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis.
[So] Source:PLoS One;12(8):e0182751, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Previous studies have shown increased expression of stromal markers in synovial tissue (ST) of patients with established rheumatoid arthritis (RA). Here, ST expression of stromal markers in early arthritis in relationship to diagnosis and prognostic outcome was studied. METHODS: ST from 56 patients included in two different early arthritis cohorts and 7 non-inflammatory controls was analysed using immunofluorescence to detect stromal markers CD55, CD248, fibroblast activation protein (FAP) and podoplanin. Diagnostic classification (gout, psoriatic arthritis, unclassified arthritis (UA), parvovirus associated arthritis, reactive arthritis and RA), disease outcome (resolving vs persistent) and clinical variables were determined at baseline and after follow-up, and related to the expression of stromal markers. RESULTS: We observed expression of all stromal markers in ST of early arthritis patients, independent of diagnosis or prognostic outcome. Synovial expression of FAP was significantly higher in patients developing early RA compared to other diagnostic groups and non-inflammatory controls. In RA FAP protein was expressed in both lining and sublining layers. Podoplanin expression was higher in all early inflammatory arthritis patients than controls, but did not differentiate diagnostic outcomes. Stromal marker expression was not associated with prognostic outcomes of disease persistence or resolution. There was no association with clinical or sonographic variables. CONCLUSIONS: Stromal cell markers CD55, CD248, FAP and podoplanin are expressed in ST in the earliest stage of arthritis. Baseline expression of FAP is higher in early synovitis patients who fulfil classification criteria for RA over time. These results suggest that significant fibroblast activation occurs in RA in the early window of disease.
[Mh] Termos MeSH primário: Artrite/metabolismo
Células Estromais/metabolismo
Membrana Sinovial/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Antígenos CD/metabolismo
Antígenos de Neoplasias/metabolismo
Artrite/diagnóstico
Biomarcadores/metabolismo
Antígenos CD55/metabolismo
Progressão da Doença
Feminino
Fibroblastos/metabolismo
Gelatinases/metabolismo
Seres Humanos
Masculino
Glicoproteínas de Membrana/metabolismo
Proteínas de Membrana/metabolismo
Meia-Idade
Prognóstico
Serina Endopeptidases/metabolismo
Sinovite/diagnóstico
Sinovite/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, Neoplasm); 0 (Biomarkers); 0 (CD248 protein, human); 0 (CD55 Antigens); 0 (Membrane Glycoproteins); 0 (Membrane Proteins); 0 (PDPN protein, human); EC 3.4.21.- (Serine Endopeptidases); EC 3.4.21.- (fibroblast activation protein alpha); EC 3.4.24.- (Gelatinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182751


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[PMID]:28777663
[Au] Autor:Li AE; Johnson CC; Sneag DB; Koch CN; Fields K; Miller TT; Wright TM; Padgett DE; Potter HG
[Ad] Endereço:1 Department of Radiology and Imaging, Hospital for Special Surgery, 535 E 70th St, New York, NY 10021.
[Ti] Título:Frondlike Synovitis on MRI and Correlation With Polyethylene Surface Damage of Total Knee Arthroplasty.
[So] Source:AJR Am J Roentgenol;209(4):W231-W237, 2017 Oct.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The purpose of this study is to determine the association between polyethylene surface damage and the severity of frondlike hypertrophied synovitis, joint distention, capsular thickness, and osteolysis on MRI compared with other patient factors. Another goal of this study is to ascertain the interobserver reliability in MRI evaluation of synovitis. MATERIALS AND METHODS: MR images of 61 patients who had undergone revision total knee arthroplasty (TKA) were retrospectively reviewed. The two MRI reviewers were blinded to clinical and retrieval data. The retrieved polyethylene tibial inserts were graded to determine the severity of surface damage. The association of MRI features with surface damage was assessed using Spearman correlation coefficients and multiple linear regression. Interobserver reliability was assessed using the kappa statistic. RESULTS: Correlations were moderate between the surface damage score and MRI synovitis severity (r = 0.46; p < 0.001) and joint distention (r = 0.41; p = 0.001). Multiple linear regression showed that the MRI synovitis score (p = 0.045), male sex (p = 0.007), body mass index (p = 0.041), and the time since implantation (p < 0.0001) predicted the surface damage score. Substantial interobserver agreement was shown for MRI grading of synovitis (κ = 0.72; 95% CI, 0.65-0.80). CONCLUSION: The magnitude of frondlike hypertrophied synovitis on MRI is significantly associated with polyethylene surface damage in patients who undergo revision TKA. The finding of severe frondlike synovitis on MR images of patients with TKA should raise the possibility of polyethylene surface damage. However, time since implantation is a stronger predictor of surface damage.
[Mh] Termos MeSH primário: Prótese do Joelho
Imagem por Ressonância Magnética
Polietileno
Complicações Pós-Operatórias/diagnóstico por imagem
Complicações Pós-Operatórias/etiologia
Falha de Prótese
Sinovite/diagnóstico por imagem
Sinovite/etiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Artroplastia do Joelho
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9002-88-4 (Polyethylene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.16.17443


  9 / 6519 MEDLINE  
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[PMID]:28631701
[Au] Autor:Vasilyeva LV; Lakhin DI
[Ad] Endereço:N.N. Burdenko Voronezh State Medical University, Ministry of Health of Russia, Voronezh, Russia.
[Ti] Título:[Clinical features of osteoarthritis in patients with metabolic syndrome].
[Ti] Título:Osobennosti klinicheskoi kartiny osteoartroza u patsientov s metabolicheskim sindromom..
[So] Source:Ter Arkh;89(5):65-68, 2017.
[Is] ISSN:0040-3660
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To estimate clinical and laboratory parameters in patients with osteoarthritis (OA) and in those with OA and metabolic syndrome (MS). SUBJECTS AND METHODS: 164 patients with OA were examined and divided into 2 groups of 82 people: a study group (patients with MS) and a control one (those without MS). OA was defined according to the diagnostic criteria described by R.D. Althmann (1995). MS was identified based on the criteria developed by the International Diabetes Federation (2005). The location of affected and swollen joints was determined according to the Richie index; the intensity of pain syndrome was measured by a visual analogue scale at rest and on movement; the WOMAC and Lequesne indexes were estimated in the patients. Erythrocyte sedimentation rate and C-reactive protein and tumor necrosis factor-α levels were determined from laboratory data. RESULTS: In the MS group, the frequency of joint injuries at various sites, the prevalence of synovitis, and the intensity of pain and inflammation were significantly higher than in the non-MS group. CONCLUSION: The negative impact of MS on the clinical picture of OA can be inferred by the findings.
[Mh] Termos MeSH primário: Articulação do Joelho/diagnóstico por imagem
Síndrome Metabólica
Osteoartrite
[Mh] Termos MeSH secundário: Idoso
Artralgia/diagnóstico
Sedimentação Sanguínea
Proteína C-Reativa/análise
Comorbidade
Feminino
Seres Humanos
Masculino
Síndrome Metabólica/sangue
Síndrome Metabólica/diagnóstico
Síndrome Metabólica/epidemiologia
Síndrome Metabólica/fisiopatologia
Meia-Idade
Osteoartrite/sangue
Osteoartrite/diagnóstico
Osteoartrite/epidemiologia
Osteoartrite/fisiopatologia
Medição da Dor/métodos
Prevalência
Estudos Retrospectivos
Federação Russa/epidemiologia
Estatística como Assunto
Avaliação de Sintomas
Sinovite/diagnóstico
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tumor Necrosis Factor-alpha); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.17116/terarkh201789565-68


  10 / 6519 MEDLINE  
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[PMID]:28611080
[Au] Autor:Glinatsi D; Baker JF; Hetland ML; Hørslev-Petersen K; Ejbjerg BJ; Stengaard-Pedersen K; Junker P; Ellingsen T; Lindegaard HM; Hansen I; Lottenburger T; Møller JM; Ørnbjerg L; Vestergaard A; Jurik AG; Thomsen HS; Torfing T; Møller-Bisgaard S; Axelsen MB; Østergaard M
[Ad] Endereço:Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Glostrup, Denmark.
[Ti] Título:Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: longitudinal results from two randomised controlled trials.
[So] Source:Ann Rheum Dis;76(10):1707-1715, 2017 Oct.
[Is] ISSN:1468-2060
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS: Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up. These features, and changes therein, were assessed for associations with health assessment questionnaires (HAQ), patient global visual analogue scales (VAS-PtGlobal) and VAS-pain using Spearman's correlations, generalised estimating equations and univariate/multivariable linear regression analyses. MRI features were further tested for trends against specific hand-related HAQ items using Jonckheere trend tests. RESULTS: MRI inflammation, but not damage, showed statistically significant associations with HAQ, VAS-PtGlobal and VAS-pain for status and change scores, independently of C reactive protein and swollen joint count. MRI-assessed synovitis was most consistently associated with PROs, particularly VAS-PtGlobal and VAS-pain. MRI-assessed synovitis and tenosynovitis mean scores were positively associated with patient-reported difficulty to cut meat and open a milk carton (p<0.01), and similar patterns were seen for other hand-related HAQ items. Incorporating metacarpophalangeal joints in the analyses did not strengthen the associations between MRI pathology and PROs. CONCLUSIONS: MRI-assessed inflammation, but not damage, in early RA wrists is associated with patient-reported physical impairment, global assessment of disease activity and pain and influences the physical function in the hand. TRIAL REGISTRATION NUMBER: NCT00660647.
[Mh] Termos MeSH primário: Artrite Reumatoide/diagnóstico por imagem
Inflamação/diagnóstico por imagem
Imagem por Ressonância Magnética
Articulação do Punho/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Artrite Reumatoide/sangue
Artrite Reumatoide/tratamento farmacológico
Proteína C-Reativa/metabolismo
Método Duplo-Cego
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Inflamação/sangue
Estudos Longitudinais
Masculino
Articulação Metacarpofalângica/diagnóstico por imagem
Meia-Idade
Dor Musculoesquelética/diagnóstico por imagem
Osteíte/sangue
Osteíte/diagnóstico por imagem
Medição da Dor
Medidas de Resultados Relatados pelo Paciente
Radiografia
Índice de Gravidade de Doença
Sinovite/sangue
Sinovite/diagnóstico por imagem
Tenossinovite/sangue
Tenossinovite/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1136/annrheumdis-2017-211315



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