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[PMID]:29310369
[Au] Autor:Lv ZY; Xu XM; Cao XF; Wang Q; Sun DF; Tian WJ; Yang Y; Wang YZ; Hao YL
[Ad] Endereço:Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong, People's Republic of China.
[Ti] Título:Mitochondrial mutations in 12S rRNA and 16S rRNA presenting as chronic progressive external ophthalmoplegia (CPEO) plus: A case report.
[So] Source:Medicine (Baltimore);96(48):e8869, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Chronic progressive external ophthalmoplegia (CPEO) is a classical mitochondrial ocular disorder characterized by bilateral progressive ptosis and ophthalmoplegia. Kearns -Sayre syndrome (KSS) is a multisystem disorder with PEO, cardiac conduction block, and pigmentary retinopathy. A few individuals with CPEO have other manifestations of KSS, but do not meet all the clinical diagnosis criteria, and this is called "CPEO plus." PATIENT CONCERNS: We report a 48-year-old woman exhibiting limb weakness, ptosis, ophthalmoparesis, and cerebellar dysfunctions. DIAGNOSES: The patient was diagnosed as exhibiting CPEO plus syndrome. INTERVENTIONS: The patient underwent clinical, genetic, histological, and histochemical analysis. She was treated orally with CoQ10, vitamin Bs, L-carnitine, and vitamin E. OUTCOMES: The patient's serum creatine kinase levels, electrocardiography, and nerve conduction study results were normal; an electromyogram revealed myopathic findings. Magnetic resonance imaging showed global brain atrophy, particularly in the brainstem and cerebellum areas. A muscle biopsy showed the presence of abundant ragged red fibers. Sequencing of the mitochondrial DNA from the skeletal muscle biopsy revealed C960del mutation in 12S rRNA and homozygous mutation C2835T in 16S rRNA. She took medicines on schedule, the clinical features were similar as 2 years ago. LESSONS: This is the first report of 2 rRNA mutations in a patient with MRI findings showing global brain atrophy, particularly in brainstem and cerebellum areas. Early recognition and appropriate treatment is crucial. This case highlights the cerebellar ataxia can occur in CPEO plus.
[Mh] Termos MeSH primário: Oftalmoplegia Externa Progressiva Crônica/genética
RNA Ribossômico 16S/genética
RNA Ribossômico/genética
RNA/análise
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Imagem por Ressonância Magnética
Meia-Idade
Mutação
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal); 0 (RNA, Ribosomal, 16S); 0 (RNA, mitochondrial); 0 (RNA, ribosomal, 12S); 63231-63-0 (RNA)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008869


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[PMID]:28535487
[Au] Autor:Gueguen A; Jardel C; Polivka M; Tan SV; Gray F; Vignal C; Lombès A; Gout O; Bostock H
[Ad] Endereço:Department of Neurology, Fondation Ophtalmologique A. de Rothschild, Paris, France.
[Ti] Título:Nerve excitability changes related to muscle weakness in chronic progressive external ophthalmoplegia.
[So] Source:Clin Neurophysiol;128(7):1258-1263, 2017 Jul.
[Is] ISSN:1872-8952
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To explore potential spreading to peripheral nerves of the mitochondrial dysfunction in chronic progressive external ophthalmoplegia (CPEO) by assessing axonal excitability. METHODS: CPEO patients (n=13) with large size deletion of mitochondrial DNA and matching healthy controls (n=22) were included in a case-control study. Muscle strength was quantified using MRC sum-score and used to define two groups of patients: CPEO-weak and CPEO-normal (normal strength). Nerve excitability properties of median motor axons were assessed with the TROND protocol and changes interpreted with the aid of a model. RESULTS: Alterations of nerve excitability strongly correlated with scores of muscle strength. CPEO-weak displayed abnormal nerve excitability compared to CPEO-normal and healthy controls, with increased superexcitability and responses to hyperpolarizing current. Modeling indicated that the CPEO-weak recordings were best explained by an increase in the 'Barrett-Barrett' conductance across the myelin sheath. CONCLUSION: CPEO patients with skeletal weakness presented sub-clinical nerve excitability changes, which were not consistent with axonal membrane depolarization, but suggested Schwann cell involvement. SIGNIFICANCE: This study provides new insights into the spreading of large size deletion of mitochondrial DNA to Schwann cells in CPEO patients.
[Mh] Termos MeSH primário: Debilidade Muscular/diagnóstico
Debilidade Muscular/fisiopatologia
Condução Nervosa/fisiologia
Oftalmoplegia Externa Progressiva Crônica/diagnóstico
Oftalmoplegia Externa Progressiva Crônica/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
DNA Mitocondrial/genética
Feminino
Seres Humanos
Masculino
Meia-Idade
Debilidade Muscular/genética
Oftalmoplegia Externa Progressiva Crônica/genética
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


  3 / 476 MEDLINE  
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[PMID]:28430993
[Au] Autor:Siibak T; Clemente P; Bratic A; Bruhn H; Kauppila TES; Macao B; Schober FA; Lesko N; Wibom R; Naess K; Nennesmo I; Wedell A; Peter B; Freyer C; Falkenberg M; Wredenberg A
[Ad] Endereço:Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg SE-405?30, Sweden.
[Ti] Título:A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma.
[So] Source:Hum Mol Genet;26(13):2515-2525, 2017 Jul 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mutations in the mitochondrial DNA polymerase, POLG, are associated with a variety of clinical presentations, ranging from early onset fatal brain disease in Alpers syndrome to chronic progressive external ophthalmoplegia. The majority of mutations are linked with disturbances of mitochondrial DNA (mtDNA) integrity and maintenance. On a molecular level, depending on their location within the enzyme, mutations either lead to mtDNA depletion or the accumulation of multiple mtDNA deletions, and in some cases these molecular changes can be correlated to the clinical presentation. We identified a patient with a dominant p.Y955H mutation in POLG, presenting with a severe, early-onset multi-systemic mitochondrial disease with bilateral sensorineural hearing loss, cataract, myopathy, and liver failure. Using a combination of disease models of Drosophila melanogaster and in vitro biochemistry analysis, we compare the molecular consequences of the p.Y955H mutation to the well-documented p.Y955C mutation. We demonstrate that both mutations affect mtDNA replication and display a dominant negative effect, with the p.Y955H allele resulting in a more severe polymerase dysfunction.
[Mh] Termos MeSH primário: DNA Polimerase Dirigida por DNA/genética
DNA Polimerase Dirigida por DNA/metabolismo
[Mh] Termos MeSH secundário: Adulto
Sequência de Aminoácidos
Animais
DNA Polimerase gama
Replicação do DNA/genética
DNA Mitocondrial/genética
Modelos Animais de Doenças
Drosophila melanogaster/genética
Feminino
Seres Humanos
Lactente
Mitocôndrias/genética
Mutação/genética
Oftalmoplegia Externa Progressiva Crônica/enzimologia
Linhagem
Fenótipo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); EC 2.7.7.7 (DNA Polymerase gamma); EC 2.7.7.7 (DNA-Directed DNA Polymerase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx146


  4 / 476 MEDLINE  
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[PMID]:28359601
[Au] Autor:Hsiao CC; Lee NC; Lin CW; Tsai TH
[Ad] Endereço:Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.
[Ti] Título:Reply to: "Peculiarities of progressive external ophthalmoplegia due to single mtDNA deletions".
[So] Source:J Formos Med Assoc;116(10):821-822, 2017 10.
[Is] ISSN:0929-6646
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Mh] Termos MeSH primário: DNA Mitocondrial/genética
Oftalmoplegia Externa Progressiva Crônica/genética
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


  5 / 476 MEDLINE  
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[PMID]:28128857
[Au] Autor:Cruz S; Taipa R; Nogueira C; Pereira C; Almeida LS; Neiva R; Geraldes T; Guimarães A; Melo-Pires M; Vilarinho L
[Ad] Endereço:Neurology Department, Hospital Prof. Doutor Fernando Fonseca, IC 19, 2720-276, Amadora, Portugal.
[Ti] Título:Clinical, biochemical, molecular, and histological features of 65 Portuguese patients with mitochondrial disorders.
[So] Source:Muscle Nerve;56(5):868-872, 2017 Nov.
[Is] ISSN:1097-4598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Mitochondrial disorders display remarkable genetic and phenotypic heterogeneity. METHODS: We performed a retrospective analysis of the clinical, histological, biochemical, and genetic features of 65 patients with molecular diagnoses of mitochondrial disorders. RESULTS: The most common genetic diagnosis was a single large-scale mitochondrial DNA (mtDNA) deletion (41.5%), and the most frequent clinical phenotype was chronic progressive external ophthalmoplegia (CPEO). It occurred in 41.5% of all patients, primarily in those with mtDNA deletions. Histological signs of mitochondrial dysfunction were found in 73.8% of patients, and respiratory chain enzyme assay (RCEA) abnormalities were detected in 51.9%. CONCLUSIONS: This study confirms the high relative frequency of single large-scale deletions among mitochondrial disorders as well as its particular association with CPEO. Muscle histology seems to be particularly useful in older patients and those with mtDNA deletions, whereas RCEA might be more helpful in young children or individuals with mtDNA depletion. Muscle Nerve 56: 868-872, 2017.
[Mh] Termos MeSH primário: DNA Mitocondrial/genética
Doenças Mitocondriais
Complexos Multienzimáticos/genética
Complexos Multienzimáticos/metabolismo
Músculo Esquelético/patologia
Deleção de Sequência/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Estudos de Coortes
Análise Mutacional de DNA
Feminino
Seres Humanos
Lactente
Masculino
Meia-Idade
Doenças Mitocondriais/genética
Doenças Mitocondriais/metabolismo
Doenças Mitocondriais/patologia
Oftalmoplegia Externa Progressiva Crônica/genética
Portugal
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial); 0 (Multienzyme Complexes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1002/mus.25593


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[PMID]:27856367
[Au] Autor:Hedermann G; Løkken N; Dahlqvist JR; Vissing J
[Ad] Endereço:Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: hedermann@gmail.com.
[Ti] Título:Dysphagia is prevalent in patients with CPEO and single, large-scale deletions in mtDNA.
[So] Source:Mitochondrion;32:27-30, 2017 Jan.
[Is] ISSN:1872-8278
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to assess the frequency of subjective and objective dysphagia in patients with chronic progressive external ophthalmoplegia (CPEO) due to single, large-scale deletions (LSDs) of mitochondrial DNA (mtDNA). METHODS: Sixteen patients with CPEO and single LSDs of mtDNA were included in the study and compared to a control group of 12 patients with the m.3243A>G mtDNA mutation. Patients had to drink 80ml of water at 4°C as fast as they could (cold-water test) and fill out a standardized questionnaire about dysphagia. RESULTS: Eight patients (50%) with CPEO and single LSDs of mtDNA had a prolonged cold-water test, including one with a PEG-tube, who was unable to perform the test, and nine patients reported subjective swallowing problems (56.3%). All mitochondrial myopathy patients in the control group had a normal duration of the cold-water test. CONCLUSIONS: The study shows that dysphagia is a common problem in patients with CPEO and LSDs of mtDNA. Dysphagia seems to be progressive with age as abnormal swallowing occurred preferentially in persons ≥45years. The study shows that increased awareness of this symptom should be given to address appropriate treatment interventions and avoid complications such as social isolation, malnutrition and aspiration pneumonia.
[Mh] Termos MeSH primário: Transtornos de Deglutição/etiologia
Miopatias Mitocondriais/complicações
Miopatias Mitocondriais/patologia
Oftalmoplegia Externa Progressiva Crônica/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Transversais
DNA Mitocondrial/genética
Feminino
Seres Humanos
Masculino
Meia-Idade
Músculos/patologia
Deleção de Sequência
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


  7 / 476 MEDLINE  
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[PMID]:27749773
[Au] Autor:Mendes Marques NBPS; Barros SR; Miranda AF; Nobre Cardoso J; Parreira S; Fonseca T; Donaire NM; Campos N
[Ad] Endereço:Garcia de Orta Hospital, Almada, Portugal.
[Ti] Título:Horizontal Gaze Palsy and Progressive Scoliosis With ROBO 3 Mutations in Patients From Cape Verde.
[So] Source:J Neuroophthalmol;37(2):162-165, 2017 Jun.
[Is] ISSN:1536-5166
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare and autosomal recessive syndrome. We describe 2 cases of HGPPS which are the first documented in patients of African ancestry from an isolated population in Cape Verde. They demonstrated typical findings on neuro-ophthalmic examination and brain magnetic resonance imaging. One patient had novel heterozymous mutations of the ROB0 3 gene.
[Mh] Termos MeSH primário: Tronco Encefálico/patologia
DNA/genética
Mutação
Transtornos da Motilidade Ocular/etiologia
Oftalmoplegia Externa Progressiva Crônica/complicações
Receptores Imunológicos/genética
Escoliose/complicações
[Mh] Termos MeSH secundário: Adolescente
Cabo Verde
Criança
Análise Mutacional de DNA
Progressão da Doença
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Proteínas do Tecido Nervoso
Transtornos da Motilidade Ocular/diagnóstico
Transtornos da Motilidade Ocular/fisiopatologia
Oftalmoplegia Externa Progressiva Crônica/diagnóstico
Linhagem
Receptores Imunológicos/metabolismo
Escoliose/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nerve Tissue Proteins); 0 (ROBO3 protein, human); 0 (Receptors, Immunologic); 9007-49-2 (DNA)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE
[do] DOI:10.1097/WNO.0000000000000455


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[PMID]:27029465
[Au] Autor:Zhu CC; Traboulsi EI; Parikh S
[Ad] Endereço:a Cleveland Clinic , Center for Pediatric Neurology , Cleveland , Ohio , USA.
[Ti] Título:Ophthalmological findings in 74 patients with mitochondrial disease.
[So] Source:Ophthalmic Genet;38(1):67-69, 2017 Jan-Feb.
[Is] ISSN:1744-5094
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mitochondrial disease often manifests with ophthalmologic signs and symptoms. Due to the important role of mitochondria in aerobic metabolism, the eyes are among the more preferentially involved organs. The clinical diagnosis of mitochondrial disease can be facilitated by an improved knowledge of the types and magnitude of their various manifestations. The aim of this study was to describe the ophthalmological manifestations of patients with mitochondrial diseases that are currently not well elucidated. METHODS: From a database of patients with verified primary mitochondrial disease (n = 81) who had visited our institution we identified 74 patients who had ophthalmologic examinations. Demographic, clinical, and ophthalmologic data were collected. Institutional review board approval was obtained. RESULTS: A total of 74 patients were identified with Leigh disease, MELAS, MERRF, CPEO, Pearson/Kearns-Sayre syndrome, as well as other mtDNA point mutations, deletions, depletions, and mutations. Overall, 26 of the 74 patients (35%) had one or more ophthalmological abnormalities. Retinal pigmentary changes were present in 12/74 (16%) of patients. Partial or total optic atrophy (OA) was noted in 8/74 (10%) of patients. Decreased extra-ocular movement (EOM) was noted in 6/74 (8%) of patients. Other ophthalmological findings included macular atrophy (2/74), macular dystrophy (1/74), and visual field defects (1/74). CONCLUSIONS: Over one-third of our cohort of patients with mitochondrial disorders had ophthalmological manifestations, some of which affected vision significantly. Eye examinations are critical in patients with mitochondrial disease so that complete assessments of the effects of the underlying mutations are uncovered and the appropriate counseling and care are given.
[Mh] Termos MeSH primário: Oftalmopatias/diagnóstico
Doenças Mitocondriais/diagnóstico
[Mh] Termos MeSH secundário: Adulto
DNA Mitocondrial/genética
Oftalmopatias/genética
Feminino
Seres Humanos
Síndrome de Kearns-Sayre/diagnóstico
Síndrome de Kearns-Sayre/genética
Doença de Leigh/diagnóstico
Doença de Leigh/genética
Síndrome MELAS/diagnóstico
Síndrome MELAS/genética
Síndrome MERRF/diagnóstico
Síndrome MERRF/genética
Masculino
Doenças Mitocondriais/genética
Oftalmoplegia Externa Progressiva Crônica/diagnóstico
Oftalmoplegia Externa Progressiva Crônica/genética
Mutação Puntual
Estudos Retrospectivos
Deleção de Sequência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.3109/13816810.2015.1130153


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[PMID]:27814938
[Au] Autor:Finsterer J; Zarrouk-Mahjoub S
[Ad] Endereço:Krankenanstalt Rudolfstiftung, Vienna, Austria. Electronic address: fipaps@yahoo.de.
[Ti] Título:Peculiarities of progressive external ophthalmoplegia due to single mitochondrial DNA deletions.
[So] Source:J Formos Med Assoc;115(12):1099-1100, 2016 12.
[Is] ISSN:0929-6646
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Mh] Termos MeSH primário: DNA Mitocondrial/genética
Oftalmoplegia Externa Progressiva Crônica/genética
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (DNA, Mitochondrial)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161106
[St] Status:MEDLINE


  10 / 476 MEDLINE  
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[PMID]:27541941
[Au] Autor:Vemuri S; Christianson MD; Demirci H
[Ad] Endereço:a Department of Ophthalmology , Henry Ford Hospital , Detroit , Michigan , USA.
[Ti] Título:Correcting myogenic ptosis accompanying extraocular muscle weakness: The "Bobby Pin" procedure.
[So] Source:Orbit;35(5):267-70, 2016 Oct.
[Is] ISSN:1744-5108
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This article evaluates the "Bobby Pin" procedure in the correction of myogenic ptosis accompanying extraocular muscle weakness. We retrospectively reviewed 26 eyelids of 13 patients who underwent "Bobby Pin" procedure for myogenic ptosis accompanying extraocular muscle weakness. We evaluated the patients' clinical features such as age, etiology of ptosis, symptoms, standard ptosis measurements, associated systemic diseases, additional ophthalmic conditions, complications, and recurrence. Etiology of myogenic ptosis and extraocular muscle weakness was oculopharyngeal dystrophy in 4 (31%) patients, chronic progressive external ophthalmoplegia in 4 (31%) patients, myotonic dystrophy in 2 (23%) patients, and idiopathic in 3 (15%) patients. The mean levator function was approximately 5 mm pre- and post-operatively (range 1 to 12 mm). The mean margin-to-reflex distance 1 increased from -1.1 mm (below the light reflex) pre-operatively to +0.4 mm (above the light reflex) post-operatively. After a mean follow-up of 40 months, only 1 (8%) patient experienced ptosis recurrence. Upper eyelids were symmetric in both contour and height in all patients. Mild superficial keratopathy involving less than 10% of cornea was observed in 4 (31%) patients. The "Bobby Pin" procedure is an effective and long-lasting treatment option for correcting acquired ptosis accompanying extraocular muscle weakness. The procedure is safe, simple, easily learned, time- and cost-effective, and does not require any expensive equipment.
[Mh] Termos MeSH primário: Blefaroptose/cirurgia
Debilidade Muscular/cirurgia
Músculos Oculomotores/cirurgia
Procedimentos Cirúrgicos Oftalmológicos
[Mh] Termos MeSH secundário: Adulto
Idoso
Blefaroptose/etiologia
Doenças da Córnea/complicações
Feminino
Seres Humanos
Masculino
Meia-Idade
Debilidade Muscular/etiologia
Distrofia Muscular Oculofaríngea/complicações
Distrofia Miotônica/complicações
Músculos Oculomotores/patologia
Oftalmoplegia Externa Progressiva Crônica/complicações
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170209
[Lr] Data última revisão:
170209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE
[do] DOI:10.1080/01676830.2016.1193528



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