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[PMID]:29267668
[Au] Autor:Costa SAP; Florezi GP; Artes GE; Costa JRD; Gallo RT; Freitas PM; Witzel AL
[Ad] Endereço:Universidade de São Paulo, School of Dentistry, Department of Stomatology, São Paulo, SP, Brazil.
[Ti] Título:The analgesic effect of photobiomodulation therapy (830 nm) on the masticatory muscles: a randomized, double-blind study.
[So] Source:Braz Oral Res;31:e107, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:This study assesses the efficacy of photobiomodulation therapy (830 nm) for myalgia treatment of masticatory muscles. Sixty patients with muscular myalgia were selected and randomly allocated into 2 groups (n=30): Group A comprised patients given a placebo (control), and Group B consisted of those undergoing photobiomodulation therapy (PBMT). PBMT and placebo were applied bilaterally to specific points on the masseter and temporal muscles. Referred pain elicited by palpation and maximum mouth opening were measured before (EV1) and after (EV2) the treatments. The data were analyzed using statistical tests, considering a significance level of 5%. No significant differences in range were observed for active or passive mouth opening (p ≥ 0.05). Comparing the final outcomes (EV1-EV2) of both treatments, statistical significance was verified for total pain in the right masseter muscle (p = 0.001) and total pain (p = 0.005). In EV2, significant differences in pain reported with palpation were found between Groups A and B for the following: left posterior temporal muscle (p = 0.025), left superior masseter muscle (p = 0.036), inferior masseter muscle (p = 0.021), total pain (left side) (p = 0.009), total masseter muscle (left side) (p = 0.014), total temporal (left side) (p = 0.024), and total pain (p = 0.035). We concluded that PBMT (830 nm) reduces pain in algic points, but does not influence the extent of mouth opening in patients with myalgia.
[Mh] Termos MeSH primário: Terapia com Luz de Baixa Intensidade/métodos
Músculo Masseter/efeitos da radiação
Mialgia/radioterapia
Músculo Temporal/efeitos da radiação
Transtornos da Articulação Temporomandibular/radioterapia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Dor Crônica/radioterapia
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
Dose de Radiação
Valores de Referência
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:28456527
[Au] Autor:Perry J; Towers CV; Weitz B; Wolfe L
[Ad] Endereço:Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, University of Tennessee Medical Center, Knoxville, TN, United States.
[Ti] Título:Patient reaction to Tdap vaccination in pregnancy.
[So] Source:Vaccine;35(23):3064-3066, 2017 05 25.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The current obstetrical recommendation is to routinely administer the tetanus, diphtheria, and acellular pertussis (Tdap) vaccination during every pregnancy regardless of a patient's prior history. There are minimal data that have prospectively evaluated solicited patient response to this treatment plan. The study objective was to evaluate patient reaction following receipt of Tdap vaccination during pregnancy. METHODS: This was a prospective observational study conducted from May 2014 through March 2016. The study design involved solicited patient reaction within 1-7days after the administration of the Tdap vaccine. Data collected included pain or soreness, swelling, and/or redness at the injection site, as well as, fever and generalized body aches. Statistical analysis involved simple percentages with Poisson binomial 95% confidence intervals with Chi-square and Fisher's exact comparisons where appropriate. RESULTS: A total of 737 patients were evaluated and 496 (67%, 95% Confidence Interval [CI] 64-71%) were found to have at least 1 reaction to the vaccination and 187 (25%, 95% CI 22-29%) had 2 reactions or more. Overall, the majority of patients stated that the vaccination was tolerated. However, 24 (3%, 95% CI 2-5%) of the study population stated that they would not accept receipt of Tdap in a subsequent pregnancy because of the response that occurred in the current pregnancy. CONCLUSION: These data demonstrate that maternal reactions following receipt of Tdap are common (two-thirds of the study population). A potential concern is the finding that some patients might refuse a repeat vaccination in a subsequent pregnancy due to these reactions. If further research reveals similar findings, a pertussis only vaccine for pregnant patients might need to be evaluated.
[Mh] Termos MeSH primário: Vacinas contra Difteria, Tétano e Coqueluche Acelular/administração & dosagem
Vacinas contra Difteria, Tétano e Coqueluche Acelular/efeitos adversos
Complicações Infecciosas na Gravidez/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Difteria/prevenção & controle
Feminino
Febre/etiologia
Seres Humanos
Mães/psicologia
Mialgia/etiologia
Dor/etiologia
Gravidez
Estudos Prospectivos
Tétano/prevenção & controle
Vacinação
Coqueluche/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Diphtheria-Tetanus-acellular Pertussis Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:28391765
[Au] Autor:Kwiecien SY; McHugh MP; Howatson G
[Ad] Endereço:a Nicholas Institute of Sports Medicine and Athletic Trauma , Lenox Hill Hospital , New York , NY , USA.
[Ti] Título:The efficacy of cooling with phase change material for the treatment of exercise-induced muscle damage: pilot study.
[So] Source:J Sports Sci;36(4):407-413, 2018 Feb.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Post-exercise cryotherapy treatments are typically short duration interventions. This study examined the efficacy of prolonged cooling using phase change material (PCM) on strength loss and pain after eccentric exercise. Eight adults performed 120 bilateral eccentric quadriceps contractions (90% MVC). Immediately afterwards, frozen PCM packs (15°C) were placed over the quadriceps, with room temperature PCM packs on the contralateral quadriceps. Skin temperature was recorded continually (6 h PCM application). Isometric quadriceps strength and soreness were assessed before, 24, 48, 72 and 96 h post-exercise. The protocol was repeated 5 months later, with room temperature PCM applied to both legs. There were three treatments: legs treated with 15°C PCM packs (direct cooling), legs treated with room temperature PCM packs contralateral to the 15°C PCM packs (systemic cooling), and legs tested 5 months later both treated with room temperature PCM packs (control). Skin temperature was 9°C-10°C lower with direct cooling versus systemic cooling and control (P < 0.01). Strength loss and soreness were less (P < 0.05) with direct cooling versus systemic cooling and control (strength 101%, 94%, 93%, respectively; pain 1.0, 2.3, 2.7, respectively). Six hours of PCM cooling was well tolerated and reduced strength loss and pain after damaging exercise.
[Mh] Termos MeSH primário: Crioterapia/métodos
Exercício/fisiologia
Força Muscular/fisiologia
Mialgia/prevenção & controle
Músculo Quadríceps/lesões
Músculo Quadríceps/fisiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Projetos Piloto
Recuperação de Função Fisiológica
Temperatura Cutânea
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1312492


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[PMID]:29385373
[Au] Autor:Bann M; Kaul DR; Haider MZ; Saint S; Goldberger ZD
[Ad] Endereço:From the Department of Medicine (M.B., M.Z.H., Z.D.G.) and the Divisions of General Internal Medicine (M.B., M.Z.H.) and Cardiology (Z.D.G.), University of Washington School of Medicine, Harborview Medical Center, Seattle; and the Department of Internal Medicine (D.R.K., S.S.) and Division of Infect
[Ti] Título:Home Sweet Home.
[So] Source:N Engl J Med;378(5):461-466, 2018 Feb 01.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Salmonella typhi/isolamento & purificação
Viagem
Febre Tifoide/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Diagnóstico Diferencial
Feminino
Febre/etiologia
Bactérias Gram-Negativas/isolamento & purificação
Seres Humanos
Mialgia/etiologia
Sudorese
Febre Tifoide/complicações
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcps1704731


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[PMID]:28095747
[Au] Autor:Casanova N; Reis JF; Vaz JR; Machado R; Mendes B; Button DC; Pezarat-Correia P; Freitas SR
[Ad] Endereço:a CIPER, Faculdade de Motricidade Humana , Universidade de Lisboa, Estrada da Costa , Cruz Quebrada , Dafundo , Portugal.
[Ti] Título:Effects of roller massager on muscle recovery after exercise-induced muscle damage.
[So] Source:J Sports Sci;36(1):56-63, 2018 Jan.
[Is] ISSN:1466-447X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two experiments (n = 10) were conducted to determine the effects of roller massager (RM) on ankle plantar flexor muscle recovery after exercise-induced muscle damage (EIMD). Experiment 1 examined both functional [i.e., ankle plantar flexion maximal isometric contraction and submaximal (30%) sustained force; ankle dorsiflexion maximal range of motion and resistance to stretch; and medial gastrocnemius pain pressure threshold] and morphological [cross-sectional area, thickness, fascicle length, and fascicle angle] variables, before and immediately, 1, 24, 48, and 72 h after an EIMD stimulus. Experiment 2 examined medial gastrocnemius deoxyhaemoglobin concentration kinetics before and 48 h after EIMD. Participants performed both experiments twice: with (RM) and without (no-roller massager; NRM) the application of a RM (6 × 45 s; 20-s rest between sets). RM intervention did not alter the functional impairment after EIMD, as well as the medial gastrocnemius morphology and oxygenation kinetics (P > 0.05). Although, an acute increase of ipsilateral (RM = + 19%, NRM = -5%, P = 0.032) and a strong tendency for contralateral (P = 0.095) medial gastrocnemius pain pressure threshold were observed. The present results suggest that a RM has no effect on plantar flexors performance, morphology, and oxygenation recovery after EIMD, except for muscle pain pressure threshold (i.e., a soreness).
[Mh] Termos MeSH primário: Massagem/métodos
Músculo Esquelético/lesões
Mialgia/terapia
[Mh] Termos MeSH secundário: Traumatismos do Tornozelo/patologia
Traumatismos do Tornozelo/fisiopatologia
Traumatismos do Tornozelo/terapia
Articulação do Tornozelo/fisiopatologia
Feminino
Seres Humanos
Contração Isométrica/fisiologia
Masculino
Massagem/instrumentação
Músculo Esquelético/diagnóstico por imagem
Músculo Esquelético/patologia
Músculo Esquelético/fisiopatologia
Mialgia/patologia
Mialgia/fisiopatologia
Consumo de Oxigênio
Limiar da Dor/fisiologia
Amplitude de Movimento Articular/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1080/02640414.2017.1280609


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[PMID]:29382002
[Au] Autor:Lux-Battistelli C; Battistelli D
[Ti] Título:Latent scurvy with tiredness and leg pain in alcoholics: An underestimated disease three case reports.
[So] Source:Medicine (Baltimore);96(47):e8861, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Scurvy is often diagnosed at the state of well-established signs as, for example, skin and visceral purpura, gums involvement, loss of healthy teeth, which derive mostly from disturbance of collagen metabolism. Little is known about the state of latent scurvy, which symptoms are nonspecific and may mimic more common conditions such as weakness, leg pain, and muscle aching. PATIENT CONCERNS: We report 3 cases of extreme lassitude and leg pain in alcoholics. In 2 of the 3 cases, discreet classic symptoms such as petechiae or hyperkeratosis of the legs involving collagen metabolism were also present. DIAGNOSES: Latent scurvy has been diagnosed thanks to historical experimental data reporting and undetectable ascorbic acid levels. INTERVENTIONS: In addition to the treatments recommended by the French Alcohol Society, patients were given oral vitamin C 500 mg to 1000 mg per day for at least three months. OUTCOMES: Vitamin C supplementation allowed the regression of the symptoms, greatly improved the quality of life, and gave the possibility to return to work. Cartinine, requiring vitamin C for its hydroxylation, is an essential cofactor in the transport of long-chain fatty acid into mitochondrial matrix. Therefore, it plays an important role in energy production via beta-oxidation. It is thought that carnitine metabolism impairment is responsible for weakness or muscle aching. LESSONS: We recommend being aware of the possibility of latent scurvy in chronic alcohol abusers. The vitamin C supplementation and dietetic recommendation eating fresh fruit and vegetables may help to cure tiredness and to return more easily to socialization and to work.
[Mh] Termos MeSH primário: Alcoolismo/complicações
Fadiga/etiologia
Mialgia/etiologia
Escorbuto/etiologia
[Mh] Termos MeSH secundário: Adulto
Ácido Ascórbico/administração & dosagem
Suplementos Nutricionais
Fadiga/terapia
Seres Humanos
Perna (Membro)
Masculino
Meia-Idade
Mialgia/terapia
Escorbuto/terapia
Vitaminas/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vitamins); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008861


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[PMID]:28742609
[Au] Autor:Xie Y; Feng B; Chen K; Andersen LL; Page P; Wang Y
[Ad] Endereço:Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, PRC China.
[Ti] Título:The Efficacy of Dynamic Contract-Relax Stretching on Delayed-Onset Muscle Soreness Among Healthy Individuals: A Randomized Clinical Trial.
[So] Source:Clin J Sport Med;28(1):28-36, 2018 Jan.
[Is] ISSN:1536-3724
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the efficacy of dynamic contract-relax stretching on delayed-onset muscle soreness (DOMS) in the calf muscle of healthy individuals. DESIGN: Randomized clinical trial. SETTING: Research laboratory. PARTICIPANTS: Three groups of 16 healthy participants (n = 48) were recruited by convenience sampling. INTERVENTIONS: Three sets of resisted bilateral heel-raising exercises until exhaustion were conducted to initiate DOMS. Participants were randomly allocated into control group without any interventions, dynamic contract-relax stretching (DS), or static stretching (SS) groups. Dynamic contract-relax stretching and SS groups performed DS and SS, respectively, on the dominant leg twice a day for 5 consecutive days (before time points of outcome measurements at 24, 48, 72, 96, and 120 hours postexercise, respectively). MAIN OUTCOME MEASURES: Muscle soreness, lower leg girth, pressure pain threshold (PPT), range of motion (ROM), and muscle strength were measured before exercise, immediately after, and at 24, 48, 72, 96, and 120 hours postexercise. RESULTS: There was a significant effect of time in all outcome measures including muscle soreness, lower leg girth, PPT, ROM, and muscle strength; however, there were no significant group differences or group by time interactions. CONCLUSIONS: The effect of DS on relieving DOMS in the calf muscle is insignificant in this study. Further evidence is needed to prove the efficacy of DS on DOMS. CLINICAL RELEVANCE: Stretching is commonly recommended before and after exercise; however, this study showed no significant impact of DS or SS in treating DOMS.
[Mh] Termos MeSH primário: Exercícios de Alongamento Muscular/métodos
Músculo Esquelético/fisiopatologia
Mialgia/terapia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Força Muscular
Medição da Dor
Amplitude de Movimento Articular
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1097/JSM.0000000000000442


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[PMID]:27776506
[Au] Autor:Christensen JR; Bredahl TV; Hadrévi J; Sjøgaard G; Søgaard K
[Ad] Endereço:Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. jrchristensen@health.sdu.dk.
[Ti] Título:Background, design and conceptual model of the cluster randomized multiple-component workplace study: FRamed Intervention to Decrease Occupational Muscle pain - "FRIDOM".
[So] Source:BMC Public Health;16(1):1116, 2016 10 24.
[Is] ISSN:1471-2458
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several RCT studies have aimed to reduce either musculoskeletal disorders, sickness presenteeism, sickness absenteeism or a combination of these among females with high physical work demands. These studies have provided evidence that workplace health promotion (WHP) interventions are effective, but long-term effects are still uncertain. These studies either lack to succeed in maintaining intervention effects or lack to document if effects are maintained past a one-year period. This paper describes the background, design and conceptual model of the FRIDOM (FRamed Intervention to Decrease Occupational Muscle pain) WHP program among health care workers. A job group characterized by having high physical work demands, musculoskeletal disorders, high sickness presenteeism - and absenteeism. METHODS: FRIDOM aimed to reduce neck and shoulder pain. Secondary aims were to decrease sickness presenteeism, sickness absenteeism and lifestyle-diseases such as other musculoskeletal disorders as well as metabolic-, and cardiovascular disorders - and to maintain participation to regular physical exercise training, after a one year intervention period. The entire concept was tailored to a population of female health care workers. This was done through a multi-component intervention including 1) intelligent physical exercise training (IPET), dietary advice and weight loss (DAW) and cognitive behavioural training (CBT). DISCUSSION: The FRIDOM program has the potential to provide evidence-based knowledge of the pain reducing effect of a multi component WHP among a female group of employees with a high prevalence of musculoskeletal disorders and in a long term perspective evaluate the effects on sickness presenteeism and absenteeism as well as risk of life-style diseases. TRIAL REGISTRATION: NCT02843269 , 06.27.2016 - retrospectively registered.
[Mh] Termos MeSH primário: Pessoal de Saúde
Promoção da Saúde
Dor Musculoesquelética/prevenção & controle
Mialgia/prevenção & controle
Exposição Ocupacional/efeitos adversos
Saúde do Trabalhador
Local de Trabalho
[Mh] Termos MeSH secundário: Absenteísmo
Adulto
Exercício
Feminino
Seres Humanos
Estilo de Vida
Masculino
Doenças Musculoesqueléticas/etiologia
Doenças Musculoesqueléticas/prevenção & controle
Dor Musculoesquelética/etiologia
Pescoço
Cervicalgia
Presenteísmo
Projetos de Pesquisa
Ombro
Dor de Ombro
Trabalho
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:29211743
[Au] Autor:Yeh CY; Chen PL; Chuang KT; Shu YC; Chien YW; Perng GC; Ko WC; Ko NY
[Ad] Endereço:Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
[Ti] Título:Symptoms associated with adverse dengue fever prognoses at the time of reporting in the 2015 dengue outbreak in Taiwan.
[So] Source:PLoS Negl Trop Dis;11(12):e0006091, 2017 Dec.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tainan experienced the most severe dengue epidemic in Taiwan in 2015. This study investigates the association between the signs and symptoms at the time of reporting with the adverse dengue prognoses. METHODS: A descriptive study was conducted using secondary data from the Dengue Disease Reporting System in Tainan, Taiwan, between January 1 and December 31, 2015. A multivariate stepwise logistic regression was used to identify the risk factors for the adverse prognoses: ICU admissions and mortality. RESULTS: There were 22,777 laboratory-confirmed reported cases (mean age 45.6 ± 21.2 years), of which 3.7% were admitted to intensive care units (ICU), and 0.8% were fatal. The most common symptoms were fever (92.8%), myalgia (26.6%), and headache (22.4%). The prevalence of respiratory distress, altered consciousness, shock, bleeding, and thrombocytopenia increased with age. The multivariate analysis indicated that being in 65-89 years old age group [Adjusted Odds Ratio (aOR):4.95], or the 90 years old and above age group (aOR: 9.06), and presenting with shock (aOR: 8.90) and respiratory distress (aOR: 5.31) were significantly associated with the risk of ICU admission. While old age (aOR: 1.11), respiratory distress (aOR: 9.66), altered consciousness (aOR: 7.06), and thrombocytopenia (aOR: 2.55) were significantly associated with the risk of mortality. CONCLUSIONS: Dengue patients older than 65 and those with severe and non-specific signs and symptoms at the time of reporting were at a higher risk of ICU admission and mortality. First-line healthcare providers need to be aware of the varied presentations between the different age groups to allow early diagnosis and in-time management, which would prevent ICU admissions and fatalities in dengue patients.
[Mh] Termos MeSH primário: Dengue/epidemiologia
Surtos de Doenças
Sistema de Registros
Dengue Grave/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Dengue/diagnóstico
Dengue/mortalidade
Dengue/virologia
Epidemias
Feminino
Febre
Hospitalização
Seres Humanos
Unidades de Terapia Intensiva
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Mialgia
Razão de Chances
Prognóstico
Estudos Retrospectivos
Fatores de Risco
Dengue Grave/diagnóstico
Dengue Grave/mortalidade
Dengue Grave/virologia
Taiwan/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006091


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[PMID]:29078865
[Au] Autor:Khawaja SN; Scrivani SJ; Holland N; Keith DA
[Ad] Endereço:Resident, Division of Oral and Maxillofacial Pain, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA; and Post-Graduate Fellow, Harvard School of Dental Medicine, Harvard University, Boston, MA. Electronic address: khawajashehryar@gmail.com.
[Ti] Título:Effectiveness, Safety, and Predictors of Response to Botulinum Toxin Type A in Refractory Masticatory Myalgia: A Retrospective Study.
[So] Source:J Oral Maxillofac Surg;75(11):2307-2315, 2017 Nov.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Masticatory muscle pain disorders respond well to conservative therapy; however, in some patients the pain becomes refractory. Botulinum toxin type A (BoT-A) therapy has been shown to be an effective modality in the management of refractory headache disorders. Conversely, there are conflicting reports in the literature regarding the efficacy, safety, and predictors of therapeutic response to BoT-A therapy for management of refractory masticatory muscle pain. MATERIALS AND METHODS: We performed a retrospective chart review of patients who underwent at least 2 injection cycles of 100 U of BoT-A for refractory masticatory myalgia in the Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, between May 2012 and June 2016. Information regarding demographic, diagnostic, and therapeutic characteristics was extracted and analyzed. The χ test was used for analysis between independent and dependent variables. Forward step-wise-type logistic regression analysis was conducted to determine the predictors of outcome. RESULTS: Among 116 participants, 30.6% reported significant relief in pain for a mean period of 10.1 weeks. A total of 16.4% of participants reported at least 1 adverse effect. The effectiveness of the BoT-A therapy was found to be statistically associated with the presence of muscle hypertrophy (P = .004), range of motion (P = .02), concurrent use of opioid analgesics (P = .003), and local anesthetic trigger-point injections (P = .003). Logistic regression analyses suggested that the presence of muscle hypertrophy and occurrence of adverse effects were predictors of positive outcome. On the contrary, concurrent use of opioid analgesics was found to be a predictor for no or minimal relief. CONCLUSIONS: BoT-A therapy provides significant relief for approximately one third of patients with refractory masticatory muscle pain. Therapy is associated with a mild risk of adverse effects. The presence of muscle hypertrophy, occurrence of an adverse effect, and concurrent use of opioid analgesics were found to be predictors of outcome response.
[Mh] Termos MeSH primário: Toxinas Botulínicas Tipo A/uso terapêutico
Músculos da Mastigação
Mialgia/tratamento farmacológico
Fármacos Neuromusculares/uso terapêutico
[Mh] Termos MeSH secundário: Toxinas Botulínicas Tipo A/efeitos adversos
Feminino
Previsões
Seres Humanos
Masculino
Meia-Idade
Fármacos Neuromusculares/efeitos adversos
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuromuscular Agents); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE



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