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[PMID]:29246992
[Au] Autor:Berner D
[Ad] Endereço:Department of Clinical Science & Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
[Ti] Título:Diagnostic imaging of tendinopathies of the superficial flexor tendon in horses.
[So] Source:Vet Rec;181(24):652-654, 2017 12 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Tendinopatia
Tendões
[Mh] Termos MeSH secundário: Animais
Diagnóstico por Imagem
Membro Anterior
Doenças dos Cavalos
Cavalos
Traumatismos dos Tendões/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1136/vr.j5746


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[PMID]:29217766
[Au] Autor:Alzola Domingo R; Riggs CM; Gardner DS; Freeman SL
[Ad] Endereço:Equine Department, Oakham Veterinary Hospital, Oakham, UK.
[Ti] Título:Ultrasonographic scoring system for superficial digital flexor tendon injuries in horses: intra- and inter-rater variability.
[So] Source:Vet Rec;181(24):655, 2017 Dec 16.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Superficial digital flexor tendon (SDFT) tendinopathy is an important musculoskeletal problem in horses. The study objective was to validate an ultrasonographic scoring system for SDFT injuries. Ultrasonographic images from 14 Thoroughbred racehorses with SDFT lesions (seven core; seven diffuse) and two controls were blindly assessed by five clinicians on two occasions. Ultrasonographic parameters evaluated were: type and extent of the injury, location, echogenicity, cross-sectional area and longitudinal fibre pattern of the maximal injury zone (MIZ). Inter-rater variability and intra-rater reliability were assessed using Kendall's coefficient of concordance (KC) and Lin's concordance correlation coefficient (LC), respectively. Type of injury (core vs. diffuse) had perfect inter/intra-rater agreement. Cases with core lesions had very strong inter-rater agreement (KC ≥0.74, P<0.001) and intra-rater reliability (LC ≥0.73) for all parameters apart from echogenicity. Cases with diffuse lesions had strong inter-rater agreement (KC ≥0.62) for all parameters, but weak agreement for echogenicity (KC=0.22); intra-rater reliability was excellent for MIZ location and fibre pattern (LC ≥0.82), and moderate (LC ≥0.58) for cross-sectional area and number of zones affected. This scoring system was reliable and repeatable for all parameters, except for echogenicity. A validated scoring system will facilitate reliable recording of SDFT injuries and inter-study meta-analyses.
[Mh] Termos MeSH primário: Doenças dos Cavalos/diagnóstico por imagem
Tendinopatia/veterinária
Ultrassonografia/veterinária
[Mh] Termos MeSH secundário: Animais
Cavalos
Reprodutibilidade dos Testes
Tendinopatia/diagnóstico por imagem
Ultrassonografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE
[do] DOI:10.1136/vr.104233


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[PMID]:29212688
[Au] Autor:Chou WY; Wang CJ; Wu KT; Yang YJ; Ko JY; Siu KK
[Ad] Endereço:Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
[Ti] Título:Prognostic factors for the outcome of extracorporeal shockwave therapy for calcific tendinitis of the shoulder.
[So] Source:Bone Joint J;99-B(12):1643-1650, 2017 Dec.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: We conducted a study to identify factors that are prognostic of the outcome of extracorporeal shockwave therapy (ESWT) for calcific tendinitis of the shoulder. PATIENTS AND METHODS: Since 1998, patients with symptomatic calcific tendinitis of the rotator cuff have been treated with ESWT using an electrohydraulic mode shockwave device. One year after ESWT, patients were grouped according to the level of resorption of calcification. RESULTS: Of 241 symptomatic shoulders, complete resorption (CR) of calcification occurred in 134 (CR group). The remaining 107 shoulders had incomplete resorption (ICR) (ICR group). Gartner type I calcification was most common (64.5%) in the ICR group. The mean duration of symptoms before ESWT was significantly longer in the ICR group. Overall, 81% of the CR group and 23.4% of the ICR group were symptom free. There was a strong relationship between subsidence of symptoms and remission of calcification. Poor prognosis was significantly related to Gartner type I calcification, calcification extent > 15 mm and duration of symptoms > 11 months. CONCLUSION: Patients with calcific tendinitis of the shoulder who have the factors identified for a poor outcome after ESWT should undergo a different procedure. Cite this article: 2017;99-B:1643-50.
[Mh] Termos MeSH primário: Calcinose/terapia
Tratamento por Ondas de Choque Extracorpóreas
Manguito Rotador
Dor de Ombro/terapia
Ombro
Tendinopatia/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Calcinose/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Amplitude de Movimento Articular
Manguito Rotador/diagnóstico por imagem
Ombro/diagnóstico por imagem
Dor de Ombro/etiologia
Tendinopatia/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B12.BJJ-2016-1178.R1


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[PMID]:29023489
[Au] Autor:Biasutti S; Dart A; Smith M; Blaker C; Clarke E; Jeffcott L; Little C
[Ad] Endereço:Research and Clinical Training Unit, University Veterinary Teaching Hospital, University of Sydney, Camden, Australia.
[Ti] Título:Spatiotemporal variations in gene expression, histology and biomechanics in an ovine model of tendinopathy.
[So] Source:PLoS One;12(10):e0185282, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Flexor tendinopathy is a common problem affecting humans and animals. Tendon healing is poorly understood and the outcomes of conservative and surgical management are often suboptimal. While often considered a localized injury, recent evidence indicates that in the short term, tendinopathic changes are distributed widely throughout the tendon, remote from the lesion itself. Whether these changes persist throughout healing is unknown. The aim of this study was to document gene expression, histopathological and biomechanical changes that occur throughout the superficial digital flexor tendon (SDFT) up to 16 weeks post-injury, using an ovine surgical model of tendinopathy. Partial tendon transection was associated with decreased gene expression for aggrecan, decorin, fibromodulin, tissue inhibitors of metalloproteinases (TIMPS 1, 2 and 3), collagen I and collagen II. Gene expression for collagen III, lumican and matrix metalloproteinase 13 (MMP13) increased locally around the lesion site. Expression of collagen III and MMP13 decreased with time, but compared to controls, collagen III, MMP13 and lumican expression remained regionally high throughout the study. An increase in TIMP3 was observed over time. Histologically, operated tendons had higher pathology scores than controls, especially around the injured region. A chondroid phenotype was observed with increased cellular rounding and marked proteoglycan accumulation which only partially improved with time. Biomechanically, partial tendon transection resulted in a localized decrease in elastic modulus (in compression) but only at 8 weeks postoperatively. This study improves our understanding of tendon healing, demonstrating an early 'peak' in pathology characterized by altered gene expression and notable histopathological changes. Many of these pathological changes become more localized to the region of injury during healing. Collagen III and MMP13 expression levels remained high close to the lesion throughout the study and may reflect the production of tendon tissue with suboptimal biomechanical properties. Further studies evaluating the long-term response of tendon to injury (6-12 months) are warranted to provide additional information on tendon healing and provide further understanding of the mechanisms underlying the pathology observed in this study.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Modelos Animais de Doenças
Perfilação da Expressão Gênica
Regulação da Expressão Gênica
Análise Espaço-Temporal
Tendinopatia/genética
Tendões/metabolismo
[Mh] Termos MeSH secundário: Animais
Fenômenos Biomecânicos
Técnicas Imunoenzimáticas
Masculino
Ovinos
Tendinopatia/metabolismo
Tendinopatia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185282


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[PMID]:28697880
[Au] Autor:Romero A; Barrachina L; Ranera B; Remacha AR; Moreno B; de Blas I; Sanz A; Vázquez FJ; Vitoria A; Junquera C; Zaragoza P; Rodellar C
[Ad] Endereço:Laboratorio de Genética Bioquímica (LAGENBIO), Instituto de Investigación Sanitaria de Aragón (IIS), Universidad de Zaragoza, 50013 Zaragoza, Spain; Servicio de Cirugía y Medicina Equina, Hospital Veterinario, Universidad de Zaragoza, 50013 Zaragoza, Spain.
[Ti] Título:Comparison of autologous bone marrow and adipose tissue derived mesenchymal stem cells, and platelet rich plasma, for treating surgically induced lesions of the equine superficial digital flexor tendon.
[So] Source:Vet J;224:76-84, 2017 Jun.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several therapies have been investigated for equine tendinopathies, but satisfactory long term results have not been achieved consistently and a better understanding of the healing mechanism elicited by regenerative therapies is needed. The aim of this study was to assess the separate effects of autologous bone marrow (BM) and adipose tissue (AT) derived mesenchymal stem cells (MSCs), and platelet rich plasma (PRP), for treating lesions induced in the superficial digital flexor tendon (SDFT) of horses. Lesions were created surgically in both SDFTs of the forelimbs of 12 horses and were treated with BM-MSCs (six tendons), AT-MSCs (six tendons) or PRP (six tendons). The remaining six tendons received lactated Ringer's solution as control. Serial ultrasound assessment was performed prior to treatment and at 2, 6, 10, 20 and 45 weeks post-treatment. At 45 weeks, histopathology and gene expression analyses were performed. At week 6, the ultrasound echogenicity score in tendons treated with BM-MSCs suggested earlier improvement, whilst all treatment groups reached the same level at week 10, which was superior to the control group. Collagen orientation scores on histological examination suggested a better outcome in treated tendons. Gene expression was indicative of better tissue regeneration after all treatments, especially for BM-MSCs, as suggested by upregulation of collagen type I, decorin, tenascin and matrix metalloproteinase III mRNA. Considering all findings, a clear beneficial effect was elicited by all treatments compared with the control group. Although differences between treatments were relatively small, BM-MSCs resulted in a better outcome than PRP and AT-MSCs.
[Mh] Termos MeSH primário: Tecido Adiposo/citologia
Transplante de Medula Óssea/veterinária
Doenças dos Cavalos/terapia
Plasma Rico em Plaquetas
Traumatismos dos Tendões/veterinária
[Mh] Termos MeSH secundário: Animais
Autoenxertos
Doenças dos Cavalos/cirurgia
Cavalos
Complicações Intraoperatórias/terapia
Complicações Intraoperatórias/veterinária
Transplante de Células-Tronco Mesenquimais/veterinária
Tendinopatia/terapia
Tendinopatia/veterinária
Traumatismos dos Tendões/etiologia
Traumatismos dos Tendões/terapia
Tendões/diagnóstico por imagem
Tendões/patologia
Tendões/cirurgia
Ultrassonografia/veterinária
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE


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[PMID]:28613120
[Au] Autor:Orlandi D; Mauri G; Lacelli F; Corazza A; Messina C; Silvestri E; Serafini G; Sconfienza LM
[Ad] Endereço:From the Department of Radiology, Ospedale Evangelico Internazionale, Genoa, Italy (D.O., E.S.); Division of Interventional Radiology, Istituto Europeo di Oncologia, Milan, Italy (G.M.); Department of Diagnostic Radiology, ASL 2 Savonese, Presidio di Santa Corona, Pietra Ligure, Italy (F.L., G.S.);
[Ti] Título:Rotator Cuff Calcific Tendinopathy: Randomized Comparison of US-guided Percutaneous Treatments by Using One or Two Needles.
[So] Source:Radiology;285(2):518-527, 2017 Nov.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To determine whether the use of one or two needles influences procedure performance and patient outcomes for ultrasonography (US)-guided percutaneous irrigation of calcific tendinopathy. Materials and Methods Institutional review board approval and written informed patient consent were obtained. From February 2012 to December 2014, 211 patients (77 men and 134 women; mean age, 41.6 years ± 11.6; range, 24-69 years) with painful calcific tendinopathy diagnosed at US were prospectively enrolled and randomized. Operators subjectively graded calcifications as hard, soft, or fluid according to their appearance at US. US-guided percutaneous irrigation of calcific tendinopathy (local anesthesia, needle lavage, intrabursal steroid injection) was performed in 100 patients by using the single-needle procedure and in 111 patients by using the double-needle procedure. Calcium dissolution was subjectively scored (easy = 1; intermediate = 2; difficult = 3). Procedure duration was recorded. Clinical evaluation was performed by using the Constant score up to 1 year after the procedure. The occurrence of postprocedural bursitis was recorded. Mann-Whitney U, χ , and analysis of variance statistics were used. Results No difference in procedure duration was seen overall (P = .060). Procedure duration was shorter with the double-needle procedure in hard calcifications (P < .001) and with the single-needle procedure in fluid calcifications (P = .024). Ease of calcium dissolution was not different between single- and double-needle procedures, both overall and when considering calcification appearance (P > .089). No clinical differences were found (Constant scores for single-needle group: baseline, 55 ± 7; 1 month, 69 ± 7; 3 month, 90 ± 5; 1 year, 92 ± 4; double-needle group: 57 ± 6; 71 ± 9; 89 ± 7; 92 ± 4, respectively; P = .241). In the single-needle group, nine of 100 cases (9%) of postprocedural bursitis were seen, whereas four of 111 cases (3.6%) were seen in the double-needle group (P = .180). Conclusion The only difference between using the single- or double-needle procedure when performing US-guided percutaneous irrigation of calcific tendinopathy is procedure duration in hard and fluid calcifications. Clinical outcomes are similar up to 1 year. RSNA, 2017.
[Mh] Termos MeSH primário: Calcinose/diagnóstico por imagem
Calcinose/cirurgia
Manguito Rotador/diagnóstico por imagem
Manguito Rotador/cirurgia
Tendinopatia/diagnóstico por imagem
Tendinopatia/cirurgia
Ultrassonografia de Intervenção/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Calcinose/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Agulhas
Estudos Prospectivos
Tendinopatia/epidemiologia
Resultado do Tratamento
Ultrassonografia de Intervenção/estatística & dados numéricos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017162888


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[PMID]:28566400
[Au] Autor:Ketola S; Lehtinen JT; Arnala I
[Ad] Endereço:Coxa Hospital for Joint Replacement, Biokatu 6b, 33101 Tampere, Finland.
[Ti] Título:Arthroscopic decompression not recommended in the treatment of rotator cuff tendinopathy: a final review of a randomised controlled trial at a minimum follow-up of ten years.
[So] Source:Bone Joint J;99-B(6):799-805, 2017 Jun.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Rotator cuff tendinopathy has a multifactorial origin. Rejecting the mechanistic theory has also led to abandoning operative treatment at initial presentation in the first line. Physiotherapy exercise programmes are the accepted first line treatment. The aim of this study was to assess the long-term additional benefits of subacromial decompression in the treatment of rotator cuff tendinopathy. PATIENTS AND METHODS: This randomised controlled trial of 140 patients (52 men, 88 women, mean age 47.1 years; 18 to 60) with rotator cuff tendinopathy extended previous work up to a maximum of 13 years. The patients were randomised into two treatment groups: arthroscopic acromioplasty and a supervised exercise treatment and a similar supervised exercise treatment alone. Self-reported pain on a visual analogue scale (VAS) was the primary outcome measure. Secondary measures were disability, working ability, pain at night, Shoulder Disability Questionnaire score and the number of painful days during the three months preceding the final assessment. RESULTS: A total of 90 patients (64%) returned questionnaires at a mean 12 years after randomisation. On an intention-to-treat basis, both treatment groups reached statistically significant improvement compared with the initial VAS for pain, but there was no significant difference between groups. The same was true in the secondary outcome measures. Due to group changes, the results were also analysed per protocol: operated or not. No significant differences between the groups were found. CONCLUSION: The natural history of rotator cuff tendinopathy probably plays a significant role in the results in the long-term. Even though the patients who underwent operative treatment had a stronger belief in recovery, which is likely to be surgical and the effect of placebo, the exercise group obtained similar results. In the future, an optimum exercise regime should be searched for, as the most clinically and cost-effective conservative treatment for rotator cuff tendinopathy. Cite this article: 2017;99-B:799-805.
[Mh] Termos MeSH primário: Artroscopia/métodos
Descompressão Cirúrgica/métodos
Manguito Rotador/cirurgia
Tendinopatia/cirurgia
[Mh] Termos MeSH secundário: Acrômio/cirurgia
Adolescente
Adulto
Artroscopia/efeitos adversos
Descompressão Cirúrgica/efeitos adversos
Avaliação da Deficiência
Terapia por Exercício/métodos
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Dor Pós-Operatória
Retorno ao Trabalho/estatística & dados numéricos
Autorrelato
Dor de Ombro/etiologia
Método Simples-Cego
Tendinopatia/reabilitação
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B6.BJJ-2016-0569.R1


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[PMID]:28400182
[Au] Autor:Wu YC; Tsai WC; Tu YK; Yu TY
[Ad] Endereço:Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
[Ti] Título:Comparative Effectiveness of Nonoperative Treatments for Chronic Calcific Tendinitis of the Shoulder: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
[So] Source:Arch Phys Med Rehabil;98(8):1678-1692.e6, 2017 Aug.
[Is] ISSN:1532-821X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effectiveness of various nonoperative treatments for chronic calcific tendinitis of the shoulder, a systematic review and network meta-analysis of randomized trials was performed to evaluate changes in pain reduction, functional improvements in patients with calcific tendinitis, and the ratio of complete resolution of calcific deposition. DATA SOURCES: Studies were comprehensively searched, without language restrictions, on PubMed, Embase, Cochrane Controlled Trials Register, the Cochrane, and other databases. The reference lists of articles and reviews were cross-checked for possible studies. STUDY SELECTION: Randomized controlled trials from before August 2016 were included. Study selection was conducted by 2 reviewers independently. DATA EXTRACTION: The quality of studies was assessed and data extracted by 2 independent reviewers. Disagreements were settled by consulting a third reviewer to reach a consensus. DATA SYNTHESIS: Fourteen studies with 1105 participants were included in the network meta-analysis that used a random-effect model to investigate the mean difference of pooled effect sizes of the visual analog scale, Constant-Murley score, and the ratio of complete resolution of calcific deposition on native radiographs. CONCLUSIONS: The present network meta-analysis demonstrates that ultrasound-guided needling (UGN), radial extracorporeal shockwave therapy (RSW), and high-energy focused extracorporeal shockwave therapy (H-FSW) alleviate pain and achieve complete resolution of calcium deposition. Compared with low-energy focused extracorporeal shockwave therapy, transcutaneous electrical nerve stimulation, and ultrasound therapy, H-FSW is the best therapy for providing functional recovery. Physicians should consider UGN, RSW, and H-FSW as alternative effective therapies for chronic calcific tendinitis of the shoulder when initial conservative treatment fails.
[Mh] Termos MeSH primário: Calcinose/reabilitação
Modalidades de Fisioterapia
Dor de Ombro/reabilitação
Tendinopatia/reabilitação
[Mh] Termos MeSH secundário: Ondas de Choque de Alta Energia/uso terapêutico
Seres Humanos
Agulhas
Metanálise em Rede
Ensaios Clínicos Controlados Aleatórios como Assunto
Estimulação Elétrica Nervosa Transcutânea/métodos
Terapia por Ultrassom/métodos
Ultrassonografia de Intervenção
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE


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[PMID]:28399642
[Au] Autor:Jackson LT; Dunaway LJ; Lundeen GA
[Ad] Endereço:1 Slocum Center for Orthopedics & Sports Medicine, Eugene, Oregon, USA.
[Ti] Título:Acute Tears of the Tibialis Posterior Tendon Following Ankle Sprain.
[So] Source:Foot Ankle Int;38(7):752-759, 2017 Jul.
[Is] ISSN:1944-7876
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Traumatic tears of the tibialis posterior (TP) tendon following an ankle sprain are rare. The purpose of this study was to report our case series of TP tendon tears following an ankle sprain. METHODS: Patients with persistent TP tendon pain after an ankle sprain were retrospectively identified over a 4-year period and reviewed. A comparison of magnetic resonance imaging (MRI) interpretations by a radiologist and surgeon was made. Patients failing conservative management underwent operative repair of the TP tendon tear and concomitant pathology. Failure of the index surgery was defined as TP tendinosis, which was treated with excision and flexor digitorum longus tendon transfer. Outcomes were measured with the Foot Function Index (FFI) and American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot scores. RESULTS: Thirteen patients were found to have a TP tendon tear following an ankle sprain. The incidence for TP tears with sprains presented to our clinic was 1.04%. MRI identified TP tendon pathology in 4 patients by a radiologist review and in 11 patients by a surgeon review. The most common concomitant pathology was a talar osteochondral defect in 13 of 13 patients and ligament instability in 12 of 13 patients (5/13 lateral, 3/13 medial, 4/13 multidirectional instability). Four of 13 patients failed the index surgery. Of the 9 remaining patients, 4 had clinical follow-up at an average of 4.6 years postoperatively. The average FFI subscale scores were the following: pain, 40.4; disability, 28.9; and activity, 23.6. The average AOFAS hindfoot score was 68.8. CONCLUSION: Despite being rare, a TP tendon tear should be included in the differential diagnosis for persistent medial-sided pain following an ankle sprain. MRI findings can be subtle. Associated pathology was very common and likely confounded the diagnosis and outcomes. Patients should be counseled on the possibility of poor outcomes and long-term pain. LEVEL OF EVIDENCE: Level IV, case series.
[Mh] Termos MeSH primário: Traumatismos do Tornozelo/cirurgia
/fisiopatologia
Ruptura/cirurgia
Traumatismos dos Tendões/cirurgia
Tendões/cirurgia
[Mh] Termos MeSH secundário: Traumatismos do Tornozelo/fisiopatologia
Seres Humanos
Imagem por Ressonância Magnética
Ruptura/fisiopatologia
Tendinopatia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1177/1071100717701686


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[PMID]:28358823
[Au] Autor:Kim SK; Roos TR; Roos AK; Kleimeyer JP; Ahmed MA; Goodlin GT; Fredericson M; Ioannidis JP; Avins AL; Dragoo JL
[Ad] Endereço:Department Developmental Biology, Stanford University Medical Center, Stanford CA, United States of America.
[Ti] Título:Genome-wide association screens for Achilles tendon and ACL tears and tendinopathy.
[So] Source:PLoS One;12(3):e0170422, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Achilles tendinopathy or rupture and anterior cruciate ligament (ACL) rupture are substantial injuries affecting athletes, associated with delayed recovery or inability to return to competition. To identify genetic markers that might be used to predict risk for these injuries, we performed genome-wide association screens for these injuries using data from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort consisting of 102,979 individuals. We did not find any single nucleotide polymorphisms (SNPs) associated with either of these injuries with a p-value that was genome-wide significant (p<5x10-8). We found, however, four and three polymorphisms with p-values that were borderline significant (p<10-6) for Achilles tendon injury and ACL rupture, respectively. We then tested SNPs previously reported to be associated with either Achilles tendon injury or ACL rupture. None showed an association in our cohort with a false discovery rate of less than 5%. We obtained, however, moderate to weak evidence for replication in one case; specifically, rs4919510 in MIR608 had a p-value of 5.1x10-3 for association with Achilles tendon injury, corresponding to a 7% chance of false replication. Finally, we tested 2855 SNPs in 90 candidate genes for musculoskeletal injury, but did not find any that showed a significant association below a false discovery rate of 5%. We provide data containing summary statistics for the entire genome, which will be useful for future genetic studies on these injuries.
[Mh] Termos MeSH primário: Lesões do Ligamento Cruzado Anterior/genética
Estudo de Associação Genômica Ampla
MicroRNAs/genética
Tendinopatia/genética
[Mh] Termos MeSH secundário: Tendão do Calcâneo/diagnóstico por imagem
Tendão do Calcâneo/lesões
Tendão do Calcâneo/fisiopatologia
Idoso
Ligamento Cruzado Anterior/diagnóstico por imagem
Ligamento Cruzado Anterior/fisiopatologia
Lesões do Ligamento Cruzado Anterior/diagnóstico por imagem
Lesões do Ligamento Cruzado Anterior/fisiopatologia
Feminino
Predisposição Genética para Doença
Seres Humanos
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único
Tendinopatia/diagnóstico por imagem
Tendinopatia/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (MIRN608 microRNA, human); 0 (MicroRNAs)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170422



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