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[PMID]:28468208
[Au] Autor:Sisti A; Freda N; Giacomina A; Gatti GL
[Ad] Endereço:Plastic and Reconstructive Surgery, Santa Chiara Hospital, Pisa, Italy.
[Ti] Título:Popliteal Pterygium Syndrome With Syngnathia.
[So] Source:J Craniofac Surg;28(3):e250-e251, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Popliteal pterygium syndrome is a condition characterized by skin webs on the popliteal fossa, which may impair mobility unless surgically repaired. Affected individuals may also have syndactyly on the fingers and/or toes. Most people with this disorder present cleft lip and cleft palate and they can have syngnathia, that is a congenital adhesion between maxilla and mandible by fibrous bands, which affects the opening of the mouth. The case that we report is about a 2-month-old male, who presented skin webs bilaterally on the popliteal fossa, syndactyly between the IV and the V toe of the right foot and between the III and the IV toe of the left foot, and genital malformations. He was born with complete bilateral cleft lip and complete cleft palate on the left side and incomplete cleft palate on the right side and syngnathia with 4 fibrous bands between the mandibular arch and the maxilla arch on the right side, which affected the opening of the mouth. The case of our patient is very interesting because there have been few reported patients affected by popliteal pterygium syndrome with syngnathia.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/diagnóstico
Fenda Labial/diagnóstico
Fissura Palatina/diagnóstico
Anormalidades do Olho/diagnóstico
Dedos/anormalidades
Articulação do Joelho/anormalidades
Deformidades Congênitas das Extremidades Inferiores/diagnóstico
Mandíbula/anormalidades
Maxila/anormalidades
Sindactilia/diagnóstico
Anormalidades Urogenitais/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003473


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[PMID]:28925669
[Au] Autor:Rerucha CM; Dickison C; Baird DC
[Ad] Endereço:Carl R. Darnall Army Medical Center, Fort Hood, TX, USA.
[Ti] Título:Lower Extremity Abnormalities in Children.
[So] Source:Am Fam Physician;96(4):226-233, 2017 Aug 15.
[Is] ISSN:1532-0650
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Leg and foot problems in childhood are common causes of parental concern. Rotational problems include intoeing and out-toeing. Intoeing is most common in infants and young children. Intoeing is caused by metatarsus adductus, internal tibial torsion, and femoral anteversion. Out-toeing is less common than intoeing and occurs more often in older children. Out-toeing is caused by external tibial torsion and femoral retroversion. Angular problems include genu varum (bowleg) and genu valgum (knock knee). With pes planus (flatfoot), the arch of the foot is usually flexible rather than rigid. A history and physical examination that include torsional profile tests and angular measurements are usually sufficient to evaluate patients with lower extremity abnormalities. Most children who present with lower extremity problems have normal rotational and angular findings (i.e., within two standard deviations of the mean). Lower extremity abnormalities that are within normal measurements resolve spontaneously as the child grows. Radiologic studies are not routinely required, except to exclude pathologic conditions. Orthotics are not beneficial. Orthopedic referral is often not necessary. Rarely, surgery is required in patients older than eight years who have severe deformities that cause dysfunction.
[Mh] Termos MeSH primário: Marcha/fisiologia
Deformidades Congênitas das Extremidades Inferiores/terapia
Dispositivos de Fixação Ortopédica/normas
Exame Físico/normas
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Seres Humanos
Lactente
Deformidades Congênitas das Extremidades Inferiores/diagnóstico
Exame Físico/métodos
Encaminhamento e Consulta
Sapatos/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:28278134
[Au] Autor:Youssef AO
[Ad] Endereço:Department of Orthopedic Surgery, Faculty of Medicine, Minia University, Minia, Egypt.
[Ti] Título:Limited Open Quadriceps Release for Treatment of Congenital Dislocation of the Knee.
[So] Source:J Pediatr Orthop;37(3):192-198, 2017 Apr/May.
[Is] ISSN:1539-2570
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Congenital dislocation of the knee (CDK) is a rare condition for which the treatment is difficult and remains controversial. The aim of this case series is to evaluate the results of limited open quadriceps release for treatment of CDK. METHODS: Sixteen patients with CDK were managed at our institute from May 2006 to May 2014, and included 10 boys and 6 girls, with a mean age at presentation of 5 weeks (range, 1 to16 wk). Three patients who had an underlying neuromuscular syndrome were excluded. The remaining 13 patients had no identifiable syndrome. There were 9 bilateral cases and 4 unilateral, with a total of 22 dislocated knees. Treatment began with gentle manipulation and serial weekly long-leg plaster casting in the outpatient clinic. Limited open quadriceps release was performed after failure of conservative treatment or in cases that presented late (>12 wk). The mean follow-up was 26.8 months (range, 12 to 48 mo). RESULTS: Manipulation and serial casting were successful in 6 knees. The mean postmanipulation passive arc of range of motion of the affected knees was 118 degrees (range: 100 to 140 degrees). At final follow-up, the knee outcome was excellent in 2 knees and good in 4 knees. Sixteen knees were managed by limited open quadriceps release. The age of the patients at the time of surgery ranged between 8 and 16 weeks with a mean of 10 weeks. The mean postoperative passive arc of range of motion of the affected knees was 110 degrees (range: 95 to 145 degrees). Minor degrees of flexion deformity at the knee were encountered frequently (mean 8.5 degrees). Slight instability was observed in 6 cases. At final follow-up, the knee outcome was excellent in 6 knees and good in 10 knees. CONCLUSIONS: Management of CDK preferably should be started early with gentle manipulation and serial casting. Failure of conservative treatment or delayed presentation will need surgical intervention. Limited open quadriceps release has satisfactory results. LEVEL OF EVIDENCE: Level IV-case series.
[Mh] Termos MeSH primário: Luxação do Joelho/congênito
Luxação do Joelho/cirurgia
Procedimentos Ortopédicos/métodos
Músculo Quadríceps/cirurgia
[Mh] Termos MeSH secundário: Moldes Cirúrgicos
Feminino
Seguimentos
Seres Humanos
Lactente
Recém-Nascido
Articulação do Joelho/cirurgia
Deformidades Congênitas das Extremidades Inferiores/cirurgia
Masculino
Manipulação Ortopédica/métodos
Período Pós-Operatório
Amplitude de Movimento Articular
Tenotomia/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1097/BPO.0000000000000612


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[PMID]:28164238
[Au] Autor:Darwich R; Li W; Yamak A; Komati H; Andelfinger G; Sun K; Nemer M
[Ad] Endereço:Molecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, K1N 6N5, Canada.
[Ti] Título:KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
[So] Source:Hum Mol Genet;26(5):942-954, 2017 Mar 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:TBX5, a member of the T-box family of transcription factors, is a dosage sensitive regulator of heart development. Mutations in TBX5 are responsible for Holt-Oram Syndrome, an autosomal dominant disease with variable and partially penetrant cardiac defects suggestive of the existence of genetic and environmental modifiers. KLF13, a member of the Krüppel-like family of zinc finger proteins is co-expressed with TBX5 in several cardiac cells including atrial cardiomyocytes and cells of the interatrial septum. We report that KLF13 interacts physically and functionally with TBX5 to synergistically activate transcription of cardiac genes. We show that TBX5 contacts KLF13 via its T-domain and find that several disease-causing mutations therein have decreased KLF13 interaction. Whereas Klf13 heterozygote mice have no detectable cardiac defects, loss of a Klf13 allele in Tbx5 heterozygote mice significantly increases the penetrance of TBX5-dependent cardiac abnormalities including atrial, atrial-ventricular and ventricular septal defects. The results reveal for the first time combinatorial interaction between a T-box protein and a KLF family member and its importance for heart and possibly other organ development. The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/genética
Proteínas de Ciclo Celular/genética
Átrios do Coração/metabolismo
Cardiopatias Congênitas/genética
Comunicação Interatrial/genética
Fatores de Transcrição Kruppel-Like/genética
Deformidades Congênitas das Extremidades Inferiores/genética
Proteínas Repressoras/genética
Proteínas com Domínio T-Box/genética
Deformidades Congênitas das Extremidades Superiores/genética
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/metabolismo
Anormalidades Múltiplas/patologia
Animais
Proteínas de Ciclo Celular/metabolismo
Modelos Animais de Doenças
Regulação da Expressão Gênica
Átrios do Coração/patologia
Cardiopatias Congênitas/metabolismo
Cardiopatias Congênitas/patologia
Comunicação Interatrial/metabolismo
Comunicação Interatrial/patologia
Ventrículos do Coração/metabolismo
Ventrículos do Coração/patologia
Heterozigoto
Seres Humanos
Fatores de Transcrição Kruppel-Like/metabolismo
Deformidades Congênitas das Extremidades Inferiores/metabolismo
Deformidades Congênitas das Extremidades Inferiores/patologia
Camundongos
Mutação
Ligação Proteica
Domínios Proteicos/genética
Mapas de Interação de Proteínas/genética
Proteínas Repressoras/metabolismo
Proteínas com Domínio T-Box/metabolismo
Ativação Transcricional/genética
Deformidades Congênitas das Extremidades Superiores/metabolismo
Deformidades Congênitas das Extremidades Superiores/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (Klf13 protein, mouse); 0 (Kruppel-Like Transcription Factors); 0 (Repressor Proteins); 0 (T-Box Domain Proteins); 0 (T-box transcription factor 5)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170207
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx009


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[PMID]:28148674
[Au] Autor:Hughes A; Heidari N; Mitchell S; Livingstone J; Jackson M; Atkins R; Monsell F
[Ad] Endereço:Alfred Hospital, 55 Commercial Road, Melbourne, Australia.
[Ti] Título:Computer hexapod-assisted orthopaedic surgery provides a predictable and safe method of femoral deformity correction.
[So] Source:Bone Joint J;99-B(2):283-288, 2017 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Computer hexapod assisted orthopaedic surgery (CHAOS), is a method to achieve the intra-operative correction of long bone deformities using a hexapod external fixator before definitive internal fixation with minimally invasive stabilisation techniques. The aims of this study were to determine the reliability of this method in a consecutive case series of patients undergoing femoral deformity correction, with a minimum six-month follow-up, to assess the complications and to define the ideal group of patients for whom this treatment is appropriate. PATIENTS AND METHODS: The medical records and radiographs of all patients who underwent CHAOS for femoral deformity at our institution between 2005 and 2011 were retrospectively reviewed. Records were available for all 55 consecutive procedures undertaken in 49 patients with a mean age of 35.6 years (10.9 to 75.3) at the time of surgery. RESULTS: Patients were assessed at a mean interval of 44 months (6 to 90) following surgery. The indications were broad; the most common were vitamin D resistant rickets (n = 10), growth plate arrest (n = 6) and post-traumatic deformity (n = 20). Multi-planar correction was required in 33 cases. A single level osteotomy was performed in 43 cases. Locking plates were used to stabilise the osteotomy in 33 cases and intramedullary nails in the remainder. Complications included two nonunions, one death, one below-knee deep vein thrombosis, one deep infection and one revision procedure due to initial under-correction. There were no neurovascular injuries or incidence of compartment syndrome. CONCLUSION: This is the largest reported series of femoral deformity corrections using the CHAOS technique. This series demonstrates that precise intra-operative realignment is possible with a hexapod external fixator prior to definitive stabilisation with contemporary internal fixation. This combination allows reproducible correction of complex femoral deformity from a wide variety of diagnoses and age range with a low complication rate. Cite this article: Bone Joint J 2017;99-B:283-8.
[Mh] Termos MeSH primário: Fixadores Externos
Fêmur/cirurgia
Traumatismos da Perna/cirurgia
Deformidades Congênitas das Extremidades Inferiores/cirurgia
Cirurgia Assistida por Computador
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Criança
Feminino
Fêmur/anormalidades
Fêmur/diagnóstico por imagem
Fêmur/lesões
Fixação Interna de Fraturas
Seres Humanos
Traumatismos da Perna/diagnóstico
Deformidades Congênitas das Extremidades Inferiores/diagnóstico por imagem
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos
Osteotomia
Reprodutibilidade dos Testes
Estudos Retrospectivos
Cirurgia Assistida por Computador/instrumentação
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B2.BJJ-2016-0271.R1


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[PMID]:28148662
[Au] Autor:Xu J; Jia Y; Kang Q; Chai Y
[Ad] Endereço:Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
[Ti] Título:Intra-articular corrective osteotomies combined with the Ilizarov technique for the treatment of deformities of the knee.
[So] Source:Bone Joint J;99-B(2):204-210, 2017 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: To present our experience of using a combination of intra-articular osteotomy and external fixation to treat different deformities of the knee. PATIENTS AND METHODS: A total of six patients with a mean age of 26.5 years (15 to 50) with an abnormal hemi-joint line convergence angle (HJLCA) and mechanical axis deviation (MAD) were included. Elevation of a tibial hemiplateau or femoral condylar advancement was performed and limb lengthening with correction of residual deformity using a circular or monolateral Ilizarov frame. RESULTS: At a mean follow-up of 2.8 years (1.5 to 4.1), the mean HJLCA improved from 15.6° (10° to 23°) pre-operatively to 0.4° (0° to 2°). The mean MAD improved from 70.0 mm (20.1 to 118.5) pre-operatively to 9.1 mm (3 to 15). The mean tibiofemoral angle improved from 31.0° (8° to 54°) pre-operatively to 4.9° (2° to 8°). The mean limb-length discrepancy decreased from 6.3 cm (2.9 to 13.6) pre-operatively to 1.1 cm (0 to 5). All osteotomies and distraction zones healed without complications. CONCLUSION: The use of intra-articular corrective osteotomies combined with the Ilizarov technique allowed correction of deformities of the knee joint with satisfactory HJLCA and overall mechanical axis in six patients with a good functional and cosmetic outcome in the short term. Cite this article: Bone Joint J 2017;99-B:204-10.
[Mh] Termos MeSH primário: Técnica de Ilizarov
Deformidades Articulares Adquiridas/cirurgia
Articulação do Joelho/cirurgia
Deformidades Congênitas das Extremidades Inferiores/cirurgia
Osteotomia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170214
[Lr] Data última revisão:
170214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170203
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B2.BJJ-2016-0736.R2


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[PMID]:28074809
[Au] Autor:Rana M; Solanki SL; Agarwal V; Divatia JV
[Ad] Endereço:Department of Anesthesiology, Critical Care and Pain, Tata Memorial Hospital, Mumbai, Maharashtra, India.
[Ti] Título:Holt-Oram syndrome: Anesthetic challenges and safe outcome.
[So] Source:Ann Card Anaesth;20(1):110-111, 2017 Jan-Mar.
[Is] ISSN:0974-5181
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Holt-Oram syndrome (HOS) is an autosomal dominant disease with skeletal and cardiac manifestations. We here are presenting a 31-year-old man and a diagnosed case of HOS, with an ulceroproliferative lesion on lateral border of the tongue, was posted for wide excision of lesion with primary closure and left side radical neck dissection.
[Mh] Termos MeSH primário: Anestesia Intravenosa/métodos
Carcinoma de Células Escamosas/cirurgia
Cardiopatias Congênitas/complicações
Comunicação Interatrial/complicações
Deformidades Congênitas das Extremidades Inferiores/complicações
Bloqueio Neuromuscular/métodos
Neoplasias da Língua/cirurgia
Deformidades Congênitas das Extremidades Superiores/complicações
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/cirurgia
Adulto
Androstanóis
Anestésicos Intravenosos
Carcinoma de Células Escamosas/complicações
Fentanila
Cardiopatias Congênitas/cirurgia
Comunicação Interatrial/cirurgia
Seres Humanos
Deformidades Congênitas das Extremidades Inferiores/cirurgia
Masculino
Fármacos Neuromusculares não Despolarizantes
Propofol
Língua/cirurgia
Neoplasias da Língua/complicações
Deformidades Congênitas das Extremidades Superiores/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstanols); 0 (Anesthetics, Intravenous); 0 (Neuromuscular Nondepolarizing Agents); UF599785JZ (Fentanyl); WRE554RFEZ (rocuronium); YI7VU623SF (Propofol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.4103/0971-9784.197849


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[PMID]:28057264
[Au] Autor:Steimle JD; Moskowitz IP
[Ad] Endereço:University of Chicago, Chicago, IL, United States.
[Ti] Título:TBX5: A Key Regulator of Heart Development.
[So] Source:Curr Top Dev Biol;122:195-221, 2017.
[Is] ISSN:1557-8933
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:TBX5 is a member of the T-box transcription factor family and is primarily known for its role in cardiac and forelimb development. Human patients with dominant mutations in TBX5 are characterized by Holt-Oram syndrome, and show defects of the cardiac septa, cardiac conduction system, and the anterior forelimb. The range of cardiac defects associated with TBX5 mutations in humans suggests multiple roles for the transcription factor in cardiac development and function. Animal models demonstrate similar defects and have provided a useful platform for investigating the roles of TBX5 during embryonic development. During early cardiac development, TBX5 appears to act primarily as a transcriptional activator of genes associated with cardiomyocyte maturation and upstream of morphological signals for septation. During later cardiac development, TBX5 is required for patterning of the cardiac conduction system and maintenance of mature cardiomyocyte function. A comprehensive understanding of the integral roles of TBX5 throughout cardiac development and adult life will be critical for understanding human cardiac morphology and function.
[Mh] Termos MeSH primário: Coração/embriologia
Proteínas com Domínio T-Box/metabolismo
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/genética
Animais
Modelos Animais de Doenças
Redes Reguladoras de Genes
Haploinsuficiência/genética
Cardiopatias Congênitas/genética
Comunicação Interatrial/genética
Seres Humanos
Deformidades Congênitas das Extremidades Inferiores/genética
Proteínas com Domínio T-Box/genética
Deformidades Congênitas das Extremidades Superiores/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (T-Box Domain Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE


  9 / 292 MEDLINE  
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[PMID]:27426723
[Au] Autor:Su W; Zhu P; Wang R; Wu Q; Wang M; Zhang X; Mei L; Tang J; Kumar M; Wang X; Su L; Dong N
[Ad] Endereço:Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:Congenital heart diseases and their association with the variant distribution features on susceptibility genes.
[So] Source:Clin Genet;91(3):349-354, 2017 Mar.
[Is] ISSN:1399-0004
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Congenital heart disease (CHD), one of the causes of childhood morbidity and mortality, is mainly triggered by a combination of environmental and genetic factors. Several susceptible genes, such as NKX2-5, GATA4 and TBX5, have been reported as closely related to heart and vessel development. CHD subtypes are classified into diverse clinical phenotypes, such as atrial septal defects (ASD), ventricular septal defects (VSD), tetralogy of Fallot (TOF), and Holt-Oram syndrome (HOS). Here, we summarize the associations of the genetic variants in these three genes with CHD subtypes. CHD-associated variants of NKX2-5 locate mainly in the tinman domain and the homeodomain. Mutations in the homeodomain are correlated with ASD and atrioventricular (AV) block subtypes. VSD-associated variants of GATA4 are mainly at its terminal ends. Variants of TBX5 gene are primarily in exons 3, 4, 5 and 7 and highly associated with HOS subtype. Hence, the variant distribution of NKX2-5, GATA4 and TBX5 are tightly associated with particular CHD subtypes. Further structure-modelling analysis revealed that these mutated amino acid residuals maintain their DNA-binding ability and structural stability. Therefore structural features of these genes may be used to predict the high risk of CHD subtypes in infants.
[Mh] Termos MeSH primário: Fator de Transcrição GATA4/genética
Cardiopatias Congênitas/genética
Proteína Homeobox Nkx-2.5/genética
Proteínas com Domínio T-Box/genética
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/genética
Anormalidades Múltiplas/patologia
Estudos de Associação Genética
Predisposição Genética para Doença
Cardiopatias Congênitas/classificação
Cardiopatias Congênitas/patologia
Comunicação Interatrial/genética
Comunicação Interatrial/patologia
Comunicação Interventricular/genética
Comunicação Interventricular/patologia
Seres Humanos
Deformidades Congênitas das Extremidades Inferiores/genética
Deformidades Congênitas das Extremidades Inferiores/patologia
Mutação
Fenótipo
Tetralogia de Fallot/genética
Tetralogia de Fallot/patologia
Deformidades Congênitas das Extremidades Superiores/genética
Deformidades Congênitas das Extremidades Superiores/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (GATA4 Transcription Factor); 0 (GATA4 protein, human); 0 (Homeobox Protein Nkx-2.5); 0 (NKX2-5 protein, human); 0 (T-Box Domain Proteins); 0 (T-box transcription factor 5)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160719
[St] Status:MEDLINE
[do] DOI:10.1111/cge.12835


  10 / 292 MEDLINE  
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[PMID]:26356314
[Au] Autor:Ellis HB; Wise K; LaMont L; Copley L; Wilson P
[Ad] Endereço:*Department of Orthopaedic Surgery, University of Texas Southwestern, Children's Medical Center †Texas Scottish Rite Hospital for Children, Dallas ‡The University of Texas Medical Branch, Galveston, TX.
[Ti] Título:Prevalence of Discoid Meniscus During Arthroscopy for Isolated Lateral Meniscal Pathology in the Pediatric Population.
[So] Source:J Pediatr Orthop;37(4):285-292, 2017 Jun.
[Is] ISSN:1539-2570
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Meniscus tears in the young patient are becoming more prevalent. Knowledge of presenting characteristics and morphology can affect treatment decisions. The purpose of this study was to review and evaluate all the isolated lateral meniscus pathology that required arthroscopic treatment in a pediatric sports medicine practice and compare presenting characteristics between those with a discoid meniscus and those with normal meniscal morphology. METHODS: We performed a retrospective review of all isolated lateral meniscus arthroscopic procedures from 2003 to 2012 in a high-volume pediatric sports practice. Presentation, radiographs, and intraoperative findings were reviewed. The prevalence and clinical findings of a discoid meniscus in this population and among all age groups were compared with those with a meniscus tear occurring in a normal meniscus. RESULTS: Two hundred and sixty-one arthroscopies were performed for symptomatic isolated lateral menisci pathology. Of these, 75% were discoid in nature; the remainder was tears occurring in normal menisci. Ninety-six of 99 patients (97%) with lateral meniscus pathology under the age of 13 had a discoid meniscus and 66% presented with no injury. There was a transition within the population at 14 years of age, with a rise in the incidence of normal meniscal body tears. Even after this transition point, meniscal pathology incidence remained notable; 59% of isolated lateral meniscus pathology in patients between the ages of 14 and 16 years old were a discoid meniscus. Magnetic resonance imaging criteria for discoid meniscus (3 consecutive sagittal cuts or coronal mid-compartment measure) were unreliable after the age of 13 years old. The ratio of complete to incomplete discoids in all age groups was 4 to 3. CONCLUSIONS: In conclusion, discoid menisci have a high prevalence in isolated lateral meniscus pathology requiring knee arthroscopy. Clinical presentation, imaging, characteristics, and treatment may be different among different age groups. In the adolescent age group (14 to 16 y old), the presentation of a discoid meniscus may not be different from a meniscus tear with normal morphology. LEVEL OF EVIDENCE: Level III-diagnostic.
[Mh] Termos MeSH primário: Artroscopia/métodos
Deformidades Congênitas das Extremidades Inferiores/cirurgia
Meniscos Tibiais/anormalidades
Meniscos Tibiais/cirurgia
Lesões do Menisco Tibial/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Artralgia/epidemiologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Incidência
Articulação do Joelho/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Meniscos Tibiais/diagnóstico por imagem
Prevalência
Radiografia
Estudos Retrospectivos
Lesões do Menisco Tibial/diagnóstico por imagem
Lesões do Menisco Tibial/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150911
[St] Status:MEDLINE
[do] DOI:10.1097/BPO.0000000000000630



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