Base de dados : MEDLINE
Pesquisa : C05.799 [Categoria DeCS]
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[PMID]:28453121
[Au] Autor:Cabrera-Pivaral CE; Ramírez-García SA; Zavala-González MA
[Ad] Endereço:Health Sciences University Center, Universidad de Guadalajara. Guadalajara, Jalisco, Mexico. carlos_cabrera@prodigy.net.mx; zgma_51083@yahoo.com.mx.
[Ti] Título:Effect of an educational intervention on the clinical competence for primary healthcare of rheumatic diseases in Mexican physicians.
[So] Source:Rev Salud Publica (Bogota);18(5):808-815, 2016 Sep-Oct.
[Is] ISSN:0124-0064
[Cp] País de publicação:Colombia
[La] Idioma:eng
[Ab] Resumo:Objective : To measure the effect of an educational intervention on clinical competences for diagnosis and treatment of rheumatic diseases in primary healthcare physicians working in the Guadalajara Metropolitan Area, Jalisco, Mexico. Methodology: Quasi-experimental study conducted in physicians from two primary health care units. The study was carried out in a 40 physicians sample, 21 in Group "A" (intervention) and 19 in Group "B" (control). The clinical competence for diagnosis and treatment of rheumatic diseases was measured in both groups by means of an instrument previously designed and validated (Kuder-Richardson reliability index =0,94). Results: Clinical competence average score prior to intervention was 47 for Group "A" and 42 for Group "B", while after the intervention it was 72 and 47 respectively, which shows statistically significant differences (Wilcoxon test, p<0,05). Conclusions: Clinical competence for diagnosis and treatment of rheumatic diseases in primary healthcare physicians is low; however, it can be improved by implementing educational interventions based on a constructivist approach.
[Mh] Termos MeSH primário: Competência Clínica
Atenção Primária à Saúde
Doenças Reumáticas/diagnóstico
Doenças Reumáticas/terapia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
México
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29304089
[Au] Autor:Lin TM; Chen WS; Sheu JJ; Chen YH; Chen JH; Chang CC
[Ad] Endereço:Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
[Ti] Título:Autoimmune rheumatic diseases increase dementia risk in middle-aged patients: A nationwide cohort study.
[So] Source:PLoS One;13(1):e0186475, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Dementia is a common neurological disease that substantially affects public health. A previous study revealed that dementia occurs when the body's immune system attacks the cells of the brain, indicating that dementia may be similar to autoimmune rheumatic diseases (ARDs). In the current retrospective cohort study, we focused on middle-aged ARD patients (45 years or older) to investigate the association between ARDs in middle-aged people and dementia by using a nationwide population-based database in Taiwan. METHOD: Our study analyzed the medical data of the Taiwanese population from 2001 to 2012, with a follow-up period extending until the end of 2011. We identified middle-aged patients with ARDs by using the Taiwan National Health Insurance Research Database. We selected a comparison cohort from the general population that was randomly frequency-matched by age (in 5-year increments), sex, and index year and further analyzed the dementia risk by using a Cox regression model that considers sex, age, and comorbidities. RESULTS: The study enrolled 34,660 middle-aged ARD patients (77% female, mean age = 59.8 years) and 138,640 controls. The risk of developing dementia was 1.18 times higher for middle-aged patients with ARDs compared with patients without ARDs after adjustment for age, sex, and comorbidities. Among the patients with ARDs, the subgroups with rheumatoid arthritis, systemic lupus erythematosus, and Sjögren syndrome (SS) were associated with a significantly higher dementia risk (adjusted hazard ratio [HR] 1.14, 95% confidence index [CI] 1.06-1.32; adjusted HR 1.07, 95% CI 0.86-1.34; adjusted HR 1.46, 95% CI 1.32-1.63, respectively). Furthermore, primary SS and secondary SS patients had the highest risks of dementia among all the ADR subgroups (adjusted HR 1.35, 95% CI 1.18-1.54; adjusted HR 1.67, 95% CI 1.43-1.95 respectively). CONCLUSION: This nationwide retrospective cohort study demonstrated that dementia risk is significantly higher in middle-aged patients with ARDs compared with the general population.
[Mh] Termos MeSH primário: Doenças Autoimunes/epidemiologia
Demência/epidemiologia
Doenças Reumáticas/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Artrite Reumatoide/epidemiologia
Estudos de Coortes
Comorbidade
Feminino
Seres Humanos
Incidência
Lúpus Eritematoso Sistêmico/epidemiologia
Masculino
Meia-Idade
Estudos Retrospectivos
Fatores de Risco
Síndrome de Sjogren/epidemiologia
Taiwan/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186475


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[PMID]:29261752
[Au] Autor:Greenfield J; Hudson M; Vinet E; Fortin PR; Bykerk V; Pineau CA; Wang M; Bernatsky S; Baron M; Canadian Scleroderma Research Group and Canadian Inflammatory Myopathy Study Group
[Ad] Endereço:Department of Anatomy McGill University, Montréal, Quebec, Canada.
[Ti] Título:A comparison of health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARDs).
[So] Source:PLoS One;12(12):e0189840, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To compare physical and mental health-related quality of life (HRQoL) across four systemic autoimmune rheumatic diseases (SARD). METHODS: Incident subjects enrolled in four SARD cohorts, namely systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA) and idiopathic inflammatory myopathies (IIM) were studied. The outcomes of interest were baseline Short Form Health Survey physical (PCS) and mental (MCS) component summary scores. Multivariate analysis was conducted to determine whether PCS and MCS scores differed across SARD type. RESULTS: The study included 118 SLE (93% women, mean age 36 years), 108 SSc (79% women, mean age 55), 64 RA (63% women, mean age 58) and 25 IIM (68% women, mean age 49) subjects. Mean PCS scores were 38.9 ± 12.2 in SLE, 37.1 ± 13.3 in RA, 35.0 ± 13.6 in SSc and 28.0 ± 15.4 in IIM. Mean MCS scores were 45.0 ± 13.3 in RA, 44.4 ± 14.7 in SSc, 40.1 ± 14.3 in SLE and 33.6 ± 18.7 in IIM. SARD type was an independent predictor of HRQoL with, in some cases, the magnitude of the differences reaching one standard deviation (IIM worse PCS scores compared to SLE (ß -12.23 [95% CI -18.11, -6.36; p<0.001]); IIM worse MCS scores compared to SSc (ß -11.05 [95% CI -17.53, -4.58; p = 0.001]) and RA (ß -11.72 [95% CI -18.62, -4.81; p = 0.001]). CONCLUSIONS: Cross-SARD research provides a novel approach to gain greater understanding of commonalities and differences across rheumatic diseases. The differences observed warrant further research into correlates and trajectories over time.
[Mh] Termos MeSH primário: Doenças Autoimunes/patologia
Saúde
Qualidade de Vida
Doenças Reumáticas/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Modelos Lineares
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189840


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[PMID]:29190041
[Au] Autor:Koski J
[Ti] Título:Doppler imaging in inflammatory rheumatic diseases.
[So] Source:Duodecim;132(20):1882-9, 2016.
[Is] ISSN:0012-7183
[Cp] País de publicação:Finland
[La] Idioma:eng
[Ab] Resumo:Doppler imaging has increased in rheumatology during this millennium. The method can detect slow blood flow in inflamed synovium and soft tissues. Doppler imaging is more sensitive than clinical examination in the detection of joint inflammation. Ultrasound imaging combined with Doppler imaging is regarded as reference method in the evaluation of enthesitis,. Doppler imaging is an excellent tool in the diagnostics and follow up in the treatment of the inflammatory rheumatic diseases because it does not use radiation, can be performed bedside and repeated often. The adjustment of ultrasound and Doppler signal is machine specific.
[Mh] Termos MeSH primário: Doenças Reumáticas/diagnóstico por imagem
Ultrassonografia Doppler
[Mh] Termos MeSH secundário: Seres Humanos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


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[PMID]:27776789
[Au] Autor:Ammerlaan JW; van Os-Medendorp H; de Boer-Nijhof N; Maat B; Scholtus L; Kruize AA; Bijlsma JW; Geenen R
[Ad] Endereço:University Medical Center Utrecht, Department Rheumatology and Clinical Immunology, HPN D02.244, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. Electronic address: j.ammerlaan@umcutrecht.nl.
[Ti] Título:Preferences and needs of patients with a rheumatic disease regarding the structure and content of online self-management support.
[So] Source:Patient Educ Couns;100(3):501-508, 2017 Mar.
[Is] ISSN:1873-5134
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Aim of this study was to investigate preferences and needs regarding the structure and content of a person-centered online self-management support intervention for patients with a rheumatic disease. METHODS: A four step procedure, consisting of online focus group interviews, consensus meetings with patient representatives, card sorting task and hierarchical cluster analysis was used to identify the preferences and needs. RESULTS: Preferences concerning the structure involved 1) suitability to individual needs and questions, 2) fit to the life stage 3) creating the opportunity to share experiences, be in contact with others, 4) have an expert patient as trainer, 5) allow for doing the training at one's own pace and 6) offer a brief intervention. Hierarchical cluster analysis of 55 content needs comprised eleven clusters: 1) treatment knowledge, 2) societal procedures, 3) physical activity, 4) psychological distress, 5) self-efficacy, 6) provider, 7) fluctuations, 8) dealing with rheumatic disease, 9) communication, 10) intimate relationship, and 11) having children. CONCLUSION: A comprehensive assessment of preferences and needs in patients with a rheumatic disease is expected to contribute to motivation, adherence to and outcome of self-management-support programs. PRACTICE IMPLICATIONS: The overview of preferences and needs can be used to build an online-line self-management intervention.
[Mh] Termos MeSH primário: Internet
Determinação de Necessidades de Cuidados de Saúde
Doenças Reumáticas/terapia
Autocuidado/métodos
Autogestão
Apoio Social
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Preferência do Paciente
Doenças Reumáticas/psicologia
Autoeficácia
Grupos de Autoajuda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29255211
[Au] Autor:Schmidt RE; Grimbacher B; Witte T
[Ad] Endereço:Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg Straße 1, D-30625 Hannover, Germany.
[Ti] Título:Autoimmunity and primary immunodeficiency: two sides of the same coin?
[So] Source:Nat Rev Rheumatol;14(1):7-18, 2017 Dec 19.
[Is] ISSN:1759-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autoimmunity and immunodeficiency were previously considered to be mutually exclusive conditions; however, increased understanding of the complex immune regulatory and signalling mechanisms involved, coupled with the application of genetic analysis, is revealing the complex relationships between primary immunodeficiency syndromes and autoimmune diseases. Single-gene defects can cause rare diseases that predominantly present with autoimmune symptoms. Such genetic defects also predispose individuals to recurrent infections (a hallmark of immunodeficiency) and can cause primary immunodeficiencies, which can also lead to immune dysregulation and autoimmunity. Moreover, risk factors for polygenic rheumatic diseases often exist in the same genes as the mutations that give rise to primary immunodeficiency syndromes. In this Review, various primary immunodeficiency syndromes are presented, along with their pathogenetic mechanisms and relationship to autoimmune diseases, in an effort to increase awareness of immunodeficiencies that occur concurrently with autoimmune diseases and to highlight the need to initiate appropriate genetic tests. The growing knowledge of various genetically determined pathologic mechanisms in patients with immunodeficiencies who have autoimmune symptoms opens up new avenues for personalized molecular therapies that could potentially treat immunodeficiency and autoimmunity at the same time, and that could be further explored in the context of autoimmune rheumatic diseases.
[Mh] Termos MeSH primário: Doenças Autoimunes/imunologia
Autoimunidade/imunologia
Síndromes de Imunodeficiência/imunologia
Doenças Reumáticas/imunologia
[Mh] Termos MeSH secundário: Artrite Reumatoide/genética
Artrite Reumatoide/imunologia
Doenças Autoimunes/terapia
Autoimunidade/genética
Diagnóstico Diferencial
Doenças Genéticas Inatas/complicações
Doenças Genéticas Inatas/genética
Doenças Genéticas Inatas/imunologia
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla/métodos
Seres Humanos
Síndromes de Imunodeficiência/genética
Síndromes de Imunodeficiência/terapia
Lúpus Eritematoso Sistêmico/genética
Lúpus Eritematoso Sistêmico/imunologia
Terapia de Alvo Molecular/métodos
Mutação
Doenças Raras/genética
Doenças Reumáticas/genética
Doenças Reumáticas/terapia
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1038/nrrheum.2017.198


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[PMID]:29213125
[Au] Autor:Nishide M; Kumanogoh A
[Ad] Endereço:Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
[Ti] Título:The role of semaphorins in immune responses and autoimmune rheumatic diseases.
[So] Source:Nat Rev Rheumatol;14(1):19-31, 2018 Jan.
[Is] ISSN:1759-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Semaphorins have a well-characterized role in guiding axon repulsion during development; however, the important contribution of these proteins in immunity is becoming increasingly clear. Immunoregulatory semaphorins, termed 'immune semaphorins', have roles in regulating immune cell activation, differentiation, mobility and migration. These proteins are also intimately associated with the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This Review discusses the pathogenic functions of immune semaphorins, as well as the potential use of these molecules as diagnostic markers and therapeutic targets for the treatment of autoimmune diseases.
[Mh] Termos MeSH primário: Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/imunologia
Artrite Reumatoide/imunologia
Doenças Autoimunes/imunologia
Lúpus Eritematoso Sistêmico/imunologia
Doenças Reumáticas/imunologia
Escleroderma Sistêmico/imunologia
Semaforinas/imunologia
[Mh] Termos MeSH secundário: Animais
Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/fisiopatologia
Artrite Reumatoide/fisiopatologia
Doenças Autoimunes/fisiopatologia
Doenças Autoimunes/terapia
Biomarcadores/metabolismo
Seres Humanos
Lúpus Eritematoso Sistêmico/fisiopatologia
Camundongos
Polimorfismo de Nucleotídeo Único/genética
Doenças Reumáticas/fisiopatologia
Doenças Reumáticas/terapia
Escleroderma Sistêmico/fisiopatologia
Semaforinas/classificação
Semaforinas/genética
Semaforinas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Semaphorins)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1038/nrrheum.2017.201


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[PMID]:29216277
[Au] Autor:Latorre I; Mínguez S; Carrascosa JM; Naves J; Villar-Hernández R; Muriel B; Prat C; García-García E; Casas I; Domènech E; Ferrándiz C; Mateo L; Domínguez J
[Ad] Endereço:Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Institut d'Investigació Germans Trias i Pujol, Badalona, Spain.
[Ti] Título:Immune-mediated inflammatory diseases differently affect IGRAs' accuracy for latent tuberculosis infection diagnosis in clinical practice.
[So] Source:PLoS One;12(12):e0189202, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clinical accuracy of IGRAs remains unclear on patients with immune-mediated inflammatory diseases (IMIDs). Here, we assess the impact of immunosuppressants and IMIDs on QuantiFERON-TB Gold In-Tube (QFN-G-IT) and T-SPOT.TB accuracy. METHODS: Patients with IMIDs who required latent tuberculosis infection (LTBI) screening were enrolled and classified into: (i) 50 patients with inflammatory rheumatic diseases, (ii) 50 patients with psoriasis and (iii) 30 patients with Crohn's disease. A total of 44 healthy individuals without immunosuppression were also included as controls. Tuberculin skin test (TST), T-SPOT.TB and QFN-G-IT assays were performed. IGRAs were performed following manufacturer's instructions. RESULTS: Immunosuppressant's intake was more frequent on patients with Crohn's disease and psoriasis. Positive IGRAs and TST results were reduced in Crohn's disease patients, whereas rate of indeterminate T-SPOT.TB results was increased in this group with respect to the other IMIDs analysed and controls. When IFN-γ response was studied, the levels of this cytokine after mitogen stimulation were significantly lower in Crohn's and inflammatory rheumatic diseases than in psoriasis. Interestingly, psoriatic patients were the only ones not receiving corticosteroids. Furthermore, a negative correlation was observed between the IFN-γ secreted after mitogen stimulation and corticosteroids dose. CONCLUSIONS: IMIDs seem to negatively affect the clinical accuracy of IGRAs, being Crohn's disease patients the most affected individuals due to their concomitant drug-profile and impaired immune response.
[Mh] Termos MeSH primário: Testes de Liberação de Interferon-gama/normas
Tuberculose Latente/diagnóstico
Psoríase/complicações
Doenças Reumáticas/complicações
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Imunossupressores/uso terapêutico
Tuberculose Latente/complicações
Masculino
Meia-Idade
Psoríase/tratamento farmacológico
Doenças Reumáticas/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189202


  9 / 14618 MEDLINE  
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[PMID]:28792663
[Au] Autor:Bernhardt MB; De Guzman MM; Grimes A; Kirk S; Nelson S; Bergsbaken J; Minard CG; Despotovic JM
[Ad] Endereço:Department of Pharmacy, Texas Children's Hospital, Houston, Texas.
[Ti] Título:Rapid infusion of rituximab is well tolerated in children with hematologic, oncologic, and rheumatologic disorders.
[So] Source:Pediatr Blood Cancer;65(1), 2018 Jan.
[Is] ISSN:1545-5017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Traditional administration of rituximab requires careful titration and may involve many hours to minimize the risk of reactions. The objective of this study was to evaluate the safety of rapid infusions of rituximab in a pilot group of children with hematologic, oncologic, and rheumatologic disorders, and to determine the incidence of rate-related infusion reactions. Twenty patients enrolled in the study. All patients tolerated the rapid infusion of rituximab and no patient had an infusion-related reaction. We conclude that rapid infusions of rituximab are well tolerated and safe in our pilot group of patients.
[Mh] Termos MeSH primário: Doenças Hematológicas/tratamento farmacológico
Neoplasias/tratamento farmacológico
Doenças Reumáticas/tratamento farmacológico
Rituximab/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Projetos Piloto
Estudos Prospectivos
Rituximab/efeitos adversos
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1002/pbc.26759


  10 / 14618 MEDLINE  
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[PMID]:28978995
[Au] Autor:Tang Y; Zhou T; Yu X; Xue Z; Shen N
[Ad] Endereço:Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 145 Shan Dong Road (c), Shanghai 200001, China.
[Ti] Título:The role of long non-coding RNAs in rheumatic diseases.
[So] Source:Nat Rev Rheumatol;13(11):657-669, 2017 Nov.
[Is] ISSN:1759-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long non-coding RNAs (lncRNAs) have emerged as key epigenetic regulators that govern gene expression and influence multiple biological processes. Accumulating evidence demonstrates that lncRNAs have critical roles in immune cell development and function. In this Review, the molecular mechanisms of gene expression regulation by lncRNAs are described and current knowledge of the role of lncRNAs in immune regulation and inflammation are presented, highlighting strategies for defining the roles of lncRNAs in the pathogenesis of multiple rheumatic diseases. Finally, research progress in understanding the role of lncRNAs in rheumatic diseases is discussed.
[Mh] Termos MeSH primário: Regulação da Expressão Gênica
RNA Longo não Codificante/genética
Doenças Reumáticas/genética
[Mh] Termos MeSH secundário: Biomarcadores/metabolismo
Epigênese Genética
Seres Humanos
RNA Longo não Codificante/biossíntese
Doenças Reumáticas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (RNA, Long Noncoding)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1038/nrrheum.2017.162



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