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[PMID]: 29480863 [Au] Autor: Wu TC; Wu KL; Hu WL; Sheen JM; Lu CN; Chiang JY; Hung YC [Ad] Endereço: Department of Chinese Medicine. [Ti] Título: Tongue diagnosis indices for upper gastrointestinal disorders: Protocol for a cross-sectional, case-controlled observational study. [So] Source: Medicine (Baltimore);97(2):e9607, 2018 Jan. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Upper gastrointestinal disorders are common in clinical practice, for example, gastritis, peptic ulcer disease, and gastroesophageal reflux disease. Panendoscopy or upper gastrointestinal endoscopy is viewed as the primary tool for examining the upper gastrointestinal mucosa, and permitting biopsy and endoscopic therapy. Although panendoscopy is considered to be a safe procedure with minimal complications, there are still some adverse effects, and patients are often anxious about undergoing invasive procedures. Traditional Chinese medicine tongue diagnosis plays an important role in differentiation of symptoms because the tongue reflects the physiological and pathological condition of the body. The automatic tongue diagnosis system (ATDS), which noninvasively captures tongue images, can provide objective and reliable diagnostic information. METHODS: This protocol is a cross-sectional, case-controlled observational study investigating the usefulness of the ATDS in clinical practice by examining its efficacy as a diagnostic tool for upper gastrointestinal disorders. Volunteers over 20 years old with and without upper gastrointestinal symptoms will be enrolled. Tongue images will be captured and the patients divided into 4 groups according to their panendoscopy reports, including a gastritis group, peptic ulcer disease group, gastroesophageal reflux disease group, and healthy group. Nine primary tongue features will be extracted and analyzed, including tongue shape, tongue color, tooth mark, tongue fissure, fur color, fur thickness, saliva, ecchymosis, and red dots. OBJECTIVES: The aim of this protocol is to apply a noninvasive ATDS to evaluate tongue manifestations of patients with upper gastrointestinal disorders and examine its efficacy as a diagnostic tool. [Mh] Termos MeSH primário: Doenças do Sistema Digestório/diagnóstico Medicina Tradicional Chinesa Língua [Mh] Termos MeSH secundário: Estudos de Casos e Controles Estudos Transversais Doenças do Sistema Digestório/patologia Medicina Tradicional Chinesa/instrumentação Medicina Tradicional Chinesa/métodos Reconhecimento Automatizado de Padrão Língua/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180227 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009607

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[PMID]: 29215478 [Au] Autor: Smith SR; Murray D; Pockney PG; Bendinelli C; Draganic BD; Carroll R [Ad] Endereço: Department of Colorectal Surgery, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia. [Ti] Título: Tranexamic Acid for Lower GI Hemorrhage: A Randomized Placebo-Controlled Clinical Trial. [So] Source: Dis Colon Rectum;61(1):99-106, 2018 Jan. [Is] ISSN: 1530-0358 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions. Information regarding the use of tranexamic acid in treating lower GI hemorrhage is lacking. OBJECTIVE: The aim of this trial was to determine the clinical efficacy of tranexamic acid when used for lower GI hemorrhage. DESIGN: This was a prospective, double-blind, placebo-controlled, randomized clinical trial. SETTINGS: The study was conducted at a tertiary referral university hospital in Australia. PATIENTS: Consecutive patients aged >18 years with lower GI hemorrhage requiring hospital admission from November 2011 to January 2014 were screened for trial eligibility (N = 265). INTERVENTIONS: A total of 100 patients were recruited after exclusions and were randomly assigned 1:1 to either tranexamic acid or placebo. MAIN OUTCOME MEASURES: The primary outcome was blood loss as determined by reduction in hemoglobin levels. The secondary outcomes were transfusion rates, transfusion volume, intervention rates for bleeding, length of hospital stay, readmission, and complication rates. RESULTS: There was no difference between groups with respect to hemoglobin drop (11 g/L of tranexamic acid vs 13 g/L of placebo; p = 0.9445). There was no difference with respect to transfusion rates (14/49 tranexamic acid vs 16/47 placebo; p = 0.661), mean transfusion volume (1.27 vs 1.93 units; p = 0.355), intervention rates (7/49 vs 13/47; p = 0.134), length of hospital stay (4.67 vs 4.74 d; p = 0.934), readmission, or complication rates. No complications occurred as a direct result of tranexamic acid use. LIMITATIONS: A larger multicenter trial may be required to determine whether there are more subtle advantages with tranexamic acid use in some of the secondary outcomes. CONCLUSIONS: Tranexamic acid does not appear to decrease blood loss or improve clinical outcomes in patients presenting with lower GI hemorrhage in the context of this trial. see Video Abstract at http://links.lww.com/DCR/A453. [Mh] Termos MeSH primário: Antifibrinolíticos/uso terapêutico Doenças do Sistema Digestório/complicações Hemorragia Gastrointestinal/tratamento farmacológico Ácido Tranexâmico/uso terapêutico [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Método Duplo-Cego Feminino Hemorragia Gastrointestinal/etiologia Seres Humanos Masculino Meia-Idade Estudos Prospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Antifibrinolytic Agents); 6T84R30KC1 (Tranexamic Acid) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171215 [Lr] Data última revisão: 171215 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171208 [St] Status: MEDLINE [do] DOI: 10.1097/DCR.0000000000000943

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[PMID]: 28786475 [Au] Autor: Meehan E; Williams K; Reid SM; Freed GL; Babl FE; Sewell JR; Vidmar S; Donath S; Reddihough DS [Ad] Endereço: Developmental Disability and Rehabilitation Research, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia. [Ti] Título: Comparing emergency department presentations among children with cerebral palsy with general childhood presentations: a data linkage study. [So] Source: Dev Med Child Neurol;59(11):1188-1195, 2017 Nov. [Is] ISSN: 1469-8749 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: AIM: The aims of this study were to estimate the proportion of emergency department presentations attributable to children with cerebral palsy (CP), investigate the frequency of emergency department presentations in a CP cohort, and compare emergency department presentations among children with CP with those of other children. METHOD: This was a retrospective cohort study. The Victorian Cerebral Palsy Register was linked to the Victorian Emergency Minimum Dataset. Data on emergency department presentations for the CP cohort occurring between 2007 and 2014 and population control data were obtained. RESULTS: The CP cohort (n=1748) had 7015 emergency department presentations during the 7-year period, accounting for 0.4% of the 1.69 million age-specific presentations during that time. The number of annual presentations per 1000 children rose with increasing CP severity. Compared with presentations among the general population, higher proportions of presentations among the CP cohort were preceded by ambulance arrivals (27% vs 8%), triaged as urgent (66% vs 32%), and required hospital admission (38% vs 12%). INTERPRETATION: The marked differences in presentations between the CP cohort and the general population in the proportions that were urgent and required ambulance arrivals and hospital admissions was an important finding. Strategies to ensure appropriate use of services, including encouragement to seek earlier assistance from primary care providers, may prevent problems escalating to the need for urgent care. WHAT THIS PAPER ADDS: Children with cerebral palsy (CP) account for 0.4% of childhood emergency department presentations. More emergency department presentations among children with CP require ambulance arrival. More CP emergency department presentations are urgent and require hospital admission. Traditional emergency department triage scales seem less accurate for this group. [Mh] Termos MeSH primário: Paralisia Cerebral/epidemiologia Paralisia Cerebral/terapia Serviço Hospitalar de Emergência/estatística & dados numéricos Hospitais Pediátricos/estatística & dados numéricos [Mh] Termos MeSH secundário: Adolescente Paralisia Cerebral/complicações Criança Pré-Escolar Estudos de Coortes Doenças do Sistema Digestório/etiologia Feminino Seres Humanos Masculino Doenças Musculoesqueléticas/etiologia Doenças do Sistema Nervoso/etiologia Nova Zelândia/epidemiologia Sistema de Registros Transtornos Respiratórios/etiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171030 [Lr] Data última revisão: 171030 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170809 [St] Status: MEDLINE [do] DOI: 10.1111/dmcn.13518

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[PMID]: 28693038 [Au] Autor: Gunter MJ; Murphy N; Cross AJ; Dossus L; Dartois L; Fagherazzi G; Kaaks R; Kühn T; Boeing H; Aleksandrova K; Tjønneland A; Olsen A; Overvad K; Larsen SC; Redondo Cornejo ML; Agudo A; Sánchez Pérez MJ; Altzibar JM; Navarro C; Ardanaz E; Khaw KT; Butterworth A; Bradbury KE; Trichopoulou A; Lagiou P; Trichopoulos D; Palli D; Grioni S; Vineis P; Panico S; Tumino R; Bueno-de-Mesquita B; Siersema P; Leenders M; Beulens JWJ; Uiterwaal CU; Wallström P; Nilsson LM; Landberg R; Weiderpass E; Skeie G; Braaten T; Brennan P; Licaj I; Muller DC; Sinha R; Wareham N; Riboli E [Ad] Endereço: From International Agency for Research on Cancer, Lyon, France; Imperial College London, London, United Kingdom; Institut Gustave Roussy, Villejuif, France; German Cancer Research Center, Heidelberg, Germany; German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Danish Cancer So [Ti] Título: Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study. [So] Source: Ann Intern Med;167(4):236-247, 2017 Aug 15. [Is] ISSN: 1539-3704 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Background: The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective: To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design: Prospective cohort study. Setting: 10 European countries. Participants: 521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements: Hazard ratios (HRs) and 95% CIs estimated using multivariable Cox proportional hazards models. The association of coffee consumption with serum biomarkers of liver function, inflammation, and metabolic health was evaluated in the EPIC Biomarkers subcohort (n = 14 800). Results: During a mean follow-up of 16.4 years, 41 693 deaths occurred. Compared with nonconsumers, participants in the highest quartile of coffee consumption had statistically significantly lower all-cause mortality (men: HR, 0.88 [95% CI, 0.82 to 0.95]; P for trend < 0.001; women: HR, 0.93 [CI, 0.87 to 0.98]; P for trend = 0.009). Inverse associations were also observed for digestive disease mortality for men (HR, 0.41 [CI, 0.32 to 0.54]; P for trend < 0.001) and women (HR, 0.60 [CI, 0.46 to 0.78]; P for trend < 0.001). Among women, there was a statistically significant inverse association of coffee drinking with circulatory disease mortality (HR, 0.78 [CI, 0.68 to 0.90]; P for trend < 0.001) and cerebrovascular disease mortality (HR, 0.70 [CI, 0.55 to 0.90]; P for trend = 0.002) and a positive association with ovarian cancer mortality (HR, 1.31 [CI, 1.07 to 1.61]; P for trend = 0.015). In the EPIC Biomarkers subcohort, higher coffee consumption was associated with lower serum alkaline phosphatase; alanine aminotransferase; aspartate aminotransferase; γ-glutamyltransferase; and, in women, C-reactive protein, lipoprotein(a), and glycated hemoglobin levels. Limitations: Reverse causality may have biased the findings; however, results did not differ after exclusion of participants who died within 8 years of baseline. Coffee-drinking habits were assessed only once. Conclusion: Coffee drinking was associated with reduced risk for death from various causes. This relationship did not vary by country. Primary Funding Source: European Commission Directorate-General for Health and Consumers and International Agency for Research on Cancer. [Mh] Termos MeSH primário: Café Ingestão de Líquidos/etnologia Mortalidade [Mh] Termos MeSH secundário: Adulto Biomarcadores/sangue Doenças Cardiovasculares/mortalidade Causas de Morte Transtornos Cerebrovasculares/mortalidade Doenças do Sistema Digestório/mortalidade Europa (Continente)/epidemiologia Feminino Seres Humanos Inflamação/sangue Testes de Função Hepática Masculino Meia-Idade Neoplasias Ovarianas/mortalidade Modelos de Riscos Proporcionais Estudos Prospectivos Fatores de Risco [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Coffee) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170822 [Lr] Data última revisão: 170822 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170711 [St] Status: MEDLINE [do] DOI: 10.7326/M16-2945

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[PMID]: 28603200 [Au] Autor: Tadano H; Torigoe T [Ad] Endereço: Department of Pathology, Sapporo Medical University School of Medicine. [Ti] Título: Immune-related adverse events of immune checkpoint inhibitors. [So] Source: Nihon Rinsho Meneki Gakkai Kaishi;40(2):102-108, 2017. [Is] ISSN: 1349-7413 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Development and application of anti-CTLA-4 antibody and anti-PD-1 antibody to cancer immunotherapy brought great survival benefits to advanced cancer patients. They have been applied to various cancers such as melanoma, non-small cell lung cancer, renal cell cancer, Hodgkin's disease, and head and neck cancers, and there is no doubt that immunotherapy is becoming a standard therapy as well as surgery, chemotherapy, and radiotherapy. On the other hand, immune-related adverse events (irAEs) have been increasingly reported. Nevertheless, mechanisms of the immune-mediated toxicities are still unclear. There has been a growing interest in the elucidation of the mechanisms. This review describes the general characteristics of irAEs induced by immune checkpoint inhibitors, especially 1. Heterogeneity, 2. Multiplicity, 3. Durability, and 4. Correlativity. [Mh] Termos MeSH primário: Anticorpos Monoclonais/efeitos adversos Imunoterapia/efeitos adversos Neoplasias/tratamento farmacológico [Mh] Termos MeSH secundário: Animais Anticorpos Monoclonais/uso terapêutico Antígeno CTLA-4/imunologia Doenças do Sistema Digestório/etiologia Doenças do Sistema Endócrino/etiologia Seres Humanos Ipilimumab Hepatopatias/etiologia Doenças Pulmonares Intersticiais/etiologia Camundongos Receptor de Morte Celular Programada 1/imunologia Dermatopatias/etiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antibodies, Monoclonal); 0 (CTLA-4 Antigen); 0 (Ipilimumab); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 31YO63LBSN (nivolumab) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170613 [St] Status: MEDLINE [do] DOI: 10.2177/jsci.40.102

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[PMID]: 28480844 [Au] Autor: Bacheva I; Umbetalina N; Bregvadze-Tabagari N; Shalygina A; Baidildina B [Ad] Endereço: Karaganda State Medical University, Kazakhstan; D. Tvildiani Medical University, Tbilisi, Georgia. [Ti] Título: [EPIDEMIOLOGY, STRUCTURE AND ALGORITHM OF MANAGEMENT OF PREGNANT WOMEN WITH EXTRAGENITAL PATHOLOGY OF THERAPEUTIC PROFILE]. [So] Source: Georgian Med News;(264):25-31, 2017 Mar. [Is] ISSN: 1512-0112 [Cp] País de publicação: Georgia (Republic) [La] Idioma: rus [Ab] Resumo: Purpose of the study - the study of the extragenital pathology (EGP) structure in pregnant women according to the requests for medical help. The screening survey was attended by 742 pregnant women. Average age was 28,4±5,5 years. A retrospective analysis of the causes of calls to pregnant ambulance carriages was carried out for 2012-2013. On the basis of obtained data was suggested an algorithm of pregnant women with EGP management. In the structure of EGP in one profile led hematology - 306 cases (41.2%), followed by nephrology - 290 (39.1%) and gastroenterology (38.8%) - 288 cases, respectively. In the structure of requests for emergency medical care for pregnant first place occupied by respiratory diseases (2012 r - 28%, 2013- 30%), followed by urinary system diseases (2012 - 19.6% 2013 - 17.2% r ). Obtained data formed the basis for the algorithm to identify risks and provide medical care for pregnant women with extragenital pathology. In the structure of the screening study prevailed hematology profile diseases, and respiratory system diseases often were the reason for emergency medical care. The result of this study became the creating of the algorithm for medical care delivery. [Mh] Termos MeSH primário: Complicações na Gravidez/epidemiologia [Mh] Termos MeSH secundário: Adulto Estudos Transversais Doenças do Sistema Digestório/epidemiologia Doenças do Sistema Endócrino/epidemiologia Feminino Seres Humanos Gravidez Complicações Cardiovasculares na Gravidez/epidemiologia Complicações Hematológicas na Gravidez/epidemiologia Prevalência Doenças Respiratórias/epidemiologia Estudos Retrospectivos Risco Doenças Urológicas/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170808 [Lr] Data última revisão: 170808 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170509 [St] Status: MEDLINE

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[PMID]: 28474959 [Au] Autor: Rotsides JM; Krakovsky GM; Pillai DK; Sehgal S; Collins ME; Noelke CE; Bauman NM [Ad] Endereço: 1 George Washington University School of Medicine and Health Sciences, Washington, DC, USA. [Ti] Título: Is a Multidisciplinary Aerodigestive Clinic More Effective at Treating Recalcitrant Aerodigestive Complaints Than a Single Specialist? [So] Source: Ann Otol Rhinol Laryngol;126(7):537-543, 2017 Jul. [Is] ISSN: 1943-572X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To determine the utility of a pediatric multidisciplinary aerodigestive clinic (ADC) in treating recalcitrant aerodigestive conditions. METHODS: Longitudinal observational study of presenting complaints, evaluation, management, and outcome of patients seen during 12 monthly ADCs beginning August 2013. RESULTS: Fifty-five patients were seen by the ADC team (otolaryngology/gastroenterology/pulmonology/speech pathology/nurse practitioner) and followed for a mean 17.6 months (range, 12-26 months). Mean age was 4.3 years (range, 0.5-19 years). All were seen by at least 1 specialist before ADC referral but without significant improvement. Chronic cough was the most common primary symptom (44%). Clinic evaluation included flexible nasopharyngolaryngoscopy (FFL, 53%) and pulmonary function testing (36%.) FFL influenced management in 79%. An operative procedure usually combined endoscopy was warranted in 58%. Endoscopy provided high diagnostic yield, detecting laryngeal cleft (8), adenoid hypertrophy (8), vocal cord dysfunction (4), pulmonary infection (4), reflux disease (3), laryngomalacia (3), tracheomalacia (2), cilia abnormality (2), celiac disease (1), Helicobacter pylori (1), duodenal web (1), and eosinophilic esophagitis (1). Outcome was available for 48 of 55 patients, with 73% reporting resolved to markedly improved symptoms and 27% minimal to no improvement. CONCLUSIONS: The ADC team approach resulted in resolved to markedly improved symptoms in 73% of patients whose symptoms persisted despite seeing a single specialist prior to referral. [Mh] Termos MeSH primário: Doenças do Sistema Digestório/diagnóstico Doenças do Sistema Digestório/terapia Comunicação Interdisciplinar Equipe de Assistência ao Paciente Doenças Respiratórias/diagnóstico Doenças Respiratórias/terapia [Mh] Termos MeSH secundário: Adolescente Criança Pré-Escolar Feminino Seguimentos Seres Humanos Lactente Masculino Encaminhamento e Consulta Estudos Retrospectivos Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170821 [Lr] Data última revisão: 170821 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170506 [St] Status: MEDLINE [do] DOI: 10.1177/0003489417708579

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[PMID]: 28397559 [Au] Autor: Mudd PA; Silva AL; Callicott SS; Bauman NM [Ad] Endereço: 1 Department of Otolaryngology, Head and Neck Surgery, Children's National Health Services, Washington, DC, USA. [Ti] Título: Cost Analysis of a Multidisciplinary Aerodigestive Clinic: Are Such Clinics Financially Feasible? [So] Source: Ann Otol Rhinol Laryngol;126(5):401-406, 2017 May. [Is] ISSN: 1943-572X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: Multidisciplinary clinics offer important value to pediatric patients with complex conditions that overlap specialties; however, such labor-intensive clinics are difficult to facilitate. We performed a cost analysis of our pediatric multidisciplinary aerodigestive clinic (MADC) to assess its financial feasibility at our tertiary care institution. METHOD: Revenue was based on net collections for clinic, professional, and hospital setting charges generated during 12 consecutive monthly MADCs beginning August 2013. Clinic charges included facility and speech pathologist fees. Professional charges included clinic and operative fees generated by providers and anesthesiologist. Hospital setting fees included facility and material charges for technical procedures. Direct expense calculations included all providers and staff salaries, benefits, and supply costs. RESULTS: Charge capture for 54 consecutive patients seen during the study time included new visits 99203-99205 (n = 63), consults 99243-99245 (n = 60), and follow-up visits 99212-99215 (n = 196). Sixty percent of patients underwent a clinic nasopharyngeal or laryngeal endoscopy (92511 or 31575), and 60% underwent subsequent intraoperative procedures with 1 (n = 8) or 2 to 3 services (n = 24). Program net revenue totaled $828 136 and direct costs $518 867, accounting for a net positive margin of $309 269. CONCLUSIONS: When including direct downstream revenue, our MADC operates on a net positive margin, making it financially feasible. [Mh] Termos MeSH primário: Doenças do Sistema Digestório Pediatria Doenças Respiratórias Centros de Atenção Terciária [Mh] Termos MeSH secundário: Criança Análise Custo-Benefício Doenças do Sistema Digestório/diagnóstico Doenças do Sistema Digestório/terapia Estudos de Viabilidade Seres Humanos Equipe de Assistência ao Paciente/economia Equipe de Assistência ao Paciente/organização & administração Pediatria/economia Pediatria/métodos Doenças Respiratórias/diagnóstico Doenças Respiratórias/terapia Estudos Retrospectivos Centros de Atenção Terciária/economia Centros de Atenção Terciária/organização & administração Centros de Atenção Terciária/estatística & dados numéricos Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170418 [Lr] Data última revisão: 170418 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170412 [St] Status: MEDLINE [do] DOI: 10.1177/0003489417699420

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[PMID]: 28366734 [Au] Autor: Kim CK; He P; Bialkowska AB; Yang VW [Ad] Endereço: Department of Medicine, Stony Brook University School of Medicine, Stony Brook, New York. [Ti] Título: SP and KLF Transcription Factors in Digestive Physiology and Diseases. [So] Source: Gastroenterology;152(8):1845-1875, 2017 Jun. [Is] ISSN: 1528-0012 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription factors that contain conserved zinc finger domains involved in binding to target DNA sequences. Many of these proteins are expressed in different tissues and have distinct tissue-specific activities and functions. Studies have shown that SPs and KLFs regulate not only physiological processes such as growth, development, differentiation, proliferation, and embryogenesis, but pathogenesis of many diseases, including cancer and inflammatory disorders. Consistently, these proteins have been shown to regulate normal functions and pathobiology in the digestive system. We review recent findings on the tissue- and organ-specific functions of SPs and KLFs in the digestive system including the oral cavity, esophagus, stomach, small and large intestines, pancreas, and liver. We provide a list of agents under development to target these proteins. [Mh] Termos MeSH primário: Doenças do Sistema Digestório/metabolismo Sistema Digestório/metabolismo Fatores de Transcrição Kruppel-Like/metabolismo Fatores de Transcrição Sp/metabolismo [Mh] Termos MeSH secundário: Animais Sistema Digestório/patologia Sistema Digestório/fisiopatologia Doenças do Sistema Digestório/genética Doenças do Sistema Digestório/patologia Doenças do Sistema Digestório/fisiopatologia Regulação da Expressão Gênica Seres Humanos Fatores de Transcrição Kruppel-Like/genética Transdução de Sinais Fatores de Transcrição Sp/genética [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Kruppel-Like Transcription Factors); 0 (Sp Transcription Factors) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170814 [Lr] Data última revisão: 170814 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170404 [St] Status: MEDLINE

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[PMID]: 28360031 [Au] Autor: Omary MB [Ad] Endereço: Department of Molecular and Integrative Physiology and Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. [Ti] Título: Intermediate filament proteins of digestive organs: physiology and pathophysiology. [So] Source: Am J Physiol Gastrointest Liver Physiol;312(6):G628-G634, 2017 Jun 01. [Is] ISSN: 1522-1547 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Intermediate filament proteins (IFs), such as cytoplasmic keratins in epithelial cells and vimentin in mesenchymal cells and the nuclear lamins, make up one of the three major cytoskeletal protein families. Whether in digestive organs or other tissues, IFs share several unique features including stress-inducible overexpression, abundance, cell-selective and differentiation state expression, and association with >80 human diseases when mutated. Whereas most IF mutations cause disease, mutations in simple epithelial keratins 8, 18, or 19 or in lamin A/C predispose to liver disease with or without other tissue manifestations. Keratins serve major functions including protection from apoptosis, providing cellular and subcellular mechanical integrity, protein targeting to subcellular compartments, and scaffolding and regulation of cell-signaling processes. Keratins are essential for Mallory-Denk body aggregate formation that occurs in association with several liver diseases, whereas an alternate type of keratin and lamin aggregation occurs upon liver involvement in porphyria. IF-associated diseases have no known directed therapy, but high-throughput drug screening to identify potential therapies is an appealing ongoing approach. Despite the extensive current knowledge base, much remains to be discovered regarding IF physiology and pathophysiology in digestive and nondigestive organs. [Mh] Termos MeSH primário: Doenças do Sistema Digestório/metabolismo Sistema Digestório/metabolismo Proteínas de Filamentos Intermediários/metabolismo Filamentos Intermediários/metabolismo [Mh] Termos MeSH secundário: Animais Sistema Digestório/patologia Sistema Digestório/fisiopatologia Doenças do Sistema Digestório/genética Doenças do Sistema Digestório/patologia Doenças do Sistema Digestório/fisiopatologia Regulação da Expressão Gênica Predisposição Genética para Doença Seres Humanos Proteínas de Filamentos Intermediários/genética Filamentos Intermediários/genética Filamentos Intermediários/patologia Corpos de Mallory/metabolismo Corpos de Mallory/patologia Mutação Fenótipo Polimorfismo Genético [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Intermediate Filament Proteins) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170401 [St] Status: MEDLINE [do] DOI: 10.1152/ajpgi.00455.2016

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