Base de dados : MEDLINE
Pesquisa : C06.198.025 [Categoria DeCS]
Referências encontradas : 347 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 35 ir para página                         

  1 / 347 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28501111
[Au] Autor:Wang C; Diao M; Li L; Liu S; Chen Z; Li X; Cheng W
[Ad] Endereço:Department of Colorectum Surgery, Qingdao Municipal Hospital, Qingdao, People's Republic of China; Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China.
[Ti] Título:Laparoscopic dissection and division of distal fistula in boys with rectourethral fistula.
[So] Source:J Surg Res;211:147-153, 2017 May 01.
[Is] ISSN:1095-8673
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Congenital rectourethral fistula (RUF) is the most common form of anorectal malformations found in boys. The aim of this study is to review our experience with dissection and division of distal fistula using laparoscopic surgery in the management of RUF, especially rectourethral bulbar fistula. METHODS: One hundred and two consecutive boys with congenital RUF who underwent conventional or single-incision laparoscopic surgery between July 2008 and June 2015 were enrolled in the study. The dissection of the distal fistula was performed along submucosal layer to a level 0.5 cm proximal to the urethra. Rectal mucosa of the fistula was dissected to the distal most point and completely transected flush with the posterior urethra. The residual muscular cuff was ligated with Hem-o-Lock clip or 5-0 PDS suture. Voiding cystourethrography and pelvic magnetic resonance imaging were performed at 3 mo, 6 mo, and 1 y postoperatively. RESULTS: All patients successfully underwent laparoscopic surgery without conversion. The mean age at the time of operation was 4.3 ± 2.9 mo. The operative times for the rectoprostatic fistula and rectobulbar fistula were similar (118.2 versus 119.4 min, P = 0.082). There was no significant difference in average operative time between conventional laparoscopic surgery group and single-incision laparoscopic surgery group (118.8 versus 119.1 min, P = 0.281). There was no injury to the urethra or vas deferens. The urethral catheter was removed on postoperative day 10. All patients were followed up. The median follow-up period was 3.3 ± 1.8 y. No recurrent fistula or urethral diverticulum was detected on voiding cystourethrography and pelvic MRI at 1 y. CONCLUSIONS: Submucosal dissection and division of distal fistula using a laparoscopic approach is safe, feasible, and effective for congenital RUF, especially bulbar fistula, in boys.
[Mh] Termos MeSH primário: Malformações Anorretais/cirurgia
Laparoscopia/métodos
Fístula Retal/cirurgia
Doenças Uretrais/cirurgia
Fístula Urinária/cirurgia
[Mh] Termos MeSH secundário: Seguimentos
Seres Humanos
Lactente
Recém-Nascido
Masculino
Fístula Retal/congênito
Estudos Retrospectivos
Resultado do Tratamento
Doenças Uretrais/congênito
Fístula Urinária/congênito
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170515
[St] Status:MEDLINE


  2 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28260053
[Au] Autor:Geng Y; Mi J; Gao H; Jia H; Wang W
[Ad] Endereço:Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
[Ti] Título:Spatiotemporal expression of Wnt3a during striated muscle complex development in rat embryos with ethylenethiourea-induced anorectal malformations.
[So] Source:Mol Med Rep;15(4):1601-1606, 2017 Apr.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Numerous patients with anorectal malformations (ARMs) continue to experience fecal incontinence and constipation following surgical procedures. One of the most important factors that influences defecation is the striated muscle complex (SMC). Wnt signaling regulates the expression of myogenic regulatory factors, which serve an important role in muscle development. Therefore, the present study aimed to investigate the expression pattern of Wnt3a protein (by immunohistochemistry and western blot analysis) and mRNA [by reverse transcription­quantitative polymerase chain reaction (RT-qPCR)] in the SMC of ARM model rats that were exposed to ethylenethiourea. Immunostaining revealed that the expression of Wnt3a exhibits space­ and time­dependent changes in the developing SMC of ARM model rat embryos. Immunohistochemistry demonstrated that on embryonic day 17 (E17), Wnt3a­positive cells were observed in the SMC in normal embryos, and expression levels gradually increased as the rat embryos developed. Similar changes in Wnt3a protein expression were detected in ARM model rat embryos; however, the expression of Wnt3a was significantly reduced compared with the normal rat embryos. Western blotting and RT­qPCR also revealed lower expression levels of Wnt3a protein and mRNA, respectively, in the SMC of ARMs model rat embryos compared with normal rat embryos. These data revealed that the expression of Wnt3a in ARM embryos was notably reduced, indicating a potential role for Wnt3a in the maldevelopment of the SMC in patients with ARMs.
[Mh] Termos MeSH primário: Malformações Anorretais/embriologia
Malformações Anorretais/genética
Embrião de Mamíferos/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Desenvolvimento Muscular/genética
Músculo Estriado/embriologia
Músculo Estriado/metabolismo
Proteína Wnt3A/genética
[Mh] Termos MeSH secundário: Animais
Western Blotting
Densitometria
Etilenotioureia
Imuno-Histoquímica
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos Wistar
Reação em Cadeia da Polimerase em Tempo Real
Fatores de Tempo
Proteína Wnt3A/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Wnt3A Protein); 24FOJ4N18S (Ethylenethiourea)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6207


  3 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28257310
[Au] Autor:Correia P; Moreira M; Rodrigues M; Inocêncio G
[Ad] Endereço:Unidade de Diagnóstico e Terapêutica Pré Natal, Centro Materno Infantil do Norte, Centro Hospitalar do Porto, Oporto, Portugal.
[Ti] Título:Prenatal Diagnosis of Vesicorectal Fistula.
[So] Source:Ultrasound Q;33(1):112-114, 2017 Mar.
[Is] ISSN:1536-0253
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anorectal malformations are a rare condition difficult to diagnose in the prenatal period. It can be suspected if distal bowel appears dilated in the first-trimester ultrasound or if intraluminal echogenic foci are detected during the second-trimester scan. We report a case with these ultrasound signs (dilated sigmoid at the first trimester and intraluminal echogenic calcifications at the second trimester), in which a vesicorectal fistula image was obtained. This is the first published prenatal image of a vesicorectal fistula.
[Mh] Termos MeSH primário: Malformações Anorretais/diagnóstico por imagem
Fístula Retal/diagnóstico por imagem
Ultrassonografia Pré-Natal/métodos
Fístula Urinária/diagnóstico por imagem
[Mh] Termos MeSH secundário: Aborto Eugênico
Adulto
Malformações Anorretais/embriologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Gravidez
Fístula Retal/embriologia
Bexiga Urinária/diagnóstico por imagem
Bexiga Urinária/embriologia
Fístula Urinária/embriologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE
[do] DOI:10.1097/RUQ.0000000000000282


  4 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28129770
[Au] Autor:Baayen C; Feuillet F; Clermidi P; Crétolle C; Sarnacki S; Podevin G; Hardouin JB
[Ad] Endereço:UMR 1246 INSERM SPHERE "methodS in Patient-centered outcomes & HEalth ResEarch", University of Nantes, Nantes, France. corine.baayen@univ-nantes.fr.
[Ti] Título:Validation of the French versions of the Hirschsprung's disease and Anorectal malformations Quality of Life (HAQL) questionnaires for adolescents and adults.
[So] Source:Health Qual Life Outcomes;15(1):24, 2017 Jan 28.
[Is] ISSN:1477-7525
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Hirschsprung's disease Anorectal malformation QoL questionnaire (HAQL) is a disease-specific quality of life (QoL) questionnaire for patients with Hirschsprung's disease (HD) or anorectal malformations (ARM). It was originally proposed in Dutch and is currently being translated into other languages to obtain an internationally standardized instrument. In this work we validate a French adaptation of the HAQL for adolescents and adults. METHODS: The questionnaires were translated into French and sent to patients aged 12 years and older, followed for HD or ARM at three French university hospitals. Questionnaires were sent to 147 adolescents and 188 adults. The psychometric properties of the questionnaires were analyzed in terms of reliability and validity. RESULTS: The original HAQL structure was not satisfactory. A new structure was proposed, while aiming to remain close to the original structure. The proposed structure has acceptable reliability and validity properties and reflects both physical, as well as psychosocial aspects. CONCLUSIONS: A French version of the HAQL questionnaire for adults and adolescents is ready for use in France. In particular the score could discriminate between degrees of clinical status based on the Krickenbeck consensus, which can aid clinicians to inform patients about physical and psychosocial challenges they may expect.
[Mh] Termos MeSH primário: Malformações Anorretais/psicologia
Doença de Hirschsprung/psicologia
Qualidade de Vida/psicologia
Inquéritos e Questionários/normas
[Mh] Termos MeSH secundário: Adaptação Psicológica
Adolescente
Adulto
Feminino
França
Seres Humanos
Masculino
Psicometria
Reprodutibilidade dos Testes
Tradução
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE
[do] DOI:10.1186/s12955-017-0599-7


  5 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28115405
[Au] Autor:Sen S; Arunachalam P; Sam CJ; Bal HS
[Ad] Endereço:Department of Paediatric Surgery, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
[Ti] Título:Residual terminal bowel fistulating into the alimentary tract: a hitherto unreported complication of surgery for anorectal malformation.
[So] Source:BMJ Case Rep;2017, 2017 Jan 23.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The residual terminal bowel after pull-through surgery for anorectal malformation has been reported to cause urinary complications. We report two boys where residual bowel has fistulated postoperatively into the alimentary tract causing metabolic and septic complication in one and a large pelvic mass with urinary and rectal obstruction in the other.
[Mh] Termos MeSH primário: Malformações Anorretais/cirurgia
Doenças do Colo/cirurgia
Fístula Intestinal/cirurgia
Obstrução Intestinal/cirurgia
Complicações Pós-Operatórias/cirurgia
Doenças Retais/cirurgia
Doenças Uretrais/cirurgia
Fístula Urinária/cirurgia
[Mh] Termos MeSH secundário: Pré-Escolar
Doenças do Colo/diagnóstico por imagem
Seres Humanos
Fístula Intestinal/complicações
Fístula Intestinal/diagnóstico por imagem
Obstrução Intestinal/diagnóstico por imagem
Obstrução Intestinal/etiologia
Masculino
Complicações Pós-Operatórias/diagnóstico por imagem
Radiografia
Doenças Retais/diagnóstico por imagem
Doenças Retais/etiologia
Sepse/etiologia
Doenças Uretrais/complicações
Doenças Uretrais/diagnóstico por imagem
Fístula Urinária/complicações
Fístula Urinária/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


  6 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28099464
[Au] Autor:Han Y; Xia Z; Guo S; Yu X; Li Z
[Ad] Endereço:Department of Pediatric Surgery, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
[Ti] Título:Laparoscopically Assisted Anorectal Pull-Through versus Posterior Sagittal Anorectoplasty for High and Intermediate Anorectal Malformations: A Systematic Review and Meta-Analysis.
[So] Source:PLoS One;12(1):e0170421, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Anorectal malformations (ARMs) are one of the commonest anomalies in neonates. Both laparoscopically assisted anorectal pull-through (LAARP) and posterior sagittal anorectoplasty (PSARP) can be used for the treatment of ARMs. The aim of this systematic review and meta-analysis is to compare these two approaches in terms of intraoperative and postoperative outcomes. METHODS: MEDLINE, Embase, Web of Science and the Cochrane Library were searched from 2000 to August 2016. Both randomized and non-randomized studies, assessing LAARP and PSARP in pediatric patients with high/intermediate ARMs, were included. The primary outcome measures were operative time, length of hospital stay and total postoperative complications. The second outcome measures were rectal prolapse, anal stenosis, wound infection/dehiscence, anorectal manometry, Kelly's clinical score, and Krickenbeck classification. The quality of the randomized and non-randomized studies was assessed using the Cochrane Collaboration's Risk of Bias tool and Newcastle-Ottawa scale (NOS) respectively. The quality of evidence was assessed by GRADEpro. RESULTS: From 332 retrieved articles, 1, 1, and 8 of randomized control, prospective and retrospective studies, respectively, met the inclusion criteria. The randomized clinical trial was judged to be of low risk of bias, and the nine cohort studies were of moderate to high quality. 191 and 169 pediatric participants had undergone LAARP and PSARP, respectively. Shorter hospital stays, less wound infection/dehiscence, higher anal canal resting pressure, and a lower incidence of grade 2 or 3 constipation were obtained after LAARP compared with PSARP group values. Besides, the LAARP group had marginally less total postoperative complications. However, the result of operative time was inconclusive; meanwhile, there was no significant difference in rectal prolapse, anal stenosis, anorectal manometry, Kelly's clinical score and Krickenbeck classification. CONCLUSION: For pediatric patients with high/intermediate anorectal malformations, LAARP is a better option compared with PSARP. However, the quality of evidence was very low to moderate.
[Mh] Termos MeSH primário: Canal Anal/cirurgia
Malformações Anorretais/cirurgia
Laparoscopia/métodos
Reto/cirurgia
[Mh] Termos MeSH secundário: Canal Anal/anormalidades
Seres Humanos
Recém-Nascido
Tempo de Internação/estatística & dados numéricos
Complicações Pós-Operatórias
Reto/anormalidades
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170421


  7 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28070723
[Au] Autor:Lopez MP; Encila VI; Alamo SG; Monroy HJ; Roxas MF
[Ad] Endereço:Division of Colorectal Surgery, Philippine General HospitalUniversity of the Philippines, Taft Avenue, 1000, Manila, Philippines.
[Ti] Título:Anorectal malformations: definitive surgery during adulthood.
[So] Source:Tech Coloproctol;21(2):111-118, 2017 02.
[Is] ISSN:1128-045X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Anorectal malformations (ARMs) are rarely seen in adults, since majority of cases are corrected in infancy or childhood. The aim of this study was to describe the profile of patients who underwent definitive surgery to correct their ARM in adulthood, and to discuss the outcomes of surgery (morbidity, mortality, and function). METHODS: This retrospective study included patients 18 years old and above, managed surgically by the Division of Colorectal Surgery at the Philippine General Hospital, University of the Philippines, Manila, from January 1, 2004, to December 31, 2012. Data from the Integrated Surgical Information System and the patients' hospital records were used to fill out a Data Collection Form. Frequencies and percentages were then computed. RESULTS: Eight patients were included in the study. The most common reason for consult was recurrent urinary tract infection (UTI, 25%). One patient had an imperforate anus (IA) without a fistula, and 1 patient had IA with rectal atresia, and the 6 had an IA with a fistula. All but one (87.5%) of the patients had undergone a prior diversion in infancy or childhood. Definitive surgical procedures included posterior sagittal anorectoplasty (PSARP) in 3 patients, anal transposition in 2 patients, laparotomy with colocutaneous anastomosis in two patients, and laparotomy and PSARP in 1 patient. There were 3 cases (37.5%) of postoperative complications. These complications included ureteral injury, enterocutaneous fistula, anal stricture, rectal stricture, rectovesical fistula, and recurrent rectourethral fistula. There was no reported mortality. Five patients already had their stomas reversed at the time of this writing. CONCLUSION: Our results showed that the rarity of the disease, limited surgical experience, and a technically challenging anatomy make the management of ARMs that persist into adulthood a formidable undertaking.
[Mh] Termos MeSH primário: Fatores Etários
Malformações Anorretais/cirurgia
Procedimentos Cirúrgicos do Sistema Digestório/métodos
Procedimentos Cirúrgicos Reconstrutivos/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Canal Anal/patologia
Canal Anal/cirurgia
Anus Imperfurado/cirurgia
Feminino
Seres Humanos
Masculino
Filipinas
Complicações Pós-Operatórias/etiologia
Fístula Retal/congênito
Fístula Retal/cirurgia
Reto/patologia
Reto/cirurgia
Estudos Retrospectivos
Resultado do Tratamento
Doenças Uretrais/etiologia
Doenças Uretrais/cirurgia
Fístula Urinária/etiologia
Fístula Urinária/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1007/s10151-016-1577-5


  8 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27894765
[Au] Autor:Danielson J; Karlbom U; Graf W; Wester T
[Ad] Endereço:Institution of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Department of Pediatric Surgery, Akademiska Sjukhuset Uppsala, Sweden. Electronic address: johan.danielsson@akademiska.se.
[Ti] Título:Outcome in adults with anorectal malformations in relation to modern classification - Which patients do we need to follow beyond childhood?
[So] Source:J Pediatr Surg;52(3):463-468, 2017 Mar.
[Is] ISSN:1531-5037
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/PURPOSE: Knowledge about the functional outcome in adults with anorectal malformations is essential to organize structured transition to adult care for this patient group. The aim of this study was to investigate the functional outcome and quality of life in adults with anorectal malformations characterized according to the Krickenbeck classification. METHODS: Of 256 patients diagnosed with anorectal malformations at our institution in 1961-1993, 203 patients could be traced and were invited to participate in the study. One hundred and thirty-six patients replied (67%) and were compared with one hundred and thirty-six population based sex and age-matched controls. Patients and controls were evaluated with both a validated questionnaire as well as a study-specific questionnaire to assess bowel function. SF-36 was used for quality of life. Outcome in nine incontinence-related parameters, 10 constipation-related, 6 urogenital function-related, and 13 quality of life parameters were assessed in the patients and compared to the outcome of controls as well as to the type of anorectal malformations according to the Krickenbeck classification. RESULTS: The ARM-patients had an inferior outcome (P<0.05) for all incontinence parameters, 8 of 10 parameters for constipation, 2 of 6 for urogenital function and 7 of 13 quality of life parameters. Patients with rectobulbar and vestibular fistulas had the worst statistical outcome but patients with cloaca and rectoprostatic/bladder-neck fistula had worse outcome in absolute numbers. Forty-four patients (32%) reported incontinence of stool at least once a week and 16 (12%) had a permanent colostomy. CONCLUSIONS: The functional outcome and quality of life in adults with anorectal malformations are closely related to the type of malformation. A large proportion of the patients have persistent fecal incontinence, constipation and sexual problems that have a negative influence on their quality of life. Structured multidisciplinary follow-up of adults with anorectal malformations by pediatric and colorectal surgeons, as well as urologists and gynecologists is therefore advocated.
[Mh] Termos MeSH primário: Canal Anal/anormalidades
Malformações Anorretais/classificação
Qualidade de Vida
Reto/anormalidades
[Mh] Termos MeSH secundário: Anormalidades Múltiplas
Adulto
Canal Anal/fisiopatologia
Canal Anal/cirurgia
Malformações Anorretais/complicações
Malformações Anorretais/cirurgia
Estudos de Casos e Controles
Constipação Intestinal/etiologia
Constipação Intestinal/fisiopatologia
Incontinência Fecal/etiologia
Incontinência Fecal/fisiopatologia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Reto/fisiopatologia
Reto/cirurgia
Disfunções Sexuais Fisiológicas/etiologia
Disfunções Sexuais Fisiológicas/fisiopatologia
Inquéritos e Questionários
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


  9 / 347 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27836356
[Au] Autor:Santos-Jasso KA; Arredondo-García JL; Maza-Vallejos J; Lezama-Del Valle P
[Ad] Endereço:Department of General Pediatric Surgery, Instituto Nacional de Pediatría, Ciudad de México, Mexico 04530. Electronic address: santosjasso@hotmail.com.
[Ti] Título:Effectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation.
[So] Source:J Pediatr Surg;52(1):84-88, 2017 Jan.
[Is] ISSN:1531-5037
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Constipation is present in 80% of children with corrected anorectal malformations, usually associated to rectal dilation and hypomotility. Osmotic laxatives are routinely used for idiopathic constipation. Senna is a stimulant laxative that produces contractions improving colonic motility without affecting the stool consistency. We designed this trial to study the effectiveness of Senna versus polyethylene glycol for the treatment of constipation in children with anorectal malformation. METHODS: A randomized controlled crossover design clinical trial, including a washout period, was conducted, including children with corrected anorectal malformations with fecal continence and constipation. The sample size was calculated for proportions (n=28) according to available data for Senna. Effectiveness of laxative therapy was measured with a three variable construct: 1) daily bowel movement, 2) fecal soiling, 3) a "clean" abdominal x-ray. Data analysis included descriptive statistics and a Fisher's exact test for the outcome variable (effectiveness). RESULTS: The study was terminated early because the interim analysis showed a clear benefit toward Senna (p = 0.026). The sample showed a normal statistical distribution for the variables age and presence of megarectum. The maximum daily dose of Senna (sennosides A and B) was 38.7mg and 17g for polyethylene glycol. No adverse effects were identified. CONCLUSION: Therapy with Senna should be the laxative treatment of choice as part of a bowel management program in children with repaired anorectal malformations and constipation, since the stimulation of colonic propulsion waves could lead to stool evacuation without modification of its consistency which can affect fecal continence. LEVEL OF EVIDENCE: I - randomized controlled trial with adequate statistical power.
[Mh] Termos MeSH primário: Malformações Anorretais/complicações
Catárticos/uso terapêutico
Constipação Intestinal/tratamento farmacológico
Laxantes/uso terapêutico
Polietilenoglicóis/uso terapêutico
Extrato de Sena/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Constipação Intestinal/etiologia
Estudos Cross-Over
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cathartics); 0 (Laxatives); 30IQX730WE (Polyethylene Glycols); 8013-11-4 (Senna Extract); 9VK7V8762D (sennoside A&B)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


  10 / 347 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27695999
[Au] Autor:Sharma S; Gupta DK
[Ad] Endereço:Department of Pediatric Surgery, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, 110029, India. drshilpas@gmail.com.
[Ti] Título:Diversities of H-type anorectal malformation: a systematic review on a rare variant of the Krickenbeck classification.
[So] Source:Pediatr Surg Int;33(1):3-13, 2017 Jan.
[Is] ISSN:1437-9813
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Congenital H-type fistula is a rare congenital rectourogenital connection with an external anal opening in a normal or ectopic position. A systematic review was done to study the anatomical types of congenital H-type fistula, embryology, clinical presentation, relative gender distribution, associated anomalies, investigative modalities, and recent advances in treatment of these lesions. A PubMed search included H-type anorectal malformation; H-type anorectal malformations; H-type anorectal; and H-type congenital anorectal that gave 9;43;76;26 abstracts, respectively. Relevant studies and cited articles were studied omitting duplicate search. The reported incidence is 0.1-16 % of all anorectal malformation. The H-type anorectal malformation is 2.5-6 times more common in females and usually associated with a normal anus. In males, the anomaly is usually a variant with an ectopic anus or a perineal fistula. Anatomical types include anovestibular; rectovestibular; rectovaginal fistula in females and rectourethral (bulbar, prostatic, bladder neck) and rectovesical fistula in males. Variants identified include H-type fistula with perineal fistula, perineal groove, H-type sinus, H-type canal, and acquired H-type fistula. This review compiles the available literature over last six decades. Various surgical corrective procedures have been described. The high recurrence decreases with a learning curve and experience.
[Mh] Termos MeSH primário: Canal Anal/anormalidades
Malformações Anorretais/classificação
Reto/anormalidades
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1007/s00383-016-3982-2



página 1 de 35 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde