Base de dados : MEDLINE
Pesquisa : C06.405 [Categoria DeCS]
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[PMID]:29377961
[Au] Autor:DeBerg HA; Zaidi MB; Altman MC; Khaenam P; Gersuk VH; Campos FD; Perez-Martinez I; Meza-Segura M; Chaussabel D; Banchereau J; Estrada-Garcia T; Linsley PS
[Ad] Endereço:Benaroya Research Institute at Virginia Mason, Seattle, Washington, United States of America.
[Ti] Título:Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling.
[So] Source:PLoS One;13(1):e0192082, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time and cost considerations associated with pathogen-specific screening and hence pathogen-directed therapy is uncommon. The development of biomarkers to rapidly identify underlying pathogens could improve treatment options and clinical outcomes in childhood diarrheal diseases. Here, we perform RNA sequencing on blood samples collected from children evaluated in an emergency room setting with diarrheal disease where the pathogen(s) present are known. We determine host response gene signatures specific to Salmonella, Shigella and rotavirus, but not E. coli, infections that distinguish them from each other and from healthy controls. Specifically, we observed differential expression of genes related to chemokine receptors or inflammasome signaling in Shigella cases, such as CCR3, CXCR8, and NLRC4, and interferon response genes, such as IFI44 and OASL, in rotavirus cases. Our findings add insight into the host peripheral immune response to these pathogens, and suggest strategies and limitations for the use host response transcript signatures for diagnosing the etiologic agent of childhood diarrheal diseases.
[Mh] Termos MeSH primário: Diarreia/imunologia
Perfilação da Expressão Gênica
RNA Mensageiro/sangue
[Mh] Termos MeSH secundário: Criança
Diarreia/sangue
Diarreia/genética
Gastroenteropatias/genética
Gastroenteropatias/microbiologia
Seres Humanos
Rotavirus/isolamento & purificação
Shigella/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Messenger)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0192082


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[PMID]:27773806
[Au] Autor:Wooden B; Goossens N; Hoshida Y; Friedman SL
[Ad] Endereço:Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
[Ti] Título:Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases.
[So] Source:Gastroenterology;152(1):53-67.e3, 2017 Jan.
[Is] ISSN:1528-0012
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Technologies such as genome sequencing, gene expression profiling, proteomic and metabolomic analyses, electronic medical records, and patient-reported health information have produced large amounts of data from various populations, cell types, and disorders (big data). However, these data must be integrated and analyzed if they are to produce models or concepts about physiological function or mechanisms of pathogenesis. Many of these data are available to the public, allowing researchers anywhere to search for markers of specific biological processes or therapeutic targets for specific diseases or patient types. We review recent advances in the fields of computational and systems biology and highlight opportunities for researchers to use big data sets in the fields of gastroenterology and hepatology to complement traditional means of diagnostic and therapeutic discovery.
[Mh] Termos MeSH primário: Biologia Computacional
Descoberta de Drogas/métodos
Gastroenteropatias/diagnóstico
Gastroenteropatias/tratamento farmacológico
Hepatopatias/diagnóstico
Hepatopatias/tratamento farmacológico
[Mh] Termos MeSH secundário: Biomarcadores
Mineração de Dados
Seres Humanos
Terapia de Alvo Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29406641
[Au] Autor:Celia T; Freysteinson WW; Frye RE
[Ti] Título:Concurrent Medical Conditions in Autism Spectrum Disorders.
[So] Source:Pediatr Nurs;42(5):230-4, 2016 Sep-Oct.
[Is] ISSN:0097-9805
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Long thought to be purely psychological in origin, current research lends credenceto the idea that autism has a medical basis. Patients with autism can be among themost challenging patients that a healthcare provider may care for. Often the presentingsymptoms of autism make these patients difficult to examine and may alsomask underlying concurrent conditions. This article reviews some of the more commonconditions found concurrently in the autistic population.
[Mh] Termos MeSH primário: Transtorno do Espectro Autista/complicações
Transtorno do Espectro Autista/diagnóstico
Gastroenteropatias/etiologia
Doenças do Sistema Imune/etnologia
Doenças do Sistema Nervoso/etiologia
Transtornos do Sono-Vigília/etiologia
[Mh] Termos MeSH secundário: Adolescente
Transtorno do Espectro Autista/epidemiologia
Transtorno do Espectro Autista/fisiopatologia
Criança
Pré-Escolar
Comorbidade
Feminino
Gastroenteropatias/epidemiologia
Gastroenteropatias/terapia
Seres Humanos
Doenças do Sistema Imune/epidemiologia
Doenças do Sistema Imune/terapia
Lactente
Masculino
Doenças do Sistema Nervoso/epidemiologia
Doenças do Sistema Nervoso/terapia
Transtornos do Sono-Vigília/epidemiologia
Transtornos do Sono-Vigília/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28463151
[Au] Autor:O'Callaghan ME; Raymond E; Campbell JM; Vincent AD; Beckmann K; Roder D; Evans S; McNeil J; Millar J; Zalcberg J; Borg M; Moretti K
[Ad] Endereço:South Australian Prostate Cancer Clinical Outcomes Collaborative; Freemasons Foundation Centre for Men's Health, University of Adelaide; Urology Unit, Repatriation General Hospital, SA Health; Flinders Centre for Innovation in Cancer. Electronic address: elspeth.raymond@health.sa.gov.au.
[Ti] Título:Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):318-337, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To identify, through a systematic review, all validated tools used for the prediction of patient-reported outcome measures (PROMs) in patients being treated with radiation therapy for prostate cancer, and provide a comparative summary of accuracy and generalizability. METHODS AND MATERIALS: PubMed and EMBASE were searched from July 2007. Title/abstract screening, full text review, and critical appraisal were undertaken by 2 reviewers, whereas data extraction was performed by a single reviewer. Eligible articles had to provide a summary measure of accuracy and undertake internal or external validation. Tools were recommended for clinical implementation if they had been externally validated and found to have accuracy ≥70%. RESULTS: The search strategy identified 3839 potential studies, of which 236 progressed to full text review and 22 were included. From these studies, 50 tools predicted gastrointestinal/rectal symptoms, 29 tools predicted genitourinary symptoms, 4 tools predicted erectile dysfunction, and no tools predicted quality of life. For patients treated with external beam radiation therapy, 3 tools could be recommended for the prediction of rectal toxicity, gastrointestinal toxicity, and erectile dysfunction. For patients treated with brachytherapy, 2 tools could be recommended for the prediction of urinary retention and erectile dysfunction. CONCLUSIONS: A large number of tools for the prediction of PROMs in prostate cancer patients treated with radiation therapy have been developed. Only a small minority are accurate and have been shown to be generalizable through external validation. This review provides an accessible catalogue of tools that are ready for clinical implementation as well as which should be prioritized for validation.
[Mh] Termos MeSH primário: Disfunção Erétil/etiologia
Gastroenteropatias/etiologia
Medidas de Resultados Relatados pelo Paciente
Neoplasias da Próstata/radioterapia
Retenção Urinária/etiologia
[Mh] Termos MeSH secundário: Idoso
Braquiterapia/efeitos adversos
Coleta de Dados/métodos
Seres Humanos
Masculino
Prognóstico
Estudos Prospectivos
Neoplasias da Próstata/patologia
Qualidade de Vida
Reprodutibilidade dos Testes
Estudos Retrospectivos
Transtornos Urinários/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29360884
[Au] Autor:Adams NL; Rose TC; Hawker J; Violato M; O'Brien SJ; Barr B; Howard VJK; Whitehead M; Harris R; Taylor-Robinson DC
[Ad] Endereço:NIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
[Ti] Título:Relationship between socioeconomic status and gastrointestinal infections in developed countries: A systematic review and meta-analysis.
[So] Source:PLoS One;13(1):e0191633, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The association between socioeconomic status (SES) and health is well-documented; however limited evidence on the relationship between SES and gastrointestinal (GI) infections exists, with published studies producing conflicting results. This systematic review aimed to assess the association between SES and GI infection risk, and explore possible sources of heterogeneity in effect estimates reported in the literature. METHODS: MEDLINE, Scopus, Web of Science and grey literature were searched from 1980 to October 2015 for studies reporting an association between GI infections and SES in a representative population sample from a member-country of the Organisation for Economic Co-operation and Development. Harvest plots and meta-regression were used to investigate potential sources of heterogeneity such as age; level of SES variable; GI infection measurement; and predominant mode of transmission. The protocol was registered on PROSPERO: CRD42015027231. RESULTS: In total, 6021 studies were identified; 102 met the inclusion criteria. Age was identified as the only statistically significant potential effect modifier of the association between SES and GI infection risk. For children, GI infection risk was higher for those of lower SES versus high (RR 1.51, 95% CI;1.26-1.83), but there was no association for adults (RR 0.79, 95% CI;0.58-1.06). In univariate analysis, the increased risk comparing low and high SES groups was significantly higher for pathogens spread by person-to-person transmission, but lower for environmental pathogens, as compared to foodborne pathogens. CONCLUSIONS: Disadvantaged children, but not adults, have greater risk of GI infection compared to their more advantaged counterparts. There was high heterogeneity and many studies were of low quality. More high quality studies are needed to investigate the association between SES and GI infection risk, and future research should stratify analyses by age and pathogen type. Gaining further insight into this relationship will help inform policies to reduce inequalities in GI illness in children.
[Mh] Termos MeSH primário: Gastroenteropatias/epidemiologia
Infecção/epidemiologia
Classe Social
[Mh] Termos MeSH secundário: Países Desenvolvidos
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191633


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[PMID]:29419664
[Au] Autor:Lin H; Wang X; Du X; Wang J; Li Y; Zhang R
[Ad] Endereço:The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou.
[Ti] Título:Effect of Zhizhu Kuanzhong capsule on functional dyspepsia: Protocol for a systematic review and meta-analysis of randomized controlled trials.
[So] Source:Medicine (Baltimore);97(6):e9731, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Functional dyspepsia (FD) is a gastrointestinal disorder affecting people in the globe. Spleen-deficiency syndrome is one of its basic syndromes. Zhizhu Kuanzhong capsule was the most frequent Chinese herbal formula used in the spleen-deficiency researches. We aim to assess the effectiveness and safety of Zhizhu Kuanzhong capsule on FD. METHODS: A systematic literature search for randomized controlled trials (RCTs) from their inception until December 31, 2017 will be conducted using 7 databases: PubMed, Cochrane Library, Embase, VIP Database, Chinese National Knowledge Infrastructure, Wanfang Data, and Chinese BioMedical Database. Inclusion the trials of Zhizhu Kuanzhong capsule which evaluate motilin level, clinical syndrome, and side effect in people with FD. The primary outcome measures will be motilin level, clinical syndrome integral, and clinical total effective rate. Data extraction and risk of bias assessments will be performed by 2 reviewers independently. Methodological and reporting quality of included studies will be assessed by the consolidated standards of reporting trials for Chinese herbal medicine formulas. All statistical analyses will be conducted using RevMan V.5.3 software. Funnel plots, Begg's test, and Egger's test will be developed to evaluate reporting bias. RESULTS: This review will assess the effect of Zhizhu Kuanzhong capsule on clinical total effective rate, symptom remission rate, plasma motilin level, and safety of FD in patients. CONCLUSION: The conclusion of our study will provide updated evidence to judge whether Zhizhu Kuanzhong capsule is an effective intervention for patients with FD.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
Dispepsia/tratamento farmacológico
Gastroenteropatias/tratamento farmacológico
Metanálise como Assunto
Fitoterapia
Esplenopatias
[Mh] Termos MeSH secundário: Gastroenteropatias/complicações
Gastroenteropatias/diagnóstico
Gastroenteropatias/fisiopatologia
Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Projetos de Pesquisa
Esplenopatias/tratamento farmacológico
Esplenopatias/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180209
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009731


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[PMID]:29328612
[Au] Autor:Roganovic B; Peric S; Jankovic SR
[Ti] Título:The impact of in-hospital nutritional status deterioration on treatment outcome of adult gastroenterological patients.
[So] Source:Vojnosanit Pregl;73(8):764-9, 2016 Aug.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: In the current literature, data on impact of intrahospital changes in patients' nutritional status on the treatment outcome are limited. The aim of this study was to investigate the relationship between nutritional status deterioration and the treatment outcome among hospitalized gastroenterological patients. Methods: In 650 adult gastroenterological patients nutritional status on admission and at discharge was evaluated using the 6 nutritional status assessment parameters: body mass index, triceps skinfold thickness, mid-upper arm muscle circumference, serum albumin concentration, lymphocyte count and unintentional weight loss. The influence on treatment outcome was tested for the nutritional status on admission, nutritional status at discharge and intrahospital nutritional status deterioration. Results: The incidence of favorable outcome in the non-undernourished and undernourished patients on admission was in the range 93.4-97.3% and 81.2- 91.2%, respectively. The incidence of favorable outcome in the non-undernourished and undernourished patients at discharge was in the range 94-97.4% and 80.8-88.1%, respectively. Favorable outcomes were obtained in 95.6-98.9% of the patients without nutritional status deterioration and in 87.1-90.3% of the patients with nutritional status deterioration. Intrahospital nutritional status deterioration significantly influenced the outcome, no matter what assessment parameter had been used (p < 0.001 for all the applied parameters). Furthermore, only the deterioration of nutritional status was found to be an independent predictor of treatment outcome (multivariate analysis Forwald Wald, p £ 0.001; relative risk (RR) = 0.104-0.350; confidence intervals (CI) = 0.037-0.186/0.297-0.657). Conclusion: Deterioration of nutritional status is an independent predictor of adverse outcome.
[Mh] Termos MeSH primário: Gastroenteropatias/fisiopatologia
Gastroenteropatias/terapia
Hospitalização
Estado Nutricional
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Avaliação Nutricional
Sérvia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150518104R


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[PMID]:29201297
[Au] Autor:Lee M; Yoo J; Kim JG; Kyung HS; Bin SI; Kang SB; Choi CH; Moon YW; Kim YM; Han SB; In Y; Choi CH; Kim J; Lee BK; Cho S
[Ad] Endereço:Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, Korea.
[Ti] Título:A Randomized, Multicenter, Phase III Trial to Evaluate the Efficacy and Safety of Polmacoxib Compared with Celecoxib and Placebo for Patients with Osteoarthritis.
[So] Source:Clin Orthop Surg;9(4):439-457, 2017 Dec.
[Is] ISSN:2005-4408
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Background: The aim of this study was to evaluate the safety and analgesic efficacy of polmacoxib 2 mg versus placebo in a superiority comparison or versus celecoxib 200 mg in a noninferiority comparison in patients with osteoarthritis (OA). Methods: This study was a 6-week, phase III, randomized, double-blind, and parallel-group trial followed by an 18-week, single arm, open-label extension. Of the 441 patients with knee or hip OA screened, 362 were randomized; 324 completed 6 weeks of treatment and 220 completed the extension. Patients were randomized to receive oral polmacoxib 2 mg (n = 146), celecoxib 200 mg (n = 145), or placebo (n = 71) once daily for 6 weeks. During the extension, all participants received open-label polmacoxib 2 mg. The primary endpoint was the change in Western Ontario and McMaster Universities (WOMAC)-pain subscale score from baseline to week 6. Secondary endpoints included WOMAC-OA Index, OA subscales (pain, stiffness, and physical function) and Physician's and Subject's Global Assessments at weeks 3 and 6. Other outcome measures included adverse events (AEs), laboratory tests, vital signs, electrocardiograms, and physical examinations. Results: After 6 weeks, the polmacoxib-placebo treatment difference was -2.5 (95% confidence interval [CI], -4.4 to -0.6; = 0.011) and the polmacoxib-celecoxib treatment difference was 0.6 (CI, -0.9 to 2.2; = 0.425). According to Physician's Global Assessments, more subjects were "much improved" at week 3 with polmacoxib than with celecoxib or placebo. Gastrointestinal and general disorder AEs occurred with a greater frequency with polmacoxib or celecoxib than with placebo. Conclusions: Polmacoxib 2 mg was relatively well tolerated and demonstrated efficacy superior to placebo and noninferior to celecoxib after 6 weeks of treatment in patients with OA. The results obtained during the 18-week trial extension with polmacoxib 2 mg were consistent with those observed during the 6-week treatment period, indicating that polmacoxib can be considered safe for long-term use based on this relatively small scale of study in a Korean population. More importantly, the results of this study showed that polmacoxib has the potential to be used as a pain relief drug with reduced gastrointestinal side effects compared to traditional nonsteroidal anti-inflammatory drugs for OA.
[Mh] Termos MeSH primário: Celecoxib/uso terapêutico
Inibidores de Ciclo-Oxigenase 2/uso terapêutico
Furanos/uso terapêutico
Dor Musculoesquelética/tratamento farmacológico
Osteoartrite do Quadril/tratamento farmacológico
Osteoartrite do Joelho/tratamento farmacológico
Sulfonamidas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Celecoxib/efeitos adversos
Inibidores de Ciclo-Oxigenase 2/efeitos adversos
Método Duplo-Cego
Feminino
Furanos/efeitos adversos
Gastroenteropatias/induzido quimicamente
Seres Humanos
Masculino
Meia-Idade
Dor Musculoesquelética/etiologia
Osteoartrite do Quadril/complicações
Osteoartrite do Quadril/fisiopatologia
Osteoartrite do Joelho/complicações
Osteoartrite do Joelho/fisiopatologia
Amplitude de Movimento Articular
Sulfonamidas/efeitos adversos
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE III; COMPARATIVE STUDY; EQUIVALENCE TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (CG100649); 0 (Cyclooxygenase 2 Inhibitors); 0 (Furans); 0 (Sulfonamides); JCX84Q7J1L (Celecoxib)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.4055/cios.2017.9.4.439


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[PMID]:29187322
[Au] Autor:Jagai JS; DeFlorio-Barker S; Lin CJ; Hilborn ED; Wade TJ
[Ad] Endereço:Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA.
[Ti] Título:Sanitary Sewer Overflows and Emergency Room Visits for Gastrointestinal Illness: Analysis of Massachusetts Data, 2006-2007.
[So] Source:Environ Health Perspect;125(11):117007, 2017 11 28.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sanitary sewer overflows (SSOs) occur when untreated sewage is discharged into water sources before reaching the treatment facility, potentially contaminating the water source with gastrointestinal pathogens. OBJECTIVES: The objective of this paper is to assess associations between SSO events and rates of gastrointestinal (GI) illness in Massachusetts. METHODS: A case-crossover study design was used to investigate association between SSO events and emergency room (ER) visits with a primary diagnosis of gastrointestinal (GI) illness in Massachusetts for 2006-2007. ER visits for GI were considered exposed if an SSO event occurred in the county of residence within three hazard periods, 0-4 d, 5-9 d, or 10-14 d, before the visit. A time-stratified bidirectional design was used to select control days for each ER visit on the same day of the week during the same month. Fixed effect logistic regression models were used to estimate the risk of ER visits following the SSO event. RESULTS: During the study period, there were 270 SSO events for northeastern Massachusetts and 66,460 ER admissions with GI illness listed as the primary diagnostic code. The overall odds ratio (OR) for ER visits for GI illness was 1.09 [95% confidence interval (CI): 1.03, 1.16] in the 10-14 d period following an SSO event, with positive ORs for all age groups and for three of the four counties. The 0-4 d and 5-9 d periods following an SSO event were not associated with ER visits for GI illness overall, and associations by county or age were inconsistent. CONCLUSIONS: We demonstrated an association between SSO events and ER visits for GI illness using a case-crossover study design. In light of the aging water infrastructure in the United States and the expected increase in heavy rainfall events, our findings suggest a potential health impact associated with sewage overflows. https://doi.org/10.1289/EHP2048.
[Mh] Termos MeSH primário: Drenagem Sanitária/estatística & dados numéricos
Gastroenteropatias/epidemiologia
Hospitalização/estatística & dados numéricos
[Mh] Termos MeSH secundário: Serviço Hospitalar de Emergência
Seres Humanos
Modelos Logísticos
Massachusetts/epidemiologia
Esgotos
Eliminação de Resíduos Líquidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Sewage)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1289/EHP2048


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[PMID]:28471407
[Au] Autor:Rodríguez-Tapia L; Morales-Novelo JA
[Ad] Endereço:Economic's Department, Metropolitan Autonomous University, Av. San Pablo No. 180, Colonia Reynosa Tamaulipas, C.P. 02200, CDMX, Mexico. lrt@correo.azc.uam.mx.
[Ti] Título:Bacterial Pollution in River Waters and Gastrointestinal Diseases.
[So] Source:Int J Environ Res Public Health;14(5), 2017 05 04.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Currently, one of Mexico's most severe environmental problems is the high levels of pollution of many of its rivers. The present article focuses on the relationship between total coliform bacteria levels and the increase of human digestive tract diseases in the highly polluted Atoyac River in the central Mexican states of Puebla and Tlaxcala. Pollution has become a potential health hazard for people living in nearby river communities. Based on data collected from six of the most contaminated riverside municipalities, two environmental models were developed taking into consideration the health of the entire population, not simply that of its individual members. Such models estimate a health-disease function that confirm the link between Atoyac River pollution and the incidence of gastrointestinal diseases. The causal relation between pollution and gastrointestinal disease incentivizes the creation of epidemiological and public health programs aimed at reducing the environmental health impact of the pollution associated with the Atoyac River. The results presented here are the first of their kind of this river and will serve as basis for future research exploring other similarly contaminated riparian communities. As the causes of pollution are directly related to the economic development and population growth of the region, further research should be conducted for prevention of diseases, educational programs, water remediation and conservation programs that will have a positive impact on the quality of life of the population presently at risk.
[Mh] Termos MeSH primário: Enterobacteriaceae/isolamento & purificação
Saúde Ambiental
Gastroenteropatias/epidemiologia
Rios/microbiologia
[Mh] Termos MeSH secundário: Gastroenteropatias/microbiologia
Incidência
México/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE



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