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[PMID]:29226662
[Au] Autor:Ihara E; Muta K; Fukaura K; Tanaka Y; Bai X; Aso A; Iwasa T; Nakamura K
[Ti] Título:New Approach to Diagnosis and Treatment of Esophageal Motility Disorders by High-Resolution manometry.
[So] Source:Fukuoka Igaku Zasshi;107(7):121-30, 2016 07.
[Is] ISSN:0016-254X
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Esophageal motility disorders (EMD) is characterized by impaired coordinated esophageal motility function with symptoms including dysphasia, heartburn or noncardiac chest pain. Since EMDs is functional disorders, it is usually difficult to make a diagnosis by conventional examinations including endoscopy and esophagography. Recently developed high-resolution manometry allows us to evaluate esophageal motility function precisely and to make a differential diagnosis of EMDs, together with Chicago Classification (CC) version 3.0 (CC ver3.0). In this article, we reviewed diagnosis of EMDs based on CC ver3.0 and current treatment strategy for EMDs.
[Mh] Termos MeSH primário: Transtornos da Motilidade Esofágica/fisiopatologia
Manometria
[Mh] Termos MeSH secundário: Transtornos da Motilidade Esofágica/diagnóstico
Transtornos da Motilidade Esofágica/terapia
Junção Esofagogástrica/fisiopatologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; ENGLISH ABSTRACT
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:28746079
[Au] Autor:George NS; Rangan V; Geng Z; Khan F; Kichler A; Gabbard S; Ganocy S; Fass R
[Ad] Endereço:*The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center †The Esophageal Center, The Cleveland Clinic Foundation, Cleveland, OH.
[Ti] Título:Distribution of Esophageal Motor Disorders in Diabetic Patients With Dysphagia.
[So] Source:J Clin Gastroenterol;51(10):890-895, 2017 Nov/Dec.
[Is] ISSN:1539-2031
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus can cause various gastrointestinal symptoms. Assessment of esophageal dysmotility in diabetic patients has been scarcely studied. The aim of this study was to determine the esophageal motor characteristics of diabetic versus nondiabetic patients who present with dysphagia. METHODS: High-resolution esophageal manometries (HREMs) of 83 diabetic patients and 83 age and gender-matched nondiabetic patients with dysphagia from 2 medical centers were included in this study. Demographic information, medical comorbidities, and medication usage were recorded for each patient in a single registry. HREM of each patient was evaluated and the different functional parameters were recorded. KEY RESULTS: Overall, 46% of diabetic patients were found to have an esophageal motor disorder. Diabetic patients with dysphagia were more likely to have failed swallows on HREM (50.6% vs. 33.7%; P=0.03) as compared with nondiabetic patients. Among diabetic patients, those being treated with insulin were more likely to have failed (69.0% vs. 40.7%; P=0.01) and weak (65.5% vs. 33.3%; P=0.005) swallows as compared with diabetic patients not on insulin. Among diabetic patients, those with abnormal manometry were more likely to demonstrate diabetic retinopathy (27.0% vs. 8.7%; P=0.04). There was a trend toward increased incidence of esophagogastric junction outflow obstruction in diabetic patients (10.8% vs. 2.4%; P=0.057) as compared with nondiabetic patients. CONCLUSIONS: Nearly half of diabetic patients with dysphagia have some type of an esophageal motility disorder. Diabetic retinopathy and the use of insulin are predictive of esophageal motor abnormalities among diabetic patients.
[Mh] Termos MeSH primário: Transtornos de Deglutição/epidemiologia
Complicações do Diabetes/epidemiologia
Transtornos da Motilidade Esofágica/epidemiologia
Manometria/métodos
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Transtornos de Deglutição/etiologia
Diabetes Mellitus/tratamento farmacológico
Diabetes Mellitus/fisiopatologia
Retinopatia Diabética/epidemiologia
Junção Esofagogástrica/fisiopatologia
Feminino
Seres Humanos
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/efeitos adversos
Incidência
Insulina/administração & dosagem
Insulina/efeitos adversos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Insulin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1097/MCG.0000000000000894


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[PMID]:28449422
[Au] Autor:Jeong J; Kim SE; Park MI; Park SJ; Moon W; Kim JH; Jung K; Choi YJ; Lee JY; Lee YD
[Ad] Endereço:Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
[Ti] Título:The Effect of Anti-reflux Therapy on Patients Diagnosed with Minor Disorders of Peristalsis in High-resolution Manometry.
[So] Source:Korean J Gastroenterol;69(4):212-219, 2017 Apr 25.
[Is] ISSN:2233-6869
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Background/Aims: Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders. Methods: Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy. Thereafter, the response to treatment was assessed after at least 4 weeks of treatment. Results: A total of 24 patients were identified as having minor disorders of peristalsis from January 2010 to December 2015. The mean follow-up period was 497 days, and there were 17 patients (70.8%) patients with ineffective esophageal motility. In terms of anti-reflux therapy, proton pump inhibitors (PPIs) with prokinetic agents and PPIs alone were prescribed in 19 patients (79.2%) and 5 patients (20.8%), respectively. When the rate of response to the treatment was assessed, the responders rate (complete+satisfactory [≥50%] responses) was 54.2% and the non-responders rate (partial [<50%]+refractory responses) was 45.8%. Patients in the responder group were younger than those in the non-responder group (p=0.020). Among them, 13 patients underwent 24-hour multichannel intraluminal impedance-pH, and 10 patients (76.9%) were pathologic gastroesophageal reflux. Conclusions: The majority of esophageal minor peristaltic disorders were accompanied by gastroesophageal reflux, and therefore, they might respond to acid inhibitor. Further well-designed, prospective studies are necessary to confirm the effect of anti-reflux therapy in these patients.
[Mh] Termos MeSH primário: Transtornos da Motilidade Esofágica/diagnóstico
Refluxo Gastroesofágico/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Transtornos da Motilidade Esofágica/complicações
Esfíncter Esofágico Inferior/fisiologia
Monitoramento do pH Esofágico
Junção Esofagogástrica/fisiologia
Esofagoscopia
Feminino
Refluxo Gastroesofágico/complicações
Refluxo Gastroesofágico/tratamento farmacológico
Seres Humanos
Masculino
Manometria
Meia-Idade
Peristaltismo
Inibidores da Bomba de Prótons/uso terapêutico
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.4166/kjg.2017.69.4.212


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[PMID]:28528063
[Au] Autor:Mege D; Benezech A; de Lesquen H; Vitton V; Thomas PA
[Ad] Endereço:Department of Thoracic Surgery, North Hospital, Aix-Marseille University and Assistance Publique-Hôpitaux de Marseille, Marseille, France.
[Ti] Título:An Involuntary and Unexpected Treatment of Nutcracker Esophagus.
[So] Source:Ann Thorac Surg;103(6):e545-e547, 2017 Jun.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A 76-year-old woman complained of painful dysphagia and loss of weight. Esophagoscopy results were negative, whereas computed tomography (CT) disclosed a 25-mm mediastinal tumor without a connection to the esophagus. A diagnosis of nutcracker esophagus was made on high-resolution esophageal manometry. Peroral endoscopic esophageal myotomy failed to improve the symptoms. Right video thoracoscopy allowed resection of the tumor, which looked like a neurogenic tumor of the posterior mediastinum that developed from the right vagus nerve. The patient's dysphagia dramatically improved postoperatively. Because the pathologic examination disclosed a benign solitary fibrous tumor of the pleura, we hypothesize that the motility disorder would have been resolved by the unilateral vagotomy.
[Mh] Termos MeSH primário: Transtornos da Motilidade Esofágica/terapia
Vagotomia
[Mh] Termos MeSH secundário: Idoso
Transtornos de Deglutição/etiologia
Transtornos da Motilidade Esofágica/complicações
Transtornos da Motilidade Esofágica/diagnóstico por imagem
Esofagoscopia
Esôfago/cirurgia
Feminino
Seres Humanos
Manometria
Neoplasias do Mediastino/complicações
Neoplasias do Mediastino/cirurgia
Tumor Fibroso Solitário Pleural/complicações
Tumor Fibroso Solitário Pleural/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


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[PMID]:28375487
[Au] Autor:Schlottmann F; Shaheen NJ; Madanick RD; Patti MG
[Ad] Endereço:Departments of 1Surgery and Center for Esophageal Diseases and Swallowing.
[Ti] Título:The role of Heller myotomy and POEM for nonachalasia motility disorders.
[So] Source:Dis Esophagus;30(4):1-5, 2017 Apr 01.
[Is] ISSN:1442-2050
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The best-defined primary esophageal motor disorder is achalasia. However, symptoms such as dysphagia, regurgitation and chest pain can be caused by other esophageal motility disorders such as Diffuse Esophageal Spasm (DES), Nutcracker Esophagus (NE) and the Hypertensive Lower Esophageal Sphincter (HTN-LES). Most patients with DES and HTN-LES who complain of dysphagia improve after a myotomy. Patients with NE whose main complaint is chest pain, often do not have relief of the pain and can even develop dysphagia as a consequence of the myotomy. POEM is a relatively new procedure, and there are no studies with long-term follow-up and no prospective and randomized trials comparing it to surgical myotomy. Overall, the key to success is based on a complete evaluation and a careful patient selection. The best results, regardless of the technique, are in fact obtained in patients with outflow obstruction and impaired esophageal emptying, a picture similar to achalasia.
[Mh] Termos MeSH primário: Transtornos da Motilidade Esofágica/cirurgia
Espasmo Esofágico Difuso/cirurgia
Esôfago/cirurgia
Hipertensão/cirurgia
Cirurgia Endoscópica por Orifício Natural/métodos
[Mh] Termos MeSH secundário: Esfíncter Esofágico Inferior/cirurgia
Fundoplicatura/métodos
Seres Humanos
Laparoscopia/métodos
Boca/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1093/dote/dox003


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[PMID]:28365899
[Au] Autor:Edeani F; Malik A; Kaul A
[Ad] Endereço:Department of Internal Medicine, Good Samaritan Hospital, Cincinnati, OH, 45220, USA.
[Ti] Título:Characterization of Esophageal Motility Disorders in Children Presenting With Dysphagia Using High-Resolution Manometry.
[So] Source:Curr Gastroenterol Rep;19(3):13, 2017 Mar.
[Is] ISSN:1534-312X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The Chicago classification was based on metrics derived from studies in asymptomatic adult subjects. Our objectives were to characterize esophageal motility disorders in children and to determine whether the spectrum of manometric findings is similar between the pediatric and adult populations. RECENT FINDINGS: Studies have suggested that the metrics utilized in manometric diagnosis depend on age, size, and manometric assembly. This would imply that a different set of metrics should be used for the pediatric population. There are no standardized and generally accepted metrics for use in the pediatric population, though there have been attempts to establish metrics specific to this population. Overall, we found that the distribution of esophageal motility disorders in children was like that described in adults using the Chicago classification. This analysis will serve as a prequel to follow-up studies exploring the individual metrics for variability among patients, with the objective of establishing novel metrics for the pediatric population.
[Mh] Termos MeSH primário: Transtornos de Deglutição/etiologia
Transtornos da Motilidade Esofágica/complicações
Transtornos da Motilidade Esofágica/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Criança
Pré-Escolar
Esôfago/fisiopatologia
Feminino
Seres Humanos
Lactente
Masculino
Manometria/métodos
Processamento de Sinais Assistido por Computador
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE
[do] DOI:10.1007/s11894-017-0549-x


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[PMID]:28268032
[Au] Autor:Pérez Y López N; Lugo-Zamudio G; Barbosa-Cobos RE; Wong-Lam A; Torres-López E
[Ad] Endereço:Laboratorio de Motilidad Gastrointestinal y Clínica de ERGE y trastornos funcionales digestivos, Hospital Juárez de México, SSA, Ciudad de México, México. Electronic address: sonelle74@hotmail.com.
[Ti] Título:Frequency of motor alterations detected through manometry in patients with esophageal symptoms and scleroderma.
[Ti] Título:Frecuencia de alteraciones motoras detectadas por manometría en pacientes con síntomas esofágicos y esclerodermia..
[So] Source:Rev Gastroenterol Mex;82(2):193-195, 2017 Apr - Jun.
[Is] ISSN:0375-0906
[Cp] País de publicação:Mexico
[La] Idioma:eng; spa
[Ab] Resumo:BACKGROUND: Scleroderma can present with esophageal involvement causing important morbidity. AIMS: To describe the manometric findings and clinical characteristics of patients with scleroderma and esophageal symptoms. MATERIALS AND METHODS: Patients with scleroderma and esophageal symptoms were evaluated through esophageal manometry within the time frame of one year. Descriptive statistics were carried out and the continuous variables were expressed as means and standard deviation. Frequencies were expressed as percentages. RESULTS: The study included 24 female patients with a mean age of 53.5 years and mean disease progression of 7.84 years. The most frequent findings were short and hypotonic lower esophageal sphincter (mean length 1.58cm and mean tone 9.49mmHg) and ineffective esophageal motility (mean non-transmitted waves 92.91%, mean effective primary peristalsis 40.05%, and mean amplitude 13.11mmHg). The most frequent symptom was dysphagia. CONCLUSIONS: Scleroderma is associated with lower esophageal sphincter alterations and symptomatic ineffective esophageal motility.
[Mh] Termos MeSH primário: Transtornos da Motilidade Esofágica/complicações
Escleroderma Sistêmico/complicações
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Progressão da Doença
Transtornos da Motilidade Esofágica/diagnóstico
Transtornos da Motilidade Esofágica/fisiopatologia
Esfíncter Esofágico Inferior/fisiopatologia
Feminino
Seres Humanos
Masculino
Manometria
Meia-Idade
Escleroderma Sistêmico/diagnóstico
Escleroderma Sistêmico/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE


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[PMID]:28246468
[Au] Autor:Rouphael C; Gordon IO; Thota PN
[Ad] Endereço:Carol Rouphael, Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
[Ti] Título:Lymphocytic esophagitis: Still an enigma a decade later.
[So] Source:World J Gastroenterol;23(6):949-956, 2017 Feb 14.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity.
[Mh] Termos MeSH primário: Transtornos da Motilidade Esofágica/complicações
Esofagite/etiologia
Refluxo Gastroesofágico/complicações
Linfocitose/etiologia
[Mh] Termos MeSH secundário: Biópsia
Toxinas Botulínicas Tipo A/uso terapêutico
Endoscopia
Esofagite/diagnóstico
Esofagite/tratamento farmacológico
Esofagite/patologia
Glucocorticoides/uso terapêutico
Seres Humanos
Linfocitose/diagnóstico
Linfocitose/tratamento farmacológico
Linfocitose/patologia
Inibidores da Bomba de Prótons/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Proton Pump Inhibitors); E211KPY694 (onabotulinumtoxinA); EC 3.4.24.69 (Botulinum Toxins, Type A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i6.949


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[PMID]:28220362
[Au] Autor:Ahuja NK; Clarke JO
[Ad] Endereço:Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 1800 Orleans St, Baltimore, MD, 21287, USA.
[Ti] Título:The Role of Impedance Planimetry in the Evaluation of Esophageal Disorders.
[So] Source:Curr Gastroenterol Rep;19(2):7, 2017 Feb.
[Is] ISSN:1534-312X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Impedance planimetry measures tissue wall distensibility as a function of pressure and cross-sectional area. Recent interest in this technique's relevance to the gastrointestinal tract has been accelerated by the availability of the functional lumen imaging probe, a catheter-based system that dynamically quantitates these biomechanical properties. Herein, we review the device's particular utility in the setting of esophageal pathology, including processes affecting the esophageal body as well as the upper and lower esophageal sphincters. RECENT FINDINGS: An expanding suite of disease-specific indications for impedance planimetry includes achalasia, gastroesophageal reflux disease, and eosinophilic esophagitis. The technique has also demonstrated a role in the intraoperative guidance of therapy and in the definition of hitherto unrecognized patterns of esophageal dysmotility. Device-specific technology remains in active evolution, which, in conjunction with progressively larger datasets, sets the stage for broader clinical applicability in the near future.
[Mh] Termos MeSH primário: Doenças do Esôfago/diagnóstico
[Mh] Termos MeSH secundário: Impedância Elétrica
Esofagite Eosinofílica/diagnóstico
Esofagite Eosinofílica/fisiopatologia
Acalasia Esofágica/diagnóstico
Acalasia Esofágica/fisiopatologia
Doenças do Esôfago/fisiopatologia
Transtornos da Motilidade Esofágica/diagnóstico
Transtornos da Motilidade Esofágica/fisiopatologia
Junção Esofagogástrica/fisiopatologia
Fundoplicatura
Refluxo Gastroesofágico/diagnóstico
Refluxo Gastroesofágico/fisiopatologia
Refluxo Gastroesofágico/cirurgia
Seres Humanos
Manometria/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1007/s11894-017-0544-2


  10 / 1631 MEDLINE  
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[PMID]:28161707
[Au] Autor:Kawami N; Takenouchi N; Umezawa M; Hoshino S; Hanada Y; Hoshikawa Y; Sano H; Hoshihara Y; Nomura T; Uchida E; Iwakiri K
[Ad] Endereço:Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
[Ti] Título:Pathogenesis of Double-Dose Proton Pump Inhibitor-Resistant Non-Erosive Reflux Disease, and Mechanism of Reflux Symptoms and Gastric Acid Secretion-Suppressive Effect in the Presence or Absence of Helicobacter pylori Infection.
[So] Source:Digestion;95(2):140-145, 2017.
[Is] ISSN:1421-9867
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Various mechanisms have been suggested to be responsible for contributing to the occurrence of proton pump inhibitor (PPI)-resistant non-erosive reflux disease (NERD). The aims of this study were to clarify the pathogenesis of PPI-resistant NERD. METHODS: Fifty-three patients with NERD, who had persistent reflux symptoms despite taking double-dose PPI, were included in this study. After excluding eosinophilic esophagitis (EoE) and primary esophageal motility disorder, esophageal impedance-pH monitoring was carried out. In symptom index (SI)-positive patients, the mechanism of SI positivity and the percent time with intragastric pH >4 were investigated according to the presence or absence of Helicobacter pylori infection. RESULTS: One of the 53 patients had EoE, and 4 had primary esophageal motility disorder. Twenty-three and 2 patients were SI-positive for liquid and gas-only reflux respectively. Of 17 SI-positive, H. pylori-negative patients, 5 were SI-positive for acid reflux, whereas all of the H. pylori-positive patients were SI-positive for non-acid reflux. The percent time with intragastric pH >4 was significantly lower in the H. pylori-negative patients than in the H. pylori-positive patients. CONCLUSIONS: The pathogenesis of double-dose PPI-resistant NERD was identified in 57%. In some of H. pylori-negative patients, acid-related symptoms were observed. However, in H. pylori-positive patients, these symptoms were excluded by taking double-dose PPI.
[Mh] Termos MeSH primário: Resistência a Medicamentos
Ácido Gástrico/secreção
Refluxo Gastroesofágico/tratamento farmacológico
Refluxo Gastroesofágico/etiologia
Infecções por Helicobacter/diagnóstico
Inibidores da Bomba de Prótons/farmacologia
[Mh] Termos MeSH secundário: Esofagite Eosinofílica/diagnóstico
Transtornos da Motilidade Esofágica/diagnóstico
Monitoramento do pH Esofágico
Feminino
Refluxo Gastroesofágico/diagnóstico
Infecções por Helicobacter/microbiologia
Helicobacter pylori/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Inibidores da Bomba de Prótons/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE
[do] DOI:10.1159/000455834



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