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[PMID]:28461205
[Au] Autor:Supadej K; Khamrin P; Kumthip K; Kochjan P; Yodmeeklin A; Ushijima H; Maneekarn N
[Ad] Endereço:Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
[Ti] Título:Wide variety of recombinant strains of norovirus GII in pediatric patients hospitalized with acute gastroenteritis in Thailand during 2005 to 2015.
[So] Source:Infect Genet Evol;52:44-51, 2017 Aug.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Norovirus (NoV) has been reported as being a common cause of acute gastroenteritis both in children and adults worldwide. Of the many variants, NoV GII.4 is the most predominant genotype. One of the mechanisms that drives the evolution and emergence of new variants of NoV is homologous recombination. This study describes the genetic recombination involved in cases of NoV GII detected in pediatric patients with acute gastroenteritis in Chiang Mai, Thailand during 2005 to 2015. From a total of 1938 stool samples, 3 (0.15%) were positive for NoV GI and 298 (15.38%) were identified as NoV GII. The genotypes detected in this study were GI.6, GI.14, GII.1, GII.2, GII.3, GII.4, GII.6, GII.7, GII.12, GII.13, GII.14, GII.15, GII.16, GII.17, GII.20, and GII.21. The NoV recombinant strains were verified by analysis of the partial sequence of ORF1 (RdRp)/ORF2 (capsid) junction. Phylogenetic analyses of partial ORF1 and ORF2 regions resulted in the identification of 21 (6.98%) NoV recombinant strains. Among these, 9 recombination patterns were detected in this study; GII.Pe/GII.4, GII.Pg/GII.1, GII.Pg/GII.12, GII.P7/GII.6, GII.P7/GII.14, GII.P12/GII.4, GII.P16/GII.2, GII.P16/GII.13, and GII.P21/GII.3. The findings demonstrated the wide variety of recombinant strains of NoV GII strains detected in pediatric patients admitted to the hospitals with acute gastroenteritis in Chiang Mai, Thailand during the past decade.
[Mh] Termos MeSH primário: Infecções por Caliciviridae/diagnóstico
Gastroenterite/virologia
Norovirus/genética
[Mh] Termos MeSH secundário: Criança
Evolução Molecular
Genótipo
Hospitalização
Seres Humanos
Norovirus/classificação
Filogenia
Recombinação Genética
Tailândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28450084
[Au] Autor:Bodnar L; Lorusso E; Di Martino B; Catella C; Lanave G; Elia G; Bányai K; Buonavoglia C; Martella V
[Ad] Endereço:University Aldo Moro of Bari, Valenzano, Italy.
[Ti] Título:Identification of a novel canine norovirus.
[So] Source:Infect Genet Evol;52:75-81, 2017 Aug.
[Is] ISSN:1567-7257
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:By screening a collection of fecal samples from young dogs from different European countries, noroviruses (NoVs) were found in 13/294 (4.4%) animals with signs of enteritis whilst they were not detected in healthy dogs (0/42). An informative portion of the genome (3.4kb at the 3' end) was generated for four NoV strains. In the capsid protein VP1 region, strains 63.15/2015/ITA and FD53/2007/ITA were genetically related to the canine GVI.2 strain C33/Viseu/2007/PRT (97.4-98.6% nt and 90.3-98.6% aa). Strain FD210/2007/ITA displayed the highest identity to the GVI.1 canine strain Bari/91/2007/ITA (88.0% nt and 95.0% aa). Strain 5010/2009/ITA displayed only 66.6-67.6% nt and 75.5-81.6% aa identities to the GVI.1 canine strains FD210/2007/ITA and Bari/91/2007/ITA and the GVI feline strain M49-1/2012/JPN. Identity to the other canine/feline NoVs strains in the VP1 was lower than 67.6% nt and 62.7% aa. Based on the full-length VP1 amino acid sequence and the criteria proposed for distinction of NoV genotypes, the canine NoV 5010/2009/ITA could represent the prototype of a third GVI genotype, thus providing further evidence for the genetic heterogeneity of NoVs in carnivores.
[Mh] Termos MeSH primário: Infecções por Caliciviridae/veterinária
Doenças do Cão/virologia
Gastroenterite/veterinária
Norovirus/classificação
[Mh] Termos MeSH secundário: Animais
Infecções por Caliciviridae/diagnóstico
Infecções por Caliciviridae/epidemiologia
Doenças do Cão/epidemiologia
Cães
Europa (Continente)/epidemiologia
Evolução Molecular
Fezes/virologia
Gastroenterite/virologia
Genoma Viral
Norovirus/genética
Norovirus/isolamento & purificação
Filogenia
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29466164
[Au] Autor:Bines JE; At Thobari J; Satria CD; Handley A; Watts E; Cowley D; Nirwati H; Ackland J; Standish J; Justice F; Byars G; Lee KJ; Barnes GL; Bachtiar NS; Viska Icanervilia A; Boniface K; Bogdanovic-Sakran N; Pavlic D; Bishop RF; Kirkwood CD; Buttery JP; Soenarto Y
[Ad] Endereço:From the RV3 Rotavirus Vaccine Program, Murdoch Children's Research Institute (J.E.B., A.H., E.W., D.C., J.S., F.J., G.B., K.J.L., G.L.B., K.B., N.B.-S., D.P., R.F.B., C.D.K., J.P.B.), the Department of Paediatrics, University of Melbourne (J.E.B., D.C., K.J.L., G.L.B., R.F.B., C.D.K., J.P.B.), and
[Ti] Título:Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth.
[So] Source:N Engl J Med;378(8):719-730, 2018 02 22.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: A strategy of administering a neonatal rotavirus vaccine at birth to target early prevention of rotavirus gastroenteritis may address some of the barriers to global implementation of a rotavirus vaccine. METHODS: We conducted a randomized, double-blind, placebo-controlled trial in Indonesia to evaluate the efficacy of an oral human neonatal rotavirus vaccine (RV3-BB) in preventing rotavirus gastroenteritis. Healthy newborns received three doses of RV3-BB, administered according to a neonatal schedule (0 to 5 days, 8 weeks, and 14 weeks of age) or an infant schedule (8 weeks, 14 weeks, and 18 weeks of age), or placebo. The primary analysis was conducted in the per-protocol population, which included only participants who received all four doses of vaccine or placebo within the visit windows, with secondary analyses performed in the intention-to-treat population, which included all participants who underwent randomization. RESULTS: Among the 1513 participants in the per-protocol population, severe rotavirus gastroenteritis occurred up to the age of 18 months in 5.6% of the participants in the placebo group (28 of 504 babies), in 1.4% in the neonatal-schedule vaccine group (7 of 498), and in 2.7% in the infant-schedule vaccine group (14 of 511). This resulted in a vaccine efficacy of 75% (95% confidence interval [CI], 44 to 91) in the neonatal-schedule group (P<0.001), 51% (95% CI, 7 to 76) in the infant-schedule group (P=0.03), and 63% (95% CI, 34 to 80) in the neonatal-schedule and infant-schedule groups combined (combined vaccine group) (P<0.001). Similar results were observed in the intention-to-treat analysis (1649 participants); the vaccine efficacy was 68% (95% CI, 35 to 86) in the neonatal-schedule group (P=0.001), 52% (95% CI, 11 to 76) in the infant-schedule group (P=0.02), and 60% (95% CI, 31 to 76) in the combined vaccine group (P<0.001). Vaccine response, as evidenced by serum immune response or shedding of RV3-BB in the stool, occurred in 78 of 83 participants (94%) in the neonatal-schedule group and in 83 of 84 participants (99%) in the infant-schedule group. The incidence of adverse events was similar across the groups. No episodes of intussusception occurred within the 21-day risk period after administration of any dose of vaccine or placebo, and one episode of intussusception occurred 114 days after the third dose of vaccine in the infant-schedule group. CONCLUSIONS: RV3-BB was efficacious in preventing severe rotavirus gastroenteritis when administered according to a neonatal or an infant schedule in Indonesia. (Funded by the Bill and Melinda Gates Foundation and others; Australian New Zealand Clinical Trials Registry number, ACTRN12612001282875 .).
[Mh] Termos MeSH primário: Gastroenterite/prevenção & controle
Infecções por Rotavirus/prevenção & controle
Vacinas contra Rotavirus/imunologia
[Mh] Termos MeSH secundário: Administração Oral
Método Duplo-Cego
Fezes/virologia
Feminino
Gastroenterite/epidemiologia
Gastroenterite/virologia
Seres Humanos
Esquemas de Imunização
Indonésia
Lactente
Recém-Nascido
Análise de Intenção de Tratamento
Masculino
Rotavirus/isolamento & purificação
Vacinas contra Rotavirus/administração & dosagem
Vacinas contra Rotavirus/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RV3 rotavirus vaccine); 0 (Rotavirus Vaccines)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMoa1706804


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[PMID]:29196818
[Au] Autor:Kikuchi W; Nakagomi T; Gauchan P; Agbemabiese CA; Noguchi A; Nakagomi O; Takahashi T
[Ad] Endereço:Department of Paediatrics, Akita University Graduate School of Medicine, Akita, Japan.
[Ti] Título:Detection in Japan of an equine-like G3P[8] reassortant rotavirus A strain that is highly homologous to European strains across all genome segments.
[So] Source:Arch Virol;163(3):791-794, 2018 Mar.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Equine-like G3P[8] rotavirus A strains with DS-1-like backbone genes have emerged since 2013. An equine-like RVA/Human-wt/JPN/15R429/2015/G3P[8] strain possessing I2-R2-C2-M2-A2-N2-T2-E2-H2 was detected in Japan in 2015. Its VP7 gene was ≥ 99.3% identical to those of equine-like G3P[4] strains detected in Japan, and the remaining 10 genes were 98.6-99.8% identical to G1P[8] double-gene reassortants detected in Japan, Thailand and the Philippines. Thus, 15R429 was likely generated through reassortment between the equine-like G3P[4] and G1P[8] reassortant strains. Notably, 15R429 was 98.5-99.8% identical across all 11 genes of the equine-like G3P[8] strains detected in Spain and Hungary in 2015.
[Mh] Termos MeSH primário: Antígenos Virais/genética
Proteínas do Capsídeo/genética
Gastroenterite/veterinária
Doenças dos Cavalos/epidemiologia
Filogenia
Vírus Reordenados/genética
Infecções por Rotavirus/veterinária
Rotavirus/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Europa (Continente)/epidemiologia
Gastroenterite/epidemiologia
Gastroenterite/virologia
Expressão Gênica
Sequenciamento de Nucleotídeos em Larga Escala
Doenças dos Cavalos/virologia
Cavalos/virologia
Seres Humanos
Japão/epidemiologia
Vírus Reordenados/classificação
Vírus Reordenados/isolamento & purificação
Rotavirus/classificação
Rotavirus/isolamento & purificação
Infecções por Rotavirus/epidemiologia
Infecções por Rotavirus/virologia
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Viral); 0 (Capsid Proteins); 0 (VP7 protein, Rotavirus)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3668-7


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[PMID]:28449729
[Au] Autor:Bidalot M; Théry L; Kaplon J; De Rougemont A; Ambert-Balay K
[Ad] Endereço:National Reference Centre for Gastroenteritis Viruses, Laboratory of Biology and Pathology, University Hospital Dijon Bourgogne, Dijon, France.
[Ti] Título:Emergence of new recombinant noroviruses GII.p16-GII.4 and GII.p16-GII.2, France, winter 2016 to 2017.
[So] Source:Euro Surveill;22(15), 2017 Apr 13.
[Is] ISSN:1560-7917
[Cp] País de publicação:Sweden
[La] Idioma:eng
[Ab] Resumo:An early increase in outbreaks of norovirus gastroenteritis characterised at the French National Reference Centre occurred this winter season. They were concurrent with an unusual pattern of circulating strains, with three predominant genotypes: the re-emergent variant GII.P4 2009-GII.4 2012 found in 28% of norovirus outbreaks and two new emergent recombinant strains GII.P16-GII.4 2012 and GII.P16-GII.2 never before observed in France, found in 24% and 14% of norovirus outbreaks, respectively.
[Mh] Termos MeSH primário: Infecções por Caliciviridae/virologia
Doenças Transmissíveis Emergentes/epidemiologia
Doenças Transmissíveis Emergentes/virologia
Gastroenterite/epidemiologia
Gastroenterite/virologia
Norovirus/genética
Estações do Ano
[Mh] Termos MeSH secundário: Infecções por Caliciviridae/epidemiologia
Fezes/virologia
França/epidemiologia
Seres Humanos
Norovirus/isolamento & purificação
Vírus Reordenados/genética
Vírus Reordenados/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:27771186
[Au] Autor:Muhsen K; Kassem E; Rubenstein U; Goren S; Ephros M; Cohen D; Shulman LM
[Ad] Endereço:Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel. Electronic address: kmuhsen@post.tau.ac.il.
[Ti] Título:Incidence of rotavirus gastroenteritis hospitalizations and genotypes, before and five years after introducing universal immunization in Israel.
[So] Source:Vaccine;34(48):5916-5922, 2016 11 21.
[Is] ISSN:1873-2518
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Uncertainty exists about the sustainability of the reduction in rotavirus gastroenteritis (RVGE) following the introduction of rotavirus vaccines into national immunization programs, and on its potential impact on circulating genotypes. RotaTeq was introduced into the Israeli national immunization program in December 2010, and vaccination coverage is around 80%. AIMS: To examine the change in incidence of RVGE hospitalization and rotavirus genotypes, during the five years after introduction of RotaTeq into the Israeli national immunization program. METHODS: Data were obtained prospectively on hospitalization of children aged 0-59months due to acute gastroenteritis (N=7346) from three hospitals in northern Israel. Stool samples were tested for rotavirus by immunochromatography. Rotavirus was genotyped (N=506) by RT-PCR and/or sequencing. RESULTS: The average incidence of RVGE hospitalization declined by 61.0% (95% CI 49.0-73.4%), from 5.6 per 1000 (95% CI 5.0-6.2) in the pre-universal immunization period (2008-2010) to 2.2 per 1000 (95% CI 1.8-2.5) during the universal immunization period (2012-2015), but yearly fluctuations were still observed. The most common genotypes in the pre-universal immunization period were G1P[8] (35.3%) followed by G2P[4] (15.5%), G3P[8] (8.8%), G4P[8] (4.3%) and G9P[8] (4.3%), and 19.5% were mixed infections. The dominance of G1P[8] continued into the universal immunization period (48.6%), followed by G3P[8] (21.5%), G9P[8] (15.9%) and G12P[8] (4.7%), while mixed rotavirus infections were no longer detected. CONCLUSIONS: Universal immunization with RotaTeq in Israel was associated a sustained reduction in RVGE hospitalization. It is unclear whether changes in the circulating rotavirus genotypes are due to vaccine-induced selective pressure. Assessment of the long-term impact of rotavirus vaccination on the incidence of rotavirus gastroenteritis and continued strain surveillance is warranted.
[Mh] Termos MeSH primário: Gastroenterite/epidemiologia
Hospitalização/estatística & dados numéricos
Vacinação em Massa
Infecções por Rotavirus/epidemiologia
Vacinas contra Rotavirus/administração & dosagem
Cobertura Vacinal
[Mh] Termos MeSH secundário: Pré-Escolar
Fezes/virologia
Feminino
Gastroenterite/virologia
Genótipo
Seres Humanos
Imunocromatografia
Incidência
Lactente
Recém-Nascido
Israel/epidemiologia
Masculino
Estudos Prospectivos
Rotavirus/genética
Infecções por Rotavirus/diagnóstico
Infecções por Rotavirus/virologia
Fatores de Tempo
Vacinas Atenuadas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RotaTeq); 0 (Rotavirus Vaccines); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29284004
[Au] Autor:Fu JG; Shi C; Xu C; Lin Q; Zhang J; Yi QH; Zhang J; Bao CJ; Huo X; Zhu YF; Ai J; Xing Z
[Ad] Endereço:Medical School and Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, China.
[Ti] Título:Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China.
[So] Source:PLoS One;12(12):e0186090, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A total of 64 acute gastroenteritis outbreaks with 2,953 patients starting in December of 2016 and occurring mostly in the late spring of 2017 were reported in Jiangsu, China. A recombinant GII.P16-GII.2 norovirus variant was associated with 47 outbreaks (73.4%) for the gastroenteritis epidemic, predominantly occurring in February and March of 2017. Sequence analysis of the RNA-dependent RNA polymerase (RdRp) and capsid protein of the viral isolates from these outbreaks confirmed that this GII.P16-GII.2 strain was the GII.P16-GII.2 variant with the intergenotypic recombination, identified in Taiwan, Hong Kong, and other cities in China in 2016. This GII.P16-GII.2 recombinant variant appeared to a re-emerging strain, firstly identified in 2011-2012 from Japan and USA but might be independently originated from other GII.P16-GII.2 variants for sporadic and outbreaks of gastroenteritis in Japan and China before 2016. Further identification of unique amino acid mutations in both VP1 and RdRp of NoV strain as shown in this report may provide insight in explaining its structural and antigenic changes, potentially critical for the variant recombinant to gain its predominance in causing regional and worldwide epidemics.
[Mh] Termos MeSH primário: Infecções por Caliciviridae/epidemiologia
Surtos de Doenças
Gastroenterite/epidemiologia
Norovirus/isolamento & purificação
[Mh] Termos MeSH secundário: Doença Aguda
China/epidemiologia
Genes Virais
Seres Humanos
Norovirus/classificação
Norovirus/genética
Norovirus/patogenicidade
Filogenia
Proteínas Virais/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Viral Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186090


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[PMID]:28746261
[Au] Autor:McAuliffe GN; Taylor SL; Drinkovic D; Roberts SA; Wilson EM; Best EJ
[Ad] Endereço:From the *Microbiology Department, Auckland City Hospital, †Microbiology Department, Middlemore Hospital, ‡Microbiology Department, North Shore Hospital, and §Department of Paediatric Infectious Diseases, Starship Children's Hospital, Auckland, New Zealand.
[Ti] Título:Rotavirus Infection in the Auckland Region After the Implementation of Universal Infant Rotavirus Vaccination: Impact on Hospitalizations and Laboratory Implications.
[So] Source:Pediatr Infect Dis J;37(1):e1-e5, 2018 Jan.
[Is] ISSN:1532-0987
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In July 2014, New Zealand introduced universal infant vaccination with RotaTeq (Merk & Co.) administered as 3 doses at 6 weeks, 3 and 5 months of age. We sought to assess the impact of rotavirus vaccination on gastroenteritis (GE) hospitalizations in the greater Auckland region and analyze changes in rotavirus testing in the period around vaccine introduction. METHODS: Hospitalizations, laboratory testing rates and methods were compared between the pre-vaccine period (2009-2013), post-vaccine period (January 2015 to December 2015) and year of vaccine introduction (2014). RESULTS: There was a 68% decline in rotavirus hospitalizations of children <5 years of age after vaccine introduction (from 258/100,000 to 83/100,000) and a 17% decline in all-cause gastroenteritis admissions (from 1815/100,000 to 1293/100,000). Reductions were also seen in pediatric groups too old to have received vaccine. Despite these changes, rotavirus testing rates in our region remained static in the year after vaccine introduction compared with the 2 prior years, and after vaccine introduction, we observed a high rate of false positives 19/58 (33%) in patients with reactive rotavirus tests. CONCLUSIONS: Rotavirus vaccine has had a significant early impact on gastroenteritis hospitalizations for children in the Auckland region. However, continued rotavirus testing at pre-vaccine rates risks generating false positive results. Laboratories and clinicians should consider reviewing their testing algorithms before vaccine introduction.
[Mh] Termos MeSH primário: Gastroenterite/epidemiologia
Hospitalização/estatística & dados numéricos
Técnicas Microbiológicas/estatística & dados numéricos
Infecções por Rotavirus/epidemiologia
Vacinas contra Rotavirus
Vacinação/estatística & dados numéricos
[Mh] Termos MeSH secundário: Pré-Escolar
Reações Falso-Positivas
Gastroenterite/prevenção & controle
Gastroenterite/virologia
Seres Humanos
Lactente
Recém-Nascido
Técnicas Microbiológicas/utilização
Nova Zelândia/epidemiologia
Rotavirus
Infecções por Rotavirus/prevenção & controle
Infecções por Rotavirus/virologia
Vacinas Atenuadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RotaTeq); 0 (Rotavirus Vaccines); 0 (Vaccines, Attenuated)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1097/INF.0000000000001706


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[PMID]:29255563
[Au] Autor:Adeniyi OF; Adenike Lesi O; Olatona FA; Esezobor CI; Ikobah JM
[Ad] Endereço:Department of Paediatrics, College of Medicine, University of Lagos,Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.
[Ti] Título:Irritable bowel syndrome in adolescents in Lagos.
[So] Source:Pan Afr Med J;28:93, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders (FGIDs) which has been well described in western populations especially as the commonest cause of recurrent abdominal pain The aim of this study was to document the prevalence of Irritable bowel syndrome (IBS) amongst children in western Nigeria and increase the aware ness of IBS amongst physicians who manage children with abdominal pain. Methods: This was a cross-sectional study conducted amongst children aged 10-18 years in 8 schools located in two local government areas of Lagos state. A multistage stratified random-sampling survey was conducted using the validated Rome III criteria to assess for IBS and associated risk factors. The subtypes of IBS and associated extra-intestinal symptoms were also documented. Results: The prevalence of IBS was 16.0% in the study participants and the prevalence decreased with increasing age (p=0.05). Sixty two (62.5%) of the students with recurrent abdominal pain had IBS. IBS was more prevalent in the females compared to the males (p=0.000). The significant risk factors for IBS identified were gender (p=0.000), socioeconomic status (p=0.001) and past history of gastroenteritis (p=0.011). The commonest subtype of IBS seen was the alternating subtype. Conclusion: IBS is prevalent in African children. Physicians who attend to children need to have a high index of suspicion for IBS in children who present with abdominal pain when there are no alarm symptoms. The need for further longitudinal studies in African children cannot be overemphasized.
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Gastroenterite/epidemiologia
Síndrome do Intestino Irritável/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Fatores Etários
Criança
Estudos Transversais
Feminino
Seres Humanos
Masculino
Nigéria/epidemiologia
Prevalência
Fatores de Risco
Fatores Sexuais
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.93.11512


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[PMID]:29255557
[Au] Autor:Magzoub MA; Bilal NE; Bilal JA; Alzohairy MA; Elamin BK; Gasim GI
[Ad] Endereço:National Public Health Laboratory, Ministry of Health, Khartoum, Sudan.
[Ti] Título:Detection and sequencing of rotavirus among sudanese children.
[So] Source:Pan Afr Med J;28:87, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Introduction: Diarrheal diseases are a big public health problem worldwide, particularly among developing countries. The current study was conducted to detect and characterize group A rotavirus among admitted children with gastroenteritis to the pediatric hospitals, Sudan. Methods: A total of 755 stool samples were collected from Sudanese children with less than 5 years of age presenting with acute gastroenteritis during the period from April to September 2010. Enzyme-linked immunosorbent assay (ELISA) was used to Detection of Rotavirus antigens. Ribonucleic acid (RNAs) were extracted from rotavirus-positive stool samples using (QIAamp Viral RNA Mini Kit). (Omniscript Reverse Transcription kit) was used to convert RNA to complementary Deoxyribonucleic acid (cDNA). The cDNAs were used as template for detection of VP4-P (P for Protease-sensitive) and VP7-G (G for Glycoprotein) genotyping of Rotavirus using nested PCR and sequencing. Results: Out of the 755 stool samples from children with acute gastroenteritis, 121 were positive for rotavirus A. Among 24 samples that were sequenced; the VP7 predominant G type was G1 (83.3%), followed by G9 (16.7%). Out of these samples, only one VP4 P[8] genotype was detected. Conclusion: As a conclusion the VP7 predominant G type was G1, followed by G9 whereas only one VP4 genotype was detected and showed similarity to P[8] GenBank strain. It appears that the recently approved rotavirus vaccines in Sudan are well matched to the rotavirus genotypes identified in this study, though more studies are needed.
[Mh] Termos MeSH primário: Diarreia/epidemiologia
Gastroenterite/epidemiologia
Infecções por Rotavirus/epidemiologia
Rotavirus/genética
[Mh] Termos MeSH secundário: Doença Aguda
Pré-Escolar
Estudos Transversais
Diarreia/virologia
Ensaio de Imunoadsorção Enzimática/métodos
Feminino
Gastroenterite/diagnóstico
Gastroenterite/virologia
Genótipo
Seres Humanos
Lactente
Masculino
Reação em Cadeia da Polimerase
Rotavirus/isolamento & purificação
Infecções por Rotavirus/diagnóstico
Infecções por Rotavirus/virologia
Sudão/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.28.87.11008



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