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[PMID]:28597107
[Au] Autor:Li J; Yan Y; Meng Z; Liu S; Beck PL; Ghosh S; Qian J; Gui X
[Ad] Endereço:Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China.
[Ti] Título:Microscopic Colitis Evolved Into Inflammatory Bowel Diseases Is Characterized by Increased Th1/Tc1 Cells in Colonic Mucosal Lamina Propria.
[So] Source:Dig Dis Sci;62(10):2755-2767, 2017 Oct.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An association between microscopic colitis (MC), i.e., lymphocytic colitis (LC) and collagenous colitis (CC), and inflammatory bowel diseases (IBD) has been noticed. A subset of MC cases may evolve into IBD, and IBD in remission may present as MC in a histologic pattern. Moreover, MC and IBD may coexist in different regions of the bowel. A link between MC and IBD in their pathogenesis is, therefore, suggested. Abnormal mucosal immunity is likely the key. METHODS: We reviewed 2324 MC cases in Calgary over 14 years and identified 20 cases evolved into IBD (IBD transformers). 13 of them were further investigated for colonic mucosal lamina propria mononuclear cells (LPMNCs), as opposed to 22 cases whose MC resolved. On their index colonic biopsy immunohistochemistry was performed to detect major T cell subsets characterized by key cytokines and master transcription factors (IFNγ and T-bet for Th1/Tc1, GATA-3 for Th2/Tc2, IL-17 and RORc for Th17/Tc17, FoxP3 for Treg/Tcreg) as well as TNFα cells (partly representing Th1). LPMNCs positive for each marker were counted (average number per high-power field). RESULTS: IBD transformers had increased IFNγ , T-bet , TNF-α , and GATA-3 LPMNCs compared to the MC-resolved cases. The LC-to-IBD subgroup had increased IFNγ and GATA-3 cells compared to the LC-resolved subgroup. The CC-to-IBD subgroup had increased T-bet , TNF-α , and GATA-3 cells compared to the CC-resolved subgroup. Among MC-resolved patients, more TNF-α and RORc cells were seen in LC than in CC. CONCLUSION: Th1/Tc1- and TNFα-producing cells, and likely a subset of Th2/Tc2 cells as well, may be involved in the MC-to-IBD transformation.
[Mh] Termos MeSH primário: Colite Microscópica/imunologia
Colo/imunologia
Imunidade nas Mucosas
Doenças Inflamatórias Intestinais/imunologia
Mucosa Intestinal/imunologia
Linfócitos T Citotóxicos/imunologia
Células Th1/imunologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Alberta
Biomarcadores/análise
Biópsia
Colite Microscópica/metabolismo
Colite Microscópica/patologia
Colo/química
Colo/patologia
Citocinas/análise
Progressão da Doença
Feminino
Seres Humanos
Imuno-Histoquímica
Doenças Inflamatórias Intestinais/metabolismo
Doenças Inflamatórias Intestinais/patologia
Mucosa Intestinal/química
Mucosa Intestinal/patologia
Masculino
Meia-Idade
Fenótipo
Linfócitos T Citotóxicos/química
Linfócitos T Citotóxicos/patologia
Células Th1/química
Células Th1/patologia
Fatores de Transcrição/análise
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cytokines); 0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-017-4636-5


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[PMID]:28350750
[Au] Autor:Wickbom A; Nyhlin N; Montgomery SM; Bohr J; Tysk C
[Ad] Endereço:aSchool of Medical Sciences, Örebro University, Örebro bThe Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden cDepartment of Epidemiology and Public Health, University College London, London, UK.
[Ti] Título:Family history, comorbidity, smoking and other risk factors in microscopic colitis: a case-control study.
[So] Source:Eur J Gastroenterol Hepatol;29(5):587-594, 2017 May.
[Is] ISSN:1473-5687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Data on heredity, risk factors and comorbidity in microscopic colitis, encompassing collagenous colitis (CC) and lymphocytic colitis (LC), are limited. AIM: The aim was to carry out a case-control study of family history, childhood circumstances, educational level, marital status, smoking and comorbidity in microscopic colitis. METHODS: A postal questionnaire was sent in 2008-2009 to microscopic colitis patients resident in Sweden and three population-based controls per patient, matched for age, sex and municipality. RESULTS: Some 212 patients and 627 controls participated in the study. There was an association with a family history of microscopic colitis in both CC [odds ratio (OR): 10.3; 95% confidence interval (CI): 2.1-50.4, P=0.004] and LC (OR not estimated, P=0.008). Current smoking was associated with CC [OR: 4.7; 95% CI: 2.4-9.2, P<0.001) and LC (OR: 3.2; 95% CI: 1.6-6.7, P=0.002). The median age at diagnosis was around 10 years earlier in ever-smokers compared with never-smokers.CC was associated with a history of ulcerative colitis (UC) (OR: 8.7, 95% CI: 2.2-33.7, P=0.002), thyroid disease (OR: 2.3; 95% CI: 1.1-4.5, P=0.02), coeliac disease (OR: 13.1; 95% CI: 2.7-62.7, P=0.001), rheumatic disease (OR 1.9; 95% CI: 1.0-3.5, P=0.042) and previous appendicectomy (OR: 2.2; 95% CI: 1.3-3.8, P=0.003), and LC with UC (OR: 6.8; 95% CI: 1.7-28.0, P=0.008), thyroid disease (OR: 2.4; 95% CI: 1.1-5.4, P=0.037) and coeliac disease (OR: 8.7; 95% CI: 2.8-26.7, P<0.001). CONCLUSION: Association with a family history of microscopic colitis indicates that familial factors may be important. The association with a history of UC should be studied further as it may present new insights into the pathogenesis of microscopic colitis and UC.
[Mh] Termos MeSH primário: Colite Microscópica/etiologia
Fumar/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Doenças Autoimunes/epidemiologia
Estudos de Casos e Controles
Colite Colagenosa/diagnóstico
Colite Colagenosa/epidemiologia
Colite Colagenosa/etiologia
Colite Colagenosa/genética
Colite Linfocítica/diagnóstico
Colite Linfocítica/epidemiologia
Colite Linfocítica/etiologia
Colite Linfocítica/genética
Colite Microscópica/diagnóstico
Colite Microscópica/epidemiologia
Colite Microscópica/genética
Colite Ulcerativa/epidemiologia
Comorbidade
Escolaridade
Feminino
Predisposição Genética para Doença
Seres Humanos
Masculino
Estado Civil
Meia-Idade
Fatores de Risco
Fumar/epidemiologia
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170329
[St] Status:MEDLINE
[do] DOI:10.1097/MEG.0000000000000832


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[PMID]:28265892
[Au] Autor:Cotter TG; Pardi DS
[Ad] Endereço:Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
[Ti] Título:Current Approach to the Evaluation and Management of Microscopic Colitis.
[So] Source:Curr Gastroenterol Rep;19(2):8, 2017 Feb.
[Is] ISSN:1534-312X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Microscopic colitis is a common cause of chronic watery diarrhea, particularly in the elderly. The accompanying symptoms, which include abdominal pain and fatigue, can markedly impair patients' quality of life. Diagnosis is based upon characteristic histologic findings of the colonic mucosa. This review focuses on the current approach to evaluation and management of patients with microscopic colitis. RECENT FINDINGS: Although the incidence of microscopic colitis has been increasing over time, recent epidemiological studies show stabilization at 21.0-24.7 cases per 100,000 person-years. Recent research has further expanded our knowledge of the underlying pathophysiology and emphasized the entity of drug-induced microscopic colitis and the association with celiac disease. Two recent randomized studies have confirmed the effectiveness of oral budesonide for both induction and maintenance treatment of microscopic colitis and is now endorsed by the American Gastroenterological Association as first-line treatment. The incidence of microscopic colitis has stabilized at just over 20 cases per 100,000 person-years. Celiac disease and drug-induced microscopic colitis should be considered in all patients diagnosed with microscopic colitis. There are a number of treatments available for patients with microscopic colitis; however, budesonide is the only option well studied in controlled trials and is effective for both induction and maintenance treatment.
[Mh] Termos MeSH primário: Colite Microscópica/diagnóstico
[Mh] Termos MeSH secundário: Budesonida/uso terapêutico
Colite Microscópica/complicações
Colite Microscópica/tratamento farmacológico
Diarreia/etiologia
Gerenciamento Clínico
Glucocorticoides/uso terapêutico
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Glucocorticoids); 51333-22-3 (Budesonide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170308
[St] Status:MEDLINE
[do] DOI:10.1007/s11894-017-0551-3


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[PMID]:28168580
[Au] Autor:Gentile NM; Yen EF
[Ad] Endereço:Division of Gastroenterology, NorthShore University HealthSystem, University of Chicago, Pritzker School of Medicine, 2650 Ridge Avenue, Suite G221, Evanston, IL, 60201, USA.
[Ti] Título:The Incidence of Microscopic Colitis: Microscopic No More.
[So] Source:Dig Dis Sci;62(6):1394-1395, 2017 06.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Colite Microscópica/epidemiologia
[Mh] Termos MeSH secundário: Seres Humanos
Incidência
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-017-4484-3


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[PMID]:28101837
[Au] Autor:Lucendo AJ
[Ad] Endereço:Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos s/n, Tomelloso, 13700, Ciudad Real, Spain. ajlucendo@hotmail.com.
[Ti] Título:Drug Exposure and the Risk of Microscopic Colitis: A Critical Update.
[So] Source:Drugs R D;17(1):79-89, 2017 Mar.
[Is] ISSN:1179-6901
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:A variety of luminal antigens, including a wide range of drugs, have been associated with the still little-known pathophysiology of microscopic colitis (MC), with variable evidence suggesting causality. This article aims to review the aspects related to drugs as potential triggers of MC; to discuss the most commonly identified associations between drugs and MC; and to analyze the limitations of the studies currently available. A literature search was performed in PubMed combining the search terms 'drug exposure', 'drug consumption', and 'risk factors' with 'microscopic colitis', 'lymphocytic colitis', and 'collagenous colitis', with no language restrictions. Reference lists of retrieved documents were also reviewed. A handful of case-control studies have demonstrated significant associations between some commonly used drugs and a higher risk of developing MC. No universally accepted criteria for establishing cause-effect relationships in adverse reactions to drugs are available, but several methods that can be applied to MC, can provide degrees of the likelihood of an association. A high probability imputation in the development of MC as a drug adverse effect has only been demonstrated for individual cases by applying chronological (challenge, de-challenge, and relapse with re-challenge) and semiological criteria. Several case-control studies have shown significant associations between exposure to drugs and MC, but the variability in their design, the reference populations used, and the definitions for drug exposure considered require specific analyses. It can be concluded that drug exposure and MC as a likely cause-effect relationship has only been described for a handful of drugs and in individual cases.
[Mh] Termos MeSH primário: Colite Microscópica/induzido quimicamente
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Preparações Farmacêuticas/administração & dosagem
[Mh] Termos MeSH secundário: Seres Humanos
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1007/s40268-016-0171-7


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[PMID]:28070826
[Au] Autor:Sonnenberg A; Turner KO; Genta RM
[Ad] Endereço:Miraca Life Sciences, Irving, TX, USA. sonnenbe@ohsu.edu.
[Ti] Título:Interaction of Ethnicity and H. pylori Infection in the Occurrence of Microscopic Colitis.
[So] Source:Dig Dis Sci;62(4):1009-1015, 2017 Apr.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Previous studies found that microscopic colitis is inversely associated with Helicobacter pylori infection and that microscopic colitis is characterized by a marked ethnic variation. AIM: The aim of the present study was to test whether an underlying ethnic variation of H. pylori infection is responsible for the ethnic variation of microscopic colitis. METHODS: The Miraca Life Sciences Database is a large national electronic repository of histopathologic records of patients distributed throughout the entire USA. A cross-sectional study evaluated the influence of age, gender, ethnicity, and histologic diagnosis of H. pylori on the occurrence of microscopic colitis among subjects who underwent esophago-gastro-duodenoscopies plus colonoscopy. RESULTS: The total study population comprised 228,506 subjects, of whom 28,890 carried a diagnosis of H. pylori gastritis and 3460 microscopic colitis. Female sex, old age, and H. pylori infection exerted the strongest influence on the occurrence of microscopic colitis. In comparison with the population comprising Caucasians and African-Americans, microscopic colitis was less common among subjects of Hispanic (0.34, 0.27-0.47), East Asian (0.13, 0.06-0.22), Indian (0.31, 0.10-0.73), or Middle Eastern descent (0.28, 0.07-0.74). All these ethnic subgroups were also characterized by a higher prevalence of H. pylori than the comparison group. A low prevalence of H. pylori was significantly associated with a high prevalence of microscopic colitis (R  = 0.91, p < 0.001). CONCLUSION: Ethnic variations in the gastric infection with H. pylori may be partly responsible for the observed ethnic distribution of microscopic colitis.
[Mh] Termos MeSH primário: Colite Microscópica/etnologia
Colite Microscópica/patologia
Grupos Étnicos
Infecções por Helicobacter/etnologia
Infecções por Helicobacter/patologia
Helicobacter pylori/isolamento & purificação
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Coortes
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-016-4441-6


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[PMID]:27897155
[Au] Autor:Pardi DS
[Ad] Endereço:Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
[Ti] Título:Diagnosis and Management of Microscopic Colitis.
[So] Source:Am J Gastroenterol;112(1):78-85, 2017 Jan.
[Is] ISSN:1572-0241
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microscopic colitis (MC) is a relatively common cause of chronic watery diarrhea, especially in older persons. Associated symptoms, including abdominal pain and arthralgias, are common. The diagnosis is based upon characteristic histological findings in the presence of diarrhea. The two types of MC, collagenous and lymphocytic colitis, share similar clinical features, with the main difference being the presence or absence of a thickened subepithelial collagen band. There are several treatment options for patients with MC, although only budesonide has been well studied in multiple controlled clinical trials. This review will describe the clinical features, epidemiology, pathophysiology, diagnostic criteria, and treatment of patients with MC.
[Mh] Termos MeSH primário: Colite Colagenosa/diagnóstico
Colite Linfocítica/diagnóstico
[Mh] Termos MeSH secundário: Resinas de Troca de Ânions/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Antidiarreicos/uso terapêutico
Autoimunidade/imunologia
Ácidos e Sais Biliares/metabolismo
Budesonida/uso terapêutico
Resina de Colestiramina/uso terapêutico
Colite Colagenosa/tratamento farmacológico
Colite Colagenosa/imunologia
Colite Colagenosa/patologia
Colite Linfocítica/tratamento farmacológico
Colite Linfocítica/imunologia
Colite Linfocítica/patologia
Colite Microscópica/diagnóstico
Colite Microscópica/tratamento farmacológico
Colite Microscópica/imunologia
Colite Microscópica/patologia
Colágeno/metabolismo
Colo/patologia
Predisposição Genética para Doença
Glucocorticoides/uso terapêutico
Antígenos HLA/genética
Antígenos HLA/imunologia
Seres Humanos
Mesalamina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anion Exchange Resins); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antidiarrheals); 0 (Bile Acids and Salts); 0 (Glucocorticoids); 0 (HLA Antigens); 11041-12-6 (Cholestyramine Resin); 4Q81I59GXC (Mesalamine); 51333-22-3 (Budesonide); 9007-34-5 (Collagen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1038/ajg.2016.477


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[PMID]:27796144
[Au] Autor:Hilpüsch F; Johnsen PH; Goll R; Valle PC; Sørbye SW; Abelsen B
[Ad] Endereço:a Sjøkanten legesenter and Bjarkøy legekontor , Harstad , Norway.
[Ti] Título:Microscopic colitis: a missed diagnosis among patients with moderate to severe irritable bowel syndrome.
[So] Source:Scand J Gastroenterol;52(2):173-177, 2017 Feb.
[Is] ISSN:1502-7708
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Irritable bowel syndrome (IBS) is a very common condition in general practise, affecting 10-20% of the population in the Western world. The clinical picture of diarrhoea-predominant IBS (IBS-D) resembles other chronic diarrhoeic conditions, such as microscopic colitis (MC). It is impossible to separate these by clinical examinations or lab-tests that can be done in general practise. The aim of this study was to detect any missed diagnoses when only using a symptom-based approach for the diagnosis of IBS. MATERIAL AND METHODOLOGY: We examined 87 participants diagnosed with IBS by the Rome III criteria. All the participants underwent full clinical examination, lab-tests and colonoscopy including mucosa biopsies for histological examination. RESULTS: The histological analysis revealed four cases of MC in participants who for years had been diagnosed with IBS. We found no biochemical or clinical markers that made it possible to differentiate between IBS and MC. MC was only found in the participants diagnosed with IBS-D. CONCLUSION: When long-lasting, unresolved diarrhoeic conditions are present in patients over 45-50 years of age, colonoscopy with biopsy should be performed to rule out MC and other pathologies before diagnosing IBS. In younger patients with pronounced watery diarrhoea, one should consider colonoscopy individually if there is no response to IBS-treatment.
[Mh] Termos MeSH primário: Colite Microscópica/diagnóstico
Síndrome do Intestino Irritável/diagnóstico
Síndrome do Intestino Irritável/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Biópsia
Colite Microscópica/patologia
Colonoscopia
Diagnóstico Diferencial
Diarreia/etiologia
Feminino
Medicina Geral
Seres Humanos
Masculino
Meia-Idade
Noruega
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE
[do] DOI:10.1080/00365521.2016.1242025


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[PMID]:27733667
[Au] Autor:Law EH; Badowski M; Hung YT; Weems K; Sanchez A; Lee TA
[Ad] Endereço:1 Department of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
[Ti] Título:Association Between Proton Pump Inhibitors and Microscopic Colitis.
[So] Source:Ann Pharmacother;51(3):253-263, 2017 Mar.
[Is] ISSN:1542-6270
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Microscopic colitis (MC) is a chronic inflammatory disease of the colon that is characterized by chronic, watery, nonbloody diarrhea. Concern regarding a potential association between proton-pump inhibitors (PPIs) and MC has recently emerged. We sought to systematically review and summarize the evidence for the potential association between PPIs and MC. DATA SOURCES: We systematically searched EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, International Pharmaceutical Abstracts, and Google Scholar using the terms proton-pump inhibitors (omeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, or esomeprazole), microscopic colitis, collagenous colitis, and lymphocytic colitis. STUDY SELECTION: Full-text, English-language reports of case reports/series, observational studies, experimental studies, and systematic reviews/meta-analyses published between January 2000 to August 2016 were included. Bibliographies from pertinent publications were reviewed for additional references. Outcome was defined as the development of biopsy-confirmed MC. DATA EXTRACTION/SYNTHESIS: A total of 19 publications were identified: 5 case control studies and 14 case reports/series (encompassing a total of 32 cases). All studies were limited by small sample sizes. Risk of MC by dose or specific PPI agent was not investigated in any of the studies. A review of the current body of evidence reveals a possible association between PPIs and MC. CONCLUSIONS: There is a need for large observational studies of high quality to examine the differential effect of specific PPIs and whether the magnitude of association is dose dependent. Given their widespread use, clinicians should routinely question whether patients are receiving unnecessary treatment with PPIs and discontinue therapy where appropriate.
[Mh] Termos MeSH primário: 2-Piridinilmetilsulfinilbenzimidazóis/efeitos adversos
Colite Microscópica/epidemiologia
Esomeprazol/efeitos adversos
Omeprazol/efeitos adversos
Inibidores da Bomba de Prótons/efeitos adversos
[Mh] Termos MeSH secundário: 2-Piridinilmetilsulfinilbenzimidazóis/administração & dosagem
2-Piridinilmetilsulfinilbenzimidazóis/uso terapêutico
Colite Microscópica/induzido quimicamente
Colite Microscópica/patologia
Relação Dose-Resposta a Droga
Esomeprazol/administração & dosagem
Esomeprazol/uso terapêutico
Seres Humanos
Omeprazol/administração & dosagem
Omeprazol/uso terapêutico
Guias de Prática Clínica como Assunto
Inibidores da Bomba de Prótons/administração & dosagem
Inibidores da Bomba de Prótons/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (2-Pyridinylmethylsulfinylbenzimidazoles); 0 (Proton Pump Inhibitors); D8TST4O562 (pantoprazole); KG60484QX9 (Omeprazole); N3PA6559FT (Esomeprazole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE
[do] DOI:10.1177/1060028016673859


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[PMID]:27166978
[Au] Autor:Sonnenberg A; Turner KO; Genta RM
[Ad] Endereço:Miraca Life Sciences, Irving, Texas, USA.
[Ti] Título:Differences in the socio-economic distribution of inflammatory bowel disease and microscopic colitis.
[So] Source:Colorectal Dis;19(1):38-44, 2017 Jan.
[Is] ISSN:1463-1318
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Inflammatory bowel disease (IBD) and microscopic colitis are characterized by different geographical distributions across the USA. In this cross-sectional study we utilized demographic and socio-economic information associated with individual ZIP codes to further delineate the epidemiological characteristics of the two diseases. METHOD: A total of 813 057 patients who underwent colonoscopy between 2008 and 2014 were extracted from an electronic database of histopathology reports. The prevalence of patients with IBD or microscopic colitis was expressed as percentage of the population associated with specific demographic (age, sex, ethnicity) and socio-economic characteristics (population size, housing value, annual income, tertiary education). RESULTS: Both diseases were more common among subjects from ZIP codes with predominantly White residents and less common among subjects from ZIP codes with predominantly non-White residents such as Black, Hispanic and Asian. These ethnic variations were more pronounced in microscopic colitis than IBD. Markers of affluence, such as average residential house value and annual income, were positively associated with IBD and negatively with microscopic colitis. The prevalence of both diseases was positively correlated with tertiary education. CONCLUSION: The occurrence of both IBD and microscopic colitis is influenced by environmental risk factors. The differences in the demographic, ethnic and socio-economic distributions of the two diseases suggest that different sets of risk factors affect the two diseases and that their aetiology is unrelated.
[Mh] Termos MeSH primário: Colite Microscópica/epidemiologia
Doenças Inflamatórias Intestinais/epidemiologia
Fatores Socioeconômicos
[Mh] Termos MeSH secundário: Adulto
Afroamericanos/estatística & dados numéricos
Idoso
Americanos Asiáticos/estatística & dados numéricos
Colite Microscópica/etiologia
Colonoscopia/estatística & dados numéricos
Estudos Transversais
Escolaridade
Meio Ambiente
Grupo com Ancestrais do Continente Europeu/estatística & dados numéricos
Feminino
Geografia Médica/estatística & dados numéricos
Hispano-Americanos/estatística & dados numéricos
Seres Humanos
Doenças Inflamatórias Intestinais/etiologia
Masculino
Meia-Idade
Prevalência
Fatores de Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE
[do] DOI:10.1111/codi.13378



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