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[PMID]:29324785
[Au] Autor:Joerling J; Barth SA; Schlez K; Willems H; Herbst W; Ewers C
[Ad] Endereço:Institute of Hygiene and Infectious Diseases of Animals, Justus Liebig University Giessen, Giessen, Germany.
[Ti] Título:Phylogenetic diversity, antimicrobial susceptibility and virulence gene profiles of Brachyspira hyodysenteriae isolates from pigs in Germany.
[So] Source:PLoS One;13(1):e0190928, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Swine dysentery (SD) is an economically important diarrheal disease in pigs caused by different strongly hemolytic Brachyspira (B.) species, such as B. hyodysenteriae, B. suanatina and B. hampsonii. Possible associations of epidemiologic data, such as multilocus sequence types (STs) to virulence gene profiles and antimicrobial susceptibility are rather scarce, particularly for B. hyodysenteriae isolates from Germany. In this study, B. hyodysenteriae (n = 116) isolated from diarrheic pigs between 1990 and 2016 in Germany were investigated for their STs, susceptibility to the major drugs used for treatment of SD (tiamulin and valnemulin) and genes that were previously linked with virulence and encode for hemolysins (tlyA, tlyB, tlyC, hlyA, BHWA1_RS02885, BHWA1_RS09085, BHWA1_RS04705, and BHWA1_RS02195), outer membrane proteins (OMPs) (bhlp16, bhlp17.6, bhlp29.7, bhmp39f, and bhmp39h) as well as iron acquisition factors (ftnA and bitC). Multilocus sequence typing (MLST) revealed that 79.4% of the isolates belonged to only three STs, namely ST52 (41.4%), ST8 (12.1%), and ST112 (25.9%) which have been observed in other European countries before. Another 24 isolates belonged to twelve new STs (ST113-118, ST120-123, ST131, and ST193). The temporal distribution of STs revealed the presence of new STs as well as the regular presence of ST52 over three decades (1990s-2000s). The proportion of strains that showed resistance to both tiamulin und valnemulin (39.1%) varied considerably among the most frequent STs ranging from 0% (0/14 isolates resistant) in ST8 isolates to 46.7% (14/30), 52.1% (25/48), and 85.7% (6/7) in isolates belonging to ST112, ST52, and ST114, respectively. All hemolysin genes as well as the iron-related gene ftnA and the OMP gene bhlp29.7 were regularly present in the isolates, while the OMP genes bhlp17.6 and bhmp39h could not be detected. Sequence analysis of hemolysin genes of selected isolates revealed co-evolution of tlyB, BHWA1_RS02885, BHWA1_RS09085, and BHWA1_RS02195 with the core genome and suggested independent evolution of tlyA, tlyC, and hlyA. Our data indicate that in Germany, swine dysentery might be caused by a limited number of B. hyodysenteriae clonal groups. Major STs (ST8, ST52, and ST112) are shared with other countries in Europe suggesting a possible role of the European intra-Community trade of pigs in the dissemination of certain clones. The identification of several novel STs, some of which are single or double locus variants of ST52, may on the other hand hint towards an ongoing diversification of the pathogen in the studied area. The linkage of pleuromutilin susceptibility and sequence type of an isolate might reflect a clonal expansion of the underlying resistance mechanism, namely mutations in the ribosomal RNA genes. A linkage between single virulence-associated genes (VAGs) or even VAG patterns and the phylogenetic background of the isolates could not be established, since almost all VAGs were regularly present in the isolates.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Brachyspira hyodysenteriae/efeitos dos fármacos
Brachyspira hyodysenteriae/patogenicidade
Farmacorresistência Bacteriana/genética
[Mh] Termos MeSH secundário: Animais
Proteínas de Bactérias/genética
Brachyspira hyodysenteriae/genética
Brachyspira hyodysenteriae/isolamento & purificação
Diterpenos/farmacologia
Disenteria/microbiologia
Disenteria/veterinária
Fezes/microbiologia
Alemanha
Infecções por Bactérias Gram-Negativas/microbiologia
Infecções por Bactérias Gram-Negativas/veterinária
Proteínas Hemolisinas/genética
Filogenia
Polimorfismo de Nucleotídeo Único
Proteínas Ribossômicas/genética
Sus scrofa
Suínos
Doenças dos Suínos/microbiologia
Virulência/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Diterpenes); 0 (Hemolysin Proteins); 0 (Ribosomal Proteins); 0 (ribosomal protein L3); 125-65-5 (pleuromutilin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190928


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[PMID]:28449427
[Au] Autor:Kim JB; Seo KI; Moon W
[Ad] Endereço:Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
[Ti] Título: Infection in North Korean Defector Resulted in Chronic Abdominal Pain and Growth Retardation.
[So] Source:Korean J Gastroenterol;69(4):243-247, 2017 Apr 25.
[Is] ISSN:2233-6869
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:infection is a common helminth infection, which is transmitted via soil, with worldwide distribution, especially in rural areas of developing countries. Occasionally, sporadic cases occur in non-endemic, developed areas due to the widespread of immigration. We experienced a case of Trichuris dysentery syndrome in a young North Korean defector, who had been suffering from chronic abdominal pain for 10 years. He is relatively short and thin compared with his older brother. Unexpectedly, the diagnosis, made by a colonoscopy, revealed numerous, small, white, and gently moving worms at the cecum and ascending colon. After 3 days of albendazole (400 mg once daily) administration, clinical symptoms subsided dramatically. On the follow-up colonoscopy, which was performed two months after the completion of his treatment, complete eradication was identified. Soil-transmitted helminths, including , are disappearing becoming less prevalent in South Korea as a result of both national driving force and environmental improvement. However, these diseases should be considered when we meet foreign patients from developing countries, like North Korea, presenting chronic abdominal pain. Moreover, proper treatment of North Korean defectors and performing cohort studies of them would help to prepare for the possible unification era in the field of gastroenterology.
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Tricuríase/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Animais
Ceco/parasitologia
Ceco/patologia
Colo/parasitologia
Colo/patologia
Colonoscopia
República Democrática Popular da Coreia
Disenteria/diagnóstico
Emigrantes e Imigrantes
Seres Humanos
Masculino
Óvulo/patologia
Tricuríase/complicações
Tricuríase/parasitologia
Trichuris/crescimento & desenvolvimento
Trichuris/isolamento & purificação
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180102
[Lr] Data última revisão:
180102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.4166/kjg.2017.69.4.243


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[PMID]:29064354
[Au] Autor:Jean Louis F; Buteau J; Boncy J; Anselme R; Stanislas M; Nagel MC; Juin S; Charles M; Burris R; Antoine E; Yang C; Kalou M; Vertefeuille J; Marston BJ; Lowrance DW; Deyde V
[Ad] Endereço:Centers for Disease Control and Prevention, Port-au-Prince, Haiti.
[Ti] Título:Building and Rebuilding: The National Public Health Laboratory Systems and Services Before and After the Earthquake and Cholera Epidemic, Haiti, 2009-2015.
[So] Source:Am J Trop Med Hyg;97(4_Suppl):21-27, 2017 Oct.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Before the 2010 devastating earthquake and cholera outbreak, Haiti's public health laboratory systems were weak and services were limited. There was no national laboratory strategic plan and only minimal coordination across the laboratory network. Laboratory capacity was further weakened by the destruction of over 25 laboratories and testing sites at the departmental and peripheral levels and the loss of life among the laboratory health-care workers. However, since 2010, tremendous progress has been made in building stronger laboratory infrastructure and training a qualified public health laboratory workforce across the country, allowing for decentralization of access to quality-assured services. Major achievements include development and implementation of a national laboratory strategic plan with a formalized and strengthened laboratory network; introduction of automation of testing to ensure better quality of results and diversify the menu of tests to effectively respond to outbreaks; expansion of molecular testing for tuberculosis, human immunodeficiency virus, malaria, diarrheal and respiratory diseases; establishment of laboratory-based surveillance of epidemic-prone diseases; and improvement of the overall quality of testing. Nonetheless, the progress and gains made remain fragile and require the full ownership and continuous investment from the Haitian government to sustain these successes and achievements.
[Mh] Termos MeSH primário: Cólera
Serviços de Laboratório Clínico
Desastres
Terremotos
Epidemias
Laboratórios
Saúde Pública
[Mh] Termos MeSH secundário: Cólera/epidemiologia
Disenteria/diagnóstico
Disenteria/epidemiologia
Infecções por HIV/diagnóstico
Infecções por HIV/epidemiologia
Haiti/epidemiologia
Seres Humanos
Malária/diagnóstico
Malária/epidemiologia
Técnicas de Diagnóstico Molecular
Tuberculose/diagnóstico
Tuberculose/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171025
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0941


  4 / 1406 MEDLINE  
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[PMID]:28922822
[Au] Autor:Richards J
[Ad] Endereço:Vaden Health Center, Stanford University.
[Ti] Título:Comment on 'Guidelines for the prevention of and treatment of travelers' diarrhea: a graded expert panel report by Riddle et al.'
[So] Source:J Travel Med;24(6), 2017 09 01.
[Is] ISSN:1708-8305
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Diarreia/prevenção & controle
Viagem
[Mh] Termos MeSH secundário: Disenteria
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE
[do] DOI:10.1093/jtm/tax054


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[PMID]:28719282
[Au] Autor:Stoney RJ; Han PV; Barnett ED; Wilson ME; Jentes ES; Benoit CM; MacLeod WB; Hamer DH; Chen LH
[Ad] Endereço:Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia.
[Ti] Título:Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers.
[So] Source:Am J Trop Med Hyg;96(6):1388-1393, 2017 Jun.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AbstractThis prospective cohort study describes travelers' diarrhea (TD) and non-TD gastrointestinal (GI) symptoms among international travelers from the Boston area, the association of TD with traveler characteristics and dietary practices, use of prescribed antidiarrheal medications, and the impact of TD and non-TD GI symptoms on planned activities during and after travel. We included adults who received a pre-travel consultation at three Boston-area travel clinics and who completed a three-part survey: pre-travel, during travel, and post-travel (2-4 weeks after return). TD was defined as self-reported diarrhea with or without nausea/vomiting, abdominal pain, or fever. Demographic and travel characteristics were evaluated by χ test for categorical and Wilcoxon rank-sum test for continuous variables. Analysis of dietary practices used logistic generalized estimating equation models or logistic regression models. Of 628 travelers, 208 (33%) experienced TD and 45 (7%) experienced non-TD GI symptoms. Of 208 with TD, 128 (64%), 71 (36%), and 123 (62%) were prescribed ciprofloxacin, azithromycin, and/or loperamide before travel, respectively. Thirty-nine (36%) of 108 took ciprofloxacin, 20 (38%) of 55 took azithromycin, and 28 (28%) of 99 took loperamide during travel. Of 172 with TD during travel, 24% stopped planned activities, and 2% were hospitalized. Of 31 with non-TD GI symptoms during travel, six (13%) stopped planned activities. International travelers continue to experience diarrhea and other GI symptoms, resulting in disruption of planned activities and healthcare visits for some. Although these illnesses resulted in interruption of travel plans, a relatively small proportion took prescribed antibiotics.
[Mh] Termos MeSH primário: Diarreia/epidemiologia
Disenteria/epidemiologia
Gastroenteropatias/epidemiologia
Viagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Antibacterianos/uso terapêutico
Antidiarreicos/uso terapêutico
Azitromicina/uso terapêutico
Boston/epidemiologia
Ciprofloxacino/uso terapêutico
Diarreia/tratamento farmacológico
Disenteria/tratamento farmacológico
Feminino
Gastroenteropatias/tratamento farmacológico
Seres Humanos
Loperamida/uso terapêutico
Masculino
Meia-Idade
Estudos Prospectivos
Autorrelato
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antidiarrheals); 5E8K9I0O4U (Ciprofloxacin); 6X9OC3H4II (Loperamide); 83905-01-5 (Azithromycin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0447


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[PMID]:28653489
[Au] Autor:Berendes D; Leon J; Kirby A; Clennon J; Raj S; Yakubu H; Robb K; Kartikeyan A; Hemavathy P; Gunasekaran A; Roy S; Ghale BC; Kumar JS; Mohan VR; Kang G; Moe C
[Ad] Endereço:School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
[Ti] Título:Household sanitation is associated with lower risk of bacterial and protozoal enteric infections, but not viral infections and diarrhoea, in a cohort study in a low-income urban neighbourhood in Vellore, India.
[So] Source:Trop Med Int Health;22(9):1119-1129, 2017 Sep.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This study examined associations between household sanitation and enteric infection - including diarrhoeal-specific outcomes - in children 0-2 years of age in a low-income, dense urban neighbourhood. METHODS: As part of the MAL-ED study, 230 children in a low-income, urban, Indian neighbourhood provided stool specimens at 14-17 scheduled time points and during diarrhoeal episodes in the first 2 years of life that were analysed for bacterial, parasitic (protozoa and helminths) and viral pathogens. From interviews with caregivers in 100 households, the relationship between the presence (and discharge) of household sanitation facilities and any, pathogen-specific, and diarrhoea-specific enteric infection was tested through mixed-effects Poisson regression models. RESULTS: Few study households (33%) reported having toilets, most of which (82%) discharged into open drains. Controlling for season and household socio-economic status, the presence of a household toilet was associated with lower risks of enteric infection (RR: 0.91, 95% CI: 0.79-1.06), bacterial infection (RR: 0.87, 95% CI: 0.75-1.02) and protozoal infection (RR: 0.64, 95% CI: 0.39-1.04), although not statistically significant, but had no association with diarrhoea (RR: 1.00, 95% CI: 0.68-1.45) or viral infections (RR: 1.12, 95% CI: 0.79-1.60). Models also suggested that the relationship between household toilets discharging to drains and enteric infection risk may vary by season. CONCLUSIONS: The presence of a household toilet was associated with lower risk of bacterial and protozoal enteric infections, but not diarrhoea or viral infections, suggesting the health effects of sanitation may be more accurately estimated using outcome measures that account for aetiologic agents.
[Mh] Termos MeSH primário: Infecções Bacterianas/prevenção & controle
Diarreia
Enteropatias/prevenção & controle
Pobreza
Infecções por Protozoários/prevenção & controle
Sanitários Públicos
Viroses
[Mh] Termos MeSH secundário: Adulto
Animais
Infecções Bacterianas/etiologia
Infecções Bacterianas/microbiologia
Pré-Escolar
Estudos de Coortes
Diarreia/etiologia
Disenteria/etiologia
Disenteria/prevenção & controle
Fezes
Helmintíase/etiologia
Helmintíase/prevenção & controle
Helmintos
Seres Humanos
Renda
Índia
Lactente
Recém-Nascido
Enteropatias/etiologia
Enteropatias/microbiologia
Enteropatias/parasitologia
Infecções por Protozoários/etiologia
Infecções por Protozoários/parasitologia
Distribuição Espacial da População
Fatores de Risco
Saneamento
População Urbana
Viroses/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12915


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[PMID]:28647986
[Au] Autor:Yu F; Wang RN; Chen X; Zheng SF; Wang YY; Chen Y
[Ad] Endereço:Key Laboratory of Clinical in Vitro Diagnostic Techniques of Zhejiang Province, Department of Clinical Laboratory, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
[Ti] Título:[Studies on the serum types and identification efficiency on Diarrheagenic isolated from diarrhea patients, in Zhejiang province].
[So] Source:Zhonghua Liu Xing Bing Xue Za Zhi;38(6):800-804, 2017 Jun 10.
[Is] ISSN:0254-6450
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the serotypes of Diarrheagenic (DEC) isolated from diarrheal patients in Zhejiang province and to explore the identification efficiency of serological screening methods. Serological agglutination tests were carried out in 696 strains of DEC (through the identification of virulence genes) which were selected from the Infectious Diarrhea Pathogen Monitoring Network Strain Bank of Zhejiang province, from July 2009 to June 2013. Results of virulence genes, serological identification and classification were compared. Among the 696 isolates of DEC, O antigen type was identified in 288 (41.4 ) isolates which belonging to 35 different 'O' serum types. H antigen was seen in 171 (24.6 ) isolates and determined as having 21 types. The agglutination rates of EAEC, ETEC, EPEC and EHEC isolates were 31.9 (130/408), 70.6 (127/180), 31.5 (29/92) and 14.3 (2/14), respectively and belonged to 30, 18, 15 kinds of 'O' sero-groups, respectively. One EHEC isolate was identified as O157∶H7. Serum groups were diverse for EAEC and EPEC, while relatively concentrated on ETEC. Different types of DEC might belong to the same sero-group or type. Among the 74 strains of DEC available for classification serologically, 41 isolates were in consistent with virulence gene identification and another 33 strains were not. The sero-group/type of DEC strains in Zhejiang were varied. Based on the serological screening method alone, DEC classification might end in getting the wrong answer, thus we would recommend the use of virulence gene for the purpose of identification.
[Mh] Termos MeSH primário: Diarreia/microbiologia
Infecções por Escherichia coli/diagnóstico
Escherichia coli/classificação
Escherichia coli/genética
Reação em Cadeia da Polimerase Multiplex/métodos
Antígenos O/análise
[Mh] Termos MeSH secundário: Testes de Aglutinação
Disenteria/microbiologia
Escherichia coli/isolamento & purificação
Infecções por Escherichia coli/microbiologia
Genes Bacterianos
Seres Humanos
Sensibilidade e Especificidade
Sorotipagem
Virulência
Fatores de Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (O Antigens); 0 (Virulence Factors)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0254-6450.2017.06.022


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[PMID]:28595500
[Au] Autor:He X; Luan F; Zhao Z; Ning N; Li M; Jin L; Chang Y; Zhang Q; Wu N; Huang L
[Ad] Endereço:* Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710054, P. R. China.
[Ti] Título:The Genus Patrinia: A Review of Traditional Uses, Phytochemical and Pharmacological Studies.
[So] Source:Am J Chin Med;45(4):637-666, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:The aim of the present review is to comprehensively outline the botanical description, traditional uses, phytochemistry, pharmacology and toxicology of Patrinia, and to discuss possible trends for the further study of medicinal plants from the genus Patrinia. The genus Patrinia plays an important role in Asian medicine for the treatment of erysipelas, conjunctival congestion with swelling and pain, peri-appendicular abscesses, lung carbuncle, dysentery, leucorrhea, and postpartum disease. More than 210 chemical constituents have been isolated and identified from Patrinia plants, especially P. scabiosaefolia Fisch., P. scabra Bunge, P. villosa Juss., P. heterophylla Bunge and P. rupestris(Pall.) Juss[Formula: see text] Of these compounds, triterpenoids and saponins, iridoids, flavonoids, and lignans are the major or active constituents. Both in vitro and in vivo studies have indicated that some monomer compounds and crude extracts from the genus Patrinia possess wide pharmacological activities, including antitumor, anti-inflammatory, antibacterial, and antiviral effects. In addition, they have been shown to have valuable and positive effects on the immune and nervous system in experimental animals. There are also some reports on the clinical uses and toxicity of these species. However, few reports have been published concerning the material identification or quality control of Patrinia species, and the clinical uses and toxic effects of these plants are relatively sparse. More attention must be given to these issues.
[Mh] Termos MeSH primário: Anti-Inflamatórios
Antineoplásicos Fitogênicos
Patrinia/química
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Abscesso/tratamento farmacológico
Animais
Antibacterianos
Antivirais
Disenteria/tratamento farmacológico
Erisipela/tratamento farmacológico
Flavonoides/isolamento & purificação
Seres Humanos
Iridoides/isolamento & purificação
Lignanas/isolamento & purificação
Patrinia/toxicidade
Extratos Vegetais/uso terapêutico
Extratos Vegetais/toxicidade
Saponinas/isolamento & purificação
Triterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antiviral Agents); 0 (Flavonoids); 0 (Iridoids); 0 (Lignans); 0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500379


  9 / 1406 MEDLINE  
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[PMID]:28387879
[Au] Autor:Beuttemmuller EA; Alfieri AF; Headley SA; Alfieri AA
[Ad] Endereço:Laboratório Multiusuário em Saúde Animal, Unidade de Biologia Molecular, Departamento de Medicina Veterinária Preventiva, Universidade Estadual de Londrina, Londrina, PR, Brasil.
[Ti] Título:Brazilian strain of bovine respiratory coronavirus is derived from dual enteric and respiratory tropism.
[So] Source:Genet Mol Res;16(2), 2017 Apr 05.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Bovine coronavirus (BCoV) is a pathogen related to enteric and respiratory diseases in cattle worldwide. Enteric (BECoV) strains of BCoV are predominant in South America, and genetic investigations have been conducted to identify its relationship with isolates of respiratory origin (BRCoV). In this study, we used a BRCoV strain (BR-UEL11) derived from an outbreak of respiratory disease in feedlot cattle in southern Brazil, and compared the partial sequence of the polymorphic region of Spike (which was detected and sequenced by two distinct reverse transcription-polymerase chain reactions) with those of other BCoV strains. The phylogenetic relationship of BR-UEL11 with Brazilian BCoV, which is associated with calf diarrhea and winter dysentery (enteric, BECoV; respiratory, BRCoV), and classical reference prototypes was analyzed. The analysis showed that the BRCoV strains from Brazil clustered with a clade that was distinct from most isolates associated with calf diarrhea (BECoV) and ancestral prototype strains such as Mebus, Nebraska, and LYVB. Furthermore, the BRCoV strains from Brazil clustered with a clade that contained recent strains associated with winter dysentery, showing 98-99% nucleotide identity with those strains. These results suggested that the Brazilian BCoV evolved from being solely enteric to a dual enteric and respiratory tropic virus.
[Mh] Termos MeSH primário: Coronavirus Bovino/fisiologia
[Mh] Termos MeSH secundário: Animais
Brasil
Bovinos
Doenças dos Bovinos/virologia
Infecções por Coronavirus/veterinária
Infecções por Coronavirus/virologia
Coronavirus Bovino/genética
Disenteria/veterinária
Disenteria/virologia
Evolução Molecular
Fezes/virologia
Glicoproteínas de Membrana/genética
Filogenia
Análise de Sequência de DNA
Proteínas do Envelope Viral/genética
Tropismo Viral/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Glycoproteins); 0 (Viral Envelope Proteins)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16029580


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[PMID]:28301166
[Au] Autor:Venkatakrishnan V; Quintana-Hayashi MP; Mahu M; Haesebrouck F; Pasmans F; Lindén SK
[Ad] Endereço:Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg 405 30, Sweden.
[Ti] Título:Brachyspira hyodysenteriae Infection Regulates Mucin Glycosylation Synthesis Inducing an Increased Expression of Core-2 O-Glycans in Porcine Colon.
[So] Source:J Proteome Res;16(4):1728-1742, 2017 Apr 07.
[Is] ISSN:1535-3907
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Brachyspira hyodysenteriae causes swine dysentery (SD), leading to global financial losses to the pig industry. Infection with this pathogen results in an increase in B. hyodysenteriae binding sites on mucins, along with increased colonic mucin secretion. We predict that B. hyodysenteriae modifies the glycosylation pattern of the porcine intestinal mucus layer to optimize its host niche. We characterized the swine colonic mucin O-glycome and identified the differences in glycosylation between B. hyodysenteriae-infected and noninfected pigs. O-Glycans were chemically released from soluble and insoluble mucins isolated from five infected and five healthy colon tissues and analyzed using porous graphitized carbon liquid chromatography tandem mass spectrometry. In total, 94 O-glycans were identified, with healthy pigs having higher interindividual variation, although a larger array of glycan structures was present in infected pigs. This implied that infection induced loss of individual variation and that specific infection-related glycans were induced. The dominating structures shifted from core-4-type O-glycans in noninfected pigs toward core-2-type O-glycans in infected animals, which correlated with increased levels of the C2GnT glycosyl transferase. Overall, glycan chains from infected pigs were shorter and had a higher abundance of structures that were neutral or predominantly contained NeuGc instead of NeuAc, whereas they had a lower abundance of structures that were fucosylated, acidic, or sulfated than those from noninfected pigs. Therefore, we conclude that B. hyodysenteriae plays a major role in regulating colonic mucin glycosylation in pigs during SD. The changes in mucin O-glycosylation thus resulted in a glycan fingerprint in porcine colonic mucus that may provide increased exposure of epitopes important for host-pathogen interactions. The results from this study provide potential therapeutic targets and a platform for investigations of B. hyodysenteriae interactions with the host via mucin glycans.
[Mh] Termos MeSH primário: Brachyspira hyodysenteriae/genética
Disenteria/microbiologia
Mucinas/metabolismo
Polissacarídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Brachyspira hyodysenteriae/patogenicidade
Colo/metabolismo
Colo/patologia
Disenteria/patologia
Disenteria/veterinária
Glicosilação
Interações Hospedeiro-Patógeno/genética
Mucinas/química
Polissacarídeos/química
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mucins); 0 (Polysaccharides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jproteome.7b00002



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