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[PMID]:28652148
[Au] Autor:Sullivan KJ; Wei M; Chernetsova E; Hallani S; de Nanassy J; Benchimol EI; Mack DR; Nasr A; El Demellawy D
[Ad] Endereço:Department of Pathology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada K1H 8L1. Electronic address: ksullivan@cheo.on.ca.
[Ti] Título:Value of upper endoscopic biopsies in predicting medical refractoriness in pediatric patients with ulcerative colitis.
[So] Source:Hum Pathol;66:167-176, 2017 Aug.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Refractory ulcerative colitis (UC) occurs in patients who experience a severe disease manifestation that is unresponsive to medical therapy. The assessment of upper endoscopic microscopic findings and its correlation with refractory UC has not been fully studied in pediatric patients and is the focus of this study. Medical records of UC patients treated at a tertiary pediatric center between 2000 and 2014 were reviewed. Endoscopic biopsies of the upper gastrointestinal (GI) tract of patients meeting a priori inclusion criteria were compared between refractory UC patients and nonrefractory UC patients for active inflammation. Statistically significant differences were determined between groups, and tissues shown to have significant differences were further evaluated for their diagnostic performance. A total of 52 patients were included, 26 in each group. Significant differences were observed in intraepithelial neutrophil infiltration and percentage involvement of crypts/glands for the antrum, body, and duodenal bulb (P ≤ .001, .005, and .01 [intraepithelial neutrophil infiltration] and P = .001, .009, and .015 [% involvement], respectively). Microabscesses of mucosal glands/crypts were also experienced in a greater number of refractory UC patients in the stomach (ie, antrum and/or body of stomach; P = .005) and duodenum (ie, duodenum and/or duodenal bulb; P = .023). The sensitivity and specificity of upper GI tissues to predict refractory UC were moderate, with sensitivities ranging from 38% to 67% and specificities ranging from 81% to 100%. Our results suggest that children with refractory UC are more likely to have active inflammation in the upper GI tract, and thus, this may represent a predictor of responsiveness to current medical therapy.
[Mh] Termos MeSH primário: Colite Ulcerativa/patologia
Duodenite/patologia
Duodeno/patologia
Endoscopia do Sistema Digestório
Gastrite/patologia
Estômago/patologia
[Mh] Termos MeSH secundário: Adolescente
Anti-Inflamatórios/uso terapêutico
Biópsia
Criança
Colectomia
Colite Ulcerativa/terapia
Resistência a Medicamentos
Esôfago/patologia
Feminino
Fármacos Gastrointestinais/uso terapêutico
Seres Humanos
Masculino
Infiltração de Neutrófilos
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Centros de Atenção Terciária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Gastrointestinal Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28282232
[Au] Autor:Ayala I; Bernal LJ; Garcia-Martinez JD; Gomez MA; Navarro JA; Bernabe A
[Ad] Endereço:From the Animal Medicine and Surgery Department (I.A., L.J.B., J.D.G.-M.); and Veterinary Pathology Department (M.A.G., J.A.N., A.B.), University of Murcia, Murcia, Spain.
[Ti] Título:An Atypical Case of Leishmaniasis Associated with Chronic Duodenitis in a Dog.
[So] Source:J Am Anim Hosp Assoc;53(2):101-106, 2017 Mar/Apr.
[Is] ISSN:0587-2871
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We describe an atypical case of duodenal leishmaniasis in a boxer dog presenting with chronic diarrhea and poor general condition. Antidiarrheic therapy was previously administered without success and inflammatory bowel disease localized to the small intestine was suspected, given the chronic clinical signs and by ruling out other known causes of gastrointestinal inflammation. Endoscopic biopsy of duodenum showed a moderate increase in lamina propria lymphocytes, plasma cells, and macrophages. Basophilic bodies were seen in the cytoplasm of numerous macrophages, suggestive of Leishmania spp, confirmed by immunostaining, and a diagnosis of granulomatous duodenitis associated to Leishmania infection was made. After 7 mo of therapy, a significant clinical improvement and weight gain were observed, and endoscopic histology showed no evidence of Leishmania. A progressive decline of anti-leishmanial antibody titer was also observed during follow-up. This report emphasizes the importance of atypical symptoms and the unusual location of visceral leishmaniasis, suggesting the need to consider leishmaniasis in the differential diagnosis of canine chronic enteritis, especially in endemic areas.
[Mh] Termos MeSH primário: Doenças do Cão/parasitologia
Duodenite/veterinária
Leishmaniose/veterinária
[Mh] Termos MeSH secundário: Alopurinol/administração & dosagem
Alopurinol/uso terapêutico
Animais
Doenças do Cão/tratamento farmacológico
Doenças do Cão/etiologia
Cães
Quimioterapia Combinada
Duodenite/complicações
Duodenite/tratamento farmacológico
Duodenite/parasitologia
Leishmaniose/complicações
Leishmaniose/tratamento farmacológico
Masculino
Meglumina/administração & dosagem
Meglumina/uso terapêutico
Compostos Organometálicos/administração & dosagem
Compostos Organometálicos/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 63CZ7GJN5I (Allopurinol); 6HG8UB2MUY (Meglumine); 75G4TW236W (meglumine antimoniate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.5326/JAAHA-MS-6401


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[PMID]:27834292
[Au] Autor:Besecker EM; Deiter GM; Pironi N; Cooper TK; Holmes GM
[Ad] Endereço:Department of Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, Pennsylvania.
[Ti] Título:Mesenteric vascular dysregulation and intestinal inflammation accompanies experimental spinal cord injury.
[So] Source:Am J Physiol Regul Integr Comp Physiol;312(1):R146-R156, 2017 Jan 01.
[Is] ISSN:1522-1490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial hypotension. Gastrointestinal (GI) tissues are critically dependent upon adequate blood flow and even brief periods of visceral hypoxia triggers GI dysmotility. The aim of this study was to test the hypothesis that T3-SCI induces visceral hypoperfusion, diminished postprandial vascular reflexes, and concomitant visceral inflammation. We measured in vivo systemic arterial blood pressure and superior mesenteric artery (SMA) and duodenal blood flow in anesthetized T3-SCI rats at 3 days and 3 wk postinjury either fasted or following enteral feeding of a liquid mixed-nutrient meal (Ensure). In separate cohorts of fasted T3-SCI rats, markers of intestinal inflammation were assayed by qRT-PCR. Our results show that T3-SCI rats displayed significantly reduced SMA blood flow under all experimental conditions (P < 0.05). Specifically, the anticipated elevation of SMA blood flow in response to duodenal nutrient infusion (postprandial hyperemia) was either delayed or absent after T3-SCI. The dysregulated SMA blood flow in acutely injured T3-SCI rats coincides with abnormal intestinal morphology and elevation of inflammatory markers, all of which resolve after 3 wk. Specifically, Icam1, Ccl2 (MCP-1), and Ccl3 (MIP-1α) were acutely elevated following T3-SCI. Our data suggest that arterial hypotension diminishes mesenteric blood flow necessary to meet mucosal demands at rest and during digestion. The resulting GI ischemia and low-grade inflammation may be an underlying pathology leading to GI dysfunction seen following acute T3-SCI.
[Mh] Termos MeSH primário: Citocinas/imunologia
Duodenite/etiologia
Duodenite/fisiopatologia
Artéria Mesentérica Superior/fisiopatologia
Traumatismos da Medula Espinal/complicações
Traumatismos da Medula Espinal/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Intestino Delgado
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161112
[St] Status:MEDLINE
[do] DOI:10.1152/ajpregu.00347.2016


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[PMID]:27759774
[Au] Autor:Ribeiro IC; Kubrusly LF; Nassif PA; Ribeiro PF; Veras RO; Neppel A
[Ad] Endereço:Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute, Curitiba, PR, Brazil.
[Ti] Título:RELATIONSHIP BETWEEN THE PRESENCE OF HELICOBACTER PYLORI WITH INFLAMMATORY ENDOSCOPIC CHANGES IN GASTRODUODENAL MUCOSA.
[So] Source:Arq Bras Cir Dig;29(3):142-145, 2016 Jul-Sep.
[Is] ISSN:2317-6326
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:Background:: The influence of Helicobacter pylori (HP) in inflammatory disorders of the digestive mucosa has been the subject of several studies since socioeconomic, personal and environmental factors were implicated in the bacteria transmission. Aim:: To correlate the inflammatory endoscopic findings with HP infection and the onset of mucosal diseases mucous of the upper digestive tract. Method:: Comparative observational study, in which were collected data from 2247 patients who underwent upper endoscopy and biopsies for HP with urease test. The patients were divided into two groups: HP+ and HP- (control) in which endoscopic findings were observed for the following changes: esophagitis, esophageal ulcer, gastritis, erosive gastritis, gastric ulcer, bulboduodenitis, bulbar ulcer and without disease. Results:: As for esophagitis, there was little disparity in the distribution favorable to HP+ group (HP+ =67.11% and HP- =69.89%) and esophageal ulcer (HP+ =0% and HP- =0, 21%). Gastritis was favorable to HP- group (HP+ =78.34% and HP- =73.63%), as well as erosive gastritis (HP+ = 67,11% and HP- = 64,55%), in bulboduodenitis (HP+ =1,87% and HP- 1,23%), in gastric ulcer (HP+ =2,14% and HP- =2,03%) and in the absence of alterations in the HP+ group (4.81%) with the HP- control group (6,30%), in which there was little disproportion in favor of HP- group, but without statistical significance. As for the bulbar ulcer (HP +=10.16% and HP- =4.48%), there was statistically significant (p=0.00001). Conclusion:: There is no difference between HP+ and HP- groups in inflammatory changes in endoscopic gastroduodenal mucosa, except for the relationship between HP and bulbar ulcer. Racional: : A influência do Helicobacter pylori (HP) nas alterações inflamatórias das mucosas digestivas tem sido objeto de vários estudos uma vez que fatores socioeconômicos, pessoais e ambientais são implicados na transmissão da bactéria, facilitando-a. Objetivo: : Relacionar os achados inflamatórios endoscópicos com a infecção pelo HP e o aparecimento de doenças mucosas do trato digestivo alto. Método: : Estudo observacional comparativo, o qual foram coletados dados de 2247 pacientes submetidos à endoscopia digestiva alta e biópsias para HP com teste de urease. Os pacientes foram divididos em dois grupos: HP+ e o controle HP-dentro dos quais foram observados os achados endoscópicos referentes às seguintes alterações: esofagite, úlcera esofágica, gastrite, gastrite erosiva, úlcera gástrica, bulboduodenite, úlcera bulbar e sem doença. Resultados: : Quanto à esofagite, observou-se pequena desproporção na distribuição, favorável ao grupo HP+ (HP+ =67,11% e HP- =69,89%) bem como na úlcera esofágica (HP+ =0% e HP- =0,21%). Na gastrite foi favorável ao grupo HP- (HP+ =78.34% e HP- =73.63%), assim como na gastrite erosiva (HP+ = 67,11% e HP- = 64,55%), na bulboduodenite (HP+ = 1,87% e HP- 1,23%), na úlcera gástrica (HP+ =2,14% e HP- =2,03%) e na ausência de alterações no grupo HP+ (4.81%) com o grupo controle HP- (6,30%), nos quais há pequena desproporção favorável ao grupo HP-, porém, sem significância estatística. Já quanto à úlcera bulbar (HP+ =10,16% e HP- =4,48%), houve significância estatística (p=0,00001). Conclusão: : Não há diferenciação entre os grupos HP+ e HP- nas alterações endoscópicas inflamatórias na mucosa gastroduodenal, exceto para a relação entre HP e úlcera bulbar.
[Mh] Termos MeSH primário: Duodenite/microbiologia
Duodenite/patologia
Duodenoscopia
Esofagite/microbiologia
Esofagite/patologia
Mucosa Gástrica/microbiologia
Mucosa Gástrica/patologia
Gastrite/microbiologia
Gastrite/patologia
Gastroscopia
Helicobacter pylori/isolamento & purificação
Mucosa Intestinal/microbiologia
Mucosa Intestinal/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


  5 / 1411 MEDLINE  
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[PMID]:27729741
[Au] Autor:Islek A; Yilmaz A; Elpek GO; Erin N
[Ad] Endereço:Ali Islek, Aygen Yilmaz, Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya 07070, Turkey.
[Ti] Título:Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators.
[So] Source:World J Gastroenterol;22(37):8349-8360, 2016 Oct 07.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: To investigate the roles of the neuropeptides vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP) in chronic gastritis and duodenitis in children. METHODS: Biopsy samples from the gastric and duodenal mucosa of 52 patients and 30 control subjects were obtained. Samples were taken for pathological examination, immunohistochemical staining, enzyme activity measurements and quantitative measurements of tissue peptide levels. RESULTS: We observed differential effects of the disease on peptide levels, which were somewhat different from previously reported changes in chronic gastritis in adults. Specifically, SP was increased and CGRP and VIP were decreased in patients with gastritis. The changes were more prominent at sites where gastritis was severe, but significant changes were also observed in neighboring areas where gastritis was less severe. Furthermore, the degree of changes was correlated with the pathological grade of the disease. The expression of CD10, the enzyme primarily involved in SP hydrolysis, was also decreased in patients with duodenitis. CONCLUSION: Based on these findings, we propose that decreased levels of VIP and CGRP and increased levels of SP contribute to pathological changes in gastric mucosa. Hence, new treatments targeting these molecules may have therapeutic and preventive effects.
[Mh] Termos MeSH primário: Duodenite/metabolismo
Mucosa Gástrica/metabolismo
Gastrite/metabolismo
Neuropeptídeos/metabolismo
[Mh] Termos MeSH secundário: Dor Abdominal
Adolescente
Peptídeo Relacionado com Gene de Calcitonina/metabolismo
Estudos de Casos e Controles
Criança
Endoscopia
Feminino
Seres Humanos
Hidrólise
Imuno-Histoquímica
Masculino
Neprilisina/metabolismo
Substância P/metabolismo
Peptídeo Intestinal Vasoativo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuropeptides); 33507-63-0 (Substance P); 37221-79-7 (Vasoactive Intestinal Peptide); 83652-28-2 (Calcitonin Gene-Related Peptide); EC 3.4.24.11 (Neprilysin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


  6 / 1411 MEDLINE  
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[PMID]:27694084
[Au] Autor:Andoulo FA; Kowo M; Ngatcha G; Ndam AN; Awouoyiegnigni B; Sida MB; Tzeuton C; Ndjitoyap Ndam EC
[Ad] Endereço:Centre hospitalier universitaire de Yaoundé, faculté de médecine et des sciences biomédicales, université de Yaoundé I, 7132 Yaoundé, Cameroon.
[Ti] Título:Prevalence of Helicobacter pylori prevalence and upper gastrointestinal endoscopy in HIV/AIDS patients with gastrointestinal symptoms in the University Teaching Hospitals in Cameroon.
[Ti] Título:Prévalence de l'infection à Helicobacter pylori au travers de l'endoscopie digestive haute chez les patients VIH/sida avec des symptômes gastro-intestinaux dans les hôpitaux universitaires au Cameroun..
[So] Source:Med Sante Trop;26(3):278-282, 2016 Aug 01.
[Is] ISSN:2261-2211
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the prevalence of Helicobacter pylori (H. pylori) infection and of various upper gastrointestinal (GI) lesions in HIV patients with GI symptoms and the relation of H. pylori infection to CD4 cell counts. MATERIAL AND METHODS: In all, 56 HIV patients and 56 age- and sex-matched HIV controls, all with upper GI symptoms, were evaluated by an upper endoscopy examination and gastric biopsy. H. pylori status was assessed with a urease test and histology. HIV was diagnosed with the rapid test and enzyme-linked immunosorbent assay (ELISA). RESULTS: The prevalence of H. pylori was 50% (28/56 [95%CI 36.3-63.7]) in HIV subjects and 55% (31/56 [95%CI 41.5-68.7]) in HIV controls (p = 0.57). H. pylori infection rates did not differ significantly in HIV patients between those with a CD4 count ≥200/mm (52%) and those with a CD4 count <200/mm (42%) (p = 0.62). The prevalence on endoscopy of specific lesions in HIV patients and controls were compared: esophageal candidiasis (61%, 34/56 vs. 7%; p<0.0001), esophageal ulcers (18%, 10/56 vs 2%; p = 0.01), corpus gastritis (41%; 23/56 vs 5%; p<0.0001), and duodenitis (20%, 11/56, vs 0%; p = 0.001). CONCLUSIONS: The prevalence rate of H. pylori did not differ significantly between HIV and HIV subjects. Prevalence of H. pylori was also lower, although not significantly, among HIV patients with CD4 T-cell counts below 200/mm . On endoscopy, esophageal candidiasis was the most common finding in HIV patients, discovered by dysphagia.
[Mh] Termos MeSH primário: Endoscopia Gastrointestinal
Infecções por HIV/epidemiologia
Infecções por Helicobacter/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Contagem de Linfócito CD4
Camarões/epidemiologia
Candidíase/diagnóstico
Estudos de Casos e Controles
Duodenite/diagnóstico
Doenças do Esôfago/diagnóstico
Doenças do Esôfago/microbiologia
Feminino
Gastrite/diagnóstico
Infecções por Helicobacter/diagnóstico
Helicobacter pylori
Hospitais de Ensino
Hospitais Universitários
Seres Humanos
Masculino
Meia-Idade
Prevalência
Estudos Prospectivos
Úlcera/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


  7 / 1411 MEDLINE  
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[PMID]:27229122
[Au] Autor:Gao N; Bergstrom K; Fu J; Xie B; Chen W; Xia L
[Ad] Endereço:The Department of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma;
[Ti] Título:Loss of intestinal O-glycans promotes spontaneous duodenal tumors.
[So] Source:Am J Physiol Gastrointest Liver Physiol;311(1):G74-83, 2016 Jul 01.
[Is] ISSN:1522-1547
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mucin-type O-glycans, primarily core 1- and core 3-derived O-glycans, are the major mucus barrier components throughout the gastrointestinal tract. Previous reports identified the biological role of O-glycans in the stomach and colon. However, the biological function of O-glycans in the small intestine remains unknown. Using mice lacking intestinal core 1- and core 3-derived O-glycans [intestinal epithelial cell C1galt1(-/-);C3GnT(-/-) or double knockout (DKO)], we found that loss of O-glycans predisposes DKO mice to spontaneous duodenal tumorigenesis by ∼1 yr of age. Tumor incidence did not increase with age; however, tumors advanced in aggressiveness by 20 mo. O-glycan deficiency was associated with reduced luminal mucus in DKO mice before tumor development. Altered intestinal epithelial homeostasis with enhanced baseline crypt proliferation characterizes these phenotypes as assayed by Ki67 staining. In addition, fluorescence in situ hybridization analysis reveals a significantly lower bacterial burden in the duodenum compared with the large intestine. This phenotype is not reduced with antibiotic treatment, implying O-glycosylation defects, rather than bacterial-induced inflammation, which causes spontaneous duodenal tumorigenesis. Moreover, inflammatory responses in DKO duodenal mucosa are mild as assayed with histology, quantitative PCR for inflammation-associated cytokines, and immunostaining for immune cells. Importantly, inducible deletion of intestinal O-glycans in adult mice leads to analogous spontaneous duodenal tumors, although with higher incidence and heightened severity compared with mice with O-glycans constitutive deletion. In conclusion, these studies reveal O-glycans within the small intestine are critical determinants of duodenal cancer risk. Future studies will provide insights into the pathogenesis in the general population and those at risk for this rare but deadly cancer.
[Mh] Termos MeSH primário: Adenocarcinoma/metabolismo
Transformação Celular Neoplásica/metabolismo
Neoplasias Duodenais/metabolismo
Duodeno/metabolismo
Muco/metabolismo
[Mh] Termos MeSH secundário: Adenocarcinoma/genética
Adenocarcinoma/patologia
Animais
Linhagem Celular
Proliferação Celular
Transformação Celular Neoplásica/genética
Transformação Celular Neoplásica/patologia
Neoplasias Duodenais/genética
Neoplasias Duodenais/patologia
Duodenite/metabolismo
Duodenite/patologia
Duodeno/patologia
Galactosiltransferases/deficiência
Galactosiltransferases/genética
Predisposição Genética para Doença
Glicosilação
Camundongos da Linhagem 129
Camundongos Endogâmicos C57BL
Camundongos Knockout
N-Acetilglucosaminiltransferases/deficiência
N-Acetilglucosaminiltransferases/genética
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.4.1.- (C1galt1 protein, mouse); EC 2.4.1.- (Galactosyltransferases); EC 2.4.1.- (N-Acetylglucosaminyltransferases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE
[do] DOI:10.1152/ajpgi.00060.2016


  8 / 1411 MEDLINE  
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[PMID]:27129486
[Au] Autor:Cheung D; Menon S; Hoare J; Dhar A; Trudgill N
[Ad] Endereço:Sandwell General Hospital, Lyndon, West Bromwich, UK.
[Ti] Título:Factors Associated with Upper Gastrointestinal Cancer Occurrence After Endoscopy that Did Not Diagnose Cancer.
[So] Source:Dig Dis Sci;61(9):2674-84, 2016 Sep.
[Is] ISSN:1573-2568
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Up to 14 % of upper gastrointestinal cancer (UGIC) subjects underwent esophago-gastro-duodenoscopy (EGD) in the preceding 3 years, which did not detect UGIC. The frequency of such events and associated risk factors was evaluated. METHODS: UGIC subjects were identified from a UK primary care database. Post-EGD upper gastrointestinal cancers (PEUGIC) cases were subjects undergoing EGD 12-36 months prior to UGIC diagnosis. Controls had not undergone EGD during the same period. Logistic regression analysis examined associations with PEUGIC. RESULTS: 4249 gastric cancer (GC) subjects (44.8 %) and 5238 esophageal cancer (EC) subjects (55.2 %) were analyzed. There were 633 (6.7 %) PEUGIC subjects [279 EC and 354 GC]. Multivariate analysis revealed that younger age [OR 1.02, (95 % CI 1.01-1.03), p < 0.0001], female gender [1.39 (1.17-1.64), p < 0.0001], increasing comorbidity [1.35 (1.13-1.61), p < 0.0001], and greater deprivation [1.31 (1.09-1.59), p = 0.005] were associated with PEUGIC. Alarm symptoms on presentation [0.32 (0.26-0.40), p < 0.0001] were less likely to be associated with PEUGIC. GC was more likely to be associated with PEUGIC than EC [1.33 (1.13-1.58), p = 0.001]. PEUGIC EGDs reported findings associated with UGIC (stricture or ulceration) in 8.3 % of cases, and only 60.9 % had a follow-up EGD within 90 days. PEUGIC rate declined from 7.9 to 2.7 % for EC and 9.0-6.5 % for GC during the study period. CONCLUSIONS: PEUGIC occurs in 6.7 % of UGIC. PEUGIC was associated with GC, younger age, female gender, increasing comorbidity and deprivation, and a lack of alarm symptoms.
[Mh] Termos MeSH primário: Erros de Diagnóstico/estatística & dados numéricos
Endoscopia do Sistema Digestório
Neoplasias Esofágicas/diagnóstico
Classe Social
Neoplasias Gástricas/diagnóstico
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Estudos de Casos e Controles
Comorbidade
Úlcera Duodenal/epidemiologia
Duodenite/epidemiologia
Neoplasias Esofágicas/epidemiologia
Estenose Esofágica/epidemiologia
Esofagite/epidemiologia
Feminino
Gastrite/epidemiologia
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Análise Multivariada
Razão de Chances
Estudos Retrospectivos
Fatores de Risco
Fatores Sexuais
Neoplasias Gástricas/epidemiologia
Úlcera Gástrica/epidemiologia
Reino Unido/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE
[do] DOI:10.1007/s10620-016-4176-4


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[PMID]:27125439
[Au] Autor:Gimiga N; Olaru C; Diaconescu S; Miron I; Burlea M
[Ad] Endereço:Department of Pediatrics, St. Mary Children's Emergency Hospital, Jassy, Romania - turti23@yahoo.com.
[Ti] Título:Upper gastrointestinal bleeding in children from a hospital center of Northeast Romania.
[So] Source:Minerva Pediatr;68(3):189-95, 2016 Jun.
[Is] ISSN:1827-1715
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to investigate the common etiologies, clinical and biological patterns of upper gastrointestinal bleeding (UGIB) in children from a hospital center in Northeast Romania. METHODS: This seven-year retrospective study was performed from 2007 to 2013 in St. Mary Children's Emergency Hospital, Jassy, Romania and included all children who referred to our center with UGIB exteriorized by hematemesis or melena. Endoscopy was performed under conscious sedation/general anesthesia after the informed consent was obtained. RESULTS: One hundred and three patients aged 1-18 years were included in this study. There were 57 males and 46 females with male to female ratio 1.2:1; 43.69% presented with hematemesis, 31.07% had melena and 25.24% had both. The most common causes of UGIB were erosive gastritis (33.98%), followed by esophagitis (14.56%), duodenitis (11.65%), duodenal ulcer (10.68%), gastric ulcer (5.83%), esophageal varices (4.85%), Mallory-Weiss syndrome (1.94%); multiple etiologies counted for 16.50% cases. A certain bleeding source was found in 34.95% cases, a possible one in 39.81% of the patients; the source could not be ascertained in 25.24% of cases. Nonsteroidal anti-inflammatory drug (NSAID) consumption was documented in in 17.51% of patients. The incidence of H. pylori infection was 36.89%. CONCLUSIONS: The most common cause of of upper GI bleeding in our series was gastritis, followed by oesophagitis and duodenitis. Most of the patients presented with hematemesis; previous consumption of NSAIDs and H. pylori infection were associated with gastroduodenal ulceration and bleeding. Early endoscopy was associated with a higher detection rate of the bleeding source.
[Mh] Termos MeSH primário: Endoscopia Gastrointestinal/métodos
Hemorragia Gastrointestinal/etiologia
Hematemese/etiologia
Melena/etiologia
[Mh] Termos MeSH secundário: Adolescente
Anti-Inflamatórios não Esteroides/efeitos adversos
Criança
Pré-Escolar
Duodenite/complicações
Duodenite/diagnóstico
Duodenite/epidemiologia
Esofagite/complicações
Esofagite/diagnóstico
Esofagite/epidemiologia
Feminino
Gastrite/complicações
Gastrite/diagnóstico
Gastrite/epidemiologia
Hemorragia Gastrointestinal/patologia
Infecções por Helicobacter/complicações
Infecções por Helicobacter/diagnóstico
Infecções por Helicobacter/epidemiologia
Hematemese/epidemiologia
Seres Humanos
Incidência
Lactente
Masculino
Melena/epidemiologia
Úlcera Péptica/complicações
Úlcera Péptica/diagnóstico
Úlcera Péptica/epidemiologia
Estudos Retrospectivos
Romênia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160430
[St] Status:MEDLINE


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[PMID]:26933151
[Au] Autor:Trehan I; Kelly P; Shaikh N; Manary MJ
[Ad] Endereço:Department of Pediatrics, Washington University in St Louis, St Louis, Missouri, USA Department of Paediatrics and Child Health, University of Malawi, Blantyre, Malawi.
[Ti] Título:New insights into environmental enteric dysfunction.
[So] Source:Arch Dis Child;101(8):741-4, 2016 Aug.
[Is] ISSN:1468-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Environmental enteric dysfunction (EED) has been recognised as an important contributing factor to physical and cognitive stunting, poor response to oral vaccines, limited resilience to acute infections and ultimately global childhood mortality. The aetiology of EED remains poorly defined but the epidemiology suggests a multifactorial combination of prenatal and early-life undernutrition and repeated infectious and/or toxic environmental insults due to unsanitary and unhygienic environments. Previous attempts at medical interventions to ameliorate EED have been unsatisfying. However, a new generation of imaging and '-omics' technologies hold promise for developing a new understanding of the pathophysiology of EED. A series of trials designed to decrease EED and stunting are taking novel approaches, including improvements in sanitation, hygiene and nutritional interventions. Although many challenges remain in defeating EED, the global child health community must redouble their efforts to reduce EED in order to make substantive improvements in morbidity and mortality worldwide.
[Mh] Termos MeSH primário: Duodenite/epidemiologia
Meio Ambiente
Doenças do Jejuno/epidemiologia
[Mh] Termos MeSH secundário: Criança
Duodenite/microbiologia
Endoscopia Gastrointestinal
Enterite/epidemiologia
Enterite/microbiologia
Enterite/patologia
Microbioma Gastrointestinal
Saúde Global
Transtornos do Crescimento/epidemiologia
Transtornos do Crescimento/microbiologia
Transtornos do Crescimento/patologia
Nível de Saúde
Seres Humanos
Mucosa Intestinal
Doenças do Jejuno/microbiologia
Doenças do Jejuno/patologia
Microscopia Confocal
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2015-309534



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