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[PMID]: 29458667 [Au] Autor: Atrisco-Morales J; Martínez-Santos VI; Román-Román A; Alarcón-Millán J; De Sampedro-Reyes J; Cruz-Del Carmen I; Martínez-Carrillo DN; Fernández-Tilapa G [Ad] Endereço: 1​Laboratorio de Investigación Clínica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas s/n C.U. Sur. Chilpancingo, Guerrero, C.P. 39090, Mexico. [Ti] Título: vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis. [So] Source: J Med Microbiol;67(3):314-324, 2018 Mar. [Is] ISSN: 1473-5644 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: PURPOSE: Virulent genotypes of Helicobacter pylori vacA s1m1/cagA /babA2 have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of H. pylori by type of chronic gastritis; (ii) to describe the frequency of cagA, babA2 and vacA genotypes in strains from patients with different types of chronic gastritis; (iii) to characterize the variable region of cagA alleles. METHODOLOGY: A total of 164 patients with chronic gastritis were studied. Altogether, 50 H. pylori strains were isolated, and the status of cagA, babA2 and vacA genotypes was examined by PCR. cagA EPIYA segment identification was performed using PCR and sequencing of cagA fragments of six randomly selected strains.Results/Key findings. The overall prevalence of H. pylori was 30.5 %. Eighty percent of the isolated strains were vacA s1m1, and the cagA and babA2 genes were detected in 74 and 32 % of the strains, respectively. The most frequent genotypes were vacA s1m1/cagA /babA2 and vacA s1m1/cagA /babA2 , with 40 % (20/50) and 28 % (14/50), respectively. In cagA , the most frequent EPIYA motif was -ABC (78.4 %), and EPIYA-ABCC and -ABCCC motifs were found in 10.8 % of the strains. A modified EPIYT-B motif was found in 66.6 % of the sequenced strains. CONCLUSION: H. pylori strains carrying vacA s1m1, cagA and babA2 genotypes were the most prevalent in patients with chronic gastritis from the south of Mexico. In the cagA strains, the EPIYA-ABC motif was the most common. [Mh] Termos MeSH primário: Antígenos de Bactérias/genética Proteínas de Bactérias/genética Gastrite/microbiologia Infecções por Helicobacter/microbiologia Helicobacter pylori/genética [Mh] Termos MeSH secundário: Adulto Idoso Alelos Doença Crônica/epidemiologia Feminino Gastrite/epidemiologia Gastroscopia Genótipo Helicobacter pylori/isolamento & purificação Seres Humanos Masculino México/epidemiologia Meia-Idade Reação em Cadeia da Polimerase Estômago/microbiologia Estômago/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (VacA protein, Helicobacter pylori); 0 (cagA protein, Helicobacter pylori) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180221 [St] Status: MEDLINE [do] DOI: 10.1099/jmm.0.000660

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[PMID]: 28458166 [Au] Autor: Melchiades JL; Zabaglia LM; Sallas ML; Orcini WA; Chen E; Smith MAC; Payão SLM; Rasmussen LT [Ad] Endereço: Universidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil. [Ti] Título: Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori. [So] Source: Cytokine;96:203-207, 2017 08. [Is] ISSN: 1096-0023 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Interleukin 2 (IL-2) is a pro-inflammatory cytokine that is mainly synthesized by immunoregulatory T helper cells and which plays an important role in antitumor immunity. Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric mucosa and induces the production of IL-2. This process increases the magnitude of inflammation and may influence the development of gastric pathologies. In light of the possible involvement of IL-2 and the presence of H. pylori in gastric diseases, this study investigated possible associations between the IL-2 polymorphisms +114 T>G (rs2069763) and -330 T>G (rs2069762) and the development of gastric cancer; these associations were then correlated with the presence of H. pylori. Gastric biopsies were obtained from 294 dyspeptic patients (173♀/123♂). Of these samples, 181 were chronic gastritis samples (102♀/79), 62 were samples of intact gastric mucosa (47♀/15♂), and 51 were samples of gastric cancer (22♀/29♂). PCR-RFLP was used to characterize the +114 T>G and -330 T>G polymorphisms. Considering the genetic characteristics of the study population and based on the codominant model, a high risk of gastric cancer among patients with normal gastric tissue and patients with gastric cancer was found in subjects with the IL-2-330 GG genotype (OR=6.43, 95% CI: 1.47-28.10, p=0.044). The data was adjusted for the presence of H. pylori. Among patients with gastritis and patients with gastric cancer, a high risk was found among subjects with the IL-2-330 GG genotype (OR=4.47, 95% CI: 1.84-10.84, p=0.0022). When the IL-2 +114 polymorphism was analyzed, similar results were found. Among the patients with normal gastric tissue and the patients with gastric cancer, subjects carrying the +114 TT genotype were found to be at a high risk of gastric cancer (OR=5.97, 95% CI: 1.60-22.27, p=0.013). This data was also adjusted for the presence of H. pylori. Among patients with gastritis and patients with gastric cancer, a high risk was found in subjects carrying the +114 TT genotype (OR=6.36, 95% CI: 2.66-15.21, p<0.0001). The haplotype was also analyzed. The -330G/+114T haplotype was found to be significantly associated with gastric cancer. Therefore, our results show that, among patients with H. pylori infection, the -330 GG and +114 TT genotypes are significantly associated with a high risk of developing gastric cancer, as is the -330G/+114T haplotype. [Mh] Termos MeSH primário: Infecções por Helicobacter/complicações Interleucina-2/genética Polimorfismo de Nucleotídeo Único Neoplasias Gástricas/genética [Mh] Termos MeSH secundário: Adulto Idoso Grupo com Ancestrais do Continente Asiático Biópsia Feminino Gastrite/microbiologia Estudos de Associação Genética Predisposição Genética para Doença Genótipo Haplótipos Infecções por Helicobacter/imunologia Helicobacter pylori/isolamento & purificação Seres Humanos Masculino Meia-Idade Polimorfismo de Fragmento de Restrição Estômago/patologia Neoplasias Gástricas/microbiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Interleukin-2) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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[PMID]: 29222050 [Au] Autor: Li N; Cao M; Yi S; Cheng J; Wang L; Tao Y; Wu D; Peng J; Zhang M; Qi P; Zhao J [Ad] Endereço: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, Sichuan, PR China. [Ti] Título: Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice. [So] Source: Biochem Biophys Res Commun;495(2):1573-1579, 2018 01 08. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous inflammatory-related genes that participate in complex biological response of cells to harmful stimuli. Here we studied effects of the KH-type splicing regulatory protein (KSRP), a RNA-binding protein, on innate immune response against H. pylori infection. We found that H. pylori infection downregulated KSRP expression directly, and that KSRP overexpression repressed upregulation of CXCL-2 expression induced by H. pylori and facilitated H. pylori proliferation in vitro. Similarly, KSRP overexpression in H. pylori mice also facilitated H. pylori proliferation and colonization, and induced more severe gastric mucosal damage. Intriguingly, CXCL-2 and HMOX-1 were upregulated in H. pylori infected mice after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori. These results were beneficial for understanding the in vivo function of KSRP on innate immune response against pathogen infection. [Mh] Termos MeSH primário: Infecções por Helicobacter/imunologia Helicobacter pylori Proteínas de Ligação a RNA/imunologia Transativadores/imunologia [Mh] Termos MeSH secundário: Animais Linhagem Celular Quimiocina CXCL2/genética Regulação para Baixo Feminino Gastrite/genética Gastrite/imunologia Gastrite/patologia Infecções por Helicobacter/genética Infecções por Helicobacter/patologia Helicobacter pylori/genética Helicobacter pylori/imunologia Helicobacter pylori/patogenicidade Heme Oxigenase-1/genética Seres Humanos Imunidade Inata/genética Masculino Proteínas de Membrana/genética Camundongos Camundongos Endogâmicos BALB C Proteínas de Ligação a RNA/genética Receptor 2 Toll-Like/genética Transativadores/genética Regulação para Cima [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (CXCL2 protein, human); 0 (Chemokine CXCL2); 0 (Cxcl2 protein, mouse); 0 (KHSRP protein, human); 0 (KSRP protein, mouse); 0 (Membrane Proteins); 0 (RNA-Binding Proteins); 0 (TLR2 protein, human); 0 (Tlr2 protein, mouse); 0 (Toll-Like Receptor 2); 0 (Trans-Activators); EC 1.14.14.18 (HMOX1 protein, human); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171210 [St] Status: MEDLINE

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[PMID]: 28455456 [Au] Autor: Inayat F; Ullah W; Hussain Q; Shafique K [Ad] Endereço: New York-Presbyterian Hospital, Weill Cornell Medical College, New York City, New York, USA. [Ti] Título: Crohn's disease presenting as gastric outlet obstruction: a therapeutic challenge? [So] Source: BMJ Case Rep;2017, 2017 Apr 28. [Is] ISSN: 1757-790X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Isolated gastric Crohn's disease with initial presentation related to gastric outlet obstruction is an unusual clinicopathological entity. We undertake here a literature review of this rare initial presentation of isolated gastric Crohn's disease and discuss the formidable diagnostic and therapeutic challenges encountered in such patients. [Mh] Termos MeSH primário: Doença de Crohn/complicações Doença de Crohn/patologia Obstrução da Saída Gástrica/complicações Obstrução da Saída Gástrica/patologia [Mh] Termos MeSH secundário: Adulto Doença de Crohn/diagnóstico Endoscopia do Sistema Digestório/métodos Endoscopia Gastrointestinal/métodos Feminino Obstrução da Saída Gástrica/diagnóstico por imagem Gastrite/diagnóstico Gastrite/etiologia Seres Humanos Estômago/patologia Gastropatias/patologia Tomografia Computadorizada por Raios X/métodos Resultado do Tratamento Perda de Peso [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170430 [St] Status: MEDLINE

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[PMID]: 29328644 [Au] Autor: Grgov S; Tasic T; Radovanovic-Dinic B; Benedeto-Stojanov D [Ti] Título: Can probiotics improve efficiency and safety profile of triple Helicobacter pylori eradication therapy? A prospective randomized study. [So] Source: Vojnosanit Pregl;73(11):1044-9, 2016 Nov. [Is] ISSN: 0042-8450 [Cp] País de publicação: Serbia [La] Idioma: eng [Ab] Resumo: Background/Aim: Some studies suggest the benefit of applying different probiotic strains in combination with antibiotics in the eradication of Helicobacter pylori (H. pylori) infection. The aim of this study was to evaluate the effect of co-administration of multiple probiotic strains with triple H. pylori eradication therapy.This prospective study included 167 patients with dyspeptic symptoms and chronic gastritis who were diagnosed with H. pylori infection and randomized into two groups. The group I of 77 patients underwent triple eradication therapy, for 7 days, with lansoprazole, 2 × 30 mg half an hour before the meal, amoxicillin 2 × 1.000 mg per 12 hours and clarithromycin 2 × 500 mg per 12 hours. After the 7th day of the therapy, lansoprazole continued at a dose of 30 mg for half an hour before breakfast for 4 weeks. The group II of 90 patients received the same treatment as the patients of the group I, with the addition of the probiotic cultures in the form of a capsule comprising Lactobacillus Rosell-52, Lactobacillus Rosell-11, Bifidobacterium Rosell-1755 and Saccharomyces boulardii, since the beginning of eradication for 4 weeks. Eradication of H. pylori infection control was performed 8 weeks after the therapy by rapid urease test and histopathologic evaluation of endoscopic biopsies or by stool antigen test for H. pylori.Eradication of H. pylori infection was achieved in 93.3% of the patients who received probiotics with eradication therapy and in 81.8% of patients who were only on eradication therapy without probiotics. The difference in eradication success was statistically significant, (p < 0.05). The incidence of adverse effects of eradication therapy was higher in the group of patients who were not on probiotic (28.6%) than in the group that received probiotic (17.7%), but the difference was not statistically significant.Multiple probiotic strains addition to triple eradication therapy of H. pylori achieves a significantly better eradication success, with fewer side effects of antibiotics. [Mh] Termos MeSH primário: Amoxicilina/uso terapêutico Antibacterianos/uso terapêutico Claritromicina/uso terapêutico Gastrite/tratamento farmacológico Infecções por Helicobacter/tratamento farmacológico Helicobacter pylori/efeitos dos fármacos Lansoprazol/uso terapêutico Probióticos/uso terapêutico Inibidores da Bomba de Prótons/uso terapêutico [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Amoxicilina/efeitos adversos Antibacterianos/efeitos adversos Biópsia Doença Crônica Claritromicina/efeitos adversos Quimioterapia Combinada Feminino Gastrite/diagnóstico Gastrite/microbiologia Gastroscopia Infecções por Helicobacter/diagnóstico Infecções por Helicobacter/microbiologia Helicobacter pylori/patogenicidade Seres Humanos Lansoprazol/efeitos adversos Masculino Meia-Idade Probióticos/efeitos adversos Estudos Prospectivos Inibidores da Bomba de Prótons/efeitos adversos Sérvia Fatores de Tempo Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Proton Pump Inhibitors); 0K5C5T2QPG (Lansoprazole); 804826J2HU (Amoxicillin); H1250JIK0A (Clarithromycin) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180213 [Lr] Data última revisão: 180213 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.2298/VSP150415127G

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[PMID]: 29179204 [Au] Autor: Li GQ; He Q; Yang L; Wang SB; Yu DD; He YQ; Hu J; Pan YM; Wu Y [Ad] Endereço: Inner Mongolia Medical College, Huhhot, China. [Ti] Título: Clinical Significance of Myeloid Zinc Finger 1 Expression in the Progression of Gastric Tumourigenesis. [So] Source: Cell Physiol Biochem;44(3):1242-1250, 2017. [Is] ISSN: 1421-9778 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIMS: To investigate the clinical significance of myeloid zinc finger 1 (MZF1) expression in various gastric mucosal lesions including chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), intestinal metaplasia (IM), dysplasia (DYS) and gastric cancer (GC) in comparison with normal tissues and gastric cell lines. METHODS: MZF1 protein expression was detected using immunohistochemical staining in 37 CSG, 88 CAG, 77 IM, 51 DYS, 165 GC and 8 normal tissue samples. Quantitative real-time PCR (qRT-PCR) and western blotting were used to detect the level of MZF1 in gastric cell lines, 15 normal tissues and 34 GC samples, as well as 2 groups of paired primary GC and adjacent normal samples. RESULTS: Reduced MZF1 expression was detected in most GC cells and tissues. Among the gastric tissues consisting of various stages of lesions (normal, CSG, CAG, IM, DYS and GC), MZF1 protein expression was downregulated in precancerous lesions and GC. The data from clinical analyses showed that decreased MZF1 expression was correlated with tumour invasion (p = 0.044), lymph node metastasis (p = 0.048) and poor prognosis of GC patients (p = 0.003). Moreover, MZF1 was identified as an independent prognostic biomarker for GC patients in multivariate Cox regression analysis (p = 0.009). CONCLUSION: Downregulation of MZF1 was associated with gastric tumourigenesis, which may be a novel early predictive and prognostic biomarker in GC patients. [Mh] Termos MeSH primário: Fatores de Transcrição Kruppel-Like/metabolismo Neoplasias Gástricas/patologia [Mh] Termos MeSH secundário: Adulto Fatores Etários Idoso Idoso de 80 Anos ou mais Biomarcadores Tumorais/genética Biomarcadores Tumorais/metabolismo Linhagem Celular Tumoral Progressão da Doença Regulação para Baixo Feminino Mucosa Gástrica/metabolismo Mucosa Gástrica/patologia Gastrite/metabolismo Gastrite/patologia Seres Humanos Imuno-Histoquímica Fatores de Transcrição Kruppel-Like/genética Metástase Linfática Masculino Metaplasia/metabolismo Metaplasia/patologia Microscopia de Fluorescência Meia-Idade Análise Multivariada Estadiamento de Neoplasias Lesões Pré-Cancerosas Prognóstico Modelos de Riscos Proporcionais Reação em Cadeia da Polimerase em Tempo Real Fatores Sexuais Neoplasias Gástricas/diagnóstico Neoplasias Gástricas/mortalidade Taxa de Sobrevida [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers, Tumor); 0 (Kruppel-Like Transcription Factors); 0 (MZF1 protein, human) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180118 [Lr] Data última revisão: 180118 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE [do] DOI: 10.1159/000485454

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[PMID]: 27771376 [Au] Autor: Dudley J; Wieczorek T; Selig M; Cheung H; Shen J; Odze R; Deshpande V; Zukerberg L [Ad] Endereço: Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: jonathan.dudley@stanford.edu. [Ti] Título: Clinicopathological characteristics of invasive gastric Helicobacter pylori. [So] Source: Hum Pathol;61:19-25, 2017 03. [Is] ISSN: 1532-8392 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Helicobacter pylori organisms have been observed deep within the stomach mucosa with an "intracellular" appearance, although the clinicopathological characteristics of such cases remain poorly understood. We analyzed 18 cases of deep mucosal H pylori and associated clinical (sex, age, history of H pylori infection, or proton pump inhibitor [PPI] use, medications, smoking, alcohol use, comorbidities, treatment response) and pathological (presence of lymphoid aggregates, intestinal metaplasia, PPI effect, active and/or chronic inflammation, quantity of invasive versus surface H pylori) characteristics. Electron microscopy was performed on 6 cases with the highest burden of invasive H pylori. Within our sample, 3 of 16 had a history of H pylori infection, 10 of 15 were receiving PPIs at the time of biopsy, and 12 of 13 had a negative posttreatment follow-up. Histology revealed that invasive H pylori were more commonly associated with chronic inflammation, in both the antrum (15/15 chronic, 8/15 acute) and fundus (17/18 chronic, 8/18 acute). Electron microscopy showed organisms within intercellular and luminal spaces, but no intracellular organisms. Deep mucosal H pylori often have an intracellular appearance but are contained within intercellular and luminal spaces and are responsive to standard therapy. [Mh] Termos MeSH primário: Mucosa Gástrica/microbiologia Mucosa Gástrica/ultraestrutura Gastrite/microbiologia Gastrite/patologia Infecções por Helicobacter/microbiologia Infecções por Helicobacter/patologia Helicobacter pylori/ultraestrutura [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Antibacterianos/uso terapêutico Biópsia Quimioterapia Combinada Feminino Mucosa Gástrica/efeitos dos fármacos Gastrite/tratamento farmacológico Infecções por Helicobacter/tratamento farmacológico Helicobacter pylori/efeitos dos fármacos Helicobacter pylori/patogenicidade Seres Humanos Masculino Microscopia Eletrônica de Transmissão Meia-Idade Valor Preditivo dos Testes Inibidores da Bomba de Prótons/uso terapêutico Fatores de Tempo Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Proton Pump Inhibitors) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 180117 [Lr] Data última revisão: 180117 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 28906408 [Au] Autor: Chen B; Yang Z; Lu H; Wei C; Wang F; Liu C [Ad] Endereço: aDepartment of Gastroenterology and Hepatology, Jinling Hospital, School of Medicine, Southern Medical University bDepartment of Gastroenterology and Hepatology, Jinling Hospital cDepartment of Gastroenterology and Hepatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China. [Ti] Título: Eosinophilic gastroenteritis presenting as upper gastrointestinal hematoma and ulcers after endoscopic biopsy: A case report and literature review. [So] Source: Medicine (Baltimore);96(37):e8075, 2017 Sep. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: Eosinphilic gastroenteritis (EG) is a gastrointestinal disorder characterized by eosinophilic infiltration with various manifestations. The diagnosis is usually confirmed by an endoscopic biopsy, which is considered a safe and routine procedure for the majority. PATIENT CONCERNS: We report a 54-year-old male who was presented with intermittent periumbilical pain and melena, and only revealed verrucous gastritis by endoscopy. DIAGNOSES: The patient's condition worsened two days after the endoscopic biopsy, and another endoscopy found hematoma and ulcers in upper gastrointestinal tract. He was diagnosed with EG by the pathological analysis of biopsy specimen. INTERVENTIONS: Oral methylprednisolone and Montelukast were prescribed. OUTCOMES: The patient got remission after initiation of the treatment. LESSONS: This case highlights an extremely rare but potentially severe complication of endoscopic biopsies in patients with EG. Physicians should be cautious with hematoma or ulceration, and consider it in such patients who undergo this procedure. [Mh] Termos MeSH primário: Úlcera Duodenal/etiologia Endoscopia Gastrointestinal/efeitos adversos Enterite/diagnóstico Eosinofilia/diagnóstico Gastrite/diagnóstico Hemorragia Gastrointestinal/etiologia Hematoma/etiologia Úlcera Gástrica/etiologia [Mh] Termos MeSH secundário: Úlcera Duodenal/diagnóstico Enterite/tratamento farmacológico Enterite/patologia Eosinofilia/tratamento farmacológico Eosinofilia/patologia Mucosa Gástrica/patologia Gastrite/tratamento farmacológico Gastrite/patologia Hemorragia Gastrointestinal/diagnóstico Hematoma/diagnóstico Hematoma/tratamento farmacológico Seres Humanos Masculino Meia-Idade Úlcera Gástrica/diagnóstico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171004 [Lr] Data última revisão: 171004 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170915 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000008075

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[PMID]: 28874038 [Au] Autor: Cheung DY [Ad] Endereço: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. [Ti] Título: Atrophic Gastritis Increases the Risk of Gastric Cancer in Asymptomatic Population in Korea. [So] Source: Gut Liver;11(5):575-576, 2017 09 15. [Is] ISSN: 2005-1212 [Cp] País de publicação: Korea (South) [La] Idioma: eng [Mh] Termos MeSH primário: Gastrite Atrófica/epidemiologia Infecções por Helicobacter [Mh] Termos MeSH secundário: Gastrite/epidemiologia Helicobacter pylori Seres Humanos República da Coreia Neoplasias Gástricas/epidemiologia [Pt] Tipo de publicação: EDITORIAL; COMMENT [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171031 [Lr] Data última revisão: 171031 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170907 [St] Status: MEDLINE [do] DOI: 10.5009/gnl17356

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[PMID]: 28739826 [Au] Autor: Tanaka S; Nagashima H; Cruz M; Uchida T; Uotani T; Jiménez Abreu JA; Mahachai V; Vilaichone RK; Ratanachu-Ek T; Tshering L; Graham DY; Yamaoka Y [Ad] Endereço: Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA. [Ti] Título: Interleukin-17C in Human Helicobacter pylori Gastritis. [So] Source: Infect Immun;85(10), 2017 Oct. [Is] ISSN: 1098-5522 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The interleukin-17 (IL-17) family of cytokines (IL-17A to IL-17F) is involved in many inflammatory diseases. Although IL-17A is recognized as being involved in the pathophysiology of -associated diseases, the role of other IL-17 cytokine family members remains unclear. Microarray analysis of IL-17 family cytokines was performed in -infected and uninfected gastric biopsy specimens. mRNA was upregulated approximately 4.5-fold in -infected gastric biopsy specimens. This was confirmed by quantitative reverse transcriptase PCR in infected and uninfected gastric mucosa obtained from Bhutan and from the Dominican Republic. Immunohistochemical analysis showed that IL-17C expression in -infected gastric biopsy specimens was predominantly localized to epithelial and chromogranin A-positive endocrine cells. mRNA levels were also significantly greater among -positive than -negative infections ( = 0.012). studies confirmed an increase in mRNA and protein levels in cells infected with -positive infections compared to cells infected with either -negative or pathogenicity island (PAI) mutant. Chemical inhibition of IκB kinase (IKK), mitogen-activated protein extracellular signal-regulated kinase (MEK), and Jun N-terminal kinase (JNK) inhibited induction of IL-17C proteins in infected cells, whereas p38 inhibition had no effect on IL-17C protein secretion. In conclusion, infection was associated with a significant increase in IL-17C expression in human gastric mucosa. The role of IL-17C in the pathogenesis of -induced diseases remains to be determined. [Mh] Termos MeSH primário: Mucosa Gástrica/imunologia Gastrite/imunologia Infecções por Helicobacter/imunologia Helicobacter pylori/imunologia Interleucina-17/genética Interleucina-17/imunologia [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Idoso de 80 Anos ou mais Proteínas de Bactérias/genética Butão Linhagem Celular República Dominicana Feminino Mucosa Gástrica/metabolismo Mucosa Gástrica/microbiologia Mucosa Gástrica/patologia Gastrite/microbiologia Gastrite/fisiopatologia Redes Reguladoras de Genes Ilhas Genômicas Genótipo Infecções por Helicobacter/epidemiologia Infecções por Helicobacter/microbiologia Helicobacter pylori/genética Seres Humanos Masculino Meia-Idade RNA Mensageiro/genética Reação em Cadeia da Polimerase em Tempo Real Regulação para Cima Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Bacterial Proteins); 0 (IL17A protein, human); 0 (Interleukin-17); 0 (RNA, Messenger) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170726 [St] Status: MEDLINE

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