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[PMID]:27924798
[Au] Autor:Naumann J; Sadaghiani C; Alt F; Huber R
[Ti] Título:Effects of Sulfate-Rich Mineral Water on Functional Constipation: A Double-Blind, Randomized, Placebo-Controlled Study.
[So] Source:Forsch Komplementmed;23(6):356-363, 2016.
[Is] ISSN:1661-4127
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Magnesium sulfate has a long tradition as a laxative. It osmotically prevents water absorption in the large bowel and thus leads to an acceleration of the intestinal transit and better stool consistency. We wanted to investigate the efficacy of a carbonated calcium/magnesium sulfate-rich natural mineral water in subjects with functional constipation (FC). PATIENTS AND METHODS: In this double-blind, randomized, placebo-controlled study, subjects with FC (Rome III criteria) received 1 l/day (4 × 250 ml) of mineral water (Ensinger Schiller Quelle) or carbonated tap water (placebo) for 6 weeks. The primary endpoint was the change in the frequency of bowel movements per week between baseline and visit 4 (after 6 weeks). The prespecified main secondary endpoint was the change in the frequency of bowel movements per week between baseline and visit 3 (after 3 weeks). RESULTS: Efficacy was analyzed in 100 subjects (intention-to-treat). After 6 weeks of treatment there was no statistical difference between the groups (p = 0.163). However, statistical significance was reached after 3 weeks, with an increase in the frequency of bowel movements per week of 2.02 ± 2.22 for the mineral water group compared to 0.88 ± 1.67 for the placebo group (p = 0.005). CONCLUSIONS: A 3-week treatment with 1 l/day of the sulfate-rich mineral water improved the frequency of bowel movements in subjects with FC compared with tap water; however, the difference was no longer significant after 6 weeks. Further evaluation in rigorously designed clinical studies will be necessary to validate the impact of sulfate-rich natural mineral water on FC.
[Mh] Termos MeSH primário: Água Carbonatada/uso terapêutico
Doenças Funcionais do Colo/terapia
Constipação Intestinal/terapia
Sulfato de Magnésio/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Relação Dose-Resposta a Droga
Método Duplo-Cego
Feminino
Seguimentos
Alemanha
Fidelidade a Diretrizes
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Carbonated Water); 7487-88-9 (Magnesium Sulfate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161208
[St] Status:MEDLINE
[do] DOI:10.1159/000449436


  2 / 3578 MEDLINE  
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[PMID]:26628103
[Au] Autor:Quigley EM
[Ad] Endereço:Division of Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital, Weill Cornell Medical College, Houston, Texas, USA.
[Ti] Título:Advances in colonic disease: some light at the end of the tunnel at the end of the light!
[So] Source:Curr Opin Gastroenterol;32(1):24-5, 2016 Jan.
[Is] ISSN:1531-7056
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Doenças Funcionais do Colo/diagnóstico
Neoplasias Colorretais/diagnóstico
Detecção Precoce de Câncer/tendências
[Mh] Termos MeSH secundário: Doenças Funcionais do Colo/terapia
Neoplasias Colorretais/terapia
Seres Humanos
Guias de Prática Clínica como Assunto
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151204
[Lr] Data última revisão:
151204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE
[do] DOI:10.1097/MOG.0000000000000231


  3 / 3578 MEDLINE  
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[PMID]:26574870
[Au] Autor:Dinning PG; Carrington EV; Scott SM
[Ad] Endereço:aDepartment of Surgery and Gastroenterology, Flinders Medical Centre, Flinders University, Adelaide, South Australia, Australia bNational Centre for Bowel Research and Surgical Innovation and the GI Physiology Unit, Queen Mary University of London, London, United Kingdom.
[Ti] Título:Colonic and anorectal motility testing in the high-resolution era.
[So] Source:Curr Opin Gastroenterol;32(1):44-8, 2016 Jan.
[Is] ISSN:1531-7056
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: The past few years have seen an increase in the number of research and clinical groups around the world using high-resolution manometry (HRM) to record contractile activity in the anorectum and colon. Yet despite the uptake and growing number of publications, the clinical utility and potential advantages over traditional manometry remain undetermined. RECENT FINDINGS: Nearly all of the publications in the field of anorectal and colonic HRM have been published within the last 3 years. These studies have included some data on normal ranges in healthy adults, and abnormalities in patient groups with constipation or fecal incontinence, anal fissure, perineal descent, rectal cancer, and Hirschsprung's disease. Most of the studies have been conducted on adults, with only three published studies in pediatric populations. Very few studies have attempted to show advantages of HRM over traditional manometry SUMMARY: High-resolution anorectal and colonic manometry provide a more comprehensive characterization of motility patterns and coordinated activity; this may help to improve our understanding of the normal physiology and pathophysiology in these regions. To date, however, no published study has conclusively demonstrated a clinical, diagnostic, or interventional advantage over conventional manometry.
[Mh] Termos MeSH primário: Canal Anal/patologia
Colo/patologia
Doenças Funcionais do Colo/fisiopatologia
Manometria/instrumentação
Doenças Retais/fisiopatologia
Reto/patologia
[Mh] Termos MeSH secundário: Doenças Funcionais do Colo/diagnóstico
Motilidade Gastrointestinal
Seres Humanos
Manometria/métodos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151202
[Lr] Data última revisão:
151202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE
[do] DOI:10.1097/MOG.0000000000000229


  4 / 3578 MEDLINE  
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[PMID]:26519287
[Au] Autor:Lehto K; Hyöty M; Collin P; Janhunen J; Aitola P
[Ad] Endereço:Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, School of Medicine Tampere, PO Box 2000, 33521, Tampere, Finland. kirsi.lehto@uta.fi.
[Ti] Título:Antegrade transverse or sigmoid colonic enema through a percutaneous endoscopic gastrostomy tube is an option in the treatment of colorectal dysfunction.
[So] Source:Tech Coloproctol;20(1):25-9, 2016 Jan.
[Is] ISSN:1128-045X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antegrade colonic enemas are used in patients with colorectal dysfunction resistant to conservative therapy. A number of different operative techniques are applied, but their effectiveness is by and large unknown. We therefore evaluated the long-term usefulness of the left-sided percutaneous endoscopic gastrostomy (PEG) tube method in adult patients. METHODS: Twenty-one patients with colorectal dysfunction underwent insertion of a PEG tube colostomy by laparotomy between 1997 and 2006. In 2014, we evaluated how many of the patients had the tube still in place, how the patients coped with the tube, and what the reasons for the removal were. RESULTS: The main indications were severe constipation or fecal incontinence mainly related to neurological diseases. In 2014, 5 out of 21 patients had the tube still in use (median follow-up 14 years, range 11-17 years) and 4 out of 5 deceased patients had had the tube in use until their death, unrelated to this treatment (median follow-up 7 years, range 0-8 years). Four out of the 5 living patients considered the benefit of the tube to be good or excellent. Tubes were removed in 11 (52%) patients for various reasons, local skin irritation being the most common. CONCLUSIONS: A left-sided PEG tube colostomy was removed in over half of the patients, but despite that, it still seems to be a viable long-term option in the treatment of individual patients with colorectal dysfunction, when conservative methods are ineffective.
[Mh] Termos MeSH primário: Doenças Funcionais do Colo/terapia
Endoscopia Gastrointestinal/métodos
Enema/métodos
Gastrostomia/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Colo Sigmoide/cirurgia
Constipação Intestinal/terapia
Incontinência Fecal/terapia
Feminino
Seguimentos
Gastrostomia/instrumentação
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1610
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151101
[St] Status:MEDLINE
[do] DOI:10.1007/s10151-015-1384-4


  5 / 3578 MEDLINE  
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[PMID]:26020373
[Au] Autor:Varni JW; Nurko S; Shulman RJ; Self MM; Saps M; Bendo CB; Vaughan Dark C; Pohl JF; Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium
[Ad] Endereço:*Department of Pediatrics, College of Medicine, Texas A&M University, College Station ‡Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, Harvard Medical School, Boston, MA §Department of Pediatrics, Baylor College of Medicine, Children's Nutrition Research Center ||Departments of Psychiatry and Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston ¶Division of Gastroenterology, Hepatology, and Nutrition, Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL #Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil **Department of Psychology, Texas A&M University, College Station ††Department of Pediatric Gastroenterology, Primary Children's Hospital, University of Utah, Salt Lake City.
[Ti] Título:Pediatric Functional Constipation Gastrointestinal Symptom Profile Compared With Healthy Controls.
[So] Source:J Pediatr Gastroenterol Nutr;61(4):424-30, 2015 Oct.
[Is] ISSN:1536-4801
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Patient-reported outcomes are necessary to evaluate the gastrointestinal symptom profile of patients with functional constipation. Study objectives were to compare the gastrointestinal symptom profile of pediatric patients with functional constipation with matched healthy controls with the Pediatric Quality of Life Inventory Gastrointestinal Symptoms and Gastrointestinal Worry Scales and to establish clinical interpretability in functional constipation through identification of minimal important difference (MID) scores. The secondary objective compared the symptom profile of patients with functional constipation with patients with irritable bowel syndrome (IBS). METHODS: Gastrointestinal Symptoms and Worry Scales were completed in a 9-site study by 116 pediatric patients with functional constipation and 188 parents. Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were administered along with Gastrointestinal Worry Scales. A total of 341 families with healthy children and 43 families with patients with IBS completed the scales. RESULTS: A broad profile of gastrointestinal symptoms and worry were reported by patients with functional constipation in comparison with healthy controls (P < 0.001) with large effect sizes (>0.80) across the majority of symptom domains. Patients with IBS manifested a broader symptom profile than functional constipation, with differences for stomach pain, stomach discomfort when eating, and worry about stomachaches, with similar constipation scores. CONCLUSIONS: Pediatric patients with functional constipation report a broad gastrointestinal symptom profile in comparison with healthy controls and only somewhat fewer symptoms than patients with IBS, highlighting the critical need for more efficacious interventions to achieve healthy functioning.
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Ansiedade/etiologia
Atitude Frente à Saúde
Colo/fisiopatologia
Doenças Funcionais do Colo/diagnóstico
Constipação Intestinal/etiologia
Qualidade de Vida
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Doenças Funcionais do Colo/fisiopatologia
Doenças Funcionais do Colo/psicologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Internet
Síndrome do Intestino Irritável/diagnóstico
Síndrome do Intestino Irritável/fisiopatologia
Síndrome do Intestino Irritável/psicologia
Masculino
Ambulatório Hospitalar
Pais
Autorrelato
Índice de Gravidade de Doença
Centros de Atenção Terciária
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150924
[Lr] Data última revisão:
150924
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150529
[St] Status:MEDLINE
[do] DOI:10.1097/MPG.0000000000000869


  6 / 3578 MEDLINE  
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[PMID]:25967750
[Au] Autor:Li B; Xiao J
[Ad] Endereço:Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Hongkou, Shanghai, China.
[Ti] Título:Reply: To PMID 8600700.
[So] Source:Clin Gastroenterol Hepatol;13(8):1549, 2015 Aug.
[Is] ISSN:1542-7714
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Bloqueadores dos Canais de Cálcio/uso terapêutico
Doenças Funcionais do Colo/tratamento farmacológico
Morfolinas/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Calcium Channel Blockers); 0 (Morpholines)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150926
[Lr] Data última revisão:
150926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150514
[St] Status:MEDLINE


  7 / 3578 MEDLINE  
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[PMID]:25359460
[Au] Autor:Ng KS; Nassar N; Hamd K; Nagarajah A; Gladman MA
[Ad] Endereço:Academic Colorectal Unit, Sydney Medical School - Concord, University of Sydney, Sydney, New South Wales, Australia.
[Ti] Título:Prevalence of functional bowel disorders and faecal incontinence: an Australian primary care survey.
[So] Source:Colorectal Dis;17(2):150-9, 2015 Feb.
[Is] ISSN:1463-1318
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: Interest in functional bowel disorders (FBDs) and faecal incontinence (FI) has increased amongst coloproctologists. The study aimed to assess the prevalence of FBDs and FI (including its severity) among Australian primary healthcare seekers using objective criteria. METHOD: A cross-sectional survey was conducted in a primary care setting in Sydney, Australia. A self-administered questionnaire was used to collect demographic information and diagnose FBDs (irritable bowel syndrome, constipation, functional bloating and functional diarrhoea) based on Rome III criteria. The severity of FI was determined using the Vaizey incontinence score. Associations with medical/surgical history and healthcare utilization were assessed. RESULTS: Of 596 subjects approached, 396 (66.4%) agreed to participate. Overall, 33% had FBD and/or FI. Irritable bowel syndrome was present in 11.1% and these participants were more likely to report anxiety/depression (P < 0.01) and to have had a previous colonoscopy (P < 0.001) or cholecystectomy (P = 0.02). Functional constipation was present in 8.1%, and functional bloating and functional diarrhoea were diagnosed in 6.1%, and 1.5%, respectively. FI was present in 12.1% with the majority (52%) reporting moderate/severe incontinence (Vaizey score > 8). Participants with FI were more likely to have irritable bowel syndrome, urinary incontinence and previous anal surgery (P < 0.01). CONCLUSION: FBDs and FI are prevalent conditions amongst primary healthcare seekers and the needs of those affected appear to be complex given their coexisting symptoms and conditions. Currently, the majority do not reach colorectal services, although increased awareness by primary care providers could lead to sufferers being referred for specialist management.
[Mh] Termos MeSH primário: Doenças Funcionais do Colo/epidemiologia
Incontinência Fecal/epidemiologia
Atenção Primária à Saúde/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Canal Anal/fisiopatologia
Canal Anal/cirurgia
Ansiedade/epidemiologia
Ansiedade/etiologia
Doenças Funcionais do Colo/etiologia
Estudos Transversais
Diarreia/epidemiologia
Diarreia/etiologia
Incontinência Fecal/etiologia
Feminino
Seres Humanos
Síndrome do Intestino Irritável/epidemiologia
Síndrome do Intestino Irritável/etiologia
Masculino
Meia-Idade
New South Wales/epidemiologia
Prevalência
Estudos Prospectivos
Fatores de Risco
Índice de Gravidade de Doença
Inquéritos e Questionários
Avaliação de Sintomas/métodos
Avaliação de Sintomas/estatística & dados numéricos
Incontinência Urinária/epidemiologia
Incontinência Urinária/etiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1111/codi.12808


  8 / 3578 MEDLINE  
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[PMID]:25478715
[Au] Autor:Steger L; Höllwarth M; Rumpold G; Juen B
[Ti] Título:[Relationship Pattern of Mothers with Functional Constipated Infants].
[Ti] Título:Beziehungsmuster bei Müttern von Kleinkindern mit funktioneller Obstipation..
[So] Source:Prax Kinderpsychol Kinderpsychiatr;63(7):577-89, 2014.
[Is] ISSN:0032-7034
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:Relationship Pattern of Mothers with Functional Constipated Infants The present article investigates whether or not mothers of infants with functional constipation have a specific relationship pattern. This question is addressed by analyzing the data collected at the day care clinic for infant regulation disorders with appropriate methods like the questionnaire for the assessment of adjustment of mothers with children in infancy (EMKK, Engfer u. Codreanu, 1984) described here. The evaluation of data was performed in two ways: first with regard to the clinical study group of mothers with infants (age range from one to five years) suffering from functional constipation, and then compared to a clinical control group of mothers with infants who are coping with regulation disorders (by definition per Papousek, Schieche, Wurmser, 2010). With this comparison differences between the two groups are made visible and clinical interventions can be deduced accordingly. If the groups do not differ in their pattern described by the EMKK, the possible interventions can be adopted from the well-studied area of regulation disorders. The focus on analyzing the data of mothers with functional constipated infants serves as an important starting point for providing the best possible alignment of clinical intervention.
[Mh] Termos MeSH primário: Doenças Funcionais do Colo/psicologia
Constipação Intestinal/psicologia
Relações Mãe-Filho
[Mh] Termos MeSH secundário: Adaptação Psicológica
Transtornos de Adaptação/diagnóstico
Transtornos de Adaptação/psicologia
Transtornos de Adaptação/terapia
Sintomas Afetivos/diagnóstico
Sintomas Afetivos/psicologia
Sintomas Afetivos/terapia
Pré-Escolar
Doenças Funcionais do Colo/diagnóstico
Doenças Funcionais do Colo/terapia
Constipação Intestinal/diagnóstico
Constipação Intestinal/terapia
Hospital Dia
Deficiências do Desenvolvimento/diagnóstico
Deficiências do Desenvolvimento/psicologia
Deficiências do Desenvolvimento/terapia
Feminino
Seres Humanos
Lactente
Masculino
Comportamento Materno/psicologia
Psicometria
Inquéritos e Questionários
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Em] Mês de entrada:1608
[Cu] Atualização por classe:141206
[Lr] Data última revisão:
141206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141206
[St] Status:MEDLINE
[do] DOI:10.13109/prkk.2014.63.7.577


  9 / 3578 MEDLINE  
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[PMID]:25154691
[Au] Autor:Schaub N; Degen L
[Ad] Endereço:Abteilung für Gastroenterologie und Hepatologie, Universitätsspital Basel.
[Ti] Título:[Functional diarrhea - pathophysiology, investigation and treatment].
[Ti] Título:Funktionelle Diarrhoe - Pathophysiologie, Abklärung und Therapie..
[So] Source:Ther Umsch;71(9):551-8, 2014 Sep.
[Is] ISSN:0040-5930
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Ab] Resumo:The most important reason for functional diarrhea in clinical practice is diarrhea-predominant irritable bowel syndrome (IBS) which is characterized by chronic intermittent diarrhea and abdominal pain. The pathophysiology underlying IBS is complex and includes visceral hypersensitivity, abnormal gut motility and autonomous nervous system dysfunction as well as genetic and psychosocial factors. Treatment should be tailored to the individual's symptoms and involves general measures, pharmacological treatments, dietary interventions, psychotherapy and complementary and alternative approaches. The following manuscript will give an overview over pathophysiology, reasonable investigations and treatment of IBS.
[Mh] Termos MeSH primário: Doenças Funcionais do Colo/diagnóstico
Diarreia/etiologia
[Mh] Termos MeSH secundário: Encéfalo/fisiopatologia
Doenças Funcionais do Colo/fisiopatologia
Doenças Funcionais do Colo/terapia
Diagnóstico Diferencial
Diarreia/fisiopatologia
Diarreia/terapia
Sistema Nervoso Entérico/fisiopatologia
Motilidade Gastrointestinal/fisiologia
Seres Humanos
Intestinos/inervação
Síndrome do Intestino Irritável/diagnóstico
Síndrome do Intestino Irritável/fisiopatologia
Síndrome do Intestino Irritável/terapia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140826
[Lr] Data última revisão:
140826
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140827
[St] Status:MEDLINE
[do] DOI:10.1024/0040-5930/a000551


  10 / 3578 MEDLINE  
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[PMID]:24965903
[Au] Autor:Cremonini F
[Ad] Endereço:Division of Gastroenterology, Southern Nevada VA Healthcare System, Las Vegas, NV, USA; Las Vegas Gastroenterology and First Class Medicine, Las Vegas, NV, USA.
[Ti] Título:Standardized herbal treatments on functional bowel disorders: moving from putative mechanisms of action to controlled clinical trials.
[So] Source:Neurogastroenterol Motil;26(7):893-900, 2014 Jul.
[Is] ISSN:1365-2982
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Symptom relief in functional gastrointestinal disorders (FGID) is frequently sought with complementary and alternative medicine, and various herbal medicine compounds are popular in different parts of the world. Only a few products, however, are standardized and are backed by scientific evidence. This review mainly focuses on mechanistic and clinical data in support of the Japanese traditional compound Rikkunshi-to (RKT) and of STW-5. Their effects on gut sensori-motor function, neurohormonal network, and controlled clinical data in FGID are revised. RKT and STW-5 appear to possess some degree of gastroprokinetic, visceral analgesic properties, and seem to increase the gastric accommodation response. Controlled trials of RKT and STW-5 support at least a modest effect on symptoms of functional dyspepsia and irritable bowel syndrome, with low side effects profile. With the widespread use of herbals and the relative paucity of effective pharmacological options for FGID, rigorous studies to further elucidate pharmacological actions and clinical applications of herbal compounds are a priority.
[Mh] Termos MeSH primário: Doenças Funcionais do Colo/tratamento farmacológico
Medicamentos de Ervas Chinesas/uso terapêutico
Fármacos Gastrointestinais/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Fitoterapia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Gastrointestinal Agents)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140626
[Lr] Data última revisão:
140626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140627
[St] Status:MEDLINE
[do] DOI:10.1111/nmo.12384



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde