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| [PMID]: | 29112567 |
| [Au] Autor: | Cranston RD; Regueiro M; Hashash J; Baker JR; Richardson-Harman N; Janocko L; McGowan I |
| [Ad] Endereço: | 1 Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 2 Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 3 University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 4 Alpha StatConsult, Damascus, Maryland 5 Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. |
| [Ti] Título: | A Pilot Study of the Prevalence of Anal Human Papillomavirus and Dysplasia in a Cohort of Patients With IBD. |
| [So] Source: | Dis Colon Rectum;60(12):1307-1313, 2017 Dec. | | [Is] ISSN: | 1530-0358 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | BACKGROUND: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD. OBJECTIVE: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. DESIGN: Patients had an anal examination before routine colonoscopy. SETTINGS: The study was conducted at a tertiary IBD referral center. PATIENTS: We studied a convenience sample of sexually active male and female patients with IBD who were not on biological therapy. INTERVENTION: Anal examination, anal and vaginal human papillomavirus testing, anal cytology, and high-resolution anoscopy/biopsy were carried out. MAIN OUTCOME MEASURES: Anal and vaginal human papillomavirus types, anal cytology, and biopsy grade were measured. RESULTS: Twenty-five male and 21 female evaluable participants, 31 with Crohn's disease, 14 with ulcerative colitis, and 1 with indeterminate colitis, were predominantly white (91.3%), treatment experienced (76.1%), an average age of 38.1 years (range, 22.0-66.0 y), and had an average length of IBD diagnosis of 9.3 years (range, 1.0-33.0 y). Eighteen (39.1%) had an abnormal perianal examination and 3 (6.5%) had an abnormal digital examination. Forty-one (89.1%) had anal human papillomavirus, 16 with a single type and 25 with multiple types (range, 2-5 types). Human papillomavirus type 16 was most common (65.2%), followed by human papillomavirus types 11 and 45 (37.0% each). Nineteen of 21 (90.5%) women had vaginal human papillomavirus. Overall, 21 (45.7%) had abnormal anal cytology. Thirty three (71.7%) had ≥1 anal biopsy (9 had multiple), with dysplasia diagnosed in 28 (60.9%) and high-grade and low-grade squamous intraepithelial lesions diagnosed in 4 (8.7%) and 24 (43.5%). LIMITATIONS: No control group was included, and no detailed sexual history was taken. CONCLUSIONS: A high prevalence of anal and vaginal human papillomavirus and anal dysplasia was demonstrated in the study population outcomes. See Video Abstract at http://links.lww.com/DCR/A379. |
| [Mh] Termos MeSH primário: |
Doenças do Ânus/epidemiologia
Doenças do Ânus/virologia
Doenças Inflamatórias Intestinais/complicações
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/epidemiologia
Infecções por Papillomavirus/virologia
Lesões Pré-Cancerosas/epidemiologia
Lesões Pré-Cancerosas/virologia
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| [Mh] Termos MeSH secundário: |
Adulto
Idoso
Biópsia
Feminino
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Reação em Cadeia da Polimerase
Prevalência
Fatores de Risco
Vagina/virologia
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| [Pt] Tipo de publicação: | JOURNAL ARTICLE; VIDEO-AUDIO MEDIA |
| [Em] Mês de entrada: | 1711 |
| [Cu] Atualização por classe: | 171113 |
[Lr] Data última revisão:
| 171113 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 171108 |
| [St] Status: | MEDLINE |
| [do] DOI: | 10.1097/DCR.0000000000000878 |
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