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[PMID]:29095917
[Au] Autor:Parsons BN; Ijaz UZ; D'Amore R; Burkitt MD; Eccles R; Lenzi L; Duckworth CA; Moore AR; Tiszlavicz L; Varro A; Hall N; Pritchard DM
[Ad] Endereço:Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UNITED KINGDOM.
[Ti] Título:Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.
[So] Source:PLoS Pathog;13(11):e1006653, 2017 Nov.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each of these conditions was associated with specific alterations in the gastric microbiota and that this influenced subsequent tumour risk. 95 patients (in groups representing normal stomach, PPI treated, H. pylori gastritis, H. pylori-induced atrophic gastritis and autoimmune atrophic gastritis) were selected from a cohort of 1400. RNA extracted from gastric corpus biopsies was analysed using 16S rRNA sequencing (MiSeq). Samples from normal stomachs and patients treated with PPIs demonstrated similarly high microbial diversity. Patients with autoimmune atrophic gastritis also exhibited relatively high microbial diversity, but with samples dominated by Streptococcus. H. pylori colonisation was associated with decreased microbial diversity and reduced complexity of co-occurrence networks. H. pylori-induced atrophic gastritis resulted in lower bacterial abundances and diversity, whereas autoimmune atrophic gastritis resulted in greater bacterial abundance and equally high diversity compared to normal stomachs. Pathway analysis suggested that glucose-6-phospahte1-dehydrogenase and D-lactate dehydrogenase were over represented in H. pylori-induced atrophic gastritis versus autoimmune atrophic gastritis, and that both these groups showed increases in fumarate reductase. Autoimmune and H. pylori-induced atrophic gastritis were associated with different gastric microbial profiles. PPI treated patients showed relatively few alterations in the gastric microbiota compared to healthy subjects.
[Mh] Termos MeSH primário: Acloridria/microbiologia
Mucosa Gástrica/microbiologia
Microbioma Gastrointestinal
[Mh] Termos MeSH secundário: Acloridria/induzido quimicamente
Acloridria/etiologia
Acloridria/imunologia
Adulto
Idoso
Doenças Autoimunes/tratamento farmacológico
Doenças Autoimunes/imunologia
Doenças Autoimunes/microbiologia
Análise por Conglomerados
Estudos de Coortes
Inglaterra/epidemiologia
Feminino
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/imunologia
Gastrite Atrófica/tratamento farmacológico
Gastrite Atrófica/imunologia
Gastrite Atrófica/microbiologia
Microbioma Gastrointestinal/efeitos dos fármacos
Infecções por Helicobacter/tratamento farmacológico
Infecções por Helicobacter/imunologia
Infecções por Helicobacter/microbiologia
Helicobacter pylori/efeitos dos fármacos
Helicobacter pylori/crescimento & desenvolvimento
Helicobacter pylori/imunologia
Helicobacter pylori/isolamento & purificação
Hospitais Universitários
Seres Humanos
Masculino
Meia-Idade
Inibidores da Bomba de Prótons/efeitos adversos
Inibidores da Bomba de Prótons/uso terapêutico
Risco
Neoplasias Gástricas/epidemiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006653


  2 / 1025 MEDLINE  
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[PMID]:28886101
[Au] Autor:Kayamba V; Shibemba A; Zyambo K; Heimburger DC; Morgan DR; Kelly P
[Ad] Endereço:Tropical Gastroenterology & Nutrition group, Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
[Ti] Título:High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.
[So] Source:PLoS One;12(9):e0184272, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Confocal laser endomicroscopy (CLE) may increase the detection of gastric premalignant lesions, and facilitate targeted biopsies for histology. The study aim was to analyse premalignant lesions in Zambian adults using CLE. METHODS: Using CLE and histology we analysed the antral mucosa for gastric premalignant lesions in asymptomatic adults living with HIV and in HIV seronegative adults. Fasting gastric pH and the presence of Helicobacter pylori (H. pylori) were also evaluated. RESULTS: We enrolled 84 HIV seropositive participants (median age 43 years; 55 (65%) female), of whom 32 (38%) were anti-retroviral therapy (ART)-naïve. Also enrolled were 22 HIV seronegative controls (median age 39 years, 12 (55%) females). Hypochlorhydria was found in 48 (57%) HIV positive and 8 (38%) HIV negative controls (P = 0.14). Detection of gastric intestinal metaplasia (GIM) was higher (P = 0.007) using CLE (49, 54%) than histology (9, 9%) and, using CLE, GIM was similar between HIV positive (41, 60%) and negative groups (8, 36%; P = 0.08). Gastric luminal fluorescein leakage was significantly associated with the presence of GIM [OR 8.2; 95% CI 2.5-31, P<0.001]. CONCLUSION: CLE is useful for the detection of GIM, and luminal fluorescein leakage may represent a novel CLE marker for GIM. GIM is common in Zambian adults, and is highly prevalent irrespective of HIV infection or use of ART.
[Mh] Termos MeSH primário: Gastroenteropatias/epidemiologia
Gastroenteropatias/patologia
[Mh] Termos MeSH secundário: Acloridria/metabolismo
Adulto
Coinfecção
Endoscópios Gastrointestinais
Feminino
Mucosa Gástrica/metabolismo
Mucosa Gástrica/patologia
Gastrite Atrófica/complicações
Gastrite Atrófica/metabolismo
Gastrite Atrófica/patologia
Gastroenteropatias/diagnóstico
Infecções por HIV/complicações
Infecções por HIV/tratamento farmacológico
Infecções por HIV/virologia
Infecções por Helicobacter/complicações
Infecções por Helicobacter/microbiologia
Seres Humanos
Masculino
Metaplasia
Microscopia Confocal
Meia-Idade
Lesões Pré-Cancerosas/epidemiologia
Lesões Pré-Cancerosas/patologia
Prevalência
Neoplasias Gástricas/epidemiologia
Neoplasias Gástricas/etiologia
Neoplasias Gástricas/patologia
Adulto Jovem
Zâmbia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184272


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[PMID]:27810562
[Au] Autor:Kojo Y; Matsunaga S; Suzuki H; Sato H; Seto Y; Onoue S
[Ad] Endereço:Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
[Ti] Título:Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach.
[So] Source:Eur J Pharm Sci;97:55-61, 2017 Jan 15.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study was aimed to evaluate the applicability of a self-micellizing solid dispersion (SMSD) system of itraconazole (ITZ) with the use of Soluplus to achieve improved dissolution and stable oral absorption of ITZ under hypochlorhydric conditions. The SMSD of ITZ (SMSD/ITZ) was prepared by the freeze-drying method. Physicochemical properties of SMSD/ITZ were assessed in terms of morphology, crystallinity, particle size, thermal behavior, dissolution profile, and stability. The pharmacokinetic profile of SMSD/ITZ was evaluated in both normal rats and omeprazole-treated rats as a hypochlorhydric model. From the crystallinity assessment, ITZ in SMSD/ITZ might exist in an amorphous state. The dissolution behavior of SMSD/ITZ was markedly improved under both acidic and neutral conditions through the formation of nano-micelles with a diameter of 127nm. The degradation of ITZ in SMSD/ITZ was negligible after storage under accelerated conditions at 40°C or 40°C/75%RH for 4weeks. Under light exposure, ca. 33% of ITZ in SMSD/ITZ was degraded, suggesting the need for protection from light. Although the oral absorption of crystalline ITZ was negligible, SMSD/ITZ showed an improved pharmacokinetic profile in normal rats, with an absolute bioavailability (BA) of 2.9%, and even 6.3% in the hypochlorhydric model. From these findings, SMSD technology could be beneficial for improving the absorption profiles of weak basic drugs, even in hypochlorhydric patients.
[Mh] Termos MeSH primário: Acloridria/metabolismo
Antifúngicos/metabolismo
Absorção Intestinal/fisiologia
Itraconazol/metabolismo
Micelas
Polietilenoglicóis/metabolismo
Polivinil/metabolismo
[Mh] Termos MeSH secundário: Acloridria/tratamento farmacológico
Administração Oral
Animais
Antifúngicos/administração & dosagem
Antifúngicos/química
Linhagem Celular
Liberação Controlada de Fármacos/efeitos dos fármacos
Liberação Controlada de Fármacos/fisiologia
Absorção Intestinal/efeitos dos fármacos
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/metabolismo
Itraconazol/administração & dosagem
Itraconazol/química
Masculino
Polietilenoglicóis/administração & dosagem
Polietilenoglicóis/química
Polivinil/administração & dosagem
Polivinil/química
Ratos
Ratos Sprague-Dawley
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Micelles); 0 (Polyvinyls); 0 (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer); 304NUG5GF4 (Itraconazole); 30IQX730WE (Polyethylene Glycols)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


  4 / 1025 MEDLINE  
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[PMID]:27190191
[Au] Autor:Krishna U; Romero-Gallo J; Suarez G; Azah A; Krezel AM; Varga MG; Forsyth MH; Peek RM
[Ad] Endereço:Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition.
[Ti] Título:Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease.
[So] Source:J Infect Dis;214(4):644-8, 2016 Aug 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Helicobacter pylori is the strongest risk factor for gastric adenocarcinoma, which develops within a hypochlorhydric environment. We sequentially isolated H. pylori (strain J99) from a patient who developed corpus-predominant gastritis and hypochlorhydia over a 6-year interval. Archival J99 survived significantly better under acidic conditions than recent J99 strains. H. pylori arsRS encodes a 2-component system critical for stress responses; recent J99 isolates harbored 2 nonsynonymous arsS mutations, and arsS inactivation abolished acid survival. In vivo, acid-resistant archival, but not recent J99, successfully colonized high-acid-secreting rodents. Thus, genetic evolution of arsS may influence progression to hypochlorhydia and gastric cancer.
[Mh] Termos MeSH primário: Acloridria/microbiologia
Evolução Molecular
Gastrite/microbiologia
Infecções por Helicobacter/microbiologia
Helicobacter pylori/enzimologia
Helicobacter pylori/genética
Histidina Quinase/genética
[Mh] Termos MeSH secundário: Ácidos/toxicidade
Animais
Proteínas de Bactérias/genética
Gastrite/complicações
Gerbillinae
Helicobacter pylori/isolamento & purificação
Helicobacter pylori/fisiologia
Seres Humanos
Masculino
Camundongos Endogâmicos C57BL
Viabilidade Microbiana/efeitos dos fármacos
Mutação de Sentido Incorreto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids); 0 (Bacterial Proteins); EC 2.7.13.1 (Histidine Kinase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160519
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jiw189


  5 / 1025 MEDLINE  
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[PMID]:26975361
[Au] Autor:Litou C; Vertzoni M; Goumas C; Vasdekis V; Xu W; Kesisoglou F; Reppas C
[Ad] Endereço:Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Panepistimiopolis, 157 71, Zografou, Greece.
[Ti] Título:Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug - Drug Interaction Studies.
[So] Source:Pharm Res;33(6):1399-412, 2016 06.
[Is] ISSN:1573-904X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Evaluate the impact of reduced gastric acid secretion after administration of two acid-reducing agents on the physicochemical characteristics of contents of upper gastrointestinal lumen of fasted adults. MATERIALS AND METHODS: Eight healthy male adults, fasted from food for 12 h, participated in a three-phase crossover study. Phase 1: No drug treatment prior to aspirations. Phase 2: Oral administration of 40 mg pantoprazole at ~9 am the last 3 days prior to aspirations and at ~7 am on aspiration day. Phase 3: Oral administration of 20 mg famotidine at ~7 pm prior to aspirations and at ~7 am on aspiration day. Samples from the contents of upper gastrointestinal lumen were aspirated for 50 min, after administration of 240 ml table water at ~9 am. RESULTS: Reduction of gastric acid secretion was accompanied by reduced buffer capacity, chloride ion concentration, osmolality and surface tension in stomach and by increased pH (up to ~0.7 units) in upper small intestine during the first 50 min post-water administration. The mechanism of reduction of acid secretion seems to be important for the buffer capacity in stomach and for the surface tension in upper gastrointestinal lumen. CONCLUSIONS: Apart from gastric pH, reduced acid secretion affects physicochemical characteristics of contents of upper gastrointestinal lumen which may be important for the performance of certain drugs/products in the fasted state.
[Mh] Termos MeSH primário: 2-Piridinilmetilsulfinilbenzimidazóis/efeitos adversos
Acloridria/induzido quimicamente
Famotidina/efeitos adversos
Jejum/metabolismo
Ácido Gástrico/secreção
Mucosa Gástrica/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos H2/efeitos adversos
Inibidores da Bomba de Prótons/efeitos adversos
[Mh] Termos MeSH secundário: 2-Piridinilmetilsulfinilbenzimidazóis/administração & dosagem
Acloridria/metabolismo
Administração Oral
Adulto
Ácidos e Sais Biliares/metabolismo
Tampões (Química)
Cloretos/metabolismo
Estudos Cross-Over
Ingestão de Líquidos
Esquema de Medicação
Interações Medicamentosas
Famotidina/administração & dosagem
Mucosa Gástrica/metabolismo
Mucosa Gástrica/secreção
Conteúdo Gastrointestinal/química
Grécia
Voluntários Saudáveis
Antagonistas dos Receptores Histamínicos H2/administração & dosagem
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Concentração Osmolar
Inibidores da Bomba de Prótons/administração & dosagem
Sucção
Tensão Superficial
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-Pyridinylmethylsulfinylbenzimidazoles); 0 (Bile Acids and Salts); 0 (Buffers); 0 (Chlorides); 0 (Histamine H2 Antagonists); 0 (Proton Pump Inhibitors); 5QZO15J2Z8 (Famotidine); D8TST4O562 (pantoprazole)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE
[do] DOI:10.1007/s11095-016-1882-8


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[PMID]:26945509
[Au] Autor:Haffner-Luntzer M; Heilmann A; Heidler V; Liedert A; Schinke T; Amling M; Yorgan TA; Vom Scheidt A; Ignatius A
[Ad] Endereço:Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, Helmholtzstraße 14, Ulm, 89081, Germany.
[Ti] Título:Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.
[So] Source:J Orthop Res;34(11):1914-1921, 2016 Nov.
[Is] ISSN:1554-527X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Efficient calcium absorption is essential for skeletal health. Patients with impaired gastric acidification display low bone mass and increased fracture risk because calcium absorption is dependent on gastric pH. We investigated fracture healing and post-traumatic bone turnover in mice deficient in Cckbr, encoding a gastrin receptor that affects acid secretion by parietal cells. Cckbr-/- mice display hypochlorhydria, calcium malabsorption, and osteopenia. Cckbr-/- and wildtype (WT) mice received a femur osteotomy and were fed either a standard or calcium-enriched diet. Healed and intact bones were assessed by biomechanical testing, histomorphometry, micro-computed tomography, and quantitative backscattering. Parathyroid hormone (PTH) serum levels were determined by enzyme-linked immunosorbent assay. Fracture healing was unaffected in Cckbr-/- mice. However, Cckbr-/- mice displayed increased calcium mobilization from the intact skeleton during bone healing, confirmed by significantly elevated PTH levels and osteoclast numbers compared to WT mice. Calcium supplementation significantly reduced secondary hyperparathyroidism and bone resorption in the intact skeleton in both genotypes, but more efficiently in WT mice. Furthermore, calcium administration improved bone healing in WT mice, indicated by significantly increased mechanical properties and bone mineral density of the fracture callus, whereas it had no significant effect in Cckbr-/- mice. Therefore, under conditions of hypochlorhydria-induced calcium malabsorption, calcium, which is essential for callus mineralization, appears to be increasingly mobilized from the intact skeleton in favor of fracture healing. Calcium supplementation during fracture healing prevented systemic calcium mobilization, thereby maintaining bone mass and improving fracture healing in healthy individuals whereas the effect was limited by gastric hypochlorhydria. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1914-1921, 2016.
[Mh] Termos MeSH primário: Acloridria/complicações
Reabsorção Óssea/etiologia
Distúrbios do Metabolismo do Cálcio/fisiopatologia
Fraturas do Fêmur/complicações
Consolidação da Fratura
[Mh] Termos MeSH secundário: Animais
Cálcio/metabolismo
Cálcio/uso terapêutico
Distúrbios do Metabolismo do Cálcio/complicações
Suplementos Nutricionais
Feminino
Fraturas do Fêmur/metabolismo
Camundongos
Distribuição Aleatória
Receptor de Colecistocinina B/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Receptor, Cholecystokinin B); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160307
[St] Status:MEDLINE
[do] DOI:10.1002/jor.23221


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[PMID]:26329936
[Au] Autor:Yoshida S; Yamamoto H; Tetsui T; Kobayakawa Y; Hatano R; Mukaisho K; Hattori T; Sugihara H; Asano S
[Ad] Endereço:Department of Molecular Physiology, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga, 525-8577, Japan.
[Ti] Título:Effects of ezrin knockdown on the structure of gastric glandular epithelia.
[So] Source:J Physiol Sci;66(1):53-65, 2016 Jan.
[Is] ISSN:1880-6562
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Ezrin, an adaptor protein that cross-links plasma membrane-associated proteins with the actin cytoskeleton, is concentrated on apical surfaces of epithelial cells, especially in microvilli of the small intestine and stomach. In the stomach, ezrin is predominantly expressed on the apical canalicular membrane of parietal cells. Transgenic ezrin knockdown mice in which the expression level of ezrin was reduced to <7% compared with the wild-type suffered from achlorhydria because of impairment of membrane fusion between tubulovesicles and apical membranes. We observed, for the first time, hypergastrinemia and foveolar hyperplasia in the gastric fundic region of the knockdown mice. Dilation of fundic glands was observed, the percentage of parietal and chief cells was reduced, and that of mucous-secreting cells was increased. The parietal cells of knockdown mice contained dilated tubulovesicles and abnormal mitochondria, and subsets of these cells contained abnormal vacuoles and multilamellar structures. Therefore, lack of ezrin not only causes achlorhydria and hypergastrinemia but also changes the structure of gastric glands, with severe perturbation of the secretory membranes of parietal cells.
[Mh] Termos MeSH primário: Proteínas do Citoesqueleto/metabolismo
Epitélio/fisiologia
Mucosa Gástrica/fisiologia
Regulação da Expressão Gênica/fisiologia
Células Parietais Gástricas/metabolismo
[Mh] Termos MeSH secundário: Acloridria/metabolismo
Animais
Anticorpos
Proteínas do Citoesqueleto/genética
Mucosa Gástrica/citologia
Gastrinas/sangue
Técnicas de Silenciamento de Genes
Lectinas
Camundongos
Camundongos Transgênicos
Microscopia de Fluorescência
Mucina-6/genética
Mucina-6/metabolismo
Mucinas/genética
Mucinas/metabolismo
Proteínas Musculares/genética
Proteínas Musculares/metabolismo
Células Parietais Gástricas/ultraestrutura
Peptídeos/genética
Peptídeos/metabolismo
RNA/genética
RNA/metabolismo
Fator Trefoil-2
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies); 0 (Cytoskeletal Proteins); 0 (Gastrins); 0 (Lectins); 0 (Muc6 protein, mouse); 0 (Mucin-6); 0 (Mucins); 0 (Muscle Proteins); 0 (Peptides); 0 (TFF2 protein, mouse); 0 (Trefoil Factor-2); 0 (ezrin); 63231-63-0 (RNA)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150903
[St] Status:MEDLINE
[do] DOI:10.1007/s12576-015-0393-4


  8 / 1025 MEDLINE  
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[PMID]:26211930
[Au] Autor:Serrano CA; Villagrán A; Toledo H; Crabtree JE; Harris PR
[Ad] Endereço:Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
[Ti] Título:Iron Deficiency and IL1ß Polymorphisms in Helicobacter pylori-infected Children.
[So] Source:Helicobacter;21(2):124-30, 2016 Apr.
[Is] ISSN:1523-5378
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Helicobacter pylori infection has been associated with an imbalance of iron homeostasis. IL-1ß has been related with iron absorption disturbances through a variety of mechanisms. The aim of this study was to evaluate the presence of polymorphic variants for IL-1ß cluster and gastric IL1ß mRNA expression in H. pylori-infected children and their relationship with hypochlorhydria and iron deficiency (ID). PATIENTS AND METHODS: Prospective study of 123 symptomatic children. At endoscopy, antral biopsies were taken for urease test, pathology and culture and blood for analysis of ferritin, transferrin, serum iron, and total iron-binding capacity. Polymorphisms in the IL-1ß cluster (positions -511, -31, +3954, ILRN) were determined by PCR-RFLP. Gastric mucosal expression of IL-1ß mRNA was determined by RT-PCR. RESULTS: After exclusions, of 105 patients, 33 (31.4%) were H. pylori positive. Nine (8.6%) children were classified as iron deficient (ID). Helicobacter pylori positivity was associated with ID (OR: 5.1; 95% CI: 1.2-21.9) (p = .04). No significant differences were found in allele frequency for IL1ß gene cluster polymorphisms between infected and uninfected children. Helicobacter pylori-infected children with ID had significantly increased gastric IL1ß mRNA in comparison with infected children without ID. In addition, a significant positive correlation was observed between mucosal IL-1ß mRNA and fasting gastric juice pH. Gastric pH values were significantly increased in H. pylori-infected patients with ID compared to uninfected children. CONCLUSIONS: The established association between H. pylori infection and ID in children may be mediated by increased gastric mucosal IL-1ß.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica
Infecções por Helicobacter/complicações
Interleucina-1beta/biossíntese
Interleucina-1beta/genética
Ferro/deficiência
Polimorfismo Genético
[Mh] Termos MeSH secundário: Acloridria/epidemiologia
Adolescente
Biópsia
Criança
Endoscopia Gastrointestinal
Feminino
Mucosa Gástrica/patologia
Seres Humanos
Concentração de Íons de Hidrogênio
Masculino
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
Estudos Prospectivos
RNA Mensageiro/análise
RNA Mensageiro/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (RNA, Messenger); E1UOL152H7 (Iron)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE
[do] DOI:10.1111/hel.12247


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[PMID]:26628571
[Au] Autor:Betesh AL; Santa Ana CA; Cole JA; Fordtran JS
[Ad] Endereço:From the Department of Internal Medicine, Baylor University Medical Center, Dallas, TX (e-mail: johnfo@baylorhealth.edu).
[Ti] Título:Reply to R Schiffmann.
[So] Source:Am J Clin Nutr;102(6):1615-6, 2015 Dec.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Acloridria/sangue
Anemia Ferropriva/sangue
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151202
[Lr] Data última revisão:
151202
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.120576


  10 / 1025 MEDLINE  
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[PMID]:26628570
[Au] Autor:Schiffmann R
[Ad] Endereço:From the Institute of Metabolic Disease, Baylor Research Institute, Dallas, TX (e-mail: raphael.schiffmann@baylorhealth.edu).
[Ti] Título:A genetic form of achlorhydria and gastritis.
[So] Source:Am J Clin Nutr;102(6):1615, 2015 Dec.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Acloridria/sangue
Anemia Ferropriva/sangue
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151202
[Lr] Data última revisão:
151202
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151203
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.120550



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