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[PMID]:29072876
[Au] Autor:Dyggve H; Jarva H; Spillmann T; Speeti M; Meri S
[Ad] Endereço:Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
[Ti] Título:Identification of Glyceraldehyde-3-Phosphate and Alcohol Dehydrogenases as Autoantigens in Doberman Hepatitis.
[So] Source:Scand J Immunol;86(3):156-164, 2017 Sep.
[Is] ISSN:1365-3083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An autoimmune background is suspected for Doberman hepatitis (DH). It is based on the finding of mononuclear cell infiltrates in the liver, strong female bias, association to the homozygous risk factor dog leucocyte antigen (DLA) allele DRB1*00601 and aberrant major histocompatibility complex (MHC) class II expression on hepatocytes that correlates with the degree of inflammation in the liver. The aim of this study was to search for autoantibodies against liver-related antigens associated with DH. Twenty-five Dobermans with subclinical DH (SDH), 13 that clinically manifest DH (CDH) and 17 healthy controls were studied. Immunoblotting analysis detected specific antibodies in the DH sera. By mass spectrometry the targets were identified as liver-related enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and alcohol dehydrogenase (ADH). Using ELISA, anti-GAPDH IgG was detected in 36% (9/25) of SDH dogs and 69.2% (9/13) of the CDH dogs compared to healthy controls (0/17) (P < 0.0005). Anti-ADH IgG was detected in 72% (18/25) of SDH dogs and 76.9% (10/13) of CDH dogs and only in one (1/17) control (P < 0.0005). The finding of novel autoantigens, GAPDH and ADH strengthen the hypothesis that DH is an autoimmune disease of the liver. These findings suggest that DH could be diagnosed by screening for autoantibodies against the defined antigens.
[Mh] Termos MeSH primário: Álcool Desidrogenase/imunologia
Gliceraldeído 3-Fosfato/imunologia
Hepatite Animal/imunologia
[Mh] Termos MeSH secundário: Animais
Autoanticorpos/sangue
Autoanticorpos/imunologia
Autoantígenos/imunologia
Cães
Ensaio de Imunoadsorção Enzimática
Feminino
Hepatite Animal/metabolismo
Hepatite Animal/patologia
Immunoblotting
Masculino
Proteoma
Proteômica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 0 (Autoantigens); 0 (Proteome); 142-10-9 (Glyceraldehyde 3-Phosphate); EC 1.1.1.1 (Alcohol Dehydrogenase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1111/sji.12575


  2 / 1345 MEDLINE  
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[PMID]:28715128
[Au] Autor:Le Cann F; Delehouzé C; Leverrier-Penna S; Filliol A; Comte A; Delalande O; Desban N; Baratte B; Gallais I; Piquet-Pellorce C; Faurez F; Bonnet M; Mettey Y; Goekjian P; Samson M; Vandenabeele P; Bach S; Dimanche-Boitrel MT
[Ad] Endereço:INSERM UMR 1085, l'Environnement et le Travail, Institut de Recherche sur la Santé, Rennes, France.
[Ti] Título:Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis.
[So] Source:FEBS J;284(18):3050-3068, 2017 Sep.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Necroptosis is a regulated form of cell death involved in several disease models including in particular liver diseases. Receptor-interacting protein kinases, RIPK1 and RIPK3, are the main serine/threonine kinases driving this cell death pathway. We screened a noncommercial, kinase-focused chemical library which allowed us to identify Sibiriline as a new inhibitor of necroptosis induced by tumor necrosis factor (TNF) in Fas-associated protein with death domain (FADD)-deficient Jurkat cells. Moreover, Sib inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis. By using competition binding assay and recombinant kinase assays, we demonstrated that Sib is a rather specific competitive RIPK1 inhibitor. Molecular docking analysis shows that Sib is trapped closed to human RIPK1 adenosine triphosphate-binding site in a relatively hydrophobic pocket locking RIPK1 in an inactive conformation. In agreement with its RIPK1 inhibitory property, Sib inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis. Finally, Sib protects mice from concanavalin A-induced hepatitis. These results reveal the small-molecule Sib as a new RIPK1 inhibitor potentially of interest for the treatment of immune-dependent hepatitis.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Hepatite Animal/prevenção & controle
Fatores Imunológicos/farmacologia
Inibidores de Proteínas Quinases/farmacologia
Proteína Serina-Treonina Quinases de Interação com Receptores/genética
Compostos de Espiro/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Animais
Apoptose/efeitos dos fármacos
Apoptose/genética
Caspase 3/genética
Caspase 3/imunologia
Linhagem Celular Transformada
Concanavalina A
Cicloeximida/farmacologia
Fibroblastos/citologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Regulação da Expressão Gênica
Células HT29
Hepatite Animal/induzido quimicamente
Hepatite Animal/genética
Hepatite Animal/imunologia
Seres Humanos
Imidazóis/farmacologia
Fatores Imunológicos/química
Indóis/farmacologia
Células Jurkat
Masculino
Camundongos
Simulação de Acoplamento Molecular
Necrose/induzido quimicamente
Necrose/genética
Necrose/imunologia
Inibidores de Proteínas Quinases/química
Proteína Serina-Treonina Quinases de Interação com Receptores/antagonistas & inibidores
Proteína Serina-Treonina Quinases de Interação com Receptores/imunologia
Transdução de Sinais
Compostos de Espiro/química
Ligante Indutor de Apoptose Relacionado a TNF/farmacologia
Fator de Necrose Tumoral alfa/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Imidazoles); 0 (Immunologic Factors); 0 (Indoles); 0 (Protein Kinase Inhibitors); 0 (Spiro Compounds); 0 (TNF-Related Apoptosis-Inducing Ligand); 0 (TNFSF10 protein, human); 0 (Tumor Necrosis Factor-alpha); 0 (necrostatin-1); 0 (sibirine); 11028-71-0 (Concanavalin A); 98600C0908 (Cycloheximide); EC 2.7.11.1 (RIPK1 protein, human); EC 2.7.11.1 (RIPK3 protein, human); EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1111/febs.14176


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[PMID]:28382699
[Au] Autor:Morishita K; Hiramoto A; Michishita A; Takagi S; Osuga T; Lim SY; Nakamura K; Sasaki N; Ohta H; Takiguchi M
[Ad] Endereço:Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
[Ti] Título:Washout Ratio in the Hepatic Vein Measured by Contrast-Enhanced Ultrasonography to Distinguish Between Inflammatory and Noninflammatory Hepatic Disorders in Dogs.
[So] Source:J Vet Intern Med;31(3):770-777, 2017 May.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Perflubutane microbubbles, a second-generation ultrasound contrast agent, are phagocytized by Kupffer cells. This characteristic may be useful to differentiate diffuse hepatic diseases in dogs. HYPOTHESIS/OBJECTIVES: To determine whether the washout ratio in the hepatic vein (HV) measured by contrast-enhanced ultrasonography (CEUS) can distinguish between inflammatory and noninflammatory hepatic disorders in dogs. ANIMALS: Forty-one client-owned dogs with hepatic disorders including 14 with hepatitis, 7 with primary hypoplasia of the portal vein (PHPV), 9 with congenital portosystemic shunt (cPSS), and 11 with other hepatopathy were enrolled. Six dogs without hepatic disease also were evaluated as healthy controls. METHODS: Dogs with hepatic disorders were prospectively included. Contrast-enhanced ultrasonography of the HV was performed for 2 minutes. Washout ratio was defined as the attenuation rate from peak intensity to the intensity at the end of the CEUS study. RESULTS: Washout ratio in the hepatitis group (median, 18.0%; range, 2.0-37.0%) was significantly lower than that of the PHPV (median, 52.2%; range, 11.5-86.3%), cPSS (median, 60.0%; range, 28.6-77.4%), other hepatopathy (median, 70.5%; range, 26.6-88.4%), and normal (median, 78.0%; range, 60.7-91.7%) groups. The area under the receiver operating characteristic curve for hepatitis was 0.960, with a 95% confidence interval (CI) of 0.853-0.990. Washout ratio ≤37.1% resulted in a sensitivity of 100% (95% CI, 78.5-100%) and specificity of 85.2% (95% CI, 67.5-94.1%) for the prediction of hepatitis. CONCLUSIONS AND CLINICAL IMPORTANCE: Washout ratio can distinguish hepatitis from the other noninflammatory disorders with high accuracy. This result might reflect impaired Kupffer cell phagocytosis in dogs with hepatitis.
[Mh] Termos MeSH primário: Meios de Contraste/administração & dosagem
Doenças do Cão/fisiopatologia
Veias Hepáticas/diagnóstico por imagem
Hepatite Animal/fisiopatologia
Inflamação/veterinária
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Cães
Feminino
Hepatite Animal/complicações
Hepatite Animal/diagnóstico por imagem
Inflamação/complicações
Inflamação/diagnóstico por imagem
Inflamação/fisiopatologia
Masculino
Estudos Prospectivos
Índice de Gravidade de Doença
Ultrassonografia/veterinária
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.14685


  4 / 1345 MEDLINE  
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[PMID]:28295598
[Au] Autor:Lidbury JA; Rodrigues Hoffmann A; Ivanek R; Cullen JM; Porter BF; Oliveira F; Van Winkle TJ; Grinwis GC; Sucholdolski JS; Steiner JM
[Ad] Endereço:Gastrointestinal Laboratory, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX.
[Ti] Título:Interobserver Agreement Using Histological Scoring of the Canine Liver.
[So] Source:J Vet Intern Med;31(3):778-783, 2017 May.
[Is] ISSN:1939-1676
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Grading schemes for the assessment of hepatic fibrosis and necroinflammatory activity in humans previously have been applied to dogs with chronic hepatitis. Interobserver agreement is a desirable characteristic for any histological scoring scheme. HYPOTHESIS/OBJECTIVES: To assess interobserver agreement associated with pathologists using a previously published histological scoring scheme to assess hepatic fibrosis and necroinflammatory activity in dogs and to compare fibrosis scores assigned to serial sections stained with hematoxylin & eosin (H&E) and picrosirius red. ANIMALS: Histological sections of liver from 50 dogs with variable degrees of hepatic fibrosis and necroinflammatory activity were selected from institutional tissue archives. METHODS: Six board-certified veterinary anatomic pathologists assigned fibrosis and necroinflammatory activity scores to the histological sections. The multiuser kappa statistic was calculated to assess interobserver agreement. Fibrosis stage assigned to serial sections stained with picrosirius red and H&E was compared using the Wilcoxon signed-rank test. RESULTS: Multiuser kappa statistics for assessment of fibrosis and necroinflammatory activity from H&E-stained sections were 0.35 and 0.16, respectively. There was no difference in median fibrosis scores assigned to serial section stained with H&E and picrosirius red (P = .248). CONCLUSIONS AND CLINICAL IMPORTANCE: There was fair interobserver agreement when pathologists assessed fibrosis and poor agreement when they assessed necroinflammatory activity. This suboptimal agreement must be taken into account by clinicians making decisions based on histology reports of the liver and in the design of studies evaluating these findings. To decrease this variability, ideally >1 pathologist should evaluate each section.
[Mh] Termos MeSH primário: Doenças do Cão/patologia
Fígado/patologia
Variações Dependentes do Observador
[Mh] Termos MeSH secundário: Animais
Cães
Fibrose
Hepatite Animal/patologia
Seres Humanos
Patologia Veterinária/normas
Patologia Veterinária/estatística & dados numéricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.1111/jvim.14684


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[PMID]:28246418
[Au] Autor:Davies JL; Uzal FA; Whitehead AE
[Ad] Endereço:Diagnostic Services Unit (Davies) and Department of Veterinary Clinical and Diagnostic Sciences (Whitehead), University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3; California Animal Health and Food Safety Laboratory, Faculty of Veterinary Medicine, University of California-Davis, 105 West Central Avenue, San Bernardino, California 92408, USA (Uzal).
[Ti] Título:Necrotizing hepatitis associated with in a pony in western Canada.
[So] Source:Can Vet J;58(3):285-288, 2017 Mar.
[Is] ISSN:0008-5286
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Severe icterus, peritoneal effusion, localized fibrinous peritonitis, and necrotizing hepatitis were found at necropsy of a 20-year-old female pony with a history of acute onset depression, inappetence, fever, and marked elevation in hepatic enzymes. Gross pathology, histopathology, and immunohistochemistry were compatible with a diagnosis of clostridial hepatitis caused by -group bacteria. This is believed to be the first reported case of clostridial hepatitis in an equid in Canada, and only the third report of this rare disease in North America.
[Mh] Termos MeSH primário: Infecções por Clostridium/veterinária
Clostridium/isolamento & purificação
Hepatite Animal/microbiologia
Doenças dos Cavalos/microbiologia
[Mh] Termos MeSH secundário: Animais
Canadá/epidemiologia
Infecções por Clostridium/epidemiologia
Infecções por Clostridium/patologia
Feminino
Hepatite Animal/epidemiologia
Cavalos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


  6 / 1345 MEDLINE  
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[PMID]:28215870
[Au] Autor:Calero-Bernal R; Mauroo NF; Hui SW; Kuiken T; van de Bildt MW; de Jong AW; Osterhaus AD; Sims L; Gendron-Fitzpatrick A; Carmena D; Cerqueira-Cézar CK; Rosenthal BM; Dubey JP
[Ad] Endereço:United States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Building 1001, Beltsville, MD 20705-2350, USA.
[Ti] Título:Acute fatal sarcocystosis hepatitis in an Indo-Pacific bottlenose dolphin (Tursiops aduncus) in Hong Kong.
[So] Source:Vet Parasitol;235:64-68, 2017 Feb 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Unlike most species in the genus Sarcocystis, Sarcocystis canis has a broad intermediate host range. Its life cycle is incompletely known and most reports are from the USA. Here we report fatal hepatitis in a 4year old male Indo-Pacific bottlenose dolphin (Tursiops aduncus) from Hong Kong associated with a S. canis-like infection. Diagnosis was made based on clinical presentation, histopathology, transmission electron microscopy (TEM), and molecular characterization. Microscopically, S. canis-like like infection was confined to the liver. Immature and mature schizonts were found in hepatocytes and the parasite was associated with generalized hepatic necrosis. By TEM, schizonts divided by endopolygeny, and merozoites lacked rhoptries. Molecular characterization of parasites present in liver and brain tissues at the cox1 gene showed a high degree of identity (97-98%) and clustered together with Sarcocystis canis, S. lutrae, S. arctica, S. speeri, S. turdusi, and S. rileyi in a phylogenetic study. This is the first report of S. canis-like infection from Asia.
[Mh] Termos MeSH primário: Golfinho Nariz-de-Garrafa/parasitologia
Hepatite Animal/parasitologia
Sarcocystis/isolamento & purificação
Sarcocistose/veterinária
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Evolução Fatal
Hepatite Animal/diagnóstico
Hong Kong
Fígado/parasitologia
Fígado/patologia
Fígado/ultraestrutura
Masculino
Filogenia
Polimorfismo de Nucleotídeo Único/genética
Sarcocystis/classificação
Sarcocystis/genética
Sarcocystis/ultraestrutura
Sarcocistose/diagnóstico
Sarcocistose/parasitologia
Esquizontes
Análise de Sequência de DNA/veterinária
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28160143
[Au] Autor:Niczyporuk JS
[Ad] Endereço:Department of Poultry Viral Disease, National Veterinary Research Institute, Partyzantów 57 Avenue, 24-100, Pulawy, Poland. jowita.niczyporuk@piwet.pulawy.pl.
[Ti] Título:Molecular characterisation of fowl adenovirus type 7 isolated from poultry associated with inclusion body hepatitis in Poland.
[So] Source:Arch Virol;162(5):1325-1333, 2017 May.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The fowl adenovirus field strain FAdV-JSN-5/10j (GenBank accession number KP879219) was isolated from the intestine of a 7-week-old chicken diagnosed with inclusion body hepatitis and simultaneously with Marek's disease, and for that reason, it was chosen for molecular study. It was identified as fowl adenovirus genotype 7 (species Fowl aviadenovirus E) based on nucleotide sequence analysis of the loop L1 region of the hexon gene. Nucleotide sequence alignment of this strain, FAdV-7 reference strains B-3A ATCC VR-832 (AF339922) and YR36 (AF508955), and eight additional FAdV-7 field strains confirmed its classification as FAdV-JS-5/10j and showed that these viruses are very similar to each other. Additionally, we described mutations and their influence on the amino acid sequence, nucleotide composition, and relative synonymous codon usage. Immunofluorescence of cell cultures infected with 10 TCID per 0.1-ml dose of the FAdV-JSN-5/10j strain demonstrated the presence of a cytopathic effect. Infection of fowl with adenoviruses raises concerns for poultry production, and thus, the efficient detection of adenovirus infection is crucial. This is the first attempt to describe the molecular characteristics of FadV-7 strains isolated in Poland.
[Mh] Termos MeSH primário: Aviadenovirus/classificação
Aviadenovirus/genética
Galinhas/virologia
DNA Viral/genética
Hepatite Animal/virologia
Doença de Marek/virologia
Doenças das Aves Domésticas/virologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos/genética
Animais
Aviadenovirus/isolamento & purificação
Composição de Bases/genética
Sequência de Bases
Embrião de Galinha
Polônia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Viral)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3240-5


  8 / 1345 MEDLINE  
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[PMID]:28088700
[Au] Autor:Yuan Y; Gong X; Zhang L; Jiang R; Yang J; Wang B; Wan J
[Ad] Endereço:Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.
[Ti] Título:Chlorogenic acid ameliorated concanavalin A-induced hepatitis by suppression of Toll-like receptor 4 signaling in mice.
[So] Source:Int Immunopharmacol;44:97-104, 2017 Mar.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chlorogenic acid (CGA), one of the most abundant dietary polyphenolic compounds, has been reported to exhibit anti-inflammatory ability. However, the hepatoprotective effects and molecular mechanisms of CGA on concanavalin A (Con A)-induced hepatitis have not been explored. In the present study, we found that pretreatment with CGA dose-dependently inhibited the elevation of plasma aminotransferases and alleviated hepatic pathological damage as well as hepatocyte apoptosis in Con A-exposed mice. Additionally, CGA markedly suppressed the production of serum tumor necrosis factor (TNF)-α and interferon (IFN)-γ, alleviated the infiltration of hepatic macrophages, neutrophils, and activated CD4 T lymphocytes in Con A-primed mice. Moreover, CGA downregulated Con A-induced hepatic expression of adhesion molecules (ICAM-1, VCAM-1 and ELAM-1) mRNA and protein, and inhibited Con A-activated Toll-like receptor (TLR) 4 signal molecules including TLR4, p-IRAK1, p-IκB, and p-p38. Finally, our results also showed that CGA exhibited a therapeutic effect, which CGA posttreatment improved hepatic damage at 1, 3, and 6h after Con A. Taken together, these data suggested that CGA could effectively prevent mice from Con A-induced hepatitis, which might be through suppressing the activation of TLR4 signaling, downregulating the expression of adhesion molecules, and alleviating the infiltration and activation of hepatic leukocytes and the production of pro-inflammatory cytokines.
[Mh] Termos MeSH primário: Linfócitos T CD4-Positivos/efeitos dos fármacos
Ácido Clorogênico/uso terapêutico
Hepatite Animal/tratamento farmacológico
Macrófagos do Fígado/efeitos dos fármacos
Fígado/efeitos dos fármacos
Receptor 4 Toll-Like/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Linfócitos T CD4-Positivos/imunologia
Adesão Celular
Concanavalina A/imunologia
Hepatite Animal/imunologia
Seres Humanos
Interferon gama/metabolismo
Macrófagos do Fígado/imunologia
Fígado/imunologia
Fígado/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/metabolismo
Transdução de Sinais/efeitos dos fármacos
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 0 (Tumor Necrosis Factor-alpha); 11028-71-0 (Concanavalin A); 318ADP12RI (Chlorogenic Acid); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170116
[St] Status:MEDLINE


  9 / 1345 MEDLINE  
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[PMID]:28063746
[Au] Autor:Bexfield N
[Ad] Endereço:School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, School Road, Leicestershire LE12 5RD, UK. Electronic address: nick.bexfield@nottingham.ac.uk.
[Ti] Título:Canine Idiopathic Chronic Hepatitis.
[So] Source:Vet Clin North Am Small Anim Pract;47(3):645-663, 2017 May.
[Is] ISSN:1878-1306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The World Small Animal Veterinary Association's Liver Standardization Group produced standardized criteria for the histologic diagnosis of canine chronic hepatitis (CH). They define CH by the presence of hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration, and fibrosis. There are variations in histologic appearance between breeds. Hepatic copper accumulation is an important cause of canine CH. However, where copper accumulation has been ruled out, dogs are said to have idiopathic CH. This article reviews theories regarding the etiopathogenesis of canine CH other than copper accumulation, and its clinical features, diagnostic findings, and management.
[Mh] Termos MeSH primário: Doenças do Cão
Hepatite Animal
Hepatite Crônica/veterinária
[Mh] Termos MeSH secundário: Animais
Antifibrinolíticos/uso terapêutico
Dietoterapia/veterinária
Doenças do Cão/diagnóstico
Doenças do Cão/etiologia
Doenças do Cão/fisiopatologia
Doenças do Cão/terapia
Cães
Feminino
Hepatite Animal/diagnóstico
Hepatite Animal/etiologia
Hepatite Animal/fisiopatologia
Hepatite Animal/terapia
Hepatite Crônica/etiologia
Hepatite Crônica/fisiopatologia
Hepatite Crônica/terapia
Masculino
Prognóstico
Fatores de Risco
Ácido Ursodesoxicólico/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antifibrinolytic Agents); 724L30Y2QR (Ursodeoxycholic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE


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[PMID]:28063745
[Au] Autor:Dirksen K; Fieten H
[Ad] Endereço:Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
[Ti] Título:Canine Copper-Associated Hepatitis.
[So] Source:Vet Clin North Am Small Anim Pract;47(3):631-644, 2017 May.
[Is] ISSN:1878-1306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Copper-associated hepatitis is recognized with increasing frequency in dogs. The disease is characterized by centrolobular hepatic copper accumulation, leading to hepatitis and eventually cirrhosis. The only way to establish the diagnosis is by histologic assessment of copper distribution and copper quantification in a liver biopsy. Treatment with the copper chelator d-penicillamine is the most commonly used treatment. In addition, a low-copper/high-zinc diet can help prevent accumulation or reaccumulation of hepatic copper. Mutations in the copper metabolism genes COMMD1 or ATP7A and ATP7B have been associated with hepatic copper concentrations in Bedlington terriers and Labrador retrievers respectively. In the Labrador retriever, dietary copper intake contributes strongly to the disease phenotype.
[Mh] Termos MeSH primário: Doenças do Cão
Hepatite Animal
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Biomarcadores/urina
Quelantes/uso terapêutico
Cobre/farmacologia
Doenças do Cão/diagnóstico
Doenças do Cão/genética
Doenças do Cão/fisiopatologia
Doenças do Cão/terapia
Cães
Hepatite Animal/diagnóstico
Hepatite Animal/genética
Hepatite Animal/fisiopatologia
Hepatite Animal/terapia
Seres Humanos
Penicilamina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biomarkers); 0 (Chelating Agents); 789U1901C5 (Copper); GNN1DV99GX (Penicillamine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE



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