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[PMID]:29256285
[Au] Autor:Carnevali V; Nogueda-Torres B; Villagrán-Herrera ME; De Diego-Cabrera JA; Rocha-Chávez G; Martínez-Ibarra JA
[Ad] Endereço:1 Department of Public Health and Infectious Diseases, University of Rome , Rome , Italy.
[Ti] Título:Prevalence of Trypanosoma cruzi and organ alterations in Virginia opossums (Didelphis virginiana) from western Mexico - short communication.
[So] Source:Acta Vet Hung;65(4):505-509, 2017 12.
[Is] ISSN:0236-6290
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:Small populations of Virginia opossum (Didelphis virginiana) in western Mexico are endangered by hunting and natural predators as well as by different kinds of diseases. After two serological analyses using Serodia® latex particle agglutination and indirect haemagglutination (IHA) tests, 35 (53.03%) of 66 collected opossums in two small towns in western Mexico were positive for the presence of Trypanosoma cruzi. Twenty-eight of the 35 seropositive opossums had pathological lesions: 11 had changes in only one organ, 13 in two organs, and four had pathological changes in three organs. Splenomegaly was the most common finding in the examined opossums, followed by hepatomegaly. These potentially fatal pathological changes could contribute to the scarcity of the opossum population, even leading to the extinction of this species in western Mexico.
[Mh] Termos MeSH primário: Didelphis/parasitologia
Trypanosoma cruzi/isolamento & purificação
Tripanossomíase/veterinária
[Mh] Termos MeSH secundário: Animais
Cardiomegalia/epidemiologia
Cardiomegalia/parasitologia
Cardiomegalia/veterinária
Acalasia Esofágica/epidemiologia
Acalasia Esofágica/parasitologia
Acalasia Esofágica/veterinária
Hepatomegalia/epidemiologia
Hepatomegalia/parasitologia
Hepatomegalia/veterinária
México/epidemiologia
Esplenomegalia/epidemiologia
Esplenomegalia/parasitologia
Esplenomegalia/veterinária
Tripanossomíase/epidemiologia
Tripanossomíase/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE
[do] DOI:10.1556/004.2017.048


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[PMID]:28467818
[Au] Autor:Janda CY; Dang LT; You C; Chang J; de Lau W; Zhong ZA; Yan KS; Marecic O; Siepe D; Li X; Moody JD; Williams BO; Clevers H; Piehler J; Baker D; Kuo CJ; Garcia KC
[Ad] Endereço:Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, and Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.
[Ti] Título:Surrogate Wnt agonists that phenocopy canonical Wnt and ß-catenin signalling.
[So] Source:Nature;545(7653):234-237, 2017 05 11.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells by inducing ß-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the co-receptors LRP5 and LRP6 to regulate cell fate decisions and the growth and repair of several tissues. The 19 mammalian Wnt proteins are cross-reactive with the 10 FZD receptors, and this has complicated the attribution of distinct biological functions to specific FZD and Wnt subtype interactions. Furthermore, Wnt proteins are modified post-translationally by palmitoylation, which is essential for their secretion, function and interaction with FZD receptors. As a result of their acylation, Wnt proteins are very hydrophobic and require detergents for purification, which presents major obstacles to the preparation and application of recombinant Wnt proteins. This hydrophobicity has hindered the determination of the molecular mechanisms of Wnt signalling activation and the functional importance of FZD subtypes, and the use of Wnt proteins as therapeutic agents. Here we develop surrogate Wnt agonists, water-soluble FZD-LRP5/LRP6 heterodimerizers, with FZD5/FZD8-specific and broadly FZD-reactive binding domains. Similar to WNT3A, these Wnt agonists elicit a characteristic ß-catenin signalling response in a FZD-selective fashion, enhance the osteogenic lineage commitment of primary mouse and human mesenchymal stem cells, and support the growth of a broad range of primary human organoid cultures. In addition, the surrogates can be systemically expressed and exhibit Wnt activity in vivo in the mouse liver, regulating metabolic liver zonation and promoting hepatocyte proliferation, resulting in hepatomegaly. These surrogates demonstrate that canonical Wnt signalling can be activated by bi-specific ligands that induce receptor heterodimerization. Furthermore, these easily produced, non-lipidated Wnt surrogate agonists facilitate functional studies of Wnt signalling and the exploration of Wnt agonists for translational applications in regenerative medicine.
[Mh] Termos MeSH primário: Transdução de Sinais
Proteínas Wnt/agonistas
Proteínas Wnt/metabolismo
Via de Sinalização Wnt
beta Catenina/metabolismo
[Mh] Termos MeSH secundário: Animais
Diferenciação Celular
Linhagem da Célula
Proliferação Celular
Receptores Frizzled/metabolismo
Células HEK293
Hepatócitos/citologia
Hepatomegalia/metabolismo
Hepatomegalia/patologia
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Intestinos/citologia
Ligantes
Fígado/metabolismo
Fígado/patologia
Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo
Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo
Células Mesenquimais Estromais/citologia
Células Mesenquimais Estromais/metabolismo
Camundongos
Modelos Moleculares
Organoides/citologia
Organoides/metabolismo
Multimerização Proteica
Solubilidade
Técnicas de Cultura de Tecidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Frizzled Receptors); 0 (Ligands); 0 (Low Density Lipoprotein Receptor-Related Protein-5); 0 (Low Density Lipoprotein Receptor-Related Protein-6); 0 (Wnt Proteins); 0 (beta Catenin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180217
[Lr] Data última revisão:
180217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1038/nature22306


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[PMID]:29414276
[Au] Autor:Baltimore RS; Nimkin K; Sparger KA; Pierce VM; Plotkin SA
[Ad] Endereço:From the Departments of Pediatrics and Infection Prevention, Yale New Haven Children's Hospital, and the Departments of Pediatrics and Epidemiology, Yale School of Medicine and Yale School of Public Health, New Haven, CT (R.S.B.); the Departments of Radiology (K.N.), Pediatrics (K.A.S., V.M.P.), and
[Ti] Título:Case 4-2018: A Newborn with Thrombocytopenia, Cataracts, and Hepatosplenomegaly.
[So] Source:N Engl J Med;378(6):564-572, 2018 Feb 08.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Surdez/etiologia
Síndrome da Rubéola Congênita/diagnóstico
Trombocitopenia/etiologia
[Mh] Termos MeSH secundário: Abdome/diagnóstico por imagem
Encéfalo/diagnóstico por imagem
Catarata/etiologia
Diagnóstico Diferencial
Hepatomegalia/etiologia
Seres Humanos
Recém-Nascido
Masculino
Nigéria
Radiografia Torácica
Síndrome da Rubéola Congênita/complicações
Esplenomegalia/etiologia
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL CONFERENCE; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180208
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMcpc1706110


  4 / 5132 MEDLINE  
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[PMID]:28457121
[Au] Autor:Cainelli F; Tastanbekova V; Nurgaliev D; Lim N; Vento S
[Ad] Endereço:Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
[Ti] Título:Infantile Osteopetrosis in a Kazakh Boy.
[So] Source:Isr Med Assoc J;19(1):65-66, 2017 Jan.
[Is] ISSN:1565-1088
[Cp] País de publicação:Israel
[La] Idioma:eng
[Mh] Termos MeSH primário: Osteopetrose/diagnóstico
[Mh] Termos MeSH secundário: Anemia/etiologia
Hepatomegalia/etiologia
Seres Humanos
Lactente
Cazaquistão
Masculino
Doenças Raras
Esplenomegalia/etiologia
Trombocitopenia/etiologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29028831
[Au] Autor:Alcala M; Calderon-Dominguez M; Serra D; Herrero L; Ramos MP; Viana M
[Ad] Endereço:Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain.
[Ti] Título:Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice.
[So] Source:PLoS One;12(10):e0186579, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The use of antioxidant therapy in the treatment of oxidative stress-related diseases such as cardiovascular disease, diabetes or obesity remains controversial. Our aim is to demonstrate that antioxidant supplementation may promote negative effects if used before the establishment of oxidative stress due to a reduced ROS generation under physiological levels, in a mice model of obesity. METHODS: C57BL/6J mice were fed with a high-fat diet for 14 weeks, with (OE group) or without (O group) vitamin E supplementation. RESULTS: O mice developed a mild degree of obesity, which was not enough to induce metabolic alterations or oxidative stress. These animals exhibited a healthy expansion of retroperitoneal white adipose tissue (rpWAT) and the liver showed no signs of lipotoxicity. Interestingly, despite achieving a similar body weight, OE mice were insulin resistant. In the rpWAT they presented a reduced generation of ROS, even below physiological levels (C: 1651.0 ± 212.0; O: 3113 ± 284.7; OE: 917.6 ±104.4 RFU/mg protein. C vs OE p< 0.01). ROS decay may impair their action as second messengers, which could account for the reduced adipocyte differentiation, lipid transport and adipogenesis compared to the O group. Together, these processes limited the expansion of this fat pad and as a consequence, lipid flux shifted towards the liver, causing steatosis and hepatomegaly, which may contribute to the marked insulin resistance. CONCLUSIONS: This study provides in vivo evidence for the role of ROS as second messengers in adipogenesis, lipid metabolism and insulin signaling. Reducing ROS generation below physiological levels when the oxidative process has not yet been established may be the cause of the controversial results obtained by antioxidant therapy.
[Mh] Termos MeSH primário: Tecido Adiposo/efeitos dos fármacos
Resistência à Insulina
Hepatopatia Gordurosa não Alcoólica/induzido quimicamente
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
Vitamina E/efeitos adversos
[Mh] Termos MeSH secundário: Adipogenia/efeitos dos fármacos
Tecido Adiposo/patologia
Animais
Peso Corporal/efeitos dos fármacos
Dieta Hiperlipídica/efeitos adversos
Hepatomegalia/induzido quimicamente
Gordura Intra-Abdominal/efeitos dos fármacos
Gordura Intra-Abdominal/patologia
Masculino
Camundongos
Camundongos Obesos
Hepatopatia Gordurosa não Alcoólica/metabolismo
Hepatopatia Gordurosa não Alcoólica/patologia
Obesidade/induzido quimicamente
Obesidade/metabolismo
Obesidade/patologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 1406-18-4 (Vitamin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186579


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[PMID]:28732017
[Au] Autor:Tajebe F; Getahun M; Adem E; Hailu A; Lemma M; Fikre H; Raynes J; Tamiru A; Mulugeta Z; Diro E; Toulza F; Shkedy Z; Ayele T; Modolell M; Munder M; Müller I; Takele Y; Kropf P
[Ad] Endereço:Department of Immunology and Molecular Biology, University of Gondar, Gondar, Ethiopia.
[Ti] Título:Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites.
[So] Source:PLoS Negl Trop Dis;11(7):e0005727, 2017 Jul.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.
[Mh] Termos MeSH primário: Coinfecção/fisiopatologia
Enteropatias Parasitárias/fisiopatologia
Leishmaniose Visceral/fisiopatologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Índice de Massa Corporal
Medula Óssea/parasitologia
Estudos de Casos e Controles
Estudos Transversais
Citocinas/análise
Etiópia
Hepatomegalia/parasitologia
Seres Humanos
Modelos Logísticos
Masculino
Parasitos/classificação
Parasitos/isolamento & purificação
Índice de Gravidade de Doença
Esplenomegalia/parasitologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170813
[Lr] Data última revisão:
170813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0005727


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[PMID]:28717104
[Au] Autor:Yin G; Cao L; Du J; Jia R; Kitazawa T; Kubota A; Teraoka H
[Ad] Endereço:School of Veterinary Medicine, Rakuno Gakuen University.
[Ti] Título:Dexamethasone-induced hepatomegaly and steatosis in larval zebrafish.
[So] Source:J Toxicol Sci;42(4):455-459, 2017.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Fish hepatobiliary syndrome, characterized by hepatomegaly and fatty liver, has been frequently reported in many cultured fish species and has caused a dramatic economic loss in China. Glucocorticoids are thought to be important non-nutritional factors for hepatomegaly and fatty liver development. In the present study, a dexamethasone-induced zebrafish model of fatty liver and hepatomegaly was established, and the role of glucocorticoid receptor (GR) in the development of hepatomegaly and fatty liver was investigated using developing zebrafish. Exposure of larval zebrafish at 5 days post fertilization (dpf) to dexamethasone for 24 hr caused significant increases of liver size and number of fish with hepatic steatosis at 6 dpf. The increase of liver size caused by dexamethasone was significantly reversed by treatment with RU486, a GR antagonist, and by gene knock-down with a morpholino against the GR. The dexamethasone-induced hepatic steatosis was also inhibited by treatment with RU486. Overall, the results highlight larval zebrafish as a useful model for stress-induced liver failure.
[Mh] Termos MeSH primário: Dexametasona/toxicidade
Modelos Animais de Doenças
Fígado Gorduroso/induzido quimicamente
Glucocorticoides/toxicidade
Hepatomegalia/induzido quimicamente
Peixe-Zebra
[Mh] Termos MeSH secundário: Animais
Fígado Gorduroso/tratamento farmacológico
Fígado Gorduroso/genética
Técnicas de Silenciamento de Genes
Hepatomegalia/tratamento farmacológico
Hepatomegalia/genética
Mifepristona/farmacologia
Mifepristona/uso terapêutico
Receptores de Glucocorticoides/antagonistas & inibidores
Receptores de Glucocorticoides/genética
Receptores de Glucocorticoides/fisiologia
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Receptors, Glucocorticoid); 320T6RNW1F (Mifepristone); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.2131/jts.42.455


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[PMID]:28708902
[Au] Autor:Goebel J; Sulke M; Lazik-Palm A; Goebel T; Dechêne A; Bellendorf A; Mueller S; Umutlu L; Theysohn J
[Ad] Endereço:Department of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Germany.
[Ti] Título:Factors associated with contralateral liver hypertrophy after unilateral radioembolization for hepatocellular carcinoma.
[So] Source:PLoS One;12(7):e0181488, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Radioembolization for the treatment of hepatocellular carcinoma (HCC) induces liver volume changes referred to as "atrophy-hypertrophy complex". The aim of this study was to investigate lobar liver volume changes after unilateral radioembolization and to search for factors associated with hypertrophy of the untreated lobe. MATERIALS AND METHODS: Seventy-five patients were retrospectively evaluated. Inclusion criteria were: (1) right-lobar radioembolization for unresectable unilateral HCC, (2) available liver computed tomography scans before, 1, 3, and at least 6 months after radioembolization. Baseline patient characteristics included clinical features, laboratory results, spleen volume, and liver computed tomography. Absolute and relative (referred to the whole liver volume) liver lobe volumes (LLV) as well as relative LLV (rLLV) change per month were evaluated and compared. RESULTS: Absolute and relative contralateral LLV continuously increased after radioembolization (p<0.001). Mean relative contralateral LLV increased from 36±11.6% before radioembolization to 50±15.3% 6 months after radioembolization. Median contralateral rLLV increase/month (within first 6 months) was 2.5%. Contralateral rLLV increase/month was significantly lower in patients with ascites (p = 0.017) or platelet count <100/nl (p = 0.009). An inverse correlation of contralateral rLVV increase/month with spleen volume (p = 0.017), patient age (p = 0.024), Child Pugh score (p = 0.001), and tumor burden (p = 0.001) was found. CONCLUSIONS: Significant contralateral hypertrophy and ipsilateral atrophy were common after unilateral radioembolization. Small spleen volume, low patient age, low Child Pugh score, absence of ascites, platelet count ≥100/nl, and low tumor burden were associated with increased contralateral hypertrophy, indicating that younger patients with compensated cirrhosis might benefit most from radioembolization in a "bridge-to-resection" setting.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/terapia
Embolização Terapêutica
Hepatomegalia/etiologia
Neoplasias Hepáticas/terapia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Carcinoma Hepatocelular/mortalidade
Carcinoma Hepatocelular/patologia
Feminino
Hepatomegalia/diagnóstico por imagem
Seres Humanos
Fígado/diagnóstico por imagem
Fígado/fisiologia
Neoplasias Hepáticas/mortalidade
Neoplasias Hepáticas/patologia
Masculino
Meia-Idade
Contagem de Plaquetas
Compostos Radiofarmacêuticos/química
Estudos Retrospectivos
Índice de Gravidade de Doença
Baço/diagnóstico por imagem
Baço/fisiologia
Tomografia Computadorizada por Raios X
Carga Tumoral
Radioisótopos de Ítrio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0 (Yttrium Radioisotopes)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181488


  9 / 5132 MEDLINE  
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[PMID]:28687713
[Au] Autor:Mridha AR; Haczeyni F; Yeh MM; Haigh WG; Ioannou GN; Barn V; Ajamieh H; Adams L; Hamdorf JM; Teoh NC; Farrell GC
[Ad] Endereço:Liver Research Group, Australian National University Medical School at the Canberra Hospital, Garran, ACT, Australia.
[Ti] Título:TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival.
[So] Source:Clin Sci (Lond);131(16):2145-2159, 2017 Aug 15.
[Is] ISSN:1470-8736
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and aims TLR9 deletion protects against steatohepatitis due to choline-amino acid depletion and high-fat diet. We measured in human non-alcoholic steatohepatitis (NASH) livers, and tested whether TLR9 mediates inflammatory recruitment in three murine models of non-alcoholic fatty liver disease (NAFLD). Methods We assayed TLR mRNA in liver biopsies from bariatric surgery patients. Wild-type ( ), appetite-dysregulated mutant , and C57BL6/J mice and bone marrow (BM) chimeras were fed 0.2% cholesterol, high-fat, high sucrose (atherogenic[Ath]) diet or chow, and NAFLD activity score (NAS)/NASH pathology, macrophage/neutrophil infiltration, cytokines/chemokines, and cell death markers measured in livers. Results Hepatic and mRNA were increased in human NASH but not simple steatosis, and in Ath-fed mice with metabolic syndrome-related NASH. Ath-fed mice showed simple steatosis and less Th1 cytokines than mice were obese and diabetic, but necroinflammatory changes were less severe than mice. TLR9-expressing myeloid cells were critical for Th1 cytokine production in BM chimeras. BM macrophages from mice showed M2 polarization, were resistant to M1 activation by necrotic hepatocytes/other pro-inflammatory triggers, and provoked less neutrophil chemotaxis than Livers from Ath-fed mice appeared to exhibit more markers of necroptosis [receptor interacting protein kinase (RIP)-1, RIP-3, and mixed lineage kinase domain-like protein (MLKL)] than , and ∼25% showed portal foci of mononuclear cells unrelated to NASH pathology. CONCLUSION: Our novel clinical data and studies in overnutrition models, including those with diabetes and metabolic syndrome, clarify TLR9 as a pro-inflammatory trigger in NASH. This response is mediated via M1-macrophages and neutrophil chemotaxis.
[Mh] Termos MeSH primário: Mediadores da Inflamação/metabolismo
Hepatopatia Gordurosa não Alcoólica/metabolismo
Receptor Toll-Like 9/biossíntese
Regulação para Cima/fisiologia
[Mh] Termos MeSH secundário: Adiponectina/deficiência
Adulto
Animais
Cirurgia Bariátrica
Biópsia
Células Cultivadas
Citocinas/metabolismo
Dieta Hiperlipídica/efeitos adversos
Modelos Animais de Doenças
Feminino
Deleção de Genes
Hepatócitos/metabolismo
Hepatomegalia/prevenção & controle
Seres Humanos
Fígado/metabolismo
Fígado/patologia
Macrófagos/metabolismo
Síndrome Metabólica/metabolismo
Erros Inatos do Metabolismo/prevenção & controle
Camundongos Knockout
Neutrófilos/metabolismo
Hepatopatia Gordurosa não Alcoólica/patologia
Obesidade/prevenção & controle
RNA Mensageiro/genética
Receptor Toll-Like 9/deficiência
Receptor Toll-Like 9/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adiponectin); 0 (Cytokines); 0 (Inflammation Mediators); 0 (RNA, Messenger); 0 (TLR9 protein, human); 0 (Tlr9 protein, mouse); 0 (Toll-Like Receptor 9)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE
[do] DOI:10.1042/CS20160838


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[PMID]:28562515
[Au] Autor:Pekpak E; Sirvan Cetin B
[Ad] Endereço:Departments of *Pediatric Hematology and Oncology †Pediatric Infectious Disease, Gaziantep Cengiz Gokcek Maternity and Children Hospital, Gaziantep, Turkey.
[Ti] Título:Secondary Hemophagocytic Lymphohistocytosis in a Child With Brucellosis.
[So] Source:J Pediatr Hematol Oncol;39(8):e501-e503, 2017 Nov.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hemophagocytic lymphohistocytosis (HLH) is a potentially fatal hyperinflammatory syndrome that is characterized by proliferation of histiocytes and hemophagocytosis in different organs. The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high serum fasting triglyceride level or low fibrinogen level, and hemophagocytosis in the bone marrow, spleen, or lymph nodes. HLH can be classified as primary and secondary. Secondary HLH can be related to infections. Here we report a case of Brucella-related HLH, which has been rarely reported in the literature.
[Mh] Termos MeSH primário: Brucelose/complicações
Linfo-Histiocitose Hemofagocítica/diagnóstico
Linfo-Histiocitose Hemofagocítica/etiologia
[Mh] Termos MeSH secundário: Adolescente
Antibacterianos/uso terapêutico
Biomarcadores
Medula Óssea/patologia
Brucelose/diagnóstico
Brucelose/tratamento farmacológico
Citofagocitose
Feminino
Febre
Hepatomegalia
Seres Humanos
Imunoglobulinas Intravenosas/uso terapêutico
Linfo-Histiocitose Hemofagocítica/terapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biomarkers); 0 (Immunoglobulins, Intravenous)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1097/MPH.0000000000000849



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