Base de dados : MEDLINE
Pesquisa : C07.465.114 [Categoria DeCS]
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[PMID]:28642559
[Au] Autor:Fischoff DK; Spivakovsky S
[Ad] Endereço:NYU College of Dentistry, New York, USA.
[Ti] Título:Little evidence to support or refute interventions for the management of burning mouth syndrome.
[So] Source:Evid Based Dent;18(2):57-58, 2017 06 23.
[Is] ISSN:1476-5446
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Data sourcesCochrane Oral Health's Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline Ovid, Embase Ovid, US National Institutes of Health Ongoing Trials Register (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform. Handsearch of the proceedings from the British Society for Oral Medicine (BSOM), British Society for Dental Research (BSDR) and the International Association for Dental Research (IADR).Study selectionAll included studies were randomised placebo controlled trials comparing a treatment to placebo with no language or year of publication restrictions. Symptom relief and changes in quality of life were considered primary outcomes.Data extraction and synthesisTeams of two authors independently screened for inclusion, extracted data using an ad-hoc tool and assessed the risk of bias using the Cochrane's tool. Outcomes were analysed for <3 months (short term) and ≥3 to ≤6 months (long term). For single studies with multiple interventions, the number of participants in the control group was adjusted to half before combining the results. For crossover studies without washout periods, the first period was analysed. RRs (risk ratios) and 85% confidence intervals were calculated for dichotomous outcomes and MDs (mean differences) and 95% confidence intervals for continuous data.ResultsA total of 23 studies encompassing 1121 patients were included. One study was considered as having overall low risk of bias, four unclear and the rest as high risk of bias. The interventions were grouped into: antidepressants and antipsychotics, anticonvulsants, benzodiazepines, cholinergics, dietary supplements, electromagnetic radiation, physical barriers, psychological therapies and topical treatments. Short-term symptom relief was demonstrated by: energy waves (one study, 58 participants) MD -30.36, 95% CI -44.22 to -16.50, physical barriers (one study, 50 participants) MD -1.1 95% CI -2.14 to 0.06, the anticonvulsant gabapentin (one study, 100 participants) RR 4.00, 95% CI 2.09 to 7.67 and topical benzodiazepine (two studies, 111 participants) MD -1.89 95% CI -2.19 to -1.59. Long term symptom relief was achieved with topical benzodiazepine (one study, 66 participants) MD -1.39 95% CI -1.96 to 0.83ConclusionsFrom studies mostly classified as high risk of bias, there is insufficient evidence to support or refute the use of any particular intervention for the management of BMS.
[Mh] Termos MeSH primário: Síndrome da Ardência Bucal
Qualidade de Vida
[Mh] Termos MeSH secundário: Anticonvulsivantes
Antidepressivos
Seres Humanos
Saúde Bucal
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Antidepressive Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.1038/sj.ebd.6401244


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[PMID]:28437511
[Au] Autor:Alnafea S; Fedele S; Porter S; Ni Riordain R
[Ti] Título:Online Information on the Treatment of Burning Mouth Syndrome: Quality and Readability.
[So] Source:J Oral Facial Pain Headache;31(2):147-151, 2017 Spring.
[Is] ISSN:2333-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIMS: To evaluate the quality and readability of online information about the treatment of burning mouth syndrome (BMS). METHODS: An internet search using the phrase "burning mouth syndrome treatment" was carried out on the Google search engine (www.google.co.uk) on 8 June 2015, and the first 100 websites listed were examined. Data collection included DISCERN score, the Journal of the American Medical Association (JAMA) benchmarks for website analysis score, the presence of the Health on the Net (HON) Foundation seal, and the Flesch Reading Ease Score (FRES). Descriptive statistics were performed using Microsoft Office Excel. RESULTS: The search strategy initially yielded 635,000 links; following the application of the exclusion criteria, 53 sites remained for analysis. The overall DISCERN score varied between websites, with half of all websites achieving an overall score of 2 and none of these websites achieving the maximum score of 5. The mean score ± standard deviation (SD) was 2.4 ± 0.7. Only 10 (18.9%) of the websites achieved the four JAMA benchmarks while 3 (5.7%) of the websites did not achieve any of them. Only 9 (17%) displayed the HON seal. The FRES of the websites ranged from 32.4 to 82.2; the mean ± SD rating was 55.4 ± 10.7, which is considered to reflect fairly difficult reading. CONCLUSION: The information available online about BMS is of questionable quality and content. Perhaps engaging patients in determining what type and format of information they desire when searching online for health information could guide clinicians and researchers alike in providing reliable and readable information sources.
[Mh] Termos MeSH primário: Síndrome da Ardência Bucal/terapia
Compreensão
Informação de Saúde ao Consumidor
Internet
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.11607/ofph.1717


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[PMID]:28361345
[Au] Autor:Wada A; Shizukuishi T; Kikuta J; Yamada H; Watanabe Y; Imamura Y; Shinozaki T; Dezawa K; Haradome H; Abe O
[Ad] Endereço:Department of Radiology, Nihon University School of Medicine, 30-1 Oyamaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan. awada-ind@umin.net.
[Ti] Título:Altered structural connectivity of pain-related brain network in burning mouth syndrome-investigation by graph analysis of probabilistic tractography.
[So] Source:Neuroradiology;59(5):525-532, 2017 May.
[Is] ISSN:1432-1920
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Burning mouth syndrome (BMS) is a chronic intraoral pain syndrome featuring idiopathic oral pain and burning discomfort despite clinically normal oral mucosa. The etiology of chronic pain syndrome is unclear, but preliminary neuroimaging research has suggested the alteration of volume, metabolism, blood flow, and diffusion at multiple brain regions. According to the neuromatrix theory of Melzack, pain sense is generated in the brain by the network of multiple pain-related brain regions. Therefore, the alteration of pain-related network is also assumed as an etiology of chronic pain. In this study, we investigated the brain network of BMS brain by using probabilistic tractography and graph analysis. METHODS: Fourteen BMS patients and 14 age-matched healthy controls underwent 1.5T MRI. Structural connectivity was calculated in 83 anatomically defined regions with probabilistic tractography of 60-axis diffusion tensor imaging and 3D T1-weighted imaging. Graph theory network analysis was used to evaluate the brain network at local and global connectivity. RESULTS: In BMS brain, a significant difference of local brain connectivity was recognized at the bilateral rostral anterior cingulate cortex, right medial orbitofrontal cortex, and left pars orbitalis which belong to the medial pain system; however, no significant difference was recognized at the lateral system including the somatic sensory cortex. A strengthened connection of the anterior cingulate cortex and medial prefrontal cortex with the basal ganglia, thalamus, and brain stem was revealed. CONCLUSION: Structural brain network analysis revealed the alteration of the medial system of the pain-related brain network in chronic pain syndrome.
[Mh] Termos MeSH primário: Mapeamento Encefálico/métodos
Síndrome da Ardência Bucal/fisiopatologia
Imagem de Tensor de Difusão
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Casos e Controles
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Imagem Tridimensional
Meia-Idade
Medição da Dor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1007/s00234-017-1830-2


  4 / 865 MEDLINE  
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[PMID]:28357703
[Au] Autor:Mitsikostas DD; Ljubisavljevic S; Deligianni CI
[Ad] Endereço:Aeginition Hospital, National & Kapodistrian University of Athens, Athens, Greece. dimosmitsikostas@me.com.
[Ti] Título:Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome.
[So] Source:J Headache Pain;18(1):40, 2017 Dec.
[Is] ISSN:1129-2377
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly. There is no satisfactory treatment for BMS. We aimed to observe the long-term efficacy of high velanfaxine doses combined with systemic and topical administered clonazepam in a particular subgroup of BMS patients who do not respond to current clinical management. RESULTS: Eight (66.1 ± 6.2 years old females) out of 14 BMS patients fulfilled the inclusion criteria and were treated with venlafaxine (300 mg/d) and clonazepam (5 mg/d) for 35.4 ± 12.1 (mean ± SD) months. The average duration of the symptoms at baseline was 4.3 ± 1.4 years and the overall mean daily pain intensity score was 8.6 ± 1.3 (VAS); pain was in tongue and within the oral mucosa, accompanying by oral and facial dysesthesia. In five patients tasting was abnormal. All patients had positive history of concomitant primary headache. The average score of Hamilton Rating scale for Anxiety and Depression was 21 ± 4.2, and 26.1 ± 2.9, respectively. Previous ineffective treatments include anticonvulsants and anti-depressants. All patients responded (more than 50% decrease in VAS) after three months treatment (mean VAS 3.2 ± 2.2) with no remarkable adverse events. CONCLUSION: BMS deserves bottomless psychiatric evaluation and management when current available treatments fail. Treatment with venlafaxine combined with topical and systemic clonazepam may be effective in refractory BMS cases but further investigation in a large-scale controlled study is needed to confirm these results.
[Mh] Termos MeSH primário: Síndrome da Ardência Bucal/diagnóstico por imagem
Síndrome da Ardência Bucal/tratamento farmacológico
Dor Crônica/diagnóstico por imagem
Dor Crônica/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Anticonvulsivantes/uso terapêutico
Ansiedade/diagnóstico por imagem
Ansiedade/tratamento farmacológico
Ansiedade/epidemiologia
Síndrome da Ardência Bucal/epidemiologia
Doença Crônica
Dor Crônica/epidemiologia
Clonazepam/uso terapêutico
Comorbidade
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 5PE9FDE8GB (Clonazepam)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1186/s10194-017-0745-y


  5 / 865 MEDLINE  
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[PMID]:28346647
[Au] Autor:Hirsch A; Roussos A; Freels S
[Ad] Endereço:Smell and Taste Treatment and Research Foundation, 223 E. Erie St., Ste. 712, Chicago, IL 60611, USA. dr.hirsch@sbcglobal.net.
[Ti] Título:Validation of olfactory threshold testing methods.
[So] Source:Ear Nose Throat J;96(3):E4-E6, 2017 Mar.
[Is] ISSN:1942-7522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In patients with chemosensory complaints, a head-to-head comparison of unilateral olfaction threshold testing with the Phenyl Ethyl Alcohol Smell Threshold Test (PEA) and the OLFACT-RL Odor Threshold Test (OLFACT-RL) was undertaken. The charts of 23 consecutive patients presenting with chemosensory complaints seen at the Smell and Taste Treatment and Research Foundation were reviewed and information extracted per Institutional Review Board guidelines. All patients had undergone olfactory testing with the PEA test and the OLFACT-RL test in accordance with their published administration manuals. Using Spearman correlation coefficients to measure the statistical correlation between tests, we found evidence of a correlation between PEA and OLFACT-RL values on the left side only, overall (r = 0.49, p = 0.0184); in those who had hyposmia and did not have anosmia (r = 0.42, p = 0.0668); in those who did not have burning mouth syndrome (r = 0.46, p = 0.0304); and in those who did not have dysosmia (r = 0.47, p = 0.0553). There is no evidence of a correlation on the right side. The correlation for the left nostril suggests that these tests may be interchangeable. However, lack of correlation with the right nostril requires further investigation.
[Mh] Termos MeSH primário: Transtornos do Olfato/diagnóstico
Olfatometria/estatística & dados numéricos
Percepção Olfatória
Limiar Sensorial
[Mh] Termos MeSH secundário: Adulto
Idoso
Síndrome da Ardência Bucal/complicações
Síndrome da Ardência Bucal/psicologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Odorantes
Transtornos do Olfato/etiologia
Olfatometria/métodos
Valores de Referência
Olfato
Estatísticas não Paramétricas
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28326926
[Au] Autor:Ji EH; Diep C; Liu T; Li H; Merrill R; Messadi D; Hu S
[Ad] Endereço:1 School of Dentistry, University of California, Los Angeles, CA, USA.
[Ti] Título:Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics.
[So] Source:Mol Pain;13:1744806916686796, 2017 Jan.
[Is] ISSN:1744-8069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Burning mouth syndrome (BMS) is a chronic pain disorder characterized by severe burning sensation in normal looking oral mucosa. Diagnosis of BMS remains to be a challenge to oral healthcare professionals because the method for definite diagnosis is still uncertain. In this study, a quantitative saliva proteomic analysis was performed in order to identify target proteins in BMS patients' saliva that may be used as biomarkers for simple, non-invasive detection of the disease. By using isobaric tags for relative and absolute quantitation labeling and liquid chromatography-tandem mass spectrometry to quantify 1130 saliva proteins between BMS patients and healthy control subjects, we found that 50 proteins were significantly changed in the BMS patients when compared to the healthy control subjects ( p ≤ 0.05, 39 up-regulated and 11 down-regulated). Four candidates, alpha-enolase, interleukin-18 (IL-18), kallikrein-13 (KLK13), and cathepsin G, were selected for further validation. Based on enzyme-linked immunosorbent assay measurements, three potential biomarkers, alpha-enolase, IL-18, and KLK13, were successfully validated. The fold changes for alpha-enolase, IL-18, and KLK13 were determined as 3.6, 2.9, and 2.2 (burning mouth syndrome vs. control), and corresponding receiver operating characteristic values were determined as 0.78, 0.83, and 0.68, respectively. Our findings indicate that testing of the identified protein biomarkers in saliva might be a valuable clinical tool for BMS detection. Further validation studies of the identified biomarkers or additional candidate biomarkers are needed to achieve a multi-marker prediction model for improved detection of BMS with high sensitivity and specificity.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Síndrome da Ardência Bucal/metabolismo
Proteômica/métodos
[Mh] Termos MeSH secundário: Catepsina G/metabolismo
Ensaio de Imunoadsorção Enzimática
Feminino
Seres Humanos
Interleucina-18/metabolismo
Calicreínas/metabolismo
Masculino
Medição da Dor
Fosfopiruvato Hidratase/metabolismo
Curva ROC
Saliva/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Interleukin-18); EC 3.4.21.- (KLK13 protein, human); EC 3.4.21.- (Kallikreins); EC 3.4.21.20 (Cathepsin G); EC 4.2.1.11 (Phosphopyruvate Hydratase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1177/1744806916686796


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[PMID]:28283095
[Au] Autor:Aljanobi H; Sabharwal A; Krishnakumar B; Kramer JM
[Ad] Endereço:Department of Oral Diagnostics Sciences, State University of New York at Buffalo, Buffalo, NY, USA.
[Ti] Título:Is it Sjögren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;123(4):482-495, 2017 Apr.
[Is] ISSN:2212-4411
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sjögren's syndrome (SS) and burning mouth syndrome (BMS) typically occur in postmenopausal women. Although these conditions have significantly different etiopathogeneses, patients with SS or BMS often present with analogous oral complaints. The similarities between the two conditions have led to considerable confusion on the part of medical and dental practitioners, and those with BMS or SS often wait years to receive a diagnosis. Therefore, it is imperative for clinicians to understand the characteristic subjective and objective features of each disease and how these can be used to distinguish them. This review will discuss the proposed etiology, clinical manifestations, histopathology, diagnostic criteria, and patient management of SS and BMS. We also identify key differences between the two pathoses that aid in establishing the correct diagnosis. Recognition of the defining features of each condition will lead to reduced time to diagnosis and improved patient management for these poorly understood conditions.
[Mh] Termos MeSH primário: Síndrome da Ardência Bucal/diagnóstico
Síndrome da Ardência Bucal/etiologia
Síndrome de Sjogren/diagnóstico
Síndrome de Sjogren/etiologia
[Mh] Termos MeSH secundário: Síndrome da Ardência Bucal/patologia
Síndrome da Ardência Bucal/terapia
Diagnóstico Diferencial
Seres Humanos
Síndrome de Sjogren/patologia
Síndrome de Sjogren/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28251232
[Au] Autor:Alnazzawi AA
[Ad] Endereço:College of Dentistry, Taibah University, Al Madinah Al Munawara, Kingdom of Saudi Arabia. E mail. deoaah@icloud.com.
[Ti] Título:Oral diseases associated with fixed prosthodontic restorations.
[So] Source:Saudi Med J;38(3):322-324, 2017 Mar.
[Is] ISSN:0379-5284
[Cp] País de publicação:Saudi Arabia
[La] Idioma:eng
[Ab] Resumo:[No Abstract Available].
[Mh] Termos MeSH primário: Prótese Parcial Fixa
Dermatite de Contato/epidemiologia
Hiperpigmentação/epidemiologia
Erupções Liquenoides/epidemiologia
Doenças da Boca/epidemiologia
[Mh] Termos MeSH secundário: Síndrome da Ardência Bucal/epidemiologia
Ligas de Cromo
Dano ao DNA
Dermatite de Contato/etiologia
Seres Humanos
Hipersensibilidade/epidemiologia
Hipersensibilidade/etiologia
Metais/efeitos adversos
Níquel/efeitos adversos
Paládio/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chromium Alloys); 0 (Metals); 5TWQ1V240M (Palladium); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE
[do] DOI:10.15537/smj.2017.3.18645


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[PMID]:28029722
[Au] Autor:Braud A; Descroix V; Ungeheuer MN; Rougeot C; Boucher Y
[Ad] Endereço:UFR Odontologie, Université Paris Diderot, Paris, France.
[Ti] Título:Taste function assessed by electrogustometry in burning mouth syndrome: a case-control study.
[So] Source:Oral Dis;23(3):395-402, 2017 Apr.
[Is] ISSN:1601-0825
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Idiopathic burning mouth syndrome (iBMS) is characterized by oral persistent pain without any clinical or biological abnormality. The aim of this study was to evaluate taste function in iBMS subjects and healthy controls. MATERIAL AND METHODS: Electrogustometric thresholds (EGMt) were recorded in 21 iBMS patients and 21 paired-matched controls at nine loci of the tongue assessing fungiform and foliate gustatory papillae function. Comparison of EGMt was performed using the nonparametric Wilcoxon signed-rank test. A correlation between EGMt and self-perceived pain intensity assessed using a visual analogic scale (VAS) was analyzed with the Spearman coefficient. The level of significance was fixed at P < 0.05. RESULTS: Mean EGMt were significantly increased with iBMS for right side of the dorsum of the tongue and right lateral side of the tongue (P < 0.05). In the iBMS group, VAS scores were significantly correlated to EGMt at the tip of the tongue (r = -0.59; P < 0.05) and at the right and left lateral sides of the tongue (respectively, r = -0.49 and r = -0.47; P < 0.05). CONCLUSION: These data depicted impaired taste sensitivity in iBMS patients within fungiform and foliate taste bud fields and support potent gustatory/nociceptive interaction in iBMS.
[Mh] Termos MeSH primário: Síndrome da Ardência Bucal/fisiopatologia
Papilas Gustativas/fisiopatologia
Limiar Gustativo
Paladar/fisiologia
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE
[do] DOI:10.1111/odi.12630


  10 / 865 MEDLINE  
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[PMID]:28007005
[Au] Autor:Jørgensen MR; Pedersen AM
[Ad] Endereço:a Department of Odontology, Section for Oral Medicine, Clinical Oral Physiology, Oral Anatomy and Pathology, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen N , Denmark.
[Ti] Título:Analgesic effect of topical oral capsaicin gel in burning mouth syndrome.
[So] Source:Acta Odontol Scand;75(2):130-136, 2017 Mar.
[Is] ISSN:1502-3850
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS). MATERIAL AND METHODS: This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days. A visual analogue scale (VAS) was used to assess the severity of pain five times during the intervention period. RESULTS: 18 patients completed the intervention. Their VAS score at baseline was 5.5 ± 0.6 cm (mean ± SD). Treatment with the two concentrations of capsaicin gels significantly improved the burning/stinging symptoms assessed on VAS compared with baseline (p = 0.002). There was no statistically significant difference between the two concentrations of the gels on relieving symptoms. Four patients dropped out during the intervention period due to gastrointestinal side-effects. CONCLUSIONS: Topical capsaicin might be an alternative for the short-term treatment of BMS. However, further studies are needed to investigate especially the gastro-intestinal side-effects which may limit its long-term use.
[Mh] Termos MeSH primário: Analgésicos/administração & dosagem
Síndrome da Ardência Bucal/tratamento farmacológico
Capsaicina/administração & dosagem
Fármacos do Sistema Sensorial/administração & dosagem
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Idoso
Síndrome da Ardência Bucal/prevenção & controle
Estudos Cross-Over
Método Duplo-Cego
Feminino
Seres Humanos
Meia-Idade
Dor/tratamento farmacológico
Medição da Dor
Resultado do Tratamento
Escala Visual Analógica
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics); 0 (Sensory System Agents); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161224
[St] Status:MEDLINE
[do] DOI:10.1080/00016357.2016.1269191



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