Base de dados : MEDLINE
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[PMID]:29328639
[Au] Autor:Dubovina D; Mihailovic B; Bukumiric Z; Vlahovic Z; Miladinovic M; Mikovic N; Lazic Z
[Ti] Título:The use of hyaluronic and aminocaproic acid in the treatment of alveolar osteitis.
[So] Source:Vojnosanit Pregl;73(11):1010-5, 2016 Nov.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: Alveolar osteitis (AO), also known as "dry socket", is relatively common post-extraction complication. It probably occurs due to excessive fibrinolytic activity in the coagulum and is characterized by intense pain sensations. The aim of this clinical study was to examine the role of hyaluronic acid and aminocaproic acid in the treatment of AO. Methods: The study included 60 patients with the clinical diagnosis of AO. All the patients were divided into two groups of 30 patients each according to the applied non-pharmacological measure: irrigation ­ irrigation of dry socket with sterile saline; curettage ­ careful curettage. Both of these groups were further divided into three subgroups regarding the applied treatment (hyaluronic acid; hyaluronic acid + aminocaproic acid; Alvogyl ®, an anesthetic and antiseptic paste), each with 10 patients, according to the following protocol: 0.2 mL of hyaluronic acid in the form of a 0.8% gel; 2 mL of aminocaproic acid and hyaluronic acid; Alvogyl®. During each visit, scheduled for every two days until complete absence of painful sensations, the patients had the therapeutic method repeated as at the first examination. At each control visit the number of present symptoms and signs of AO was recorded, as well as the level of pain (measured with a visual analogue scale). Results: With the use of hyaluronic acid, with or without aminocaproic one, a statistically significantly faster reduction in pain sensations was achieved, along with the reduction in the number of symptoms and signs of AO compared to the use of Alvogyl®. Conclusion: Hyaluronic acid, applied alone or in combination with aminocaproic acid significantly reduces pain sensation, thus it can be successfully used in the treatment of AO.
[Mh] Termos MeSH primário: Ácido Aminocaproico/uso terapêutico
Analgésicos/uso terapêutico
Alvéolo Seco/tratamento farmacológico
Eugenol/uso terapêutico
Dor Facial/prevenção & controle
Ácido Hialurônico/uso terapêutico
Hidrocarbonetos Iodados/uso terapêutico
Óleos Voláteis/uso terapêutico
para-Aminobenzoatos/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Ácido Aminocaproico/efeitos adversos
Analgésicos/efeitos adversos
Curetagem/efeitos adversos
Combinação de Medicamentos
Alvéolo Seco/diagnóstico
Eugenol/efeitos adversos
Dor Facial/diagnóstico
Dor Facial/etiologia
Dor Facial/fisiopatologia
Feminino
Seres Humanos
Ácido Hialurônico/efeitos adversos
Hidrocarbonetos Iodados/efeitos adversos
Masculino
Meia-Idade
Óleos Voláteis/efeitos adversos
Medição da Dor
Percepção da Dor/efeitos dos fármacos
Limiar da Dor/efeitos dos fármacos
Estudos Prospectivos
Sérvia
Irrigação Terapêutica
Fatores de Tempo
Resultado do Tratamento
para-Aminobenzoatos/efeitos adversos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics); 0 (Drug Combinations); 0 (Hydrocarbons, Iodinated); 0 (Oils, Volatile); 0 (butyl aminobenzoate, eugenol, iodoform, spearmint oil drug combinations); 0 (para-Aminobenzoates); 3T8H1794QW (Eugenol); 9004-61-9 (Hyaluronic Acid); U6F3787206 (Aminocaproic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150304125D


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[PMID]:28438595
[Au] Autor:Reiland MD; Ettinger KS; Lohse CM; Viozzi CF
[Ad] Endereço:Resident, Division of Oral and Maxillofacial Surgery, Department of Surgery, Mayo Clinic and Mayo College of Medicine, Rochester, MN. Electronic address: reiland.matthew@mayo.edu.
[Ti] Título:Does Administration of Oral Versus Intravenous Antibiotics for Third Molar Removal Have an Effect on the Incidence of Alveolar Osteitis or Postoperative Surgical Site Infections?
[So] Source:J Oral Maxillofac Surg;75(9):1801-1808, 2017 Sep.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To compare the incidence of postoperative alveolar osteitis (AO) and surgical site infections (SSIs) in 2 separate cohorts of patients undergoing elective third molar removal: those who received postoperative oral (PO) antibiotics and those who received perioperative intravenous (IV) antibiotics. MATERIALS AND METHODS: A retrospective cohort study of all patients 14 to 30 years old undergoing elective outpatient third molar removal under a single surgeon's service over a 12-year period was completed. Patients undergoing third molar removal during the first 72 months received postoperative PO antibiotics alone. Patients undergoing third molar removal during the second 72 months received perioperative IV antibiotics alone. The primary predictor variable for the study was the antibiotic regimen used at the time of third molar removal. The primary outcome variable was the postoperative development of AO or SSI. Covariates included age and gender. Univariable and multivariable regression models assessed for associations between the antibiotic regimen used and the presence of AO and SSI. RESULTS: The study sample consisted of 1,895 patients (1,020 patients receiving postoperative PO antibiotics and 875 patients receiving perioperative IV antibiotics). Of patients receiving postoperative PO antibiotics, 6.4% developed AO an average of 5.7 days after the procedure and 2.6% developed an SSI an average of 23.2 days after the procedure. Of patients receiving perioperative IV antibiotics, 5.5% developed AO an average of 6.2 days after the procedure and 3.3% developed an SSI an average of 18.2 days after the procedure. No statistically significant associations between the antibiotic regimen used and the presence of AO or SSI were identified in univariable (P = 0.42 for AO, P = 0.32 for SSI) or multivariable (P = 0.65 for AO, P = 0.26 for SSI) analyses. In the postoperative PO antibiotic cohort, older age (P < .001) and female gender (P < .001) were significantly associated with the development of AO, and female gender (P = .015) was significantly associated with the presence of an SSI. In the perioperative IV antibiotic cohort, female gender was significantly associated with the development of AO (P = .011), and younger age was significantly associated with the presence of an SSI (P = .011). CONCLUSION: The use of a postoperative PO versus a perioperative IV antibiotic regimen does not significantly alter the incidence of AO or SSI after elective third molar removal. If the surgeon chooses to use antibiotics in the setting of third molar surgery, then perioperative IV antibiotics are preferable over postoperative PO antibiotics because they obviate any issues with patient compliance and might be less costly.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Alvéolo Seco/prevenção & controle
Dente Serotino/cirurgia
Infecção da Ferida Cirúrgica/prevenção & controle
[Mh] Termos MeSH secundário: Administração Oral
Adolescente
Adulto
Antibioticoprofilaxia
Alvéolo Seco/epidemiologia
Feminino
Seres Humanos
Incidência
Injeções Intravenosas
Masculino
Minnesota/epidemiologia
Estudos Retrospectivos
Infecção da Ferida Cirúrgica/epidemiologia
Extração Dentária
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


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[PMID]:28189661
[Au] Autor:Rodríguez Sánchez F; Rodríguez Andrés C; Arteagoitia Calvo I
[Ad] Endereço:Master of Dentistry, Private Practitioner, Steenwijk, Netherlands. Electronic address: rs.fabio8@gmail.com.
[Ti] Título:Does Chlorhexidine Prevent Alveolar Osteitis After Third Molar Extractions? Systematic Review and Meta-Analysis.
[So] Source:J Oral Maxillofac Surg;75(5):901-914, 2017 May.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The prevention of alveolar osteitis (AO) in dental extractions remains a controversial issue. Chlorhexidine is one of the most widely studied antiseptics for the prevention of AO. The purpose of this systematic review and meta-analysis was to assess the efficacy and effectiveness of chlorhexidine in the prevention of AO after third molar extractions. MATERIALS AND METHODS: The authors searched databases and the references of each article retrieved up to December 2015. Clinical randomized controlled trials (RCTs) using only chlorhexidine were included. The predictor variable was whether chlorhexidine was used in any formulation, concentration, or regimen. The outcome measurement was the incidence of postoperative AO. The authors also recorded variables describing the characteristics of the included studies. Statistical analysis was performed using STATA 12.0. Meta-analysis of binary data was conducted using a fixed-effects model. Risk ratios and 95% confidence intervals (CIs) were estimated. Forest, l'Abbé, and funnel plots were constructed. RESULTS: Twenty-three studies published from 1979 to 2015, corresponding to 18 trials (16 parallel-group and 2 split-mouth RCTs), that reported on 2,824 third molar extractions (1,458 in experimental group and 1,366 in control group) were included. The overall relative risk (RR) was 0.53 (95% CI, 0.45-0.62; P < .0001). There was no evidence of heterogeneity (I = 9.3%; P = .336 by χ test). The number needed to treat was 8 (95% CI, 7-11). There were no relevant differences between chlorhexidine rinse (RR = 0.58; 95% CI, 0.47-0.71) and gel (RR = 0.47; 95% CI, 0.37-0.60). Chlorhexidine did not cause a larger proportion of adverse reactions than placebo. CONCLUSION: The use of chlorhexidine, in any formulation, concentration, or regimen, is efficacious and effective in preventing AO in patients who have undergone third molar extraction. Chlorhexidine gel was found to be moderately more efficacious than the rinse formulation.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Clorexidina/uso terapêutico
Alvéolo Seco/etiologia
Alvéolo Seco/prevenção & controle
Dente Serotino/cirurgia
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/prevenção & controle
Extração Dentária/efeitos adversos
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE


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[PMID]:28116438
[Au] Autor:Xu F; Zhang HX
[Ad] Endereço:Department of Stomatology, Zhengzhou First People's Hospital. Zhengzhou 450004, Henan Province, China. E-mail:xufang101010@163.com.
[Ti] Título:[Comparison of minimally invasive extraction and traditional method in the extraction of impacted mandibular third molar].
[So] Source:Shanghai Kou Qiang Yi Xue;25(5):613-616, 2016 Oct.
[Is] ISSN:1006-7248
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:PURPOSE: To compare minimally invasive extraction and traditional method in the extraction of impacted mandibular third molar. METHODS: One hundred and sixty patients with impacted mandibular third molar were equally divided into two groups. Patients in the experimental group were treated with minimally invasive extraction, using implant machine and luxator, while patients in the control group were treated with traditional methods including use of orthodox chisel. The operation time, intraoperative and postoperative complications including deformation of extraction sockets, dry socket, limitation of mouth opening, pain and swelling, and fear were observed and compared between the two groups. The data were analyzed with SPSS18.0 software package. RESULTS: The operation time was (17.32±1.01) min in the experimental group, significantly shorter than the control group which was (33.46±1.12)min (P<0.05); significant difference was found in the incidence of root fracture, medium or severe tooth sockets deformation and incidence of psychological fear during operation between the control group and experimental group(P<0.05); the degree of mouth opening after surgery, the incidence of moderate or severe pain after surgery was significantly lower in the experimental than in the control group(P<0.05). CONCLUSIONS: Minimally invasive extraction of mandibular impacted wisdom tooth is better than traditional method, with shorter operation time and less intraoperative and postoperative complications, which should be widely applied in clinic.
[Mh] Termos MeSH primário: Dente Serotino
Dente Molar
Extração Dentária/métodos
Dente Impactado/terapia
[Mh] Termos MeSH secundário: Adulto
Alvéolo Seco
Edema
Feminino
Seres Humanos
Masculino
Mandíbula
Dor Pós-Operatória
Complicações Pós-Operatórias
Raiz Dentária
Alvéolo Dental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


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[PMID]:27636763
[Au] Autor:Chergeshtov UI; Tsarev VN; Volkov AG; Nosik AS; Dikopova NJ; Malanchuk DA
[Ad] Endereço:Chairs of microbiology, virology and immunology, maxillofacial, reconstructively-regenerative and plastic surgery, parodontology MGMSU of A.I. Evdokimova, Moskow, Russia.
[Ti] Título:Clinical-microbiological research of action ozone therapy and light-emetting diode radiation of red range (630 nanometers) on microflora of the hole extracted toothatalveolitis and limited osteomyelitis of jaws.
[Ti] Título:Kliniko-mikrobiologicheskoe issledovanie deistviya ozonoterapii i svetodiodnogo izlucheniya krasnogo diapazona (630 nm) na mikrofloru lunki udalennogo zuba pri al'veolite i ogranichennom osteomielite chelyustei..
[So] Source:Stomatologiia (Mosk);95(4):53-57, 2016.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:As a result of cliniko-microbiological research the data testifying to substantial improvement of efficiency of antimicrobictherape at inclusion in a complex of medical actions at alveolitis and the limited osteomyelitis of a jow ozone therapy in a combination with a light-emettinf diode irradiation of the hole extracted teeth red ( 630 nanometers) are obtained by light.
[Mh] Termos MeSH primário: Alvéolo Seco/microbiologia
Doenças Maxilomandibulares/cirurgia
Lasers Semicondutores/uso terapêutico
Osteomielite/cirurgia
Ozônio/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Bactérias/efeitos dos fármacos
Bactérias/efeitos da radiação
Alvéolo Seco/radioterapia
Alvéolo Seco/cirurgia
Fungos/efeitos dos fármacos
Fungos/efeitos da radiação
Seres Humanos
Doenças Maxilomandibulares/microbiologia
Meia-Idade
Osteomielite/microbiologia
Ozônio/farmacologia
Extração Dentária/efeitos adversos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
66H7ZZK23N (Ozone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.17116/stomat201695453-57


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[PMID]:27499028
[Au] Autor:Ramos E; Santamaría J; Santamaría G; Barbier L; Arteagoitia I
[Ad] Endereço:BioCruces Health Research Institute, Cruces University Hospital, University of the Basque Country (UPV/EHU), Bizkaia, Spain.
[Ti] Título:Do systemic antibiotics prevent dry socket and infection after third molar extraction? A systematic review and meta-analysis.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;122(4):403-25, 2016 Oct.
[Is] ISSN:2212-4411
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The use of antibiotics to prevent dry socket and infection is a controversial but widespread practice. The aim of the study is to assess the efficacy of systemic antibiotics in reducing the frequencies of these complications after extraction. STUDY DESIGN: A systematic review and meta-analysis, according to the PRISMA statement, based on randomized double-blind placebo-controlled trials evaluating systemic antibiotics to prevent dry socket and infection after third molar surgery. Databases were searched up to June 2015. Relative risks (RRs) were calculated with inverse variance-weighted, fixed-effect, or random-effect models. RESULTS: We included 22 papers in the qualitative and 21 in the quantitative review (3304 extractions). Overall-RR was 0.43 (95% confidence interval [CI] 0.33-0.56; P < .0001); number needed to treat, 14 (95% CI 11-19). Penicillins-RR: 0.40 (95% CI 0.27-0.59). Nitroimidazoles-RR: 0.56 (95% CI 0.38-0.82). No serious adverse events were reported. CONCLUSIONS: Systemic antibiotics significantly reduce the risk of dry socket and infection in third molar extraction.
[Mh] Termos MeSH primário: Antibioticoprofilaxia
Alvéolo Seco/prevenção & controle
Dente Serotino/cirurgia
Complicações Pós-Operatórias/prevenção & controle
Extração Dentária
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160809
[St] Status:MEDLINE


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[PMID]:27055733
[Au] Autor:Elo JA; Sun HH; Dong F; Tandon R; Singh HM
[Ad] Endereço:Associate Professor, Division of Oral and Maxillofacial Surgery, Western University of Health Sciences College of Dental Medicine, Pomona, California, USA; Assistant Professor, Department of Oral and Maxillofacial Surgery, Loma Linda University Medical Center, Loma Linda, California, USA. Electronic
[Ti] Título:Novel incision design and primary flap closure reduces the incidence of alveolar osteitis and infection in impacted mandibular third molar surgery.
[So] Source:Oral Surg Oral Med Oral Pathol Oral Radiol;122(2):124-33, 2016 Aug.
[Is] ISSN:2212-4411
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To measure the influence of flap design on alveolar osteitis (AO) and postoperative complications following mandibular third molar surgery. STUDY DESIGN: This study was designed as a randomized single-blind, split-mouth clinical trial. The predictor variable was flap type. Envelope flap, modified triangular flap (MTF), and two related experimental flaps (second molar mesial papilla-sparing marginal incision with distobuccal release with double-pass single-layered primary closure [MPMI-2 X] and single-pass single-layered primary closure [MPMI-1 X]) were used. The primary outcome variable was AO. The secondary outcome variables were wound dehiscence and infection. Bivariate and logistic analyses were computed. P value < .05 was considered to be statistically significant. RESULTS: One hundred ninety-six patients with symmetric bilateral partial bony or full bony impacted mandibular third molars participated. No sites (0 of 196) treated with MPMI-2 X developed AO, and only two sites (2 of 196) treated with MPMI-2 X developed postoperative infection. Both MPMI-1 X and MPMI-2 X were associated with decreased odds of complications compared with MTF and envelope flap. MPMI-2 X sites were significantly less likely than MTF sites to experience complications for both sides. CONCLUSIONS: MPMI-2 X is a reliable technique to reduce complications, such as AO, wound dehiscence, and infection in mandibular third molar surgery.
[Mh] Termos MeSH primário: Alvéolo Seco/prevenção & controle
Infecção Focal Dentária/prevenção & controle
Dente Serotino/cirurgia
Complicações Pós-Operatórias/prevenção & controle
Retalhos Cirúrgicos
Deiscência da Ferida Operatória/prevenção & controle
Dente Impactado/cirurgia
[Mh] Termos MeSH secundário: Instrumentos Odontológicos
Alvéolo Seco/epidemiologia
Feminino
Infecção Focal Dentária/epidemiologia
Seres Humanos
Masculino
Complicações Pós-Operatórias/epidemiologia
Deiscência da Ferida Operatória/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160409
[St] Status:MEDLINE


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[PMID]:26939153
[Au] Autor:Fernandes GJ; Hatton MN
[Ti] Título:Prevention of Alveolar Osteitis. A Case Report and Review of Literature.
[So] Source:N Y State Dent J;82(1):21-5, 2016 Jan.
[Is] ISSN:0028-7571
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alveolar osteitis (aka, "dry socket") is a frustrating complication of exodontia, especially in the posterior mandible. We describe a novel technique for its possible prevention. The method involves administration of doxycycline dispersed in a local anesthetic solution, along with the use of a Gelfoam carrier. The senior author has used this technique as a routine element of care for several decades without complication.
[Mh] Termos MeSH primário: Alvéolo Seco/prevenção & controle
[Mh] Termos MeSH secundário: Administração Tópica
Adulto
Periodontite Agressiva/terapia
Anestésicos Locais/administração & dosagem
Antibacterianos/administração & dosagem
Doxiciclina/administração & dosagem
Portadores de Fármacos
Seguimentos
Esponja de Gelatina Absorvível
Seres Humanos
Lidocaína/administração & dosagem
Masculino
Fumar
Técnicas de Sutura
Extração Dentária/métodos
Alvéolo Dental/efeitos dos fármacos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Anti-Bacterial Agents); 0 (Drug Carriers); 98PI200987 (Lidocaine); N12000U13O (Doxycycline)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160304
[Lr] Data última revisão:
160304
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE


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[PMID]:26850866
[Au] Autor:Sun H; Li L; Li C
[Ad] Endereço:Chengdu, China.
[Ti] Título:Is Intra-Socket Drug Delivery Appropriate?
[So] Source:J Oral Maxillofac Surg;74(5):873-4, 2016 May.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Alvéolo Seco
Extração Dentária
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:160207
[St] Status:MEDLINE


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[PMID]:26706491
[Au] Autor:Marcussen KB; Laulund AS; Jørgensen HL; Pinholt EM
[Ad] Endereço:Resident, Department of Oral and Maxillofacial Surgery, Koege University Hospital, Koege, Denmark.
[Ti] Título:A Systematic Review on Effect of Single-Dose Preoperative Antibiotics at Surgical Osteotomy Extraction of Lower Third Molars.
[So] Source:J Oral Maxillofac Surg;74(4):693-703, 2016 Apr.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We conducted a systematic review of randomized controlled trials (RCTs) to evaluate the effectiveness of a single dose of preoperative antibiotic administered perorally, intravenously, intramuscularly, or topically for preventing infection and alveolar osteitis in lower third molar surgical extraction applying osteotomy. MATERIALS AND METHODS: The Medline, Cochrane Library, and Embase databases were searched for RCTs until August 2015. The primary outcome measure was postoperative inflammatory reactions, with a subgroup analysis of surgical site infection (SSI) and alveolar osteitis. A risk-of-bias assessment of the included trials was done according to the Cochrane guidelines. RESULTS: A total of 53 RCTs were identified; however, only 10 could be included in the present review. A meta-analysis of the 10 trials showed a statistically significant reduction in SSI and alveolar osteitis when antibiotics had been used (odds ratio [OR] = 0.30; 95% confidence interval [CI], 0.19 to 0.47; P ≤ .00001). A subgroup meta-analysis of 6 trials showed that preoperative administration of antibiotics perorally or intravenously significantly reduced the incidence of SSI (OR = 0.19; 95% CI, 0.08 to 0.45; P = .0002). A meta-analysis of 5 trials showed that 2 g of preoperative oral amoxicillin was able to reduce the incidence of SSI and the difference was statistically significant (OR = 0.22; 95% CI, 0.08 to 0.59; P = .002). Seven trials reported on alveolar osteitis, 6 studies on oral use, 2 studies on amoxicillin, 2 on metronidazole, 2 on penicillin V, and 1 on the intravenous use of penicillin. The pooled results showed that preoperative antibiotics significantly reduced the prevalence of alveolar osteitis (OR = 0.35; 95% CI, 0.13 to 0.96; P = .04). The subgroup analysis showed that penicillin V was effective in reducing the incidence of alveolar osteitis (OR = 0.1; 95% CI, 0.03 to 0.30; P ≤ .0001). CONCLUSIONS: A single oral dose of 2 g of amoxicillin before lower third molar osteotomy surgical extraction significantly decreased the incidence of SSI. A single dose of 0.8 g of penicillin V before lower third molar osteotomy surgical extraction significantly decreased the incidence of alveolar osteitis.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Antibioticoprofilaxia/métodos
Dente Serotino/cirurgia
Osteotomia/métodos
Extração Dentária/métodos
[Mh] Termos MeSH secundário: Administração Intravenosa
Administração Oral
Administração Tópica
Alvéolo Seco/prevenção & controle
Seres Humanos
Injeções Intramusculares
Infecção da Ferida Cirúrgica/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160328
[Lr] Data última revisão:
160328
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:151227
[St] Status:MEDLINE



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