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[PMID]:28742619
[Au] Autor:Wang AL; Weinlander E; Metcalf BM; Barney NP; Gamm DM; Nehls SM; Struck MC
[Ad] Endereço:*Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI; †McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI; and ‡Waisman Center, University of Wisconsin-Madison, Madison WI.
[Ti] Título:Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers.
[So] Source:Cornea;36(11):1426-1428, 2017 Nov.
[Is] ISSN:1536-4798
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To report the clinical course of 6 patients with refractory neurotrophic corneal ulcers that were treated with topical insulin drops. METHODS: Retrospective chart review of patients who had neurotrophic corneal ulcers or epithelial defects refractory to standard medical and surgical treatment. Insulin drops, prepared by mixing regular insulin in artificial tears with a polyethylene glycol and propylene glycol base at a concentration of 1 unit per milliliter, were prescribed 2 to 3 times daily. RESULTS: Six patients, aged 2 to 73 years, developed neurotrophic corneal ulcers refractory to a range of medical and surgical treatments, including bandage contact lens, amniotic membrane grafting, and permanent tarsorrhaphy. Each patient was administered topical insulin drops with complete corneal reepithelialization within 7 to 25 days. CONCLUSIONS: Topical insulin may be a simple and effective treatment for refractory neurotrophic corneal ulcers. Further study is required to determine the clinical efficacy and side effect profile of insulin drops.
[Mh] Termos MeSH primário: Úlcera da Córnea/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Insulina/administração & dosagem
Doenças do Nervo Trigêmeo/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Tópica
Idoso
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Soluções Oftálmicas
Reepitelização
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (Insulin); 0 (Ophthalmic Solutions)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1097/ICO.0000000000001297


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[PMID]:28903153
[Au] Autor:Chucair-Elliott AJ; Gurung HR; Carr MM; Carr DJJ
[Ad] Endereço:Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
[Ti] Título:Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection.
[So] Source:Invest Ophthalmol Vis Sci;58(11):4670-4682, 2017 Sep 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Herpes simplex virus type-1 (HSV-1) is a leading cause of neurotrophic keratitis, characterized by decreased or absent corneal sensation due to damage to the sensory corneal innervation. We previously reported the elicited immune response to infection contributes to the mechanism of corneal nerve regression/damage during acute HSV-1 infection. Our aim is to further establish the involvement of infiltrated macrophages in the mechanism of nerve loss upon infection. Methods: Macrophage Fas-Induced Apoptosis (MAFIA) transgenic C57BL/6 mice were systemically treated with AP20187 dimerizer or vehicle (VEH), and their corneas, lymph nodes, and blood were assessed for CD45+CD11b+GFP+ cell depletion by flow cytometry (FC). Mice were ocularly infected with HSV-1 or left uninfected. At 2, 4, and/or 6 days post infection (PI), corneas were assessed for sensitivity and harvested for FC, nerve structure by immunohistochemistry, viral content by plaque assay, soluble factor content by suspension array, and activation of signaling pathways by Western blot analysis. C57BL6 mice were used to compare to the MAFIA mouse model. Results: MAFIA mice treated with AP20187 had efficient depletion of CD45+CD11b+GFP+ cells in the tissues analyzed. The reduction of CD45+CD11b+GFP+ cells recruited to the infected corneas of AP20187-treated mice correlated with preservation of corneal nerve structure and function, decreased protein concentration of inflammatory cytokines, and decreased STAT3 activation despite no changes in viral content in the cornea compared to VEH-treated animals. Conclusions: Our results suggest infiltrated macrophages are early effectors in the nerve regression following HSV-1 infection. We propose the neurodegeneration mechanism involves macrophages, local up-regulation of IL-6, and activation of STAT3.
[Mh] Termos MeSH primário: Córnea/inervação
Herpesvirus Humano 1/crescimento & desenvolvimento
Ceratite Herpética/imunologia
Macrófagos/fisiologia
Degeneração Neural/imunologia
Receptor de Fator Estimulador de Colônias de Macrófagos/metabolismo
Doenças do Nervo Trigêmeo/imunologia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Modelos Animais de Doenças
Citometria de Fluxo
Imuno-Histoquímica
Interleucina-6/metabolismo
Ceratite Herpética/patologia
Ceratite Herpética/virologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Degeneração Neural/patologia
Degeneração Neural/virologia
Fator de Transcrição STAT3/metabolismo
Tacrolimo/análogos & derivados
Tacrolimo/farmacologia
Nervo Trigêmeo/metabolismo
Doenças do Nervo Trigêmeo/patologia
Doenças do Nervo Trigêmeo/virologia
Ensaio de Placa Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AP20187); 0 (Interleukin-6); 0 (STAT3 Transcription Factor); 0 (Stat3 protein, mouse); 0 (interleukin-6, mouse); EC 2.7.10.1 (Receptor, Macrophage Colony-Stimulating Factor); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22159


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[PMID]:28727882
[Au] Autor:Petropoulos IN; Kamran S; Li Y; Khan A; Ponirakis G; Akhtar N; Deleu D; Shuaib A; Malik RA
[Ad] Endereço:Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
[Ti] Título:Corneal Confocal Microscopy: An Imaging Endpoint for Axonal Degeneration in Multiple Sclerosis.
[So] Source:Invest Ophthalmol Vis Sci;58(9):3677-3681, 2017 Jul 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate whether corneal confocal microscopy (CCM) detects axonal degeneration and whether this is associated with retinal nerve fiber degeneration and clinical disability in patients with multiple sclerosis (MS). Methods: Twenty-five patients with MS and 25 healthy control subjects underwent CCM, optical coherence tomography (OCT), and assessment of neurological disability using the expanded disability status scale (EDSS) and MS severity score (MSSS). Results: In patients with MS compared with controls, there was a significant reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and length (CNFL). There was no significant difference in CCM parameters between patients with optic neuritis (MS-ON) and without (MS-NON), or between relapsing-remitting (RRMS) and secondary-progressive MS (SPMS). There was significant thinning of the retinal nerve fiber layer (RNFL) in the global, temporal, temporal superior, and temporal inferior quadrants, with no difference between MS-ON and MS-NON. Patients with SPMS compared with RRMS had a significantly lower global, temporal superior, temporal inferior, nasal, and nasal superior RNFL. The EDSS and MSSS correlated significantly with CNBD, nasal, nasal superior, and nasal inferior RNFL and with CNBD and nasal inferior RNFL, respectively. Conclusions: CCM and OCT detect significant corneal and retinal nerve degeneration which relates to the severity of neurological deficits in patients with mild MS.
[Mh] Termos MeSH primário: Axônios/patologia
Córnea/inervação
Esclerose Múltipla/diagnóstico por imagem
Degeneração Neural/diagnóstico por imagem
Neurite Óptica/diagnóstico por imagem
Doenças do Nervo Trigêmeo/diagnóstico por imagem
Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Microscopia Confocal
Esclerose Múltipla/patologia
Degeneração Neural/patologia
Neurite Óptica/patologia
Células Ganglionares da Retina/patologia
Tomografia de Coerência Óptica
Doenças do Nervo Trigêmeo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22050


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[PMID]:28650386
[Au] Autor:Markoulli M; You J; Kim J; Duong CL; Tolentino JB; Karras J; Lum E
[Ad] Endereço:*PhD, MOptom, FAAO †PhD ‡PhD, BSci(Psychol) §BOptom(Hons), BSci ∥BSci(VisSci) **PhD, BOptom, FAAO School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia (MM, JY, JK, CLD, JBT, JK, EL); and Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia (MM, JY).
[Ti] Título:Corneal Nerve Morphology and Tear Film Substance P in Diabetes.
[So] Source:Optom Vis Sci;94(7):726-731, 2017 Jul.
[Is] ISSN:1538-9235
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This work aims to characterize the relationship between tear film neuropeptide substance P and the structural integrity of the sub-basal nerve plexus in diabetes. METHODS: Seventeen healthy control participants and nine participants with diabetes were recruited in this cross-sectional study. Total protein content and substance P concentrations were determined in the flush tears of participants. Corneal nerve morphology was assessed by capturing the corneal sub-basal nerve plexus using the Heidelberg Retinal Tomograph II with the Rostock Corneal Module (Heidelberg Engineering GmbH, Heidelberg, Germany) in the central cornea. Corneal nerve fiber density (CNFD) was measured using ACCMetrics (M.A. Dabbah, Imaging Science and Biomedical Engineering, Manchester, UK) on eight captured images. Comparisons between groups were made using independent samples t-tests. Correlations between parameters were analyzed using Pearson's correlations. RESULTS: Substance P concentrations were significantly higher in the tears of the control group compared to participants with diabetes (4150 ± 4752 and 1473 ± 1671 pg/mL, respectively, P = .047). There was no significant difference in total protein content between the groups (3.4 ± 1.8 and 2.6 ± 1.7 mg/mL in the control and diabetes groups, respectively, P = .262). CNFD was significantly lower in the participants with diabetes compared to the control group (16.1 ± 5.7 and 21.5 ± 7.0 mm/mm, respectively, P = .041). There was a moderate correlation between substance P and CNFD (r = 0.48, P = .01). CONCLUSIONS: Substance P is expressed at a significantly lower level in the tears of people with diabetes compared with healthy controls. The positive correlation between substance P and corneal nerve density indicates that substance P may be a potential biomarker for corneal nerve health.
[Mh] Termos MeSH primário: Córnea/inervação
Doenças da Córnea/patologia
Diabetes Mellitus Tipo 2/metabolismo
Proteínas do Olho/metabolismo
Substância P/metabolismo
Lágrimas/metabolismo
Doenças do Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Doenças da Córnea/metabolismo
Estudos Transversais
Diabetes Mellitus Tipo 2/patologia
Feminino
Seres Humanos
Masculino
Microscopia Confocal
Meia-Idade
Fibras Nervosas/patologia
Estudos Prospectivos
Nervo Trigêmeo/patologia
Doenças do Nervo Trigêmeo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Eye Proteins); 0 (tear proteins); 33507-63-0 (Substance P)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.1097/OPX.0000000000001096


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[PMID]:28578122
[Au] Autor:Yan KK; Wei JB; Lin W; Zhang YH; Zhang M; Li M
[Ad] Endereço:Department of Functional Neurosurgery, Central Hospital of Panzhihua City in Sichuan Province, Sichuan, China. Electronic address: yankekunyanwenhao@163.com.
[Ti] Título:Hemimasticatory Spasm with a Single Venous Compression Treated with Microvascular Decompression of the Trigeminal Motor Rootlet.
[So] Source:World Neurosurg;104:1050.e19-1050.e22, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hemimasticatory spasm is a very rare disorder of the trigeminal motor rootlet that is characterized by a paroxysmal involuntary contraction of the jaw-closing muscles. The mechanisms for hemimasticatory spasm remain unclear, and an efficient treatment strategy still needs to be developed. CASE DESCRIPTION: We report a case of a successful treatment of hemimasticatory spasm with single venous compression via microvascular decompression of the trigeminal motor rootlet. CONCLUSIONS: Our report shows that a single venous compression may be also responsible for idiopathic hemimasticatory spasm which can be cured by microvascular decompression. This is the first report on hemimasticatory compressed by a single vein in the world.
[Mh] Termos MeSH primário: Músculos da Mastigação
Cirurgia de Descompressão Microvascular/métodos
Espasmo/cirurgia
Doenças do Nervo Trigêmeo/cirurgia
Veias/cirurgia
[Mh] Termos MeSH secundário: Adulto
Eletromiografia
Feminino
Seres Humanos
Espasmo/etiologia
Doenças do Nervo Trigêmeo/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE


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[PMID]:28559083
[Au] Autor:Liebelt BD; Barber SM; Desai VR; Harper R; Zhang J; Parrish R; Baskin DS; Trask T; Britz GW
[Ad] Endereço:Department of Neurosurgery, Houston Methodist Neurological Institute, Houston, Texas, USA.
[Ti] Título:Superior Petrosal Vein Sacrifice During Microvascular Decompression: Perioperative Complication Rates and Comparison with Venous Preservation.
[So] Source:World Neurosurg;104:788-794, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To investigate potential effect of sacrifice of the superior petrosal vein (SPV) on postoperative complications after microvascular decompression (MVD). METHODS: Retrospective review of 98 consecutive patients undergoing MVD of cranial nerve V was performed. Frequency of division of the SPV during surgery was recorded, and postoperative complications and imaging were recorded and analyzed. In patients with complications, the specific anatomic variation of the superior petrosal venous complex was noted. RESULTS: Of 98 patients undergoing MVD, 83 (84.7%) had sacrifice of the SPV at the time of surgery, 12 (12.2%) had the SPV preserved, and 3 (3.1%) were revision operations. Four patients (4.8%) had complications deemed to be attributable to venous insufficiency or congestion. These included sigmoid sinus thrombosis with coincident cerebellar hemorrhage, midbrain and pontine infarction, hemiparesis with midbrain and pontine edema, and facial paresis with ischemia in the middle cerebellar peduncle. None of the patients with preserved SPV were symptomatic or had imaging changes consistent with venous congestion. CONCLUSIONS: Sacrifice of the SPV is often performed during MVD. This is associated with a complication rate that is significant in frequency and severity compared with preserving the vein. SPV sacrifice should be limited to cases where it is deemed absolutely necessary for successful cranial nerve decompression.
[Mh] Termos MeSH primário: Veias Cerebrais/cirurgia
Cirurgia de Descompressão Microvascular/métodos
Síndromes de Compressão Nervosa/cirurgia
Complicações Pós-Operatórias/etiologia
Doenças do Nervo Trigêmeo/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Veias Cerebrais/diagnóstico por imagem
Cavidades Cranianas/diagnóstico por imagem
Cavidades Cranianas/cirurgia
Eletrocoagulação
Feminino
Seres Humanos
Hiperemia/diagnóstico por imagem
Hiperemia/etiologia
Masculino
Meia-Idade
Síndromes de Compressão Nervosa/diagnóstico por imagem
Complicações Pós-Operatórias/diagnóstico por imagem
Estudos Retrospectivos
Doenças do Nervo Trigêmeo/diagnóstico por imagem
Insuficiência Venosa/diagnóstico por imagem
Insuficiência Venosa/etiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE


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[PMID]:28271298
[Au] Autor:Brazoloto TM; de Siqueira SR; Rocha-Filho PA; Figueiredo EG; Teixeira MJ; de Siqueira JT
[Ad] Endereço:Dentistry Division of the Central Institute and Neurosurgical Division of the Psychiatry Institute, Hospital das Clínicas of the Medical School of University of São Paulo (USP), Avenida Doutor Enéas Carvalho de Aguiar, 255, 6º andar, sala 2, São Paulo, SP, 05403-900, Brazil. thibrazoloto@gmail.com.
[Ti] Título:Post-operative orofacial pain, temporomandibular dysfunction and trigeminal sensitivity after recent pterional craniotomy: preliminary study.
[So] Source:Acta Neurochir (Wien);159(5):799-805, 2017 May.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Surgical trauma at the temporalis muscle is a potential cause of post-craniotomy headache and temporomandibular disorders (TMD). The aim of this study was to evaluate the prevalence of pain, masticatory dysfunction and trigeminal somatosensory abnormalities in patients who acquired aneurysms following pterional craniotomy. METHODS: Fifteen patients were evaluated before and after the surgical procedure by a trained dentist. The evaluation consisted of the (1) research diagnostic criteria for TMD, (2) a standardized orofacial pain questionnaire and (3) a systematic protocol for quantitative sensory testing (QST) for the trigeminal nerve. RESULTS: After pterional craniotomy, 80% of the subjects, 12 patients, developed orofacial pain triggered by mandibular function. The pain intensity was measured by using the visual analog scale (VAS), and the mean pain intensity was 3.7. The prevalence of masticatory dysfunction was 86.7%, and there was a significant reduction of the maximum mouth opening. The sensory evaluation showed tactile and thermal hypoesthesia in the area of pterional access in all patients. CONCLUSIONS: There was a high frequency of temporomandibular dysfunction, postoperative orofacial pain and trigeminal sensory abnormalities. These findings can help to understand several abnormalities that can contribute to postoperative headache or orofacial pain complaints after pterional surgeries.
[Mh] Termos MeSH primário: Aneurisma Roto/cirurgia
Craniotomia/efeitos adversos
Dor Facial/etiologia
Transtornos da Cefaleia Secundários/etiologia
Transtornos da Articulação Temporomandibular/etiologia
Doenças do Nervo Trigêmeo/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Base do Crânio/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1007/s00701-017-3137-9


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[PMID]:28260625
[Au] Autor:Bhatkar S; Goyal MK; Takkar A; Mukherjee KK; Singh P; Singh R; Lal V
[Ad] Endereço:Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
[Ti] Título:Cavernous sinus syndrome: A prospective study of 73 cases at a tertiary care centre in Northern India.
[So] Source:Clin Neurol Neurosurg;155:63-69, 2017 Apr.
[Is] ISSN:1872-6968
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To study the clinical and etiological profile of patients with cavernous sinus syndrome (CSS) and identify factors which could determine the etiology and influence the outcome of these patients. PATIENTS AND METHODS: This prospective observational study included 73 consecutive patients satisfying the criteria of CSS (i.e. involvement of any 2 of the 3rd, 4th, 5th and 6th cranial nerves or any one of them with radiological evidence of cavernous sinus involvement). All these patients were subjected to detailed haematological, biochemical and radiological investigations and diagnosed and treated as per guidelines. The clinical and investigational data was recorded and analysed meticulously. RESULTS: A definitive etiological diagnosis of CSS could be achieved in 86% of patients. Tumours, fungal infections and Tolosa Hunt syndrome (THS) were most common causes. On univariate analysis, diabetes, severe vision loss (visual acuity of <3/60 in at least one eye), and presence of nasal discharge showed a significantly positive association with a fungal CSS. Evidence of paranasal sinusitis, bone erosion and ICA (internal carotid artery) involvement on Gadolinium enhanced MRI (magnetic resonance imaging) of brain were significantly associated with a fungal CSS (p=0.0001), whereas involvement of orbital apex had a negative association with a neoplastic etiology (p=0.014). On multiple logistic regression, orbital apex involvement on MRI was associated with diagnosis of THS (p=0.019, OR: 18.7; 95% CI: 1.6-217.4) while MRI evidence of paranasal sinusitis (p=0.014, OR: 45; 95% CI: 2.1-94.3) and bone erosion ((p=0.019, OR: 12.5; 95% CI: 1.5-103) correlated with diagnosis of fungal CSS. 65.2% of patients (fungal CSS- 70%) had a good prognosis at six months follow up. CONCLUSION: Most patients with CSS can be diagnosed accurately and managed properly with good outcomes.
[Mh] Termos MeSH primário: Seio Cavernoso/fisiopatologia
Seio Cavernoso/cirurgia
[Mh] Termos MeSH secundário: Doenças do Nervo Abducente/patologia
Doenças do Nervo Abducente/cirurgia
Adolescente
Adulto
Idoso
Seio Cavernoso/patologia
Criança
Feminino
Seres Humanos
Índia
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Estudos Prospectivos
Sinusite/diagnóstico
Sinusite/cirurgia
Centros de Atenção Terciária
Doenças do Nervo Trigêmeo/patologia
Doenças do Nervo Trigêmeo/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


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[PMID]:28176234
[Au] Autor:Tyburski AL; Cheng L; Assari S; Darvish K; Elliott MB
[Ad] Endereço:Department of Neurosurgery, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA.
[Ti] Título:Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system.
[So] Source:J Headache Pain;18(1):16, 2017 Dec.
[Is] ISSN:1129-2377
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Frequent mild head injuries or concussion along with the presence of headache may contribute to the persistence of concussion symptoms. METHODS: In this study, the acute effects of recovery between mild head injuries and the frequency of injuries on a headache behavior, trigeminal allodynia, was assessed using von Frey testing up to one week after injury, while histopathological changes in the trigeminal pain pathway were evaluated using western blot, ELISA and immunohistochemistry.  RESULTS: A decreased recovery time combined with an increased mild closed head injury (CHI) frequency results in reduced trigeminal allodynia thresholds compared to controls. The repetitive CHI group with the highest injury frequency showed the greatest reduction in trigeminal thresholds along with greatest increased levels of calcitonin gene-related peptide (CGRP) in the trigeminal nucleus caudalis. Repetitive CHI resulted in astrogliosis in the central trigeminal system, increased GFAP protein levels in the sensory barrel cortex, and an increased number of microglia cells in the trigeminal nucleus caudalis. CONCLUSIONS: Headache behavior in rats is dependent on the injury frequency and recovery interval between mild head injuries. A worsening of headache behavior after repetitive mild head injuries was concomitant with increases in CGRP levels, the presence of astrocytosis, and microglia proliferation in the central trigeminal pathway. Signaling between neurons and proliferating microglia in the trigeminal pain system may contribute to the initiation of acute headache after concussion or other traumatic brain injuries.
[Mh] Termos MeSH primário: Peptídeo Relacionado com Gene de Calcitonina/metabolismo
Traumatismos Craniocerebrais/complicações
Gliose/etiologia
Cefaleia/etiologia
Hiperalgesia/etiologia
Microglia/metabolismo
Núcleo Inferior Caudal do Nervo Trigêmeo/metabolismo
Doenças do Nervo Trigêmeo/etiologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Cefaleia/metabolismo
Hiperalgesia/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Doenças do Nervo Trigêmeo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
83652-28-2 (Calcitonin Gene-Related Peptide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1186/s10194-017-0726-1


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[PMID]:27890182
[Au] Autor:Badger D; Aygun N
[Ad] Endereço:Division of Neuroradiology, Johns Hopkins University, School of Medicine, 600 North Wolfe Street Phipps B100, Baltimore, MD 21287, USA.
[Ti] Título:Imaging of Perineural Spread in Head and Neck Cancer.
[So] Source:Radiol Clin North Am;55(1):139-149, 2017 Jan.
[Is] ISSN:1557-8275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perineural spread (PNS) of tumor is a recognized pattern of metastasis occurring in the head and neck. Imaging plays a critical role in identifying PNS for adequate staging and treatment planning. Understanding the major branches and pathways of cranial nerves V and VII, key anatomic landmarks, interconnections between these nerves, and pearls and pitfalls of PNS imaging can aid in early detection, appropriate therapy, and the best possible chance for cure.
[Mh] Termos MeSH primário: Neoplasias dos Nervos Cranianos/patologia
Doenças do Nervo Facial/patologia
Neoplasias de Cabeça e Pescoço/patologia
Imagem por Ressonância Magnética/métodos
Base do Crânio/patologia
Doenças do Nervo Trigêmeo/patologia
[Mh] Termos MeSH secundário: Neoplasias dos Nervos Cranianos/diagnóstico por imagem
Diagnóstico Diferencial
Nervo Facial
Doenças do Nervo Facial/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Seres Humanos
Invasividade Neoplásica/diagnóstico por imagem
Invasividade Neoplásica/patologia
Neuroimagem/métodos
Base do Crânio/diagnóstico por imagem
Nervo Trigêmeo/diagnóstico por imagem
Nervo Trigêmeo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE



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