Base de dados : MEDLINE
Pesquisa : C07.465.525 [Categoria DeCS]
Referências encontradas : 1013 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 102 ir para página                         

  1 / 1013 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28732181
[Au] Autor:Kousa YA; Roushangar R; Patel N; Walter A; Marangoni P; Krumlauf R; Klein OD; Schutte BC
[Ad] Endereço:1 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
[Ti] Título:IRF6 and SPRY4 Signaling Interact in Periderm Development.
[So] Source:J Dent Res;96(11):1306-1313, 2017 Oct.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rare mutations in IRF6 and GRHL3 cause Van der Woude syndrome, an autosomal dominant orofacial clefting disorder. Common variants in IRF6 and GRHL3 also contribute risk for isolated orofacial clefting. Similarly, variants within genes that encode receptor tyrosine kinase (RTK) signaling components, including members of the FGF pathway, EPHA3 and SPRY2, also contribute risk for isolated orofacial clefting. In the mouse, loss of Irf6 or perturbation of Fgf signaling leads to abnormal oral epithelial adhesions and cleft palate. Oral adhesions can result from a disruption of periderm formation. Here, we find that IRF6 and SPRY4 signaling interact in periderm function. We crossed Irf6 heterozygous ( Irf6 ) mice with transgenic mice that express Spry4 in the basal epithelial layer ( Tg ). While embryos with either of these mutations can have abnormal oral adhesions, using a new quantitative assay, we observed a nonadditive effect of abnormal oral epithelial adhesions in the most severely affected double mutant embryos ( Irf6 ;Tg ). At the molecular level, the sites of abnormal oral adhesions maintained periderm-like cells that express keratin 6, but we observed abnormal expression of GRHL3. Together, these data suggest that Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.
[Mh] Termos MeSH primário: Fenda Labial/genética
Fissura Palatina/genética
Fatores Reguladores de Interferon/genética
Proteínas do Tecido Nervoso/genética
Aderências Teciduais/genética
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/embriologia
Anormalidades Múltiplas/genética
Animais
Fenda Labial/embriologia
Fissura Palatina/embriologia
Cistos/embriologia
Cistos/genética
Modelos Animais de Doenças
Anormalidades Maxilomandibulares/embriologia
Anormalidades Maxilomandibulares/genética
Lábio/anormalidades
Lábio/embriologia
Camundongos
Camundongos Transgênicos
Anormalidades da Boca/embriologia
Anormalidades da Boca/genética
Mutação
Fenótipo
Transdução de Sinais
Aderências Teciduais/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IRF6 protein, mouse); 0 (Interferon Regulatory Factors); 0 (Nerve Tissue Proteins); 0 (Spry4 protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517719870


  2 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28673238
[Au] Autor:Arce-Estrada GE; Gómez-Toscano V; Cedillo-Peláez C; Sesman-Bernal AL; Bosch-Canto V; Mayorga-Butrón JL; Vargas-Villavicencio JA; Correa D
[Ad] Endereço:Laboratory Inmunología Experimental, Instituto Nacional de Pediatría (INP), Secretaría de Salud, Torre de Investigación, Av. Insurgentes Sur 3700-C, Col Insurgentes Cuicuilco, 04530, Ciudad de México, DF, Mexico.
[Ti] Título:Report of an unsual case of anophthalmia and craniofacial cleft in a newborn with Toxoplasma gondii congenital infection.
[So] Source:BMC Infect Dis;17(1):459, 2017 Jul 03.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We present one unusual case of anophthalmia and craniofacial cleft, probably due to congenital toxoplasmosis only. CASE PRESENTATION: A two-month-old male had a twin in utero who disappeared between the 7 and the 14 week of gestation. At birth, the baby presented anophthalmia and craniofacial cleft, and no sign compatible with genetic or exposition/deficiency problems, like the Wolf-Hirschhorn syndrome or maternal vitamin A deficiency. Congenital toxoplasmosis was confirmed by the presence of IgM abs and IgG neo-antibodies in western blot, as well as by real time PCR in blood. CMV infection was also discarded by PCR and IgM negative results. Structures suggestive of T. gondii pseudocysts were observed in a biopsy taken during the first functional/esthetic surgery. CONCLUSIONS: We conclude that this is a rare case of anophthalmia combined with craniofacial cleft due to congenital toxoplasmosis, that must be considered by physicians. This has not been reported before.
[Mh] Termos MeSH primário: Anoftalmia/parasitologia
Toxoplasmose Congênita/complicações
[Mh] Termos MeSH secundário: Antiprotozoários/uso terapêutico
Infecções por Citomegalovirus/diagnóstico
Feminino
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina M/sangue
Lactente
Recém-Nascido
Masculino
Anormalidades da Boca/diagnóstico por imagem
Anormalidades da Boca/parasitologia
Gravidez
Pirimetamina/uso terapêutico
Toxoplasma/patogenicidade
Toxoplasmose Congênita/diagnóstico por imagem
Ultrassonografia Pré-Natal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Immunoglobulin G); 0 (Immunoglobulin M); Z3614QOX8W (Pyrimethamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2565-8


  3 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28342902
[Au] Autor:de Vet HCW; Mokkink LB; Mosmuller DG; Terwee CB
[Ad] Endereço:Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, De Boelelaan 1089A, Amsterdam 1081HV, The Netherlands. Electronic address: hcw.devet@vumc.nl.
[Ti] Título:Spearman-Brown prophecy formula and Cronbach's alpha: different faces of reliability and opportunities for new applications.
[So] Source:J Clin Epidemiol;85:45-49, 2017 May.
[Is] ISSN:1878-5921
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: There are similarities between the different forms of reliability, such as internal consistency (internal reliability) and interrater and intrarater reliability. Reliability coefficients that are based on classical test theory can be expressed as intraclass correlation coefficients (ICCs), such as Cronbach's alpha. The Spearman-Brown prophecy formula (SB formula) is used to calculate the reliability when the number of items in a questionnaire is changed. This paper aims to increase insight into reliability studies by pointing to the assumptions of reliability coefficients, similarities between various coefficients, and the subsequent new applications of reliability coefficients. DESIGN, SETTINGS AND RESULTS: The origin and assumptions of Cronbach's alpha and the SB formula are discussed. Cronbach's alpha is written as an ICC formula, using the well-known property that taking the average value of a number of ratings increases the reliability of a measurement. We illustrate with an example that the ICC formulas for average measurements of multiple raters and the SB formula give similar results. This implies that the SB formula can be used to decide on the number of measurements to be averaged and thus on the number of raters required, for obtaining measurements with acceptable reliability, even if the variance components of the ICC formula are not known. Using the same example, we illustrate the principle of "Cronbach's alpha if item deleted" to decide on the poorest performing raters in a set of raters. CONCLUSION: These applications have different assumptions: the principle of "Cronbach's alpha if item deleted" is based on the assumption of a fixed set of items/raters and the SB formula is based on the assumption of random raters. The example also emphasizes the need for more raters in the design of the reliability study to obtain a robust estimation of reliability.
[Mh] Termos MeSH primário: Anormalidades da Boca/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/normas
Reprodutibilidade dos Testes
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Criança
Seres Humanos
Variações Dependentes do Observador
Psicometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170327
[St] Status:MEDLINE


  4 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27828687
[Au] Autor:Frelich A; Frelich J; Jez W; Irzyniec T
[Ti] Título:Selected clinical features of the head and neck in women with Turner syndrome and the 45,X/46,XY karyotype.
[So] Source:Endokrynol Pol;68(1):47-52, 2017.
[Is] ISSN:2299-8306
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: A 45,X/46,XY karyotype in women with Turner syndrome (TS) is very rare. The presence of a Y chromosome in the karyotype causes phenotypic differences and increased risk for neoplastic disease, compared to TS-women with other karyotypes. Our study addresses an issue: non-genital phenotypic differences between TS-patients with a Y-chromosome of their karyotype and TS-women without it. MATERIAL AND METHODS: Results from patient history/physical examinations of the head and neck of eight TS-women and the 45,X/46,XY karyotype were compared with those observed in 164 TS-women and 30 controls. The heights of TS-groups: 142.5 ± 7.2 and 144.9 ± 7.2 cm were lower than controls (165.2 ± 6.6 cm). Participants were examined from 1995 to 2014. RESULTS: Among 28 study parameters, 15 were more frequently observed in TS women with the 45,X/46,XY karyotype compared to controls. Only abnormalities in the oral cavity and a history of childhood lymphoedema, differed significantly in the TS groups. CONCLUSIONS: With respect to the head and neck, the patient history and physical examination results of TS-women and the 45,X/46,XY karyotype and TS and other karyotypes revealed similar differences compared to controls. Compared to others TS patients, 45,X/46,XY individuals might more frequently have oral cavity soft tissue abnormalities and more rarely a history of childhood lymphoedema. (Endokrynol Pol 2017; 68 (1): 47-52).
[Mh] Termos MeSH primário: Cromossomos Humanos
Cariótipo
Linfedema/genética
Anormalidades da Boca/genética
Síndrome de Turner/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Anormalidades da Boca/patologia
Síndrome de Turner/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161110
[St] Status:MEDLINE
[do] DOI:10.5603/EP.a2016.0063


  5 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27616609
[Au] Autor:Gjørup H; Haubek D; Jacobsen P; Ostergaard JR
[Ad] Endereço:Section of Oral Health in Rare Diseases, Department of Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark.
[Ti] Título:Nance-Horan syndrome-The oral perspective on a rare disease.
[So] Source:Am J Med Genet A;173(1):88-98, 2017 Jan.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study describes seven patients with Nance-Horan syndrome, all referred to a specialized oral care unit in the Central Denmark Region. A literature search on "Nance Horan Syndrome" resulted in 53 publications among which 29 reported on dental findings. Findings reported in these papers have been systematized to obtain an overview of the reported findings and the terminology on dental morphology. All seven patients included in the present study showed deviations of crown morphology on incisors and/or molars. The only consistent and very clear dental aberration was alterations in the tooth morphology that is screwdriver-shaped incisors and bud molars being most pronounced in the permanent dentition, but were also present in the primary dentition. In addition, three patients had supernumerary teeth, and three had dental agenesis. In conclusion, a dental examination as a part of the diagnostic process may reveal distinct characteristics of the dental morphology, which could be of diagnostic value and facilitate an early diagnosis. In the description of molar morphology in NHS patients, it is recommended to use the term "bud molar." The combination of congenital cataract, screwdriwer-shaped incisors and bud-shaped molars is a strong clinical indication of Nance-Horan syndrome. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Catarata/congênito
Doenças Genéticas Ligadas ao Cromossomo X/diagnóstico
Anormalidades da Boca
Fenótipo
Anormalidades Dentárias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Catarata/diagnóstico
Catarata/genética
Criança
Dinamarca
Facies
Doenças Genéticas Ligadas ao Cromossomo X/genética
Seres Humanos
Masculino
Anormalidades da Boca/diagnóstico
Anormalidades da Boca/genética
Radiografia
Doenças Raras
Anormalidades Dentárias/genética
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.37963


  6 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27388679
[Au] Autor:Zeytinoglu S; Davey MP; Crerand C; Fisher K; Akyil Y
[Ad] Endereço:Kozyatagi Acibadem Hospital.
[Ti] Título:Experiences of Couples Caring for a Child Born with Cleft Lip and/or Palate: Impact of the Timing of Diagnosis.
[So] Source:J Marital Fam Ther;43(1):82-99, 2017 Jan.
[Is] ISSN:1752-0606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Raising a child born with cleft lip and/or palate (CL/P) can be challenging for parents. Few researchers have examined how having a child born with CL/P impacts couples. The purpose of this descriptive qualitative study was to examine how a child's CL/P diagnosis affects couples' relational adjustment and coping. We conducted interviews with 17 couples (10 prenatal and seven postnatal) caring for children born with CL/P. After conducting thematic content analysis, six overarching themes emerged: (a) relationship growth, (b) challenges, (c) roles and responsibilities, (d) sources of support, (e) talking about cleft, and (f) lessons learned. Findings suggest that couples should be routinely assessed for psychosocial issues and prevention programs should be tailored to preexisting stressors and timing of the diagnosis.
[Mh] Termos MeSH primário: Adaptação Psicológica/fisiologia
Anormalidades da Boca/enfermagem
Pais/psicologia
Ajustamento Social
Cônjuges/psicologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Pesquisa Qualitativa
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1111/jmft.12182


  7 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28391256
[Au] Autor:Bednarczyk M
[Ad] Endereço:Klinika Neonatologii i Intensywnej Terapii Noworodka, Instytut Matki i Dziecka, Warszawa, e-mail: magda@mowa.pl.
[Ti] Título:[Lactation support and professional care in natural feeding for mothers of prenature infants and infants with anatomical disorders of facial skeleton - based on the literature and own experience].
[So] Source:Dev Period Med;20(5):358-371, 2016.
[Is] ISSN:1428-345X
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:According to the international and regional and european recommendations exclusive breast feeding for first 6 months of infant's life is the aim to achieve. Advantages of breast feeding and policy of breast feeding promotion were discussed in the article. Immaturity and/or functional disorders of sucking and anatomical disorders of oral cavity such as cleft lip, cleft palate, short frenulum of the tongue, were showed to be the most common causes of breast feeding problems. Proceedings promoting breast feeding in prenature infants according to lactation early stimulation programme for tertiary Neonatal and Obstetrical Units (2014) were also presented. Project of lactation support and help in feeding children with anatomical disorders of oral cavity with pumped mother's milk as well as scheme of introducing supplementary food were proposed.
[Mh] Termos MeSH primário: Métodos de Alimentação
Fenômenos Fisiológicos da Nutrição do Lactente
Leite Humano
Anormalidades da Boca
Guias de Prática Clínica como Assunto
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lactente
Recém-Nascido
Recém-Nascido Prematuro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170410
[St] Status:MEDLINE


  8 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28030924
[Au] Autor:Zawadzki PJ; Perkowski K; Starosciak B; Baltaza W; Padzik M; Pionkowski K; Chomicz L
[Ad] Endereço:Clinic of Cranio-Maxillo-Facial and Oral Surgery and Implantology, Medical University of Warsaw, Warsaw, Poland.
[Ti] Título:Identification of infectious microbiota from oral cavity environment of various population group patients as a preventive approach to human health risk factors.
[So] Source:Ann Agric Environ Med;23(4):566-569, 2016 12 23.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION AND OBJECTIVE: This study presents the results of comparative investigations aimed to determine microbiota that can occur in the oral environment in different human populations. The objective of the research was to identify pathogenic oral microbiota, the potential cause of health complications in patients of different population groups. MATERIALS AND METHOD: The study included 95 patients requiring dental or surgical treatment; their oral cavity environment microbiota as risk factors of local and general infections were assessed. RESULTS: In clinical assessment, differences occurred in oral cavity conditions between patients with malformations of the masticatory system, kidney allograft recipients and individuals without indications for surgical procedures. The presence of various pathogenic and opportunistic bacterial strains in oral cavities were revealed by direct microscopic and in vitro culture techniques. CONCLUSIONS: Colonization of oral cavities of patients requiring surgical treatment by the potentially pathogenic bacteria constitutes the threat of their spread, and development of general infections. Assessment of oral cavity infectious microbiota should be performed as a preventive measure against peri-surgical complications.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Microbiota
Boca/microbiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Transplante de Rim
Masculino
Meia-Idade
Anormalidades da Boca/microbiologia
Estudos Retrospectivos
Fatores de Risco
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.5604/12321966.1226847


  9 / 1013 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28005814
[Au] Autor:Wang XQ; Zhang WF; Wang YG; Bu LL; Hou M
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Henan Provincial People's Hospital, Zhengzhou, China.
[Ti] Título:Syngnathia Between the Palate and Mouth Floor, Cleft Palate, and Funnel Chest.
[So] Source:J Craniofac Surg;27(8):e762-e763, 2016 Nov.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Syngnathia is a rare malformation involving soft tissue and/or bony adhesions between the maxilla and mandible. Less than 40 patients have been reported in the literature. Here the authors report a 6-month-old infant diagnosed as syngnathia of the palate and mouth floor combined with cleft palate and funnel chest in the Department of Oral and Maxillofacial Surgery at Henan Provincial People's Hospital in January 2015. The authors discussed and evaluated the diagnostic and treatment difficulties on surgical and anesthetic procedure. There is no standard treatment protocol, but early treatment is necessary to improve airway functions and infant feeding, and to support proper nutrition for the growth of maxillofacial region.
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Fenda Labial/diagnóstico
Tórax em Funil/diagnóstico
Anormalidades Maxilomandibulares/diagnóstico
Anormalidades da Boca/diagnóstico
Soalho Bucal/anormalidades
[Mh] Termos MeSH secundário: Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003115


  10 / 1013 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27783616
[Au] Autor:Deguen S; Kihal W; Jeanjean M; Padilla C; Zmirou-Navier D
[Ad] Endereço:EHESP School of Public Health, Department of Environmental and Occupational Health, Rennes, Cedex 35043, France.
[Ti] Título:Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis.
[So] Source:PLoS One;11(10):e0159039, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We conducted this systematic review and meta-analysis to address the open question of a possible association between the socioeconomic level of the neighborhoods in which pregnant women live and the risk of Congenital Heart Defects (CHDs), Neural Tube Defects (NTDs) and OroFacial Clefts (OFCs). METHODS: We searched MEDLINE from its inception to December 20th, 2015 for case-control, cohort and ecological studies assessing the association between neighborhood socioeconomic level and the risk of CHDs, NTDs and the specific phenotypes Cleft Lip with or without Cleft Palate (CLP) and Cleft Palate (CP). Study-specific risk estimates were pooled according to random-effect and fixed-effect models. RESULTS: Out of 245 references, a total of seven case-control studies, two cohort studies and two ecological studies were assessed in the systematic review; all studies were enrolled in the meta-analysis with the exception of the two cohort studies. No significant association has been revealed between CHDs or NTDs and neighborhood deprivation index. For CLP phenotype subgroups, we found a significantly higher rate in deprived neighborhoods (Odds Ratios (OR) = 1.22, 95% CI: 1.10, 1.36) whereas this was not significant for CP phenotype subgroups (OR = 1.20, 95%CI: 0.89, 1.61). CONCLUSION: In spite of the small number of epidemiological studies included in the present literature review, our findings suggest that neighborhood socioeconomic level where mothers live is associated only with an increased risk of CLP phenotype subgroups. This finding has methodological limitations that impede the formulation of firm conclusions, and further investigations should confirm this association.
[Mh] Termos MeSH primário: Cardiopatias Congênitas/etiologia
Anormalidades da Boca/etiologia
Defeitos do Tubo Neural/etiologia
[Mh] Termos MeSH secundário: Bases de Dados Factuais
Feminino
Seres Humanos
Razão de Chances
Gravidez
Distribuição Espacial da População
Fatores de Risco
Fatores Socioeconômicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161027
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0159039



página 1 de 102 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde