Base de dados : MEDLINE
Pesquisa : C07.465.604 [Categoria DeCS]
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[PMID]:28412977
[Au] Autor:Tungotyo M
[Ad] Endereço:Mbarara University of Science and Technology, Mbarara, Uganda. mtungotyo@yahoo.com.
[Ti] Título:Noma as a complication of false teeth (Ebiino) extraction: a case report.
[So] Source:J Med Case Rep;11(1):112, 2017 Apr 17.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ebiino, also known as false tooth extraction, is a traditional practice done mainly in the remote areas of African countries, including Uganda. It involves the extraction of tooth buds in babies with common childhood illnesses such as fever, cough, and diarrhea. It is thought that the tooth buds are responsible for the ailments seen in these infants. The practice is performed by traditional healers using unsterile instruments. The complications associated with this dangerous practice have been mentioned in the literature and include anemia and septicemia, among others. This case report describes a baby with noma, an orofacial gangrenous infection. CASE PRESENTATION: A 16-month-old girl from western Uganda belonging to the Banyankole ethnic group was admitted to Mbarara University Teaching Hospital with a 5-day history of a dark lesion on the left cheek. The lesion had started from the left upper gum at the site where a tooth bud had been extracted 1 week prior to admission. The child had experienced occasional cough and fever and also had erupting tooth buds. These tooth buds had been seen as the cause of the cough and fever by the traditional herbalist; hence, they were extracted. An unsterile instrument had been used for the procedure. At the hospital, a local examination showed necrotic tissue involving the left cheek and extending into the left upper gingival area of the girl's mouth. A clinical diagnosis of orofacial gangrene (noma) was then made. CONCLUSIONS: Ebiino, or false tooth extraction, is still practiced in some remote areas of Uganda. Noma has been mentioned as a possible complication of this traditional practice; however, case reports in the literature are scant. Public awareness of the dangers of this practice is therefore still required to prevent this dangerous complication.
[Mh] Termos MeSH primário: Desbridamento/métodos
Febre/cirurgia
Medicina Tradicional Africana
Noma/diagnóstico
Extração Dentária/efeitos adversos
Germe de Dente/cirurgia
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Ceftriaxona/administração & dosagem
Feminino
Seres Humanos
Lactente
Medicina Tradicional Africana/efeitos adversos
Noma/terapia
Encaminhamento e Consulta
Germe de Dente/microbiologia
Uganda
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 75J73V1629 (Ceftriaxone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1276-5


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[PMID]:28093536
[Au] Autor:Srour ML; Marck K; Baratti-Mayer D
[Ad] Endereço:Health Frontiers, Vientiane, Laos. leila@butterflychildren.org.
[Ti] Título:Noma: Overview of a Neglected Disease and Human Rights Violation.
[So] Source:Am J Trop Med Hyg;96(2):268-274, 2017 Feb 08.
[Is] ISSN:1476-1645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Noma is an orofacial gangrene affecting malnourished children and mainly observed in tropical countries, particularly sub-Saharan Africa. Epidemiological data on noma are scarce, but a current estimate of the global incidence is 30,000-40,000 cases per year, with a mortality rate of approximately 85% and a burden of disease calculated to be a loss of 1-10 million disability-adjusted life years. The etiology of noma is multifactorial with malnutrition as an ever present factor, often in combination with concomitant diseases, such as measles, malaria, and human immunodeficiency virus (HIV), and poor oral hygiene. The pathogenesis is a fast-spreading, noncontagious gangrenous infection occurring in the face, often preceded by acute necrotizing gingivitis, and stomatitis. Rare microbiological studies suggest an opportunistic infection caused by an imbalance in normal intraoral microorganisms. Prevention lies in food security, measles vaccination, prevention of malaria and HIV, including the early detection and treatment of necrotizing gingivitis and stomatitis. Early treatment with antibiotics may prevent gangrene or reduce its extent. Late treatment consists of surgical rehabilitation, which is often complex. However, access to medical care is very limited for noma patients due to the extremely poor conditions in which they live that are frequently located in remote rural areas. The authors support the United Nations Human Rights Council Resolution 19/7 adopted on March 22, 2012 "The right to food," and advocate for the inclusion of noma on the list of neglected tropical diseases to encourage more medical and institutional attention for this often lethal or very mutilating infectious gangrene.
[Mh] Termos MeSH primário: Violações dos Direitos Humanos
Noma
[Mh] Termos MeSH secundário: África ao Sul do Saara/epidemiologia
Criança
Pré-Escolar
Seres Humanos
Doenças Negligenciadas/diagnóstico
Doenças Negligenciadas/epidemiologia
Doenças Negligenciadas/terapia
Noma/diagnóstico
Noma/epidemiologia
Noma/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.4269/ajtmh.16-0718


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[PMID]:26740267
[Au] Autor:Singh A; Mandal A; Seth R; Kabra SK
[Ad] Endereço:Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, New Delhi, India.
[Ti] Título:Noma in a child with acute leukaemia: when the 'face of poverty' finds an ally.
[So] Source:BMJ Case Rep;2016, 2016 Jan 06.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 2-year-6-month old, appropriately immunised, well-thriving boy, symptomatic for the past 6 months, presented with recurrent fever, progressive pallor, lymphadenopathy and a raw area on the right cheek, with discharging sinus. The necrotising infection of the face developed after one and half months of febrile illness. This febrile illness with bicytopaenia was diagnosed as enteric fever and treated with antibiotics. Skin grafting was performed for the full-thickness defect of the face. The patient continued to have a non-healing oral ulcer with progressive pallor and was finally diagnosed as having acute lymphoblastic leukaemia. Immunodeficiency was ruled out by appropriate investigations. Noma is an indirect measure of extreme poverty, but malignancy is known to predispose to this debilitating condition. The worldwide incidence of Noma is reported to be 30,000-140,000, with a preponderance in sub-Saharan Africa. This case emphasises the need for a thorough search for the underlying illness predisposing to a rare opportunistic infection such as Noma in a well-thriving child.
[Mh] Termos MeSH primário: Doença Aguda
Face
Leucemia/complicações
Noma/etiologia
[Mh] Termos MeSH secundário: Pré-Escolar
Terapia Combinada
Diagnóstico Diferencial
Seres Humanos
Masculino
Noma/tratamento farmacológico
Infecções Oportunistas/etiologia
Pobreza
Febre Tifoide/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160107
[Lr] Data última revisão:
160107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160108
[St] Status:MEDLINE


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[PMID]:26608690
[Au] Autor:Rodgers W; Lloyd T; Mizen K; Fourie L; Nishikawa H; Rakhorst H; Schmidt A; Kuoraite D; Bulstrode N; Dunaway D
[Ad] Endereço:Department of Plastic Surgery, Great Ormond Street Hospital for Children, UK. Electronic address: mr.w.rodgers@gmail.com.
[Ti] Título:Microvascular reconstruction of facial defects in settings where resources are limited.
[So] Source:Br J Oral Maxillofac Surg;54(1):51-6, 2016 Jan.
[Is] ISSN:1532-1940
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:The surgical treatment of defects caused by noma is challenging for the surgeon and the patient. Local flaps are preferred, but sometimes, because of the nature of the disease, there is not enough local tissue available. We describe our experience of free tissue transfer in Ethiopia. Between 2008 and 2014, 34 microsurgical procedures were done over 11 missions with the charity Facing Africa, predominantly for the treatment of defects caused by noma (n=32). The mean duration of operation was 442 minutes (range 200 - 720). Six minor wound infections were treated conservatively and did not affect outcome, a return to theatre was required in 4 patients with wound infections and one with a haemorrhage; 2 flaps failed and 2 partially failed, one patient developed an oronasal fistula, and one had an infection at the donor site that required a repeat graft. In settings where resources are limited, free flaps can be used when local tissue is not available and they cause less morbidity than pedicled tissue transfer.
[Mh] Termos MeSH primário: Face/cirurgia
Microvasos/cirurgia
Procedimentos Cirúrgicos Reconstrutivos
[Mh] Termos MeSH secundário: Retalhos de Tecido Biológico/cirurgia
Seres Humanos
Microcirurgia
Noma/cirurgia
Retalhos Cirúrgicos/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE


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[PMID]:26455659
[Au] Autor:Bouman MA; Dijkstra PU; Reintsema H; Roodenburg JL; Werker PM
[Ad] Endereço:University of Groningen, University Medical Center Groningen, Department of Plastic Surgery, Hanzeplein 1, P.O. Box 30.001, 9700 RB, Groningen, the Netherlands. Electronic address: mariabouman@gmail.com.
[Ti] Título:Surgery for extra-articular trismus: a systematic review.
[So] Source:Br J Oral Maxillofac Surg;54(3):253-9, 2016 Apr.
[Is] ISSN:1532-1940
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:The aim of this systematic review was to identify operations that are used to improve mouth opening in patients with extra-articular trismus (caused by cancer and its treatment, oral submucous fibrosis, or noma) and to find out if they work. We searched the electronic databases PubMed, Embase, Cinahl, and the Cochrane collaboration, and then systematically selected papers before we assessed their quality, extracted the data, and did a meta-analysis. We analysed 32 studies that included 651 patients, the median (IQR) size of which was 11 (7-26). The quality of the methods used and of reporting were relatively low. Median (IQR) duration of follow-up was 12 (8-22) months. Operations resulted in a weighted mean (SD) increase in mouth opening of 19.3 (6.3) mm. None of the operations was better than the others for the improvement of mouth opening. We conclude that operations can improve mouth opening in extra-articular trismus, but the evidence is of moderate quality and there is a need for further research.
[Mh] Termos MeSH primário: Trismo/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Noma
Fibrose Oral Submucosa
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:151013
[St] Status:MEDLINE


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[PMID]:26573028
[Au] Autor:Ashok N; Tarakji B; Darwish S; Rodrigues JC; Altamimi MA
[Ad] Endereço:. nipunashok@gmail.com.
[Ti] Título:A Review on Noma: A Recent Update.
[So] Source:Glob J Health Sci;8(4):53-9, 2015 Jul 30.
[Is] ISSN:1916-9736
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Noma is a gangrenous infection primarily affecting under developed countries. The aim of this paper was to review all recent articles on noma from January 2003 to August 2014 and briefly update the latest information related to the topic. A literature search was done on PUBMED using the keywords "noma/cancrum oris". Noma is commonly seen in malnourished children. There has been an increased incidence of noma in HIV patients. Apart from these, noma has also been reported in association with cyclic neutropenia, herpetic stomatitis, leukemia, Down's syndrome and Burkett's disease. Treatment of acute noma includes transfusion of blood and intravenous fluids, administration of antibiotics, putting the patient on a high protein diet and debridement of necrotic areas. Surgical phase is usually initiated 6 to 18 months after a period of quiescence. Although, the mortality rate associated with noma has reduced significantly with the advent of modern generation antibiotics, the functional, cosmetic and psychological challenges associated with the destruction of soft or hard tissues still remains a huge challenge. Adequate steps must be implemented by the government or medical professionals to prevent the disease and provide an early intervention.
[Mh] Termos MeSH primário: Noma/epidemiologia
Noma/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Incidência
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE
[do] DOI:10.5539/gjhs.v8n4p53


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[PMID]:26520001
[Au] Autor:Rodgers W; Lloyd T; Fourie L; Nishikawa H; Kuoraite D; Dunaway D; Bulstrode N
[Ad] Endereço:Department of Plastic Surgery, Great Ormond Street Hospital for Children, UK. Electronic address: mr.w.rodgers@gmail.com.
[Ti] Título:Total reconstruction of the nose in settings where resources are limited.
[So] Source:Br J Oral Maxillofac Surg;53(10):1001-6, 2015 Dec.
[Is] ISSN:1532-1940
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:We describe a series of 8 patients who had total reconstruction of the nose during 4 separate missions to Ethiopia. The aetiology was noma (n=3), assault (n=2), acid burn (n=1), squamous cell carcinoma (n=1), and a sequela of meningococcal septicaemia (n=1). Reconstruction was with forehead flaps when adequate tissue was available (n=6) and with radial forearm flaps when it was not (n=2). Some reconstructive approaches require procedures to be done in stages, and in settings where resources are limited, difficulties with the continuity of care and provision for the management of complications, must be overcome.
[Mh] Termos MeSH primário: Nariz/cirurgia
Procedimentos Cirúrgicos Reconstrutivos
[Mh] Termos MeSH secundário: Seres Humanos
Noma/cirurgia
Neoplasias Nasais/cirurgia
Retalhos Cirúrgicos/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:151102
[St] Status:MEDLINE


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[PMID]:26437752
[Au] Autor:García-Moro M; García-Merino E; Martín-Del-Rey A; García-Sánchez E; García-Sánchez JE
[Ad] Endereço:María García Moro, Facultad de Farmacia, Universidad de Salamanca, Spain. mgarciam@usal.es.
[Ti] Título:[Noma/Cancrum oris: a neglected disease].
[Ti] Título:La enfermedad de Noma/cancrum oris: una enfermedad olvidada..
[So] Source:Rev Esp Quimioter;28(5):225-34, 2015 Oct.
[Is] ISSN:1988-9518
[Cp] País de publicação:Spain
[La] Idioma:spa
[Ab] Resumo:Noma is an aggressive orofacial gangrenous pathology that damages hard and soft tissues of the mouth and the face. Throughout the centuries it has been present around the globe, but nowadays it has practically disappeared from developed countries and mainly affects children from the most disadvantaged places, especially in Africa. Noma disease is a multifactorial process; malnutrition, debilitating diseases (bacterial or viral systemic diseases, HIV-associated immunosuppression, etc.) and intraoral infections are some of the factors implied. The characteristic tissue necrosis is produced by a polymicrobial infection. Fusobacterium necrophorum, Prevotella intermedia, Prevotella melaninogenica, Fusobacterium nucleatum, Bacteroides fragilis, Bacillus cereus, Trueperella pyogenes, spyrochetes, etc, are some of the species that have been isolated from the affected areas. Without treatment, noma is lethal in a short period of time, and the patients that survive show severe sequelae that hinder their life and interpersonal relationships. The aim of this paper is to unify the existing information and to promote wider knowledge and awareness among the population.
[Mh] Termos MeSH primário: Doenças Negligenciadas
Noma
[Mh] Termos MeSH secundário: África/epidemiologia
Seres Humanos
Noma/epidemiologia
Noma/etiologia
Noma/microbiologia
Noma/mortalidade
Noma/patologia
Noma/terapia
Qualidade de Vida
Fatores de Risco
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1607
[Cu] Atualização por classe:151006
[Lr] Data última revisão:
151006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151007
[St] Status:MEDLINE


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[PMID]:26407438
[Au] Autor:Raimondi F; Veropalumbo C; Coppola C; Maddaluno S; Ferrara T; Cangiano G; Capasso L
[Ad] Endereço:Division of Neonatology, Department of Translational Medical Sciences.
[Ti] Título:Noma Neonatorum From Multidrug-Resistant Pseudomonas aeruginosa: An Underestimated Threat?
[So] Source:J Pediatric Infect Dis Soc;4(3):e25-7, 2015 Sep.
[Is] ISSN:2048-7207
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We present the case of an extremely low birth weight infant with diffuse gingival noma, initially misdiagnosed as thrush. Multidrug-resistant Pseudomonas aeruginosa strain was cultured and treated with systemic and local colistin with complete healing. Noma neonatorum from multidrug-resistant pathogens may appear in neonatal intensive care units. Old antibiotics may help.Noma (cancrum oris) is a devastating gangrenous disease that leads to destruction of facial tissue with significant morbidity and mortality in children and young adults. Noma has virtually disappeared from Europe and North America, but it is still common among children and young adults in India, Africa, and South America. Noma is a polymicrobial opportunistic infection related to malnutrition and immune dysfunction. In the neonate, a similar but distinct condition, known as "noma neonatorum" was described in 1977, in which gangrenous lesions involve the mucocutaneous junctions of oral, nasal, and anal area, and, occasionally, the eyelids and the scrotum. The neonatal disease has been linked to Pseudomonas aeruginosa, prematurity, and low birth weight. There is no established treatment, and mortality is almost inevitable in the few reported cases. In this study, we present the first European case of noma neonatorum from a multidrug-resistant strain of P aeruginosa.
[Mh] Termos MeSH primário: Colistina/uso terapêutico
Noma/diagnóstico
Noma/microbiologia
Infecções por Pseudomonas/complicações
Infecções por Pseudomonas/diagnóstico
Pseudomonas aeruginosa
[Mh] Termos MeSH secundário: Erros de Diagnóstico
Farmacorresistência Bacteriana Múltipla
Feminino
Gengiva/microbiologia
Gengiva/patologia
Seres Humanos
Recém-Nascido de Peso Extremamente Baixo ao Nascer
Recém-Nascido
Recém-Nascido Prematuro
Noma/tratamento farmacológico
Infecções por Pseudomonas/tratamento farmacológico
Infecções por Pseudomonas/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
Z67X93HJG1 (Colistin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150926
[St] Status:MEDLINE
[do] DOI:10.1093/jpids/piu072


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[PMID]:26235765
[Au] Autor:Zwetyenga N; See LA; Szwebel J; Beuste M; Aragou M; Oeuvrard C; Martin D; Emparanza A
[Ad] Endereço:Service de stomatologie, chirurgie maxillo-faciale, chirurgie plastique esthétique et reconstructrice, chirurgie de la main, centre hospitalier universitaire de Dijon, boulevard Delattre-de-Tassigny, 21000 Dijon, France; Laboratoire EA 4268 4IS, université de Franche-Comte, place Saint-Jacques, 3500
[Ti] Título:[Noma].
[Ti] Título:Le Noma..
[So] Source:Rev Stomatol Chir Maxillofac Chir Orale;116(4):261-79, 2015 Sep.
[Is] ISSN:2213-6541
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Noma is a necrotizing ulcerative stomatitis known since Antiquity. It occurs mostly in poor countries, the Sahel countries being the most affected. Each year, several hundred thousand cases are reported. Noma affects especially malnourished children who are less than 6 years old and rarely adults with acquired immunodeficiency (HIV, cancer). Ulcerative lesion is occurring rapidly due to the production of endotoxins by bacteria from oral commensal, telluric and animal origin. Necrotic debridement leads to huge defects: loss of soft tissue (skin, nerves, vessels, eye), bone (maxilla, mandible) and teeth. Death occurs rapidly in a few weeks in 80 % of the cases. In case of survival, the consequences are functional, aesthetic, psychological and social. The goal of the treatment in the acute phase is the patient's survival and the fight against limited mouth opening. The management of the phase of sequela is an anaesthetic, surgical and physiotherapy challenge. Its purpose is the social reintegration of the patient.
[Mh] Termos MeSH primário: Noma
[Mh] Termos MeSH secundário: Adulto
Criança
Pré-Escolar
Progressão da Doença
Geografia
História do Século XVII
História do Século XVIII
História do Século XIX
História do Século XX
História do Século XXI
Seres Humanos
Lactente
Recém-Nascido
Noma/epidemiologia
Noma/história
Noma/patologia
Noma/terapia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:150804
[St] Status:MEDLINE



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