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[PMID]: 29496808 [Au] Autor: Marlow AK; Hamada Y; Maupome G; Eckert GJ; John V [Ad] Endereço: Dr. Marlow is in private practice in Florence, KY; this study was conducted while she was a resident, Department of Periodontics and Allied Dental Program, Indiana University School of Dentistry; Dr. Hamada is Clinical Assistant Professor, Department of Periodontics and Allied Dental Program, Indian [Ti] Título: Periodontal Diagnosis and Treatment Planning Among Indiana Dental Faculty, Periodontists, and General Practice Dentists: A Multi-Group Comparison. [So] Source: J Dent Educ;82(3):291-298, 2018 Mar. [Is] ISSN: 1930-7837 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Diagnosis and treatment planning for periodontal disease are fraught with challenges because of the complex and multifactorial nature of the disease as well as the inherent variability in interpretation of clinical findings. It is important for all practitioners to be accurate and consistent in formulating diagnoses based on the American Academy of Periodontology classification guidelines and to implement treatment plans to adequately address patients' needs. The aim of this study was to compare diagnoses and treatment plans among four groups of participants: full-time and part-time periodontology faculty at Indiana University School of Dentistry (IUSD), full-time and part-time IUSD general practice faculty, full-time periodontists in private practice, and full-time general practitioners in private practice. The study, conducted September 2016 to February 2017, also sought to determine if the calibrated participants had more correct diagnoses and treatment plans than those who had not received calibration training. Each of the four groups had 20 participants each. Participants evaluated ten de-identified case records and selected a diagnosis and treatment plan for each case. In the results, the 20 IUSD periodontal faculty members, most of whom had participated in calibration sessions, had overall better agreement and more correct responses for diagnoses and treatment plans than the IUSD general practice faculty members, private practice general practitioners, and private practice periodontists (only one of those 60 participants had participated in calibration sessions). The results supported the notion that periodic calibration is needed to standardize faculty criteria, facilitate better agreement and accuracy, and enhance consistency in the use of clinical criteria during training for dental students and in practice. [Mh] Termos MeSH primário: Odontólogos Docentes de Odontologia Planejamento de Assistência ao Paciente Doenças Periodontais/diagnóstico [Mh] Termos MeSH secundário: Odontólogos/estatística & dados numéricos Docentes de Odontologia/estatística & dados numéricos Necessidades e Demandas de Serviços de Saúde Seres Humanos Indiana Doenças Periodontais/terapia Faculdades de Odontologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 180303 [St] Status: MEDLINE [do] DOI: 10.21815/JDE.018.029

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[PMID]: 29346448 [Au] Autor: Stella JL; Bauer AE; Croney CC [Ad] Endereço: USDA-APHIS, Purdue University, W. Lafayette, Indiana, United States of America. [Ti] Título: A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois. [So] Source: PLoS One;13(1):e0191395, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The objectives of this cross-sectional study were: 1) to estimate the prevalence and characterize the severity of periodontal disease in a population of dogs housed in commercial breeding facilities; 2) to characterize PD preventive care utilized by facility owners; and 3) to assess inter-rater reliability of a visual scoring assessment tool. Adult dogs (N = 445) representing 42 breeds at 24 CB facilities in Indiana and Illinois were assessed. Periodontal disease was scored visually using the American Veterinary Dental Collage 0-IV scale. Inter-rater reliability was assessed on 198 dogs and facility owners were asked to provide information about the preventive care utilized. The overall prevalence of periodontal disease (Grades I-IV) was 86.3% (95% CI: 82.9, 89.3). An ordered logistic regression analysis found age (OR = 1.4; 95% CI 1.24, 1.54; P<0.0001), facility (OR = 1.13; 95% CI 1.09, 1.18; P<0.0001), sex (OR = 1.7; 95% CI 1.12, 2.65; P = 0.013), and non-professional dental scaling (OR = 2.82; 95% CI 1.34, 5.91; P = 0.006) to be statistically significant. Inter-rater reliability analysis found agreement to be 86.2%, with a weighted kappa of 0.4731 (95% CI 0.3847, 0.5615) indicating moderate agreement. Risk of periodontal disease increased with increasing age. Additionally, a trend toward decreasing risk with increasing weight was also found, although it was not statistically significant. The trends identified agree with studies that have evaluated periodontal disease in the companion dog population and do not support the assumption that the dental health of dogs in commercial breeding facilities is worse than that of the population as a whole. Although there were few cases of severe periodontal disease and all facilities employed some type of preventive care in this sample, the large number of dogs with some degree of disease (Grades I-IV) suggests that further investigation of preventive care is warranted. [Mh] Termos MeSH primário: Cruzamento Doenças do Cão/epidemiologia Doenças Periodontais/veterinária [Mh] Termos MeSH secundário: Animais Estudos Transversais Cães Feminino Illinois/epidemiologia Indiana/epidemiologia Modelos Logísticos Masculino Doenças Periodontais/epidemiologia Prevalência [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180309 [Lr] Data última revisão: 180309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180119 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191395

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[PMID]: 29203739 [Au] Autor: Berezniakova AI; Cheremisina VF [Ad] Endereço: National Pharmaceutical University, Kharkov, Ukraine. [Ti] Título: 4 and 6 interleukin's action in the pathogenesis of periodontitis, gingivitis and dental alveolitis. [So] Source: Wiad Lek;70(5):910-912, 2017. [Is] ISSN: 0043-5147 [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: INTRODUCTION: The paper presents the results of studying the role of interleukins 4 and 6 in the pathogenesis of periodontal tissue diseases, specifically, in periodontitis, gingivitis and alveolitis. THE AIM: To study the nature of participation of IL-4 and IL-6 in the mechanisms of development of periodontitis, gingivitis and alveolitis. MATERIALS AND METHODS: Studies were carried out on 80 nonlinear male rats with a body weight of 200.0 to 220.0 g divided into four groups of 20 animals each. The serum level of cytokines was determined by an enzyme immunoassay on the Multiscane Biotech analyzer using test systems manufactured by Caltag laboratories (USA). Statistical processing of the obtained digital results was processed with the help of the program "Statistica 8.0". Indicators of the reliability of changes between the control and intact groups also used the Student's test and the Excel program. The confidence level was taken at p <0.05. RESULTS: As a result of our experiments, noticeable changes in the anti-inflammatory cytokine IL-4 were observed in rats with experimental periodontitis. The level of IL-4 cytokine in rats with alveolitis did not differ from control. The level of proinflammatory cytokine IL-6 from all groups of animals with periodontal disease differed from control only in rats with gingivitis, where it decreased by 74% and its level became less with alveolitis and periodontitis, since in these diseases the level of IL-6 was practically the same from the control (p <0,05). We also succeeded in revealing that at a low level of profibrogenic IL-6, there is not enough stimulation of collagen synthesis in the periodontal bone tissue. The increased level of IL-4 in a group of animals with gingivitis, on the contrary, indicates the realization of a pathological reaction of the organism. CONCLUSIONS: The change in the levels of pro- and anti-inflammatory interleukins, especially with gingivitis, indicates a decrease in the body's adaptive reserves and may affect the further dynamics of the inflammatory process in the periodontal tissues. [Mh] Termos MeSH primário: Processo Alveolar/imunologia Gengivite/imunologia Interleucina-4/sangue Interleucina-6/sangue Doenças Periodontais/imunologia [Mh] Termos MeSH secundário: Animais Modelos Animais de Doenças Técnicas Imunoenzimáticas Masculino Ratos Ratos Wistar [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Interleukin-6); 207137-56-2 (Interleukin-4) [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171206 [St] Status: MEDLINE

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[PMID]: 29364329 [Au] Autor: Musskopf ML; Milanesi FC; Rocha JMD; Fiorini T; Moreira CHC; Susin C; Rösing CK; Weidlich P; Oppermann RV [Ad] Endereço: Department of Periodontology, Faculty of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. [Ti] Título: Oral health related quality of life among pregnant women: a randomized controlled trial. [So] Source: Braz Oral Res;32:e002, 2018. [Is] ISSN: 1807-3107 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: The aim of the present study was to compare negative impacts of oral conditions in Oral Heath Related Quality of Life (OHRQoL) assessed by the Oral Health Impact Profile-14 (OHIP-14) scores in pregnant women receiving or not comprehensive periodontal treatment. This randomized controlled clinical trial included pregnant women aged between 18 and 35 years old. Participants were randomized in a test group with 96 and a control group with 114 women. Patients in the test group received comprehensive periodontal treatment, supra and subgingival scaling and root-planning and periodontal maintenance appointments. The OHIP-14 was applied before and after treatment. The primary outcome was changes in OHIP-14 scores after follow-up period. The impact of having received or not comprehensive periodontal treatment on the change of the OHIP-14 scores was also investigated. Both groups showed significant reduction in OHIP-14 scores and effect size for the test group was 0.60 and 0.36 for the control group. Multinomial logistic regression analysis showed that participants of the control group had 5.9-fold odds (CI 95% 1.88-18.52) of worsening in OHIP-14 scores and their perception of oral conditions in relation to test group. Comprehensive periodontal treatment during pregnancy can reduce the negative impacts in OHRQoL. [Mh] Termos MeSH primário: Saúde Bucal/estatística & dados numéricos Doenças Periodontais/terapia Complicações na Gravidez/terapia Qualidade de Vida [Mh] Termos MeSH secundário: Adulto Índice de Placa Dentária Feminino Nível de Saúde Seres Humanos Modelos Logísticos Índice Periodontal Gravidez Cuidado Pré-Natal Perfil de Impacto da Doença Fatores Socioeconômicos Inquéritos e Questionários Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180307 [Lr] Data última revisão: 180307 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 180125 [St] Status: MEDLINE

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[PMID]: 28453689 [Au] Autor: Maisonneuve P; Amar S; Lowenfels AB [Ad] Endereço: Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy. [Ti] Título: Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis. [So] Source: Ann Oncol;28(5):985-995, 2017 05 01. [Is] ISSN: 1569-8041 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Background: Periodontal disease (PD), now our commonest infectious disorder leads to tooth loss, and has been linked to various systemic diseases, including various types of cancer. The aim of this study is to provide a systematic review and a meta-analysis of the relationship between PD, edentulism, and pancreatic cancer (PC). Patients and methods: From an initial review of 327 references we selected eight studies concerning periodontitis or edentulism with sufficient quantitative information to allow us to examine the risk of PC. We used relative risks (RRs), hazard ratios, or odds ratios to measure the association between periodontitis, edentulism, and PC. We employed random effects models to obtain summary risks, and we also provide measures of study differences and possible biases. Results: The summary RR for periodontitis and PC was 1.74 [95% confidence interval (CI) 1.41-2.15] and 1.54 for edentulism (95% CI 1.16-2.05). There was no evidence of heterogeneity for either variable, and no evidence of publication bias. The studies included reports from three continents, suggesting that the association is generalizable. Most of the studies were adjusted for variables thought to be associated with PC, such as gender, smoking, BMI, diabetes, and alcohol. Conclusions: Using meta-analysis, both periodontitis and edentulism appear to be associated with PC, even after adjusting for common risk factors. As yet, the mechanisms linking oral disease and PC are uncertain, but could be related to changes in the oral microbiome-an area of current research. [Mh] Termos MeSH primário: Neoplasias Pancreáticas/etiologia Doenças Periodontais/complicações Perda de Dente/complicações [Mh] Termos MeSH secundário: Animais Causalidade Seres Humanos Neoplasias Pancreáticas/mortalidade Doenças Periodontais/mortalidade Modelos de Riscos Proporcionais Fatores de Risco Perda de Dente/mortalidade [Pt] Tipo de publicação: JOURNAL ARTICLE; META-ANALYSIS; REVIEW [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170429 [St] Status: MEDLINE [do] DOI: 10.1093/annonc/mdx019

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[PMID]: 29351551 [Au] Autor: Pérez Barrionuevo AM; Gómez Real F; Igland J; Johannessen A; Omenaas E; Franklin KA; Pérez Barrionuevo L; Åstrøm AN; Svanes C; Bertelsen RJ [Ad] Endereço: Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. [Ti] Título: Periodontal health status and lung function in two Norwegian cohorts. [So] Source: PLoS One;13(1):e0191410, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE AND OBJECTIVES: The oral cavity is united with the airways, and thus poor oral health may affect respiratory health. However, data on the interaction of periodontal and respiratory health is limited. We aimed to evaluate whether periodontal health status, assessed by the Community Periodontal Index (CPI), was related to lung function among young and middle-aged adults in two Norwegian cohorts. METHODS: Periodontal health status and lung function were measured among 656 participants in the Norwegian part of the European Community Respiratory Health Survey (ECHRS III) and the RHINESSA offspring study. Each participant was given a CPI-index from 0 to 4 where higher values reflect poorer periodontal status. The association between CPI and lung function was estimated with linear regression adjusting for age, gender, smoking, body mass index, exercise, education, use of antibiotics, inhaled medication and corrected for clustering within families. MAIN RESULTS: Participants with CPI 3-4 had significantly lower FEV1/FVC ratio compared to participants with CPI 0, b (95% CI) = -0.032 (-0.055, -0.009). Poorer periodontal health was associated with a significant decrease in the FEV1/FVC ratio with an adjusted regression coefficient for linear trend b (95% CI) = -0.009 (-0.015, -0.004) per unit increase in CPI. This negative association remained when excluding asthmatics and smokers (-0.014 (-0.022, -0,006)). CONCLUSIONS: Poorer periodontal health was associated with increasing airways obstruction in a relatively young, healthy population. The oral cavity is united with the airways and our findings indicate an opportunity to influence respiratory health by improving oral health. [Mh] Termos MeSH primário: Pulmão/fisiologia Saúde Bucal Índice Periodontal [Mh] Termos MeSH secundário: Adulto Estudos de Coortes Estudos Transversais Feminino Volume Expiratório Forçado Nível de Saúde Inquéritos Epidemiológicos Seres Humanos Modelos Lineares Masculino Meia-Idade Noruega Doenças Periodontais/fisiopatologia Capacidade Vital Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180120 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191410

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[PMID]: 29367523 [Au] Autor: Umeda N; Matsumoto I; Sumida T [Ad] Endereço: Department of Rheumatology, Tsuchiura Kyodo General Hospital. [Ti] Título: [The pathogenic role of ACPA in rheumatoid arthritis]. [So] Source: Nihon Rinsho Meneki Gakkai Kaishi;40(6):391-395, 2017. [Is] ISSN: 1349-7413 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo:   In rheumatoid arthritis (RA), ACPA (anti-citrullinated protein/peptide antibody) is elevated with high specificity, and clinically, anti-CCP (cyclic citrullinated peptide) antibody is widely used for diagnosis of RA. It is thought ACPAs are produced with genetic background such as HLA-DR, environmental factors such as periodontal disease and smoking, however, the pathogenic role of ACPA in RA has not been elucidated. These were showed immune complexes including ACPA or ACPA itself promoted inflammatory cytokine production such as TNF. PADs (peptidylarginine deiminases) were expressed and citrullinated proteins existed in RA synovium. ACPAs were deposited on the site of citrulline in CD68 positive cells of RA synovium. The damage of bone and cartilage is observed in RA. It was also suggested that deposition of ACPAs caused osteoclastogenesis and bone loss. We introduce several findings about the pathogenic role of ACPA in RA. [Mh] Termos MeSH primário: Anticorpos Anti-Proteína Citrulinada/efeitos adversos Anticorpos Anti-Proteína Citrulinada/imunologia Artrite Reumatoide/imunologia [Mh] Termos MeSH secundário: Antígenos CD Antígenos de Diferenciação Mielomonocítica Artrite Reumatoide/diagnóstico Artrite Reumatoide/metabolismo Artrite Reumatoide/patologia Reabsorção Óssea/imunologia Osso e Ossos/patologia Cartilagem/patologia Citrulina/imunologia Citrulina/metabolismo Antígenos HLA-DR Seres Humanos Mediadores da Inflamação/metabolismo Osteogênese/imunologia Doenças Periodontais Desiminases de Arginina em Proteínas/metabolismo Fumar Membrana Sinovial/citologia Membrana Sinovial/metabolismo Fator de Necrose Tumoral alfa/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Anti-Citrullinated Protein Antibodies); 0 (Antigens, CD); 0 (Antigens, Differentiation, Myelomonocytic); 0 (CD68 antigen, human); 0 (HLA-DR Antigens); 0 (Inflammation Mediators); 0 (Tumor Necrosis Factor-alpha); 29VT07BGDA (Citrulline); EC 3.5.3.15 (Protein-Arginine Deiminases) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180126 [St] Status: MEDLINE [do] DOI: 10.2177/jsci.40.391

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[PMID]: 29384859 [Au] Autor: Wang TF; Fang CH; Hsiao KJ; Chou C [Ad] Endereço: School of Nursing. [Ti] Título: Effect of a comprehensive plan for periodontal disease care on oral health-related quality of life in patients with periodontal disease in Taiwan. [So] Source: Medicine (Baltimore);97(5):e9749, 2018 Feb. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A comprehensive plan for periodontal disease (PD) care in Taiwan provides non-surgical and supportive periodontal treatment. The aim of this study was to determine whether the care plan could improve the oral health-related quality of life of patients with PD.This study was conducted by purposive sampling and a quasi-experimental design. Patients with PD were assigned to either comprehensive periodontal treatment (n = 32) or a simple cleaning regimen (n = 32). Their oral health-related quality of life (OHRQoL) was measured using the Taiwanese version of the Brief World Health Organization Quality of Life (WHOQOL-BREF) scale (general QoL) and the Oral Health Impact Profile (OHIP-14) (OHRQoL). Both scales were completed 14, 28, and 90 days after the initial assessment. The extent of PD in the experimental group was determined again at the end of the study.On the 28-item WHOQOL-BREF scale, the scores of the experimental group were higher than those of the control group on 5 items and the environmental domain at 14 days. There was a significant improvement in the experimental group on 2 items at 28 days and at 90 days after periodontal treatment (both P < .05). No difference was found between the 2 groups in score on the OHIP-14; however, there was a significant improvement in the experimental group in total score at 28 and 90 days after periodontal treatment (both P < .05). The number of teeth with probing depth ≥5 mm and the percentage of dental plaque were both significantly reduced after the intervention (both P < .001).Patients with a comprehensive plan for PD care showed some improvement in QoL, including in the environmental domain, and on the total score for OHRQoL. Comprehensive periodontal treatment also alleviated periodontal symptoms. [Mh] Termos MeSH primário: Assistência Odontológica Saúde Bucal Doenças Periodontais/terapia Qualidade de Vida [Mh] Termos MeSH secundário: Adulto Feminino Seres Humanos Masculino Meia-Idade Índice Periodontal Inquéritos e Questionários Taiwan [Pt] Tipo de publicação: CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180221 [Lr] Data última revisão: 180221 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 180201 [St] Status: MEDLINE [do] DOI: 10.1097/MD.0000000000009749

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[PMID]: 29275574 [Au] Autor: Wang Q; Meng HX [Ad] Endereço: Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China. [Ti] Título: [Research progress in microbiological characteristics of peri-implant disease]. [So] Source: Zhonghua Kou Qiang Yi Xue Za Zhi;52(12):773-776, 2017 Dec 09. [Is] ISSN: 1002-0098 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: Peri-implant disease is an inflammatory status which leads to the destruction of the soft and hard tissues around osseointegrated implants, including peri-implant mucositis and peri-implantitis. It is generally accepted that bacterial infection appears to be responsible for peri-implant lesions. This review aims to summarize the characteristics of the subgingival microbiota in healthy and diseased implants and compare the microbial composition of subgingival biofilm in teeth with periodontal disease and in diseased implant, so as to provide biological basis on the diagnosis, therapy and prevention of peri-implant disease in clinical practice. [Mh] Termos MeSH primário: Biofilmes Implantes Dentários/microbiologia Peri-Implantite/microbiologia Estomatite/microbiologia [Mh] Termos MeSH secundário: Pesquisa em Odontologia Seres Humanos Doenças Periodontais/microbiologia [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Dental Implants) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180209 [Lr] Data última revisão: 180209 [Sb] Subgrupo de revista: D; IM [Da] Data de entrada para processamento: 171226 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.1002-0098.2017.12.012

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[PMID]: 27778343 [Au] Autor: Momen-Heravi F; Babic A; Tworoger SS; Zhang L; Wu K; Smith-Warner SA; Ogino S; Chan AT; Meyerhardt J; Giovannucci E; Fuchs C; Cho E; Michaud DS; Stampfer MJ; Yu YH; Kim D; Zhang X [Ad] Endereço: Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA. [Ti] Título: Periodontal disease, tooth loss and colorectal cancer risk: Results from the Nurses' Health Study. [So] Source: Int J Cancer;140(3):646-652, 2017 Feb 01. [Is] ISSN: 1097-0215 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Periodontal diseases including tooth loss might increase systemic inflammation, lead to immune dysregulation and alter gut microbiota, thereby possibly influencing colorectal carcinogenesis. Few epidemiological studies have examined the association between periodontal diseases and colorectal cancer (CRC) risk. We collected information on the periodontal disease (defined as history of periodontal bone loss) and number of natural teeth in the Nurses' Health Study. A total of 77,443 women were followed since 1992. We used Cox proportional hazard models to calculate multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) after adjustment for smoking and other known risk factors for CRC. We documented 1,165 incident CRC through 2010. Compared to women with 25-32 teeth, the multivariable HR (95% CI) for CRC for women with <17 teeth was 1.20 (1.04-1.39). With regard to tumor site, the HRs (95% CIs) for the same comparison were 1.23 (1.01-1.51) for proximal colon cancer, 1.03 (0.76-1.38) for distal colon cancer and 1.48 (1.07-2.05) for rectal cancer. In addition, compared to those without periodontal disease, HRs for CRC were 0.91 (95% CI 0.74-1.12) for periodontal disease, and 1.22 (95% CI 0.91-1.63) when limited to moderate to severe periodontal disease. The results were not modified by smoking status, body mass index or alcohol consumption. Women with fewer teeth, possibly moderate or severe periodontal disease, might be at a modest increased risk of developing CRC, suggesting a potential role of oral health in colorectal carcinogenesis. [Mh] Termos MeSH primário: Neoplasias Colorretais/etiologia Doenças Periodontais/complicações Perda de Dente/complicações [Mh] Termos MeSH secundário: Consumo de Bebidas Alcoólicas/efeitos adversos Estudos Epidemiológicos Feminino Seres Humanos Meia-Idade Modelos de Riscos Proporcionais Estudos Prospectivos Fatores de Risco Fumar/efeitos adversos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 180201 [Lr] Data última revisão: 180201 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161026 [St] Status: MEDLINE [do] DOI: 10.1002/ijc.30486

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3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde