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[PMID]:28422590
[Au] Autor:Kalogirou EM; Chatzidimitriou K; Tosios KI; Piperi EP; Sklavounou A
[Ti] Título:Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases.
[So] Source:J Clin Pediatr Dent;41(3):228-231, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a painless gingival swelling that histologically exhibits hyperplasia of the non-keratinized stratified squamous epithelium, intercellular edema and spongiosis of the spinus layer, and exocytosis of inflammatory cells. LJSGH pathogenesis remains to be elucidated, while a possible origin from the gingival sulcus epithelium is nowadays proposed. STUDY DESIGN: We report two cases of LJSGH with immunohistochemical evaluation of cytokeratins (CKs) 18 and 19. RESULTS: Both cases concerned 12-year-old boys, who presented with a well-circumscribed bright red pedunculated papillary swelling on the marginal gingiva of the left maxillary lateral incisor. With the provisional diagnosis of LJSGH, the lesions were excised under local anesthesia and histological examination supported the final diagnosis of LJSGH. In both cases, the lesional epithelium showed intense and mild positivity for CK19 and CK18, respectively, while the adjacent normal gingival epithelium expressed CK19, but not CK18, only in the basal cell layer. The postoperative course was uneventful in both patients and no recurrence has been reported. CONCLUSION: LJSGH is a recently introduced entity that is worth attention in the clinical pediatric dentistry. Clinical and histological examination is required for the final diagnosis, while immunohistochemistry has shed light to LJSGH pathogenesis.
[Mh] Termos MeSH primário: Hiperplasia Gengival/patologia
[Mh] Termos MeSH secundário: Criança
Hiperplasia Gengival/cirurgia
Gengivectomia/métodos
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.3.228


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[PMID]:28414538
[Au] Autor:Critchlow D
[Ad] Endereço:Senior Dental Officer, Northeast London NHS Foundation Trust, Dental Department, Grays Health Centre.
[Ti] Título:Part 3: Impact of systemic conditions and medications on oral health.
[So] Source:Br J Community Nurs;22(4):181-190, 2017 Apr 02.
[Is] ISSN:1462-4753
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The people who are treated in the community setting will often have multiple comorbidities. Systemic medical conditions can have a negative impact on oral health. In addition, the medications used to treat systemic conditions may also themselves cause oral symptoms. As a large proportion of patients treated by the community nursing team will be elderly, this paper will focus on common geriatric conditions that can display oral or dental symptoms. The effects of medications will be discussed and linked to oral complaints patients may express. The primary aims are to give a broad overview of the oral effects of ageing, of illness and of polypharmacy and advise on how these can be best managed by the nursing team.
[Mh] Termos MeSH primário: Envelhecimento
Enfermagem em Saúde Comunitária
Doenças da Boca/enfermagem
Saúde Bucal
[Mh] Termos MeSH secundário: Deficiência de Vitaminas/complicações
Deficiência de Vitaminas/enfermagem
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/etiologia
Osteonecrose da Arcada Osseodentária Associada a Difosfonatos/enfermagem
Demência/epidemiologia
Demência/enfermagem
Diabetes Mellitus/epidemiologia
Diabetes Mellitus/enfermagem
Hiperplasia Gengival/epidemiologia
Hiperplasia Gengival/enfermagem
Seres Humanos
Desnutrição/complicações
Desnutrição/enfermagem
Doenças da Boca/epidemiologia
Doenças da Boca/etiologia
Úlceras Orais/epidemiologia
Úlceras Orais/etiologia
Úlceras Orais/enfermagem
Doença de Parkinson/epidemiologia
Doença de Parkinson/enfermagem
Polimedicação
Fatores de Risco
Síndrome de Sjogren/complicações
Síndrome de Sjogren/enfermagem
Distúrbios do Paladar/epidemiologia
Distúrbios do Paladar/enfermagem
Xerostomia/induzido quimicamente
Xerostomia/etiologia
Xerostomia/enfermagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170418
[St] Status:MEDLINE
[do] DOI:10.12968/bjcn.2017.22.4.181


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[PMID]:28137906
[Au] Autor:Kirpalani A; Rieder MJ; Bax KC; Filler G
[Ad] Endereço:Department of Paediatrics, University of Western Ontario, London, Ontario, Canada.
[Ti] Título:Idiosyncratic drug reactions and membranous glomerulopathy.
[So] Source:BMJ Case Rep;2017, 2017 Jan 30.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An infant boy with steroid-resistant nephrotic syndrome (idiopathic membranous glomerulonephropathy) achieved remission with ciclosporin but developed eosinophilia and high IgE levels (max 19 000  iU/mL). Conversion to tacrolimus resulted in chronic diarrhoea (eosinophilic gastroenteritis), muscle weakness, polyserositis and failure-to-thrive. In contrast, a trial without tacrolimus resulted in a ciclosporin-responsive relapse, therapy-resistant focal seizures with generalised spikes, worsening muscle weakness and diarrhoea. The patient was weaned off of ciclosporin and completely normalised. In vitro testing demonstrated decreased viability of the patient's cells when incubated with calcineurin inhibitors (ciclosporin, 70%; tacrolimus, 80% compared to control cells), supporting their role in this adverse drug reaction.
[Mh] Termos MeSH primário: Ciclosporina/efeitos adversos
Enterite/induzido quimicamente
Eosinofilia/induzido quimicamente
Gastrite/induzido quimicamente
Glomerulonefrite Membranosa/tratamento farmacológico
Imunossupressores/efeitos adversos
Convulsões/induzido quimicamente
Tacrolimo/efeitos adversos
Vasculite/induzido quimicamente
[Mh] Termos MeSH secundário: Sobrevivência Celular
Desprescrições
Substituição de Medicamentos
Insuficiência de Crescimento/induzido quimicamente
Hiperplasia Gengival/induzido quimicamente
Glomerulonefrite Membranosa/diagnóstico
Glomerulonefrite Membranosa/patologia
Seres Humanos
Hipertricose/induzido quimicamente
Técnicas In Vitro
Lactente
Glomérulos Renais/ultraestrutura
Masculino
Microscopia Eletrônica
Debilidade Muscular/induzido quimicamente
Serosite/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents); 83HN0GTJ6D (Cyclosporine); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE


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[PMID]:29045773
[Au] Autor:Levarda-Hudolin K; Hudolin T; Basic-Jukic N; Kastelan Z
[Ti] Título:ORAL LESIONS IN KIDNEY TRANSPLANT RECIPIENTS.
[So] Source:Acta Clin Croat;55(3):459-63, 2016 09.
[Is] ISSN:0353-9466
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Permanent immunosuppression is necessary to prevent rejection after kidney transplantation. However, it may predispose patients to different conditions and diseases including oral lesions. The most common benign oral lesions in kidney transplant recipients are gingival hyperplasia, oral candidiasis, hairy leukoplakia and saburral tongue. Oral form of Kaposi sarcoma, although rarely, can also be seen in kidney transplant patients. In this review, we present the incidence, etiology, clinical findings, diagnosis and treatment options for these lesions. For kidney transplant recipients, it is important to maintain good oral hygiene and care, as well as regular professional control by the dentist. This approach can reduce the number and severity of oral lesions.
[Mh] Termos MeSH primário: Bloqueadores dos Canais de Cálcio/efeitos adversos
Candidíase Bucal/etiologia
Imunossupressores/efeitos adversos
Transplante de Rim/efeitos adversos
Leucoplasia Pilosa/etiologia
Doenças da Boca/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Hiperplasia Gengival/induzido quimicamente
Seres Humanos
Masculino
Meia-Idade
Higiene Bucal
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Calcium Channel Blockers); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE


  5 / 1562 MEDLINE  
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Lopes, Márcio Ajudarte
Vargas, Pablo Agustin
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[PMID]:27729142
[Au] Autor:Ataíde AP; Fonseca FP; Santos Silva AR; Jorge Júnior J; Lopes MA; Vargas PA
[Ad] Endereço:Department of Oral Diagnosis, Oral Pathology and Semiology Divisions, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil. Electronic address: aline.ataide@yahoo.com.br.
[Ti] Título:Distribution of oral and maxillofacial lesions in pediatric patients from a Brazilian southeastern population.
[So] Source:Int J Pediatr Otorhinolaryngol;90:241-244, 2016 Nov.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Oral lesions affecting infants account for approximately 10% of all samples from diagnostic services and studies investigating the distribution of these lesions in pediatrics from different geographic areas are desired to improve the diagnostic knowledge of clinicians. Therefore, the aim of this study is to describe the distribution of oral lesions in a southeastern Brazilian population. METHODS: The oral pathology files of the University of Campinas was retrospectively reviewed for all cases diagnosed from 2000 to 2014 affecting patients 16-years-old and younger. Data on gender and diagnosis were retrieved from patients' oral pathology reports and included in a Microsoft Excel database. RESULTS: Out of 34,138 cases, 2539 affected pediatric patients (7.4%) with a higher incidence in those with 13-16 years-old. Salivary gland disease was the most common group of lesions (37.1%), followed by mucosal pathology (13.6%) and odontogenic cysts (11.3%). Mucous extravasation cyst was the most common lesion (36.3%), followed by fibrous hyperplasia (5.6%) and dental follicle (5.2%). Dental lesions were uncommon (7.9%) and malignancies rare (0.4%). CONCLUSIONS: Our results were similar to previous studies and the small differences observed were more likely result of methodological variability and characteristics of the service of origin from where samples were collected.
[Mh] Termos MeSH primário: Doenças da Boca/epidemiologia
Mucocele/epidemiologia
Cistos Odontogênicos/epidemiologia
Doenças das Glândulas Salivares/epidemiologia
[Mh] Termos MeSH secundário: Distribuição por Idade
Brasil/epidemiologia
Criança
Pré-Escolar
Saco Dentário
Feminino
Hiperplasia Gengival/epidemiologia
Seres Humanos
Hiperplasia
Incidência
Lactente
Recém-Nascido
Masculino
Neoplasias Bucais/epidemiologia
Tumores Odontogênicos/epidemiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


  6 / 1562 MEDLINE  
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[PMID]:27305299
[Au] Autor:Michels G; Pfister R
[Ti] Título:[71-year old woman with arterial hypertension and oral finding].
[Ti] Título:71-jährige Frau mit Bluthochdruck und unklarem oralem Befund..
[So] Source:Dtsch Med Wochenschr;141(12):855, 2016 Jun.
[Is] ISSN:1439-4413
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Anlodipino/efeitos adversos
Hiperplasia Gengival/induzido quimicamente
Hipertensão/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Anlodipino/uso terapêutico
Diagnóstico Diferencial
Substituição de Medicamentos
Feminino
Seres Humanos
Piperazinas/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Piperazines); 1J444QC288 (Amlodipine); A78GF17HJS (urapidil)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160616
[St] Status:MEDLINE
[do] DOI:10.1055/s-0041-110228


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[PMID]:27259395
[Au] Autor:Sibaud V; Vigarios E; Tavitian S; Cougoul P; de Bataille C; Campana F; Fricain JC
[Ad] Endereço:Oncodermatologie, consultation pluridisciplinaire de pathologies de la muqueuse buccale, institut Claudius-Regaud, institut universitaire du cancer, Toulouse oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France. Electronic address: sibaud.vincent@iuct-oncopole.fr.
[Ti] Título:[Gingival enlargement: Practical management].
[Ti] Título:Accroissements gingivaux : approche pragmatique..
[So] Source:Ann Dermatol Venereol;143(6-7):467-81, 2016 Jun-Jul.
[Is] ISSN:0151-9638
[Cp] País de publicação:France
[La] Idioma:fre
[Mh] Termos MeSH primário: Hiperplasia Gengival/diagnóstico
Hipertrofia Gengival/diagnóstico
[Mh] Termos MeSH secundário: Algoritmos
Fibromatose Gengival/diagnóstico
Fibromatose Gengival/etiologia
Hiperplasia Gengival/etiologia
Hipertrofia Gengival/etiologia
Granuloma/diagnóstico
Granuloma/etiologia
Granulomatose Orofacial/diagnóstico
Granulomatose Orofacial/etiologia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  8 / 1562 MEDLINE  
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[PMID]:27222632
[Au] Autor:Nidhi C; Anuj C
[Ad] Endereço:Department of Pedodontics & Preventive Dentistry, Maulana Azad Institute of Dental Sciences, Delhi, India.
[Ti] Título:Sturge Weber Syndrome: An Unusual Case with Multisystem Manifestations.
[So] Source:Ethiop J Health Sci;26(2):187-92, 2016 Mar.
[Is] ISSN:2413-7170
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Sturge-Weber syndrome (SWS) is a rare congenital neurocutaneous disorder. It is characterized by the presence of facial port wine stains, neurological abnormalities like seizures and mental retardation, ocular disorders, oral involvement and leptomeningeal angiomas. CASE REPORT: A 13-year-old boy presented with the chief complaint of swollen, bleeding gums and deposits on the teeth. Detailed medical and dental history, clinical examination and investigations confirmed the diagnosis of Sturge-Weber syndrome. The treatment comprised of a thorough plaque control regimen to reduce the gingival enlargement, and it included oral hygiene instructions, thorough scaling, root planing at regular intervals and plaque index scoring which motivated the patient at each visit. CONCLUSION: This case illustrates that early intervention in a patient with Sturge-Weber syndrome is quintessential because of its associated gingival vascular features and their complicating manifestations. Furthermore, the need for periodic oral examinations and maintenance of good oral hygiene to prevent any complications from the oral vascular lesions has been highlighted.
[Mh] Termos MeSH primário: Gengiva/fisiopatologia
Hiperplasia Gengival/etiologia
Hiperplasia Gengival/terapia
Mancha Vinho do Porto/etiologia
Síndrome de Sturge-Weber/complicações
Síndrome de Sturge-Weber/terapia
[Mh] Termos MeSH secundário: Adolescente
Seres Humanos
Masculino
Síndrome de Sturge-Weber/diagnóstico
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160526
[St] Status:MEDLINE


  9 / 1562 MEDLINE  
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[PMID]:27174195
[Au] Autor:Krejci K; Zadrazil J; Lackova E; Zilinska Z; Roland R; Dedinska I
[Ad] Endereço:Department of Internal Medicine III - Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Czech Republic.
[Ti] Título:Clinical experience of conversion from cyclosporine to tacrolimus prolonged-release in stabilized kidney transplant patients.
[So] Source:Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub;160(3):407-11, 2016 Sep.
[Is] ISSN:1213-8118
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: The CONCERTO study results showing the beneficial effects of conversion from cyclosporine to tacrolimus prolonged-release (tacrolimus PR) in stabilised patients after kidney transplantation, were first published in 2011. This communication describes our first experience of conversion from cyclosporine to tacrolimus PR in stabilised kidney transplant patients. The aim was to determine whether it could be used in routine clinical practice in the Czech and Slovak Republics. METHODS: Evaluation was carried out at five transplantation centres in the Czech Republic and Slovakia. In all participating Centres, the drug conversion was conducted according to the ICH/GCP guidelines. A total of 104 patients stabilised after kidney transplantation were converted from maintenance therapy with cyclosporine to treatment with tacrolimus PR. The data were collected 26 weeks after the switch. The primary endpoint was change in kidney graft function measured from the estimated glomerular filtration rate (GFR). The effect of conversion on blood pressure, metabolic parameters and cosmetic changes was also recorded. Special attention was paid to the safety and tolerability of treatment with tacrolimus PR. RESULTS: GFR increased after six months by 10 % (P = 0.040). In addition a significant decrease in serum creatinine and triglycerides level was found together with major reduction in the incidence and severity of gingival hyperplasia and hirsutism. 3% of patients developed new onset of diabetes mellitus. Otherwise, the switch was very well-tolerated, without serious adverse events or acute rejections. CONCLUSION: Conversion from cyclosporine to tacrolimus PR was shown to be a safe therapeutic alternative with patient benefits.
[Mh] Termos MeSH primário: Ciclosporina/administração & dosagem
Imunossupressores/administração & dosagem
Transplante de Rim
Tacrolimo/administração & dosagem
[Mh] Termos MeSH secundário: Preparações de Ação Retardada
Nefropatias Diabéticas/fisiopatologia
Relação Dose-Resposta a Droga
Substituição de Medicamentos
Dislipidemias/etiologia
Feminino
Hiperplasia Gengival/etiologia
Taxa de Filtração Glomerular/efeitos dos fármacos
Hirsutismo/etiologia
Seres Humanos
Hipertensão Renal/etiologia
Nefropatias/cirurgia
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Delayed-Action Preparations); 0 (Immunosuppressive Agents); 83HN0GTJ6D (Cyclosporine); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.5507/bp.2016.026


  10 / 1562 MEDLINE  
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[PMID]:27149498
[Au] Autor:Monea M; Moldovan C
[Ad] Endereço:From the Department of Odontology and Oral Pathology (MM), Faculty of Dental Medicine; and Department of Histology (CM), Faculty of Medicine, University of Medicine and Pharmacy, Tirgu Mures, Romania.
[Ti] Título:Rare Root Morphology of a Maxillary Central Incisor Associated With Gingival Hyperplasia: An Endodontic Case Report.
[So] Source:Medicine (Baltimore);95(18):e3617, 2016 May.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dilaceration is a developmental disturbance characterized by the angulation of the crown or root of a permanent tooth, which is often related to trauma of primary dentition. We report a case of a dilacerated root in a maxillary central incisor associated with gingival hyperplasia in a patient under fixed orthodontic treatment, a combination of pathological conditions that had never been mentioned before in the scientific literature.A 10-year-old female patient presented to the Department of Odontology and Oral Pathology with tenderness to palpation and bleeding from the oral aspect of the central incisor, alerted by the proliferation of the gingiva. During clinical examination, the palpation performed with a dental probe revealed a carious lesion with dental pulp exposure on the distal aspect of right central incisor and the presence of a sessile mass of inflamed gingival tissue that proliferated inside the defect. On the preoperative radiograph a dilacerated root canal was noted, without periapical bone resorption.The main diagnosis was irreversible pulpitis and gingival hyperplasia and the treatment option was surgical removal of the inflamed tissue with histopathological examination and root canal treatment. Successful endodontic treatment with a good prognosis was recorded.The measurement of the root curvature proved to be extremely helpful in choosing the right endodontic technique and made the treatment easier than expected. An important observation was that, despite the rare clinical and radiographic aspect of this dilacerated tooth, the endodontic treatment proved to be relatively easy to perform and, therefore, the prognosis was considered favorable.
[Mh] Termos MeSH primário: Hiperplasia Gengival/complicações
Incisivo
Pulpite/complicações
Raiz Dentária/anormalidades
[Mh] Termos MeSH secundário: Criança
Feminino
Hiperplasia Gengival/cirurgia
Seres Humanos
Maxila
Pulpite/cirurgia
Radiografia Dentária
Tratamento do Canal Radicular
Raiz Dentária/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000003617



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