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  1 / 1756 MEDLINE  
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[PMID]:29188693
[Au] Autor:Chatzistavrianou D; Blair F
[Ti] Título:Diagnosis and Management of Chronic and Aggressive Periodontitis Part 2: Periodontal Management.
[So] Source:Dent Update;44(5):402-4, 407-8, 2017 May.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The first paper of this three-part series discussed periodontal disease pathogenesis and highlighted elements in the clinical assessment which will help the clinician to establish the diagnosis of chronic and aggressive periodontitis. This second paper will focus on the management of chronic and aggressive periodontitis. Finally, the diagnosis and management of chronic and aggressive periodontitis will be reviewed in the third part of the series using two clinical examples. Clinical relevance: This paper aims to provide the general dental practitioner with an understanding of the aim of periodontal treatment, the management of chronic and aggressive periodontitis and the prognosis of periodontally involved teeth.
[Mh] Termos MeSH primário: Periodontite Agressiva/terapia
Periodontite Crônica/terapia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  2 / 1756 MEDLINE  
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[PMID]:29172354
[Au] Autor:Chatzistavrianou D; Blair F
[Ti] Título:Diagnosis and Management of Chronic and Aggressive Periodontitis Part 1: Periodontal Assessment and Diagnosis.
[So] Source:Dent Update;44(4):306-8, 310, 313-5, 2017 Apr.
[Is] ISSN:0305-5000
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:common diseases that affect the oral cavity. The differential diagnosis between chronic and aggressive periodontitis can be complex for some clinicians and the correct diagnosis is a key element in disease management. The three-part series will review periodontal clinical assessment and diagnosis, periodontal management and finally will discuss two clinical cases. This paper will focus on periodontal disease pathogenesis, periodontal clinical assessment and diagnosis. Clinical relevance: This paper aims to provide the general dental practitioner with an understanding of periodontal disease pathogenesis and to highlight elements in the clinical assessment which will help to establish the diagnosis
[Mh] Termos MeSH primário: Periodontite Agressiva/diagnóstico
Periodontite Crônica/diagnóstico
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  3 / 1756 MEDLINE  
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[PMID]:28449029
[Au] Autor:Munz M; Willenborg C; Richter GM; Jockel-Schneider Y; Graetz C; Staufenbiel I; Wellmann J; Berger K; Krone B; Hoffmann P; van der Velde N; Uitterlinden AG; de Groot LCPGM; Sawalha AH; Direskeneli H; Saruhan-Direskeneli G; Guzeldemir-Akcakanat E; Keceli G; Laudes M; Noack B; Teumer A; Holtfreter B; Kocher T; Eickholz P; Meyle J; Doerfer C; Bruckmann C; Lieb W; Franke A; Schreiber S; Nohutcu RM; Erdmann J; Loos BG; Jepsen S; Dommisch H; Schaefer AS
[Ad] Endereço:Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Germany.
[Ti] Título:A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.
[So] Source:Hum Mol Genet;26(13):2577-2588, 2017 07 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted a GWAS using a German and Dutch case-control sample of aggressive periodontitis (AgP, 896 cases, 7,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associations in a German sample of severe forms of the more moderate phenotype chronic periodontitis (CP) (993 cases, 1,419 controls). Positive findings were replicated in a Turkish sample of AgP (223 cases, 564 controls). A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease phenotypes and were associated with periodontitis at a genome-wide significance level in the pooled samples, with P = 1.09E-08 (rs4284742,-G; OR = 1.34, 95% CI = 1.21-1.48) and P = 5.48E-10 (rs2738058,-T; OR = 1.28, 95% CI = 1.18-1.38), respectively. SIGLEC5 is expressed in various myeloid immune cells and classified as an inhibitory receptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling. Alpha defensins are antimicrobial peptides with expression in neutrophils and mucosal surfaces and a role in phagocyte-mediated host defense. This study identifies the first shared genetic risk loci of AgP and CP with genome-wide significance and highlights the role of innate and adaptive immunity in the etiology of periodontitis.
[Mh] Termos MeSH primário: Antígenos CD/genética
Antígenos de Diferenciação Mielomonocítica/genética
Periodontite Crônica/genética
Lectinas/genética
Peptídeos Cíclicos/genética
alfa-Defensinas/genética
[Mh] Termos MeSH secundário: Adulto
Periodontite Agressiva/genética
Antígenos CD/metabolismo
Antígenos de Diferenciação Mielomonocítica/metabolismo
Estudos de Casos e Controles
Feminino
Loci Gênicos
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Genótipo
Seres Humanos
Lectinas/metabolismo
Masculino
Meia-Idade
Nucleotídeos
Peptídeos Cíclicos/metabolismo
Fenótipo
Polimorfismo de Nucleotídeo Único/genética
Fatores de Risco
Turquia
alfa-Defensinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Antigens, Differentiation, Myelomonocytic); 0 (DEFA1A3 protein, human); 0 (Lectins); 0 (Nucleotides); 0 (Peptides, Cyclic); 0 (SIGLEC5 protein, human); 0 (alpha-Defensins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180110
[Lr] Data última revisão:
180110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx151


  4 / 1756 MEDLINE  
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[PMID]:29036216
[Au] Autor:Li F; Zhu C; Deng FY; Wong MCM; Lu HX; Feng XP
[Ad] Endereço:Department of Preventive Dentistry, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, China.
[Ti] Título:Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies.
[So] Source:PLoS One;12(10):e0186373, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP). However, these findings are controversial. This meta-analysis was aimed at clarifying the association between herpesviruses and AgP. METHODS: We identified eligible case-control studies evaluating the association between herpesviruses and AgP from PubMed and Embase databases in October 2015. Original data were extracted and quality assessment was done. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Random-effects model was determined. The stability was evaluated by sensitivity analysis. Finally, Egger's funnel plot was used to investigate the publication bias. RESULTS: Twelve case-control studies involving 322 patients and 342 controls were included in the present meta-analysis. The included case-control studies were assessed as high quality. The quantitative synthesis results for Epstein-Barr virus (EBV) showed significance (10 studies: p = 0.0008, OR = 6.11, 95% CI = 2.13-17.51); nevertheless, evidence of publication bias for EBV was considerable (EBV: Egger's test, p<0.001). Human cytomegalovirus (HCMV) and Herpes simplex virus type 1 (HSV-1) had significant association with AgP (12 studies for HCMV: p = 0.009, OR = 3.63, 95% CI = 2.15-6.13; 4 studies for HSV-1: p<0.001, OR = 19.19, 95% CI = 4.16-79.06). Sensitivity analyses showed the results yielded consistency, and no significant publication bias was observed for HCMV. The association between Herpes simplex virus type 2 (HSV-2) and AgP was inconclusive (2 studies: p = 0.20, OR = 3.46, 95% CI = 0.51-23.51). CONCLUSION: This meta-analysis suggests that HCMV and HSV-1 are significantly associated with AgP. However, due to the heterogeneity among studies these conclusions should be cautiously interpreted. There is insufficient evidence to draw any conclusion between EBV, HSV-2 and AgP based on the currently limited data.
[Mh] Termos MeSH primário: Periodontite Agressiva/etiologia
Periodontite Agressiva/virologia
Herpesviridae/fisiologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171017
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186373


  5 / 1756 MEDLINE  
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[PMID]:29023524
[Au] Autor:Mesa F; Lanza E; García L; Marfil-Alvarez R; Magan-Fernandez A
[Ad] Endereço:Periodontology Department, School of Dentistry, University of Granada, Granada, Spain.
[Ti] Título:Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.
[So] Source:PLoS One;12(10):e0186366, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and ß and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the load of five periodontopathogenic bacteria and periodontal clinical variables. A cross-sectional analytic study was conducted in 123 patients with GCP, 60 patients with GAgP, and 20 controls. Reverse hybridization PCR was used for genotyping analysis to detect SNPs in IL-1A (rs1800587), IL-1B (rs1143634), and IL-1RN (rs419598) genes and for determination of the load of five periodontopathogenic bacteria. The severity and extension of periodontitis were assessed. Multinomial logistic regression and mediated regression analyses were performed. Considering results for GCP and GAgP patients together, the presence of polymorphism in IL-1A and/or IL-1B gene was associated with a higher likelihood of periodontitis, (OR = 8.11; 95%CI [1.85-35.48]), but this likelihood was reduced when IL-1RN polymorphism was also present, (OR = 5.91; 95%CI [1.08-32.27]). IL-1RN polymorphism was significantly associated with lower counts of red complex bacteria, specifically Porphyromona gingivalis, Tannerella forsythia, and Prevotella intermedia, which were associated with improved clinical outcomes. The polymorphic expression of IL-1RN (rs419598) gene may be associated with a reduced susceptibility to GAgP and GCP in populations of European descent. This effect may be mediated by a decreased load of Porphyromona gingivalis, Tannerella forsythia, and Prevotella intermedia.
[Mh] Termos MeSH primário: Periodontite Crônica/genética
Grupo com Ancestrais do Continente Europeu/genética
Proteína Antagonista do Receptor de Interleucina 1/genética
[Mh] Termos MeSH secundário: Adulto
Periodontite Agressiva/genética
Periodontite Agressiva/microbiologia
Periodontite Agressiva/patologia
Alelos
Estudos de Casos e Controles
Periodontite Crônica/microbiologia
Periodontite Crônica/patologia
Estudos Transversais
Feminino
Genótipo
Seres Humanos
Interleucina-1alfa/genética
Interleucina-1beta/genética
Modelos Logísticos
Masculino
Meia-Idade
Polimorfismo de Nucleotídeo Único/genética
Porphyromonas gingivalis/genética
Porphyromonas gingivalis/isolamento & purificação
Porphyromonas gingivalis/fisiologia
Prevotella intermedia/genética
Prevotella intermedia/isolamento & purificação
Prevotella intermedia/fisiologia
RNA Ribossômico 16S/genética
RNA Ribossômico 16S/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin 1 Receptor Antagonist Protein); 0 (Interleukin-1alpha); 0 (Interleukin-1beta); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186366


  6 / 1756 MEDLINE  
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[PMID]:28817589
[Au] Autor:Tada S; Ikebe K; Kamide K; Gondo Y; Inomata C; Takeshita H; Matsuda KI; Kitamura M; Murakami S; Kabayama M; Oguro R; Nakama C; Kawai T; Yamamoto K; Sugimoto K; Shintani A; Ishihara T; Arai Y; Masui Y; Takahashi R; Rakugi H; Maeda Y
[Ad] Endereço:Department of Oral Health Science, Division of Preventive Dentistry, Niigata University Graduate School of Medical and Dental Science, Niigata, Niigata, Japan.
[Ti] Título:Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study.
[So] Source:PLoS One;12(8):e0182563, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Whereas most of studies investigating relationship between oral health and atherosclerosis have focused on periodontitis, very few of them were examined about occlusal status of natural teeth which possibly influence dietary habit. The primary aim of this cross-sectional study was to investigate the association between the occlusal support of posterior teeth and the prevalence of atherosclerosis in community-dwelling septuagenarians. Also, the second aim was to test the hypothesis that the intake of key nutrients for atherosclerosis prevention would have a mediating effect on the relationship between the occlusal status and atherosclerosis. The study population included 468 community-dwelling dentate persons aged 69-71 years recruited from the local residential registration in Japan. Participants were divided into three groups, according to the number of occlusal support zones (OSZ) in the posterior area: Complete (four OSZ), Moderate (three or two OSZ), and Collapsed (one or no OSZ). Dietary intakes were assessed using a brief-type self-administered diet history questionnaire. Atherosclerosis was defined as carotid intima-media thickness ≧1.10 mm by using carotid ultrasonography test. The logistic or linear regression model was used in multivariate analysis to assess relationship between occlusal status and atherosclerosis, and the mediating effect of key nutrients within the relationship. Multivariable analysis showed a significant association between occlusal status and atherosclerosis (odds ratio for Collapsed group to Complete group: 1.87; 95% CI: 1.45-2.41), independent of periodontal status (odds ratio: 2.01, 95%CI: 1.46-2.78). Fish and shellfish, vitamin B6 and n-3PUFAs were significantly related to both of occlusal status and atherosclerosis, and also was indicated a mediating effect on the association between occlusal status and atherosclerosis. This study implied that, within the limitation of the cross-sectional study design, the reduced posterior occlusion was related to the increased prevalence of atherosclerosis via the decline of key dietary intakes among Japanese community-dwelling dentate individuals.
[Mh] Termos MeSH primário: Periodontite Agressiva/epidemiologia
Aterosclerose/epidemiologia
Oclusão Dentária
Dieta
[Mh] Termos MeSH secundário: Idoso
Artérias Carótidas/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182563


  7 / 1756 MEDLINE  
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[PMID]:28682159
[Au] Autor:Sudo T; Okada Y; Ozaki K; Urayama K; Kanai M; Kobayashi H; Gokyu M; Izumi Y; Tanaka T
[Ad] Endereço:1 Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
[Ti] Título:Association of NOD2 Mutations with Aggressive Periodontitis.
[So] Source:J Dent Res;96(10):1100-1105, 2017 Sep.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aggressive periodontitis (AgP) is characterized by rapid alveolar bone destruction and tooth loss early in life, and its etiology remains unclear. To explore the genetic risk factors of AgP, we performed genome-wide single-nucleotide polymorphism genotyping for identity-by-descent mapping and identified 32 distinct candidate loci, followed by whole exome sequencing with 2 pedigrees of AgP consisting of 3 cases and 1 control in 1 family and 2 sibling cases in the other. After variant filtering procedures and validation by targeted Sanger sequencing, we identified 2 missense mutations at 16q12 in NOD2 (p.Ala110Thr and p.Arg311Trp), which encodes nucleotide-binding oligomerization domain protein 2. We further examined 94 genetically unrelated AgP patients by targeted sequencing of NOD2 and found that 2 patients among them also carried the p.Arg311Trp variant. Furthermore, we found 3 additional missense mutations in this gene (p.His370Tyr, p.Arg459Cys, and p.Ala868Thr). These mutations either had not been previously observed or are extremely rare (frequency <0.001) in Asian populations. NOD2 plays a crucial role in innate immunity as an intracellular receptor initiating nuclear factor κB-dependent and mitogen-activated protein kinase-dependent gene transcription. These results demonstrated NOD2 as a novel gene involved in AgP.
[Mh] Termos MeSH primário: Periodontite Agressiva/genética
Mutação de Sentido Incorreto
Proteína Adaptadora de Sinalização NOD2/genética
[Mh] Termos MeSH secundário: Adulto
Exoma
Feminino
Predisposição Genética para Doença
Estudo de Associação Genômica Ampla
Genótipo
Seres Humanos
Japão
Masculino
Linhagem
Fenótipo
Polimorfismo de Nucleotídeo Único
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NOD2 protein, human); 0 (Nod2 Signaling Adaptor Protein)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517715432


  8 / 1756 MEDLINE  
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[PMID]:28662328
[Au] Autor:Toker H; Görgün EP; Korkmaz EM
[Ad] Endereço:Department of Periodontology, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey.
[Ti] Título:Analysis of IL-6, IL-10 and NF-κB Gene Polymorphisms in Aggressive and Chronic Periodontitis.
[So] Source:Cent Eur J Public Health;25(2):157-162, 2017 Jun.
[Is] ISSN:1210-7778
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Pro-inflammatory cytokines, interleukin-6 (IL-6), demonstrated to be suppressed by interleukin-10 (IL-10) are known to be regulated by the transcription factor nuclear factor-κB(NF-κB). The aim of this study was to ascertain the association between genetic polymorphism of these genes (IL-6(-174), IL-10(-597) and NF-κB1-94ins/del)) and chronic/aggressive periodontitis. METHODS: Forty-five patients with chronic periodontitis (CP), 58 patients with aggressive periodontitis (AP) and 38 periodontally healthy subjects were included in this study. Genomic DNA was isolated from whole blood samples. The NF-κB, IL-6, and IL-10 polymorphisms were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: Among subjects for the ins/ins genotypes of NF-κB1 gene, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis group than in healthy controls (p=0.023). A statistically significant difference in genotyping frequencies between AP group and healthy controls was observed for the IL-6 gene. The AA genotype of IL-10 was overrepresented in CP and AP groups compared to healthy controls (OR=9.93, 95% CI: 2.11-46.7, OR=5.7, 95% CI: 1.22-26.89, respectively). CONCLUSIONS: Within the limits of this study, it can be concluded that the IL-10 (-597) AA genotype is associated with susceptibility to chronic/aggressive periodontitis and IL-6 (-174) GG genotypes and G allele seems to be associated with aggressive periodontitis. Clinical relevance: The results of the current study indicate that IL-6 and IL-10 genotypes seem to be associated with aggressive periodontitis. Also, the AA genotypes of IL-10 presented a higher frequency in chronic periodontitis subjects with carrying NF-κB1 ins/ins genotypes.
[Mh] Termos MeSH primário: Periodontite Agressiva/genética
Periodontite Crônica/genética
Interleucina-10/genética
Interleucina-6/genética
NF-kappa B/genética
Polimorfismo Genético
[Mh] Termos MeSH secundário: Adulto
Alelos
Estudos de Casos e Controles
Feminino
Genótipo
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Polimorfismo de Fragmento de Restrição
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (IL10 protein, human); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (NF-kappa B); 130068-27-8 (Interleukin-10)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.21101/cejph.a4656


  9 / 1756 MEDLINE  
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[PMID]:28221099
[Au] Autor:Miyauchi S; Kitagaki J; Masumoto R; Imai A; Kobayashi K; Nakaya A; Kawai S; Fujihara C; Asano Y; Yamashita M; Yanagita M; Yamada S; Kitamura M; Murakami S
[Ad] Endereço:1 Department of Periodontology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
[Ti] Título:Sphingomyelin Phosphodiesterase 3 Enhances Cytodifferentiation of Periodontal Ligament Cells.
[So] Source:J Dent Res;96(3):339-346, 2017 Mar.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sphingomyelin phosphodiesterase 3 ( Smpd3), which encodes neutral sphingomyelinase 2 (nSMase2), is a key molecule for skeletal development as well as for the cytodifferentiation of odontoblasts and alveolar bone. However, the effects of nSMase2 on the cytodifferentiation of periodontal ligament (PDL) cells are still unclear. In this study, the authors analyzed the effects of Smpd3 on the cytodifferentiation of human PDL (HPDL) cells. The authors found that Smpd3 increases the mRNA expression of calcification-related genes, such as alkaline phosphatase (ALPase), type I collagen, osteopontin, Osterix (Osx), and runt-related transcription factor (Runx)-2 in HPDL cells. In contrast, GW4869, an inhibitor of nSMase2, clearly decreased the mRNA expression of ALPase, type I collagen, and osteocalcin in HPDL cells, suggesting that Smpd3 enhances HPDL cytodifferentiation. Next, the authors used exome sequencing to evaluate the genetic variants of Smpd3 in a Japanese population with aggressive periodontitis (AgP). Among 44 unrelated subjects, the authors identified a single nucleotide polymorphism (SNP), rs145616324, in Smpd3 as a putative genetic variant for AgP among Japanese people. Moreover, Smpd3 harboring this SNP did not increase the sphingomyelinase activity or mRNA expression of ALPase, type I collagen, osteopontin, Osx, or Runx2, suggesting that this SNP inhibits Smpd3 such that it has no effect on the cytodifferentiation of HPDL cells. These data suggest that Smpd3 plays a crucial role in maintaining the homeostasis of PDL tissue.
[Mh] Termos MeSH primário: Periodontite Agressiva/genética
Ligamento Periodontal/citologia
Esfingomielina Fosfodiesterase/fisiologia
[Mh] Termos MeSH secundário: Adulto
Periodontite Agressiva/enzimologia
Fosfatase Alcalina/metabolismo
Calcificação Fisiológica
Diferenciação Celular
Linhagem Celular
Células Cultivadas
Colágeno Tipo I/metabolismo
Feminino
Expressão Gênica
Estudo de Associação Genômica Ampla
Seres Humanos
Immunoblotting
Japão
Masculino
Osteocalcina/metabolismo
Osteopontina/metabolismo
Fenótipo
Polimorfismo de Nucleotídeo Único
Reação em Cadeia da Polimerase em Tempo Real
Esfingomielina Fosfodiesterase/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type I); 0 (SPP1 protein, human); 104982-03-8 (Osteocalcin); 106441-73-0 (Osteopontin); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1177/0022034516677938


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[PMID]:28210625
[Au] Autor:Dohan Ehrenfest DM; Piattelli A; Sammartino G; Wang HL
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, The University of Michigan Health System, Ann Arbor, MI, USA; Department of Periodontics and Oral Medicine, The University of Michigan, School of Dentistry, Ann Arbor, MI, USA; LoB5 Research Unit, School of Dentistry & Research Center for Biominerali
[Ti] Título:New Biomaterials and Regenerative Medicine Strategies in Periodontology, Oral Surgery, Esthetic and Implant Dentistry 2016.
[So] Source:Biomed Res Int;2017:8209507, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Periodontite Agressiva/terapia
Materiais Biocompatíveis/uso terapêutico
Implantes Dentários
Medicina Regenerativa
[Mh] Termos MeSH secundário: Periodontite Agressiva/patologia
Odontologia
Seres Humanos
Procedimentos Cirúrgicos Bucais/métodos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Dental Implants)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.1155/2017/8209507



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