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[PMID]:28257738
[Au] Autor:Dolci GS; Portela LV; Onofre de Souza D; Medeiros Fossati AC
[Ad] Endereço:Department of Oral Biology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
[Ti] Título:Atorvastatin-induced osteoclast inhibition reduces orthodontic relapse.
[So] Source:Am J Orthod Dentofacial Orthop;151(3):528-538, 2017 Mar.
[Is] ISSN:1097-6752
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The statin class of drugs enhances osteogenesis and suppresses bone resorption, which could be a plausible biologic mechanism for mitigation of orthodontic relapse. We aimed to determine whether atorvastatin (ATV) might affect orthodontic relapse and osteoclastogenesis by modulating expression of RANKL and osteoprotegerin (OPG), crucial molecules involved in bone turnover. Furthermore, we analyzed the adverse effects of ATV on femur turnover and endochondral ossification. METHODS: Wistar rats were subjected to orthodontic tooth movement for 21 days, followed by removal of the appliance and ATV or saline solution administration. Up to 7, 14, and 21 days of ATV administration, tooth relapse was measured, and maxilla and femur sections were obtained and prepared for hematoxylin and eosin, TRAP, and immunohistochemical (RANKL and OPG) staining. RESULTS: ATV decreased tooth relapse (P = 0.03) and osteoclast counts (P = 0.04), which were positively correlated (P = 0.006). Statin administration increased periodontal expression of OPG (P = 0.008), but not of RANKL protein. ATV administration also enhanced growth plate cartilage thickness. CONCLUSIONS: Statin-induced OPG overexpression reduces relapse after orthodontic tooth movement, in a phenomenon correlated with decreased osteoclast counts. This phenomenon sheds light on OPG as a molecular target that modulates maxillary bone metabolism and orthodontic relapse.
[Mh] Termos MeSH primário: Atorvastatina Cálcica/farmacologia
Osteoclastos/efeitos dos fármacos
Mobilidade Dentária
[Mh] Termos MeSH secundário: Animais
Remodelação Óssea/fisiologia
Fêmur/fisiologia
Imuno-Histoquímica
Masculino
Maxila
Osteoprotegerina/metabolismo
Ligante RANK/metabolismo
Ratos
Ratos Wistar
Recidiva
Técnicas de Movimentação Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Osteoprotegerin); 0 (RANK Ligand); 48A5M73Z4Q (Atorvastatin Calcium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


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[PMID]:28081119
[Au] Autor:Shu R; Bai D; Sheu T; He Y; Yang X; Xue C; He Y; Zhao M; Han X
[Ad] Endereço:Department of Orthodontics, State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
[Ti] Título:Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement.
[So] Source:PLoS One;12(1):e0167312, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tooth movement is a biological process of bone remodeling induced by mechanical force. Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling. However, little is known regarding the role of sclerostin in tooth movement. In this study, models of experimental tooth movement were established in rats and mice. Sclerostin expression was investigated with immunohistochemistry staining, and osteoclastic activity was analyzed with tartrate-resistant acid phosphatase (TRAP) staining. MLO-Y4 osteocyte-like cells underwent uniaxial compression and tension stress or were cultured in hypoxia conditions. Expression of sclerostin was assessed by RT-qPCR and ELISA. MLO-Y4 cells were cultured with recombinant human sclerostin (rhSCL) interference and then co-cultured with RAW264.7 osteoclast precursor cells. Expressions of RANKL and OPG were analyzed by RT-qPCR, and osteoclastic activity was assessed by TRAP staining. During tooth movement, sclerostin was expressed differently in compression and tension sites. In SOST knock-out mice, there were significantly fewer TRAP-positive cells than in WT mice during tooth movement in compression sites. In-vitro studies showed that the expression of sclerostin in MLO-Y4 osteocyte-like cells was not different under a uniaxial compression and tension force, whereas hypoxia conditions significantly increased sclerostin expression in MLO-Y4 cells. rhSCL interference increased the expression of RANKL and the RANKL/OPG ratio in MLO-Y4 cells and the osteoclastic induction ability of MLO-Y4 cells in experimental osteocyte-osteoclast co-culture. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.
[Mh] Termos MeSH primário: Proteínas Morfogenéticas Ósseas/metabolismo
Remodelação Óssea/fisiologia
Glicoproteínas/metabolismo
Osteócitos/metabolismo
Mobilidade Dentária/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas Morfogenéticas Ósseas/farmacologia
Remodelação Óssea/efeitos dos fármacos
Hipóxia Celular
Linhagem Celular
Marcadores Genéticos
Glicoproteínas/farmacologia
Seres Humanos
Masculino
Camundongos
Osteoprotegerina/metabolismo
Ligante RANK/metabolismo
Células RAW 264.7
Ratos
Ratos Sprague-Dawley
Fosfatase Ácida Resistente a Tartarato/metabolismo
Técnicas de Movimentação Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Morphogenetic Proteins); 0 (Genetic Markers); 0 (Glycoproteins); 0 (Osteoprotegerin); 0 (RANK Ligand); 0 (SOST protein, human); 0 (Sost protein, mouse); 0 (Sost protein, rat); 0 (Tnfrsf11b protein, mouse); 0 (Tnfrsf11b protein, rat); 0 (Tnfsf11 protein, mouse); EC 3.1.3.2 (ACP5 protein, human); EC 3.1.3.2 (Acp5 protein, mouse); EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0167312


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[PMID]:27981392
[Au] Autor:Sun J; Du J; Feng W; Lu B; Liu H; Guo J; Amizuka N; Li M
[Ad] Endereço:Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Bone Metabolism, School of Stomatology, Shandong University, Wenhua West Road 44-1, Jinan, 250012, China.
[Ti] Título:Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats.
[So] Source:J Mol Histol;48(2):73-81, 2017 Apr.
[Is] ISSN:1567-2387
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This study evaluated the effects of metformin on orthodontic tooth movement in a rat model of type 2 diabetes mellitus. Rats were fed a high-fat diet for 4 weeks to induce fat accumulation and insulin resistance, and then injected with a low dose of streptozotocin (35 mg/kg) intraperitoneally to induce type 2 diabetes. An orthodontic appliance was placed in normoglycemic, type 2 diabetes, and type 2 diabetes with metformin-administrated rats. After 14 days, type 2 diabetes rats exhibited greater orthodontic tooth movement and had a higher number of tartrate-resistant acid phosphatase-positive osteoclasts, stronger cathepsin K expression, and weaker alkaline phosphatase immunostaining than normoglycemic rats. Metformin administration resulted in normalization of osteoclast numbers, cathepsin K immunostaining, and of tooth movement as well as partly recovery of alkaline phosphatase expression in diabetic rats. Metformin also reduced sclerostin expression and improved the immunolocalization of dentin matrix protein 1 in osteocytes of type 2 diabetes rats. These results suggest that metformin administration reversed the adverse effects of diabetes on orthodontic tooth movement.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/complicações
Mobilidade Dentária/tratamento farmacológico
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Catepsina K
Complicações do Diabetes/tratamento farmacológico
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Tipo 2/complicações
Diabetes Mellitus Tipo 2/tratamento farmacológico
Proteínas da Matriz Extracelular/análise
Hipoglicemiantes
Metformina
Osteoclastos/patologia
Osteócitos/química
Fosfoproteínas/análise
Ratos
Mobilidade Dentária/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dmp1 protein, rat); 0 (Extracellular Matrix Proteins); 0 (Hypoglycemic Agents); 0 (Phosphoproteins); 9100L32L2N (Metformin); EC 3.1.3.1 (Alkaline Phosphatase); EC 3.4.22.38 (Cathepsin K)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.1007/s10735-016-9707-y


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[PMID]:27133183
[Au] Autor:Wang CH; Lin YT; Lin YJ
[Ad] Endereço:Department of Dentistry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
[Ti] Título:A survey of natal and neonatal teeth in newborn infants.
[So] Source:J Formos Med Assoc;116(3):193-196, 2017 Mar.
[Is] ISSN:0929-6646
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/PURPOSE: Since there is no comprehensive research of natal and neonatal teeth in Taiwan, careful investigation of natal or neonatal teeth is worthy of being studied. This retrospective study investigated the prevalence and clinical characteristics of natal or neonatal teeth in a hospital setting, and analyzed the possible relationships between investigated variables of the natal or neonatal teeth. METHODS: All of the 12,019 infants born at an assigned hospital between January 1, 2008 and December 31, 2014 were investigated for natal or neonatal teeth. The identified individuals were reviewed for systemic diseases. Dental examinations included the location, clinical appearance, and degree of mobility. A positive family history of natal or neonatal teeth and mother's physical condition before delivery were also investigated. The collected data were analyzed using Fisher's exact test. RESULTS: Thirty infants were identified with a total of 43 natal or neonatal teeth (females, 19; males, 11). Most of the teeth were in the mandibular primary incisor position (97.6%). A radiographic examination confirmed that not all of the natal or neonatal teeth were supernumerary. No significant differences were observed between males and females in tooth morphology, positive family history, and treatment methods (p > 0.05) or between normal and conical shapes in positive family history, premature infant, mother's physical condition before delivery, and treatment methods (p > 0.05). CONCLUSION: Most of the natal or neonatal teeth were in the mandibular primary incisor position and not all of them were supernumerary. No gender differences were found in tooth morphology, positive family history, and treatment methods. The tooth morphology was not significantly related to a positive family history, premature delivery, or the mother's physical condition before delivery.
[Mh] Termos MeSH primário: Incisivo
Mandíbula/diagnóstico por imagem
Dentes Natais
Dente Supranumerário/epidemiologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Lactente
Recém-Nascido
Masculino
Prevalência
Radiografia Dentária
Estudos Retrospectivos
Taiwan
Erupção Dentária
Extração Dentária
Mobilidade Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE


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[PMID]:27876716
[Au] Autor:Zorina OA; Aimadinova NK; Basova AA; Rebrikov DV
[Ad] Endereço:Sechenov First Moscow State Medical University, Moscow, Russia; Central Research Institute of Dentistry and Maxillofacial Surgery of Ministry of Health of Russian Federation, Moscow, Russia.
[Ti] Título:[The relationship of molecular genetic markers with clinical signs and risk factors of periodontitis].
[Ti] Título:Vzaimosvyaz' molekulyarno-geneticheskikh markerov s klinicheskimi priznakami i faktorami riska razvitiya parodontita..
[So] Source:Stomatologiia (Mosk);95(5):12-18, 2016.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The study revealed positive correlation between bleeding on probing and teeth loss risk with periodontal hypercolonization by Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. Pathological tooth mobility was associated with hypercolonization by P. intermedia and Tannerella forsythensis. Expression of IL8, TNF-α, MMP8 and MMP9 genes was also assessed in patient groups divided according to the depth of periodontal pockets and-the severity of chronic periodontitis revealing IL8 as positive diagnostic marker.
[Mh] Termos MeSH primário: Periodontite/diagnóstico
Periodontite/genética
Transcriptoma
[Mh] Termos MeSH secundário: Adulto
Doença Crônica
Feminino
Marcadores Genéticos
Hemorragia/etiologia
Hemorragia/genética
Seres Humanos
Interleucina-8/genética
Masculino
Metaloproteinase 8 da Matriz/genética
Metaloproteinase 9 da Matriz/genética
Meia-Idade
Bolsa Periodontal/etiologia
Bolsa Periodontal/genética
Periodontite/complicações
Periodontite/microbiologia
Porphyromonas gingivalis/isolamento & purificação
Prevotella intermedia/isolamento & purificação
Fatores de Risco
Perda de Dente/etiologia
Perda de Dente/genética
Mobilidade Dentária/etiologia
Mobilidade Dentária/genética
Treponema denticola/isolamento & purificação
Fator de Necrose Tumoral alfa/genética
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers); 0 (Interleukin-8); 0 (Tumor Necrosis Factor-alpha); EC 3.4.24.34 (Matrix Metalloproteinase 8); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.17116/stomat201695512-18


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[PMID]:27876715
[Au] Autor:Morozov KA; Matveev AP; Morozov EK; Kabanov YV
[Ad] Endereço:Moscow State Medical and Dental University named after A.I. Evdokimov, Moscow, Russia.
[Ti] Título:[Diagnostics of tooth supporting structures].
[Ti] Título:Diagnostika sostoyaniya oporno-uderzhivayushchego apparata zubov..
[So] Source:Stomatologiia (Mosk);95(5):8-11, 2016.
[Is] ISSN:0039-1735
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The aim of the study was to assess alveolar bone resorption in patients with periodontal disease and individuals with normal periodontal status and coordinate resorbtion rates with tooth mobility. Tooth mobility was measured in 19 patients with periodontal disease and 17 healthy individuals by two-parametrical periodontometry in two different positions: in equilibrium and after pre-loading. The level of bone resorption was determined by periodontal probe. Previously unknown correlation between tooth mobility and alveolar bone resorption was found out meaning that bone atrophy can be determined by tooth mobility.
[Mh] Termos MeSH primário: Perda do Osso Alveolar/diagnóstico
Doenças Periodontais/complicações
Periodonto/patologia
Mobilidade Dentária/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Perda do Osso Alveolar/etiologia
Perda do Osso Alveolar/patologia
Seres Humanos
Meia-Idade
Doenças Periodontais/patologia
Mobilidade Dentária/etiologia
Mobilidade Dentária/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.17116/stomat20169558-11


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[PMID]:27761588
[Au] Autor:Wolf M; Schulte U; Küpper K; Bourauel C; Keilig L; Papageorgiou SN; Dirk C; Kirschneck C; Daratsianos N; Jäger A
[Ad] Endereço:Department of Orthodontics, University of Bonn, Welschnonnenstrasse 17, 53111, Bonn, Germany. michael.wolf@uni-bonn.de.
[Ti] Título:Post-treatment changes in permanent retention.
[Ti] Título:Post-therapeutische Veränderungen unter permanenter Retention..
[So] Source:J Orofac Orthop;77(6):446-453, 2016 Nov.
[Is] ISSN:1615-6714
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: While permanent retention is today the method of choice to stabilize orthodontic treatment outcomes, recent studies have increasingly reported posttreatment changes in tooth position during permanent retention. We conducted this study to analyze changes in the anterior mandible, whether the changes follow an underlying movement pattern, and, aiming for a preventive strategy, whether any risk factors could be identified comparing findings with the pretreatment situations. METHODS: We included 30 patients who had worn fixed Twistflex retainers (UK 3-3) extending from canine to canine in the mandible. Casts reflecting the intraoral situations before orthodontic treatment (T0), directly after completion of active therapy (T1), and 6 months later (T2) were scanned and superimposed using Imageware Surfacer software. Posttreatment changes (T2-T1) of tooth position within the retainer block were analyzed on 3D virtual models and were compared to pretreatment (T0) and treatment-related (T1-T0) findings to identify potential risk factors. RESULTS: Almost all analyzed patients revealed three-dimensional changes in tooth position within the retainer block. Comparing these movements, we repeatedly found rotated retainer blocks in labio-oral direction, while the center of rotation was located at the first incisors. This pattern was associated with intercanine expansion and excessive overjet correction during orthodontic treatment. The canines underwent the most pronounced (rotational and translational) movements. CONCLUSIONS: In general permanent lingual retainers are safe but in special clinical cases retainers can induce undesired tooth movement. Risk factors seem to be intercanine expansion and excessive overjet correction during orthodontic treatment. In specific cases an additional retention device might be needed.
[Mh] Termos MeSH primário: Falha de Restauração Dentária
Má Oclusão/etiologia
Má Oclusão/prevenção & controle
Contenções Ortodônticas/efeitos adversos
Mobilidade Dentária/patologia
Mobilidade Dentária/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Cefalometria
Feminino
Seres Humanos
Masculino
Má Oclusão/patologia
Mandíbula/patologia
Reprodutibilidade dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Mobilidade Dentária/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161021
[St] Status:MEDLINE


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Camargo, Elisa Souza
PubMed Central Texto completo
Texto completo
[PMID]:27487121
[Au] Autor:da Silva Kagy V; Trevisan Bittencourt Muniz L; Michels AC; Luiz ST; Reis Azevedo Alanis L; Brancher JA; Grégio AM; Ignácio SA; Camargo ES; Machado MÂ; Johann AC
[Ad] Endereço:Department of School of Health and Biosciences of Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brazil.
[Ti] Título:Effect of the Chronic Use of Lithium Carbonate on Induced Tooth Movement in Wistar Rats.
[So] Source:PLoS One;11(8):e0160400, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One hundred and ninety-two rats were divided into 3 groups. In the L group, the animals received daily 60mg/kg of LC, they were not subjected to orthodontic movement, and they were euthanized after 33, 37, 44 or 51 days. In the LM group, the LC was administered for 30 days and during the subsequent 3, 7, 14 and 21 days, corresponding to the period of induced tooth movement, and they received a spring that produced a 30cN force. In the SM group, saline solution was applied. Measurements were made of tooth displacement, the numbers of osteoclasts and serum lithium phosphate (PO4), alkaline phosphatase (ALP) and creatinine levels. The tooth displacement was lower in the LM group compared to the SM group at 44 days. A tendency toward reduction in the number of osteoclasts was observed in the LM group compared to the SM group at 44 days. The average lithium were higher in the L and LM groups compared to the SM group. The opposite was observed for the PO4 group. A higher value for the ALP was found in the L group. The average creatinine level was lower in the LM group. LC inhibited tooth movement for 14 days, possibly due to the reduction in the number of osteoclasts.
[Mh] Termos MeSH primário: Antimaníacos/efeitos adversos
Carbonato de Lítio/efeitos adversos
Técnicas de Movimentação Dentária
Dente/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimaníacos/administração & dosagem
Remodelação Óssea/efeitos dos fármacos
Esquema de Medicação
Carbonato de Lítio/administração & dosagem
Masculino
Aparelhos Ortodônticos
Ratos
Ratos Wistar
Fatores de Tempo
Dente/fisiologia
Mobilidade Dentária/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimanic Agents); 2BMD2GNA4V (Lithium Carbonate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160400


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[PMID]:27384715
[Au] Autor:AlSubaie M; Talic N; Khawatmi S; Alobeid A; Bourauel C; El-Bialy T
[Ad] Endereço:Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
[Ti] Título:Study of force loss due to friction comparing two ceramic brackets during sliding tooth movement.
[Ti] Título:Vergleichende Studie zum reibungsbedingten Kraftverlust während der bogengeführten Zahnbewegung durch zwei Keramikbrackets..
[So] Source:J Orofac Orthop;77(5):334-40, 2016 Sep.
[Is] ISSN:1615-6714
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the percentage of force loss generated during canine sliding movements in newly introduced ceramic brackets with metal brackets. MATERIALS AND METHODS: Two types of ceramic brackets, namely polycrystalline alumina (PCA) ceramic brackets (Clarity Advanced) and monocrystalline alumina (MCA) ceramic brackets (Inspire Ice) were compared with stainless steel (SS) brackets (Victory Series). All bracket groups (n = 5 each) were for the maxillary canines and had a 0.018-inch slot size. The brackets were mounted on an Orthodontic Measurement and Simulation System (OMSS) to simulate the canine retraction movement into the first premolar extraction space. Using elastic ligatures, 0.016 × 0.022″ (0.40 × 0.56 mm) stainless steel archwires were ligated onto the brackets. Retraction force was applied via a nickel-titanium coil spring with a nearly constant force of approximately 1 N. The OMSS measured the percentage of force loss over the retraction path by referring to the difference between the applied retraction force and actual force acting on each bracket. Between group comparisons were done with one-way analysis of variance. RESULTS: The metal brackets revealed the lowest percentage of force loss due to friction, followed by the PCA and MCA ceramic bracket groups (67 ± 4, 68 ± 7, and 76 ± 3 %, respectively). There was no significant difference between SS and PCA brackets (p = 0.97), but we did observe significant differences between metal and MCA brackets (p = 0.03) and between PCA and MCA ceramic brackets (p = 0.04). CONCLUSION: PCA ceramic brackets, whose slot surface is covered with an yttria-stabilized zirconia-based coating exhibited frictional properties similar to those of metal brackets. Frictional resistance resulted in an over 60 % loss of the applied force due to the use of elastic ligatures.
[Mh] Termos MeSH primário: Cerâmica/química
Dente Canino/fisiologia
Análise do Estresse Dentário/métodos
Braquetes Ortodônticos
Mobilidade Dentária/fisiopatologia
Técnicas de Movimentação Dentária/métodos
[Mh] Termos MeSH secundário: Materiais Dentários/química
Planejamento de Prótese Dentária
Análise de Falha de Equipamento
Fricção
Seres Humanos
Técnicas In Vitro
Movimento (Física)
Estresse Mecânico
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Materials)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1007/s00056-016-0038-0


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[PMID]:27357508
[Au] Autor:Sun C; Chen L; Shi X; Cao Z; Hu B; Yu W; Ren M; Hu R; Deng H
[Ad] Endereço:Department of Orthodontics, School of Stomatology, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
[Ti] Título:Combined effects of proinflammatory cytokines and intermittent cyclic mechanical strain in inhibiting osteogenicity in human periodontal ligament cells.
[So] Source:Cell Biol Int;40(9):999-1007, 2016 Sep.
[Is] ISSN:1095-8355
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Mechanical strain plays an important role in bone formation and resorption during orthodontic tooth movement. The mechanism has not been fully studied, and the process becomes complex with increased amounts of periodontal patients seeking orthodontic care. Our aims were to elucidate the combined effects of proinflammatory cytokines and intermittent cyclic strain (ICS) on the osteogenic capacity of human periodontal ligament cells. Cultured human periodontal ligament cells were exposed to proinflammatory cytokines (interleukin-1ß 5 ng/mL and tumor necrosis factor-α 10 ng/mL) for 1 and 5 days, and ICS (0.5 Hz, 12% elongation) was applied for 4 h per day. The autocrine of inflammatory cytokines was measured by enzyme-linked immunosorbent assay. The expression of osteoblast markers runt-related transcription factor 2 and rabbit collagen type I was determined using real-time polymerase chain reaction and Western blot. The osteogenic capacity was also detected by alkaline phosphatase (ALP) staining, ALP activity, and alizarin red staining. We demonstrated that ICS impaired the osteogenic capacity of human periodontal ligament cells when incubated with proinflammatory cytokines, as evidenced by the low expression of ALP staining, low ALP activity, reduced alizarin red staining, and reduced osteoblast markers. These data, for the first time, suggest that ICS has a negative effect on the inductive inhibition of osteogenicity in human PDL cells mediated by proinflammatory cytokines.
[Mh] Termos MeSH primário: Citocinas/metabolismo
Osteogênese/fisiologia
Ligamento Periodontal/metabolismo
Mobilidade Dentária/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Diferenciação Celular/fisiologia
Células Cultivadas
Citocinas/imunologia
Feminino
Seres Humanos
Inflamação/metabolismo
Masculino
Osteoblastos/citologia
Osteoblastos/metabolismo
Ligamento Periodontal/citologia
Ligamento Periodontal/imunologia
Periodontite/metabolismo
Periodontite/patologia
Estresse Mecânico
Mobilidade Dentária/imunologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1002/cbin.10641



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