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Pesquisa : C07.465.815.355 [Categoria DeCS]
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[PMID]:29309109
[Au] Autor:Bozic K; Glisic B; Radic-Tasic O; Knezevic B
[Ti] Título:Case report of Mikulicz's disease: A modern concept of an old entity.
[So] Source:Vojnosanit Pregl;73(4):393-6, 2016 Apr.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Introduction: Modern knowlegde defines Mikulicz´s disease as a part of immunoglobulin G4-related disease. The main feature is the presence of lymphoplasmacytic infiltrates, immunoglobulin G4 plasma cells positivity, distinctive storiform fibrosis and moderate eosinophilia. Case Report: A 59-years old male presented with a mild keratoconjuctivitis sicca and enlarged lacrimal and salivary glands during the last two years. Althought clinical presentation of the patient was typical, earlier testing did not pinpoint Mikulicz ´s disease. By typical clinical presentation, elevated serum immunoglobulin G4 level and histopathological finding of lacrimal glands tissue we diagnosed Mikulicz´s disease successfully treated with corticosteroid therapy. Conclusion: We reported the first case of IgG4-related Mikulicz´s disease in Serbia. Our report highlights IgG4-related Mikulicz` s disease as an important differential diagnosis with Sjögren`s syndrome and lymphoproliferative disease in rheumatological practice.
[Mh] Termos MeSH primário: Doença de Mikulicz/diagnóstico
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina G/metabolismo
Imuno-Histoquímica
Aparelho Lacrimal/imunologia
Transtornos Linfoproliferativos/diagnóstico
Masculino
Meia-Idade
Doença de Mikulicz/imunologia
Plasmócitos/imunologia
Sérvia
Síndrome de Sjogren/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.2298/VSP150118120B


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[PMID]:28042654
[Au] Autor:Bhagwat NM; Tayde PS; Dalwadi PP; Sorabjee J; Varthakavi PK
[Ad] Endereço:Department of Endocrinology, B.Y.L Nair Charitable Hospital & Topiwala National Medical College, Mumbai-400008, India. bhagwatnik@yahoo.co.in.
[Ti] Título:Mikulicz's Disease with hypophysitis - a new IgG4-mediated disorder.
[So] Source:Endokrynol Pol;67(6):622-626, 2016.
[Is] ISSN:2299-8306
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: We present a case of Mikulicz's Disease with hypophysitis. This is a rare clinical association as part of the group of IgG4- related diseases, a group of disorders which can have multiorgan involvement. METHODS: A 55-year-old male patient was diagnosed with Mikulicz's disease. He was treated with oral steroids for six months with complete resolution. After two years the patient presented with fatigue, generalised weakness, and weight loss of 11 kg over six months. On evaluation he was found to have panhypopituitarism. MRI pituitary revealed homogeneously enlarged, well enhancing pituitary with thickening of the stalk. Serum IgG4 levels were significantly elevated. The patient was treated with methyl prednisolone pulse therapy followed by oral steroids for three months. He developed diabetes insipidus after starting steroid therapy. There was a significant resolution in the enlargement of the pituitary and stalk thickening at three months. RESULTS: The clinical, biochemical, and radiological findings of hypophysitis associated with Mikulicz's disease are presented with a brief review of literature. CONCLUSIONS: IgG4-related diseases are rare and have recently been recognised as a cause of hypophysitis. They can have multiorgan involvement. A high index of suspicion is required for clinching this rare diagnosis, which can be confirmed by measurement of serum levels of IgG4. Steroid therapy can reverse the inflammatory changes in IgG4 hypophysitis. (Endokrynol Pol 2016; 67 (6): 622-626).
[Mh] Termos MeSH primário: Hipofisite Autoimune/complicações
Hipopituitarismo/etiologia
Doença de Mikulicz/complicações
Hipófise/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anti-Inflamatórios/uso terapêutico
Hipofisite Autoimune/diagnóstico
Hipofisite Autoimune/tratamento farmacológico
Seres Humanos
Hipopituitarismo/diagnóstico
Hipopituitarismo/tratamento farmacológico
Masculino
Metilprednisolona/uso terapêutico
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); X4W7ZR7023 (Methylprednisolone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE
[do] DOI:10.5603/EP.2016.0071


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[PMID]:27987516
[Au] Autor:Liu AC; Chen Y; Jia JS; Gao SY; Liu YY
[Ad] Endereço:Department of Kidney, Peking University People's Hospital, Beijing 100044, China.
[Ti] Título:[Non-Hodgkin's lymphoma mimicking Mikulicz disease: a case report].
[So] Source:Beijing Da Xue Xue Bao Yi Xue Ban;48(6):1074-1076, 2016 12 18.
[Is] ISSN:1671-167X
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:IgG4-related disease is a systemic disorder involving a spectrum of multiple indications, and various histopathological features are shared among different IgG4-related disease subtypes, which challenge diagnosis, although certain syndromes have organ-specific involvement. Among them, Mikulicz's disease affecting the salivary and lacrimal glands, distinguished by often elevated levels of serum IgG4, infiltration of IgG4 plasma cells into target tissues, and diffuse swelling, mass formation, or fibrosis of affected organs. However, there are several diseases, which could manifest as salivary gland swelling, mimicking Mikulicz's disease, such as Sjogren's syndrome, mumps virus infection, obstruction of parotid duct, non-Hodgkin's lymphoma (NHL), and so on. So differential diagnosis is important and essential as to the salivary gland swelling. In this paper, we analyzed a case of a 59-year-old male with symmetric salivary gland swelling. Mikulicz's disease was misdiagnosed at the beginning without biopsy. Prednisone treatment ever seemed to be effective and antibiotics had no effect. Besides salivary involvement, the patient also manifested as testicle swelling and severe pancytopenia with the development of the disease, which rarely appeared in Mikulicz's disease. Physical examination showed skin, sclera yellow dye, swollen submandibular, sublingual and lacrimal gland and splenomegaly. As a result, biopsy of right submandibular gland was made, and mucosa-associated lymphoid tissue lymphoma was confirmed by morphology and immunohistochemistry. Bone marrow biopsy also confirmed that lymphoma cells were found in the bone marrow. Finally, the diagnosis of mucosa-associated lymphoid tissue lymphoma (Phase IVE, Group A) was made on the patient, who was transferred to the hematology department for the treatment. NHL, especially, primary extranodal lymphoma usually involves the salivary gland, and painless swelling of the salivary gland is a common manifestation, similar with Mikulicz's disease. So although salivary gland swelling is often associated with autoimmune diseases such as Sjogren's syndrome and IgG4-related disease, the awareness and suspicion of a possibility of NHL are essential for rheumatologists. Biopsy is a necessary examination to decrease or avoid misdiagnosis.
[Mh] Termos MeSH primário: Linfoma de Zona Marginal Tipo Células B/diagnóstico
[Mh] Termos MeSH secundário: Doenças Autoimunes/diagnóstico
Biópsia
Exame de Medula Óssea
Diagnóstico Diferencial
Edema/etiologia
Fibrose
Seres Humanos
Imunoglobulina G/imunologia
Imuno-Histoquímica
Aparelho Lacrimal/imunologia
Aparelho Lacrimal/patologia
Linfoma de Zona Marginal Tipo Células B/patologia
Linfoma de Zona Marginal Tipo Células B/fisiopatologia
Masculino
Meia-Idade
Doença de Mikulicz/diagnóstico
Pancitopenia/etiologia
Glândulas Salivares/imunologia
Glândulas Salivares/patologia
Esplenomegalia/etiologia
Glândula Submandibular
Testículo/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE


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[PMID]:27795505
[Au] Autor:Nanke Y; Kobashigawa T; Yago T; Kawamoto M; Yamanaka H; Kotake S
[Ad] Endereço:Institute of Rheumatology, Tokyo Women's Medical University.
[Ti] Título:Detection of IFN-γ+IL-17+ cells in salivary glands of patients with Sjögren's syndrome and Mikulicz's disease: Potential role of Th17•Th1 in the pathogenesis of autoimmune diseases.
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;39(5):473-477, 2016.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:  Objective: Th17 cells, which mainly produce interleukin (IL)-17, have been suggested to play a critical role in the pathogenesis of autoimmune diseases. The plasticity of Th17 cells, in which these cells shift to a Th1 phenotype in the presence of IL-12, has recently been reported. However, the role of IL-17 in Sjögren's syndrome (SS) and Mikulicz's disease (MD) currently remains unknown. PATIENTS AND METHODS: The submandibular salivary gland and lymph node of a MD patient and the salivary glands of 15 SS patients were collected. IFN-γ+ cells, IL-17+ cells, and IFN-γ+IL-17+ cells were detected by immunohistochemical staining. RESULTS: IFN-γ+ cells, IL-17+ cells, and IFN-γ+IL-17+ cells were detected in the submandibular salivary gland and lymph node of the MD patient and salivary glands of the 15 SS patients. DISCUSSION: IFN-γ+IL-17+cells in the salivary glands of patients were speculated to be Th1/Th17 cells in the present study. Th1/Th17 cells are known to be derived from Th17 cells and differentiate into Th1 cells, and IL-17-derived Th1 cells have been suggested to induce the deterioration of juvenile idiopathic arthritis (JIA). Thus, Th1/Th17 cells may play an important role in the pathogenesis of SS and MD. CONCLUSION: IFN-γ+, IFN-γ+IL-17+, and IL-17+ cells were detected in the submandibular salivary gland and lymph node of a MD patient and the salivary glands of 15 SS patients.
[Mh] Termos MeSH primário: Plasticidade Celular/imunologia
Doença de Mikulicz/imunologia
Glândulas Salivares/citologia
Glândulas Salivares/imunologia
Síndrome de Sjogren/imunologia
Células Th1/imunologia
Células Th17/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Artrite Juvenil/imunologia
Artrite Juvenil/patologia
Diferenciação Celular
Feminino
Seres Humanos
Imuno-Histoquímica
Interferon gama/biossíntese
Interleucina-12/imunologia
Interleucina-17/biossíntese
Linfonodos/citologia
Linfonodos/imunologia
Meia-Idade
Doença de Mikulicz/patologia
Síndrome de Sjogren/patologia
Células Th17/citologia
Células Th17/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-17); 187348-17-0 (Interleukin-12); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE


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[PMID]:27631251
[Au] Autor:Chuang TL; Hsu BB; Chi CL; Wang YF
[Ad] Endereço:aDepartment of Nuclear Medicine bDepartment of Allergy, Immunology and Rheumatology cDepartment of Pathology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi dSchool of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.
[Ti] Título:Gallium SPECT/CT in evaluation of IgG4-related disease: A case report and literature review.
[So] Source:Medicine (Baltimore);95(37):e4865, 2016 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The clinical picture of IgG4-related sclerosing disease (IgG4-RSD) may mimic lymphoma, and should be in the differential diagnosis of patients with this clinical picture. CASE SUMMARY: A 32-year-old female had recurrent swelling of both eyelids for more than 15 years. Examination revealed elastic, firm, swollen lacrimal glands about 2-3 cm in diameter that was not painful. Head and orbits magnetic resonance imaging (MRI) showed mass lesions over the bilateral lacrimal glands, submandibular glands, and left foramen of ovale. The differential diagnosis included lymphoid tissue, inflammatory masses, and lymphoma. Gallium single-photon emission computed tomography/computed tomography (SPECT/CT) showed uptake in the bilateral lacrimal glands, right parotid and bilateral submandibular glands, bilateral perirenal region, mediastinal, prevertebral, paraaortic, lumbar, bilateral pelvic (including internal iliac chain) lymph nodes, anterior aspect of right 3rd rib, and lateral aspect of left 6th rib. CT showed multiple enlarged lymph nodes in the mediastinum, right pulmonary hilum, prevertebral space of the thoracolumbar spine, retroperitoneal paraaortic area, bilateral parailiac areas, and bilateral perirenal spaces. Antinuclear and anti-SSA/SSB antibodies were negative, and the serum IgG4 level was 740 mg/dL (normal, 8-140 mg/dL). Right parotid gland biopsy showed abundant IgG4-positive plasma cells. Mikulicz disease (IgG4-related sclerosing disease) was diagnosed and she received glucocorticoid treatment. Follow-up CT and MRI showed with resolved eyelid swelling and perirenal mass lesions. Follow-up gallium scan was normal. CONCLUSION: Gallium SPECT/CT can be a useful tool for initial and follow-up evaluation of IgG4-RSD.
[Mh] Termos MeSH primário: Doença de Mikulicz/diagnóstico por imagem
Tomografia Computadorizada com Tomografia Computadorizada de Emissão de Fóton Único
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Imunoglobulina G/sangue
Doença de Mikulicz/sangue
Doença de Mikulicz/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160916
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004865


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[PMID]:27311268
[Au] Autor:Goto H; Takahira M; Azumi A; Japanese Study Group for IgG4-Related Ophthalmic Disease
[Ti] Título:[Diagnostic Criteria for IgG4-related Ophthalmic Disease].
[So] Source:Nippon Ganka Gakkai Zasshi;120(5):365-8, 2016 May.
[Is] ISSN:0029-0203
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Mh] Termos MeSH primário: Oftalmopatias/diagnóstico
Imunoglobulina G
[Mh] Termos MeSH secundário: Seres Humanos
Imunoglobulina G/análise
Doença de Mikulicz/diagnóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160617
[Lr] Data última revisão:
160617
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE


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[PMID]:26849056
[Au] Autor:Li J; Ge X; Wang X; Liu X; Ma J
[Ad] Endereço:Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.
[Ti] Título:Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland.
[So] Source:PLoS One;11(2):e0148290, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: We aimed to examine the potential involvement of local complement system gene expression in the pathogenesis of benign lymphoepithelial lesions (BLEL) of the lacrimal gland. METHODS: We collected data from 9 consecutive pathologically confirmed patients with BLEL of the lacrimal gland and 9 cases with orbital cavernous hemangioma as a control group, and adopted whole genome microarray to screen complement system-related differential genes, followed by RT-PCR verification and in-depth enrichment analysis (Gene Ontology analysis) of the gene sets. RESULTS: The expression of 14 complement system-related genes in the pathologic tissue, including C2, C3, ITGB2, CR2, C1QB, CR1, ITGAX, CFP, C1QA, C4B|C4A, FANCA, C1QC, C3AR1 and CFHR4, were significantly upregulated while 7 other complement system-related genes, C5, CFI, CFHR1|CFH, CFH, CD55, CR1L and CFD were significantly downregulated in the lacrimal glands of BLEL patients. The microarray results were consistent with RT-PCR analysis results. Immunohistochemistry analysis of C3c and C1q complement component proteins in the resected tissue were positive in BLEL patients, while the control group had negative expression of these proteins. Gene ontology (GO) analysis revealed that activation of the genes of complement system-mediated signaling pathways were the most enriched differential gene group in BLEL patients. CONCLUSIONS: Local expression of complement components is prominently abnormal in BLEL, and may well play a role in its pathogenesis.
[Mh] Termos MeSH primário: Proteínas do Sistema Complemento/genética
Regulação da Expressão Gênica
Aparelho Lacrimal/metabolismo
Doença de Mikulicz/etiologia
Doença de Mikulicz/genética
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Aparelho Lacrimal/patologia
Masculino
Meia-Idade
Doença de Mikulicz/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9007-36-7 (Complement System Proteins)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160206
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0148290


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[PMID]:26156745
[Au] Autor:Piao Y; Wang C; Yu W; Mao M; Yue C; Liu H; Zhang L
[Ad] Endereço:Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
[Ti] Título:Concomitant occurrence of Mikulicz's disease and immunoglobulin G4-related chronic rhinosinusitis: a clinicopathological study of 12 cases.
[So] Source:Histopathology;68(4):502-12, 2016 Mar.
[Is] ISSN:1365-2559
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Concomitant occurrence of Mikulicz's disease (MD) and immunoglobulin (Ig)G4-related chronic rhinosinusitis (IgG4-related CRS) is extremely rare. We evaluated the clinicopathological features of MD patients with concomitant IgG4-related CRS (CRS-MD). METHODS AND RESULTS: Twelve CRS-MD patients were evaluated clinically and biopsy samples were taken from the lacrimal/salivary glands (n = 12) and nasal mucosa (n = 7) for assessment of IgG4-positive cells, using immunohistochemical techniques. Similarly, nine MD patients and 10 patients with common CRS were evaluated as controls. CRS-MD patients had higher serum IgG and IgG4 concentrations than MD patients (P < 0.05 for both). Lymphoplasmacytic infiltration, lymphoid follicle formation and sclerosis was prominent in the lacrimal/salivary glands in both groups; however, the magnitude of IgG4-positive plasma cells infiltration in the CRS-MD group was significantly higher compared to the MD group (P = 0.004). Similarly, evaluation of nasal mucosa revealed greater lymphocyte, plasma cell and eosinophil infiltration and lymphoid follicle formation, together with significantly higher IgG4-positive plasma cell infiltration in the CRS-MD group compared to the common CRS group (P = 0.004). CONCLUSIONS: Concomitant MD and IgG4-related CRS were characterized by a combination of IgG4-positive plasma cells infiltration in the lacrimal/salivary glands and the nasal mucosa and increased serum IgG4.
[Mh] Termos MeSH primário: Doença de Mikulicz/complicações
Rinite/complicações
Sinusite/complicações
[Mh] Termos MeSH secundário: Adulto
Idoso
Doença Crônica
Feminino
Seres Humanos
Imunoglobulina G
Masculino
Meia-Idade
Doença de Mikulicz/imunologia
Doença de Mikulicz/patologia
Estudos Retrospectivos
Rinite/imunologia
Rinite/patologia
Sinusite/imunologia
Sinusite/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150710
[St] Status:MEDLINE
[do] DOI:10.1111/his.12775


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[PMID]:26608265
[Au] Autor:Sarkar A; Pitchumoni CS
[Ti] Título:The protean manifestations of IgG4-RD in gastrointestinal disorders.
[So] Source:Dis Mon;61(12):493-515, 2015 Dec.
[Is] ISSN:1557-8194
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Gastroenteropatias/diagnóstico
Gastroenteropatias/imunologia
Trato Gastrointestinal/imunologia
Imunoglobulina G/imunologia
[Mh] Termos MeSH secundário: Doenças Autoimunes/diagnóstico
Doenças Autoimunes/imunologia
Doenças Biliares/diagnóstico
Doenças Biliares/imunologia
Gastroenteropatias/terapia
Trato Gastrointestinal/patologia
Seres Humanos
Imunoglobulina G/metabolismo
Imunossupressores/uso terapêutico
Hepatopatias/diagnóstico
Hepatopatias/imunologia
Doença de Mikulicz/diagnóstico
Doença de Mikulicz/imunologia
Pancreatite/diagnóstico
Pancreatite/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Immunosuppressive Agents)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151221
[Lr] Data última revisão:
151221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151127
[St] Status:MEDLINE


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[PMID]:26587853
[Au] Autor:Udell J
[Ti] Título:IgG4-Related Disease: Treatment and Insight Into Pathophysiology: Video of the Lecture by John Stone MD, MPH.
[So] Source:J Clin Rheumatol;21(8):426, 2015 Dec.
[Is] ISSN:1536-7355
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Glucocorticoides/uso terapêutico
Imunoglobulina G/imunologia
Rituximab/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Sistema Imunitário/imunologia
Sistema Imunitário/fisiopatologia
Imuno-Histoquímica
Fatores Imunológicos/uso terapêutico
Doença de Mikulicz/diagnóstico
Doença de Mikulicz/tratamento farmacológico
Doença de Mikulicz/imunologia
Doença de Mikulicz/fisiopatologia
Glândula Submandibular/imunologia
Glândula Submandibular/patologia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; LECTURES; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Glucocorticoids); 0 (Immunoglobulin G); 0 (Immunologic Factors); 4F4X42SYQ6 (Rituximab)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151121
[Lr] Data última revisão:
151121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151121
[St] Status:MEDLINE
[do] DOI:10.1097/RHU.0000000000000331



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