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[PMID]:28949251
[Au] Autor:Cung TD; Lai W; Svider PF; Hanba C; Samantray J; Folbe AJ; Shkoukani M; Raza SN
[Ad] Endereço:1 Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA.
[Ti] Título:Sialendoscopy in the Management of Radioiodine Induced Sialadenitis: A Systematic Review.
[So] Source:Ann Otol Rhinol Laryngol;126(11):768-773, 2017 Nov.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Salivary gland dysfunction as a consequence of radioiodide ablation is present in as many as two-thirds of patients, and unfortunately, many of these individuals do not respond to conservative measures. Sialendoscopy as a minimally invasive therapeutic modality may have utility in the treatment of radioiodide induced sialadenitis (RAIS). Our aim was to explore whether sialendoscopy resulted in clinical improvement in patients with RAIS. METHODS: A systematic review of studies on sialendoscopy for RAIS was conducted using MEDLINE database, Embase, and Cochrane Library. The outcomes of interest included the proportion of patients demonstrating clinical improvement after intervention, patient demographics, radiation dose, specific procedural variations, specific salivary gland, failure rate, and recurrence. RESULTS: Eight studies met inclusion criteria. Data reviewed showed an increased predilection of parotid sialadenitis relative to submandibular gland sialadenitis. All but 2 studies employed sialendoscopy only after failure of conservative measures. An overall rate of clinical improvement ranging from 75% to 100% was reported. CONCLUSION: This systematic review encompassing 122 patients represents the largest pooled sample to date of patients undergoing sialendoscopy for RAIS. Sialendoscopy represents an invaluable minimally invasive modality that may obviate the need for more invasive surgery as intervention was associated with a high success rate.
[Mh] Termos MeSH primário: Endoscopia/métodos
Radioisótopos do Iodo/efeitos adversos
Sialadenite/etiologia
Sialadenite/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Neoplasias da Glândula Tireoide/radioterapia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Iodine Radioisotopes)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170927
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417732795


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[PMID]:28669304
[Au] Autor:Achim V; Light TJ; Andersen PE
[Ad] Endereço:1 Oregon Health and Science University, Portland, Oregon, USA.
[Ti] Título:Gland Preservation in Patients Undergoing Sialoendoscopy.
[So] Source:Otolaryngol Head Neck Surg;157(1):53-57, 2017 Jul.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective Sialoendoscopy is a minimally invasive technique for the treatment of obstructive sialadenitis. We aim to describe treatment considerations and report our ultimate rate of gland preservation. Study Design Case series with chart review. Setting Academic tertiary hospital. Subject and Methods A total of 128 consecutive sialoendoscopy cases for obstructive sialadenitis between 2009 and 2015 were evaluated. Procedures included endoscopic stricture dilation, basket-assisted stone retrieval, Holmium laser lithotripsy, and combined endoscopic transoral stone excision. Resolution of symptoms, need for additional procedures, and rate of subsequent adenectomy were investigated. Results Sialoendoscopy was completed in 120 of 128 patients (94%). There were 87 parotid gland cases and 41 submandibular gland cases. Endoscopic stricture dilation was attempted in 97 patients and successful in 99%. A sialolith was identified in 31 cases and removed by basket-assisted stone retrieval (10 cases), Holmium:YAG laser stone fragmentation (10 cases), and combined endoscopic transoral stone extraction (4 cases). In 8 cases overall, sialoendoscopy failed, with immediate adenectomy. At a mean follow-up of 18 months, 39 patients (33%) reported recurrence of symptoms, with 90% in the stricture group. For the entire cohort, gland preservation occurred in 112 of 128 patients (88%). Conclusions Sialoendoscopy is an effective technique, with few patients requiring additional procedures. Newer interventional approaches allow for stone retrieval without adenectomy. Patients in the stricture group were more likely to have recurrent symptoms as compared with the sialolithiasis group but often benefit from additional sialoendoscopic procedures, leading to a high overall rate of long-term gland preservation of 91%.
[Mh] Termos MeSH primário: Endoscopia/métodos
Sialadenite/cirurgia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Litotripsia a Laser
Masculino
Meia-Idade
Procedimentos Cirúrgicos Minimamente Invasivos
Glândula Parótida/cirurgia
Recidiva
Glândula Submandibular/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817695547


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[PMID]:28499805
[Au] Autor:Mandel L; Greene LW
[Ad] Endereço:Director, Salivary Gland Center; Associate Dean and Clinical Professor, Oral and Maxillofacial Surgery, Columbia University College of Dental Medicine, New York-Presbyterian Medical Center (Columbia Campus), New York, NY. Electronic address: LM7@Columbia.edu.
[Ti] Título:Differentiating I Radiation Sialadenitis From Autoimmune (Sjögren Syndrome) Sialadenitis: Case Report.
[So] Source:J Oral Maxillofac Surg;75(11):2379-2382, 2017 Nov.
[Is] ISSN:1531-5053
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Radioactive iodine ( I) is used effectively for the treatment of differentiated thyroid cancers. Because it is actively secreted by the salivary glands, radiation damage to these glands can occur. Obstructive swellings after mealtime salivary stimulation are common occurrences. Dry mouth is not usually seen if low doses of I are used. A subjective complaint of xerostomia in a patient treated with I 75.8 mCi proved to be related to the simultaneous presence of Sjögren syndrome (SS). Serologic, histologic, scintigraphic, and salivary volume findings and the patient's subjective complaints served to establish the pre-existence of SS.
[Mh] Termos MeSH primário: Sialadenite/patologia
Síndrome de Sjogren/patologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Feminino
Seres Humanos
Radioisótopos do Iodo/efeitos adversos
Meia-Idade
Sialadenite/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; D; IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


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[PMID]:28412783
[Au] Autor:Yu GY
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
[Ti] Título:[Paying attention to the protection of the function organ of submandibular gland].
[So] Source:Zhonghua Kou Qiang Yi Xue Za Zhi;52(4):204-205, 2017 Apr 09.
[Is] ISSN:1002-0098
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Submandibular gland is an important human function organ. With the wide application of sialoendoscope and new understanding of IgG4 related sialadenitis, a lot of submandibular glands which were previously considered to be removed are preserved. However, some submandibular glands which might be preserved are still unfortunately sacrificed. Therefore, we advocate the popularization and promotion of new knowledge and techniques and should pay more attention to the protection of the function organ of submandibular gland.
[Mh] Termos MeSH primário: Endoscopia/métodos
Tratamentos com Preservação do Órgão/métodos
Glândula Submandibular/fisiologia
Glândula Submandibular/cirurgia
[Mh] Termos MeSH secundário: Atenção
Seres Humanos
Imunoglobulina G/imunologia
Sialadenite/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunoglobulin G)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170417
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1002-0098.2017.04.002


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[PMID]:28315910
[Au] Autor:Son H; Lee SM; Yoon RG; Lee H; Lee I; Kim S; Chung WY; Lee JW
[Ad] Endereço:Catholic Kwandong University International St. Mary's Hospital, 25, Simgok-ro 100 beon-gil, Seo-gu, Incheon, 404-834, Korea. jwlee223@ish.or.kr.
[Ti] Título:Effect of selenium supplementation for protection of salivary glands from iodine-131 radiation damage in patients with differentiated thyroid cancer.
[So] Source:Hell J Nucl Med;20(1):62-70, 2017 Jan-Apr.
[Is] ISSN:1790-5427
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: In the current study, we examined whether selenium supplementation during iodine-131 ( I) treatment had a radio-protective effect on salivary glands. SUBJECTS AND METHODS: Sixteen patients with differentiated thyroid cancer were prospectively enrolled in the study. Patients after total thyroidectomy, before I treatment, were divided into two groups; 8 patients in the selenium group and 8 patients in the control group. Patients in the selenium group received 300νg of selenium orally for 10 days, from 3 days before to 6 days after I treatment. The control group received a placebo over the same period. To assess salivary gland function, salivary gland scintigraphy was performed before and 6 months after I treatment. Serum amylase and whole blood selenium levels were measured before and 2 days and 6 months after I treatment. Using salivary gland scintigraphy, maximum uptake ratio (MUR), maximum secretion percentage (MSP), and ejection fraction (EF) of each salivary gland were calculated. RESULTS: Baseline clinical characteristics, baseline amylase and selenium levels, and parameters of baseline salivary gland scintigraphy were not significantly different between selenium and control groups (P>0.05). On a blood test performed 2 days after I treatment, the selenium group showed a significantly higher whole blood selenium level (P=0.008) and significantly lower serum amylase level (P=0.009) than the control group. On follow-up salivary gland scintigraphy, the control group showed significantly decreased, MUR of the bilateral parotid and left submandibular glands, MSP of the bilateral parotid and submandibular glands, and EF of the left submandibular glands (P<0.05), while the selenium group only had a significant decrease in MSP of the right submandibular gland and EF of the left submandibular gland (P<0.05). CONCLUSION: Selenium supplementation during I treatment was effective to reduce salivary glands damage by I radiation in patients with differentiated thyroid cancer.
[Mh] Termos MeSH primário: Radioisótopos do Iodo/efeitos adversos
Lesões por Radiação/prevenção & controle
Selênio/administração & dosagem
Sialadenite/etiologia
Sialadenite/prevenção & controle
Neoplasias da Glândula Tireoide/radioterapia
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Suplementos Nutricionais
Feminino
Seres Humanos
Radioisótopos do Iodo/uso terapêutico
Masculino
Meia-Idade
Lesões por Radiação/diagnóstico
Lesões por Radiação/etiologia
Protetores contra Radiação/administração & dosagem
Compostos Radiofarmacêuticos/efeitos adversos
Compostos Radiofarmacêuticos/uso terapêutico
Método Simples-Cego
Neoplasias da Glândula Tireoide/complicações
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radiation-Protective Agents); 0 (Radiopharmaceuticals); H6241UJ22B (Selenium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170320
[St] Status:MEDLINE
[do] DOI:10.1967/s002449910508


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[PMID]:28264210
[Au] Autor:Kurucay M; Werner JO; Bösmüller H; Ioanoviciu SD; Henes J; Horger M
[Ti] Título:[Granulomatosis with Polyangiitis of the Major Salivary Glands].
[Ti] Título:Sialadenitiden bei Granulomatose mit Polyangiitis..
[So] Source:Rofo;189(3):190-192, 2017 03.
[Is] ISSN:1438-9010
[Cp] País de publicação:Germany
[La] Idioma:ger
[Mh] Termos MeSH primário: Granulomatose com Poliangiite/complicações
Granulomatose com Poliangiite/diagnóstico por imagem
Sialadenite/complicações
Sialadenite/diagnóstico por imagem
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Granulomatose com Poliangiite/patologia
Seres Humanos
Sialadenite/patologia
Tomografia Computadorizada por Raios X/métodos
Ultrassonografia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-123227


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[PMID]:28249137
[Au] Autor:Afshar M; Alhussein M
[Ad] Endereço:McGill University, Montreal, QC, Canada m.afshar.h@gmail.com.
[Ti] Título:Iodide-Associated Sialadenitis.
[So] Source:N Engl J Med;376(9):868, 2017 Mar 02.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Meios de Contraste/efeitos adversos
Iodetos/efeitos adversos
Sialadenite/induzido quimicamente
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária
Seres Humanos
Masculino
Pescoço/diagnóstico por imagem
Sialadenite/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Iodides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMicm1609848


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[PMID]:28177730
[Au] Autor:Ittichaicharoen J; Apaijai N; Tanajak P; Sa-Nguanmoo P; Chattipakorn N; Chattipakorn SC
[Ad] Endereço:a Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, 50200, Thailand.
[Ti] Título:Impaired mitochondria and intracellular calcium transients in the salivary glands of obese rats.
[So] Source:Appl Physiol Nutr Metab;42(4):420-429, 2017 Apr.
[Is] ISSN:1715-5320
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect of obese-insulin resistance on salivary glands has not been investigated. We hypothesized that obese-insulin resistance induced by HFD impaired salivary gland function by reducing salivation, increasing inflammation, and fibrosis, as well as impairing mitochondrial function and calcium transient signaling. Male Wistar rats (200-220 g) were fed either a ND or an HFD (n = 8/group) for 16 weeks. At the end of week 16, salivary flow rates, metabolic parameters, and plasma oxidative stress were determined. Rats were then sacrificed and submandibular glands were removed to determine inflammation, fibrosis, apoptosis, mitochondrial function and dynamics, and intracellular calcium transient signaling. Long-term consumption of an HFD caused obese-insulin resistance and increased oxidative stress, fibrosis, inflammation, and apoptosis in the salivary glands. In addition, impaired mitochondrial function, as indicated by increased mitochondrial reactive oxygen species, mitochondrial membrane depolarization, and mitochondrial swelling in salivary glands and impaired intracellular calcium regulation, as indicated by a reduced intracellular calcium transient rising rate, decay rates, and amplitude of salivary acinar cells, were observed in HFD-fed rats. However, salivary flow rate and level of aquaporin 5 protein were not different between both groups. Although HFD consumption did not affect salivation, it caused obese-insulin resistance, leading to pathophysiological alteration of salivary glands, including impaired intracellular calcium transients, increased oxidative stress and inflammation, and salivary mitochondrial dysfunction.
[Mh] Termos MeSH primário: Sinalização do Cálcio
Resistência à Insulina
Mitocôndrias/metabolismo
Obesidade/fisiopatologia
Estado Pré-Diabético/fisiopatologia
Glândulas Salivares/metabolismo
Sialadenite/etiologia
[Mh] Termos MeSH secundário: Células Acinares/imunologia
Células Acinares/metabolismo
Células Acinares/patologia
Células Acinares/ultraestrutura
Animais
Apoptose
Biomarcadores/metabolismo
Dieta Hiperlipídica/efeitos adversos
Fibrose
Masculino
Potencial da Membrana Mitocondrial
Microscopia Eletrônica de Transmissão
Mitocôndrias/imunologia
Mitocôndrias/patologia
Mitocôndrias/ultraestrutura
Dilatação Mitocondrial
Obesidade/imunologia
Obesidade/metabolismo
Obesidade/patologia
Estresse Oxidativo
Estado Pré-Diabético/imunologia
Estado Pré-Diabético/metabolismo
Estado Pré-Diabético/patologia
Distribuição Aleatória
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Glândulas Salivares/imunologia
Glândulas Salivares/patologia
Glândulas Salivares/secreção
Salivação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Reactive Oxygen Species)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1139/apnm-2016-0545


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ARANA-CHAVEZ, Victor Elias
Texto completo
[PMID]:28099448
[Au] Autor:Fukuoka CY; Simões A; Uchiyama T; Arana-Chavez VE; Abiko Y; Kuboyama N; Bhawal UK
[Ad] Endereço:Department of Biomaterials and Oral Biology, São Paulo University, School of Dentistry, São Paulo, Brazil.
[Ti] Título:The Effects of Low-Power Laser Irradiation on Inflammation and Apoptosis in Submandibular Glands of Diabetes-Induced Rats.
[So] Source:PLoS One;12(1):e0169443, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diabetes can lead to dysfunction of the secretory capacity in salivary glands. Activation of the receptor for advanced glycation end products (RAGE) and its ligands has been suggested to participate in chronic disorders such as diabetes and its complications. In this study, the expression of RAGE, high mobility group box 1 (HMGB1) and advanced glycation end products (AGE), as well as the effects of low-power laser irradiation (LPLI) in salivary glands of diabetic rats were evaluated, and the mechanisms involved were characterized. The expression of RAGE and HMGB1 at the protein and mRNA levels was observed in submandibular glands (SMGs) of streptozotocin-induced diabetic rats. A diode laser was applied at 660 nm, 70 mW, 20 J/cm2, 0.56 J/point, with a spot area of 0.028 cm2 and its in vivo effects and the pathways involved were evaluated. Immunohistochemistry and western blotting analysis were performed for inflammatory and apoptosis markers. Diabetes up-regulates HMGB1/AGE/RAGE axis gene expression in SMGs that is associated with activation of the nuclear factor kappa B (NF-κB) pathway. Interestingly, LPLI suppresses NF-κB activation induced by inflammation. LPLI also reduces diabetes-induced apoptosis. That effect was accompanied by decreased levels of Bax, and cleaved caspase 3, which were up-regulated in diabetes. Taken together, our data suggest that LPLI reduces diabetes-induced inflammation by reducing the induction of HMGB1, ultimately leading to inhibition of apoptosis in submandibular glands of diabetic rats.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/complicações
Sialadenite/radioterapia
Glândula Submandibular/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos da radiação
Diabetes Mellitus Experimental/patologia
Feminino
Produtos Finais de Glicação Avançada/metabolismo
Proteína HMGB1/metabolismo
Terapia com Luz de Baixa Intensidade
Ratos
Ratos Wistar
Receptor para Produtos Finais de Glicação Avançada/metabolismo
Sialadenite/metabolismo
Sialadenite/patologia
Glândula Submandibular/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ager protein, rat); 0 (Glycation End Products, Advanced); 0 (HMGB1 Protein); 0 (Hbp1 protein, rat); 0 (Receptor for Advanced Glycation End Products)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169443


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[PMID]:28067896
[Au] Autor:Zhou J; Kawai T; Yu Q
[Ad] Endereço:Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, MA, USA.
[Ti] Título:Pathogenic role of endogenous TNF-α in the development of Sjögren's-like sialadenitis and secretory dysfunction in non-obese diabetic mice.
[So] Source:Lab Invest;97(4):458-467, 2017 Apr.
[Is] ISSN:1530-0307
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients with Sjögren's syndrome (SS), an autoimmune disease primarily affecting exocrine glands, exhibit enhanced TNF-α expression in the saliva and salivary glands. However, the precise in vivo role of TNF-α during the initiation and development of SS is not clearly defined. The present study is undertaken to determine the function of endogenously produced TNF-α in the pathogenesis of SS in non-obese diabetic (NOD) mice, a model of this human disease. Administration of a neutralizing anti-TNF-α antibody to female NOD mice during the stage prior to disease onset significantly improved salivary secretion, indicating a remission of clinical symptoms of SS. TNF-α blockade also decreased the number of leukocyte foci and reduced the number of T cells and B cells in the submandibular glands (SMG). Moreover, TNF-α blockade reduced T-bet protein levels in the SMG, suggesting a decrease in T helper 1 and T cytotoxic 1 cells. These cellular changes induced by TNF-α neutralization were associated with a reduction in T- and B-cell chemoattractants CXCL9 and CXC13. In addition, TNF-α blockade markedly increased the expression level of tight junction protein claudin-1 and water channel protein aquaporin-5, two key factors required for normal salivary secretion, in the SMG. Collectively, these findings indicate that endogenous TNF-α has a pathogenic role in the development of SS in the NOD model of this disease.
[Mh] Termos MeSH primário: Sialadenite/metabolismo
Síndrome de Sjogren/metabolismo
Glândula Submandibular/secreção
Fator de Necrose Tumoral alfa/metabolismo
[Mh] Termos MeSH secundário: Animais
Anticorpos Antinucleares/sangue
Anticorpos Antinucleares/imunologia
Anticorpos Neutralizantes/imunologia
Anticorpos Neutralizantes/farmacologia
Aquaporina 5/metabolismo
Linfócitos B/efeitos dos fármacos
Linfócitos B/metabolismo
Quimiocina CXCL13/genética
Quimiocina CXCL13/metabolismo
Quimiocina CXCL9/genética
Quimiocina CXCL9/metabolismo
Claudina-1/metabolismo
Modelos Animais de Doenças
Feminino
Expressão Gênica/efeitos dos fármacos
Seres Humanos
Camundongos Endogâmicos NOD
Microscopia de Fluorescência
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Saliva/secreção
Sialadenite/patologia
Síndrome de Sjogren/imunologia
Síndrome de Sjogren/patologia
Glândula Submandibular/efeitos dos fármacos
Glândula Submandibular/metabolismo
Linfócitos T/efeitos dos fármacos
Linfócitos T/metabolismo
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Antibodies, Neutralizing); 0 (Aquaporin 5); 0 (Chemokine CXCL13); 0 (Chemokine CXCL9); 0 (Claudin-1); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1038/labinvest.2016.141



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