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  1 / 1005 MEDLINE  
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[PMID]:29458673
[Au] Autor:Morse DJ; Wilson MJ; Wei X; Lewis MAO; Bradshaw DJ; Murdoch C; Williams DW
[Ad] Endereço:1​Oral and Biomedical Sciences, School of Dentistry, Cardiff University, Cardiff, UK.
[Ti] Título:Denture-associated biofilm infection in three-dimensional oral mucosal tissue models.
[So] Source:J Med Microbiol;67(3):364-375, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: In vitro analyses of virulence, pathogenicity and associated host cell responses are important components in the study of biofilm infections. The Candida-related infection, denture-associated oral candidosis, affects up to 60 % of denture wearers and manifests as inflammation of palatal tissues contacting the denture-fitting surface. Commercially available three-dimensional tissue models can be used to study infection, but their use is limited for many academic research institutions, primarily because of the substantial purchase costs. The aim of this study was to develop and evaluate the use of in vitro tissue models to assess infections by biofilms on acrylic surfaces through tissue damage and Candida albicans virulence gene expression. METHODOLOGY: In vitro models were compared against commercially available tissue equivalents (keratinocyte-only, SkinEthic; full-thickness, MatTek Corporation). An in vitro keratinocyte-only tissue was produced using a cancer-derived cell line, TR146, and a full-thickness model incorporating primary fibroblasts and immortalised normal oral keratinocytes was also generated. The in vitro full-thickness tissues incorporated keratinocytes and fibroblasts, and have potential for future further development and analysis. RESULTS: Following polymicrobial infection with biofilms on acrylic surfaces, both in-house developed models were shown to provide equivalent results to the SkinEthic and MatTek models in terms of tissue damage: a significant (P<0.05) increase in LDH activity for mixed species biofilms compared to uninfected control, and no significant difference (P>0.05) in the expression of most C. albicans virulence genes when comparing tissue models of the same type. CONCLUSION: Our results confirm the feasibility and suitability of using these alternative in vitro tissue models for such analyses.
[Mh] Termos MeSH primário: Biofilmes/crescimento & desenvolvimento
Candidíase Bucal/microbiologia
Dentaduras/microbiologia
Interações Hospedeiro-Patógeno
Mucosa Bucal/microbiologia
[Mh] Termos MeSH secundário: Candida albicans/genética
Candida albicans/patogenicidade
Candida albicans/fisiologia
Linhagem Celular
Coinfecção/microbiologia
Fibroblastos/microbiologia
Seres Humanos
Queratinócitos/microbiologia
Polimetil Metacrilato
Estomatite sob Prótese
Virulência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9011-14-7 (Polymethyl Methacrylate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000677


  2 / 1005 MEDLINE  
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[PMID]:29258641
[Au] Autor:Hannah VE; O'Donnell L; Robertson D; Ramage G
[Ti] Título:Denture Stomatitis: Causes, Cures and Prevention.
[So] Source:Prim Dent J;6(4):46-51, 2017 Dec 01.
[Is] ISSN:2050-1684
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Removable dentures are worn by 20% of the UK population and two thirds of these individuals have denture stomatitis. Poor oral hygiene is commonplace among this group, as is smoking and xerostomia, which also contribute to the development of denture stomatitis. A complex polymicrobial biofilm is able to proliferate on the surface of denture materials and matures to form visible denture plaque. This denture plaque biofilm stimulates a local inflammatory process that is detectable clinically as erythema, and hyperplasia. Systemically, denture plaque represents a potential risk factor for systemic disease, in particular aspiration pneumonia. Respiratory pathogens have been detected in the denture plaque and overnight denture wear has been linked to an increased risk of aspiration pneumonia. There is a general lack of evidence on the adequate management of denture stomatitis and we present a protocol for use in the primary care setting.
[Mh] Termos MeSH primário: Odontologia Geral
Higiene Bucal
Estomatite sob Prótese
[Mh] Termos MeSH secundário: Biofilmes
Placa Dentária/complicações
Seres Humanos
Fatores de Risco
Fumar/efeitos adversos
Estomatite sob Prótese/etiologia
Estomatite sob Prótese/microbiologia
Estomatite sob Prótese/prevenção & controle
Estomatite sob Prótese/terapia
Xerostomia/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1308/205016817822230175


  3 / 1005 MEDLINE  
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[PMID]:28685534
[Au] Autor:Javed F; Al-Kheraif AA; Kellesarian SV; Vohra F; Romanos GE
[Ad] Endereço:Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA.
[Ti] Título:Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes.
[So] Source:J Biol Regul Homeost Agents;31(2):343-346, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to assess the oral Candida carriage and species prevalence in denture stomatitis (DS) patients with and without diabetes mellitus (DM). To address the focused question "In patients receiving dentures, how does having diabetes compared to no diabetes influences the carriage and species prevalence of oral Candida?" Indexed databases were explored without time or language restrictions up to and including February 2017. Nine studies were included. In these studies, the number of diabetics ranged between 14 patients and 405 individuals with mean ages ranging between 33 years and 66.4 years. In five studies, the percentage of hyperglycemic patients in the diabetic group ranged from 14.3% to 100%. In one study, all diabetic patients were normoglycemic. Seven studies reported Candida-associated DS to be significantly higher among diabetics than non-diabetics. Candida albicans was the most prevalent species isolated among diabetics and non-diabetics with DS. Denture-wearers with DM are more susceptible to Candida-associated DS as compared to non-diabetics.
[Mh] Termos MeSH primário: Candida albicans
Candidíase/microbiologia
Diabetes Mellitus/microbiologia
Estomatite sob Prótese/microbiologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  4 / 1005 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:28678945
[Au] Autor:Gardizani TP; Pinke KH; Lima HG; Lara VS
[Ad] Endereço:Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Cirurgia, Estomatologia, Patologia e Radiologia. Bauru, SP, Brasil.
[Ti] Título:Phagocytosis and nitric oxide production by peritoneal adherent cells in response to Candida albicans in aging: a collaboration to elucidate the pathogenesis of denture stomatitis.
[So] Source:J Appl Oral Sci;25(3):265-273, 2017 May-Jun.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective: The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans). Material and methods: PAC obtained from young and aged mice were challenged with dead or viable C. albicans by using predetermined proportions (cells:yeast) for 30 and 120 minutes. Phagocytosis was analyzed by acridine orange dye, and NO production by the Griess reaction. Results: C. albicans phagocytosis by PAC from aged mice was similar to that of young mice, although the cells from older mice cells present more internalized fungi compared with matched control. In addition, a tendency towards impaired NO production by peritoneal mononuclear phagocytes from aged mice was observed. Conclusions: PAC from aged mice may capture and store many fungi, which in turn may mean that these cells are effectively unable to eliminate fungi, probably due to impaired NO production. Therefore, considering the important role of C. albicans overgrowth in the pathogenesis of DS and the aspects observed in this study, aging may favor the onset and severity of local candidosis such as DS and its systemic forms.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Candida albicans/patogenicidade
Adesão Celular/fisiologia
Óxido Nítrico/biossíntese
Fagocitose/fisiologia
Estomatite sob Prótese/metabolismo
Estomatite sob Prótese/microbiologia
[Mh] Termos MeSH secundário: Fatores Etários
Animais
Candida albicans/isolamento & purificação
Candidíase/microbiologia
Masculino
Camundongos Endogâmicos C57BL
Óxido Nítrico/análise
Peritônio/citologia
Valores de Referência
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE


  5 / 1005 MEDLINE  
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[PMID]:28493889
[Au] Autor:Madariaga-Venegas F; Fernández-Soto R; Duarte LF; Suarez N; Delgadillo D; Jara JA; Fernández-Ramires R; Urzúa B; Molina-Berríos A
[Ad] Endereço:Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago, Chile.
[Ti] Título:Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients.
[So] Source:PLoS One;12(5):e0176755, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Candida albicans biofilms play a key role in denture stomatitis, one of the most common oral pathologies in elderly people. Because biofilms are highly resistant to antifungals, new pharmacological strategies are needed. Aspirin and nitric oxide-donor molecules have both shown antibiofilm effects on C. albicans, making them promising candidates for treatment. In this study, we evaluated the antifungal/antibiofilm effect of a nitric-oxide releasing aspirin (NO-ASA) on C. albicans isolates from denture stomatitis patients in vitro. Disk diffusion assays showed that while NO-ASA had no antifungal effect, the drug potentiated fluconazole inhibition zone diameters, increasing the effect of fluconazole by 20-30% (p<0.05). The effect of NO-ASA on the morphogenesis of C. albicans was evaluated using light microscopy after inducing hyphae formation. For all clinical strains assayed, 125 µM NO-ASA significantly decreased the number of filamentous cells present (p<0.01). Adhesion to abiotic surfaces, a critical event for biofilm formation, was evaluated in 96-well polystyrene plates using crystal violet assay; 125 µM NO-ASA significantly inhibited adhesion. Biofilms were observed with scanning electron microscopy (SEM) and quantified using XTT reduction assay. NO-ASA decreased biofilm formation (IC50 ranging from 300 µM to 700 µM), consistent with SEM findings of altered biofilm microarchitecture. PGE2 and carboxy-PTIO (an NO scavenger) both blocked the antibiofilm effects of NO-ASA, suggesting that the efficacy of NO-ASA may be associated with both inhibition of PGE2 synthesis and release of NO. NO-ASA is a promising novel antibiofilm agent for treating fluconazole-resistant strains of C. albicans.
[Mh] Termos MeSH primário: Aspirina/análogos & derivados
Biofilmes/efeitos dos fármacos
Candida albicans/isolamento & purificação
Nitrocompostos/farmacologia
Estomatite sob Prótese/microbiologia
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Antifúngicos/uso terapêutico
Aspirina/farmacologia
Aspirina/uso terapêutico
Aderência Bacteriana/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Candida albicans/ultraestrutura
Dinoprostona/metabolismo
Farmacorresistência Fúngica/efeitos dos fármacos
Fluconazol/farmacologia
Fluconazol/uso terapêutico
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Concentração Inibidora 50
Viabilidade Microbiana/efeitos dos fármacos
Nitrocompostos/uso terapêutico
Estomatite sob Prótese/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Free Radical Scavengers); 0 (NCX 4040); 0 (Nitro Compounds); 8VZV102JFY (Fluconazole); EH04H13L6B (nitroaspirin); K7Q1JQR04M (Dinoprostone); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176755


  6 / 1005 MEDLINE  
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[PMID]:28115357
[Au] Autor:Herman JL; Wang Y; Lilly EA; Lallier TE; Peters BM; Hamdan S; Xu X; Fidel PL; Noverr MC
[Ad] Endereço:Department of Periodontics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
[Ti] Título:Synthesis, Antifungal Activity, and Biocompatibility of Novel 1,4-Diazabicyclo[2.2.2]Octane (DABCO) Compounds and DABCO-Containing Denture Base Resins.
[So] Source:Antimicrob Agents Chemother;61(4), 2017 Apr.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The fungal pathogen causes a variety of oral infections, including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Our laboratory synthesized novel derivatives of 1,4-diazabicyclo[2.2.2]octane (DABCO), which is an organic compound typically used as a catalyst in polymerization reactions. DABCO derivatives with different aliphatic chain lengths (DC16, DC16F, DC18, and C6DC16), as well as methacrylate monomers conjugated to DABCO compounds (DC11MAF and C2DC11MAF), were synthesized and tested for antimicrobial activity. All the compounds exhibited fungicidal activity against several species at concentrations ranging between 2 and 4 µg/ml. Moreover, acrylic denture base resins fabricated to contain 1, 2, or 4 wt% DABCO compounds inhibited surface biofilm formation, as well as fungal growth, in disc diffusion assays. Remarkably, discs (4 wt%) aged for 2 months also exhibited approximately 100% growth-inhibitory activity. While some DABCO compounds exerted intermediate to high cytotoxicity against mammalian oral cell types, DC11MAF and denture base resin discs containing 2 or 4 wt% C2DC11MAF exhibited relatively low cytotoxicity against periodontal ligament (PDL) cell and gingival fibroblast (GF) lines, as well as primary oral epithelial cells. These studies demonstrate that DABCO derivatives can be incorporated into denture materials and exert fungicidal activity with minimal cytotoxicity to mammalian cells. DC11MAF and C2DC11MAF are considered strong candidates as therapeutic or preventive alternatives against -associated denture stomatitis.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Bases de Dentadura
Piperazinas/farmacologia
[Mh] Termos MeSH secundário: Biofilmes/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estomatite sob Prótese/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Piperazines); X8M57R0JS5 (triethylenediamine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE


  7 / 1005 MEDLINE  
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[PMID]:28032543
[Au] Autor:O'Donnell LE; Alalwan HK; Kean R; Calvert G; Nile CJ; Lappin DF; Robertson D; Williams C; Ramage G; Sherry L
[Ad] Endereço:1​Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
[Ti] Título:Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity.
[So] Source:J Med Microbiol;66(1):54-60, 2017 Jan.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Approximately 20 % of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm -forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment and to assess antimicrobial activity of common denture cleansers against these tenacious communities. C. albicans isolated from dentures of healthy and diseased individuals was quantified using real-time PCR and biofilm biomass assessed using crystal violet. Biofilm development on the denture substratum poly(methyl methacrylate), Molloplast B and Ufi-gel was determined. Biofilm formation was assessed using metabolic and biomass stains, following treatment with denture hygiene products. Although C. albicans was detected in greater quantities in diseased individuals, it was not associated with increased biofilm biomass. Denture substrata were shown to influence biofilm biomass, with poly(methyl methacrylate) providing the most suitable environment for C. albicans to reside. Of all denture hygiene products tested, Milton had the most effective antimicrobial activity, reducing biofilm biomass and viability the greatest. Overall, our results highlight the complex nature of denture- related disease, and disease development cannot always be attributed to a sole cause. It is the distinct combination of various factors that ultimately determines the pathogenic outcome.
[Mh] Termos MeSH primário: Biofilmes
Candida albicans/crescimento & desenvolvimento
Higienizadores de Dentadura/farmacologia
Dentaduras/microbiologia
Estomatite sob Prótese/microbiologia
[Mh] Termos MeSH secundário: Antifúngicos/farmacologia
Candida albicans/efeitos dos fármacos
Estudos de Casos e Controles
Contagem de Colônia Microbiana
Seres Humanos
Viabilidade Microbiana/efeitos dos fármacos
Polimetil Metacrilato/química
Reação em Cadeia da Polimerase em Tempo Real
Propriedades de Superfície/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Denture Cleansers); 9011-14-7 (Polymethyl Methacrylate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000419


  8 / 1005 MEDLINE  
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[PMID]:27920509
[Au] Autor:Loster JE; Wieczorek A; Loster BW
[Ad] Endereço:Department of Dental Prosthetics.
[Ti] Título:Correlation between age and gender in species infections of complete denture wearers: a retrospective analysis.
[So] Source:Clin Interv Aging;11:1707-1714, 2016.
[Is] ISSN:1178-1998
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:AIM: Denture-related stomatitis is a disorder that often affects denture wearers. The purpose of this study was to evaluate the intensity, genera, and frequency of yeasts in the oral cavity of complete denture wearers in terms of subject gender and age. MATERIALS AND METHODS: Nine hundred twenty patients (307 males and 613 females) with complete upper dentures were selected for the study and divided into four age groups: ≤50 years, 51-60, 61-70, and >70 years. Yeast samples were taken as a smear from the palate. The data were collected from January 15, 2007 to January 15, 2012. RESULTS: The distribution of the number of yeast colonies by gender was statistically significant ( =0.02). Across all subjects, there was a statistically significant relationship between the intensity of yeast growth and the gender ( =0.01). In every age group, the number of infection-free individuals was greater among males than females. Intermediate, intense, and abundant growth of yeast occurred most frequently in the youngest group of females. CONCLUSION: The genera of species and the frequency of yeast infection in denture wearers appear to be influenced by both age and gender. The complete denture wearers ≤50 years of age appeared to have the greatest proclivity to oral infections.
[Mh] Termos MeSH primário: Fatores Etários
Candida/isolamento & purificação
Prótese Total/microbiologia
Boca/microbiologia
Fatores Sexuais
Estomatite sob Prótese/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Candida/classificação
Feminino
Seres Humanos
Masculino
Meia-Idade
Polônia/epidemiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE


  9 / 1005 MEDLINE  
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[PMID]:27889906
[Au] Autor:Hilgert JB; Giordani JM; de Souza RF; Wendland EM; D'Avila OP; Hugo FN
[Ad] Endereço:Postgraduate Program in Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
[Ti] Título:Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta-Analysis.
[So] Source:J Am Geriatr Soc;64(12):2539-2545, 2016 Dec.
[Is] ISSN:1532-5415
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To assess the effectiveness of different interventions for treating or preventing denture stomatitis (DS). DESIGN: Systematic review. SETTING: Randomized controlled trials (RCTs) comparing any agent or procedure prescribed to treat or prevent DS in adults. PARTICIPANTS: Older adults with denture stomatitis. MEASUREMENTS: There were two main outcomes reported in the trials included in this review: clinical signs of DS and remaining presence of yeast. There were no restrictions regarding language or date of publication. The search period was up to February 2016. RESULTS: Thirty-five studies were included in the systematic review, with 32 judged as having high risk of bias. Three RCTs compared nystatin with placebo and found a significant effect on the reduction of clinical signs of stomatitis (risk ratio (RR) = 0.51, 95% confidence interval (CI) = 0.36-0.72), four RCTs compared nystatin with placebo and found a significant effect on mycological assessment (RR = 0.61, 95% CI = 0.46-0.80). Five studies of disinfectant agents also showed a significant effect in comparison with an inactive agent (RR = 0.52, 95% CI = 0.30-0.92) in clinical assessment. No evidence was found of an effect of miconazole, amphotericin, or imidazolic drugs. No RCT evaluated the effectiveness of preventive approaches. CONCLUSION: The results are supportive of the use of nystatin and disinfecting agents in the treatment of DS, but clinicians need to be aware that individual studies had high risk of bias and that the overall quality of the individual reports was judged to be low.
[Mh] Termos MeSH primário: Estomatite sob Prótese/terapia
[Mh] Termos MeSH secundário: Seres Humanos
Ensaios Clínicos Controlados Aleatórios como Assunto
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161128
[St] Status:MEDLINE
[do] DOI:10.1111/jgs.14399


  10 / 1005 MEDLINE  
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Texto completo SciELO Brasil
[PMID]:27812610
[Au] Autor:Neppelenbroek KH
[Ad] Endereço:Editor-in-Chief, Journal of Applied Oral Science.
[Ti] Título:Sustained drug-delivery system: a promising therapy for denture stomatitis?
[So] Source:J Appl Oral Sci;24(5):420-422, 2016 Sep-Oct.
[Is] ISSN:1678-7765
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Mh] Termos MeSH primário: Anti-Infecciosos/administração & dosagem
Antifúngicos/administração & dosagem
Sistemas de Liberação de Medicamentos/métodos
Estomatite sob Prótese/tratamento farmacológico
[Mh] Termos MeSH secundário: Reembasadores de Dentadura
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antifungal Agents)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE



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