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[PMID]:29407495
[Au] Autor:Barber S; Bekker HL; Meads D; Pavitt S; Khambay B
[Ad] Endereço:Department of Orthodontics, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom. Electronic address: sophybarber@nhs.net.
[Ti] Título:Identification and appraisal of outcome measures used to evaluate hypodontia care: A systematic review.
[So] Source:Am J Orthod Dentofacial Orthop;153(2):184-194.e18, 2018 Feb.
[Is] ISSN:1097-6752
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Identification and appraisal of the outcome measures that have been used to evaluate hypodontia treatment and deliver services are essential for improving care. A lack of alignment between outcomes and patient values can limit the scope for patient-centered care. Our objectives were to identify and appraise the outcomes selected to evaluate hypodontia care. METHODS: Data sources included 10 electronic databases and grey literature, searched using terms for hypodontia and its treatment methods. Study eligibility included mixed study designs to ensure comprehensive identification of outcomes, excluding case reports and case series with fewer than 10 participants and nonsystematic reviews. Participants and interventions involved people with hypodontia receiving any dental treatment to manage their hypodontia. Simulated treatment, purely laboratory-based interventions, and future treatments still in development were excluded. Research outcomes were identified and synthesised into 4 categories: clinical indicators, and patient-reported, clinician-reported, and lay-reported outcomes. No synthesis of efficacy data was planned, and consequently no methodologic quality appraisal of the studies was undertaken. RESULTS: The search identified 497 abstracts, from which 106 eligible articles were retrieved in full. Fifty-six studies and 8 quality-improvement reports were included. Clinical indicators were reported in 49 studies (88%) including appearance, function, dental health, treatment longevity, treatment success and service delivery. Patient-reported outcomes were given in 22 studies (39%) including oral health-related quality of life, appearance, function, symptoms of temporomandibular dysfunction, and patient experience. Clinician-reported outcomes were limited to appearance. Variability was seen in the tools used for measuring outcomes. CONCLUSIONS: There is a lack of rationale and consistency in the selection of outcome measures used to evaluate hypodontia care. Outcomes are largely clinician and researcher-driven with little evidence of their relevance to patients. There was a paucity of outcomes measuring access to care, quality of care, and cost. Evidence from hypodontia research is clinician-focused and likely to have limited value to support patients during decision making. Attempts to synthesise the evidence base for translation into practice will be challenging. There is a need for a core outcomes set with a patient-centric approach to drive improvements in health services.
[Mh] Termos MeSH primário: Anodontia/terapia
Assistência Odontológica/normas
Garantia da Qualidade dos Cuidados de Saúde/métodos
[Mh] Termos MeSH secundário: Assistência Odontológica/métodos
Seres Humanos
Garantia da Qualidade dos Cuidados de Saúde/normas
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29178643
[Au] Autor:Yuan Q; Zhao M; Tandon B; Maili L; Liu X; Zhang A; Baugh EH; Tran T; Silva RM; Hecht JT; Swindell EC; Wagner DS; Letra A
[Ad] Endereço:Department of Pediatrics, University of Texas Health Science Center at Houston Medical School, Houston, Texas.
[Ti] Título:Role of WNT10A in failure of tooth development in humans and zebrafish.
[So] Source:Mol Genet Genomic Med;5(6):730-741, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Oligodontia is a severe form of tooth agenesis characterized by the absence of six or more permanent teeth. Oligodontia has complex etiology and variations in numerous genes have been suggested as causal for the condition. METHODS: We applied whole-exome sequencing (WES) to identify the cause of oligodontia in a 9-year-old girl missing 11 permanent teeth. Protein modeling and functional analysis in zebrafish were also performed to understand the impact of identified variants on the phenotype. RESULTS: We identified a novel compound heterozygous missense mutation in WNT10A (c.637G>A:p.Gly213Ser and c.1070C>T:p.Thr357Ile) as the likely cause of autosomal recessive oligodontia in the child. Affected residues are located in conserved regions and variants are predicted to be highly deleterious for potentially destabilizing the protein fold and inhibiting normal protein function. Functional studies in zebrafish embryos showed that wnt10a is expressed in the craniofacies at critical time points for tooth development, and that perturbations of wnt10a expression impaired normal tooth development and arrested tooth development at 5 days postfertilization (dpf). Furthermore, mRNA expression levels of additional tooth development genes were directly correlated with wnt10a expression; expression of msx1, dlx2b, eda, and axin2 was decreased upon wnt10a knockdown, and increased upon wnt10a overexpression. CONCLUSIONS: Our results reveal a novel compound heterozygous variant in WNT10A as pathogenic for oligodontia, and demonstrate that perturbations of wnt10a expression in zebrafish may directly and/or indirectly affect tooth development recapitulating the agenesis phenotype observed in humans.
[Mh] Termos MeSH primário: Anodontia/genética
Dente/crescimento & desenvolvimento
Proteínas Wnt/genética
Proteínas de Peixe-Zebra/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Animais Geneticamente Modificados/genética
Anodontia/diagnóstico
Sequência de Bases
Criança
Dentição Permanente
Embrião não Mamífero/metabolismo
Feminino
Heterozigoto
Seres Humanos
Modelos Animais
Morfolinos/genética
Morfolinos/metabolismo
Fenótipo
Estrutura Terciária de Proteína
Dente/patologia
Sequenciamento Completo do Exoma
Proteínas Wnt/química
Proteínas Wnt/metabolismo
Peixe-Zebra/genética
Proteínas de Peixe-Zebra/antagonistas & inibidores
Proteínas de Peixe-Zebra/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Morpholinos); 0 (WNT10A protein, human); 0 (Wnt Proteins); 0 (Zebrafish Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.332


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[PMID]:29185301
[Au] Autor:Simos S
[Ti] Título:Anterior Tooth Replacement Made Easy: A Conservative and Predictable Direct Technique.
[So] Source:Dent Today;35(9):80, 82-3, 2016 Sep.
[Is] ISSN:8750-2186
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anodontia/cirurgia
Prótese Parcial Fixa
[Mh] Termos MeSH secundário: Adulto
Estética Dentária
Feminino
Seres Humanos
Satisfação do Paciente
Clareamento Dental
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE


  4 / 3324 MEDLINE  
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[PMID]:28877528
[Au] Autor:Savasta S; Carlone G; Castagnoli R; Chiappe F; Bassanese F; Piras R; Salpietro V; Brazzelli V; Verrotti A; Marseglia GL
[Ad] Endereço:Department of Pediatrics, Fondazione Policlinico San Matteo IRCCS, University of Pavia, Pavia, Italy.
[Ti] Título:X-Linked Hypohidrotic Ectodermal Dysplasia: New Features and a Novel EDA Gene Mutation.
[So] Source:Cytogenet Genome Res;152(3):111-116, 2017.
[Is] ISSN:1424-859X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We described a 5-year-old male with hypodontia, hypohidrosis, and facial dysmorphisms characterized by a depressed nasal bridge, maxillary hypoplasia, and protuberant lips. Chromosomal analysis revealed a normal 46,XY male karyotype. Due to the presence of clinical features of hypohidrotic ectodermal dysplasia (HED), the EDA gene, located at Xq12q13.1, of the patient and his family was sequenced. Analysis of the proband's sequence revealed a missense mutation (T to A transversion) in hemizygosity state at nucleotide position 158 in exon 1 of the EDA gene, which changes codon 53 from leucine to histidine, while heterozygosity at this position was detected in the slightly affected mother; moreover, this mutation was not found in the publically available Human Gene Mutation Database. To date, our findings indicate that a novel mutation in EDA is associated with X-linked HED, adding it to the repertoire of EDA mutations.
[Mh] Termos MeSH primário: Displasia Ectodérmica Anidrótica Tipo 1/genética
Ectodisplasinas/genética
Mutação de Sentido Incorreto
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Anodontia/genética
Anodontia/patologia
Pré-Escolar
Códon
Análise Mutacional de DNA
Displasia Ectodérmica Anidrótica Tipo 1/patologia
Feminino
Genes Ligados ao Cromossomo X
Hemizigoto
Heterozigoto
Histidina/genética
Seres Humanos
Hipo-Hidrose/genética
Hipo-Hidrose/patologia
Leucina/genética
Lábio/anormalidades
Masculino
Maxila/anormalidades
Osso Nasal/anormalidades
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon); 0 (EDA protein, human); 0 (Ectodysplasins); 4QD397987E (Histidine); GMW67QNF9C (Leucine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1159/000478922


  5 / 3324 MEDLINE  
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[PMID]:28847717
[Au] Autor:Sarkar T; Bansal R; Das P
[Ad] Endereço:Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, India.
[Ti] Título:A novel G to A transition at initiation codon and exon-intron boundary of PAX9 identified in association with familial isolated oligodontia.
[So] Source:Gene;635:69-76, 2017 Nov 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Several studies on experimental animals indicate that the process of organogenesis crucially depends upon the spatiotemporal dose of certain critical bio-molecules. Tooth development is also not an exception. While most of the knowledge regarding the molecular mechanism of tooth development comes from the studies on mouse model, pathogenic variations identified in human tooth agenesis also provide valuable information on mammalian tooth development. Until now five major candidate genes have been identified for tooth agenesis in human. Among them, PAX9 plays the crucial role in tooth development and in non-syndromic congenital tooth agenesis. In this study, microsatellite and SNP based genotyping identifies a disease specific haplotype block, which includes PAX9 gene, segregates with autosomal dominant tooth agenesis phenotype. Direct sequencing of PAX9 identifies a novel heterozygous G to A transition at the third base (c.3G>A) of initiation codon leading to ATG to ATA shift in all affected individuals which is absent in all unaffected relatives and 200 control chromosomes. Further, in vitro functional analysis creating PAX9 minigene construct did apparently show no effect on the splice-site migration. It is therefore proposed that haploinsufficiency of PAX9 is the causal factor for tooth agenesis in this family.
[Mh] Termos MeSH primário: Anodontia/genética
Predisposição Genética para Doença
Fator de Transcrição PAX9/genética
Dente/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Anodontia/fisiopatologia
Genótipo
Haplótipos
Seres Humanos
Camundongos
Mutação
Organogênese/genética
Polimorfismo de Nucleotídeo Único
Dente/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PAX9 Transcription Factor); 0 (PAX9 protein, human)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


  6 / 3324 MEDLINE  
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[PMID]:28783411
[Au] Autor:Juuri E; Balic A
[Ad] Endereço:1 Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
[Ti] Título:The Biology Underlying Abnormalities of Tooth Number in Humans.
[So] Source:J Dent Res;96(11):1248-1256, 2017 Oct.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In past decades, morphologic, molecular, and cellular mechanisms that govern tooth development have been extensively studied. These studies demonstrated that the same signaling pathways regulate development of the primary and successional teeth. Mutations of these pathways lead to abnormalities in tooth development and number, including aberrant tooth shape, tooth agenesis, and formation of extra teeth. Here, we summarize the current knowledge on the development of the primary and successional teeth in animal models and describe some of the common tooth abnormalities in humans.
[Mh] Termos MeSH primário: Anormalidades Dentárias/embriologia
[Mh] Termos MeSH secundário: Animais
Anodontia/embriologia
Seres Humanos
Morfogênese
Odontogênese
Transdução de Sinais
Dente Supranumerário/embriologia
Fatores de Transcrição/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517720158


  7 / 3324 MEDLINE  
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[PMID]:28668944
[Au] Autor:Derton N; Lupini D; Cozzani M
[Ad] Endereço:Private Practice of Orthodontics, Conegliano, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
[Ti] Título:Miniscrew-Supported Orthodontic Pseudo-Ankylosis for Mesialization of a Lower Third Molar.
[So] Source:J Clin Orthod;51(5):290-293, 2017 May.
[Is] ISSN:0022-3875
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anodontia/terapia
Movimento Mesial dos Dentes/terapia
Procedimentos de Ancoragem Ortodôntica/instrumentação
Fechamento de Espaço Ortodôntico/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Má Oclusão/terapia
Má Oclusão de Angle Classe I/terapia
Dente Serotino
Desenho de Aparelho Ortodôntico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  8 / 3324 MEDLINE  
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[PMID]:28597840
[Au] Autor:Benkaddour A; Benyahia H; Mohtarim BE; Zaoui F
[Ad] Endereço:Faculté de médecine dentaire, Université Mohamed V, Rabat Instituts, BP 6212, Maroc.
[Ti] Título:[How to treat hypoplasia of the lateral upper incisors by canine substitution : a clinical case].
[Ti] Título:Traitement de l'hypoplasie des incisives latérales maxillaires par substitution canine. A propos d'un cas clinique..
[So] Source:Orthod Fr;88(2):199-208, 2017 Jun.
[Is] ISSN:0078-6608
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Facing a patient with a morphological or numerical disorder of the lateral upper incisors (mainly pegged or missing incisor), the orthodontist has to choose between two treatment options : either spatial planning for a prosthetic restoration, or space closure with substitution of the lateral incisors by canines; the choice depends on the clinical context we are faced with. Each treatment option has its advantages and disadvantages and it is hard to tip the balance in one direction or another. MATERIAL AND METHOD: This article illustrates the rationale for therapeutic management of space closure, in a patient with skeletal class III, with hypoplastic and peg-shaped upper lateral incisors.
[Mh] Termos MeSH primário: Anodontia/terapia
Incisivo/anormalidades
Má Oclusão de Angle Classe III/terapia
Fechamento de Espaço Ortodôntico
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1051/orthodfr/2017012


  9 / 3324 MEDLINE  
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[PMID]:28535361
[Au] Autor:Al-Ani AH; Antoun JS; Thomson WM; Merriman TR; Farella M
[Ad] Endereço:1 Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
[Ti] Título:Maternal Smoking during Pregnancy Is Associated with Offspring Hypodontia.
[So] Source:J Dent Res;96(9):1014-1019, 2017 Aug.
[Is] ISSN:1544-0591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Little is known about environmental risk factors for hypodontia. The objective of this study was to investigate the association between hypodontia and common environmental risk factors, such as maternal smoking and alcohol and caffeine consumption during pregnancy. Eighty-nine hypodontia cases with 1 or more missing permanent lateral incisors and/or 1 or more missing premolars were enrolled in this clinic-based case-control study. Some 253 controls with no missing teeth were frequency matched to cases by age and sex. Hypodontia was diagnosed using panoramic radiographs. Sociodemographic data were collected from both the participants and their mothers, with maternal self-reported active and passive smoking, as well as alcohol and caffeine consumption during pregnancy, assessed by a questionnaire. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with logistic regression to assess the strength of association between risk factors and hypodontia. OR estimates were then adjusted for possible confounders, such as maternal age at delivery, sex and gestational age of the child, and household socioeconomic background. Significant associations were found between hypodontia and maternal cigarette use during pregnancy, as well as the number of cigarettes smoked per day. The consumption of 10 or more cigarettes per day during pregnancy was associated with greater odds of having a child with hypodontia (adjusted OR, 4.18; 95% CI, 1.48-11.80; P = 0.007). Observed associations between hypodontia, second-hand smoke, and alcohol and caffeine consumption were not statistically significant. Maternal smoking during pregnancy is associated with hypodontia. Larger samples and prospective observational study designs, however, are needed to investigate this association further.
[Mh] Termos MeSH primário: Anodontia/etiologia
Mães
Efeitos Tardios da Exposição Pré-Natal
Fumar/efeitos adversos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Consumo de Bebidas Alcoólicas/efeitos adversos
Anodontia/diagnóstico por imagem
Cafeína/efeitos adversos
Estudos de Casos e Controles
Feminino
Idade Gestacional
Seres Humanos
Masculino
Idade Materna
Gravidez
Radiografia Panorâmica
Fatores de Risco
Fatores Socioeconômicos
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3G6A5W338E (Caffeine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.1177/0022034517711156


  10 / 3324 MEDLINE  
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[PMID]:28474070
[Au] Autor:Chen YN; Zheng BW; Liu Y
[Ad] Endereço:Fengtian Dental Clinic,School of Stomatology,China Medical University; Institute of Dental Research of Liaoning Province. Shenyang 110013, Liaoning Province, China. E-mail:276262718@qq.com.
[Ti] Título:[Study of the relationship between congenital missing of the third molar and the development of the mandibular angle].
[So] Source:Shanghai Kou Qiang Yi Xue;26(1):69-72, 2017 Feb.
[Is] ISSN:1006-7248
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:PURPOSE: Based on the research of the congenital missing of the third molar and the missing number, the relationship beteen congenital missing of the third molar and the development of the mandibular angle was evaluated. METHODS: Patients were divided into experimental group and control group, the experimental group included 227 patients, each had at least one of the third molars congenital lost; 227 patients who had four third molar were selected as control group. Winceph software was used to measure the lateral cephalograms. SPSS17.0 software package was used to perform statistical analysis. RESULTS: Gonial angle, upper Gonial angle and lower Gonial angle between the experimental group and the control group showed significant difference and the values in the experimental group were significantly smaller than in the control group, but there was no gender difference between the two groups.There was no difference between Gonial angle, upper Gonial angle,lower Gonial angle and the missing number of the third molar. CONCLUSIONS: There is a close relationship between congenital missing third molar and Gonial angle, upper Gonial angle, lower Gonial angle, but there is no significant association with gender and the patients with congenital missing third molar have shorter craniofacial structure. Congenital missing number of the third molar has no significant association with Gonial angle, upper Gonial angle and lower Gonial angle.
[Mh] Termos MeSH primário: Anodontia
Mandíbula/fisiologia
Dente Serotino
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170506
[St] Status:MEDLINE



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