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  1 / 1709 MEDLINE  
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[PMID]:28450590
[Au] Autor:Gibbons A
[Ad] Endereço:New Orleans, Louisiana.
[Ti] Título:In surprise, tooth decay afflicts hunter-gatherers.
[So] Source:Science;356(6336):362, 2017 Apr 28.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cárie Dentária/história
Dieta/efeitos adversos
Saúde Bucal/história
[Mh] Termos MeSH secundário: Antropologia
Cárie Dentária/patologia
Hipoplasia do Esmalte Dentário/história
Hipoplasia do Esmalte Dentário/patologia
Feminino
Ficus/efeitos adversos
História Antiga
Mel/efeitos adversos
Seres Humanos
Masculino
Tanzânia
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1126/science.356.6336.362


  2 / 1709 MEDLINE  
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[PMID]:29068616
[Ti] Título:Genetic Defects in Tooth Enamel Can Lead to Cavities.
[So] Source:J Calif Dent Assoc;45(4):174, 2017 04.
[Is] ISSN:1043-2256
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cárie Dentária
Esmalte Dentário
[Mh] Termos MeSH secundário: Hipoplasia do Esmalte Dentário
Seres Humanos
[Pt] Tipo de publicação:NEWS; COMMENT
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE


  3 / 1709 MEDLINE  
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[PMID]:28872993
[Au] Autor:Sönmez H; Saat S
[Ti] Título:A Clinical Evaluation of Deproteinization and Different Cavity Designs on Resin Restoration Performance in MIH-Affected Molars: Two-Year Results.
[So] Source:J Clin Pediatr Dent;41(5):336-342, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to evaluate the clinical effects of deproteinization of the hypomineralized enamel and different cavity designs on the performance of the composite resin restorations(CRRs) placed into the cavities of MIH (molar incisor hypomineralization)-affected molars. STUDY DESIGN: 95 MIH-affected permanent first molars (PFMs) and 31 caries but not MIH-affected PFMs (126 teeth in total) were included in the study. The MIH-affected molars were divided into three groups. In Group I, all hypomineralized tissue was removed until healthy enamel was reached. In Group II, carious and cheesy hypomineralized tissue was removed until a reasonable resistance was detected in the hypomineralized tissue. In Group III, cavities designed as Group II, differently from this group deproteinization of the left hypomineralized tissue was performed prior to the placement of CRRs. Group IV served as the control group consisting of unaffected carious PFMs. Restorations were evaluated according to modified USPHS criteria for 24 months. RESULTS: The retention rates were 93.7% for Group I, 80.7% for Group II, 93.5% for Group III and 100% for Group IV. The success rate for the restorations in Group II proved significantly lower (p<0.05) than that of the other three groups. No significant difference in success rates was observed between Group I, Group III and Group IV (p>0.05) at the end of 24 months. CONCLUSIONS: Failure of the restorations was predominant in the group that the hypomineralized tissue was left surrounding the cavities. Deproteinization of the hypomineralized enamel was found to enhance the retention rates of CRRs.
[Mh] Termos MeSH primário: Resinas Compostas
Hipoplasia do Esmalte Dentário/terapia
Corrosão Dentária
Restauração Dentária Permanente
[Mh] Termos MeSH secundário: Criança
Proteínas do Esmalte Dentário/efeitos dos fármacos
Materiais Dentários
Seres Humanos
Ácidos Fosfóricos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Composite Resins); 0 (Dental Enamel Proteins); 0 (Dental Materials); 0 (Phosphoric Acids); E4GA8884NN (phosphoric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.5.336


  4 / 1709 MEDLINE  
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[PMID]:28752513
[Au] Autor:Masterson EE; Fitzpatrick AL; Enquobahrie DA; Mancl LA; Conde E; Hujoel PP
[Ad] Endereço:School of Dentistry, Department of Oral Health Sciences, University of Washington, Seattle, Washington, DC, 98119.
[Ti] Título:Malnutrition-related early childhood exposures and enamel defects in the permanent dentition: A longitudinal study from the Bolivian Amazon.
[So] Source:Am J Phys Anthropol;164(2):416-423, 2017 Oct.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We investigated the relationship between early childhood malnutrition-related measures and subsequent enamel defects in the permanent dentition. MATERIALS AND METHODS: This cohort study included 349 Amerindian adolescents (10-17 years, 52% male) from the Bolivian Amazon. Exposures included: stunted growth (height-for-age z-scores), underweight (weight-for-age z-scores), anemia (hemoglobin), acute inflammation (C-reactive protein) and parasitic infection (hookworm). We measured the occurrence (no/yes) and extent (<1/3, 1/3-2/3, >2/3) of enamel defects. We estimated associations between childhood exposures and enamel defect measures using log-binomial and multinomial logistic regression. RESULTS: The prevalence of an enamel defect characterized by an orange peel texture on a large central depression on the labial surface of the central maxillary incisors was 92.3%. During childhood (1-4 years), participants had a high prevalence of stunted growth (75.2%), anemia (56.9%), acute inflammation (39.1%), and hookworm infection (49.6%). We observed associations between childhood height-for-age (OR = 0.65; P = 0.028 for >2/3 extent vs. no EH) and gastrointestinal hookworm infection (OR = 3.43; P = 0.035 for >2/3 extent vs. no defects or <1/3 extent) with enamel defects. DISCUSSION: The study describes a possibly novel form of enamel hypoplasia and provides evidence for associations of malnutrition-related measures in early childhood, including stunted growth and parasitic helminth infection, with the observed enamel defects.
[Mh] Termos MeSH primário: Hipoplasia do Esmalte Dentário
Desnutrição
[Mh] Termos MeSH secundário: Adolescente
Antropologia Física
Bolívia/epidemiologia
Criança
Pré-Escolar
Hipoplasia do Esmalte Dentário/epidemiologia
Hipoplasia do Esmalte Dentário/etiologia
Hipoplasia do Esmalte Dentário/patologia
Dentição Permanente
Feminino
Transtornos do Crescimento
Seres Humanos
Índios Sul-Americanos/estatística & dados numéricos
Lactente
Estudos Longitudinais
Masculino
Desnutrição/complicações
Desnutrição/epidemiologia
Dente/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23283


  5 / 1709 MEDLINE  
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[PMID]:28683959
[Au] Autor:Proust-Lemoine E; Guyot S
[Ad] Endereço:Endocrinologie, polyclinique Aguilera, 21, rue de l'Estagnas, 64200 Biarritz, France. Electronic address: e.proustlemoine@yahoo.fr.
[Ti] Título:[Oral diseases in auto-immune polyendocrine syndrome type 1].
[Ti] Título:Polyendocrinopathies auto-immunes de type 1 et pathologies buccales..
[So] Source:Presse Med;46(9):853-863, 2017 Sep.
[Is] ISSN:2213-0276
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:Auto-immune polyendocrine syndrome type 1 (APS1) also called Auto-immune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare monogenic childhood-onset auto-immune disease. This autosomal recessive disorder is caused by mutations in the auto-immune regulator (AIRE) gene, and leads to autoimmunity targeting peripheral tissues. There is a wide variability in clinical phenotypes in patients with APSI, with auto-immune endocrine and non-endocrine disorders, and chronic mucocutaneous candidiasis. These patients suffer from oral diseases such as dental enamel hypoplasia and candidiasis. Both are frequently described, and in recent series, enamel hypoplasia and candidiasis are even the most frequent components of APS1 together with hypoparathyroidism. Both often occur during childhood (before 5 years old for canrdidiasis, and before 15 years old for enamel hypoplasia). Oral candidiasis is recurrent all life long, could become resistant to azole antifungal after years of treatment, and be carcinogenic, leading to severe oral squamous cell carcinoma. Oral components of APS1 should be diagnosed and rigorously treated. Dental enamel hypoplasia and/or recurrent oral candidiasis in association with auto-immune diseases in a young child should prompt APS1 diagnosis.
[Mh] Termos MeSH primário: Doenças da Boca/diagnóstico
Poliendocrinopatias Autoimunes/diagnóstico
Odontopatias/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Candidíase Bucal/diagnóstico
Candidíase Bucal/genética
Criança
Pré-Escolar
Análise Mutacional de DNA
Hipoplasia do Esmalte Dentário/diagnóstico
Hipoplasia do Esmalte Dentário/genética
Diagnóstico Diferencial
Genes Recessivos/genética
Seres Humanos
Lactente
Doenças da Boca/genética
Fenótipo
Poliendocrinopatias Autoimunes/classificação
Poliendocrinopatias Autoimunes/genética
Odontopatias/genética
Fatores de Transcrição/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (APECED protein); 0 (Transcription Factors)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


  6 / 1709 MEDLINE  
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[PMID]:28605144
[Au] Autor:de Carvalho LM; Ngoumou G; Park JW; Ehmke N; Deigendesch N; Kitabayashi N; Melki I; Souza FFL; Tzschach A; Nogueira-Barbosa MH; Ferriani V; Louzada-Junior P; Marques W; Lourenço CM; Horn D; Kallinich T; Stenzel W; Hur S; Rice GI; Crow YJ
[Ad] Endereço:Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
[Ti] Título:Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy.
[So] Source:Arthritis Rheumatol;69(10):2081-2091, 2017 Oct.
[Is] ISSN:2326-5205
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To define the molecular basis of a multisystem phenotype with progressive musculoskeletal disease of the hands and feet, including camptodactyly, subluxation, and tendon rupture, reminiscent of Jaccoud's arthropathy. METHODS: We identified 2 families segregating an autosomal-dominant phenotype encompassing musculoskeletal disease and variable additional features, including psoriasis, dental abnormalities, cardiac valve involvement, glaucoma, and basal ganglia calcification. We measured the expression of interferon (IFN)-stimulated genes in the peripheral blood and skin, and undertook targeted Sanger sequencing of the IFIH1 gene encoding the cytosolic double-stranded RNA (dsRNA) sensor melanoma differentiation-associated protein 5 (MDA-5). We also assessed the functional consequences of IFIH1 gene variants using an in vitro IFNß reporter assay in HEK 293T cells. RESULTS: We recorded an up-regulation of type I IFN-induced gene transcripts in all 5 patients tested and identified a heterozygous gain-of-function mutation in IFIH1 in each family, resulting in different substitutions of the threonine residue at position 331 of MDA-5. Both of these variants were associated with increased IFNß expression in the absence of exogenous dsRNA ligand, consistent with constitutive activation of MDA-5. CONCLUSION: These cases highlight the significant musculoskeletal involvement that can be associated with mutations in MDA-5, and emphasize the value of testing for up-regulation of IFN signaling as a marker of the underlying molecular lesion. Our data indicate that both Singleton-Merten syndrome and neuroinflammation described in the context of MDA-5 gain-of-function constitute part of the same type I interferonopathy disease spectrum, and provide possible novel insight into the pathology of Jaccoud's arthropathy.
[Mh] Termos MeSH primário: Doenças da Aorta/genética
Doenças dos Gânglios da Base/genética
Calcinose/genética
Hipoplasia do Esmalte Dentário/genética
Glaucoma/genética
Doenças das Valvas Cardíacas/genética
Helicase IFIH1 Induzida por Interferon/genética
Metacarpo/anormalidades
Doenças Musculares/genética
Doenças Musculoesqueléticas/genética
Odontodisplasia/genética
Osteoporose/genética
Psoríase/genética
Calcificação Vascular/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Células HEK293
Heterozigoto
Seres Humanos
Meia-Idade
Mutação
Síndrome
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.6.1.- (IFIH1 protein, human); EC 3.6.4.13 (Interferon-Induced Helicase, IFIH1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE
[do] DOI:10.1002/art.40179


  7 / 1709 MEDLINE  
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[PMID]:28518210
[Au] Autor:Kalová K; Prichystalová R; Boberová K; Pavlusková A
[Ad] Endereço:Department of Archaeology and Museology, Faculty of Arts, Masaryk University, Brno, Arna Nováka 1, 602 00 Brno.
[Ti] Título:Regular graveyard in the stronghold versus settlement burials in the bailey. Comparison of Early Medieval populations from Pohansko (Czech Republic).
[So] Source:Anthropol Anz;74(2):155-171, 2017 Jul 01.
[Is] ISSN:0003-5548
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:ABSTRACT: The aim of the study is to identify possible differences in the prevalence of biological stress markers (cribra orbitalia, linear enammel hypoplasia), dental caries, activity markers (Schmorl's nodes) and markers of violence (traumatic lesions) in populations from a typical graveyard around the first church (9 -10 century AD) in the stronghold and from settlement burials in the southern bailey (second half of the 9 - beginning of the 10 century AD) of Slavs from Pohansko (Czech Republic). Cribra orbitalia and enamel hypoplasia did not markedly differ in either population. On the other hand, co-occurrence of both markers was statistically different and distinction in higher age categories could indicate diverse living conditions. Lower cariousness in the population from the southern bailey was identified. The nature of postcranial traumatic lesions in both populations indicates rather their accidental origin. However, a higher incidence of cranial injuries points to more violent activities in the population from Pohansko compared to Mikulcice. A high number of healed face injuries in males from the southern bailey could indicate higher intragroup violence in this population.
[Mh] Termos MeSH primário: Sepultamento/história
Cemitérios/história
[Mh] Termos MeSH secundário: Adolescente
Adulto
Doenças Ósseas/patologia
Criança
Pré-Escolar
República Tcheca/etnologia
Cárie Dentária/patologia
Hipoplasia do Esmalte Dentário/patologia
Feminino
História Medieval
Seres Humanos
Lactente
Recém-Nascido
Masculino
Meia-Idade
Doenças Orbitárias/patologia
Crânio/lesões
Crânio/patologia
Estresse Fisiológico
Adulto Jovem
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1127/anthranz/2017/0680


  8 / 1709 MEDLINE  
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[PMID]:28489117
[Au] Autor:Fragelli CMB; Souza JF; Bussaneli DG; Jeremias F; Santos-Pinto LD; Cordeiro RCL
[Ad] Endereço:Universidade do Estado de São Paulo - Unesp, Araraquara Dental School, Department of Orthodontics and Pediatric Dentistry, Araraquara, São Paulo, Brazil.
[Ti] Título:Survival of sealants in molars affected by molar-incisor hypomineralization: 18-month follow-up.
[So] Source:Braz Oral Res;31:e30, 2017 Apr 27.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to evaluate the clinical survival of sealants applied in first permanent molars (FPMs) affected by molar-incisor hypomineralization (MIH), at 18 months of follow-up. Forty-one first permanent molars were selected from 21 children, 6-8 years of age. MIH was classified by one calibrated examiner (kappa = 0.80) according to EAPD criteria. The inclusion criteria were fully erupted FPMs with MIH or sound FPMs (without MIH) for which sealant treatment was indicated. The FPMs were assigned to two groups: CG (control group) and HG (MIH group). Both groups were treated with sealant (FluroShield). Clinical follow-up was performed from baseline to 18 months to assess anatomical form, marginal adaptation, retention and presence of caries, according to criteria set by the United States Public Health Service-Modified, and was conducted by a blinded examiner (kappa = 0.80). The actuarial method was used to evaluate the survival of the sealants. The survival rates for the groups were compared using Fisher's exact test (α = 5%). The cumulative survival rates were 81% at 1 month, 68.8% at 6 months, 68.8% at 12 months, and 62.6% at 18 months for CG, and 88% at 1 month, 84% at 6 months, 76% at 12 months, and 72% at 18 months for HG. No significant difference was found between the groups. The sealants in molars affected by MIH presented a survival rate similar to the sealants in the control, suggesting that sealants may be an adequate approach for preventing carious lesions in MIH-affected molars.
[Mh] Termos MeSH primário: Bis-Fenol A-Glicidil Metacrilato/uso terapêutico
Cariostáticos/uso terapêutico
Hipoplasia do Esmalte Dentário/terapia
Falha de Restauração Dentária
Restauração Dentária Permanente/métodos
Fluoretos Tópicos/uso terapêutico
Selantes de Fossas e Fissuras/uso terapêutico
Poliuretanos/uso terapêutico
Fluoreto de Sódio/uso terapêutico
[Mh] Termos MeSH secundário: Criança
Cárie Dentária/prevenção & controle
Esmalte Dentário/efeitos dos fármacos
Dentição Permanente
Feminino
Seguimentos
Seres Humanos
Masculino
Estudos Prospectivos
Reprodutibilidade dos Testes
Medição de Risco
Análise de Sobrevida
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cariostatic Agents); 0 (Fluorides, Topical); 0 (Pit and Fissure Sealants); 0 (Polyurethanes); 0 (sodium fluoride topical preparation); 115628-44-9 (Fluoroshield); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate); 8ZYQ1474W7 (Sodium Fluoride)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE


  9 / 1709 MEDLINE  
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[PMID]:28407772
[Au] Autor:Gaillard T; Briolant S; Madamet M; Pradines B
[Ad] Endereço:Fédération des Laboratoires, Hôpital d'Instruction des Armées Desgenettes, Lyon, France.
[Ti] Título:The end of a dogma: the safety of doxycycline use in young children for malaria treatment.
[So] Source:Malar J;16(1):148, 2017 Apr 13.
[Is] ISSN:1475-2875
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Anti-malarial drug resistance to chloroquine and sulfadoxine-pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (ACT) in Southeast Asia highlights the need to identify new anti-malarial drugs. Doxycycline is recommended for malaria chemoprophylaxis for travel in endemic areas, or in combination with the use of quinine for malaria treatment when ACT is unavailable or when the treatment of severe malaria with artesunate fails. However, doxycycline is not used in young children under 8 years of age due to its contraindication due to the risk of yellow tooth discolouration and dental enamel hypoplasia. Doxycycline was developed after tetracycline and was labelled with the same side-effects as the earlier tetracyclines. However, recent studies report little or no effects of doxycycline on tooth staining or dental enamel hypoplasia in children under 8 years of age. In the United States, the Centers for Disease Control and Prevention have recommended the use of doxycycline for the treatment of acute and chronic Q fever and tick-borne rickettsial diseases in young children. It is time to rehabilitate doxycycline and to recommend it for malaria treatment in children under 8 years of age.
[Mh] Termos MeSH primário: Antimaláricos/efeitos adversos
Antimaláricos/uso terapêutico
Hipoplasia do Esmalte Dentário/induzido quimicamente
Doxiciclina/efeitos adversos
Doxiciclina/uso terapêutico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Malária/tratamento farmacológico
[Mh] Termos MeSH secundário: Quimioprevenção/efeitos adversos
Quimioprevenção/métodos
Criança
Pré-Escolar
Seres Humanos
Lactente
Recém-Nascido
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antimalarials); N12000U13O (Doxycycline)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1186/s12936-017-1797-9


  10 / 1709 MEDLINE  
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[PMID]:28322360
[Au] Autor:Bakkal M; Abbasoglu Z; Kargul B
[Ti] Título:The Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate on Molar-Incisor Hypomineralisation: A Pilot Study.
[So] Source:Oral Health Prev Dent;15(2):163-167, 2017.
[Is] ISSN:1602-1622
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) application on noncarious MIH (molar-incisor hypomineralisation) lesions using a DIAGNOdent device (KaVo), which measures laser fluorescence within the mineral structure of the tooth. MATERIALS AND METHODS: A total of 461 subjects age 7-12 (mean ±â€¯SD was 9.9 ±â€¯1.6) years were examined. Fifty- four children were diagnosed with MIH and divided into 2 groups. A total of 38 teeth met the inclusion criteria and were included in the study. Group 1 subjects (n = 15) used a paste containing 10% CPP-ACP, and group 2 subjects (n = 23) used a paste containing 10% CPP-ACP with 0.2% NaF (CPP-ACFP) for one month. RESULTS: After the application of the pastes for one month, significant decreases were found in the mean DIAGNOdent readings for both groups (CPP-ACP p = 0.0015 and CPP-ACFP p = 0.0001). However, the percentage decreases in both groups were not significantly different from each other (60.4% and 45.5% in CPP-ACP and CPP-ACFP groups, respectively). CONCLUSION: This pilot study shows that using CPP-ACP and CPP-ACFP had a positive effect in reducing hypomineralisation on enamel surfaces of MIH-diagnosed teeth for a one month period. It is important to diagnose molar-incisor hypomineralisation at an early stage to prevent excessive caries develeopment. Therefore, further clinical studies are necessary on the long-term application of these kinds of nanocomplexes.
[Mh] Termos MeSH primário: Caseínas/uso terapêutico
Hipoplasia do Esmalte Dentário/tratamento farmacológico
[Mh] Termos MeSH secundário: Criança
Feminino
Seres Humanos
Masculino
Projetos Piloto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caseins); 0 (casein phosphopeptide-amorphous calcium phosphate nanocomplex)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.3290/j.ohpd.a37928



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