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[PMID]:28183611
[Au] Autor:Epasinghe DJ; Kwan S; Chu D; Lei MM; Burrow MF; Yiu CKY
[Ad] Endereço:Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong, China.
[Ti] Título:Synergistic effects of proanthocyanidin, tri-calcium phosphate and fluoride on artificial root caries and dentine collagen.
[So] Source:Mater Sci Eng C Mater Biol Appl;73:293-299, 2017 Apr 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Proanthocyanidin has been shown to enhance dentine collagen stability and remineralization of artificial root caries. OBJECTIVES: To evaluate the effect of proanthocyanidin (PA) in combination with tri-calcium phosphate (TCP) and fluoride (F) on resistance to collagen degradation and remineralization of artificial caries lesions. METHODS: Demineralized root fragments (n=75) were randomly divided into five groups based on treatments: (i) 6.5% PA, (ii) TCP+F, (iii) TCP+F+6.5% PA, (iv) 1000ppm fluoride (Positive control) and (v) deionized water (control). Each specimen was subjected to pH cycling at 37 C for 8days. Lesion depth and mineral loss were evaluated using microradiography and confocal laser scanning microscopy. The type of crystal formation was determined by XRD spectra. To evaluate the stability of root caries lesions against collagenase challenge, highly purified type VII collagenase from Clostridium was added to obtain a remineralizing solution that contained 7.5U/mL collagenase and pH cycling was repeated. The different remineralizing solutions were collected after the pH cycling to assess the amount of hydroxyproline release. Collagen degradation depth and lesion depth were evaluated using transverse microradiography. Resistance to collagen degradation was determined using hydroxyproline assay. Data were analyzed using one-way ANOVA and Tukey multiple comparison tests. RESULTS: Results of one-way ANOVA showed that the test solutions had a significant effect on mineral loss (p<0.001) and lesion depth (p<0.001) of artificial root caries. The lowest lesion depth and mineral loss were observed in the TCP+F+PA (p<0.05) group. The XRD patterns showed hydroxyapatite formation on TCP+F-treated artificial caries lesions, which were not altered by the addition of PA. The addition of PA to TCP+F significantly reduced collagen degradation depth, when compared to TCP only group (p<0.001). Lesion depth was the lowest in the PA and TCP+F+PA groups following collagenase degradation (p<0.001). The addition of PA to TCP+F also decreased hydroxyproline release, when compared to TCP+F group (p<0.001). CONCLUSION: The addition of PA to TCP+F reduced collagen degradation, inhibited demineralization and enhanced remineralization.
[Mh] Termos MeSH primário: Fosfatos de Cálcio/uso terapêutico
Colágeno/química
Dentina/química
Fluoretos/uso terapêutico
Proantocianidinas/uso terapêutico
Cárie Radicular/tratamento farmacológico
[Mh] Termos MeSH secundário: Fosfatos de Cálcio/farmacologia
Colagenases/metabolismo
Cristalização
Sinergismo Farmacológico
Fluoretos/farmacologia
Seres Humanos
Concentração de Íons de Hidrogênio
Hidroxiprolina/análise
Microrradiografia
Microscopia Confocal
Minerais/análise
Proantocianidinas/farmacologia
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Phosphates); 0 (Minerals); 0 (Proanthocyanidins); 18206-61-6 (proanthocyanidin); 9007-34-5 (Collagen); EC 3.4.24.- (Collagenases); K4C08XP666 (tricalcium phosphate); Q80VPU408O (Fluorides); RMB44WO89X (Hydroxyproline)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170903
[Lr] Data última revisão:
170903
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


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[PMID]:27060450
[Au] Autor:Lee RC; Darling CL; Staninec M; Ragadio A; Fried D
[Ad] Endereço:Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, San Francisco, California, 94143-0758.
[Ti] Título:Activity assessment of root caries lesions with thermal and near-IR imaging methods.
[So] Source:J Biophotonics;10(3):433-445, 2017 Mar.
[Is] ISSN:1864-0648
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to evaluate thermal and near-infrared (NIR) reflectance imaging methods for the assessment of the activity of root caries lesions. In addition, changes in the lesion structure were monitored with polarization sensitive optical coherence tomography (PS-OCT). Artificial bovine and natural root caries lesions were imaged with PS-OCT, and their dehydration rate was measured with thermal and NIR cameras. The lesion activity of the natural root caries samples was also assessed by two clinicians by conventional means according to ICDAS II guidelines. The thickness of the highly mineralized transparent surface layer measured using PS-OCT increased and the area enclosed by the time-temperature curve, ΔQ, measured with thermal imaging decreased significantly with longer periods of remineralization in simulated dentin lesions, but the NIR reflectance intensity differences, ΔI, failed to show any significant relationship with the degree of remineralization. The PS-OCT algorithm for the automated assessment of remineralization successfully detected the highly mineralized surface layer on both natural and simulated lesions. Thermal imaging provided the most accurate diagnosis of root caries lesion activity. These results demonstrate that thermal imaging and PS-OCT may be ideally suited for the nondestructive root caries lesion activity during a clinical examination.
[Mh] Termos MeSH primário: Raios Infravermelhos
Cárie Radicular/diagnóstico por imagem
Tomografia de Coerência Óptica
[Mh] Termos MeSH secundário: Algoritmos
Animais
Área Sob a Curva
Bovinos
Dentina/diagnóstico por imagem
Dentina/patologia
Seres Humanos
Microrradiografia
Microscopia de Polarização
Modelos Anatômicos
Reconhecimento Automatizado de Padrão
Curva ROC
Cárie Radicular/patologia
Temperatura Ambiente
Remineralização Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160410
[St] Status:MEDLINE
[do] DOI:10.1002/jbio.201500333


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[PMID]:27957565
[Au] Autor:Zhang W; McGrath C; Lo EC
[Ti] Título:Effectiveness of DIAGNOdent in Detecting Root Caries Without Dental Scaling Among Community-dwelling Elderly.
[So] Source:Oral Health Prev Dent;14(6):555-561, 2016.
[Is] ISSN:1602-1622
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this clinical research was to analyze the effectiveness of DIAGNOdent in detecting root caries without dental scaling. MATERIALS AND METHODS: The status of 750 exposed, unfilled root surfaces was assessed by visual-tactile examination and DIAGNOdent before and after root scaling. The sensitivity and specificity of different cut-off DIAGNOdent values in diagnosing root caries with reference to visual-tactile criteria were evaluated on those root surfaces without visible plaque/calculus. The DIAGNOdent values from sound and carious root surfaces were compared using the nonparametric Mann-Whitney U-test. The level of statistical significance was set at 0.05. RESULTS: On root surfaces without plaque/calculus, significantly different (p < 0.05) DIAGNOdent readings were obtained from sound root surfaces (12.2 ± 11.1), active carious root surfaces (37.6 ± 31.7) and inactive carious root surfaces (20.9 ± 10.5) before scaling. On root surfaces with visible plaque, DIAGNOdent readings obtained from active carious root surfaces (29.6 ± 20.8) and inactive carious root surfaces (27.0 ± 7.2) were not statistically significantly different (p > 0.05). Furthermore, on root surfaces with visible calculus, all DIAGNOdent readings obtained from sound root surfaces were > 50, which might be misinterpreted as carious. After scaling, the DIAGNOdent readings obtained from sound root surfaces (8.1 ± 11.3), active carious root surfaces (37.9 ± 31.9) and inactive carious root surfaces (24.9 ± 11.5) presented significant differences (p < 0.05). A cut-off value between 10 and 15 yielded the highest combined sensitivity and specificity in detecting root caries on root surfaces without visible plaque/calculus before scaling, but the combined sensitivity and specificity are both around 70%. CONCLUSION: These findings suggest that on exposed, unfilled root surfaces without visible plaque/calculus, DIAGNOdent can be used as an adjunct to the visual-tactile criteria in detecting root-surface status without pre-treatment by dental scaling.
[Mh] Termos MeSH primário: Cárie Radicular/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Raspagem Dentária
Testes Diagnósticos de Rotina/métodos
Feminino
Seres Humanos
Masculino
Meia-Idade
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE
[do] DOI:10.3290/j.ohpd.a37140


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[PMID]:27514155
[Au] Autor:Tanner AC; Kressirer CA; Faller LL
[Ti] Título:Understanding Caries From the Oral Microbiome Perspective.
[So] Source:J Calif Dent Assoc;44(7):437-46, 2016 Jul.
[Is] ISSN:1043-2256
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dental caries is a major disease of the oral cavity with profound clinical significance. Caries results from a transition of a healthy oral microbiome into an acidogenic community of decreased microbial diversity in response to excessive dietary sugar intake. Microbiological cultivation, molecular identification, gene expression and metabolomic analyses show the importance of the entire microbial community in understanding the role of the microbiome in the pathology of caries.
[Mh] Termos MeSH primário: Cárie Dentária/microbiologia
Microbiota/fisiologia
Boca/microbiologia
[Mh] Termos MeSH secundário: Ácidos
Biofilmes
Esmalte Dentário/microbiologia
Dentina/microbiologia
Seres Humanos
Concentração de Íons de Hidrogênio
Interações Microbianas/fisiologia
Cárie Radicular/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Acids)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160812
[Lr] Data última revisão:
160812
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE


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[PMID]:27458979
[Au] Autor:Takahashi N; Nyvad B
[Ad] Endereço:Division of Oral Ecology and Biochemistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
[Ti] Título:Ecological Hypothesis of Dentin and Root Caries.
[So] Source:Caries Res;50(4):422-31, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Recent advances regarding the caries process indicate that ecological phenomena induced by bacterial acid production tilt the de- and remineralization balance of the dental hard tissues towards demineralization through bacterial acid-induced adaptation and selection within the microbiota - from the dynamic stability stage to the aciduric stage via the acidogenic stage [Takahashi and Nyvad, 2008]. Dentin and root caries can also be partly explained by this hypothesis; however, the fact that these tissues contain a considerable amount of organic material suggests that protein degradation is involved in caries formation. In this review, we compiled relevant histological, biochemical, and microbiological information about dentin/root caries and refined the hypothesis by adding degradation of the organic matrix (the proteolytic stage) to the abovementioned stages. Bacterial acidification not only induces demineralization and exposure of the organic matrix in dentin/root surfaces but also activation of dentin-embedded and salivary matrix metalloproteinases and cathepsins. These phenomena initiate degradation of the demineralized organic matrix in dentin/root surfaces. While a bacterial involvement has never been confirmed in the initial degradation of organic material, the detection of proteolytic/amino acid-degrading bacteria and bacterial metabolites in dentin and root caries suggests a bacterial digestion and metabolism of partly degraded matrix. Moreover, bacterial metabolites might induce pulpitis as an inflammatory/immunomodulatory factor. Root and dentin surfaces are always at risk of becoming demineralized in the oral cavity, and exposed organic materials can be degraded by host-derived proteases contained in saliva and dentin itself. New approaches to the prevention and treatment of root/dentin caries are required.
[Mh] Termos MeSH primário: Bactérias/metabolismo
Cárie Dentária/microbiologia
Dentina/microbiologia
Raiz Dentária/microbiologia
[Mh] Termos MeSH secundário: Catepsinas/metabolismo
Colágeno/metabolismo
Cárie Dentária/patologia
Dentina/patologia
Seres Humanos
Concentração de Íons de Hidrogênio
Metaloproteinases da Matriz/metabolismo
Cárie Radicular/microbiologia
Cárie Radicular/patologia
Saliva/enzimologia
Raiz Dentária/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
9007-34-5 (Collagen); EC 3.4.- (Cathepsins); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE
[do] DOI:10.1159/000447309


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[PMID]:27253146
[Au] Autor:Cruz Gonzalez AC; Marín Zuluaga DJ
[Ad] Endereço:Universidad Nacional de Colombia, Universidad Nacional de Colombia, Facultad de Odontología, Bogotá , Colombia, Universidad Nacional de Colombia, Facultad de Odontología, Posgrado de Rehabilitación Oral, Bogotá, Colombia.
[Ti] Título:Clinical outcome of root caries restorations using ART and rotary techniques in institutionalized elders.
[So] Source:Braz Oral Res;30(1), 2016 May 31.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to compare the clinical performance of root caries restorations after a six-month period using two methods, a conventional technique with rotary instruments and an atraumatic restorative technique (ART), in an institutionalized elderly population in the city of Bogotá, Colombia. Root caries represents a multifactorial, progressive, chronic lesion with softened, irregular and darkened tissue involving the radicular surface; it is highly prevalent in the elderly, especially in those who are physically or cognitively impaired. A quasi-experimental, double-blind, longitudinal study was carried out after cluster randomization of the sample. Two different experienced dentists, previously trained, performed the restorations using each technique. After six months, two new investigators performed a blind evaluation of the condition of the restorations. The results showed a significantly higher rate of success (92.9%) using the conventional technique (p < 0.03). However, we concluded that ART may have been the preferred technique in the study population because 81% of those restorations survived or were successful during the observation period.
[Mh] Termos MeSH primário: Tratamento Dentário Restaurador sem Trauma/métodos
Instrumentos Odontológicos
Restauração Dentária Permanente/instrumentação
Cárie Radicular/terapia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Assistência Odontológica para Idosos
Falha de Restauração Dentária
Restauração Dentária Permanente/métodos
Método Duplo-Cego
Feminino
Cimentos de Ionômeros de Vidro/uso terapêutico
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
Casas de Saúde
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Glass Ionomer Cements)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE


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[PMID]:27164727
[Au] Autor:Curtis D
[Ti] Título:Are we doing enough for the geriatric patient?
[So] Source:Int J Prosthodont;29(2):111-2, 2016 Mar-Apr.
[Is] ISSN:0893-2174
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cárie Dentária/prevenção & controle
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Cariostáticos/uso terapêutico
Efeitos Psicossociais da Doença
Cárie Dentária/economia
Cárie Dentária/etiologia
Comportamento Alimentar
Fluoretos Tópicos/uso terapêutico
Saúde Global
Seres Humanos
Medição de Risco
Cárie Radicular/economia
Cárie Radicular/etiologia
Cárie Radicular/prevenção & controle
Classe Social
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Cariostatic Agents); 0 (Fluorides, Topical)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE


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[PMID]:27160516
[Au] Autor:Ritter AV; Preisser JS; Puranik CP; Chung Y; Bader JD; Shugars DA; Makhija S; Vollmer WM
[Ad] Endereço:School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA.
[Ti] Título:A Predictive Model for Root Caries Incidence.
[So] Source:Caries Res;50(3):271-8, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This study aimed to find the set of risk indicators best able to predict root caries (RC) incidence in caries-active adults utilizing data from the Xylitol for Adult Caries Trial (X-ACT). Five logistic regression models were compared with respect to their predictive performance for incident RC using data from placebo-control participants with exposed root surfaces at baseline and from two study centers with ancillary data collection (n = 155). Prediction performance was assessed from baseline variables and after including ancillary variables [smoking, diet, use of removable partial dentures (RPD), toothbrush use, income, education, and dental insurance]. A sensitivity analysis added treatment to the models for both the control and treatment participants (n = 301) to predict RC for the control participants. Forty-nine percent of the control participants had incident RC. The model including the number of follow-up years at risk, the number of root surfaces at risk, RC index, gender, race, age, and smoking resulted in the best prediction performance, having the highest AUC and lowest Brier score. The sensitivity analysis supported the primary analysis and gave slightly better performance summary measures. The set of risk indicators best able to predict RC incidence included an increased number of root surfaces at risk and increased RC index at baseline, followed by white race and nonsmoking, which were strong nonsignificant predictors. Gender, age, and increased number of follow-up years at risk, while included in the model, were also not statistically significant. The inclusion of health, diet, RPD use, toothbrush use, income, education, and dental insurance variables did not improve the prediction performance.
[Mh] Termos MeSH primário: Cárie Dentária/epidemiologia
Cárie Radicular/epidemiologia
Edulcorantes/administração & dosagem
Xilitol/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Cárie Dentária/etiologia
Cárie Dentária/prevenção & controle
Diagnóstico por Imagem
Inquéritos sobre Dietas/estatística & dados numéricos
Método Duplo-Cego
Feminino
Seres Humanos
Incidência
Modelos Logísticos
Masculino
Meia-Idade
Modelos Teóricos
Estudos Multicêntricos como Assunto
Saúde Bucal/estatística & dados numéricos
Estudos Prospectivos
Ensaios Clínicos Controlados Aleatórios como Assunto
Fatores de Risco
Cárie Radicular/etiologia
Cárie Radicular/prevenção & controle
Fatores Sexuais
Escovação Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Sweetening Agents); VCQ006KQ1E (Xylitol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160511
[St] Status:MEDLINE
[do] DOI:10.1159/000445445


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[PMID]:27101401
[Au] Autor:Ekstrand KR
[Ad] Endereço:Department of Odontology, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:High Fluoride Dentifrices for Elderly and Vulnerable Adults: Does It Work and if So, Then Why?
[So] Source:Caries Res;50 Suppl 1:15-21, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The primary aim of this work is to present the available evidence that toothpastes containing >1,500 ppm fluoride (2,500-2,800 and 5,000 ppm F) provide an additional caries preventive effect on root caries lesions in elderly patients compared to traditional dentifrices (1,000-1,450 ppm F). The secondary aim of this paper is to discuss why high fluoride dentifrices in general should perform better than traditional F-containing toothpaste. When examining the few studies that have considered the preventive benefits of high fluoride products on root caries the relative risk appears to be around 0.5, and the risk can thus be halved by exchanging traditional F-containing toothpaste for toothpaste containing 5,000 ppm F. There is reasonable evidence that high fluoride dentifrices significantly increase the fluoride concentration in saliva during the day and the fluoride concentration in plaque compared to traditional F toothpaste. Furthermore, the use of toothpaste with 5,000 ppm F significantly reduces the amount of plaque accumulated, decreases the number of mutans streptococci and lactobacilli and possibly promotes calcium fluoride deposits to a higher degree than after the use of traditional F-containing toothpaste.
[Mh] Termos MeSH primário: Cárie Dentária/terapia
Fluoretos/uso terapêutico
Cárie Radicular/terapia
Cremes Dentais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Cárie Dentária/prevenção & controle
Placa Dentária/terapia
Feminino
Fluoretos/análise
Fluoretos/farmacologia
Seres Humanos
Cárie Radicular/prevenção & controle
Saliva/efeitos dos fármacos
Streptococcus mutans/efeitos dos fármacos
Cremes Dentais/química
Cremes Dentais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Toothpastes); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1159/000443021


  10 / 740 MEDLINE  
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[PMID]:27101002
[Au] Autor:Twetman S; Keller MK
[Ad] Endereço:Department of Odontology, School of Dentistry, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:Fluoride Rinses, Gels and Foams: An Update of Controlled Clinical Trials.
[So] Source:Caries Res;50 Suppl 1:38-44, 2016.
[Is] ISSN:1421-976X
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:AIM: The aim of this conference paper was to systematically review the quality of evidence and summarize the findings of clinical trials published after 2002 using fluoride mouth rinses, fluoride gels or foams for the prevention of dental caries. METHODS: Relevant papers were selected after an electronic search for literature published in English between 2003 and 2014. The included papers were assessed for their risk of bias and the results were narratively synthesized due to study heterogeneity. The quality of evidence was expressed according to GRADE. RESULTS: A total of 19 papers were included (6 on fluoride mouth rinse, 10 on fluoride gel and 3 on fluoride foam); 6 had a low risk of bias while 2 had a moderate risk. All fluoride measures appeared to be beneficial in preventing crown caries and reversing root caries, but the quality of evidence was graded as low for fluoride mouth rinse, moderate for fluoride gel and very low for acidulated fluoride foam. No conclusions could be drawn on the cost-effectiveness. CONCLUSIONS: This review, covering the recent decade, has further substantiated the evidence for a caries-preventive effect of fluoride mouth rinse, fluoride gel and foam, previously established in systematic reviews. The lack of clinical trials free from bias is, however, still a concern, especially for fluoride mouth rinses and fluoride foam. There is also a scientific knowledge gap on the benefit and optimal use of these fluoride supplements in combination with daily tooth brushing with fluoride toothpaste.
[Mh] Termos MeSH primário: Cárie Dentária/terapia
Fluoretos Tópicos/administração & dosagem
Fluoretos/uso terapêutico
Antissépticos Bucais/administração & dosagem
Fosfatos/uso terapêutico
Cárie Radicular/terapia
[Mh] Termos MeSH secundário: Envelhecimento
Viés
Ensaios Clínicos Controlados como Assunto
Análise Custo-Benefício
Cárie Dentária/prevenção & controle
Odontologia Baseada em Evidências/estatística & dados numéricos
Fluoretos Tópicos/farmacologia
Géis
Seres Humanos
Antissépticos Bucais/farmacologia
Cárie Radicular/prevenção & controle
Dente/efeitos dos fármacos
Escovação Dentária
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Fluorides, Topical); 0 (Gels); 0 (Mouthwashes); 0 (Phosphates); 15181-43-8 (fluorophosphate); Q80VPU408O (Fluorides)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1159/000439180



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