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[PMID]:29446284
[Au] Autor:Kudaeva IV; Dyakovich OA; Beygel EA; Masnavieva LB; Naumova OV; Budarina LA
[Ti] Título:[Clinical, biochemical and allergological indices characterizing occupational diseases of the bronchial and pulmonary system in employees at aluminium production].
[So] Source:Gig Sanit;95(12):1142-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:There are many harmful factors that possess a damaging impact on the body of employees at aluminum production. It leads to the development of bronchial asthma (BA), chronic nonobstructive bronchitis (CNB) and chronic obstructive pulmonary disease (COPD). The pathogenesis of these disorders, as well as sensitizing effect offluorine in the aluminum production is not fully understood. The purpose of this work was to study the characteristics of laboratory indices in patients with occupational diseases of the respiratory system. In workers of aluminum production with the diagnosis of occupational diseases of respiratory system (15 patients with a diagnosis of asthma, 30 CNB cases, 20 COPD patients) we evaluated the content of total protein, total cholesterol, high density lipoprotein cholesterol (HDLC), total calcium, phosphorus, ceruloplasmin, hematological indices and performed emigration of leukocytes braking test (TTEEL). Clinical and biochemical profile ofpersons with occupational asthma was characterized by a low level of total calcium and ceruloplasmin, a high concentration of phosphorus in the blood serum and inhibition of leukocyte emigration in the test with sodium fluoride. For aluminum production CNB workers characteristic active proatherogenic process was pronounced by a decrease in the HDLC level and an increase in atherogenic index; higher hematocrit value and concentration of erythrocytes, and more than 50% of cases of sensitization to the presence of sodium fluoride. COPD cases had occupational lower average concentration of hemoglobin in the erythrocyte, total protein in serum, as well as polymorphic variant response to sodium fluoride in the form of a depression and activation of leucocytes emigration.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar
Alumínio
Asma Ocupacional
Indústria Química
Doença Pulmonar Obstrutiva Crônica
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/análise
Poluentes Ocupacionais do Ar/toxicidade
Alumínio/análise
Alumínio/toxicidade
Asma Ocupacional/sangue
Asma Ocupacional/diagnóstico
Asma Ocupacional/epidemiologia
Biomarcadores/análise
Indústria Química/métodos
Indústria Química/normas
Seres Humanos
Masculino
Meia-Idade
Exposição Ocupacional/efeitos adversos
Exposição Ocupacional/análise
Exposição Ocupacional/prevenção & controle
Saúde do Trabalhador/estatística & dados numéricos
Doença Pulmonar Obstrutiva Crônica/sangue
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Doença Pulmonar Obstrutiva Crônica/etiologia
Hipersensibilidade Respiratória/sangue
Hipersensibilidade Respiratória/induzido quimicamente
Hipersensibilidade Respiratória/diagnóstico
Sibéria/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Biomarkers); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180216
[St] Status:MEDLINE


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[PMID]:28459315
[Au] Autor:Balmes JR
[Ad] Endereço:1 Division of Occupational and Environmental Medicine University of California, San Francisco San Francisco, California and.
[Ti] Título:AJRCCM: 100-Year Anniversary. Clearing the Air: Indoors, Outdoors, and At Work.
[So] Source:Am J Respir Crit Care Med;195(9):1100-1103, 2017 May 01.
[Is] ISSN:1535-4970
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Poluição do Ar em Ambientes Fechados/prevenção & controle
Pneumopatias/prevenção & controle
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/prevenção & controle
Publicações Periódicas como Assunto/história
Pneumologia/história
Poluição por Fumaça de Tabaco/prevenção & controle
[Mh] Termos MeSH secundário: Poluição do Ar/prevenção & controle
Aniversários e Eventos Especiais
Asma Ocupacional/prevenção & controle
História do Século XX
História do Século XXI
Seres Humanos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1164/rccm.201701-0152ED


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[PMID]:28533885
[Au] Autor:Omrane A; Kreim A; Henchi MA; Kammoun S; Bessadi L; Amri C; Khalfallh T; Bouzgarrou L
[Ad] Endereço:Département de Médecine de Travail et d'Ergonomie, Faculté de Médecine de Monastir, Monastir, Tunisie.
[Ti] Título:[Occupational asthma compensation in the Tunisian Center: cross-sectional study over a period of eight years].
[Ti] Título:Asthme professionnel indemnisé dans le centre tunisien: étude ransversale sur huit ans..
[So] Source:Pan Afr Med J;26:164, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Our study aimed to highlight the epidemiological profile of patients compensated for occupational asthma in the Tunisian Center, to identify their professional characteristics and to determine compensation practices for this occupational disease. METHODS: We conducted an exhaustive retrospective study over a period of eight years. This case study included workers with occupational asthma diagnosed and compensated in the Tunisian Center by the only two medical commissions empowered to set rates for permanent partial disability caused by either a work-related injury or an occupational diseases in the seven central governorates. RESULTS: A total of 129 workers, with average age of 40.6 ± 7.75 years were compensated for occupational asthma during the study period. Sex ratio was 0.66. The most incriminated etiologic agents were vegetable dust pollution in the textile industry (75.2%), wood dust, flour and isocyanates. Nonspecific bronchial hyperreactivity was found in 38% of cases, a high rate of IgE in 14% of cases and positive skin prick test in 10.9% of cases. The average rate of permanent partial disability was 25.6 ± 14.2%. On the basis of the analytical study, this rate was related to patient's age and to the medical commission which had set this rate. CONCLUSION: This study of workers compensated for occupational asthma provides relevant data about epidemiological and clinical features of diagnosed patients and committee practices in particular, in term of application of the voluntary indicative scale, but it does not allow an assessment of the prevalence of this pathology which is often underestimated.
[Mh] Termos MeSH primário: Asma Ocupacional/epidemiologia
Exposição Ocupacional/efeitos adversos
Indenização aos Trabalhadores/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Asma Ocupacional/economia
Hiper-Reatividade Brônquica/epidemiologia
Estudos Transversais
Avaliação da Deficiência
Feminino
Seres Humanos
Masculino
Meia-Idade
Exposição Ocupacional/economia
Estudos Retrospectivos
Testes Cutâneos
Tunísia/epidemiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.26.164.11486


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[PMID]:28383629
[Au] Autor:Ragusa F; Fallahi P
[Ad] Endereço:Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa.
[Ti] Título:IP-10 in occupational asthma: review of the literature and case-control study.
[So] Source:Clin Ter;168(2):e151-e157, 2017 Mar-Apr.
[Is] ISSN:1972-6007
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: T-helper (Th)2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1-related chemokine, interferon (IFN)-γ-induced protein 10 (IP-10)/chemokine (C-X-C motif) ligand (CXCL)10, was the predominant chemokine measured during human allergic pulmonary late-phase reaction. Viral infection and allergens can exacerbate asthma by inducing the accumulation of these chemokines and inflammatory cells in the airway. Short-acting ß2-adrenoreceptor agonists, budesonide and formoterol (all important relievers in asthma exacerbation), such as vitamin D3, vitamin C, have been shown to inhibit airway cells inflammatory responses by modulating these chemokines. Furthemore it has been suggested that Th1-related IP-10 and monokine induced by IFN-γ (MIG)/CXCL9 may be useful inflammatory markers of asthma exacerbation. PATIENTS AND METHODS: In this study we have evaluated serum levels of the Th1-related CXC chemokine IP-10, in 8 patients with occupational asthma (OA) during exacerbation due to occupational exposure, and after 2-3 months, when patients were in stable conditions, in comparison with 8 age and gender matched healthy subjects. RESULTS: A significant increase in the serum levels of IP-10 were found in OA patients with an acute exacerbation in contrast to healthy controls (p<0.01), and in comparison with same OA patients after 2-3 months, when they were without any respiratory symptoms or disorders. CONCLUSIONS: These results suggest that the Th1-related CXC chemokines IP-10 is an useful inflammatory marker of OA exacerbation. However, other studies in larger number of patients are needed.
[Mh] Termos MeSH primário: Asma Ocupacional/imunologia
Quimiocina CXCL10/sangue
Citocinas/sangue
[Mh] Termos MeSH secundário: Adulto
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (CXCL10 protein, human); 0 (Chemokine CXCL10); 0 (Cytokines)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.7417/CT.2017.1998


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[PMID]:28314756
[Au] Autor:Jonaid BS; Rooyackers J; Stigter E; Portengen L; Krop E; Heederik D
[Ad] Endereço:Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
[Ti] Título:Predicting occupational asthma and rhinitis in bakery workers referred for clinical evaluation.
[So] Source:Occup Environ Med;74(8):564-572, 2017 Aug.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Occupational allergic diseases are a major problem in some workplaces like in the baking industry. Diagnostic rules have been used in surveillance but not yet in the occupational respiratory clinic. OBJECTIVE: To develop diagnostic models predicting baker's asthma and rhinitis among bakery workers at high risk of sensitisation to bakery allergens referred to a specialised clinic. METHODS: As part of a medical surveillance programme, clinical evaluation was performed on 436 referred Dutch bakery workers at high risk for sensitisation to bakery allergens. Multivariable logistic regression analyses were developed to identify the predictors of onset of baker's asthma and rhinitis using a self-administered questionnaire and compared using a structured medical history. Performance of models was assessed by discrimination (area under the receiver operating characteristics curve) and calibration (Hosmer-Lemeshow test). Internal validity of the models was assessed by a bootstrapping procedure. RESULTS: The prediction models included the predictors of work-related upper and lower respiratory symptoms, the presence of allergy and allergic symptoms, use of medication (last year), type of job, type of shift and working years with symptoms (≥10 years). The developed models derived from both self-administered questionnaire and the medical history showed a relatively good discrimination and calibration. The internal validity showed that the models developed had satisfactory discrimination. To improve calibrations of models, shrinkage factors were applied to model coefficients. CONCLUSION: The probability of allergic asthma and rhinitis in referred bakers could be estimated by diagnostic models based on both a self-administered questionnaire and by taking a structured medical history.
[Mh] Termos MeSH primário: Asma Ocupacional/diagnóstico
Rinite Alérgica/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Asma Ocupacional/epidemiologia
Feminino
Farinha/efeitos adversos
Indústria Alimentícia
Seres Humanos
Imunoglobulina E/sangue
Modelos Logísticos
Masculino
Anamnese
Meia-Idade
Países Baixos/epidemiologia
Doenças Profissionais/diagnóstico
Doenças Profissionais/epidemiologia
Exposição Ocupacional/efeitos adversos
Rinite Alérgica/epidemiologia
Fatores de Risco
Sensibilidade e Especificidade
Espirometria
Inquéritos e Questionários
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170319
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103934


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[PMID]:28270447
[Au] Autor:Hu C; Cruz MJ; Ojanguren I; de Homdedeu M; Gonzalez-Barcala FJ; Munoz X
[Ad] Endereço:Pulmonology, Hospital General Universitario Morales Meseguer, Murcia, Spain.
[Ti] Título:Specific inhalation challenge: the relationship between response, clinical variables and lung function.
[So] Source:Occup Environ Med;74(8):586-591, 2017 Aug.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The specific inhalation challenge (SIC) is considered the gold standard for the diagnosis of occupational asthma (OA). However, its use is not standardised, and the intensity of exposure is regulated empirically. The aim of this study was to identify clinical variables and/or pulmonary function variables able to predict the scale of patients' response to SIC. MATERIAL AND METHODS: All patients who underwent SIC at our centre between 2005 and 2013 were studied. Anthropometric characteristics, atopic status, type of causal agent, latency times, pulmonary function tests and SIC results were analysed. RESULTS: Two hundred and one patients (51% men) were assessed, of whom 86 (43%) had positive SIC. In the patients with positive results, 29 (34%) were exposed to high molecular weight (HMW) agents and 57 (64%) to low molecular weight (LMW) agents. Patients with a positive SIC exposed to HMW agents had a higher fall in FEV after SIC compared with those exposed to LMW agents (p=0.036). The type of asthmatic reaction after SIC also differed between the groups (p=0.020). The logistic regression analysis showed that patients with a higher PC before SIC were less likely to have severe decreases in FEV1 after SIC after adjusting for potential confounders (OR=0.771, 95% CI 0.618 to 0.961, p=0.021). CONCLUSIONS: The scale of the response to SIC is influenced mainly by the degree of bronchial hyper-responsiveness, regardless of whether the causative agent is HMW or LMW, or whether the response is early or late.
[Mh] Termos MeSH primário: Asma Ocupacional/diagnóstico
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Administração por Inalação
Adulto
Alérgenos/administração & dosagem
Antropometria
Feminino
Volume Expiratório Forçado
Seres Humanos
Modelos Logísticos
Masculino
Meia-Idade
Doenças Profissionais/diagnóstico
Testes de Função Respiratória
Espanha
Espirometria
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-103806


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[PMID]:28211347
[Au] Autor:Poussel M; Penven E; Essari LA; Chabot F; Barbaud A; Paris C
[Ad] Endereço:Department of Pulmonary Function Testing and Exercise Physiology, CHRU Nancy, Nancy, France.
[Ti] Título:Occupational Asthma to Detergent Protease Associated With a Late-Phase Neutrophilic Cutaneous Response.
[So] Source:J Investig Allergol Clin Immunol;27(1):60-62, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Amilases/efeitos adversos
Asma Ocupacional/induzido quimicamente
Detergentes/efeitos adversos
Pulmão/efeitos dos fármacos
Neutrófilos/efeitos dos fármacos
Exposição Ocupacional/efeitos adversos
Saúde do Trabalhador
Peptídeo Hidrolases/efeitos adversos
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amilases/imunologia
Asma Ocupacional/diagnóstico
Asma Ocupacional/imunologia
Asma Ocupacional/fisiopatologia
Testes de Provocação Brônquica
Broncoconstrição
Feminino
Volume Expiratório Forçado
Seres Humanos
Imunoglobulina E/imunologia
Testes Intradérmicos
Pulmão/imunologia
Pulmão/fisiopatologia
Meia-Idade
Neutrófilos/imunologia
Peptídeo Hidrolases/imunologia
Pele/imunologia
Capacidade Vital
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Detergents); 37341-29-0 (Immunoglobulin E); EC 3.2.1.- (Amylases); EC 3.4.- (Peptide Hydrolases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0115


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[PMID]:28181152
[Au] Autor:Cleven KL; Webber MP; Zeig-Owens R; Hena KM; Prezant DJ
[Ad] Endereço:Department of Medicine, Division of Pulmonary Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY, 10467, USA.
[Ti] Título:Airway Disease in Rescue/Recovery Workers: Recent Findings from the World Trade Center Collapse.
[So] Source:Curr Allergy Asthma Rep;17(1):5, 2017 Jan.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Our goal is to summarize the airway disease literature since September 11, 2001 (9/11), focusing on studies published since 2011 in World Trade Center-exposed rescue/recovery workers. RECENT FINDINGS: Since 2011, studies have confirmed relationships between initial World Trade Center exposure intensity, severity of symptoms, airway disease diagnoses, and biomarkers of disease progression. Studies continue to document ongoing morbidity in rescue/recovery workers over 10 years after 9/11. Future research should further identify correlates of symptom persistence and new airway disease diagnoses. The unique characteristics of the airway diseases in this population warrant ongoing monitoring and treatment.
[Mh] Termos MeSH primário: Doenças Profissionais/diagnóstico
Doenças Profissionais/etiologia
Trabalho de Resgate
Transtornos Respiratórios/diagnóstico
Transtornos Respiratórios/etiologia
Ataques Terroristas de 11 de Setembro
[Mh] Termos MeSH secundário: Asma Ocupacional/diagnóstico
Asma Ocupacional/etiologia
Seres Humanos
Exposição por Inalação/efeitos adversos
Exposição por Inalação/estatística & dados numéricos
Exposição Ocupacional
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170210
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-017-0670-9


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[PMID]:28177949
[Au] Autor:Seed MJ; Agius RM
[Ad] Endereço:Centre for Occupational and Environmental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
[Ti] Título:Progress with Structure-Activity Relationship modelling of occupational chemical respiratory sensitizers.
[So] Source:Curr Opin Allergy Clin Immunol;17(2):64-71, 2017 Apr.
[Is] ISSN:1473-6322
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: This appraises currently available computer-based ('in silico') models relating the molecular structure of low molecular weight compounds to their respiratory sensitization hazard. The present review places focus on the two main applications of such structure--activity relationship (SAR) models: hypotheses on disease mechanisms and toxicological prediction. RECENT FINDINGS: Analyses of the chemical structures of low molecular weight organic compounds known to have caused occupational asthma has led to the development of mechanistic alerts usually based on electrophilic reaction chemistry and protein cross-linking potential. Protein cross-linking potential has also been found to be a consistent feature of chemicals that have caused human cases of hypersensitivity pneumonitis. Stepwise iteration of quantitative SAR (QSAR) modelling has shown appreciable improvements in predictivity for occupational asthma hazard and useful prospects for practical application. A good case has also been made for the potential use of structural alert-based mechanistic SARs in predictive toxicology. SUMMARY: Further understanding of the molecular interactions between chemical respiratory sensitizers and components of human proteins have been obtained from in-vitro and in-silico techniques. There have been developments in both qualitative (mechanistic) SARs and QSARs, which offer potential for use in a predictive algorithm for the toxicological screening of industrial chemicals for respiratory sensitization potential.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/imunologia
Alérgenos/imunologia
Alveolite Alérgica Extrínseca/diagnóstico
Asma Ocupacional/diagnóstico
Simulação por Computador
Compostos Orgânicos/imunologia
Relação Quantitativa Estrutura-Atividade
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/efeitos adversos
Animais
Seres Humanos
Programas de Rastreamento
Prognóstico
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Allergens); 0 (Organic Chemicals)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE
[do] DOI:10.1097/ACI.0000000000000355


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[PMID]:28091866
[Au] Autor:Pralong JA; Cartier A
[Ad] Endereço:Institute for Work and Health, Route de la Corniche 2, 1066, Epalinges, Switzerland.
[Ti] Título:Review of Diagnostic Challenges in Occupational Asthma.
[So] Source:Curr Allergy Asthma Rep;17(1):1, 2017 Jan.
[Is] ISSN:1534-6315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE OF REVIEW: Occupational asthma (OA) is one of the most frequent occupational diseases and its diagnosis is often difficult. This review summarizes its current diagnostic challenges. RECENT FINDINGS: OA is associated with significant health and socio-economic burden. It is underdiagnosed and physicians need to adopt a stepwise approach to confirm the diagnosis. Although early removal from exposure to the offending agent is associated with a better prognosis, physicians should try to confirm the diagnosis of work-related asthma before taking a worker off work. A proper occupational and medical history is very important but is not enough to make the diagnosis of OA. Objective evidence of work-related asthma is required and this represents a serious challenge to most physicians. Measurement of non-specific bronchial responsiveness (NSBR) and spirometry may confirm the diagnosis of asthma but do not confirm the diagnosis of OA. Serial monitoring of peak expiratory flows (PEF), NSBR, and airway inflammation at and off work may confirm the diagnosis of OA but are often difficult to perform. Confirming sensitization by skin prick tests or specific IgE may help to support the diagnosis of OA. Specific inhalation challenges (SIC) in the lab or at work are considered the reference standard but are of limited access. Medical surveillance programs along with primary prevention (reducing exposure) may help to reduce the burden of OA, but the ideal program has yet to be defined. The diagnostic workup of OA remains a challenge and needs a rigorous stepwise evaluation.
[Mh] Termos MeSH primário: Asma Ocupacional/diagnóstico
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Seres Humanos
Testes Cutâneos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE
[do] DOI:10.1007/s11882-017-0676-3



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