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[PMID]:28682949
[Au] Autor:Mumphansha H; Nickerson JW; Attaran A; Overton S; Curtis S; Mayer P; Bould MD
[Ad] Endereço:From the *Department of Anaesthesia, University Teaching Hospital, Lusaka, Zambia; †Bruyère Research Institute, Ottawa, Ontario, Canada; ‡Faculty of Law, University of Ottawa, Ottawa, Ontario, Canada; §John L. Holmes Mass Spectrometry Facility, Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada; and ‖Anesthesiology and Pain Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.
[Ti] Título:An Analysis of Substandard Propofol Detected in Use in Zambian Anesthesia.
[So] Source:Anesth Analg;125(2):616-619, 2017 Aug.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In early 2015, clinicians throughout Zambia noted a range of unpredictable adverse events after the administration of propofol, including urticaria, bronchospasm, profound hypotension, and most predictably an inadequate depth of anesthesia. Suspecting that the propofol itself may have been substandard, samples were procured and sent for testing. METHODS: Three vials from 2 different batches were analyzed using gas chromatography-mass spectrometry methods at the John L. Holmes Mass Spectrometry Facility. RESULTS: Laboratory gas chromatography-mass spectrometry analysis determined that, although all vials contained propofol, its concentration differed between samples and in all cases was well below the stated quantity. Two vials from 1 batch contained only 44% ± 11% and 54% ± 12% of the stated quantity, whereas the third vial from a second batch contained only 57% ± 9%. The analysis found that there were no hexane-soluble impurities in the samples. CONCLUSIONS: None of the analyzed vials contained the stated amount of propofol; however, our analysis did not detect additional contaminants that would explain the adverse events reported by clinicians. Our results confirm the presence of substandard propofol in Zambia; however, anecdotal accounts of substandard anesthetic medicines in other countries abound and warrant further investigation to provide estimates of the prevalence and scope of this global problem.
[Mh] Termos MeSH primário: Anestésicos Intravenosos/análise
Anestésicos Intravenosos/normas
Contaminação de Medicamentos
Propofol/análise
Propofol/normas
[Mh] Termos MeSH secundário: Anestesia
Anestesiologia
Espasmo Brônquico/induzido quimicamente
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Hipotensão/induzido quimicamente
Urticária/induzido quimicamente
Zâmbia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); YI7VU623SF (Propofol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002226


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[PMID]:28551684
[Au] Autor:Mahairidou A; Rodopoulou S; Tomos I; Maratou E; Manali E; Raptakis T; Papiris SA; Karakatsani A
[Ad] Endereço:Department of Anesthesiology and Pain Medicine, Metaxa Hospital, Piraeus, Greece archontiamacheridou@yahoo.com.
[Ti] Título:Exhaled Breath Condensate Acidification Occurs During Surgery for Abdominal Cancer.
[So] Source:Anticancer Res;37(6):3315-3321, 2017 06.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Acidification of exhaled breath condensate (EBC), reflecting airway inflammation and oxidative stress, has been reported in lung cancer patients undergoing lobectomy. We undertook this study to examine EBC pH changes during surgery for abdominal cancer. PATIENTS AND METHODS: EBC pH was measured from 20 patients undergoing abdominal cancer resection before and during surgery. Repeated-measures of ANOVA and random-effects linear models were applied to compare mean EBC pH values in samples collected at different times. Cox and linear regression models were used to determine the association of EBC pH with occurrence of acute bronchospasm intra-operatively and the duration of hospitalization. RESULTS: Significant acidification of EBC was observed during surgery (p=0.007) associated with 0.77% (95% confidence interval=-0.14-1.68, p-value=0.097) increase in the risk for developing acute bronchospasm, after adjustment for potential confounders. CONCLUSION: EBC acidification occurs in patients undergoing abdominal cancer resection and is associated with the occurrence of acute bronchospasm intraoperatively.
[Mh] Termos MeSH primário: Neoplasias Abdominais/cirurgia
Testes Respiratórios
Espasmo Brônquico/etiologia
Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos
Expiração
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos
Monitorização Intraoperatória/métodos
Procedimentos Cirúrgicos Urológicos/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Espasmo Brônquico/diagnóstico
Espasmo Brônquico/fisiopatologia
Feminino
Seres Humanos
Concentração de Íons de Hidrogênio
Tempo de Internação
Modelos Lineares
Masculino
Meia-Idade
Valor Preditivo dos Testes
Modelos de Riscos Proporcionais
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28144025
[Au] Autor:Arshad H; Khan RR; Khaja M
[Ad] Endereço:Division of Pulmonary and Critical Care Medicine, Bronx Lebanon Hospital Center, Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.
[Ti] Título:Case Report of S1Q3T3 Electrocardiographic Abnormality in a Pregnant Asthmatic Patient During Acute Bronchospasm.
[So] Source:Am J Case Rep;18:110-113, 2017 Feb 01.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Asthma is the most common chronic pulmonary disease during pregnancy. Several previous reports have documented reversible electrocardiographic changes during severe acute asthma attacks, including tachycardia, P pulmonale, right bundle branch block, right axis deviation, and ST segment and T wave abnormalities. CASE REPORT We present the case of a pregnant patient with asthma exacerbation in which acute bronchospasm caused S1Q3T3 abnormality on an electrocardiogram (ECG). The complete workup of ECG findings of S1Q3T3 was negative and correlated with bronchospasm. The S1Q3T3 electrocardiographic abnormality can be seen in acute bronchospasm in pregnant women. The other causes like pulmonary embolism, pneumothorax, acute lung disease, cor pulmonale, and left posterior fascicular block were excluded. CONCLUSIONS Asthma exacerbations are of considerable concern during pregnancy due to their adverse effect on the fetus, and optimization of asthma treatment during pregnancy is vital for achieving good outcomes. Prompt recognition of electrocardiographic abnormality and early treatment can prevent adverse perinatal outcomes.
[Mh] Termos MeSH primário: Asma/diagnóstico
Asma/fisiopatologia
Espasmo Brônquico/diagnóstico
Espasmo Brônquico/fisiopatologia
Eletrocardiografia
Sistema de Condução Cardíaco/fisiopatologia
Complicações na Gravidez/diagnóstico
Complicações na Gravidez/fisiopatologia
[Mh] Termos MeSH secundário: Asma/prevenção & controle
Espasmo Brônquico/prevenção & controle
Eletrocardiografia/métodos
Feminino
Seres Humanos
Gravidez
Complicações na Gravidez/prevenção & controle
Resultado da Gravidez
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170324
[Lr] Data última revisão:
170324
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE


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[PMID]:28041785
[Au] Autor:Rosenbrier Ribeiro L; Ian Storer R
[Ad] Endereço:Discovery Safety, Drug Safety and Metabolism, AstraZeneca, Cambridge Science Park, Cambridge, United Kingdom. Electronic address: Lyn.Rosenbrierribeiro@AstraZeneca.com.
[Ti] Título:A semi-quantitative translational pharmacology analysis to understand the relationship between in vitro ENT1 inhibition and the clinical incidence of dyspnoea and bronchospasm.
[So] Source:Toxicol Appl Pharmacol;317:41-50, 2017 Feb 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Adenosine contributes to the pathophysiology of respiratory disease, and adenosine challenge leads to bronchospasm and dyspnoea in patients. The equilibrative nucleoside transporter 1 (ENT1) terminates the action of adenosine by removal from the extracellular environment. Therefore, it is proposed that inhibition of ENT1 in respiratory disease patients leads to increased adenosine concentrations, triggering bronchospasm and dyspnoea. This study aims to assess the translation of in vitro ENT1 inhibition to the clinical incidence of bronchospasm and dyspnoea in respiratory disease, cardiovascular disease and healthy volunteer populations. Four marketed drugs with ENT1 activity were assessed; dipyridamole, ticagrelor, draflazine, cilostazol. For each patient population, the relationship between in vitro ENT1 [ H]-NBTI binding affinity (K ) and [ H]-adenosine uptake (IC ) to the incidence of: (1) bronchospasm/severe dyspnoea; (2) tolerated dyspnoea and; (3) no adverse effects, was evaluated. A high degree of ENT1 inhibition (≥13.3x K , ≥4x IC ) associated with increased incidence of bronchospasm/severe dyspnoea for patients with respiratory disease only, whereas a lower degree of ENT1 inhibition (≥0.1x K , ≥0.05x IC ) associated with a tolerable level of dyspnoea in both respiratory and cardiovascular disease patients. ENT1 inhibition had no effect in healthy volunteers. Furthermore, physicochemical properties correlative with ENT1 binding were assessed using a set of 1625 diverse molecules. Binding to ENT1 was relatively promiscuous (22% compounds K <1µM) especially for neutral or basic molecules, and greater incidence tracked with higher lipophilicity (clogP >5). This study rationalises inclusion of an assessment of ENT1 activity during early safety profiling for programs targeting respiratory disorders.
[Mh] Termos MeSH primário: Espasmo Brônquico/epidemiologia
Dispneia/epidemiologia
Transportador Equilibrativo 1 de Nucleosídeo/antagonistas & inibidores
Pesquisa Médica Translacional/métodos
[Mh] Termos MeSH secundário: Adenosina/análogos & derivados
Adenosina/farmacologia
Adenosina/uso terapêutico
Animais
Espasmo Brônquico/tratamento farmacológico
Ensaios Clínicos como Assunto/métodos
Dipiridamol/farmacologia
Dipiridamol/uso terapêutico
Dispneia/tratamento farmacológico
Seres Humanos
Incidência
Piperazinas/farmacologia
Piperazinas/uso terapêutico
Tetrazóis/farmacologia
Tetrazóis/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Equilibrative Nucleoside Transporter 1); 0 (Piperazines); 0 (SLC29A1 protein, human); 0 (Tetrazoles); 0Y25DT968Y (draflazine); 64ALC7F90C (Dipyridamole); GLH0314RVC (Ticagrelor); K72T3FS567 (Adenosine); N7Z035406B (cilostazol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:27918350
[Au] Autor:Dogruel D; Erbay A; Yazici N; Arslan A; Hasbay Biçen B
[Ad] Endereço:Departments of *Pediatric Allergy and Immunology †Pediatric Hematology and Oncology ‡Pediatric Cardiology §Pathology, Adana Teaching and Medical Research Center, Baskent University Faculty of Medicine, Adana, Turkey.
[Ti] Título:A Case of Idiopathic Pulmonary Hemosiderosis Presenting With Signs and Symptoms Mimicking Hemolytic Anemia.
[So] Source:J Pediatr Hematol Oncol;39(1):e15-e17, 2017 Jan.
[Is] ISSN:1536-3678
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Idiopathic pulmonary hemosiderosis is primarily a disorder of childhood, which is characterized by hemoptysis, iron deficiency anemia, and diffuse parenchymal infiltrates on chest x-ray secondary to recurrent attacks of alveolar hemorrhage. It can be diagnosed by showing hemosiderin laden macrophages in bronchoalveolar lavage fluid after other specific causes of diffuse alveolar hemorrhage are definitely excluded. A 5-year-old male patient was admitted to our clinic with sudden-onset pallor during iron therapy given for anemia. While he was being investigated for clinical and laboratory signs mimicking hemolytic anemia, he developed cough and dyspnea. He had infiltrates on chest x-ray and scattered patchy infiltrates in both lungs on high-resolution computed tomography. Hemosiderin laden macrophages were identified in fasting gastric juice and bronchoalveolar lavage fluid. The patient was diagnosed with idiopathic pulmonary hemosiderosis and started corticosteroid therapy.
[Mh] Termos MeSH primário: Hemossiderose/diagnóstico
Pneumopatias/diagnóstico
[Mh] Termos MeSH secundário: Anemia Hemolítica/diagnóstico
Anemia Ferropriva/etiologia
Espasmo Brônquico/complicações
Espasmo Brônquico/tratamento farmacológico
Líquido da Lavagem Broncoalveolar/citologia
Pré-Escolar
Diagnóstico Diferencial
Dispneia/etiologia
Suco Gástrico/citologia
Hemorragia/complicações
Hemossiderina/análise
Hemossiderose/sangue
Hemossiderose/complicações
Hemossiderose/tratamento farmacológico
Seres Humanos
Pulmão/diagnóstico por imagem
Pneumopatias/sangue
Pneumopatias/complicações
Pneumopatias/tratamento farmacológico
Macrófagos Alveolares/química
Masculino
Prednisolona/uso terapêutico
Transposição dos Grandes Vasos/complicações
Transposição dos Grandes Vasos/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
9011-92-1 (Hemosiderin); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27477835
[Au] Autor:Ahn HJ; Lee JW; Ryu S; Yoo SW; Park SI
[Ad] Endereço:Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
[Ti] Título:Bridge to recovery using extracorporeal membrane oxygenation for critical tracheal stenosis complicating refractory bronchospasm.
[So] Source:Am J Emerg Med;35(1):197.e1-197.e2, 2017 Jan.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Espasmo Brônquico/terapia
Oxigenação por Membrana Extracorpórea/métodos
Stents
Estenose Traqueal/terapia
[Mh] Termos MeSH secundário: Idoso
Espasmo Brônquico/complicações
Feminino
Seres Humanos
Imagem Tridimensional
Recidiva
Tomografia Computadorizada por Raios X
Estenose Traqueal/complicações
Traqueostomia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


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[PMID]:27998167
[Au] Autor:Idani E; Dastoorpoor M; Goudarzi G; Khanjani N
[Ad] Endereço:Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
[Ti] Título:Severe Outbreaks of Respiratory Syndromes Following Autumn Rainfall in Khuzestan, Iran.
[So] Source:Arch Iran Med;19(12):884-885, 2016 Dec.
[Is] ISSN:1735-3947
[Cp] País de publicação:Iran
[La] Idioma:eng
[Mh] Termos MeSH primário: Surtos de Doenças
Umidade
Chuvas
Doenças Respiratórias/epidemiologia
Estações do Ano
[Mh] Termos MeSH secundário: Alérgenos/imunologia
Espasmo Brônquico/epidemiologia
Espasmo Brônquico/imunologia
Tosse/epidemiologia
Tosse/imunologia
Dispneia/epidemiologia
Dispneia/imunologia
Serviço Hospitalar de Emergência
Seres Humanos
Irã (Geográfico)/epidemiologia
Pólen/imunologia
Hipersensibilidade Respiratória/epidemiologia
Hipersensibilidade Respiratória/imunologia
Doenças Respiratórias/imunologia
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE
[do] DOI:0161912/AIM.0014


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[PMID]:27541679
[Au] Autor:Madias JE
[Ad] Endereço:Icahn School of Medicine at Mount Sinai, New York, NY, United States; Division of Cardiology, Elmhurst Hospital Center, Elmhurst, NY, United States. Electronic address: madiasj@nychhc.org.
[Ti] Título:Takotsubo syndrome due to peri-anesthesia anaphylaxis, bronchosmasm per se, albuterol, or epinephrine? Dissecting the triggers.
[So] Source:Int J Cardiol;223:299, 2016 Nov 15.
[Is] ISSN:1874-1754
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Albuterol/efeitos adversos
Anafilaxia/induzido quimicamente
Espasmo Brônquico/induzido quimicamente
Epinefrina/efeitos adversos
Cardiomiopatia de Takotsubo/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Anafilaxia/complicações
Anafilaxia/diagnóstico por imagem
Espasmo Brônquico/complicações
Espasmo Brônquico/diagnóstico por imagem
Feminino
Seres Humanos
Complicações Intraoperatórias/induzido quimicamente
Complicações Intraoperatórias/diagnóstico por imagem
Cardiomiopatia de Takotsubo/complicações
Cardiomiopatia de Takotsubo/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
QF8SVZ843E (Albuterol); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160820
[St] Status:MEDLINE


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[PMID]:27468462
[Au] Autor:Agrawal N; Akella A; Deshpande SB
[Ti] Título:Captopril augments acetylcholine-induced bronchial smooth muscle contractions in vitro via kinin-dependent mechanisms.
[So] Source:Indian J Exp Biol;54(6):365-9, 2016 Jun.
[Is] ISSN:0019-5189
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:Angiotensin converting enzyme (ACE) inhibitors therapy is aassociated with bothersome dry cough as an adverse effect. The mechanisms underlying this adverse effect are not clear. Therefore, influence of captopril (an ACE inhibitor) on acetylcholine (ACh)-induced bronchial smooth muscle contractions was investigated. Further, the mechanisms underlying the captopril-induced changes were also explored. In vitro contractions of rat bronchial smooth muscle to cumulative concentrations of ACh were recorded before and after exposure to captopril. Further, the involvement of kinin and inositol triphosphate (IP3) pathways for captopril-induced alterations were explored. ACh produced concentration-dependent (5-500 µM) increase in bronchial smooth muscle contractions. Pre-treatment with captopril augmented the ACh-induced contractions at each concentration significantly. Pre-treatment with aprotinin (kinin synthesis inhibitor) or heparin (inositol triphosphate, IP3-inhibitor), blocked the captopril-induced augmentation of bronchial smooth muscle contractions evoked by ACh. Further, captopril-induced augmentation was absent in calcium-free medium. These results suggest that captopril sensitizes bronchial smooth muscles to ACh-induced contractions. This sensitization may be responsible for dry cough associated with captopril therapy.
[Mh] Termos MeSH primário: Acetilcolina/efeitos adversos
Inibidores da Enzima Conversora de Angiotensina/efeitos adversos
Brônquios/efeitos dos fármacos
Captopril/efeitos adversos
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Espasmo Brônquico/induzido quimicamente
Tosse/induzido quimicamente
Sinergismo Farmacológico
Cininas/metabolismo
Masculino
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Angiotensin-Converting Enzyme Inhibitors); 0 (Kinins); 9G64RSX1XD (Captopril); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160729
[Lr] Data última revisão:
160729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE


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[PMID]:27362849
[Au] Autor:Palacios A; Mencía S; Llorente AM; Cruz J; Toledo B; Ordóñez O; Olmedilla M; Lopez-Herce J
[Ad] Endereço:1Pediatric Intensive Care Unit, Department of Pediatrics, 12 de Octubre University Hospital, Madrid, Spain. 2Pediatric Intensive Care Unit, Department of Pediatrics, Gregorio Marañón University Hospital, Madrid, Spain. 3Department of Pediatrics, Medicine School, Complutense University of Madrid, Madrid, Spain. 4Mother-Child Health and Development Network (Red SAMID) of Carlos III Health Institute, RETICS funded by the PN I+D+I 2008-2011, Madrid, Spain. 5ISCIII- Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF) ref RD12/0026, Madrid, Spain. 6Pediatric Endocrinology Unit, Department of Pediatrics, 12 de Octubre University Hospital, Madrid, Spain.
[Ti] Título:Sevoflurane Therapy for Severe Refractory Bronchospasm in Children.
[So] Source:Pediatr Crit Care Med;17(8):e380-4, 2016 Aug.
[Is] ISSN:1529-7535
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To describe the effect of inhaled sevoflurane in the treatment of severe refractory bronchospasm in children. DESIGN: Retrospective case series. SETTING: Two PICUs of tertiary general university hospitals in Spain. PATIENTS: Ten patients ranging from 5 months to 14 years old with severe bronchospasm and acute respiratory failure requiring tracheal intubation and mechanical ventilation and treated with sevoflurane from 2008 to 2015. INTERVENTION: Inhaled sevoflurane therapy was initiated after failure of conventional medical management and mechanical ventilation. In two patients, sevoflurane was administered through a Servo 900C ventilator (Maquet, Bridgewater, NJ) equipped with a vaporizer and in the other eight patients via the Anesthetic Conserving Device (AnaConDa; Sedana medical, Uppsala, Sweden) with a critical care ventilator. MEASUREMENTS AND MAIN RESULTS: Inhaled sevoflurane resulted in statistically significant decreases of PaCO2 of 34.2 torr (95% CI, 8.3-60), peak inspiratory pressure of 14.3 cm H2O (95% CI, 8.6-19.9), and improvement in pH of 0.17 (0.346-0.002) within 6 hours of administration. Only one patient presented hypotension responsive to volume administration at the beginning of the treatment. All patients could be extubated within a median time of 120 hours (interquartile range, 46-216). CONCLUSIONS: Inhaled sevoflurane therapy decreases the levels of PaCO2 and peak inspiratory pressure values, and it may be considered as a rescue therapy in patients with life-threatening bronchospasm refractory to conventional therapy.
[Mh] Termos MeSH primário: Espasmo Brônquico/tratamento farmacológico
Broncodilatadores/uso terapêutico
Éteres Metílicos/uso terapêutico
[Mh] Termos MeSH secundário: Administração por Inalação
Adolescente
Criança
Pré-Escolar
Feminino
Seres Humanos
Lactente
Masculino
Estudos Retrospectivos
Índice de Gravidade de Doença
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Methyl Ethers); 38LVP0K73A (sevoflurane)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1097/PCC.0000000000000852



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