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[PMID]:29268637
[Au] Autor:Melani AS; Lanzarone N; Rottoli P
[Ad] Endereço:a Fisiopatologia e Riabilitazione Respiratoria, Dipartimento Vasi, Cuore e Torace, Policlinico Le Scotte , Azienda Ospedaliera Universitaria Senese , Siena , Italy.
[Ti] Título:The pharmacological treatment of bronchiectasis.
[So] Source:Expert Rev Clin Pharmacol;11(3):245-258, 2018 Mar.
[Is] ISSN:1751-2441
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Until recently considered as a minor health problem, the role of bronchiectasis is now increasingly recognized. New specific drugs are being approved for treatment of bronchiectasis. Possibly they will offer better perspectives to bronchiectatic subjects with evolving course. Areas covered: We provide an overview of aetiopathogenesis, clinics and non-pharmacological management, extending the topic of pharmacological treatment. Present therapies were extrapolated from other chronic lung diseases, but newer promising specific drugs are being awaited. Therapy aims at improving mobilisation of bronchial secretions and, if any, reversing airflow obstruction. Antibiotics are indicated to treat exacerbations, eradicate or reduce sputum bacterial load. Expert commentary: Over the last years evidence is mounted that bronchiectatic subjects with accelerated course of disease should be referred to secondary and tertiary centres. This requires increased awareness on the role and the frequency of bronchiectasis in primary care. Long-term continuous or cyclical use of antibiotics is recommended to stabilize or improve the course of evolving disease. Macrolides are a currently preferred option. Inhaled antibiotics are gaining importance and are the object of ongoing research interest. Practical challenges of inhaled antibiotic treatment remain the need of defining the best therapeutic regimen and optimizing true adherence.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Bronquiectasia/tratamento farmacológico
Desenho de Drogas
[Mh] Termos MeSH secundário: Administração por Inalação
Obstrução das Vias Respiratórias/tratamento farmacológico
Obstrução das Vias Respiratórias/etiologia
Bronquiectasia/microbiologia
Bronquiectasia/patologia
Seres Humanos
Macrolídeos/administração & dosagem
Adesão à Medicação
Escarro
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Macrolides)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1080/17512433.2018.1421064


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[PMID]:29390276
[Au] Autor:Li HY; Guo Q
[Ad] Endereço:Department of Primary Care.
[Ti] Título:Could Chinese herbs accelerate the resolution of reversible bronchiectasis in adults?: A case report.
[So] Source:Medicine (Baltimore);96(50):e8883, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: The classic definition of bronchiectasis is of permanent bronchial dilatation. Therefore, bronchiectasis is generally considered irreversible in the adult population. PATIENT CONCERNS: A 27-year-old woman presented to an affiliated hospital with a 1-year history of productive cough. DIAGNOSIS: Bronchiectasis. INTERVENTIONS: The patient was treated with cephalosporin and a mucus clearance regimen for 6 days and then with Chinese herbs for 3 months. OUTCOMES: Reversible bronchial dilatation was evidenced by sequential chest high-resolution computed tomography 6 months later. CONCLUSION: The current report demonstrated that, although rare in adult, bronchial dilatation might resolve completely in such a short period if receiving adequate regimens, for example, Chinese herbs.
[Mh] Termos MeSH primário: Bronquiectasia/tratamento farmacológico
Medicamentos de Ervas Chinesas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Bronquiectasia/diagnóstico por imagem
Cefalosporinas/uso terapêutico
Quimioterapia Combinada
Feminino
Seres Humanos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008883


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[PMID]:29443739
[Au] Autor:Dos Santos DO; de Souza HCD; Baddini-Martinez JA; Ramos EMC; Gastaldi AC
[Ad] Endereço:Department of Physiotherapy.
[Ti] Título:Effects of exercise on secretion transport, inflammation, and quality of life in patients with noncystic fibrosis bronchiectasis: Protocol for a randomized controlled trial.
[So] Source:Medicine (Baltimore);97(7):e9768, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bronchiectasis is characterized by pathological and irreversible bronchial dilatation caused by the inefficient mucus and microorganism clearance and progression of inflammatory processes. The most frequent characteristic is the increase in bronchial mucus production resulting in slower transport and damage to the mucociliary transport. AIMS: To evaluate the effects of exercise on mucus transport, inflammation, and resistance of the respiratory and autonomic nervous systems and subsequent effects on quality of life in patients with bronchiectasis who are enrolled in a pulmonary rehabilitation program. METHODS: Sixty subjects of both sexes between 18 and 60 years (30 volunteers with clinically stable bronchiectasis and 30 healthy volunteers) will be included. Participants with chronic obstructive pulmonary disease, decompensated cardiovascular or metabolic diseases, neuromuscular and musculoskeletal diseases, and active smokers will be excluded. Volunteers will be randomly allocated to the pulmonary rehabilitation or control groups. The primary outcomes will be nasal transport time as evaluated by nasal saccharin transport time, analysis of nasal lavage, enzyme immunoassay of exhaled expiration, and analysis of the mucus properties. The secondary outcomes will include pulmonary function tests, impulse oscillometry, heart rate variability analysis, and quality of life questionnaires. DISCUSSION: In addition to the benefits for patients already described in the literature, the additional benefit of mucus removal may contribute to optimizing treatments and better control of the disease. CONCLUSION: This protocol could provide new information about the unclear mechanisms regarding exercise to aid in the removal of secretions.
[Mh] Termos MeSH primário: Bronquiectasia/reabilitação
Terapia por Exercício/métodos
Exercício/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Bronquiectasia/metabolismo
Bronquiectasia/fisiopatologia
Protocolos Clínicos
Feminino
Frequência Cardíaca
Seres Humanos
Inflamação
Masculino
Meia-Idade
Depuração Mucociliar
Muco/secreção
Oscilometria
Qualidade de Vida
Testes de Função Respiratória
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009768


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[PMID]:29338445
[Au] Autor:Antoniu SA
[Ad] Endereço:a Department of Medicine II-Nursing/Palliative Care , University of Medicine and Pharmacy Grigore T Popa Iasi , Iasi , Romania.
[Ti] Título:Investigational inhaled therapies for non-CF bronchiectasis.
[So] Source:Expert Opin Investig Drugs;27(2):139-146, 2018 Feb.
[Is] ISSN:1744-7658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Bronchiectasis not related to cystic fibrosis (non-CF bronchiectasis) are associated with a high unmet therapeutic need due to the lack of specifically authorized medications, especially via the inhalation route. In non-CF bronchiectasis chronic infection with Pseudomonas aeruginosa is common and favored by the persistent local inflammation and viscid sputum production. Therefore inhaled antibiotics, mucolytics or anti-inflammatory agents could represent appropriate therapeutic interventions in this setting Areas covered: This review herein discusses the inhaled therapies currently under investigation for non-CF bronchiectasis and their potential therapeutic positioning in exacerbation versus stable state. Expert opinion: Inhaled antipseudomonal antibiotics are of promising efficacy, but further efforts should also be made to detect bactericidal approaches against Burkholderia cepacia complex, and to interfere chronic inflammation topically.
[Mh] Termos MeSH primário: Bronquiectasia/tratamento farmacológico
Desenho de Drogas
Drogas em Investigação/uso terapêutico
[Mh] Termos MeSH secundário: Administração por Inalação
Animais
Antibacterianos/administração & dosagem
Antibacterianos/uso terapêutico
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/uso terapêutico
Bronquiectasia/etiologia
Bronquiectasia/microbiologia
Doença Crônica
Drogas em Investigação/administração & dosagem
Drogas em Investigação/farmacologia
Expectorantes/administração & dosagem
Expectorantes/uso terapêutico
Seres Humanos
Infecções por Pseudomonas/tratamento farmacológico
Pseudomonas aeruginosa
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Inflammatory Agents); 0 (Drugs, Investigational); 0 (Expectorants)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1080/13543784.2018.1427728


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[PMID]:28972989
[Au] Autor:Faria Júnior NS; Urbano JJ; Santos IR; Silva AS; Perez EA; Souza ÂH; Nascimento OA; Jardim JR; Insalaco G; Oliveira LVF; Stirbulov R
[Ad] Endereço:Master's degree and PhD Program in Surgery Research, Santa Casa de Sao Paulo School of Medical Sciences, (FCMSCSP), Sao Paulo (SP), Brazil.
[Ti] Título:Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: A cross-sectional study.
[So] Source:PLoS One;12(10):e0185413, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The relationship between sleep disorders and bronchiectasis has not been well described. We hypothesize that, due to the irreversible dilatation of the bronchi, the presence of secretions, and airflow obstruction, patients with non-cystic fibrosis bronchiectasis may be predisposed to hypoxemia during sleep, or to symptoms that may lead to arousal. A cross-sectional observational study was performed involving 49 patients with a clinical diagnosis of non-cystic fibrosis bronchiectasis (NCFB). All patients underwent clinical evaluation, spirometry, and polysomnography, and were evaluated for the presence of excessive daytime sleepiness (EDS) and risk of obstructive sleep apnea (OSA). The mean age of the participants was 50.3 ± 13.6 years; 51.1% of patients were male and had a mean body mass index of 23.8 ± 3.4 kg/m2. The mean total sleep time (TST) was 325.15 ± 64.22 min with a slight reduction in sleep efficiency (84.01 ± 29.2%). Regarding sleep stages, stage 1 sleep and REM sleep were abnormal. OSA was present in 40.82% of the patients. The mean arousal index was 5.6 ± 2.9/h and snoring was observed in 71.43% of the patients. The oxygen desaturation index (ODI) was 14.35 ± 15.36/h, mean minimum oxygen saturation (SpO2 nadir) was 83.29 ± 7.99%, and mean TST with an SpO2 less than 90% was 30.21 ± 60.48 min. EDS was exhibited by 53.06% of the patients and 55.1% were at high risk of developing OSA. The patients infected by Pseudomonas aeruginosa had higher apnea-hypopnea indices, ODI, and TST with SpO2 < 90%, and lower values of SpO2 nadir. Adult patients with clinically stable NCFB, especially those infected by Pseudomonas aeruginosa, display EDS and a high prevalence of OSA, associated with considerable oxygen desaturation during sleep.
[Mh] Termos MeSH primário: Bronquiectasia/complicações
Apneia Obstrutiva do Sono/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Feminino
Seres Humanos
Masculino
Meia-Idade
Polissonografia
Apneia Obstrutiva do Sono/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185413


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[PMID]:28968457
[Au] Autor:Park TY; Chong S; Jung JW; Park IW; Choi BW; Lim C; Lee CU; Kim YS; Choi HW; Choi JC
[Ad] Endereço:Division of Pulmonary Medicine, Department of Internal Medicine, Chung-Ang University, Chung-Ang University College of Medicine, Seoul, Korea.
[Ti] Título:Natural course of the nodular bronchiectatic form of Mycobacterium Avium complex lung disease: Long-term radiologic change without treatment.
[So] Source:PLoS One;12(10):e0185774, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/PURPOSE: Although the incidence of Mycobacterium avium complex (MAC) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of MAC lung disease is not well described. The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by analyzing serial chest computed tomography (CT) scan findings. METHODS: Of 104 patients with MAC lung disease, we selected 40 untreated nodular bronchiectatic MAC patients who underwent serial chest CTs without treatment for at least four years (mean = 6.23 years). Majority of patients have minimal symptoms. Two chest radiologists retrospectively reviewed initial and final chest CT scans. Each chest CT scan was scored for presence and extent of bronchiectasis, cellular bronchiolitis, consolidation, cavity, and nodule (maximum score: 30). RESULTS: Of 40 patients, 39 (97.5%) experienced a significant increase in overall CT score (overall difference = 4.89, p<0.001). On repeated measure analysis of variance analysis, cavity yielded the largest increase compared with cellular bronchiolitis (p = 0.013), nodule (p<0.001), and consolidation (p = 0.004). However, there was no significant difference in mean score change between cavity and bronchiectasis (p = 0.073). In analysis between radiologic parameters and the absolute number of involved segments, bronchiectasis showed most significant change compared with nodule (p<0.001) and consolidation (p<0.001). CONCLUSIONS: Most untreated nodular bronchiectatic MAC lung disease cases showed radiologic deterioration over long-term observation periods when we compared serial chest CT scans. Careful monitoring of MAC lung disease with serial chest CT scan can be beneficial in these untreated patients.
[Mh] Termos MeSH primário: Bronquiectasia/patologia
Pneumopatias/patologia
Infecção por Mycobacterium avium-intracellulare/patologia
[Mh] Termos MeSH secundário: Idoso
Bronquiectasia/diagnóstico por imagem
Feminino
Seres Humanos
Pneumopatias/diagnóstico por imagem
Masculino
Meia-Idade
Infecção por Mycobacterium avium-intracellulare/diagnóstico por imagem
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171003
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185774


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[PMID]:28957340
[Au] Autor:Schweitzer MD; Salamo O; Campos M; Schraufnagel DE; Sadikot R; Mirsaeidi M
[Ad] Endereço:Section of Pulmonary, Department of Medicine, Miami VA Medical Center, Miami, FL, United States of America.
[Ti] Título:Body habitus in patients with and without bronchiectasis and non-tuberculous mycobacteria.
[So] Source:PLoS One;12(9):e0185095, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Female gender, tall stature, presence of bronchiectasis are associated with pulmonary nontuberculous mycobacterial (NTM) infections. The biologic relationship between the body habitus and NTM infection is not well defined and the body habitus profile of the patients with NTM and concurrent bronchiectasis is completely unknown. METHODS: We conducted a case control study at the Miami VA Healthcare System and the University of Illinois Medical Center on patients with pulmonary NTM infections between 2010 and 2015. We compared pulmonary NTM subjects with and without bronchiectasis. NTM infection was confirmed by using the American Thoracic Society/ Infectious Disease Society of America criteria. Standard radiological criteria were used to define bronchiectasis in chest CT-scan. RESULTS: Two hundred twenty subjects with pulmonary NTM were enrolled in the study. Sixty six subjects (30%) had bronchiectasis on CT scan of the chest. Subjects in the bronchiectasis group included more women (p = 0.002) and were significantly older (p = 0.005). Those patients who had bronchiectasis tended to have a significantly lower weight (less than 50kg) and height ≤155 cm (p <0.0001 and p = 0.018, respectively). Kaplan-Meier analysis confirmed that subjects who had bronchiectasis were shorter and weighed less, after adjusting for gender. CONCLUSIONS: This study defines a new sub-phenotype of NTM subjects with bronchiectasis who tend to be short with lower body weight. Further studies are needed to better understand and define the body habitus profiles of this new sub-phenotype and their clinical implications.
[Mh] Termos MeSH primário: Bronquiectasia/complicações
Infecções por Micobactéria não Tuberculosa/complicações
Infecções por Micobactéria não Tuberculosa/microbiologia
Micobactérias não Tuberculosas/fisiologia
[Mh] Termos MeSH secundário: Idoso
Peso Corporal
Bronquiectasia/patologia
Comorbidade
Demografia
Feminino
Seres Humanos
Classificação Internacional de Doenças
Estimativa de Kaplan-Meier
Masculino
Análise Multivariada
Infecções por Micobactéria não Tuberculosa/diagnóstico por imagem
Micobactérias não Tuberculosas/isolamento & purificação
Fatores de Risco
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185095


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[PMID]:28889896
[Au] Autor:Debray MP; Marceau A; Dombret MC; Bunel V; Leroy S; Deslée G; Mal H
[Ad] Endereço:Service de Radiologie, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
[Ti] Título:Bronchiectasis Complicating Lung Volume Reduction Coil Treatment.
[So] Source:Chest;152(3):e57-e60, 2017 Sep.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Endoscopic lung volume reduction has emerged over the past several years as a promising technique to improve the respiratory functional status of patients with advanced emphysema. Nevertheless, the procedure may be associated with various complications; among them, the development of bronchiectasis related to the coils has not yet been described. We report the case of a patient with emphysema who developed localized bronchiectasis at the site of coil insertion several months after lung volume reduction coil treatment.
[Mh] Termos MeSH primário: Bronquiectasia/etiologia
Pneumonectomia/efeitos adversos
Pneumonectomia/instrumentação
Complicações Pós-Operatórias/etiologia
Enfisema Pulmonar/cirurgia
[Mh] Termos MeSH secundário: Bronquiectasia/diagnóstico por imagem
Seres Humanos
Masculino
Meia-Idade
Complicações Pós-Operatórias/diagnóstico por imagem
Enfisema Pulmonar/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE


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[PMID]:28886040
[Au] Autor:Guan WJ; Yuan JJ; Huang Y; Li HM; Chen RC; Zhong NS
[Ad] Endereço:State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
[Ti] Título:Residual volume/total lung capacity ratio confers limited additive significance to lung clearance index for assessment of adults with bronchiectasis.
[So] Source:PLoS One;12(9):e0183779, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mosaicism and hyperinflation are common pathophysiologic features of bronchiectasis. The magnitude of ventilation heterogeneity might have been affected by the degree of hyperinflation. Some studies have evaluated the discriminative performance of lung clearance index (LCI) in bronchiectasis patients, but the additive diagnostic value of hyperinflation metrics to LCI is unknown. OBJECTIVE: To compare LCI and the ratio of residual volume to total lung capacity (RV/TLC), along with the LCI normalized with RV/TLC, in terms of discriminative performance, correlation and concordance with clinical variables in adults with bronchiectasis. METHODS: Measurement items included chest high-resolution computed tomography, multiple-breath nitrogen washout test, spirometry, and sputum culture. We analyzed bronchodilator responses by stratifying LCI and RV/TLC according to their median levels (LCIHigh/RV/TLCHigh, LCILow/RV/TLCHigh, LCIHigh/RV/TLCLow, and LCILow/RV/TLCLow). RESULTS: Data from 127 adults with clinically stable bronchiectasis were analyzed. LCI had greater diagnostic value than RV/TLC in discriminating moderate-to-severe from mild bronchiectasis, had greater concordance in reflecting clinical characteristics (including the number of bronchiectatic lobes, radiological severity score, and the presence of cystic bronchiectasis). Normalization of LCI with RV/TLC did not contribute to greater discriminative performance or concordance with clinical variables. The LCI, before and after normalization with RV/TLC, correlated statistically with age, sex, HRCT score, Pseudomonas aeruginosa colonization, cystic bronchiectasis, and ventilation heterogeneity (all P<0.05). Different bronchodilator responses were not significant among the four subgroups of bronchiectasis patients, including those with discordant LCI and RV/TLC levels. CONCLUSION: LCI is superior to RV/TLC for bronchiectasis assessment. Normalization with RV/TLC is not required. Stratification of LCI and RV/TLC is not associated with significantly different bronchodilator responses.
[Mh] Termos MeSH primário: Bronquiectasia/fisiopatologia
Pulmão/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Volume Expiratório Forçado/fisiologia
Seres Humanos
Masculino
Meia-Idade
Volume Residual/fisiologia
Testes de Função Respiratória
Espirometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183779


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[PMID]:28829833
[Au] Autor:Byun MK; Chang J; Kim HJ; Jeong SH
[Ad] Endereço:Division of Pulmonology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
[Ti] Título:Differences of lung microbiome in patients with clinically stable and exacerbated bronchiectasis.
[So] Source:PLoS One;12(8):e0183553, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Molecular-based diagnostic techniques can compensate for the inherent limitations of culture-based microbiology and provide a more comprehensive description of an entire community of bacteria at a particular anatomical site. Using culture-independent DNA-based molecular techniques, the aim of the present study was to characterize, differentiate, and compare the composition of lower airway bacterial microbiome between clinically stable and acutely infected patients with bronchiectasis experiencing exacerbation. METHODS: Patients with clinically stable bronchiectasis and those experiencing acutely exacerbated bronchiectasis were recruited. All patients underwent bronchoscopy. Paired sputum and bronchoalveolar lavage (BAL) samples were collected for microbiological tests. Molecular analysis was performed for BAL samples using 16S ribosomal RNA (rRNA) gene sequencing. RESULTS: The mean age of the 14 recruited patients was 60 years (range 42 to 78 years), and nine (64%) were female. Using quantitative culture and 16S rRNA sequencing, the common organisms identified from 14 BAL samples were Haemophilus influenzae, Pseudomonas aeruginosa and Moraxella catarrhalis, and Prevotella. Molecular techniques revealed Prevotella and Veillonella as potentially pathogenic anaerobic species. 16S rRNA gene sequencing yielded similar relative abundances and distributions of taxa in the stable and exacerbated bronchiectasis groups. Alpha diversity with richness, Simpson's and Shannon indices, and beta diversity using principal coordinate analysis revealed no significant differences in lung microbiome between patients with clinically stable and exacerbated bronchiectasis. CONCLUSION: Culture-based microbiological and molecular-based techniques did not reveal significant differences in the lung microbiome of patients who were clinically stable and those experiencing exacerbated bronchiectasis. Patient-specific microbial communities were dominated by one or several genera, regardless of clinical status. DNA sequencing could identify potentially pathogenic organisms unable to be identified using microbiological methods.
[Mh] Termos MeSH primário: Bronquiectasia/microbiologia
Pulmão/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Adulto
Idoso
Bactérias/classificação
Bactérias/genética
Bronquiectasia/patologia
Líquido da Lavagem Broncoalveolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183553



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