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[PMID]:28614400
[Au] Autor:Soumagne T; Chardon ML; Dournes G; Laurent L; Degano B; Laurent F; Dalphin JC
[Ad] Endereço:Service de Pneumologie, CHU de Besançon, Besançon, France.
[Ti] Título:Emphysema in active farmer's lung disease.
[So] Source:PLoS One;12(6):e0178263, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Farmer's lung (FL) is a common type of hypersensitivity pneumonitis. It is often considered that fibrosis is the most frequent finding in chronic FL. Nevertheless, three cohort studies have suggested that some patients with chronic FL may develop emphysema. We aimed to evaluate the current prevalence of emphysema in active FL, to describe the radiological and functional features of emphysema in active FL, and to identify risk factors associated with emphysema in this population. METHODS: Patients aged over 18 years with active FL were prospectively recruited through the SOPHIA study (CPP Est; P-2009-521), between 2007 and 2015. Each patient had complete medical history screening, clinical examination, high resolution computed tomodensitometry, bronchoalveolar lavage, pulmonary function tests and serum precipitins. RESULTS: Among 33 patients with active FL, the prevalence of emphysema in this series of incident active FL cases was higher (48.5%) than that of fibrosis (12%) and was not dependent on smoking habits. Most patients with emphysema did not have lung hyperinflation. The possible risk factors for emphysema in active FL were a longer duration of exposure to organic dusts, and at a higher level. CONCLUSION: Emphysema is found in half of patients with active FL and may be influenced by exposure patterns.
[Mh] Termos MeSH primário: Pulmão de Fazendeiro/complicações
Enfisema Pulmonar/diagnóstico
Enfisema Pulmonar/epidemiologia
[Mh] Termos MeSH secundário: Idoso
Animais
Lavagem Broncoalveolar
Poeira/análise
Pulmão de Fazendeiro/fisiopatologia
Feminino
Fibrose
Abrigo para Animais
Seres Humanos
Masculino
Meia-Idade
Testes de Precipitina
Estudos Prospectivos
Testes de Função Respiratória
Fatores de Risco
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dust)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178263


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[PMID]:27490813
[Au] Autor:Rognon B; Barrera C; Monod M; Valot B; Roussel S; Quadroni M; Jouneau S; Court-Fortune I; Caillaud D; Fellrath JM; Dalphin JC; Reboux G; Millon L
[Ad] Endereço:UMR6249 Chrono-Environnement, University of Bourgogne Franche-Comté, Besançon, France.
[Ti] Título:Identification of Antigenic Proteins from Lichtheimia corymbifera for Farmer's Lung Disease Diagnosis.
[So] Source:PLoS One;11(8):e0160888, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of recombinant antigens has been shown to improve both the sensitivity and the standardization of the serological diagnosis of Farmer's lung disease (FLD). The aim of this study was to complete the panel of recombinant antigens available for FLD serodiagnosis with antigens of Lichtheimia corymbifera, known to be involved in FLD. L. corymbifera proteins were thus separated by 2D electrophoresis and subjected to western blotting with sera from 7 patients with FLD and 9 healthy exposed controls (HEC). FLD-associated immunoreactive proteins were identified by mass spectrometry based on a protein database specifically created for this study and subsequently produced as recombinant antigens. The ability of recombinant antigens to discriminate patients with FLD from controls was assessed by ELISA performed with sera from FLD patients (n = 41) and controls (n = 43) recruited from five university hospital pneumology departments of France and Switzerland. Forty-one FLD-associated immunoreactive proteins from L. corymbifera were identified. Six of them were produced as recombinant antigens. With a sensitivity and specificity of 81.4 and 77.3% respectively, dihydrolipoyl dehydrogenase was the most effective antigen for discriminating FLD patients from HEC. ELISA performed with the putative proteasome subunit alpha type as an antigen was especially specific (88.6%) and could thus be used for FLD confirmation. The production of recombinant antigens from L. corymbifera represents an additional step towards the development of a standardized ELISA kit for FLD diagnosis.
[Mh] Termos MeSH primário: Antígenos de Fungos/metabolismo
Pulmão de Fazendeiro/diagnóstico
Mucorales/metabolismo
[Mh] Termos MeSH secundário: Antígenos de Fungos/classificação
Antígenos de Fungos/genética
Antígenos de Fungos/imunologia
Western Blotting
Estudos de Casos e Controles
Bases de Dados Genéticas
Eletroforese em Gel Bidimensional
Ensaio de Imunoadsorção Enzimática
Pulmão de Fazendeiro/microbiologia
Feminino
Seres Humanos
Imunoglobulina G/sangue
Masculino
Espectrometria de Massas
Mucorales/genética
Mucorales/isolamento & purificação
RNA Fúngico/isolamento & purificação
RNA Fúngico/metabolismo
RNA Mensageiro/química
RNA Mensageiro/metabolismo
Proteínas Recombinantes/biossíntese
Proteínas Recombinantes/imunologia
Proteínas Recombinantes/isolamento & purificação
Sensibilidade e Especificidade
Análise de Sequência de RNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Fungal); 0 (Immunoglobulin G); 0 (RNA, Fungal); 0 (RNA, Messenger); 0 (Recombinant Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160805
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0160888


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[PMID]:26689249
[Au] Autor:Soumagne T; Pana-Katatali H; Degano B; Dalphin JC
[Ad] Endereço:Department of Respiratory Diseases, University Hospital of Besançon, Besançon, France.
[Ti] Título:Combined pulmonary fibrosis and emphysema in hypersensitivity pneumonitis.
[So] Source:BMJ Case Rep;2015, 2015 Dec 21.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Combined pulmonary fibrosis and emphysema is a distinct syndrome reported in patients who smoke. A 72-year-old, never-smoking female dairy farmer was referred for progressive dyspnoea on exertion, basal crackles on auscultation, normal spirometry and normal lung volumes but decreased diffusing capacity of the lung for carbon monoxide, centrilobular emphysema in the upper zones of the lungs and diffuse infiltrative lung disease in the lower zones on high-resolution CT scan. Bronchoalveolar lavage differential cell count showed 35% lymphocytosis, and precipitating antibodies for Wallemia sebi, Trichoderma species and Cladosporium sphaerospermum were identified. The diagnosis of farmer's lung disease with combined pulmonary fibrosis and emphysema was retained. This case highlights for the first time that hypersensitivity pneumonitis should be suspected in the setting of combined pulmonary fibrosis and emphysema in non-smoking patients.
[Mh] Termos MeSH primário: Alveolite Alérgica Extrínseca/complicações
Pulmão de Fazendeiro/diagnóstico
Enfisema Pulmonar/diagnóstico
Fibrose Pulmonar/diagnóstico
[Mh] Termos MeSH secundário: Idoso
Alveolite Alérgica Extrínseca/diagnóstico
Alveolite Alérgica Extrínseca/fisiopatologia
Pulmão de Fazendeiro/complicações
Pulmão de Fazendeiro/fisiopatologia
Feminino
Seres Humanos
Pulmão/diagnóstico por imagem
Pulmão/fisiopatologia
Capacidade de Difusão Pulmonar
Enfisema Pulmonar/complicações
Enfisema Pulmonar/fisiopatologia
Fibrose Pulmonar/complicações
Fibrose Pulmonar/fisiopatologia
Espirometria
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE


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[PMID]:25847206
[Au] Autor:Soumagne T; Degano B; Dalphin JC
[Ad] Endereço:Service de pneumologie, hôpital Jean-Minjoz, 2, boulevard Fleming, 25030 Besancon cedex, France. Electronic address: thibaud_soumagne@live.fr.
[Ti] Título:[Chronic Farmer's lung disease with emphysema].
[Ti] Título:Forme emphysémateuse de la maladie du poumon de fermier..
[So] Source:Rev Mal Respir;32(3):275-8, 2015 Mar.
[Is] ISSN:1776-2588
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:INTRODUCTION: Farmer's lung (FL) is the most common type of hypersensitivity pneumonitis (HP), with an estimated prevalence of between 0.5 and 1.5% in dairy farmers. In chronic FL, fibrotic sequelae are widely described in the literature although our experience and occasional epidemiological studies emphasize an increased risk of developing emphysema in these patients. CASE REPORT: We report a case of FL in a 37-year-old patient with typical clinical features (exertional dyspnoea, lymphocytic alveolitis and computed tomography appearances) together with proven allergen exposure. This patient developed early pulmonary emphysema probably due to intermittent massive exposure to antigens and to bacterial and fungal micro-organisms. CONCLUSION: The current classification of HP differentiates acute, subacute and chronic forms but does not take account of the role of the mode of exposure and the evolution of the disease. The prognosis and evolution of HP seem to be dependent on the type and pattern of exposure. A new classification with two clusters has been suggested: in type 1, massive and intermittent exposure, as in FL, may lead to emphysema with chronic airflow obstruction and, in type 2, chronic exposure to a low level, as in bird fanciers, may lead to fibrosis with a restrictive pattern.
[Mh] Termos MeSH primário: Pulmão de Fazendeiro/complicações
Enfisema Pulmonar/etiologia
[Mh] Termos MeSH secundário: Adulto
Obstrução das Vias Respiratórias/etiologia
Alérgenos/efeitos adversos
Alveolite Alérgica Extrínseca/classificação
Alveolite Alérgica Extrínseca/etiologia
Alveolite Alérgica Extrínseca/patologia
Alveolite Alérgica Extrínseca/fisiopatologia
Ração Animal/efeitos adversos
Ração Animal/microbiologia
Animais
Antígenos de Bactérias/efeitos adversos
Antígenos de Fungos/efeitos adversos
Progressão da Doença
Poeira
Pulmão de Fazendeiro/diagnóstico
Fibrose
Abrigo para Animais
Seres Humanos
Masculino
Exposição Ocupacional
Prognóstico
Enfisema Pulmonar/diagnóstico
Testes de Função Respiratória
Ventilação
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Bacterial); 0 (Antigens, Fungal); 0 (Dust)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150407
[Lr] Data última revisão:
150407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150408
[St] Status:MEDLINE


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[PMID]:25666836
[Au] Autor:Rognon B; Reboux G; Roussel S; Barrera C; Dalphin JC; Fellrath JM; Monod M; Millon L
[Ad] Endereço:UMR Chrono-Environnement 6249/CNRS, University of Besançon, France Parasitology-Mycology Department, University Hospital, Besançon, France.
[Ti] Título:Western blotting as a tool for the serodiagnosis of farmer's lung disease: validation with Lichtheimia corymbifera protein extracts.
[So] Source:J Med Microbiol;64(Pt 4):359-68, 2015 Apr.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrosyneresis and double diffusion are immunoprecipitation techniques commonly used in the serological diagnosis of Farmer's lung disease (FLD). These techniques are reliable but lack standardization. The aim of this study was to evaluate Western blotting for the serodiagnosis of FLD. We carried out Western blotting with an antigenic extract of Lichtheimia corymbifera, an important aetiological agent of the disease. The membranes were probed with sera from 21 patients with FLD and 21 healthy exposed controls to examine the IgG antibody responses against purified somatic antigens. Given the low prevalence of the disease, 21 patients could be considered as a relevant series. Four bands were significantly more frequently represented in membranes probed with FLD sera (bands at 27.7, 40.5, 44.0 and 50.5 kDa) than those probed with control sera. We assessed the diagnostic value of different criteria alone or in combination. The diagnostic accuracy of the test was highest with the inclusion of at least two of the following criteria: at least five bands on the strip and the presence of one band at 40.5 or 44.0 kDa. Sensitivity, specificity and positive and negative predictive values were all 81%, and the odds ratio was 18.06. Inclusion of bands of high intensity diminished rather than improved the diagnostic value of the test. We concluded that Western blotting is a valuable technique for the serodiagnosis of FLD. The industrial production of ready-to-use membranes would enable the routine use of this technique in laboratories, and provide reliable and standardized diagnostic results within a few hours.
[Mh] Termos MeSH primário: Anticorpos Antifúngicos/sangue
Antígenos de Fungos
Western Blotting/métodos
Pulmão de Fazendeiro/diagnóstico
Mucorales/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anticorpos Antifúngicos/química
Seres Humanos
Imunoglobulina G/sangue
Imunoglobulina G/química
Meia-Idade
Peso Molecular
Valor Preditivo dos Testes
Sensibilidade e Especificidade
Testes Sorológicos/métodos
[Pt] Tipo de publicação:CASE REPORTS; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Fungal); 0 (Antigens, Fungal); 0 (Immunoglobulin G)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150211
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000037


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[PMID]:25344645
[Au] Autor:Liu S; Chen D; Fu S; Ren Y; Wang L; Zhang Y; Zhao M; He X; Wang X
[Ad] Endereço:Department of Respiratory Medicine, The Fourth Affiliated Hospital of China Medical University, 4 East Chongshan Road, Shenyang, 110032, Liaoning, People's Republic of China.
[Ti] Título:Prevalence and risk factors for farmer's lung in greenhouse farmers: an epidemiological study of 5,880 farmers from Northeast China.
[So] Source:Cell Biochem Biophys;71(2):1051-7, 2015 Mar.
[Is] ISSN:1559-0283
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The objectives of this epidemiological study were to evaluate the prevalence of farmer's lung disease (FLD) and to explore the potential risk factors for FLD among Chinese greenhouse farmers. A total of 835 plastic film greenhouses, including 5,880 active farmers who engaged in crop cultivation or poultry farming, were randomly selected from the rural regions of Northeastern China. These farmers participated in the study by answering a medical questionnaire. 5,420 greenhouse farmers accepted and answered questionnaires in full (response rate, 92.18 %). Prevalence of FLD among these farmers was 5.7 % (308/5,420). Besides, a number of classic risk factors for FLD were identified, such as years of age, shorter time interval for re-entry greenhouse, ventilation frequency of greenhouse more than once per 4 h, the area of greenhouses greater than 30 m(2) but without a ventilation facility, ventilation duration less than 30 min every time, greenhouse with height less than 1.8 m, greenhouse with humidity greater than 65 %, frequent exposure to moldy materials in greenhouse, living inside greenhouse, and et al. FLD is and will continue to be a real health problem for Chinese farmers. If these preventive measures are implemented, the prevalence of FLD in Chinese greenhouse farmers might be greatly reduced.
[Mh] Termos MeSH primário: Ambiente Controlado
Pulmão de Fazendeiro/epidemiologia
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Feminino
Seres Humanos
Masculino
Meia-Idade
Prevalência
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150205
[Lr] Data última revisão:
150205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141027
[St] Status:MEDLINE
[do] DOI:10.1007/s12013-014-0308-7


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[PMID]:25264606
[Au] Autor:Barrera C; Millon L; Rognon B; Quadroni M; Roussel S; Dalphin JC; Court-Fortune I; Caillaud D; Jouneau S; Fellrath JM; Zaugg C; Reboux G; Monod M
[Ad] Endereço:UMR6249 Chrono-environnement, University of Franche-Comté, Besançon, France; Parasitology-Mycology Department, University Hospital of Besançon, Besançon, France.
[Ti] Título:Immunoreactive proteins of Saccharopolyspora rectivirgula for farmer's lung serodiagnosis.
[So] Source:Proteomics Clin Appl;8(11-12):971-81, 2014 Dec.
[Is] ISSN:1862-8354
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Saccharopolyspora rectivirgula is the principal cause of farmer's lung disease (FLD). Serodiagnosis is based on immunoprecipitation techniques or enzyme immunoassays with homemade crude antigens and is not standardized. We aimed to produce specific recombinant antigens for the development of a standardized ELISA. EXPERIMENTAL DESIGN: We recruited 41 patients and 43 healthy exposed controls from five university hospital pneumology departments in France and Switzerland. S. rectivirgula proteins were extracted, separated by 2D electrophoresis, and subjected to Western blotting, with sera from FLD patients or controls. FLD-specific proteins were identified by MS and were produced as recombinant antigens. The diagnostic performance of ELISA tests using the recombinant antigens was assessed with all the sera from FLD patients and controls. RESULTS: We identified 25 FLD-specific proteins, some of which play important roles in transport, nutrition, or virulence. We produced 17 of these proteins as recombinant antigens and assessed their suitability for inclusion in the ELISA test. A combination of three of these proteins (SR1FA, SR17, and SR22) proved remarkably effective at discriminating between patients and controls, with a sensitivity of 83% and a specificity of 77%. CONCLUSIONS AND CLINICAL RELEVANCE: The recombinant antigens produced in this study constitute a major step toward the improvement of diagnostic performance and the standardization of FLD serodiagnosis.
[Mh] Termos MeSH primário: Proteínas de Bactérias/imunologia
Pulmão de Fazendeiro/imunologia
Infecções por Bactérias Gram-Positivas/imunologia
Saccharopolyspora/imunologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Western Blotting
Eletroforese em Gel Bidimensional
Ensaio de Imunoadsorção Enzimática
Pulmão de Fazendeiro/diagnóstico
Pulmão de Fazendeiro/microbiologia
Feminino
Infecções por Bactérias Gram-Positivas/diagnóstico
Infecções por Bactérias Gram-Positivas/microbiologia
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Masculino
Espectrometria de Massas
Meia-Idade
Reação em Cadeia da Polimerase
Proteoma/genética
Proteoma/imunologia
Proteoma/metabolismo
Proteômica/métodos
Reprodutibilidade dos Testes
Saccharopolyspora/metabolismo
Saccharopolyspora/fisiologia
Sensibilidade e Especificidade
Testes Sorológicos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Proteome)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141203
[Lr] Data última revisão:
141203
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140930
[St] Status:MEDLINE
[do] DOI:10.1002/prca.201400024


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[PMID]:24959758
[Au] Autor:Chapel D; Scribani M; Krupa N; Shaw B; Bell E; Jenkins P
[Ad] Endereço:a Bassett Healthcare Network, Research Institute, Cooperstown , New York , USA.
[Ti] Título:Assessing the implications of contradictory farm exposure data in an aging rural population.
[So] Source:J Agromedicine;19(3):258-67, 2014.
[Is] ISSN:1545-0813
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Occupational exposure to agriculture can be measured in a variety of ways, including a simple yes/no classification, as well as continuous measures, such as years in farming. Regardless of the exposure measure, the possibility of mismeasurement exists. This can be the result of memory decay, differential interpretation, and overly broad definitions of farming. Data from a 20-year longitudinal study were used to measure the extent of this misclassification, and also to compare results obtained from yes/no measures (ever having farmed and current farmer) versus a more refined measure (years of farming). There were 1,811 households in a rural seven-county region of central New York responding to the survey. All subjects were ≥50 as of 2009. The subjects' 2009 responses relating to agricultural exposure were validated against those given in 1989 and 1999. Subjects giving contradictory responses were contacted for clarification. Of the 445 subjects indicating any kind of agricultural exposure, 186 (41.8%) provided contradictory information. Correction of these led to a lower estimate of farming prevalence, but an increase in the mean years of farming. Contradictory responses were more common for females, subjects with partners, and those with better financial situations. For both the corrected and uncorrected data, ever farming, current farming, and years of farming were all strongly related to both farmer's lung and farm machinery injury. Contradictory information is commonly encountered when measuring agricultural exposure. However, when studying measures that are strongly related to agriculture, the extra effort devoted to clarifying these contradictions may be unnecessary. For outcomes where these relationships are more subtle, correction may be more important.
[Mh] Termos MeSH primário: Doenças dos Trabalhadores Agrícolas/epidemiologia
Agricultura
Exposição Ocupacional/análise
População Rural
[Mh] Termos MeSH secundário: Acidentes de Trabalho/estatística & dados numéricos
Idoso
Envelhecimento
Doenças dos Trabalhadores Agrícolas/etiologia
Características da Família
Pulmão de Fazendeiro/etiologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Estudos Longitudinais
Masculino
Meia-Idade
New York
Curva ROC
Fatores de Risco
Saúde da População Rural
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140625
[Lr] Data última revisão:
140625
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140625
[St] Status:MEDLINE
[do] DOI:10.1080/1059924X.2014.916640


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[PMID]:24370311
[Au] Autor:Xu H; Wu K; Duan DJ
[Ti] Título:[A case report of farmer's lung].
[So] Source:Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi;31(11):874, 2013 Nov.
[Is] ISSN:1001-9391
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Pulmão de Fazendeiro
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1404
[Cu] Atualização por classe:131227
[Lr] Data última revisão:
131227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131228
[St] Status:MEDLINE


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[PMID]:24168036
[Au] Autor:Viegas S; Mateus V; Almeida-Silva M; Carolino E; Viegas C
[Ad] Endereço:a Environmental Health RG, Lisbon School of Health Technology , Polytechnique Institute of Lisbon , Lisboa , Portugal.
[Ti] Título:Occupational exposure to particulate matter and respiratory symptoms in Portuguese swine barn workers.
[So] Source:J Toxicol Environ Health A;76(17):1007-14, 2013.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Certain environmental conditions in animal and plant production have been associated with increased frequency in respiratory illnesses, including asthma, chronic bronchitis, and hypersensitivity pneumonitis, in farmers occupationally exposed in swine production. The aim of this study was to characterize particulate matter (PM) contamination in seven Portuguese swine farms and determine the existence of clinical symptoms associated with asthma and other allergy diseases, utilizing the European Community Respiratory Health Survey questionnaire. Environmental assessments were performed with portable direct-reading equipment, and PM contamination including five different sizes (PM0.5, PM1.0, PM2.5, PM5.0, PM10) was determined. The distribution of particle size showed the same trend in all swine farms, with high concentrations of particles with PM5 and PM10. Results from the questionnaire indicated a trend such that subjects with diagnosis of asthma were exposed to higher concentrations of PM with larger size (PM2.5, PM5, and PM10) while subjects with sneezing, runny nose, or stuffy nose without a cold or flu were exposed to higher concentrations of PM with smaller size (PM0.5 and PM1). Data indicate that inhalation of PM in swine farm workers is associated with increased frequency of respiratory illnesses.
[Mh] Termos MeSH primário: Pulmão de Fazendeiro/etiologia
Exposição Ocupacional/efeitos adversos
Material Particulado/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Animais
Asma/epidemiologia
Asma/etiologia
Pulmão de Fazendeiro/epidemiologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Exposição Ocupacional/estatística & dados numéricos
Portugal/epidemiologia
Prevalência
Fatores Sexuais
Inquéritos e Questionários
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Particulate Matter)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131031
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2013.831720



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