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[PMID]:28430556
[Au] Autor:Halldin CN; Blackley DJ; Petsonk EL; Laney AS
[Ad] Endereço:From the Surveillance Branch, Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Mail Stop HG900.2, Morgantown, WV 26505-2888.
[Ti] Título:Pneumoconioses Radiographs in a Large Population of U.S. Coal Workers: Variability in A Reader and B Reader Classifications by Using the International Labour Office Classification.
[So] Source:Radiology;284(3):870-876, 2017 Sep.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To assess the level of concordance between chest radiographic classifications of A and B Readers in a national surveillance program offered to U.S. coal miners over an approximate 36-year period. Materials and Methods The National Institute for Occupational Safety and Health (NIOSH) Coal Workers' Health Surveillance Program (CWHSP) is a surveillance program with nonresearch designation and is exempt from Human Subjects Review Board approval (11-DRDS-NR03). Thirty-six years of data (1979-2015) from the CWHSP were analyzed, which included all conventional screen-film radiographs with a classification by at least one A Reader and one B Reader. Agreement was assessed by using κ statistics; prevalence ratios were used to describe differences between A and B Reader determinations of image technical quality, small opacity profusion, and presence of large opacities and pleural abnormalities. Results The analysis included 79 185 matched A and B Reader chest radiograph classifications. A majority of both A and B Readers were radiologists (74.2% [213 of 287] vs 64.7% [22 of 34]; P = .04). A and B Readers had minimal agreement on technical image quality (κ = 0.0796; 95% confidence interval [CI]: 0.07, 0.08) and the distribution of small opacity profusion (subcategory κ, 0.2352; 95% CI: 0.22, 0.25). A Readers classified more images as "good" quality (prevalence ratio, 1.38; 95% CI: 1.35, 1.41) and identified more pneumoconiosis (prevalence ratio, 1.22; 95% CI: 1.20, 1.23). Conclusion A Readers classified substantially more radiographs with evidence of pneumoconiosis and classified higher small opacity profusion compared with B Readers. These observations reinforce the importance of multiple classifications by readers who have demonstrated ongoing competence in the International Labour Office classification system to ensure accurate radiographic classifications. RSNA, 2017.
[Mh] Termos MeSH primário: Doenças Profissionais/diagnóstico por imagem
Saúde do Trabalhador/normas
Pneumoconiose/diagnóstico por imagem
Radiografia Torácica/classificação
[Mh] Termos MeSH secundário: Indústria do Carvão Mineral
Seres Humanos
Variações Dependentes do Observador
Reprodutibilidade dos Testes
Estados Unidos
United States Occupational Safety and Health Administration/organização & administração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170917
[Lr] Data última revisão:
170917
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017162437


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[PMID]:28139521
[Au] Autor:Deng CW; Zhang XX; Lin JH; Huang LF; Qu YL; Bai C
[Ad] Endereço:Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai 200433; Department of Cell Biology and Stem Cell Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
[Ti] Título:Association between Genetic Variants of Transforming Growth Factor-ß1 and Susceptibility of Pneumoconiosis: A Meta-analysis.
[So] Source:Chin Med J (Engl);130(3):357-364, 2017 02 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Transforming growth factor-beta 1 (TGF-ß1) and gene variants have been extensively studied in various human diseases. For example, TGF-ß1 polymorphisms were associated with fibrosis and pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-ß1 -509 C>T [rs1800469], +869 T>C [rs1800470], and +915 G>C [rs1800471] polymorphisms and pneumoconiosis. METHODS: A comprehensive literature search was conducted through searching in PubMed, Embase, the Chinese Biomedical Database, and the Wei Pu (Chinese) Database by the end of April 2016. Eleven publications with 21 studies were included in this meta-analysis, covering a total of 4333 patients with pneumoconiosis and 3478 controls. Study quality was assessed, and heterogeneity and publication bias were measured. All statistical analyses were performed using STATA version 12.0 (StataCorp, College Station, TX, USA) software. RESULTS: The data showed significant associations between TGF-ß1 -509 C>T polymorphism and the risk of pneumoconiosis development (T vs. C, odds ratio [OR] = 1.35, 95% confidence interval [CI]: 1.00-1.81, P = 0.046); between TGF-ß1 +915 G>C polymorphism and the pneumoconiosis risk (C vs. G, OR = 1.69, 95% CI: 1.19-2.40, P = 0.004; CG vs. GG, OR = 1.79, 95% CI: 1.23-2.60, P = 0.002; CC+CG vs. GG, OR = 1.80, 95% CI: 1.24-2.61, P = 0.002). In addition, the subgroup analysis of ethnicity versus pneumoconiosis types indicated a significant association of silicosis among Asian populations but not that of coal workers' pneumoconiosis in Caucasian populations. In contrast, no significant association was exhibited between TGF-ß1 +869 T>C polymorphism and risk of pneumoconiosis. CONCLUSION: The polymorphisms of both TGF-ß1 -509 C>T and +915 G>C are associated with increased risk of pneumoconiosis.
[Mh] Termos MeSH primário: Pneumoconiose/genética
Polimorfismo Genético/genética
Fator de Crescimento Transformador beta1/genética
[Mh] Termos MeSH secundário: Grupo com Ancestrais do Continente Asiático
Grupo com Ancestrais do Continente Europeu
Predisposição Genética para Doença/genética
Genótipo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS
[Nm] Nome de substância:
0 (Transforming Growth Factor beta1)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.198917


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[PMID]:27980247
[Au] Autor:Jp NA; Imanaka M; Suganuma N
[Ad] Endereço:Department of Environmental Medicine, Kochi Medical School, Kochi University.
[Ti] Título:Japanese workplace health management in pneumoconiosis prevention.
[So] Source:J Occup Health;59(2):91-103, 2017 Mar 28.
[Is] ISSN:1348-9585
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The Japanese government established the Pneumoconiosis Law in 1960 to protect health and promote the welfare of workers engaged in dust-exposed works. This article describes Japanese practice in workplace health management as regulated by the Pneumoconiosis Law to reduce pneumoconiosis in Japan. METHODS: We collected information addressing pneumoconiosis and the health care of dust-exposed workers. We included all types of scientific papers found through a PubMed search as well as official reports, guidelines, and relevant laws published by the Ministry of Health, Labour and Welfare (MHLW) of Japan and other academic institutions. RESULTS: In the past, pneumoconiosis has been a major cause of mortality and morbidity for Japanese workers engaged in dust-exposed work. The Pneumoconiosis Law introduced a system of pneumoconiosis health examination and health supervision to protect workers' health. According to the periodic pneumoconiosis health examination reports in Japan, the prevalence of pneumoconiosis fell from the highest reported figure of 17.4% in 1982, where 265,720 examinations were conducted, to 1% in 2013 in which 243,740 workers were examined. The number of new cases of pneumoconiosis dropped from 6,842 cases in 1980 to 227 cases in 2013. One hundred and seventy two workers were diagnosed as having pneumoconiosis complications in 1980; however, the number fell to five in 2013. CONCLUSION: After reaching its peak in the 1980s, pneumoconiosis and its complications fell each year. The achievement of Japanese pneumoconiosis prevention can be credited to a comprehensive provision for worker health, regulated by a thorough legal framework.
[Mh] Termos MeSH primário: Exposição Ocupacional/prevenção & controle
Pneumoconiose/diagnóstico
Pneumoconiose/prevenção & controle
Gestão da Segurança
[Mh] Termos MeSH secundário: Poeira
Diagnóstico Precoce
Seres Humanos
Japão/epidemiologia
Saúde do Trabalhador/legislação & jurisprudência
Pneumoconiose/epidemiologia
Pneumoconiose/etiologia
Gestão da Segurança/legislação & jurisprudência
Gestão da Segurança/métodos
Gestão da Segurança/normas
Espirometria
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Dust)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.1539/joh.16-0031-RA


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[PMID]:27816911
[Au] Autor:Reynolds CJ; MacNeill SJ; Williams J; Hodges NG; Campbell MJ; Newman Taylor AJ; Cullinan P
[Ad] Endereço:National Heart and Lung Institute, Imperial College London, London SW3 6LR, UK, carl.reynolds@imperial.ac.uk.
[Ti] Título:Chronic obstructive pulmonary disease in Welsh slate miners.
[So] Source:Occup Med (Lond);67(1):20-25, 2017 Jan.
[Is] ISSN:1471-8405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Exposure to respirable crystalline silica (RCS) causes emphysema, airflow limitation and chronic obstructive pulmonary disease (COPD). Slate miners are exposed to slate dust containing RCS but their COPD risk has not previously been studied. AIMS: To study the cumulative effect of mining on lung function and risk of COPD in a cohort of Welsh slate miners and whether these were independent of smoking and pneumoconiosis. METHODS: The study was based on a secondary analysis of Medical Research Council (MRC) survey data. COPD was defined as forced expiratory volume in 1 s/forced vital capacity (FEV /FVC) ratio <0.7. We created multivariable models to assess the association between mining and lung function after adjusting for age and smoking status. We used linear regression models for FEV and FVC and logistic regression for COPD. RESULTS: In the original MRC study, 1255 men participated (726 slate miners, 529 unexposed non-miners). COPD was significantly more common in miners (n = 213, 33%) than non-miners (n = 120, 26%), P < 0.05. There was no statistically significant difference in risk of COPD between miners and non-miners when analysis was limited to non-smokers or those without radiographic evidence of pneumoconiosis. After adjustment for smoking, slate mining was associated with a reduction in %predicted FEV [ß coefficient = -3.97, 95% confidence interval (CI) -6.65, -1.29] and FVC (ß coefficient = -2.32, 95% CI -4.31, -0.33) and increased risk of COPD (odds ratio: 1.38, 95% CI 1.06, 1.81). CONCLUSIONS: Slate mining may reduce lung function and increase the incidence of COPD independently of smoking and pneumoconiosis.
[Mh] Termos MeSH primário: Mineração/recursos humanos
Exposição Ocupacional/efeitos adversos
Doença Pulmonar Obstrutiva Crônica/epidemiologia
Dióxido de Silício/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Volume Expiratório Forçado
Seres Humanos
Masculino
Meia-Idade
Mineração/estatística & dados numéricos
Exposição Ocupacional/estatística & dados numéricos
Pneumoconiose/diagnóstico
Pneumoconiose/epidemiologia
Pneumoconiose/etiologia
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Radiografia Torácica/estatística & dados numéricos
Fumar/efeitos adversos
Fumar/epidemiologia
Inquéritos e Questionários
Tórax/anormalidades
Capacidade Vital
País de Gales/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE
[do] DOI:10.1093/occmed/kqw147


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[PMID]:28393716
[Au] Autor:Alici NS; Çimrin A; Coskun Beyan A
[Ad] Endereço:Department of Chest Diseases, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey. safak.alici@hotmail.com.
[Ti] Título:Pneumoconiosis in different sectors and their differences in Turkey.
[Ti] Título:Türkiye'de sektörlere göre pnömokonyoz ve farkli özellikleri..
[So] Source:Tuberk Toraks;64(4):275-282, 2016 Dec.
[Is] ISSN:0494-1373
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:Introduction: Pneumoconiosis which is one of the ancient diseases, still affects many workers throughout the world despite "existing" control programs. We add data from a single center reviewing risk factors for pneumoconiosis; evaluate functional and radiological findings in different sectors. Materials and Methods: We reviewed medical records of patients diagnosed with pneumoconiosis who were admitted to our center between the years 2013 and 2015. Several personal and occupational features, together with functional and radiologic data, were collected. Result: 60 were young males. Twenty-four of the cases (39.3%) worked at dental technician, 24 cases (39.3%) were ceramic workers, 5 cases (8.2%) were sandblasters, 2 cases (3.3%) were welders, 3 cases (4.9%) were miners, and 3 cases (4.9%) were marble cutters. The sectors in which the exposure started at the earliest ages were dental technicians and sandblasters, while the shortest working time was in sandblasting. The dental technicians were younger than the ceramic workers at the age of diagnosis (Kruskall-Wallis p= 0.003). The exposure time of the sandblasters was significantly shorter, especially than the ceramic workers (Kruskall-Wallis p= 0.002). The cases have been referred to us with pneumoconiosis suspicion based on the radiographic findings in the PA chest roentgenogram performed during the periodic examinations at their work place; but unlike other studies, in our study, following the HRCT assessment, cases which did not present any visible pathology in the re-evaluation of their PA chest roentgenogram, but had HRCT findings have been diagnosed as pneumoconiosis. Among the 44 cases in which micro-nodules had been detected at their HRCT, 15 of them had been previously classified as profusion of small opacities 0/1 according to their PA chest roentgenogram findings. It has been seen that the HRCT findings differ among sectors. Ceramics workers and sandblasters had significantly more micro-nodules, while dental technicians had significantly more mediastinal lymphadenopathies (Chi square, p= 0.004 and p= 0.007 respectively). When the relationship between the existence of big opacities and complaints was studied, statistically significant weight loss was detected in cases which had C opacities (chi square p= 0.01). Statistically significant FEV1 decrease was observed in cases which had weight loss (independent samples t-test p= 0.046). It has been observed that when the profusion of small opacities increased, while there was no statistically significant functional status change in non-smokers, a significant functional impairment was observed in smokers. Conclusions: Pneumoconiosis still exists in Turkey. Even a short exposure time as 2 years can cause pneumoconiosis. Workers in different sectors had different functional, radiological properties and smoking can affect the diseases' course. There are serious limitations related to the surveillance of both the workplace environment and the employees' health in Turkey. Without institutional preventive measures, personal protection and surveillance examinations, occupational hazards will continue to cause premature deaths. Pneumoconiosis in different sectors is a prototype of uncontrolled industry in the developing world.
[Mh] Termos MeSH primário: Doenças Profissionais/epidemiologia
Pneumoconiose/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Estudos Transversais
Técnicos em Prótese Dentária
Feminino
Seres Humanos
Masculino
Meia-Idade
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Pneumoconiose/etiologia
Pneumoconiose/prevenção & controle
Radiografia Torácica
Fatores de Risco
Fumar
Turquia/epidemiologia
Local de Trabalho
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE


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[PMID]:28005090
[Au] Autor:Muszynska-Graca M; Dabkowska B; Brewczynski PZ
[Ad] Endereço:Instytut Medycyny Pracy i Zdrowia Srodowiskowego / Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland (Zaklad Zdrowia Srodowiskowego i Epidemiologii / Department of Environmental Health and Epidemiology). m.muszynska@imp.sosnowiec.pl.
[Ti] Título:[Guidelines for the use of the International Classification of Radiographs of Pneumoconioses of the International Labour Office (ILO): Substantial changes in the currrent edition].
[Ti] Título:Wytyczne stosowania Miedzynarodowej Klasyfikacji Radiogramów Pylic Pluc Miedzynarodowego Biura Pracy (ILO) ­ istotne zmiany w obecnie obowiazujacej edycji..
[So] Source:Med Pr;67(6):833-837, 2016 Dec 22.
[Is] ISSN:0465-5893
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:The International Classification of Radiographs of Pneumoconioses is the scheme worked out by the International Labour Office in Geneva (ILO), to register radiographic chest abnormalities in a well-ordered, reproducible and comparable way. It is used for diagnosing abnormalities caused by dust exposure. Guidelines for the use of the ILO International Classification of Radiographs of Pneumoconioses contain detailed information and recommendations on how to use the classification, as well as how the chest X-ray examination should be performed and recorded. To facilitate the diagnosis of observed abnormalities the classification is completed by the set of standard radiograms illustrating typical irregularities referring to lungs and pleura, included in the classification. The article presents the key information on classification and the most important amendments adopted in the 2000 and 2011 ILO guidelines revisions. These changes refer to radiographs quality assessment, the way of presenting abnormalities registered in standard radiographs (QUAD set, digital images) and registration of failures not related to dust exposure. Particularly important complements result from the development of radiological imaging techniques. They are concerned about the classification of radiographic images of the chest recorded digitally. Med Pr 2016;67(6):833-837.
[Mh] Termos MeSH primário: Classificação Internacional de Doenças/normas
Doenças Profissionais/diagnóstico por imagem
Medicina do Trabalho/normas
Pneumoconiose/diagnóstico por imagem
Intensificação de Imagem Radiográfica/normas
[Mh] Termos MeSH secundário: Seres Humanos
Doenças Profissionais/classificação
Pneumoconiose/classificação
Guias de Prática Clínica como Assunto
Radiologia/normas
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:GUIDELINE; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE


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[PMID]:27755862
[Au] Autor:Altinöz H; Çelikkalkan C; Horasan GD; Hamsioglu F; Cengiz N; Orbay H
[Ad] Endereço:Pulmonary Division, Faculty of Medicine, Acibadem University, Istanbul.
[Ti] Título:Socio-Demographic and Clinical Characteristics of Turkish Workers with Pneumoconiosis.
[So] Source:Cent Eur J Public Health;24(3):231-233, 2016 Sep.
[Is] ISSN:1210-7778
[Cp] País de publicação:Czech Republic
[La] Idioma:eng
[Ab] Resumo:AIM: Pneumoconiosis is caused by inhaling dust. The aim of the study was to analyze 208 cases of workers' pneumoconiosis. METHOD: Patients' files were used for the descriptive study. RESULTS: All patients were male aged 38.82±13 years. The most important symptom was breathlessness. Patients were denim sandblasters (50.5%), dental technicians (12%), coal miners (6.7%), and others. The mean exposure time before pneumoconiosis occurred was shorter in denim sandblasters and teflon kitchenware producers compared to other occupations (5.4±4.2 and 4.5±3.3 years, respectively). Profusion (76.5%) was more than 1/2 by the International Labour Organization (ILO) classification. Pulmonary function tests were negatively correlated with profusion. CONCLUSION: Denim sandblasters and teflon kitchenware producers have less exposure time before pneumoconiosis occurs and they become symptomatic earlier. As Turkish workers suffering from pneumoconiosis are younger, measures to prevent pneumoconiosis must be the priority of the healthcare authorities.
[Mh] Termos MeSH primário: Exposição Ocupacional/efeitos adversos
Ocupações
Pneumoconiose/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Poeira
Feminino
Seres Humanos
Masculino
Politetrafluoretileno
Testes de Função Respiratória
Fatores de Risco
Fatores Socioeconômicos
Turquia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dust); 9002-84-0 (Polytetrafluoroethylene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27682668
[Au] Autor:Yang LH; Xiao YL; Chen BL; Tang HQ; Lvqiu SJ; Xia GH
[Ad] Endereço:Hunan Prevention and Treatment Institute of Occupational Diseases, Changsha 410007, China.
[Ti] Título:[An investigation of prevalence of occupational diseases and treatment implementation in migrant workers in Hunan, China].
[So] Source:Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi;34(8):598-600, 2016 Aug 20.
[Is] ISSN:1001-9391
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the prevalence of occupational diseases and treatment implementation in migrant workers in Hunan, China, and to provide a scientific basis for related departments to develop preventive and treatment measures and social security system for migrant workers. A retrospective investigation was performed in 2015 to collect the information of occupational diseases in migrant workers, and age, type of work, type of occupational disease, and implementation of employment injury insurance for occupation diseases were analyzed. The migrant workers with occupational diseases accounted for 50.43% (11 280/22 368) of all patients with occupational diseases in Hunan, among whom 99.4% (11 212/11 280) were male workers. The mean age of migrant workers with occupational diseases was 55 years. The types of occupational diseases involved 6 categories such as occupational pneumoconiosis and occupational skin diseases, totaling 42 legal occupational diseases; 98.31% of all migrant workers (11 089/11 280) had occupational pneumoconiosis. The main types of work were underground coal miners (62.42%) , heading drivers (29.79%) , and haulage workers (2.20%) in coal mines and non-coal mines. A total of 27.25% migrant workers with occupational diseases (2 072/7 605) enjoyed employment injury insurance, and 20.84% (1 585/7 605) did not receive any medical or life compensations. The occupational diseases in migrant workers in Hunan are mainly pneumoconiosis, and a large proportion of those with occupational diseases do not enjoy implementation of treatment. Coal mines and non-coal mines are the high-risk areas for occupational diseases in migrant workers and should be the focus of prevention and control.
[Mh] Termos MeSH primário: Doenças Profissionais/epidemiologia
Doenças Profissionais/prevenção & controle
Migrantes/estatística & dados numéricos
[Mh] Termos MeSH secundário: China
Minas de Carvão
Emprego
Seres Humanos
Masculino
Pneumoconiose
Prevalência
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1001-9391.2016.08.010


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[PMID]:27682490
[Au] Autor:Liu YT; Zeng Q; Li SX; Yang DY; Xing WY; Feng LM; Zhang M
[Ad] Endereço:Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China.
[Ti] Título:[The expression of serum miRNAs in pneumoconiosis complicated with pulmonary tuberculosis patients].
[So] Source:Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi;34(7):525-527, 2016 Jul 20.
[Is] ISSN:1001-9391
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To inquiry the changes of serum miRNAs expression in pneumoconiosis complicated with pulmonary tuberculosis patients. The study subjects (all subjects are male) were divided into three groups: Ⅰstage pneumoconiosis (38 cases) 、Pneumoconiosis complicated with pulmonary tuberculosis (12 cases) and healthy control (40cases) . The first two groups come from Tianjin worker's sanatorium and healthy control group came from a Hospital Health Screening Center. RT-qPCR was used to detect the expression levels of miR-21, miR-200c, miR-16, miR-204, miR-206, miR-155, let-7g, miR-30b, miR-192, miR-29a in serum. Compared with the healthy control group, the expression levels of miR-204, miR-206, miR-21, miR-16, miR-29a, miR-155, miR-200c in other two groups are different ( <0.05) ; Compared with the Ⅰstage pneumoconiosis, the expression levels of miR-155 is significantly higher ( <0.05) and miR-29a is significantly lower ( <0.05) . Compared with the Ⅰstage pneumoconiosis, the expression levels of miR-155 and miR-29a are significantly different, suggesting that these two miRNAs may play a important role in the process of pneumoconiosis complicated with pulmonary tuberculosis.
[Mh] Termos MeSH primário: MicroRNAs/metabolismo
Pneumoconiose/complicações
Tuberculose Pulmonar/complicações
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Soro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MIRN155 microRNA, human); 0 (MIRN29 microRNA, human); 0 (MicroRNAs)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1001-9391.2016.07.012


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[PMID]:27682487
[Au] Autor:Yu B; Ding BM; Fan CH; Liu QD; Ding L; Wang BS; Wang J; Zhang HD; Zhang F
[Ad] Endereço:The Center for Disease Control and Prevention of Jiangsu Province, Nanjing 210028, China.
[Ti] Título:[Health status of dust-exposed workers in a precision casting enterprise].
[So] Source:Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi;34(7):517-519, 2016 Jul 20.
[Is] ISSN:1001-9391
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To investigate the health status of workers exposed to zircon sand and silica dust in a precision casting enterprise, and to provide a basis for the development of prevention and control measures. Occupational health examination, questionnaire survey, and field investigation of occupational health were performed for 176 male workers (18 workers in the zirconium dust exposure group, 109 in the non-zirconium dust exposure group, and 49 in the non-dust exposure group) in a precision casting enterprise, and a statistical analysis was performed for the data obtained. Dust and noise were major hazard factors for occupational diseases in this enterprise. The abnormal rate of physical examination was 71.02%. Compared with the non-zirconium dust exposure group, the zirconium dust exposure group had significantly higher detection rates of restrictive ventilatory dysfunction, increased immunoglobulin IgE, increased alanine aminotransferase, and increased alkaline phosphatase (ALP) ( <0.05) ; compared with the non-dust exposure group, the zirconium dust exposure group had a significantly higher detection rate of increased ALP ( <0.05) . Of all workers, 15 were found to have pneumoconiosis-like changes (11 had pneumoconiosis and 4 needed observation) , among whom 4 were in the zirconium dust exposure group (3 had pneumoconiosis and 1 needed observation) and 11 were in the non-zirconium dust exposure group (8 had pneumoconiosis and 3 needed observation) . The detection rate of pneumoconiosis-like changes showed no significant differences between the two groups (20.22% vs 10.09%) . There was a severe dust hazard in this enterprise. Inhalation of dust containing zirconium is associated with respiratory system injury, especially the development of pneumoconiosis, and it may also cause immune dysfunction and liver impairment.
[Mh] Termos MeSH primário: Poeira
Exposição por Inalação/efeitos adversos
Doenças Profissionais
[Mh] Termos MeSH secundário: Nível de Saúde
Seres Humanos
Peptídeos e Proteínas de Sinalização Intracelular
Pneumopatias
Masculino
Pneumoconiose/prevenção & controle
Estudos Retrospectivos
Silicatos/efeitos adversos
Dióxido de Silício/efeitos adversos
Inquéritos e Questionários
Zircônio/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CD3EAP protein, human); 0 (Dust); 0 (Intracellular Signaling Peptides and Proteins); 0 (Silicates); 4SY8H89134 (zircon); 7631-86-9 (Silicon Dioxide); C6V6S92N3C (Zirconium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1001-9391.2016.07.009



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