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  1 / 18023 MEDLINE  
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[PMID]:28460631
[Au] Autor:Yu D; Chen T; Cai Y; Zhao Z; Simmons D
[Ad] Endereço:Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
[Ti] Título:Association between pulmonary function and renal function: findings from China and Australia.
[So] Source:BMC Nephrol;18(1):143, 2017 May 01.
[Is] ISSN:1471-2369
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The relationship between obstructive lung function and impaired renal function is unclear. This study investigated the dose-response relationship between obstructive lung function and impaired renal function. METHODS: Two independent cross-sectional studies with representative sampling were applied. 1454 adults from rural Victoria, Australia (1298 with normal renal function, 156 with impaired renal function) and 5824 adults from Nanjing, China (4313 with normal renal function, 1511 with impaired renal function). Pulmonary function measurements included forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Estimated glomerular filtration rate (eGFR), and impaired renal function marked by eGFR <60 mL/min/1.73m were used as outcome. RESULTS: eGFR increased linearly with FEV1 in Chinese participants and with FVC in Australians. A non-linear relationship with peaked eGFR was found for FEV1 at 2.65 L among Australians and for FVC at 2.78 L among Chinese participants, respectively. A non-linear relationship with peaked eGFR was found for the predicted percentage value of forced expiratory volume in 1 s (PFEV1) at 81-82% and for the predicted percentage value of forced vital capacity (PFVC) at 83-84% among both Chinese and Australian participants, respectively. The non-linear dose-response relationships between lung capacity measurements (both for FEV1 and FVC) and risk of impaired renal function were consistently identified in both Chinese and Australian participants. An increased risk of impaired renal function was found below 3.05 L both for FEV1 and FVC, respectively. The non-linear relationship between PFEV and PVC and the risk of impaired renal function were consistently identified in both Chinese and Australian participants. An increased risk of impaired renal function was found below 76-77% for PFEV1 and 79-80% for PFVC, respectively. CONCLUSIONS: In both Australian and Chinese populations, the risk of impaired renal function increased both with FEV1 and FVC below 3.05 L, with PFEV1 below 76-77% or with PFVC below 79-80%, respectively. Obstructive lung function was associated with increased risk of reduced renal function. The screen for impaired renal function in patients with obstructive lung disease might be useful to ensure there was no impaired renal function before the commencement of potentially nephrotoxic medication where indicated (eg diuretics).
[Mh] Termos MeSH primário: Nefropatias/diagnóstico
Nefropatias/epidemiologia
Testes de Função Renal/estatística & dados numéricos
Pneumopatias Obstrutivas/diagnóstico
Pneumopatias Obstrutivas/epidemiologia
Testes de Função Respiratória/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
China/epidemiologia
Comorbidade
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Fatores de Risco
Sensibilidade e Especificidade
Vitória/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1186/s12882-017-0565-y


  2 / 18023 MEDLINE  
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[PMID]:28471492
[Au] Autor:Morrison L; Innes S
[Ad] Endereço:West of Scotland Adult CF Unit, Queen Elizabeth University Hospital (The Southern General Hospital), 1345 Govan Road, Glasgow, UK, G51 4TF.
[Ti] Título:Oscillating devices for airway clearance in people with cystic fibrosis.
[So] Source:Cochrane Database Syst Rev;5:CD006842, 2017 05 04.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chest physiotherapy is widely prescribed to assist the clearance of airway secretions in people with cystic fibrosis. Oscillating devices generate intra- or extra-thoracic oscillations orally or external to the chest wall. Internally they create variable resistances within the airways, generating controlled oscillating positive pressure which mobilises mucus. Extra-thoracic oscillations are generated by forces outside the respiratory system, e.g. high frequency chest wall oscillation. This is an update of a previously published review. OBJECTIVES: To identify whether oscillatory devices, oral or chest wall, are effective for mucociliary clearance and whether they are equivalent or superior to other forms of airway clearance in the successful management of secretions in people with cystic fibrosis. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches and hand searches of relevant journals and abstract books of conference proceedings. Latest search of the Cystic Fibrosis Trials Register: 27 April 2017.In addition we searched the trials databases ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform. Latest search of trials databases: 26 April 2017. SELECTION CRITERIA: Randomised controlled studies and controlled clinical studies of oscillating devices compared with any other form of physiotherapy in people with cystic fibrosis. Single-treatment interventions (therapy technique used only once in the comparison) were excluded. DATA COLLECTION AND ANALYSIS: Two authors independently applied the inclusion criteria to publications and assessed the quality of the included studies. MAIN RESULTS: The searches identified 76 studies (302 references); 35 studies (total of 1138 participants) met the inclusion criteria. Studies varied in duration from up to one week to one year; 20 of the studies were cross-over in design. The studies also varied in type of intervention and the outcomes measured, data were not published in sufficient detail in most of these studies, so meta-analysis was limited. Few studies were considered to have a low risk of bias in any domain. It is not possible to blind participants and clinicians to physiotherapy interventions, but 11 studies did blind the outcome assessors.Forced expiratory volume in one second was the most frequently measured outcome. One long-term study (seven months) compared oscillatory devices with either conventional physiotherapy or breathing techniques and found statistically significant differences in some lung function parameters in favour of oscillating devices. One study identified an increase in frequency of exacerbations requiring antibiotics whilst using high frequency chest wall oscillation when compared to positive expiratory pressure. There were some small but significant changes in secondary outcome variables such as sputum volume or weight, but not wholly in favour of oscillating devices. Participant satisfaction was reported in 15 studies but this was not specifically in favour of an oscillating device, as some participants preferred breathing techniques or techniques used prior to the study interventions. The results for the remaining outcome measures were not examined or reported in sufficient detail to provide any high level evidence. AUTHORS' CONCLUSIONS: There was no clear evidence that oscillation was a more or less effective intervention overall than other forms of physiotherapy; furthermore there was no evidence that one device is superior to another. The findings from one study showing an increase in frequency of exacerbations requiring antibiotics whilst using an oscillating device compared to positive expiratory pressure may have significant resource implications. More adequately-powered long-term randomised controlled trials are necessary and outcomes measured should include frequency of exacerbations, individual preference, adherence to therapy and general satisfaction with treatment. Increased adherence to therapy may then lead to improvements in other parameters, such as exercise tolerance and respiratory function. Additional evidence is needed to evaluate whether oscillating devices combined with other forms of airway clearance is efficacious in people with cystic fibrosis.There may also be a requirement to consider the cost implication of devices over other forms of equally advantageous airway clearance techniques. Using the GRADE method to assess the quality of the evidence, we judged this to be low or very low quality, which suggests that further research is very likely to have an impact on confidence in any estimate of effect generated by future interventions.
[Mh] Termos MeSH primário: Oscilação da Parede Torácica/instrumentação
Fibrose Cística/complicações
Pneumopatias Obstrutivas/terapia
Depuração Mucociliar
Muco/secreção
Vibração/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Exercícios Respiratórios
Criança
Fibrose Cística/fisiopatologia
Progressão da Doença
Fluxo Expiratório Forçado
Volume Expiratório Forçado
Seres Humanos
Pneumopatias Obstrutivas/etiologia
Meia-Idade
Satisfação do Paciente
Ensaios Clínicos Controlados Aleatórios como Assunto
Escarro/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD006842.pub4


  3 / 18023 MEDLINE  
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[PMID]:28981500
[Au] Autor:d'Hooghe JNS; Goorsenberg AWM; de Bruin DM; Roelofs JJTH; Annema JT; Bonta PI
[Ad] Endereço:Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
[Ti] Título:Optical coherence tomography for identification and quantification of human airway wall layers.
[So] Source:PLoS One;12(10):e0184145, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based optical coherence tomography (OCT) is a novel imaging technique that combined with bronchoscopy generates highly detailed images of the airway wall. The aim of this study is to identify and quantify human airway wall layers both ex-vivo and in-vivo by OCT and correlate these to histology. METHODS: Patients with lung cancer, prior to lobectomy, underwent bronchoscopy including in-vivo OCT imaging. Ex-vivo OCT imaging was performed in the resected lung lobe after needle insertion for matching with histology. Airway wall layer perimeters and their corresponding areas were assessed by two independent observers. Airway wall layer areas (total wall area, mucosal layer area and submucosal muscular layer area) were calculated. RESULTS: 13 airways of 5 patients were imaged by OCT. Histology was matched with 51 ex-vivo OCT images and 39 in-vivo OCT images. A significant correlation was found between ex-vivo OCT imaging and histology, in-vivo OCT imaging and histology and ex-vivo OCT imaging and in-vivo OCT imaging for all measurements (p < 0.0001 all comparisons). A minimal bias was seen in Bland-Altman analysis. High inter-observer reproducibility with intra-class correlation coefficients all above 0.90 were detected. CONCLUSIONS: OCT is an accurate and reproducible imaging technique for identification and quantification of airway wall layers and can be considered as a promising minimal-invasive imaging technique to identify and quantify airway remodeling in obstructive lung diseases.
[Mh] Termos MeSH primário: Broncoscopia/métodos
Pneumopatias Obstrutivas/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Sistema Respiratório/diagnóstico por imagem
Tomografia de Coerência Óptica/métodos
[Mh] Termos MeSH secundário: Idoso
Remodelação das Vias Aéreas
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171022
[Lr] Data última revisão:
171022
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184145


  4 / 18023 MEDLINE  
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[PMID]:28902919
[Au] Autor:Gupte AN; Wong ML; Msandiwa R; Barnes GL; Golub J; Chaisson RE; Hoffmann CJ; Martinson NA
[Ad] Endereço:Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
[Ti] Título:Factors associated with pulmonary impairment in HIV-infected South African adults.
[So] Source:PLoS One;12(9):e0184530, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: HIV-infected individuals have increased risk of developing obstructive lung disease (OLD). Studies from developed countries report high viral load, low CD4 counts, and anti-retroviral therapy (ART) to be associated with OLD; but these findings may not be generalizable to populations in resource-limited settings. METHODS: We conducted a prospective cohort study of lung function in 730 HIV-infected black South African adults. Pre-bronchodilator spirometry was performed at enrollment and repeated annually for three years. Logistic regression models were used to identify factors associated with OLD, defined as FEV1/FVC<0.70, at enrollment. Excess annual declines in FEV1 and FVC were modelled as the product-term of follow-up time and exposures using random effects regression. RESULTS: Median (IQR) age at enrollment was 36 (32-41) years, 85% were female and 30% ever-smoked with a median (IQR) exposure of 3 (1-6) pack-years. Median (IQR) CD4 count and viral load at enrollment were 372 (261-518) cells/mm3 and 2655 (91-13,548) copies/mL respectively. Overall, 25% were receiving ART at enrollment, 16% of whom reported at least 6 months of ART receipt. OLD was found in 35 (5%) at enrollment. Increasing age (aOR = 2.08 per 10-years [95%CI 1.22-3.57], p = 0.007), current smoking (aOR = 3.55 [95%CI 1.20-10.53], p = 0.02), and CRP (aOR = 1.01 per unit-increase [95%CI 1.00-1.03], p = 0.04) were significantly associated with OLD at enrollment; while increasing CD4 count (aOR = 1.02 per-100 cells/mm3 [95%CI 0.85-1.22], p = 0.82), viral load (aOR = 0.67 per log-increase [95%CI 0.43-1.10], p = 0.12) and receipt of ART (aOR = 0.57 [95%CI 0.18-1.75], p = 0.32) were not. The median (IQR) follow-up time was 18 (12-24) months. Participants with a history of tuberculosis (TB) had a 35 mL (95%CI 2-68, p = 0.03) and 57 mL (95%CI 19-96, p = 0.003) per year excess loss of FEV1 and FVC respectively. CONCLUSION: Prevalent OLD was associated with older age, current smoking and higher CRP levels, but not CD4 counts and ART, in HIV-infected South African adults. Better understanding of the long-term effects of TB, smoking and inflammation on lung function in HIV-infected populations is urgently needed.
[Mh] Termos MeSH primário: Infecções por HIV/complicações
Pneumopatias Obstrutivas/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Antirretrovirais/efeitos adversos
Antirretrovirais/uso terapêutico
Contagem de Linfócito CD4
Estudos de Coortes
Feminino
Seres Humanos
Modelos Logísticos
Pneumopatias Obstrutivas/complicações
Masculino
Fatores de Risco
Fumar
África do Sul
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Retroviral Agents)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184530


  5 / 18023 MEDLINE  
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[PMID]:28810910
[Au] Autor:Wu JS; Lo HY; Li CC; Chen FY; Hsiang CY; Ho TY
[Ad] Endereço:Graduate Institute of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung, 40402, Taiwan.
[Ti] Título:Comprehensive evaluation of gene expression signatures in response to electroacupuncture stimulation at Zusanli (ST36) acupoint by transcriptomic analysis.
[So] Source:BMC Complement Altern Med;17(1):406, 2017 Aug 15.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Electroacupuncture (EA) has been applied to treat and prevent diseases for years. However, molecular events happened in both the acupunctured site and the internal organs after EA stimulation have not been clarified. METHODS: Here we applied transcriptomic analysis to explore the gene expression signatures after EA stimulation. Mice were applied EA stimulation at ST36 for 15 min and nine tissues were collected three hours later for microarray analysis. RESULTS: We found that EA affected the expression of genes not only in the acupunctured site but also in the internal organs. EA commonly affected biological networks involved in cytoskeleton and cell adhesion, and also regulated unique process networks in specific organs, such as γ-aminobutyric acid-ergic neurotransmission in brain and inflammation process in lung. In addition, EA affected the expression of genes related to various diseases, such as neurodegenerative diseases in brain and obstructive pulmonary diseases in lung. CONCLUSIONS: This report applied, for the first time, a global comprehensive genome-wide approach to analyze the gene expression profiling of acupunctured site and internal organs after EA stimulation. The connection between gene expression signatures, biological processes, and diseases might provide a basis for prediction and explanation on the therapeutic potentials of acupuncture in organs.
[Mh] Termos MeSH primário: Pontos de Acupuntura
Eletroacupuntura
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Encéfalo/metabolismo
Feminino
Perfilação da Expressão Gênica
Inflamação
Pulmão/metabolismo
Pneumopatias Obstrutivas
Meridianos
Camundongos Endogâmicos BALB C
Doenças Neurodegenerativas
Transmissão Sináptica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1911-0


  6 / 18023 MEDLINE  
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[PMID]:28796825
[Au] Autor:Shin JM; Kim TH; Haam S; Han K; Byun MK; Chang YS; Kim HJ; Park CH
[Ad] Endereço:Department of Radiology and the Research Institute of Radiological Science, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
[Ti] Título:The repeatability of computed tomography lung volume measurements: Comparisons in healthy subjects, patients with obstructive lung disease, and patients with restrictive lung disease.
[So] Source:PLoS One;12(8):e0182849, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, we examined the repeatability of computed tomography (CT) lung volume measurements in healthy individuals and patients with obstructive and restrictive lung diseases. To do this, we retrospectively enrolled 200 healthy individuals (group 1), 100 patients with obstructive lung disease (group 2), and 100 patients with restrictive lung disease (group 3) who underwent two consecutive chest CT scans within a 1-year period. The CT lung volume was measured using a threshold-based, three-dimensional auto-segmentation technique at a default range from -200 to -1024 HU. The within-subject standard deviation, repeatability coefficient, within-subject coefficient variability, and intraclass correlation coefficient were evaluated. No significant differences were identified between the two consecutive CT lung volume measurements in any of the groups (p> 0.05). The within-subject standard deviations for groups 1, 2, and 3 were 441.1, 387.0, and 288.6, respectively, while the repeatability coefficients were 1222.6, 1072.6, and 800.1, respectively. The within-subject coefficient variabilities for groups 1, 2, and 3 were 0.097, 0.083, and 0.090, respectively, while the intraclass correlation coefficients were 0.818, 0.881, and 0.910, respectively. The two CT lung volume measurements showed excellent agreement in healthy individuals and patients with obstructive or restrictive lung disease. However, the repeatability was lower in healthy individuals than it was in patients with lung diseases.
[Mh] Termos MeSH primário: Pneumopatias/diagnóstico por imagem
Pulmão/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Voluntários Saudáveis
Seres Humanos
Pneumopatias Obstrutivas/diagnóstico por imagem
Medidas de Volume Pulmonar
Masculino
Meia-Idade
Reprodutibilidade dos Testes
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182849


  7 / 18023 MEDLINE  
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[PMID]:28667160
[Au] Autor:Lewis BW; Sultana R; Sharma R; Noël A; Langohr I; Patial S; Penn AL; Saini Y
[Ad] Endereço:Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803.
[Ti] Título:Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease.
[So] Source:J Immunol;199(3):1170-1183, 2017 Aug 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Secondhand smoke (SHS) exposure has been linked to the worsening of ongoing lung diseases. However, whether SHS exposure affects the manifestation and natural history of imminent pediatric muco-obstructive airway diseases such as cystic fibrosis remains unclear. To address these questions, we exposed transgenic ( -Tg ) mice to SHS from postnatal day (PND) 3-21 and lung phenotypes were examined at PND22. Although a majority of filtered air (FA)-exposed -Tg (FA-Tg ) mice successfully cleared spontaneous bacterial infections by PND22, the SHS-exposed -Tg (SHS-Tg ) mice failed to resolve these infections. This defect was associated with suppressed antibacterial defenses, i.e., phagocyte recruitment, IgA secretion, and Muc5b expression. Whereas the FA-Tg mice exhibited marked mucus obstruction and responses, SHS-Tg mice displayed a dramatic suppression of these responses. Mechanistically, downregulated expression of IL-33, a stimulator of type II innate lymphoid cells, in lung epithelial cells was associated with suppression of neutrophil recruitment, IgA secretions, responses, and delayed bacterial clearance in SHS-Tg mice. Cessation of SHS exposure for 21 d restored previously suppressed responses, including phagocyte recruitment, IgA secretion, and mucous cell metaplasia. However, in contrast with FA-Tg mice, the SHS-Tg mice had pronounced epithelial necrosis, alveolar space consolidation, and lymphoid hyperplasia; indicating lagged unfavorable effects of early postnatal SHS exposure in later life. Collectively, our data show that early postnatal SHS exposure reversibly suppresses IL-33 levels in airspaces which, in turn, results in reduced neutrophil recruitment and diminished response. Our data indicate that household smoking may predispose neonates with muco-obstructive lung disease to bacterial exacerbations.
[Mh] Termos MeSH primário: Infecções Bacterianas/imunologia
Pneumopatias Obstrutivas/imunologia
Poluição por Fumaça de Tabaco/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Infecções Bacterianas/fisiopatologia
Carga Bacteriana
Movimento Celular
Fibrose Cística/imunologia
Fibrose Cística/microbiologia
Fibrose Cística/fisiopatologia
Modelos Animais de Doenças
Regulação para Baixo
Células Epiteliais/imunologia
Células Epiteliais/patologia
Canais Epiteliais de Sódio/deficiência
Canais Epiteliais de Sódio/genética
Canais Epiteliais de Sódio/metabolismo
Feminino
Células Caliciformes/patologia
Seres Humanos
Imunoglobulina A/imunologia
Interleucina-33/genética
Interleucina-33/imunologia
Interleucina-33/metabolismo
Pulmão/citologia
Pulmão/imunologia
Pulmão/patologia
Pneumopatias Obstrutivas/fisiopatologia
Camundongos
Camundongos Transgênicos
Mucina-5B
Muco/metabolismo
Neutrófilos/imunologia
Neutrófilos/patologia
Neutrófilos/fisiologia
Transdução de Sinais
Células Th2/imunologia
Células Th2/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Epithelial Sodium Channels); 0 (Il33 protein, mouse); 0 (Immunoglobulin A); 0 (Interleukin-33); 0 (Muc5b protein, mouse); 0 (Mucin-5B); 0 (SCNN1B protein, human); 0 (Tobacco Smoke Pollution)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170702
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700144


  8 / 18023 MEDLINE  
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[PMID]:28632869
[Au] Autor:Gupta A; Yek C; Hendler RS
[Ad] Endereço:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
[Ti] Título:Phenytoin Toxicity.
[So] Source:JAMA;317(23):2445-2446, 2017 Jun 20.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Extubação
Anticonvulsivantes/efeitos adversos
Epilepsia/tratamento farmacológico
Erros de Medicação/efeitos adversos
Fenitoína/efeitos adversos
Gestão de Riscos
Análise de Causa Fundamental
[Mh] Termos MeSH secundário: Anticonvulsivantes/administração & dosagem
Anticonvulsivantes/sangue
Esquema de Medicação
Seres Humanos
Pneumopatias Obstrutivas/sangue
Pneumopatias Obstrutivas/complicações
Masculino
Meia-Idade
Fenitoína/administração & dosagem
Fenitoína/sangue
Insuficiência Respiratória/etiologia
Insuficiência Respiratória/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 6158TKW0C5 (Phenytoin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.6881


  9 / 18023 MEDLINE  
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[PMID]:28476853
[Au] Autor:Akamine T; Toyokawa G; Matsubara T; Kozuma Y; Haratake N; Takamori S; Katsura M; Takada K; Shoji F; Okamoto T; Maehara Y
[Ad] Endereço:Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:Significance of the Preoperative CONUT Score in Predicting Postoperative Disease-free and Overall Survival in Patients with Lung Adenocarcinoma with Obstructive Lung Disease.
[So] Source:Anticancer Res;37(5):2735-2742, 2017 05.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The usefulness of the controlling nutritional status (CONUT) score for preoperative nutritional assessment has been reported in resected colorectal and esophageal cancer, but not in lung cancer with obstructive lung disease. PATIENTS AND METHODS: We retrospectively reviewed 109 patients with adenocarcinoma with obstructive pulmonary disease. We set 1 as the cut-off value for the CONUT score and classified patients into high (≥1) and low (0) CONUT groups. RESULTS: Among 109 patients, 35 (32.1%) had low CONUT scores, and 74 (67.8%) had high CONUT scores. The high-CONUT group was significantly associated with a lower body mass index (p=0.025) and wild-type epidermal growth factor receptor mutation status (p=0.011). A multivariate analysis showed that the CONUT score was independently associated with disease-free and overall survival. CONCLUSION: The results of this study suggest that the CONUT score was an independent prognostic factor for disease-free and overall survival in patients with lung adenocarcinoma with obstructive lung disease.
[Mh] Termos MeSH primário: Adenocarcinoma
Pneumopatias Obstrutivas
Neoplasias Pulmonares
Estado Nutricional
[Mh] Termos MeSH secundário: Adenocarcinoma/sangue
Adenocarcinoma/genética
Adenocarcinoma/patologia
Adenocarcinoma/cirurgia
Idoso
Idoso de 80 Anos ou mais
Índice de Massa Corporal
Antígeno Carcinoembrionário/genética
Colesterol/sangue
Feminino
Seres Humanos
Pneumopatias Obstrutivas/sangue
Pneumopatias Obstrutivas/genética
Pneumopatias Obstrutivas/patologia
Pneumopatias Obstrutivas/cirurgia
Neoplasias Pulmonares/sangue
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/patologia
Neoplasias Pulmonares/cirurgia
Contagem de Linfócitos
Masculino
Meia-Idade
Mutação
Período Pós-Operatório
Período Pré-Operatório
Prognóstico
Receptor do Fator de Crescimento Epidérmico/genética
Albumina Sérica/análise
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinoembryonic Antigen); 0 (Serum Albumin); 97C5T2UQ7J (Cholesterol); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


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[PMID]:28327542
[Au] Autor:Ayaaba E; Li Y; Yuan J; Ni C
[Ad] Endereço:Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing 210000, China. lizerta1@yahoo.com.
[Ti] Título:Occupational Respiratory Diseases of Miners from Two Gold Mines in Ghana.
[So] Source:Int J Environ Res Public Health;14(3), 2017 Mar 22.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:n/a.
[Mh] Termos MeSH primário: Poeira/análise
Enfisema/epidemiologia
Ouro
Pneumopatias Obstrutivas/epidemiologia
Mineradores
Mineração
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos Transversais
Enfisema/induzido quimicamente
Gana/epidemiologia
Seres Humanos
Pneumopatias Obstrutivas/induzido quimicamente
Masculino
Meia-Idade
Doenças Profissionais/induzido quimicamente
Doenças Profissionais/epidemiologia
Exposição Ocupacional/prevenção & controle
Exposição Ocupacional/estatística & dados numéricos
Equipamento de Proteção Individual/utilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dust); 7440-57-5 (Gold)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE



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