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[PMID]:28464852
[Au] Autor:Al-Haidary AS; Alotaibi W; Alhaider SA; Al-Saleh S
[Ad] Endereço:Department of Pediatrics, King Fahad Medical City, P.O. Box 59046, Riyadh, 11525, Saudi Arabia. adelsanhan@yahoo.com.
[Ti] Título:A newly identified novel variant in the CSF2RA gene in a child with pulmonary alveolar proteinosis: a case report.
[So] Source:J Med Case Rep;11(1):122, 2017 May 02.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The congenital form of pulmonary alveolar proteinosis due to colony stimulating factor 2 receptor alpha gene mutations is a rare disease with only a few cases reported worldwide. In this study we report a new case of pulmonary alveolar proteinosis with a novel variant in colony stimulating factor 2 receptor alpha gene. CASE PRESENTATION: A 5-year-old Saudi boy presented with a history of progressive dyspnea over 6 months; he was diagnosed as having pulmonary alveolar proteinosis. A molecular study revealed a novel variation in colony stimulating factor 2 receptor alpha gene. His clinical condition showed significant improvement after whole lung lavage. CONCLUSIONS: This case has the typical presentation of congenital pulmonary alveolar proteinosis due to colony stimulating factor 2 receptor alpha defect with a novel variant in this gene likely to be pathogenic.
[Mh] Termos MeSH primário: Lavagem Broncoalveolar
Dispneia/fisiopatologia
Fator Estimulador de Colônias de Granulócitos e Macrófagos/genética
Mutação
Proteinose Alveolar Pulmonar/congênito
Receptores de Fator Estimulador das Colônias de Granulócitos e Macrófagos/genética
[Mh] Termos MeSH secundário: Pré-Escolar
Progressão da Doença
Dispneia/etiologia
Dispneia/terapia
Marcadores Genéticos
Fator Estimulador de Colônias de Granulócitos e Macrófagos/fisiologia
Seres Humanos
Masculino
Linhagem
Proteinose Alveolar Pulmonar/genética
Proteinose Alveolar Pulmonar/fisiopatologia
Proteinose Alveolar Pulmonar/terapia
Irmãos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CSF2RA protein, human); 0 (Genetic Markers); 0 (Receptors, Granulocyte-Macrophage Colony-Stimulating Factor); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1285-4


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[PMID]:29095306
[Au] Autor:Liu Y; Chen LL; Qiu YY; Xiao YL; Cai HR
[Ad] Endereço:Department of Respiratory, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
[Ti] Título:Clinical features of secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome: Two case reports.
[So] Source:Medicine (Baltimore);96(44):e8481, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by the abnormal accumulation of alveolar surfactant protein in alveolar spaces. Secondary PAP can result from myelodysplastic syndrome (MDS). PATIENT CONCERNS: But most reports described a single case; here we reported 2 cases of PAP secondary to MDS. One case developed secondary PAP at the same time as MDS, and the other developed during the course of MDS. DIAGNOSES: The diagnosis of PAP was made by bronchoalveolar lavage and based on the identification of periodic acid-Schiff-positive proteinaceous material. Chest high resolution CT (HRCT) scans showed variable distribution of ground glass opacities, but crazy-paving appearance was not seen in our 2 cases. INTERVENTIONS: Because the patients' general conditions were poor, whole lung lavage was not used in the 2 cases. OUTCOMES: And the 2 cases' prognoses were poor. LESSONS: In conclusion, pulmonary physicians should suspect the possibility of secondary PAP when they encounter unexplained pulmonary infiltrates with some hematologic or infectious disease that shows diffuse bilateral GGO on an HRCT scan.
[Mh] Termos MeSH primário: Síndromes Mielodisplásicas/complicações
Proteinose Alveolar Pulmonar/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Lavagem Broncoalveolar
Feminino
Seres Humanos
Masculino
Prognóstico
Proteinose Alveolar Pulmonar/diagnóstico
Proteinose Alveolar Pulmonar/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171103
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008481


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[PMID]:28771412
[Au] Autor:Griese M
[Ad] Endereço:Department of Pediatric Pneumology, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich and the German Center for Lung Research, Munich, Germany matthias.griese@med.uni-muenchen.de.
[Ti] Título:Pulmonary Alveolar Proteinosis: A Comprehensive Clinical Perspective.
[So] Source:Pediatrics;140(2), 2017 Aug.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pulmonary alveolar proteinosis is a broad group of rare diseases that are defined by the occupation of a lung's gas-exchange area by pulmonary surfactants that are not properly removed. The clinical and radiologic phenotypes among them are very similar. The age of manifestation plays a central role in the differential diagnosis of the almost 100 conditions and provides an efficient path to the correct diagnosis. The diagnostic approach is tailored to identify genetic or autoimmune causes, exposure to environmental agents, and associations with numerous other diseases. Whole-lung lavages are the cornerstone of treatment, and children in particular depend on the expertise to perform such therapeutic lavages. Other treatment options and long-term survival are related to the condition causing the proteinosis.
[Mh] Termos MeSH primário: Proteinose Alveolar Pulmonar/diagnóstico
[Mh] Termos MeSH secundário: Biópsia
Lavagem Broncoalveolar/métodos
Broncoscopia
Criança
Diagnóstico Diferencial
Seres Humanos
Aumento da Imagem
Pulmão/patologia
Proteinose Alveolar Pulmonar/patologia
Proteinose Alveolar Pulmonar/fisiopatologia
Proteinose Alveolar Pulmonar/terapia
Troca Gasosa Pulmonar/fisiologia
Surfactantes Pulmonares/metabolismo
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Pulmonary Surfactants)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


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[PMID]:28581337
[Au] Autor:Barnett RC; Lin X; Barravecchia M; Norman RA; de Mesy Bentley KL; Fazal F; Young JL; Dean DA
[Ad] Endereço:1 Division of Neonatology, University of Rochester, Rochester, New York, NY 14642, USA.
[Ti] Título:Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency.
[So] Source:Exp Biol Med (Maywood);242(13):1345-1354, 2017 Jul.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Surfactant Protein B Deficiency is a rare but lethal monogenetic, congenital lung disease of the neonate that is unresponsive to any treatment except lung transplantation. Based on the potential that gene therapy offers to treat such intractable diseases, our objective was to test whether an electroporation-based gene delivery approach could restore surfactant protein B expression and improve survival in a compound knockout mouse model of surfactant protein B deficiency. Surfactant protein B expression can be shut off in these mice upon withdrawl of doxycycline, resulting in decreased levels of surfactant protein B within four days and death due to lung dysfunction within four to seven days. Control or one of several different human surfactant protein B-expressing plasmids was delivered to the lung by aspiration and electroporation at the time of doxycycline removal or four days later. Plasmids expressing human surfactant protein B from either the UbC or CMV promoter expressed surfactant protein B in these transgenic mice at times when endogenous surfactant protein B expression was silenced. Mean survival was increased 2- to 5-fold following treatment with the UbC or CMV promoter-driven plasmids, respectively. Histology of all surfactant protein B treated groups exhibited fewer neutrophils and less alveolar wall thickening compared to the control groups, and electron microscopy revealed that gene transfer of surfactant protein B resulted in lamellar bodies that were similar in the presence of electron-dense, concentric material to those in surfactant protein B-expressing mice. Taken together, our results show that electroporation-mediated gene delivery of surfactant protein B-expressing plasmids improves survival, lung function, and lung histology in a mouse model of surfactant protein B deficiency and suggest that this may be a useful approach for the treatment of this otherwise deadly disease. Impact statement Surfactant protein B (SP-B) deficiency is a rare but lethal genetic disease of neonates that results in severe respiratory distress with no available treatments other than lung transplantation. The present study describes a novel treatment for this disease by transferring the SP-B gene to the lungs using electric fields in a mouse model. The procedure is safe and results in enough expression of exogenous SP-B to improve lung histology, lamellar body structure, and survival. If extended to humans, this approach could be used to bridge the time between diagnosis and lung transplantation and could greatly increase the likelihood of affected neonates surviving to transplantation and beyond.
[Mh] Termos MeSH primário: Eletroporação/métodos
Terapia Genética/métodos
Proteinose Alveolar Pulmonar/congênito
Proteína B Associada a Surfactante Pulmonar/deficiência
Proteína B Associada a Surfactante Pulmonar/genética
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Expressão Gênica
Inativação Gênica
Seres Humanos
Camundongos
Camundongos Transgênicos
Plasmídeos
Proteinose Alveolar Pulmonar/terapia
Análise de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pulmonary Surfactant-Associated Protein B)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217713000


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[PMID]:28500076
[Au] Autor:Eddy WE; Gong KQ; Bell B; Parks WC; Ziegler SF; Manicone AM
[Ad] Endereço:Center for Lung Biology, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98109.
[Ti] Título:Stat5 Is Required for CD103 Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.
[So] Source:J Immunol;198(12):4813-4822, 2017 Jun 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We tested the role of Stat5 in dendritic cell and alveolar macrophage (AM) homeostasis in the lung using CD11c-cre mediated deletion (Cre 5 ). We show that Stat5 is required for CD103 dendritic cell and AM development. We found that fetal monocyte maturation into AMs was impaired in Cre 5 mice, and we also confirmed impaired AM development of progenitor cells using mixed chimera experiments. In the absence of Stat5 signaling in AMs, mice developed alveolar proteinosis with altered lipid homeostasis. In addition, loss of Stat5 in CD11c cells was associated with exaggerated LPS-induced inflammatory responses and vascular leak. In Cre 5 mice, there was loss of immune-dampening effects on epithelial cells, a key source of CCL2 that serves to recruit monocytes and macrophages. These findings demonstrate the critical importance of Stat5 signaling in maintaining lung homeostasis, and underscore the importance of resident macrophages in moderating tissue damage and excess inflammation.
[Mh] Termos MeSH primário: Antígenos CD/imunologia
Células Dendríticas/fisiologia
Cadeias alfa de Integrinas/imunologia
Lesão Pulmonar/imunologia
Macrófagos Alveolares/fisiologia
Fator de Transcrição STAT5/metabolismo
[Mh] Termos MeSH secundário: Animais
Antígenos CD/genética
Líquido da Lavagem Broncoalveolar/citologia
Líquido da Lavagem Broncoalveolar/imunologia
Células Dendríticas/imunologia
Células Epiteliais/imunologia
Inflamação/imunologia
Cadeias alfa de Integrinas/genética
Macrófagos Alveolares/imunologia
Camundongos
Monócitos/imunologia
Proteinose Alveolar Pulmonar/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, CD); 0 (Integrin alpha Chains); 0 (STAT5 Transcription Factor); 0 (alpha E integrins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601777


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[PMID]:28489415
[Au] Autor:Hunt AN; Malur A; Monfort T; Lagoudakis P; Mahajan S; Postle AD; Thomassen MJ
[Ad] Endereço:1 Clinical and Experimental Sciences, Faculty of Medicine.
[Ti] Título:Hepatic Steatosis Accompanies Pulmonary Alveolar Proteinosis.
[So] Source:Am J Respir Cell Mol Biol;57(4):448-458, 2017 Oct.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maintenance of tissue-specific organ lipid compositions characterizes mammalian lipid homeostasis. The lungs and liver synthesize mixed phosphatidylcholine (PC) molecular species that are subsequently tailored for function. The lungs progressively enrich disaturated PC directed to lamellar body surfactant stores before secretion. The liver accumulates polyunsaturated PC directed to very-low-density lipoprotein assembly and secretion, or to triglyceride stores. In each tissue, selective PC species enrichment mechanisms lie at the heart of effective homeostasis. We tested for potential coordination between these spatially separated but possibly complementary phenomena under a major derangement of lung PC metabolism, pulmonary alveolar proteinosis (PAP), which overwhelms homeostasis and leads to excessive surfactant accumulation. Using static and dynamic lipidomics techniques, we compared (1) tissue PC compositions and contents, and (2) in lungs, the absolute rates of synthesis in both control mice and the granulocyte-macrophage colony-stimulating factor knockout model of PAP. Significant disaturated PC accumulation in bronchoalveolar lavage fluid, alveolar macrophage, and lavaged lung tissue occurred alongside increased PC synthesis, consistent with reported defects in alveolar macrophage surfactant turnover. However, microscopy using oil red O staining, coherent anti-Stokes Raman scattering, second harmonic generation, and transmission electron microscopy also revealed neutral-lipid droplet accumulations in alveolar lipofibroblasts of granular macrophage colony-stimulating factor knockout animals, suggesting that lipid homeostasis deficits extend beyond alveolar macrophages. PAP plasma PC composition was significantly polyunsaturated fatty acid enriched, but the content was unchanged and hepatic polyunsaturated fatty acid-enriched PC content increased by 50% with an accompanying micro/macrovesicular steatosis and a fibrotic damage pattern consistent with nonalcoholic fatty liver disease. These data suggest a hepatopulmonary axis of PC metabolism coordination, with wider implications for understanding and managing lipid pathologies in which compromise of one organ has unexpected consequences for another.
[Mh] Termos MeSH primário: Fígado Gorduroso/metabolismo
Fígado/metabolismo
Macrófagos Alveolares/metabolismo
Fosfatidilcolinas/metabolismo
Proteinose Alveolar Pulmonar/metabolismo
Alvéolos Pulmonares/metabolismo
[Mh] Termos MeSH secundário: Animais
Fígado Gorduroso/complicações
Fígado Gorduroso/genética
Feminino
Masculino
Camundongos
Camundongos Knockout
Especificidade de Órgãos/genética
Fosfatidilcolinas/genética
Proteinose Alveolar Pulmonar/etiologia
Proteinose Alveolar Pulmonar/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphatidylcholines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170511
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2016-0242OC


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[PMID]:28379131
[Au] Autor:Ernst G; Salvado A; Grynblat P; Tabaj G; Garcia O; Cambursano VH; Young P
[Ad] Endereço:Hospital Británico de Buenos Aires, Servicio de Neumonología CABA.
[Ti] Título:[Pulmonary alveolar proteinosis: role of GM-CSF Antibodies].
[Ti] Título:Proteinosis alveolar pulmonar: rol de los anticuerpo ANT-GM-CSF..
[So] Source:Rev Fac Cien Med Univ Nac Cordoba;74(1):46-50, 2017.
[Is] ISSN:1853-0605
[Cp] País de publicação:Argentina
[La] Idioma:spa
[Ab] Resumo:Pulmonary alveolar proteinosis is a rare illness characterized by alterations in the normal depuration of surfactants from the alveolar space in a process dependent of the granulocyte-monocyte colony stimulating factor (GM-CSF). The most of the patients develop antibodies that neutralize this factor, avoiding the normal homeostasis of surfactants. Therapeutic options include the total lung washes and administration of GM-CSF when the washes fail. Despite the contribution related with the knowledge about of the nature of the disease, the measurement of serum antibodies anti-GM-CSF is not a routine technique. We present a systematic review of this challenging disease.
[Mh] Termos MeSH primário: Autoanticorpos/imunologia
Fator Estimulador de Colônias de Granulócitos e Macrófagos/imunologia
Proteinose Alveolar Pulmonar/imunologia
[Mh] Termos MeSH secundário: Seres Humanos
Proteinose Alveolar Pulmonar/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Autoantibodies); 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170503
[Lr] Data última revisão:
170503
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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[PMID]:28301535
[Au] Autor:Sui X; Du Q; Xu KF; Tian X; Song L; Wang X; Xu X; Wang Z; Wang Y; Gu J; Song W; Jin Z
[Ad] Endereço:Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
[Ti] Título:Quantitative assessment of Pulmonary Alveolar Proteinosis (PAP) with ultra-dose CT and correlation with Pulmonary Function Tests (PFTs).
[So] Source:PLoS One;12(3):e0172958, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of this study was to investigate whether ultra-low-dose chest computed tomography (CT) can be used for visual assessment of CT features in patients with pulmonary alveolar proteinosis (PAP) and to evaluate the relationship between the quantitative analysis of the ultra-low-dose CT scans and the pulmonary function tests (PFTs). METHODS: Thirty-eight patients (mean [SD] age, 44.47 [12.28] years; 29 males, 9 females) with PAP were enrolled and subjected to two scans each with low-dose CT (reference parameters: 120 kV and 50 mAs) and ultra-low-dose CT (reference parameters, 80 kV, 25 mAs). Images were reconstructed via filtered back projection (FBP) for low-dose CT and iterative reconstruction (IR) for ultra-low-dose CT. All patients underwent PFT. The Visual analysis for ground glass opacity (GGO) is performed. The quantitative CT and PFT results were analyzed by canonical correlations. RESULTS: The mean body mass index (BMI) was 25.37±3.26 kg/m2. The effective radiation doses were 2.30±0.46 and 0.24±0.05 mSv for low-dose and ultra-low-dose CT, respectively. The size-specific dose estimates were 5.81±0.81 and 0.62±0.09 mSv for low-dose and ultra-low-dose CT. GGOs and interlobular septal thickening were observed bilaterally in all patients. The average visual GGO score was lower in the upper field (2.67±1.24) but higher in the middle and lower fields (3.08±1.32 and 3.08±0.97, respectively). The average score for the whole lung was 2.94±1.19. There is a significant correlation between PFTs and quantitative of ultra-low-dose CT (canonical loading = 0.78). CONCLUSIONS: Ultra-low-dose CT has the potential to quantify the lung parenchyma changes of PAP. This technique could provide a sensitive and objective assessment of PAP and has good relation with PFTs. In addition, the radiation dose of ultra-low-dose CT was very low.
[Mh] Termos MeSH primário: Proteinose Alveolar Pulmonar/diagnóstico por imagem
Testes de Função Respiratória
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Adulto
Relação Dose-Resposta à Radiação
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Proteinose Alveolar Pulmonar/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172958


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[PMID]:28270188
[Au] Autor:Galhenage J; Weerasinghe B; Dilesha W; Constantine R; Gunasena B
[Ad] Endereço:Department of Respiratory Medicine, National Hospital for Respiratory Diseases, Welisara, Sri Lanka. janithgalhenage@yahoo.co.uk.
[Ti] Título:Pulmonary alveolar proteinosis and first successful whole lung lavage in Sri Lanka: a case report.
[So] Source:J Med Case Rep;11(1):62, 2017 Mar 08.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pulmonary alveolar proteinosis is a rare disease characterized by accumulation of lipoproteinaceous material within alveoli. There are three clinically distinct forms: congenital, acquired and secondary. Whole lung lavage is currently the gold standard therapy for severe cases of pulmonary alveolar proteinosis. In Sri Lanka this is the first reported successful whole lung lavage for a patient with pulmonary alveolar proteinosis. CASE PRESENTATION: We describe the case of a 15-year-old Sri Lankan girl who presented with symptoms of progressive shortness of breath and dry cough for 6 months' duration. She had a history of exposure to silica in her household environment. High-resolution computed tomography revealed crazy paving appearance in both lungs suggestive of pulmonary alveolar proteinosis. An open lung biopsy revealed intra-alveolar granular amphophilic material which was strongly periodic acid-Schiff positive and diastase resistant, which is consistent with pulmonary alveolar proteinosis. She was followed up for 2 years with periodical segmental bronchoalveolar lavages which showed minimal improvement in her symptoms as well as in exercise desaturation. Due to severe dyspnea and hypoxemia on exertion, she underwent whole lung lavage. It resulted in a marked improvement in her symptoms, exercise desaturation, and chest X-ray results. CONCLUSION: Whole lung lavage was successfully performed for the first time in Sri Lanka for a patient with pulmonary alveolar proteinosis.
[Mh] Termos MeSH primário: Lavagem Broncoalveolar
Dispneia/etiologia
Pulmão/patologia
Proteinose Alveolar Pulmonar/diagnóstico
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Adolescente
Lavagem Broncoalveolar/métodos
Tosse/etiologia
Feminino
Seguimentos
Seres Humanos
Hipóxia/etiologia
Pulmão/diagnóstico por imagem
Proteinose Alveolar Pulmonar/patologia
Sri Lanka
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1218-2


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[PMID]:28212835
[Au] Autor:Raju S; Ghosh S; Mehta AC
[Ad] Endereço:Respiratory Institute, Cleveland Clinic, Cleveland, OH.
[Ti] Título:Chest CT Signs in Pulmonary Disease: A Pictorial Review.
[So] Source:Chest;151(6):1356-1374, 2017 Jun.
[Is] ISSN:1931-3543
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CT scanning of the chest is one of the most important imaging modalities available to a pulmonologist. The advent of high-resolution CT scanning of the chest has led to its increasing use. Although chest radiographs are still useful as an initial test, their utility is limited in the diagnosis of lung diseases that depend on higher resolution images such as interstitial lung diseases and pulmonary vascular diseases. Several metaphoric chest CT scan signs have been described linking abnormal imaging patterns to lung diseases. Some of these are specific to a disease, whereas others help narrow the differential diagnosis. Recognizing these imaging patterns and CT scan signs are thus vitally important. In the present article, we describe a comprehensive list of the commonly encountered metaphoric chest CT scan signs and their clinical relevance.
[Mh] Termos MeSH primário: Pneumopatias/diagnóstico por imagem
Pulmão/diagnóstico por imagem
Doenças Pleurais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico por imagem
Alveolite Alérgica Extrínseca/diagnóstico por imagem
Calcinose/diagnóstico por imagem
Carcinoma de Células Escamosas/diagnóstico por imagem
Angiografia por Tomografia Computadorizada
Pneumonia em Organização Criptogênica/diagnóstico por imagem
Fibrose Cística/diagnóstico por imagem
Empiema Pleural/diagnóstico por imagem
Corpos Estranhos/diagnóstico por imagem
Doenças Genéticas Inatas/diagnóstico por imagem
Hemorragia/diagnóstico por imagem
Seres Humanos
Aspergilose Pulmonar Invasiva/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pulmonares/secundário
Linfoma/diagnóstico por imagem
Tomografia Computadorizada Multidetectores
Infecção por Mycobacterium avium-intracellulare/diagnóstico por imagem
Pneumonia por Pneumocystis/diagnóstico por imagem
Proteinose Alveolar Pulmonar/diagnóstico por imagem
Atelectasia Pulmonar/diagnóstico por imagem
Sarcoidose Pulmonar/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE



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