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[PMID]:29437642
[Au] Autor:Davies JM; Thien F; Hew M
[Ad] Endereço:Office of Research, Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia, and Metro North Hospital and Health Service, Brisbane, Queensland, Australia.
[Ti] Título:Thunderstorm asthma: controlling (deadly) grass pollen allergy.
[So] Source:BMJ;360:k432, 2018 02 06.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Asma
Rinite Alérgica Sazonal
[Mh] Termos MeSH secundário: Alérgenos
Seres Humanos
Poaceae/imunologia
Pólen/imunologia
[Pt] Tipo de publicação:LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Nm] Nome de substância:
0 (Allergens)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.k432


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[PMID]:27770477
[Au] Autor:Groh N; von Loetzen CS; Subbarayal B; Möbs C; Vogel L; Hoffmann A; Fötisch K; Koutsouridou A; Randow S; Völker E; Seutter von Loetzen A; Rösch P; Vieths S; Pfützner W; Bohle B; Schiller D
[Ad] Endereço:Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany.
[Ti] Título:IgE and allergen-specific immunotherapy-induced IgG recognize similar epitopes of Bet v 1, the major allergen of birch pollen.
[So] Source:Clin Exp Allergy;47(5):693-703, 2017 May.
[Is] ISSN:1365-2222
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allergen-specific immunotherapy (AIT) with birch pollen generates Bet v 1-specific immunoglobulin (Ig)G which blocks IgE-mediated hypersensitivity mechanisms. Whether IgG specific for Bet v 1a competes with IgE for identical epitopes or whether novel epitope specificities of IgG antibodies are developed is under debate. OBJECTIVE: We sought to analyze the epitope specificities of IgE and IgG antibodies from sera of patients who received AIT. METHODS: 15 sera of patients (13/15 received AIT) with Bet v 1a-specific IgE and IgG were analyzed. The structural arrangements of recombinant (r)Bet v 1a and rBet v 1a , modified in five potential epitopes, were analyzed by circular dichroism and nuclear magnetic resonance spectroscopy. IgE binding to Bet v 1 was assessed by ELISA and mediator release assays. Competitive binding of monoclonal antibodies specific for Bet v 1a and serum IgE/IgG to rBet v 1a and serum antibody binding to a non-allergenic Bet v 1-type model protein presenting an individual epitope for IgE was analyzed in ELISA and western blot. RESULTS: rBet v 1a had a Bet v 1a - similar secondary and tertiary structure. Monomeric dispersion of rBet v 1a was concentration and buffer-dependent. Up to 1500-fold increase in the EC for IgE-mediated mediator release induced by rBet v 1a was determined. The reduction of IgE and IgG binding to rBet v 1a was comparable in 67% (10/15) of sera. Bet v 1a-specific monoclonal antibodies inhibited binding of serum IgE and IgG to 66.1% and 64.9%, respectively. Serum IgE and IgG bound specifically to an individual epitope presented by our model protein in 33% (5/15) of sera. CONCLUSION AND CLINICAL RELEVANCE: Patients receiving AIT develop Bet v 1a-specific IgG which competes with IgE for partly identical or largely overlapping epitopes. The similarities of epitopes for IgE and IgG might stimulate the development of epitope-specific diagnostics and therapeutics.
[Mh] Termos MeSH primário: Antígenos de Plantas/imunologia
Dessensibilização Imunológica
Epitopos/imunologia
Imunoglobulina E
Imunoglobulina G
Rinite Alérgica Sazonal
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Imunoglobulina E/sangue
Imunoglobulina E/imunologia
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
Masculino
Camundongos
Rinite Alérgica Sazonal/sangue
Rinite Alérgica Sazonal/imunologia
Rinite Alérgica Sazonal/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Plant); 0 (Epitopes); 0 (Immunoglobulin G); 126161-14-6 (Bet v 1 allergen, Betula); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1111/cea.12835


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[PMID]:29181536
[Au] Autor:Wallace DV; Dykewicz MS; Oppenheimer J; Portnoy JM; Lang DM
[Ad] Endereço:From Nova Southeastern University, Fort Lauderdale, Florida; Saint Louis University School of Medicine, St. Louis, Missouri; Rutgers New Jersey Medical School, Newark, New Jersey; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; and Cleveland Clinic Foundation, Cleveland
[Ti] Título:Pharmacologic Treatment of Seasonal Allergic Rhinitis: Synopsis of Guidance From the 2017 Joint Task Force on Practice Parameters.
[So] Source:Ann Intern Med;167(12):876-881, 2017 Dec 19.
[Is] ISSN:1539-3704
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Description: The Joint Task Force on Practice Parameters, which comprises representatives of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), formed a workgroup to review evidence and provide guidance to health care providers on the initial pharmacologic treatment of seasonal allergic rhinitis in patients aged 12 years or older. Methods: To update a prior systematic review, the workgroup searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from 18 July 2012 to 29 July 2016 to identify studies that addressed efficacy and adverse effects of single or combination pharmacotherapy for seasonal allergic rhinitis. In conjunction with the Joint Task Force, the workgroup reviewed the evidence and developed recommendations about initial treatment approaches by using the Grading of Recommendations Assessment, Development and Evaluation approach. Members of the AAAAI, the ACAAI, and the general public provided feedback on the draft document, which the Joint Task Force reviewed before finalizing the guideline. Recommendation 1: For initial treatment of seasonal allergic rhinitis in persons aged 12 years or older, routinely prescribe monotherapy with an intranasal corticosteroid rather than an intranasal corticosteroid in combination with an oral antihistamine. (Strong recommendation). Recommendation 2: For initial treatment of seasonal allergic rhinitis in persons aged 15 years or older, recommend an intranasal corticosteroid over a leukotriene receptor antagonist. (Strong recommendation). Recommendation 3: For treatment of moderate to severe seasonal allergic rhinitis in persons aged 12 years or older, the clinician may recommend the combination of an intranasal corticosteroid and an intranasal antihistamine for initial treatment. (Weak recommendation).
[Mh] Termos MeSH primário: Rinite Alérgica Sazonal/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Intranasal
Administração Oral
Adolescente
Corticosteroides/administração & dosagem
Corticosteroides/uso terapêutico
Fatores Etários
Quimioterapia Combinada
Antagonistas dos Receptores Histamínicos/administração & dosagem
Antagonistas dos Receptores Histamínicos/uso terapêutico
Seres Humanos
Antagonistas de Leucotrienos/administração & dosagem
Antagonistas de Leucotrienos/uso terapêutico
Rinite Alérgica Sazonal/diagnóstico
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; PRACTICE GUIDELINE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Histamine Antagonists); 0 (Leukotriene Antagonists)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.7326/M17-2203


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[PMID]:28457642
[Au] Autor:Wasan A; Nanda A
[Ad] Endereço:Allergy and Asthma Center, McLean, Virginia.
[Ti] Título:Systemic reaction to timothy grass pollen sublingual immunotherapy.
[So] Source:Ann Allergy Asthma Immunol;118(6):732-733, 2017 Jun.
[Is] ISSN:1534-4436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anafilaxia/induzido quimicamente
Pólen/efeitos adversos
Rinite Alérgica Sazonal/prevenção & controle
Imunoterapia Sublingual/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Phleum
Extratos Vegetais/efeitos adversos
Extratos Vegetais/imunologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28455783
[Au] Autor:Shah-Hosseini K; Krudewig EM; Hadler M; Karagiannis E; Mösges R
[Ad] Endereço:Institute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, Cologne, Germany.
[Ti] Título:Management of Grass Pollen Allergy with 5-Grass Pollen Tablet: Results of a 2-Year Real-Life Study.
[So] Source:Adv Ther;34(6):1382-1397, 2017 Jun.
[Is] ISSN:1865-8652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Allergen immunotherapy is the only treatment option for allergic rhinitis with disease-altering potential. It was the objective of this study to assess the effectiveness and tolerability of a 5-grass pollen tablet in a large population of non-selected grass pollen allergic patients, i.e. patients with different clinical profiles in daily clinical practice. METHODS: In a 2-year, prospective, open-label, multicenter, non-controlled, observational study patients were included from 327 centers across Germany. Rhinoconjunctivitis symptoms, symptomatic medication intake and adverse events were recorded. RESULTS: A total of 1482 patients aged 4-75 years were included. During the 2-year period of 5-grass pollen tablet therapy, mean rhinoconjunctivitis score decreased significantly in the overall study population by 65.5% (P < 0.001). The percentage of patients taking symptomatic medication decreased from 83.8% to 42.7%. Mean 2-year improvements in rhinoconjunctivitis scores and decreases in the percentage of patients taking symptomatic medication were broadly similar in adults, adolescents and children, in patients with polyallergy versus monoallergy, and in patients with/without asthma. Among polyallergic patients, concomitant application of another specific immunotherapy did not impair treatment outcomes. Adverse drug reactions, predominantly affecting the local application area, occurred in 15.4% of the overall patient population (n = 229). No cases of anaphylaxis or epinephrine use were documented. CONCLUSION: This study indicates that sublingual immunotherapy with the 5-grass pollen tablet is well tolerated and provides sustained effectiveness over 2 years in patients with different clinical profiles, producing a significant decrease in allergic symptoms and a reduction in the use of symptomatic medication. FUNDING: Stallergenes GmbH.
[Mh] Termos MeSH primário: Poaceae
Pólen
Rinite Alérgica Sazonal/tratamento farmacológico
Imunoterapia Sublingual/métodos
[Mh] Termos MeSH secundário: Administração Sublingual
Adolescente
Adulto
Idoso
Criança
Pré-Escolar
Conjuntivite Alérgica/tratamento farmacológico
Feminino
Alemanha
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Rinite Alérgica/tratamento farmacológico
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:T
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s12325-017-0535-6


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[PMID]:28829861
[Ti] Título:Vaccine Treatment Again.
[So] Source:JAMA;318(8):758, 2017 08 22.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vacinas Bacterianas/história
[Mh] Termos MeSH secundário: Publicidade como Assunto/história
Vacinas Bacterianas/uso terapêutico
História do Século XX
Seres Humanos
Rinite Alérgica Sazonal/história
Rinite Alérgica Sazonal/terapia
[Pt] Tipo de publicação:CLASSICAL ARTICLE; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.9460


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[PMID]:28818439
[Au] Autor:Wan J; Mitra N; Hoffstad OJ; Gelfand JM; Yan AC; Margolis DJ
[Ad] Endereço:Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address: Joy.Wan@uphs.upenn.edu.
[Ti] Título:Variations in risk of asthma and seasonal allergies between early- and late-onset pediatric atopic dermatitis: A cohort study.
[So] Source:J Am Acad Dermatol;77(4):634-640, 2017 Oct.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Atopic dermatitis is associated with other allergic conditions, but variations in this "atopic march" are poorly understood. OBJECTIVE: To determine the impact of the age of atopic dermatitis onset on the risk for asthma and seasonal allergies. METHODS: A cohort study was performed using the Pediatric Eczema Elective Registry, which is an observational cohort of subjects with pediatric onset atopic dermatitis. RESULTS: In total, 3966 children were included, and 73% reported atopic dermatitis onset before age 2 years. At baseline, subjects with atopic dermatitis onset at ages 3 to 7 or 8 to 17 years had significantly lower rates of seasonal allergies and asthma than those with onset before age 2. During follow-up, the adjusted relative risks for incident seasonal allergies were 0.82 (95% confidence interval, 0.72-0.91) and 0.64 (95% CI confidence interval, 0.47-0.83) in the 3- to 7- and 8- to 17-years-old at onset groups compared with the age 2 years or younger at onset group. The adjusted risk for incident asthma was not significantly different between the older onset groups and the earliest onset group. LIMITATIONS: Misclassification bias may arise from using self-reported onset age data. CONCLUSIONS: The timing of atopic dermatitis onset may explain part of the variation in the atopic march. These findings may improve future risk stratification of patients for treatment.
[Mh] Termos MeSH primário: Asma/epidemiologia
Dermatite Atópica/diagnóstico
Rinite Alérgica Sazonal/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Idade de Início
Criança
Pré-Escolar
Estudos de Coortes
Feminino
Seres Humanos
Incidência
Lactente
Masculino
Prevalência
Sistema de Registros
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE


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[PMID]:28768942
[Au] Autor:Yamashiro K; Ogata F; Kawasaki N
[Ad] Endereço:Department of Public Health, Faculty of Pharmacy, Kindai University.
[Ti] Título:Relationship between Hay Fever and Mineral Concentration in the Hair, Lifestyle or Aging.
[So] Source:Yakugaku Zasshi;137(8):1035-1040, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:It is important to ingest just proportions of minerals to prevent disease, but these minerals are also secreted into the hair. Meanwhile, the number of hay fever patients in Japan is increasing, causing an increase in national medical expenses. In this study, we investigated the relationship between hay fever and mineral concentrations in hair to obtain findings on the risk of developing pollen allergies. A questionnaire survey was conducted for 275 men and 977 women on their lifestyle habits and ten kinds of mineral concentrations present in their hair were measured with subsequent analysis using nominal logistic regression analysis. The results indicated that half the patients in each age group had hay fever, with no significant difference between hay fever and aging, exercise habits, sleep and dietary rhythms. On the other hand, there was a significant difference between hay fever and mineral concentrations in the hair, and in men with hay fever, iron (odds ratio: 0.55, p<0.05) was low, while in women calcium (odds ratio: 0.67, p<0.05), chromium (odds ratio: 0.46, p<0.001), cadmium (odds ratio: 0.68, p<0.01) were low and selenium (odds ratio: 1.78, p<0.01) was high. These results, suggest that measurements mineral concentrations in hair are indicators of hay fever risk.
[Mh] Termos MeSH primário: Envelhecimento
Cabelo/química
Estilo de Vida
Minerais/análise
Rinite Alérgica Sazonal/etiologia
Rinite Alérgica Sazonal/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Envelhecimento/metabolismo
Biomarcadores/análise
Cádmio/análise
Cálcio/análise
Cromo/análise
Feminino
Seres Humanos
Ferro/análise
Modelos Logísticos
Masculino
Meia-Idade
Rinite Alérgica Sazonal/diagnóstico
Risco
Selênio/análise
Inquéritos e Questionários
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Minerals); 00BH33GNGH (Cadmium); 0R0008Q3JB (Chromium); E1UOL152H7 (Iron); H6241UJ22B (Selenium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00078


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[PMID]:28731414
[Au] Autor:El-Qutob D; Bartolome B; Cuesta J; Mir A; Alberola A; Pastor-Vargas C
[Ad] Endereço:Unit of Allergy, University Hospital of La Plana, Vila-Real, Spain.
[Ti] Título:Identification of a Lipid Transfer Protein as a New Allergen From Morus alba Pollen.
[So] Source:J Investig Allergol Clin Immunol;27(4):263-265, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/imunologia
Antígenos de Plantas/imunologia
Proteínas de Transporte/imunologia
Morus/imunologia
Proteínas de Plantas/imunologia
Pólen/imunologia
Rinite Alérgica Sazonal/imunologia
[Mh] Termos MeSH secundário: Adulto
Eletroforese em Gel de Poliacrilamida
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Carrier Proteins); 0 (Plant Proteins); 0 (lipid transfer proteins, plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0162


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[PMID]:28731413
[Au] Autor:Di Cara G; Panfili E; Marseglia GL; Pacitto A; Salvatori C; Testa I; Fabiano C; Verrotti A; Latini A
[Ad] Endereço:Università degli Studi di Perugia, Dipartimento di Scienze Chirurgiche e Biomediche, Perugia, Italy.
[Ti] Título:Association Between Pollen Exposure and Nasal Cytokines in Grass Pollen-Allergic Children.
[So] Source:J Investig Allergol Clin Immunol;27(4):261-263, 2017.
[Is] ISSN:1018-9068
[Cp] País de publicação:Spain
[La] Idioma:eng
[Mh] Termos MeSH primário: Alérgenos/imunologia
Citocinas/imunologia
Exposição Ambiental
Proteína Catiônica de Eosinófilo/imunologia
Poaceae/imunologia
Pólen/imunologia
Rinite Alérgica Sazonal/imunologia
Triptases/imunologia
[Mh] Termos MeSH secundário: Criança
Eosinófilos/imunologia
Feminino
Seres Humanos
Masculino
Mastócitos/imunologia
Líquido da Lavagem Nasal/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Cytokines); EC 3.1.27.- (Eosinophil Cationic Protein); EC 3.1.27.- (RNASE3 protein, human); EC 3.4.21.59 (Tryptases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170722
[St] Status:MEDLINE
[do] DOI:10.18176/jiaci.0161



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